Page last updated: 2024-11-08

carbon tetrachloride and Non-alcoholic Fatty Liver Disease

carbon tetrachloride has been researched along with Non-alcoholic Fatty Liver Disease in 45 studies

Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.

Non-alcoholic Fatty Liver Disease: Fatty liver finding without excessive ALCOHOL CONSUMPTION.

Research Excerpts

ExcerptRelevanceReference
"Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively."5.48Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018)
" Dangfei Liganning capsules potentially decrease this toxic susceptibility and alleviate liver injury in non-alcoholic fatty liver."5.37Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity. ( Ge, YL; Ji, G; Li, DF; Liu, P; Liu, T; Mao, ZM; Song, HY; Yang, LL; Zhang, L; Zhang, XQ; Zheng, PY, 2011)
"Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice."4.31Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023)
"Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function."3.91The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis. ( Buson, A; Deodhar, M; Findlay, AD; Foot, JS; Greco, A; Jarolimek, W; Joshi, A; Moses, J; Perryman, L; Rayner, B; Schilter, H; Townsend, S; Turner, CI; Yow, TT; Zahoor, A; Zhou, W, 2019)
" By establishing a simple method of discriminating between apoptosis and necrosis in the liver, we found that necrosis occurred prior to apoptosis at the onset of steatohepatitis in the choline-deficient, ethionine-supplemented (CDE) diet model."3.91Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. ( Imai, H; Koumura, T; Matsuoka, M; Miyajima, A; Nakano, H; Nakasone, M; Okochi, H; Sakamoto, T; Tanaka, M; Tsuchiya, Y; Tsurusaki, S; Yuet-Yin Kok, C, 2019)
" C57BL/6N mice were fed a high-fat diet (HFD) to develop obesity and were either administered carbon tetrachloride (CCl4 ) eight times (0."3.79A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice. ( Ishikawa, F; Kado, S; Kano, M; Kobayashi, T; Kubota, N; Masuoka, N; Miyazaki, K; Nagata, Y, 2013)
"To study the mechanism of liver injury induced by carbon tetrachloride (CCl(4)) in rats with non-alcoholic fatty liver disease (NAFLD), and the therapeutic effects of the extract mixture of Dangyao (Swertia pseudochinensis Hara) and Shuifeiji (Silybum marianum Gaertn) on NAFLD rats with liver injury."3.78[Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease]. ( Ji, G; Li, DF; Liu, P; Liu, T; Mao, ZM; Song, HY; Yang, LL; Zheng, PY, 2012)
"Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia."2.66Rodent Models of Nonalcoholic Fatty Liver Disease. ( Gao, L; Xu, J; Zhong, F; Zhou, X, 2020)
"Liver fibrosis is a leading indicator for increased mortality and long-term comorbidity in NASH."1.91Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling. ( Chen, S; Cheng, J; Dong, L; Fu, R; Han, P; Li, R; Li, S; Liu, Z; Pei, H; Shen, X; Song, G; Song, Y; Wang, H; Wei, J; Wu, J; Yao, Q; Zhang, G; Zhang, S; Zhao, Y; Zhu, C; Zhu, J, 2023)
"Non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis results in the encapsulation of injured liver parenchyma by a collagenous scar mainly imputable to hepatic stellate cells' activation."1.72Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis. ( Alisi, A; Bianchi, M; Braghini, MR; Comparcola, D; Condorelli, AG; Conti, LA; Crudele, A; De Stefanis, C; Gurrado, F; Lioci, G; Mosca, A; Nobili, R; Panera, N; Sartorelli, MR; Scoppola, V; Smeriglio, A; Svegliati-Baroni, G; Trombetta, D, 2022)
