carbonyl cyanide m-chlorophenyl hydrazone has been researched along with Colonic Neoplasms in 7 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The formation of the glutathione S-conjugate of monochlorobimane (GSH-bimane) in human colon adenocarcinoma cells was identified by HPLC-fluorimetry and its transport from the cells was found to be temperature-sensitive, saturable and ATP-dependent." | 3.69 | Active transport of glutathione S-conjugate in human colon adenocarcinoma cells. ( Wong, KP; Zhang, K, 1996) |
| " The analogs 2a and 2b have submicromolar IC(50) values towards human HCT-116 colon cancer cells but are far less toxic to human non-malignant CRL-1790 colon cells." | 1.39 | Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells. ( Bandy, B; Das, U; Dimmock, JR; Helal, M; Islam, A; Nazarali, AJ, 2013) |
| "We now report that differentiated HT-29 colon cancer cells have pronounced plasma membrane PMCA4 localization, consistent with augmented calcium efflux." | 1.35 | Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells. ( Aung, CS; Monteith, GR; Peters, AA; Plowman, G; Roberts-Thomson, SJ; Ye, W, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Helal, M | 1 |
| Das, U | 1 |
| Bandy, B | 1 |
| Islam, A | 1 |
| Nazarali, AJ | 1 |
| Dimmock, JR | 1 |
| Weidner, C | 1 |
| Rousseau, M | 1 |
| Micikas, RJ | 1 |
| Fischer, C | 1 |
| Plauth, A | 1 |
| Wowro, SJ | 1 |
| Siems, K | 1 |
| Hetterling, G | 1 |
| Kliem, M | 1 |
| Schroeder, FC | 1 |
| Sauer, S | 1 |
| Aung, CS | 1 |
| Ye, W | 1 |
| Plowman, G | 1 |
| Peters, AA | 1 |
| Monteith, GR | 1 |
| Roberts-Thomson, SJ | 1 |
| Izeradjene, K | 1 |
| Douglas, L | 1 |
| Tillman, DM | 1 |
| Delaney, AB | 1 |
| Houghton, JA | 1 |
| Reers, M | 1 |
| Smiley, ST | 1 |
| Mottola-Hartshorn, C | 1 |
| Chen, A | 1 |
| Lin, M | 1 |
| Chen, LB | 1 |
| Zhang, K | 1 |
| Wong, KP | 1 |
| Gauthier, T | 1 |
| Denis-Pouxviel, C | 1 |
| Paris, H | 1 |
| Murat, JC | 1 |
7 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and Colonic Neoplasms
| Article | Year |
|---|---|
Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells.
Topics: Animals; Colonic Neoplasms; Glutathione; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Mi | 2013 |
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle Check | 2016 |
Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells.
Topics: Apoptosis; Calcium; Calcium Signaling; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Differentiati | 2009 |
Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; | 2005 |
Mitochondrial membrane potential monitored by JC-1 dye.
Topics: Animals; Benzimidazoles; Biological Transport; Carbocyanines; Carbonyl Cyanide m-Chlorophenyl Hydraz | 1995 |
Active transport of glutathione S-conjugate in human colon adenocarcinoma cells.
Topics: 2,4-Dinitrophenol; Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Agents; Biological Transpo | 1996 |
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Differentiat | 1989 |