carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Parkinson Disease in 24 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibition of complex I with the Parkinson's disease-inducing metabolite 1-methyl-4-phenylpyridinium (MPP+) similarly reduced the rate of recovery after carbachol." | 1.30 | Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. ( Davis, RE; Miller, SW; Parker, WD; Sheehan, JP; Swerdlow, RH; Tuttle, JB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 21 (87.50) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Osgerby, L | 1 |
| Lai, YC | 1 |
| Thornton, PJ | 1 |
| Amalfitano, J | 1 |
| Le Duff, CS | 1 |
| Jabeen, I | 1 |
| Kadri, H | 1 |
| Miccoli, A | 1 |
| Tucker, JHR | 1 |
| Muqit, MMK | 1 |
| Mehellou, Y | 1 |
| Ma, KY | 1 |
| Fokkens, MR | 1 |
| Reggiori, F | 1 |
| Mari, M | 1 |
| Verbeek, DS | 1 |
| La Cognata, V | 1 |
| Maugeri, G | 1 |
| D'Amico, AG | 1 |
| Saccone, S | 1 |
| Federico, C | 1 |
| Cavallaro, S | 1 |
| D'Agata, V | 1 |
| Xiao, B | 1 |
| Deng, X | 1 |
| Lim, GGY | 1 |
| Xie, S | 1 |
| Zhou, ZD | 1 |
| Lim, KL | 2 |
| Tan, EK | 1 |
| Back, MJ | 1 |
| Ha, HC | 1 |
| Fu, Z | 1 |
| Choi, JM | 1 |
| Piao, Y | 1 |
| Won, JH | 1 |
| Jang, JM | 1 |
| Shin, IC | 1 |
| Kim, DK | 1 |
| Bonello, F | 1 |
| Hassoun, SM | 1 |
| Mouton-Liger, F | 1 |
| Shin, YS | 1 |
| Muscat, A | 1 |
| Tesson, C | 1 |
| Lesage, S | 1 |
| Beart, PM | 1 |
| Brice, A | 1 |
| Krupp, J | 1 |
| Corvol, JC | 1 |
| Corti, O | 1 |
| Tai, HR | 1 |
| Jiang, CA | 1 |
| Burchell, VS | 1 |
| Nelson, DE | 1 |
| Sanchez-Martinez, A | 1 |
| Delgado-Camprubi, M | 1 |
| Ivatt, RM | 1 |
| Pogson, JH | 1 |
| Randle, SJ | 1 |
| Wray, S | 1 |
| Lewis, PA | 1 |
| Houlden, H | 1 |
| Abramov, AY | 1 |
| Hardy, J | 1 |
| Wood, NW | 1 |
| Whitworth, AJ | 1 |
| Laman, H | 1 |
| Plun-Favreau, H | 1 |
| Poliquin, PO | 1 |
| Chen, J | 1 |
| Cloutier, M | 1 |
| Trudeau, LÉ | 1 |
| Jolicoeur, M | 1 |
| Lee, S | 2 |
| Zhang, C | 1 |
| Liu, X | 2 |
| Norris, KL | 1 |
| Hao, R | 1 |
| Chen, LF | 1 |
| Lai, CH | 1 |
| Kapur, M | 1 |
| Shaughnessy, PJ | 1 |
| Chou, D | 1 |
| Yan, J | 1 |
| Taylor, JP | 1 |
| Engelender, S | 1 |
| West, AE | 1 |
| Yao, TP | 1 |
| Meissner, C | 1 |
| Lorenz, H | 1 |
| Hehn, B | 1 |
| Lemberg, MK | 1 |
| Koentjoro, B | 1 |
| Park, JS | 1 |
| Sue, CM | 1 |
| Vives-Bauza, C | 1 |
| Zhou, C | 1 |
| Huang, Y | 1 |
| Cui, M | 1 |
| de Vries, RL | 1 |
| Kim, J | 1 |
| May, J | 1 |
| Tocilescu, MA | 1 |
| Liu, W | 2 |
| Ko, HS | 1 |
| Magrané, J | 1 |
| Moore, DJ | 1 |
| Dawson, VL | 1 |
| Grailhe, R | 1 |
| Dawson, TM | 1 |
| Li, C | 1 |
| Tieu, K | 1 |
| Przedborski, S | 1 |
| Matsuda, N | 1 |
| Sato, S | 2 |
| Shiba, K | 1 |
| Okatsu, K | 1 |
| Saisho, K | 1 |
| Gautier, CA | 1 |
| Sou, YS | 1 |
| Saiki, S | 1 |
| Kawajiri, S | 1 |
| Sato, F | 1 |
| Kimura, M | 1 |
| Komatsu, M | 1 |
| Hattori, N | 3 |
| Tanaka, K | 1 |
| Yang, H | 1 |
| Zhou, X | 1 |
| Yang, L | 1 |
| Chen, Q | 1 |
| Zhao, D | 1 |
| Zuo, J | 1 |
| Hatano, T | 1 |
| Liu, S | 1 |
| Sawada, T | 1 |
| Yu, W | 1 |
| Silverio, G | 1 |
| Alapatt, P | 1 |
| Millan, I | 1 |
| Shen, A | 1 |
| Saxton, W | 1 |
| Kanao, T | 1 |
| Takahashi, R | 1 |
| Imai, Y | 1 |
| Lu, B | 1 |
| Kondapalli, C | 1 |
| Kazlauskaite, A | 1 |
| Zhang, N | 1 |
| Woodroof, HI | 1 |
| Campbell, DG | 1 |
| Gourlay, R | 1 |
| Burchell, L | 1 |
| Walden, H | 1 |
| Macartney, TJ | 1 |
| Deak, M | 1 |
| Knebel, A | 1 |
| Alessi, DR | 1 |
| Muqit, MM | 1 |
| Imaizumi, Y | 1 |
| Okada, Y | 1 |
| Akamatsu, W | 1 |
| Koike, M | 1 |
| Kuzumaki, N | 1 |
| Hayakawa, H | 1 |
| Nihira, T | 1 |
| Kobayashi, T | 1 |
| Ohyama, M | 1 |
| Takanashi, M | 1 |
| Funayama, M | 1 |
| Hirayama, A | 1 |
| Soga, T | 1 |
| Hishiki, T | 1 |
| Suematsu, M | 1 |
| Yagi, T | 1 |
| Ito, D | 1 |
| Kosakai, A | 1 |
| Hayashi, K | 1 |
| Shouji, M | 1 |
| Nakanishi, A | 1 |
| Suzuki, N | 1 |
| Mizuno, Y | 1 |
| Mizushima, N | 1 |
| Amagai, M | 1 |
| Uchiyama, Y | 1 |
| Mochizuki, H | 1 |
| Okano, H | 1 |
| Song, S | 1 |
| Jang, S | 1 |
| Park, J | 1 |
| Bang, S | 1 |
| Choi, S | 1 |
| Kwon, KY | 1 |
| Zhuang, X | 1 |
| Kim, E | 1 |
| Chung, J | 1 |
| Maita, C | 1 |
| Maita, H | 1 |
| Iguchi-Ariga, SM | 1 |
| Ariga, H | 1 |
| Cole, NB | 1 |
| Dieuliis, D | 1 |
| Leo, P | 1 |
| Mitchell, DC | 1 |
| Nussbaum, RL | 1 |
| Sheehan, JP | 1 |