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, and it is closely associated to obesity, type 2 diabetes mellitus, and dyslipidemia."1.62Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice. ( Appendino, G; Carmona-Hidalgo, B; García-Martín, A; González-Mariscal, I; Muñoz, E; Prados, ME; Ruiz-Pino, F; Tena-Sempere, M, 2021)
"Liver fibrosis was attenuated in mice with Tgr5 depletion."1.62Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis. ( Bian, H; Gao, X; Huang, F; Jia, W; Jiang, R; Liu, P; Liu, Z; Qiu, J; Rajani, C; Sun, B; Wang, X; Wu, Y; Xie, G; Zhang, X; Zhao, A; Zhao, S; Zheng, X, 2021)
"Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to liver injury caused by stimulants such as drugs and poisons."1.51Jiang-Zhi granules decrease sensitivity to low-dose CCl ( Song, H; Yang, L; Zheng, P; Zhou, Y, 2019)
"Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease."1.51New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019)
"Furthermore, AZGP1 alleviated NAFLD by blocking TNF-α-mediated inflammation and intracellular lipid deposition, promoting proliferation, and inhibiting apoptosis in LO2 cells."1.51Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. ( Li, ZH; Liu, T; Luo, SZ; Luo, X; Wu, JC; Xu, MY, 2019)
"Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively."1.48Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018)
"We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main outcome)."1.46Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Dongiovanni, P; Fargion, S; Ferri, N; Fracanzani, AL; Giordano, D; Grimaudo, S; Maggioni, M; Meroni, M; Petta, S; Pierantonelli, I; Pipitone, RM; Ruscica, M; Rychlicki, C; Svegliati-Baroni, G; Valenti, L, 2017)
"Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent form of human hepatic disease and feeding mice a high-fat, high-caloric (HFHC) diet is a standard model of NAFLD."1.42Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet. ( Anderson, K; Cheverud, J; Green, RM; Hall, RA; Jafari, N; Kenney-Hunt, J; Lammert, F; Pasricha, S, 2015)
"Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear."1.42Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015)
"Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use."1.40Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model. ( Chanderasekharan, H; Chheda, TK; Madanahalli, JR; Marikunte, VV; Moolemath, Y; Oommen, AM; Sadasivan, SK; Shivakumar, P, 2014)
"Our results showed that the induced NAFLD and insulin resistance (IR) were accompanied with hyperglycemia and hyperlipidemia and lowered brain glucose level with elevated ATPase activity, prooxidant status (TBARS level, xanthine oxidase and cytochrome 2E1 activities), and inflammatory markers."1.37Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. ( Ghareeb, DA; Hafez, HS; Hussien, HM; Kabapy, NF, 2011)
"Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver function."1.37Liver fatty acid composition in mice with or without nonalcoholic fatty liver disease. ( Cao, Y; Fu, Y; Guo, G; Wang, X; Zhang, X, 2011)
" Dangfei Liganning capsules potentially decrease this toxic susceptibility and alleviate liver injury in non-alcoholic fatty liver."1.37Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity. ( Ge, YL; Ji, G; Li, DF; Liu, P; Liu, T; Mao, ZM; Song, HY; Yang, LL; Zhang, L; Zhang, XQ; Zheng, PY, 2011)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's24 (53.33)24.3611
2020's21 (46.67)2.80

