carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Melanoma in 2 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on the functional mechanism of iron shown above, we further demonstrate that iron supplementation at a dosage used in iron-deficient patients is sufficient to maximize the anti-tumor effect of clinical ROS-inducing drugs to inhibit xenograft tumor growth and metastasis of melanoma cells through GSDME-dependent pyroptosis." | 1.48 | Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. ( Ai, YL; Chen, HZ; Cheng, K; Han, J; Liu, XS; Sun, RY; Wu, Q; Zhang, JY; Zhou, B; Zhou, D, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, B | 1 |
| Zhang, JY | 1 |
| Liu, XS | 1 |
| Chen, HZ | 1 |
| Ai, YL | 1 |
| Cheng, K | 1 |
| Sun, RY | 1 |
| Zhou, D | 1 |
| Han, J | 1 |
| Wu, Q | 1 |
| Knowles, AF | 1 |
| Kaplan, NO | 1 |
2 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Melanoma
| Article | Year |
|---|---|
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X P | 2018 |
Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
Topics: Adenosine Triphosphatases; Animals; Astrocytoma; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carcinom | 1980 |