| Swerdlow, RH | 1 |
| Parker, WD | 1 |
| Miller, SW | 1 |
| Davis, RE | 1 |
| Tuttle, JB | 1 |
24 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Parkinson Disease
| Article | Year |
|---|---|
Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.
Topics: Adenosine; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Humans; Kinetin; Mitochondria; Parkin | 2017 |
Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Humans; Membrane Potential, Mitochondrial; Mit | 2021 |
Differential expression of PARK2 splice isoforms in an in vitro model of dopaminergic-like neurons exposed to toxic insults mimicking Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Alternative Splicing; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell D | 2018 |
Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.
Topics: Antimycin A; Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; HeLa Cells; Hum | 2017 |
Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.
Topics: Animals; Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Ceramides; Enzyme Activation; Golgi A | 2018 |
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Topics: Adult; Aged; Benzodiazepinones; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Fibroblasts; Fluo | 2019 |
[The mechanism of PINK1 localization on the outer membrane of mitochondria].
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; HEK293 Cells; Humans; Mitochondria; Mitochondrial Membran | 2013 |
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Topics: Animals; Animals, Genetically Modified; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; | 2013 |
Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease.
Topics: Animals; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Computer Simulation; Disease Models, Anim | 2013 |
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
Topics: Adenosine Triphosphate; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Energy Metabolism; Glucose; Human | 2015 |
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Topics: alpha-Synuclein; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Fibroblasts; Gene Expre | 2015 |
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Topics: Biocatalysis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; HEK293 Cells; Humans; Intracellular Membran | 2015 |
Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease.
Topics: Adenosine Triphosphate; Aged; Asymptomatic Diseases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell | 2017 |
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Topics: Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Humans; Ionophores; Membrane Potent | 2010 |
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Topics: Animals; Biomarkers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dimethyl Sulfoxide; Fibroblasts; Flu | 2010 |
Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin.
Topics: Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Gene Knockdown Techniques; HEK293 Cells; HeLa | 2011 |
A novel protein degradation system in young-onset Parkinson's disease: mitophagy is a therapeutic target as a quality control for damaged mitochondria.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Humans; Ionophores; Mitochondria; Parkinson Dise | 2011 |
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.
Topics: Animals; Autophagy; Axonal Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Disease Models, Ani | 2012 |
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; HEK293 Cells; Humans; Insect | 2012 |
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Topics: Adult; Aged; alpha-Synuclein; Animals; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Hum | 2012 |
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
Topics: Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Drosophila melanogaster; | 2013 |
Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.
Topics: Amino Acid Substitution; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cysteine; Cytoplasm; Di | 2013 |
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Topics: alpha-Synuclein; Antimetabolites; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Deoxyglucose | 2008 |
Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Aged; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tr | 1997 |