carboprost and Cardiovascular-Diseases

Within the last few years intra-amniotic (i.a.) instillation of prostaglandin F2 alpha (PGF2 alpha) has become the predominant method of second-trimester abortion in Denmark. The method is employed by nearly all the gynecological departments, where approximately 500 such procedures are carried out annually. Our own investigations have demonstrated that it is necessary to be somewhat restrictive in the administration of supplementary intravenous infusion of oxytocin. It is pointed out, illustrated by four case histories, that there is a potential risk of greater or smaller quantities of i.a. PGF2 alpha accidentally passing during the procedure to the circulation of the patient. This may result in circulatory collapse, among other things, possibly as a result of acute pulmonary hypertension. A number of safety measures are suggested to minimize this risk and to ensure effective treatment should such complications occur.

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Amnion; Anaphylaxis; Carboprost; Cardiovascular Diseases; Denmark; Dinoprost; Drug Evaluation; Female; Humans; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Prostaglandins F; Saline Solution, Hypertonic

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Amnion; Carboprost; Cardiovascular Diseases; Cervix Uteri; Dinoprost; Dinoprostone; Female; Humans; Injections; Injections, Intramuscular; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Prostaglandins; Prostaglandins E, Synthetic; Prostaglandins F; Suppositories; Uterus; Vagina