carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Osteosarcoma in 5 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that treatment of human osteosarcoma cells with the protonophore m-chlorophenylhydrazone (CCCP) for 6 h induces MPT and mitochondrial swelling without significant cell death." | 1.31 | The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. ( Lim, ML; Minamikawa, T; Nagley, P, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Legros, F | 1 |
| Malka, F | 1 |
| Frachon, P | 1 |
| Lombès, A | 1 |
| Rojo, M | 1 |
| Zabłocki, K | 2 |
| Szczepanowska, J | 2 |
| Duszyński, J | 2 |
| Minamikawa, T | 2 |
| Williams, DA | 1 |
| Bowser, DN | 1 |
| Nagley, P | 2 |
| Lim, ML | 1 |
5 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Osteosarcoma
| Article | Year |
|---|---|
Organization and dynamics of human mitochondrial DNA.
Topics: Adult; Antibodies, Monoclonal; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; Child, P | 2004 |
Extracellular pH modifies mitochondrial control of capacitative calcium entry in Jurkat cells.
Topics: Anti-Bacterial Agents; Antimycin A; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Clonazepam; | 2005 |
Influence of a mitochondrial genetic defect on capacitative calcium entry and mitochondrial organization in the osteosarcoma cells.
Topics: Actins; Ataxia; Benzimidazoles; Calcium; Carbocyanines; Carbonyl Cyanide m-Chlorophenyl Hydrazone; C | 2004 |
Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells.
Topics: Aldehydes; Apoptosis; Benzimidazoles; Carbocyanines; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell | 1999 |
The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells.
Topics: Bone Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Membrane Permeability; Cytochrome c | 2001 |