carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Idiopathic Parkinson Disease in 24 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibition of complex I with the Parkinson's disease-inducing metabolite 1-methyl-4-phenylpyridinium (MPP+) similarly reduced the rate of recovery after carbachol." | 1.30 | Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. ( Davis, RE; Miller, SW; Parker, WD; Sheehan, JP; Swerdlow, RH; Tuttle, JB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 21 (87.50) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Osgerby, L | 1 |
| Lai, YC | 1 |
| Thornton, PJ | 1 |
| Amalfitano, J | 1 |
| Le Duff, CS | 1 |
| Jabeen, I | 1 |
| Kadri, H | 1 |
| Miccoli, A | 1 |
| Tucker, JHR | 1 |
| Muqit, MMK | 1 |
| Mehellou, Y | 1 |
| Ma, KY | 1 |
| Fokkens, MR | 1 |
| Reggiori, F | 1 |
| Mari, M | 1 |
| Verbeek, DS | 1 |
| La Cognata, V | 1 |
| Maugeri, G | 1 |
| D'Amico, AG | 1 |
| Saccone, S | 1 |
| Federico, C | 1 |
| Cavallaro, S | 1 |
| D'Agata, V | 1 |
| Xiao, B | 1 |
| Deng, X | 1 |
| Lim, GGY | 1 |
| Xie, S | 1 |
| Zhou, ZD | 1 |
| Lim, KL | 2 |
| Tan, EK | 1 |
| Back, MJ | 1 |
| Ha, HC | 1 |
| Fu, Z | 1 |
| Choi, JM | 1 |
| Piao, Y | 1 |
| Won, JH | 1 |
| Jang, JM | 1 |
| Shin, IC | 1 |
| Kim, DK | 1 |
| Bonello, F | 1 |
| Hassoun, SM | 1 |
| Mouton-Liger, F | 1 |
| Shin, YS | 1 |
| Muscat, A | 1 |
| Tesson, C | 1 |
| Lesage, S | 1 |
| Beart, PM | 1 |
| Brice, A | 1 |
| Krupp, J | 1 |
| Corvol, JC | 1 |
| Corti, O | 1 |
| Tai, HR | 1 |
| Jiang, CA | 1 |
| Burchell, VS | 1 |
| Nelson, DE | 1 |
| Sanchez-Martinez, A | 1 |
| Delgado-Camprubi, M | 1 |
| Ivatt, RM | 1 |
| Pogson, JH | 1 |
| Randle, SJ | 1 |
| Wray, S | 1 |
| Lewis, PA | 1 |
| Houlden, H | 1 |
| Abramov, AY | 1 |
| Hardy, J | 1 |
| Wood, NW | 1 |
| Whitworth, AJ | 1 |
| Laman, H | 1 |
| Plun-Favreau, H | 1 |
| Poliquin, PO | 1 |
| Chen, J | 1 |
| Cloutier, M | 1 |
| Trudeau, LÉ | 1 |
| Jolicoeur, M | 1 |
| Lee, S | 2 |
| Zhang, C | 1 |
| Liu, X | 2 |
| Norris, KL | 1 |
| Hao, R | 1 |
| Chen, LF | 1 |
| Lai, CH | 1 |
| Kapur, M | 1 |
| Shaughnessy, PJ | 1 |
| Chou, D | 1 |
| Yan, J | 1 |
| Taylor, JP | 1 |
| Engelender, S | 1 |
| West, AE | 1 |
| Yao, TP | 1 |
| Meissner, C | 1 |
| Lorenz, H | 1 |
| Hehn, B | 1 |
| Lemberg, MK | 1 |
| Koentjoro, B | 1 |
| Park, JS | 1 |
| Sue, CM | 1 |
| Vives-Bauza, C | 1 |
| Zhou, C | 1 |
| Huang, Y | 1 |
| Cui, M | 1 |
| de Vries, RL | 1 |
| Kim, J | 1 |
| May, J | 1 |
| Tocilescu, MA | 1 |
| Liu, W | 2 |
| Ko, HS | 1 |
| Magrané, J | 1 |
| Moore, DJ | 1 |
| Dawson, VL | 1 |
| Grailhe, R | 1 |
| Dawson, TM | 1 |
| Li, C | 1 |
| Tieu, K | 1 |
| Przedborski, S | 1 |
| Matsuda, N | 1 |
| Sato, S | 2 |
| Shiba, K | 1 |
| Okatsu, K | 1 |
| Saisho, K | 1 |
| Gautier, CA | 1 |
| Sou, YS | 1 |
| Saiki, S | 1 |
| Kawajiri, S | 1 |
| Sato, F | 1 |
| Kimura, M | 1 |
| Komatsu, M | 1 |
| Hattori, N | 3 |
| Tanaka, K | 1 |
| Yang, H | 1 |
| Zhou, X | 1 |
| Yang, L | 1 |
| Chen, Q | 1 |
| Zhao, D | 1 |
| Zuo, J | 1 |
| Hatano, T | 1 |
| Liu, S | 1 |
| Sawada, T | 1 |
| Yu, W | 1 |
| Silverio, G | 1 |
| Alapatt, P | 1 |
| Millan, I | 1 |
| Shen, A | 1 |
| Saxton, W | 1 |
| Kanao, T | 1 |
| Takahashi, R | 1 |
| Imai, Y | 1 |
| Lu, B | 1 |
| Kondapalli, C | 1 |
| Kazlauskaite, A | 1 |
| Zhang, N | 1 |
| Woodroof, HI | 1 |
| Campbell, DG | 1 |
| Gourlay, R | 1 |
| Burchell, L | 1 |
| Walden, H | 1 |
| Macartney, TJ | 1 |
| Deak, M | 1 |
| Knebel, A | 1 |
| Alessi, DR | 1 |
| Muqit, MM | 1 |
| Imaizumi, Y | 1 |
| Okada, Y | 1 |
| Akamatsu, W | 1 |
| Koike, M | 1 |
| Kuzumaki, N | 1 |
| Hayakawa, H | 1 |
| Nihira, T | 1 |
| Kobayashi, T | 1 |
| Ohyama, M | 1 |
| Takanashi, M | 1 |
| Funayama, M | 1 |
| Hirayama, A | 1 |
| Soga, T | 1 |
| Hishiki, T | 1 |
| Suematsu, M | 1 |
| Yagi, T | 1 |
| Ito, D | 1 |
| Kosakai, A | 1 |
| Hayashi, K | 1 |
| Shouji, M | 1 |
| Nakanishi, A | 1 |
| Suzuki, N | 1 |
| Mizuno, Y | 1 |
| Mizushima, N | 1 |
| Amagai, M | 1 |
| Uchiyama, Y | 1 |
| Mochizuki, H | 1 |
| Okano, H | 1 |
| Song, S | 1 |
| Jang, S | 1 |
| Park, J | 1 |
| Bang, S | 1 |
| Choi, S | 1 |
| Kwon, KY | 1 |
| Zhuang, X | 1 |
| Kim, E | 1 |
| Chung, J | 1 |
| Maita, C | 1 |
| Maita, H | 1 |
| Iguchi-Ariga, SM | 1 |
| Ariga, H | 1 |
| Cole, NB | 1 |
| Dieuliis, D | 1 |
| Leo, P | 1 |
| Mitchell, DC | 1 |