Authors

AuthorsStudies
Chen, J2
Martin-Mateos, R1
Li, J3
Yin, Z1
Lu, X1
Glaser, KJ1
Mounajjed, T1
Yashiro, H1
Siegelman, J1
Winkelmann, CT1
Wang, J1
Ehman, RL1
Shah, VH1
Yin, M1
Márquez-Quiroga, LV1
Arellanes-Robledo, J1
Vásquez-Garzón, VR1
Villa-Treviño, S1
Muriel, P1
Wu, B1
Zheng, X2
Li, X1
Wang, C1
Li, L1
Tang, Z1
Cui, H1
Li, Z2
Chen, L1
Ma, X1
Wang, D1
Tan, KS1
Zeng, W1
Li, S2
Wang, Y3
Xu, F1
Tan, W1
Panera, N1
Braghini, MR1
Crudele, A1
Smeriglio, A1
Bianchi, M1
Condorelli, AG1
Nobili, R1
Conti, LA1
De Stefanis, C1
Lioci, G1
Gurrado, F1
Comparcola, D1
Mosca, A1
Sartorelli, MR1
Scoppola, V1
Svegliati-Baroni, G2
Trombetta, D1
Alisi, A1
Song, Y1
Wei, J1
Li, R1
Fu, R1
Han, P1
Wang, H1
Zhang, G1
Chen, S1
Liu, Z2
Zhao, Y1
Zhu, C1
Zhu, J1
Zhang, S1
Pei, H1
Cheng, J1
Wu, J1
Dong, L1
Song, G1
Shen, X1
Yao, Q1
Oates, JR1
Sawada, K1
Giles, DA1
Alarcon, PC1
Damen, MSMA1
Szabo, S1
Stankiewicz, TE1
Moreno-Fernandez, ME1
Divanovic, S1
Pickich, MB1
Hargrove, MW1
Phillips, CN1
Healy, JC1
Moore, AN1
Roberts, MD1
Martin, JS1
Yang, L1
Zhou, Y1
Song, H1
Zheng, P2
Maeso-Díaz, R1
Boyer-Diaz, Z1
Lozano, JJ1
Ortega-Ribera, M1
Peralta, C1
Bosch, J1
Gracia-Sancho, J1
Liu, T3
Luo, X1
Li, ZH1
Wu, JC1
Luo, SZ1
Xu, MY1
Zhong, F1
Zhou, X2
Xu, J1
Gao, L1
Fishman, P1
Cohen, S1
Itzhak, I1
Amer, J1
Salhab, A1
Barer, F1
Safadi, R1
Hammoutene, A1
Biquard, L1
Lasselin, J1
Kheloufi, M1
Tanguy, M1
Vion, AC1
Mérian, J1
Colnot, N1
Loyer, X1
Tedgui, A1
Codogno, P1
Lotersztajn, S1
Paradis, V1
Boulanger, CM1
Rautou, PE1
Campos, G1
Schmidt-Heck, W1
De Smedt, J1
Widera, A1
Ghallab, A1
Pütter, L1
González, D1
Edlund, K1
Cadenas, C1
Marchan, R1
Guthke, R1
Verfaillie, C1
Hetz, C1
Sachinidis, A1
Braeuning, A1
Schwarz, M1
Weiß, TS1
Banhart, BK1
Hoek, J1
Vadigepalli, R1
Willy, J1
Stevens, JL1
Hay, DC1
Hengstler, JG1
Godoy, P1
Terkelsen, MK1
Bendixen, SM1
Hansen, D1
Scott, EAH1
Moeller, AF1
Nielsen, R1
Mandrup, S1
Schlosser, A1
Andersen, TL1
Sorensen, GL1
Krag, A1
Natarajan, KN1
Detlefsen, S1
Dimke, H1
Ravnskjaer, K1
Xu, Y1
Cai, Z1
Wang, X3
Ren, Q1
Zhou, Z2
Xie, R1
You, S1
Cui, AM1
Hashmi, SF1
Zhang, X3
Nadolny, C1
Chen, Y2
Chen, Q1
Bush, X1
Hurd, Z1
Ali, W1
Qin, G1
Deng, R1
Shi, W1
Zhang, C1
Jin, H1
Zeng, Z1
Wei, L1
Tian, Y1
Zhang, D1
Sun, G1
Xu, H2
Zhao, Q2
Song, N2
