carbon tetrachloride has been researched along with Niemann-Pick Disease, Type C in 1 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ." | 1.38 | A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. ( Ebinuma, H; Hibi, T; Hiroi, S; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Miura, S; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Sugiyama, K; Suzuki, T; Teratani, T; Tominaga, S; Tomita, K; Yokoyama, H, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teratani, T | 1 |
| Tomita, K | 1 |
| Suzuki, T | 1 |
| Oshikawa, T | 1 |
| Yokoyama, H | 1 |
| Shimamura, K | 1 |
| Tominaga, S | 1 |
| Hiroi, S | 1 |
| Irie, R | 1 |
| Okada, Y | 1 |
| Kurihara, C | 1 |
| Ebinuma, H | 1 |
| Saito, H | 1 |
| Hokari, R | 1 |
| Sugiyama, K | 1 |
| Kanai, T | 1 |
| Miura, S | 1 |
| Hibi, T | 1 |
1 other study available for carbon tetrachloride and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cholesterol, Dietary; Disease Models, Animal; | 2012 |