carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Trypanosomiasis, African in 2 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with protozoans of the species Trypanosoma brucei gambiense and T." | 1.35 | The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. ( Lanteri, CA; Meshnick, SR; Tidwell, RR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lanteri, CA | 1 |
| Tidwell, RR | 1 |
| Meshnick, SR | 1 |
| Lomo, PO | 1 |
| Makawiti, DW | 1 |
| Konji, VN | 1 |
2 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Trypanosomiasis, African
| Article | Year |
|---|---|
The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
Topics: Animals; Benzamidines; Blood; Flow Cytometry; Fluorescent Dyes; Membrane Potentials; Mice; Mitochond | 2008 |
Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine.
Topics: Adenosine Diphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Glutamates; Glutamic Acid | 1993 |