Yan, Z2
Lin, R1
Wu, S2
Jiang, L1
Hong, S2
Xie, J2
Zhou, H1
Wang, R2
Jiang, X2
Carmona-Hidalgo, B1
González-Mariscal, I1
García-Martín, A1
Prados, ME1
Ruiz-Pino, F1
Appendino, G1
Tena-Sempere, M1
Muñoz, E1
Xie, G1
Jiang, R1
Liu, P3
Zhao, A1
Wu, Y1
Huang, F1
Rajani, C1
Qiu, J1
Zhao, S1
Bian, H1
Gao, X2
Sun, B1
Jia, W1
Liu, C1
Dou, B1
Huang, J1
Huang, L2
Fan, S1
Huang, C1
Yang, S1
Wang, L2
Wang, T1
Yang, C1
Oldenburger, A1
Birk, G1
Schlepütz, M1
Broermann, A1
Stierstorfer, B1
Pullen, SS1
Rippmann, JF1
Liu, G1
Cui, Z1
Liu, H1
Gong, J1
Wang, A1
Zhang, J1
Ma, Q1
Huang, Y1
Piao, G1
Yuan, H1
Petta, S1
Valenti, L1
Ruscica, M1
Pipitone, RM1
Dongiovanni, P1
Rychlicki, C1
Ferri, N1
Cammà, C1
Fracanzani, AL1
Pierantonelli, I1
Di Marco, V1
Meroni, M1
Giordano, D1
Grimaudo, S1
Maggioni, M1
Cabibi, D1
Fargion, S1
Craxì, A1
Esrefoglu, M1
Cetin, A1
Taslidere, E1
Elbe, H1
Ates, B1
Tok, OE1
Aydin, MS1
Huang, P1
Kaluba, B1
Jiang, XL1
Chang, S1
Tang, XF1
Mao, LF1
Zhang, ZP1
Huang, FZ1
Schilter, H1
Findlay, AD1
Perryman, L1
Yow, TT1
Moses, J1
Zahoor, A1
Turner, CI1
Deodhar, M1
Foot, JS1
Zhou, W1
Greco, A1
Joshi, A1
Rayner, B1
Townsend, S1
Buson, A1
Jarolimek, W1
Yang, P1
Tsurusaki, S1
Tsuchiya, Y1
Koumura, T1
Nakasone, M1
Sakamoto, T1
Matsuoka, M1
Imai, H1
Yuet-Yin Kok, C1
Okochi, H1
Nakano, H1
Miyajima, A1
Tanaka, M1
Hu, M1
Xu, L1
An, S1
Tang, Y1
Liu, R1
Kubota, N1
Kado, S1
Kano, M1
Masuoka, N1
Nagata, Y1
Kobayashi, T1
Miyazaki, K1
Ishikawa, F1
Chheda, TK1
Shivakumar, P1
Sadasivan, SK1
Chanderasekharan, H1
Moolemath, Y1
Oommen, AM1
Madanahalli, JR1
Marikunte, VV1
Pasricha, S1
Kenney-Hunt, J1
Anderson, K1
Jafari, N1
Hall, RA1
Lammert, F1
Cheverud, J1
Green, RM1
Wree, A1
Johnson, CD1
Font-Burgada, J1
Eguchi, A1
Povero, D1
Karin, M1
Feldstein, AE1
Kopec, AK1
Joshi, N1
Luyendyk, JP1
Yano, S1
Hisanaga, A1
He, X1
He, J1
Sakao, K1
Hou, DX1
Carino, A1
Cipriani, S1
Marchianò, S1
Biagioli, M1
Santorelli, C1
Donini, A1
Zampella, A1
Monti, MC1
Fiorucci, S1
Baeck, C1
Wehr, A1
Karlmark, KR1
Heymann, F1
Vucur, M1
Gassler, N1
Huss, S1
Klussmann, S1
Eulberg, D1
Luedde, T1
Trautwein, C1
Tacke, F1
Ghareeb, DA1
Hafez, HS1
Hussien, HM1
Kabapy, NF1
Cao, Y1
Fu, Y1
Guo, G1
Mao, ZM2
Song, HY2
Yang, LL2
Li, DF2
Zheng, PY2
Ji, G2
Zhang, L1
Ge, YL1
Zhang, XQ1

