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carbonyl cyanide p-trifluoromethoxyphenylhydrazone and Hypoxia

carbonyl cyanide p-trifluoromethoxyphenylhydrazone has been researched along with Hypoxia in 19 studies

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.
carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"Thus anoxia has multiple effects on [Ca2+]i homeostasis in sensory neurons involving internal stores, mitochondrial buffering, and Ca2+ pumps."1.35Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons. ( Buckler, KJ; Henrich, M, 2008)
"Chemical anoxia induced by cyanide, rotenone or p-trifluoromethoxy-phenylhydrazone (FCCP) decreased pH(i) by >0."1.32Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances. ( Ballanyi, K; Raupach, T, 2004)
"Compared with anoxia, hypoxic tubules exhibited greater preservation of ATP and K+ contents during O2 deprivation and more fully recovered oxidative metabolism and transport function during reoxygenation."1.28Differential effects of respiratory inhibitors on glycolysis in proximal tubules. ( Dickman, KG; Mandel, LJ, 1990)
"At the end of anoxia, hyperglycemic cats exhibited significantly higher cortical lactate and glucose levels but similarly reduced high-energy phosphate concentrations compared to normoglycemic cats."1.27Hyperglycemia preserves brain mitochondrial respiration during anoxia. ( Myers, RE; Wagner, KR, 1986)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's3 (15.79)18.2507
2000's11 (57.89)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, J1
Hogan, JO1
Kim, D1
Forgan, LG1
Forster, ME1
Kang, TM1
Park, MK1
Uhm, DY1
Tauskela, JS1
Brunette, E1
Monette, R1
Comas, T1
Morley, P1
Wyatt, CN1
Buckler, KJ2
Raupach, T1
Ballanyi, K1
Feldkamp, T1
Kribben, A1
Weinberg, JM1
Deng, W1
Yue, Q1
Rosenberg, PA1
Volpe, JJ1
Jensen, FE1
Thomas, R1
Kim, MH1
Henrich, M1
Tripmacher, R1
Gaber, T1
Dziurla, R1
Häupl, T1
Erekul, K1
Grützkau, A1
Tschirschmann, M1
Scheffold, A1
Radbruch, A1
Burmester, GR1
Buttgereit, F1
Aw, TY1
Jones, DP1
Gleitz, J1
Beile, A1
Khan, S1
Wilffert, B1
Tegtmeier, F1
Du, G1
Mouithys-Mickalad, A1
Sluse, FE1
Zhu, Z1
Li, YL1
Li, DP1
He, RR1
Knopp, A1
Thierfelder, S1
Doepner, B1
Benndorf, K1
Dickman, KG1
Mandel, LJ1
Wagner, KR1
Myers, RE1
Kauppinen, RA1
Nicholls, DG1

Other Studies

19 other studies available for carbonyl cyanide p-trifluoromethoxyphenylhydrazone and Hypoxia

ArticleYear
Voltage- and receptor-mediated activation of a non-selective cation channel in rat carotid body glomus cells.
    Respiratory physiology & neurobiology, 2017, Volume: 237

    Topics: Action Potentials; Angiotensin II; Anilides; Animals; Animals, Newborn; Caffeine; Calcium; Calcium C

2017
Oxygen-dependence of metabolic rate in the muscles of craniates.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010, Volume: 180, Issue:5

    Topics: 2,4-Dinitrophenol; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Energy Metabolism; F

2010
Effects of hypoxia and mitochondrial inhibition on the capacitative calcium entry in rabbit pulmonary arterial smooth muscle cells.
    Life sciences, 2003, Feb-14, Volume: 72, Issue:13

    Topics: Animals; Calcium; Calcium Channel Blockers; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell

2003
Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling.
    American journal of physiology. Cell physiology, 2003, Volume: 285, Issue:4

    Topics: 2,4-Dinitrophenol; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Cal

2003
The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells.
    The Journal of physiology, 2004, Apr-01, Volume: 556, Issue:Pt 1

    Topics: Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carotid Body; Electron Transpo

2004
Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances.
    Brain research, 2004, Aug-13, Volume: 1017, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Carbonyl Cyanide p-Trifluoromethoxyphenyl

2004
Assessment of mitochondrial membrane potential in proximal tubules after hypoxia-reoxygenation.
    American journal of physiology. Renal physiology, 2005, Volume: 288, Issue:6

    Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Benzimidazoles; Carbocyanines; Carbonyl Cyanid

2005
Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function.
    Journal of neurochemistry, 2006, Volume: 98, Issue:1

    Topics: Animals; Animals, Newborn; Benzimidazoles; Brain; Calcium; Carbocyanines; Carbonyl Cyanide p-Trifluo

2006
Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers.
    Molecular and cellular biochemistry, 2007, Volume: 296, Issue:1-2

    Topics: Acetophenones; Basic Helix-Loop-Helix Transcription Factors; Benzopyrans; Carbonyl Cyanide p-Trifluo

2007
Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
    Journal of neurophysiology, 2008, Volume: 100, Issue:1

    Topics: Analysis of Variance; Animals; Caffeine; Calcium; Calcium Signaling; Capsaicin; Carbonyl Cyanide p-T

2008
Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production.
    European journal of immunology, 2008, Volume: 38, Issue:6

    Topics: Adenosine Triphosphate; Arthritis, Rheumatoid; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; C

2008
Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration.
    The Journal of biological chemistry, 1982, Aug-10, Volume: 257, Issue:15

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhyd

1982
Anaerobic glycolysis and postanoxic recovery of respiration of rat cortical synaptosomes are reduced by synaptosomal sodium load.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Anaerobiosis; Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cerebral Cortex;

1993
Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro.
    Free radical biology & medicine, 1998, Volume: 25, Issue:9

    Topics: Adenosine Diphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration

1998
Effect of anoxic preconditioning on ATP-sensitive potassium channels in guinea-pig ventricular myocytes.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 439, Issue:6

    Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Carbonyl Cyanide p-Trifluoromethox

2000
Mitochondria are the main ATP source for a cytosolic pool controlling the activity of ATP-sensitive K(+) channels in mouse cardiac myocytes.
    Cardiovascular research, 2001, Volume: 52, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cytosol; Egtazi

2001
Differential effects of respiratory inhibitors on glycolysis in proximal tubules.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 2

    Topics: Adenosine Triphosphate; Animals; Antimycin A; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Gl

1990
Hyperglycemia preserves brain mitochondrial respiration during anoxia.
    Journal of neurochemistry, 1986, Volume: 47, Issue:5

    Topics: Animals; Brain; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cats; Glutamates; Glutamic Acid;

1986
Failure to maintain glycolysis in anoxic nerve terminals.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Adenine Nucleotides; Animals; Calcimycin; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazon

1986