carbonyl cyanide m-chlorophenyl hydrazone has been researched along with African Sleeping Sickness in 2 studies
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.
CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with protozoans of the species Trypanosoma brucei gambiense and T." | 1.35 | The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. ( Lanteri, CA; Meshnick, SR; Tidwell, RR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lanteri, CA | 1 |
| Tidwell, RR | 1 |
| Meshnick, SR | 1 |
| Lomo, PO | 1 |
| Makawiti, DW | 1 |
| Konji, VN | 1 |
2 other studies available for carbonyl cyanide m-chlorophenyl hydrazone and African Sleeping Sickness
| Article | Year |
|---|---|
The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
Topics: Animals; Benzamidines; Blood; Flow Cytometry; Fluorescent Dyes; Membrane Potentials; Mice; Mitochond | 2008 |
Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine.
Topics: Adenosine Diphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Glutamates; Glutamic Acid | 1993 |