Reviews

3 reviews available for carbon tetrachloride and Non-alcoholic Fatty Liver Disease

ArticleYear
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
    Biochemical pharmacology, 2022, Volume: 195

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas

2022
Rodent Models of Nonalcoholic Fatty Liver Disease.
    Digestion, 2020, Volume: 101, Issue:5

    Topics: Animals; Antioxidants; Carbon Tetrachloride; Cholesterol, Dietary; Combined Modality Therapy; Diet,

2020
Role of hemostatic factors in hepatic injury and disease: animal models de-liver.
    Journal of thrombosis and haemostasis : JTH, 2016, Volume: 14, Issue:7

    Topics: Animals; Bile Ducts; Blood Coagulation; Blood Coagulation Disorders; Carbon Tetrachloride; Chemical

2016

Other Studies

42 other studies available for carbon tetrachloride and Non-alcoholic Fatty Liver Disease

ArticleYear
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.
    Alcoholism, clinical and experimental research, 2021, Volume: 45, Issue:10

    Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Elasticity Ima

2021
Design, synthesis and activity evaluation of prodrug form JBP485 and Vitamin E for alleviation of NASH.
    Bioorganic & medicinal chemistry letters, 2022, 01-15, Volume: 56

    Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Design; Fibrosis;

2022
Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription.
    Life sciences, 2022, Mar-15, Volume: 293

    Topics: Amino Acid Sequence; Animals; Butyrylcholinesterase; Carbon Tetrachloride; Hep G2 Cells; Hepatocytes

2022
Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis.
    Nutrients, 2022, Sep-14, Volume: 14, Issue:18

    Topics: Animals; Carbon Tetrachloride; Fibrosis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Dis

2022
Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling.
    Hepatology (Baltimore, Md.), 2023, 11-01, Volume: 78, Issue:5

    Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Non-alcoholic F

2023
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla

2023
Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis.
    BMC research notes, 2019, Aug-09, Volume: 12, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemokine CCL5; Chemokine CX3CL1; Curcumin;

2019
Jiang-Zhi granules decrease sensitivity to low-dose CCl
    BMC complementary and alternative medicine, 2019, Aug-22, Volume: 19, Issue:1

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diet, High-Fat; Drugs, Chines

2019
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
    Cells, 2019, 09-10, Volume: 8, Issue:9

    Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li

2019
Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α.
    World journal of gastroenterology, 2019, Sep-28, Volume: 25, Issue:36

    Topics: Adipokines; Animals; Carbon Tetrachloride; Carrier Proteins; Diet, High-Fat; Disease Models, Animal;

2019
The A3 adenosine receptor agonist, namodenoson, ameliorates non‑alcoholic steatohepatitis in mice.
    International journal of molecular medicine, 2019, Volume: 44, Issue:6

    Topics: Actins; Adenosine A3 Receptor Agonists; Adiponectin; Animals; Carbon Tetrachloride; Disease Models,

2019
A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis.
    Journal of hepatology, 2020, Volume: 72, Issue:3

    Topics: Adult; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cells, Cult

2020
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
    Archives of toxicology, 2020, Volume: 94, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury, Ch

2020
Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.
    Hepatology (Baltimore, Md.), 2020, Volume: 72, Issue:6

    Topics: Animals; Biopsy; Capillaries; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease

2020
Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.
    Bioorganic chemistry, 2020, Volume: 99

    Topics: Administration, Oral; Animals; Benzimidazoles; Carbon Tetrachloride; Dose-Response Relationship, Dru

2020
Dysregulation of bile acids increases the risk for preterm birth in pregnant women.
    Nature communications, 2020, 04-30, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Animals; Bile Acids and Salts; Carbon Tetrachloride; Cholic Acid; Disease Models,

