carbonyl cyanide p-trifluoromethoxyphenylhydrazone has been researched along with Disease Models, Animal in 11 studies
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.
carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study was designed to determine the optimal dosage and therapeutic window of opportunity for the potent mitochondrial uncoupler FCCP following moderate TBI." | 1.35 | The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP. ( Pandya, JD; Pauly, JR; Sullivan, PG, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Du, L | 1 |
| Mahdi, F | 1 |
| Jekabsons, MB | 1 |
| Nagle, DG | 1 |
| Zhou, YD | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Weng, X | 1 |
| Liu, H | 1 |
| Zhang, X | 1 |
| Sun, Q | 1 |
| Li, C | 1 |
| Gu, M | 1 |
| Xu, Y | 1 |
| Li, S | 1 |
| Du, J | 1 |
| Pandya, JD | 2 |
| Pauly, JR | 2 |
| Sullivan, PG | 2 |
| Zhou, J | 1 |
| Yi, J | 1 |
| Fu, R | 1 |
| Liu, E | 1 |
| Siddique, T | 1 |
| Ríos, E | 1 |
| Deng, HX | 1 |
| Flynn, JM | 1 |
| Choi, SW | 1 |
| Day, NU | 1 |
| Gerencser, AA | 1 |
| Hubbard, A | 1 |
| Melov, S | 1 |
| Schuh, RA | 1 |
| Jackson, KC | 1 |
| Khairallah, RJ | 1 |
| Ward, CW | 1 |
| Spangenburg, EE | 1 |
| Chee, FC | 1 |
| Mudher, A | 1 |
| Cuttle, MF | 1 |
| Newman, TA | 1 |
| MacKay, D | 1 |
| Lovestone, S | 1 |
| Shepherd, D | 1 |
| Rinaldi, GJ | 1 |
| Nukala, VN | 1 |
| Sebastian, AH | 1 |
| Day, KM | 1 |
| Korde, AS | 1 |
| Maragos, WF | 1 |
| Hall, ED | 1 |
| Olorunsogo, OO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism.[NCT00821132] | 13,521 participants (Actual) | Observational | 1991-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for carbonyl cyanide p-trifluoromethoxyphenylhydrazone and Disease Models, Animal
| Article | Year |
|---|---|
Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Coumarins; Disease Models, Animal; Dominica; Electron Tr | 2010 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
An α
Topics: Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; Carbonyl Cyanide p-Tri | 2020 |
The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP.
Topics: Animals; Brain Injuries; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Disease Models, Animal; | 2009 |
Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Calcium Signaling; Carbonyl Cyanide p-Trifluorometh | 2010 |
Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice.
Topics: 4-Aminopyridine; Animals; Biomimetics; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cerebral | 2011 |
Measuring mitochondrial respiration in intact single muscle fibers.
Topics: Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Cells, Cultured; Dise | 2012 |
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions.
Topics: Animals; Animals, Genetically Modified; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Res | 2005 |
Blood pressure fall and increased relaxation of aortic smooth muscle in diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Calcium; Calcium Signaling; Carbonyl Cya | 2005 |
Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents.
Topics: 2,4-Dinitrophenol; Animals; Brain; Brain Injuries; Calcium Signaling; Carbonyl Cyanide p-Trifluorome | 2007 |
Defective mitochondrial cation transport during dietary protein deficiency in rats.
Topics: Age Factors; Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cations; Cell Mem | 1992 |