| Nussbaum, RL | 1 |
| Sheehan, JP | 1 |
| Swerdlow, RH | 1 |
| Parker, WD | 1 |
| Miller, SW | 1 |
| Davis, RE | 1 |
| Tuttle, JB | 1 |
24 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.
Topics: Adenosine; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Humans; Kinetin; Mitochondria; Parkin | 2017 |
Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Humans; Membrane Potential, Mitochondrial; Mit | 2021 |
Differential expression of PARK2 splice isoforms in an in vitro model of dopaminergic-like neurons exposed to toxic insults mimicking Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Alternative Splicing; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell D | 2018 |
Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.
Topics: Antimycin A; Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; HeLa Cells; Hum | 2017 |
Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.
Topics: Animals; Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Ceramides; Enzyme Activation; Golgi A | 2018 |
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Topics: Adult; Aged; Benzodiazepinones; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Fibroblasts; Fluo | 2019 |
[The mechanism of PINK1 localization on the outer membrane of mitochondria].
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; HEK293 Cells; Humans; Mitochondria; Mitochondrial Membran | 2013 |
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Topics: Animals; Animals, Genetically Modified; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; | 2013 |
Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease.
Topics: Animals; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Computer Simulation; Disease Models, Anim | 2013 |
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
Topics: Adenosine Triphosphate; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Energy Metabolism; Glucose; Human | 2015 |
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Topics: alpha-Synuclein; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Fibroblasts; Gene Expre | 2015 |
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Topics: Biocatalysis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; HEK293 Cells; Humans; Intracellular Membran | 2015 |
Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease.
Topics: Adenosine Triphosphate; Aged; Asymptomatic Diseases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell | 2017 |
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Topics: Autophagy; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Humans; Ionophores; Membrane Potent | 2010 |
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Topics: Animals; Biomarkers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dimethyl Sulfoxide; Fibroblasts; Flu | 2010 |
Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin.
Topics: Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Gene Knockdown Techniques; HEK293 Cells; HeLa | 2011 |
A novel protein degradation system in young-onset Parkinson's disease: mitophagy is a therapeutic target as a quality control for damaged mitochondria.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Humans; Ionophores; Mitochondria; Parkinson Dise | 2011 |
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.
Topics: Animals; Autophagy; Axonal Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Disease Models, Ani | 2012 |
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; HEK293 Cells; Humans; Insect | 2012 |
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Topics: Adult; Aged; alpha-Synuclein; Animals; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Female; Hum | 2012 |
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
Topics: Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Drosophila melanogaster; | 2013 |
Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.
Topics: Amino Acid Substitution; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cysteine; Cytoplasm; Di | 2013 |
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Topics: alpha-Synuclein; Antimetabolites; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Deoxyglucose | 2008 |
Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Aged; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tr | 1997 |