2020
Isolation and purification of immune cells from the liver.
    International immunopharmacology, 2020, Volume: 85

    Topics: Animals; Carbon Tetrachloride; Cell Separation; Chemical and Drug Induced Liver Injury; Collagenases

2020
AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.
    Nature communications, 2020, 11-16, Volume: 11, Issue:1

    Topics: Adenylate Kinase; Alanine Transaminase; Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Model

2020
Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 81

    Topics: Animals; Cannabis; Carbon Tetrachloride; Diet, High-Fat; Dronabinol; Gene Expression Regulation; Hep

2021
Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis.
    EBioMedicine, 2021, Volume: 66

    Topics: Animals; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Cell Line; Di

2021
Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:6

    Topics: Animals; Carbon Tetrachloride; Chenodeoxycholic Acid; Diet; Inflammation; Liver; Liver Cirrhosis; Ma

2021
Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc

2020
Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision-cut liver slices.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:3

    Topics: Adenosine Triphosphate; Animals; Blood Vessels; Carbon Tetrachloride; Endothelin-1; Ketanserin; Live

2021
Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:9

    Topics: AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Diet, High-Fat; Liver; Liver Cirrhosis

2021
Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
    The Journal of clinical endocrinology and metabolism, 2017, 08-01, Volume: 102, Issue:8

    Topics: Adult; Animals; Carbon Tetrachloride; Case-Control Studies; Diet, High-Fat; Female; Fibronectins; Ge

2017
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
    Bratislavske lekarske listy, 2017, Volume: 118, Issue:6

    Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi

2017
Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis.
    BioMed research international, 2018, Volume: 2018

    Topics: Animals; Bile Ducts; Blood Glucose; Body Weight; Carbon Tetrachloride; Cytokines; Hepatocytes; Infla

2018
The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Carbon Tetrachloride; Collagen; Cross-Linking Reagents; Elastin

2019
Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice.
    Molecular pharmaceutics, 2019, 01-07, Volume: 16, Issue:1

    Topics: Animals; Antioxidants; Brassica rapa; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury;

2019
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis.
    Cell death & disease, 2019, 06-18, Volume: 10, Issue:6

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Chromans; Cytokines; Diet; Ethionine; Ferroptosis; Hepatit

2019
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy.
    Nature communications, 2019, 07-05, Volume: 10, Issue:1

    Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Cell Line, Tumor; Disease Progression; Female; Gene Tr

2019
A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:7

    Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Anim

2013
Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.
    BMC gastroenterology, 2014, May-10, Volume: 14

    Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fast Foods; Female; Gene Expression Profiling

2014
Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.
    G3 (Bethesda, Md.), 2015, Jan-23, Volume: 5, Issue:4

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromosomes; Diet, High-Fat;

2015
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
    Cell death and differentiation, 2015, Volume: 22, Issue:12

    Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel

2015
Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:4

    Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Fruit; Heme Oxygenase-1; Interleuk

2017
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.
    Scientific reports, 2017, 02-16, Volume: 7

    Topics: 3T3-L1 Cells; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Biomarkers; Carbon Tetrachlorid

2017
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.
    Gut, 2012, Volume: 61, Issue:3

    Topics: Acute Disease; Animals; Aptamers, Nucleotide; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultur

2012
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
    Metabolic brain disease, 2011, Volume: 26, Issue:4

    Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Blood Glucose; Brain; Brain Chemistry; Car

2011
Liver fatty acid composition in mice with or without nonalcoholic fatty liver disease.
    Lipids in health and disease, 2011, Dec-14, Volume: 10

    Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Fatty Acids; Fatty Liver; Lipids; Liver; Male; Mice;

2011
[Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2012, Volume: 10, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug

2012
Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2011, Volume: 31, Issue:4

    Topics: Animals; Capsules; Carbon Tetrachloride; Caspase 3; Cytochrome P-450 CYP2E1; Drugs, Chinese Herbal;

2011