carbon tetrachloride and Liver Neoplasms studies

Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.

Research Excerpts

Excerpt	Relevance	Reference
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease."	8.12	ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022)
" Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis."	7.75	Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009)
" 1,1,1-trichloroethane has been used widely, but only a few studies have been done suggesting a risk of multiple myeloma."	4.79	Organic solvents and cancer. ( Anttila, A; Hemminki, K; Lynge, E, 1997)
"Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis."	4.31	Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023)
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease."	4.12	ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022)
"We therefore examined the biochemical, histopathological and molecular effects of the 5-HT7 receptor agonist and antagonist on inflammatory liver fibrogenesis in animal models of progressive cirrhosis: a mouse model induced by carbon tetrachloride (CCl4) and in Hep3b cells."	3.85	Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Unal, D, 2017)
" Here we describe a syngeneic orthotopic HCC model in immunocompetent mice with liver cirrhosis induced by carbon tetrachloride (CCl4) that recapitulates key features of human HCC."	3.81	An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. ( Bardeesy, N; Chen, Y; Duda, DG; Fan, C; Hato, T; Huang, P; Jain, RK; Lauwers, GY; Ramjiawan, RR; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2015)
"Sorafenib--a broad kinase inhibitor--is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC."	3.80	Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. ( Chen, Y; Duda, DG; Duyverman, AM; Hiddingh, L; Huang, P; Huang, Y; Jain, RK; Koppel, C; Lauwers, GY; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2014)
" In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC."	3.79	Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013)
" In this study, the diethylnitrosamine (DEN)-induced liver tumor model and the chronic carbon tetrachloride (CCl(4))-induced liver fibrosis model were both used to investigate the role of STAT3 in liver tumorigenesis."	3.77	Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. ( Gao, B; Lafdil, F; Miller, AM; Niu, J; Park, O; Sun, Z; Wang, H; Wang, L; Yin, S, 2011)
" Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis."	3.75	Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009)
" After a 2-week recovery period liver cell proliferation was repeatedly induced by four or eight necrogenic doses of carbon tetrachloride (compensatory cell proliferation), or by four or eight treatments with three different liver mitogens, namely lead nitrate, ethylene dibromide and nafenopin (direct hyperplasia)."	3.68	Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. ( Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P, 1990)
" However, cytokeratin dimers and high-molecular-weight cytokeratin polymers were detected in liver tissue with histological evidence of coagulative necrosis induced by ischemia or carbon tetrachloride."	3.68	Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death. ( Chiu, JF; Fukuda, K; Kojiro, M, 1993)
"We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma."	3.67	An investigation into the association between liver damage and metastatic uveal melanoma. ( Albert, DM; Fournier, GA; Hatfield, RM; Pascal, SG; Saulenas, AM; Seddon, JM, 1985)
"Using a liver cancer dataset from the International Cancer Genome Consortium, we developed an extensive in silico screening that identified a cluster of adamalysins co-expressed in livers from patients with hepatocellular carcinoma (HCC)."	1.91	ADAMTS12 is a stromal modulator in chronic liver disease. ( Arpigny, E; Azar, F; Bonnier, D; Colige, A; Dekky, B; Kalebić, C; Legagneux, V; Monseur, C; Théret, N, 2023)
"Liver fibrosis is a common process resulting from various etiologies."	1.62	Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T ( Hu, Y; Li, Z; Liu, G; Ni, M; Wang, L; Wen, X; Yang, Y; Yu, H, 2021)
"TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis."	1.62	Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries. ( Ge, G; Lin, M; Peng, YJ; Ren, Z; Shang, G; Tang, XT; Wang, SS; Yin, X; Yuan, J; Zhou, BO, 2021)
"GSTZ1 deficiency significantly promoted hepatoma cell proliferation and aerobic glycolysis in HCC cells."	1.51	GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. ( Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y, 2019)
"There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents."	1.46	Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017)
"The incidence of liver cancer is higher in men than in women."	1.43	Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016)
"Liver fibrosis is characterized by significant accumulation of extracellular matrix (ECM) proteins, mainly fibrillar collagen-I, as a result of persistent liver injury."	1.43	Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. ( Arriazu, E; Chen, Y; Conde de la Rosa, L; Ge, X; Magdaleno, F; Nieto, N; Ruiz de Galarreta, M, 2016)
"The progression of liver fibrosis, an intrinsic response to chronic liver injury, is associated with hepatic hypoxia, angiogenesis, abnormal inflammation, and significant matrix deposition, leading to the development of cirrhosis and hepatocellular carcinoma (HCC)."	1.43	Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. ( Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH, 2016)
"Hepatocarcinogenesis was significantly accelerated in the fibrotic livers compared to those of the control, significantly decreasing the life span of the mice."	1.43	Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. ( Ahn, SH; Cho, KJ; Chung, SI; Han, KH; Ju, HL; Kim, DY; Moon, H; Ro, SW, 2016)
"Autophagy is a regulatory pathway in liver fibrosis."	1.42	Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. ( Chen, YH; Huang, WP; Hung, TM; Lai, HS; Lee, PH; Lin, CW; Lin, YC; Yuan, RH, 2015)
"Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear."	1.42	Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015)
"A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used."	1.40	Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014)
"The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process."	1.40	Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. ( Gao, X; Han, D; Jin, J; Li, F; Luo, S; Lv, G; Ma, N; Qiao, Y; Wang, L; Wu, G; Xiang, Y; Xu, C; Xu, Y; Yan, B; Zhang, Y; Zhao, R, 2014)
"Liver fibrosis is caused by chemicals or viral infection."	1.38	Global analysis of DNA methylation in early-stage liver fibrosis. ( Iwasaki, N; Komatsu, Y; Ono, W; Waku, T; Yamaguchi, C; Yanagisawa, J, 2012)
"The levels of liver cancer markers, including α-fetoprotein and carcinoembryonic antigen, were substantially increased by NDEA treatment."	1.38	Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012)
"Here we show that hepatocellular carcinoma (HCC) arising spontaneously against a background of hepatitis occurred more frequently in Nucling-knockout (KO) mice than wild-type (WT) mice."	1.36	Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. ( Fukui, K; Hayashi, Y; Ishimaru, N; Kaji, R; Kim, SM; Liu, L; Mukai-Sakai, R; Sakai, T; Sano, N; Teng, X; Tran, NH, 2010)
"Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective."	1.36	Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010)
"Biologically based dose-response (BBDR) modeling of environmental pollutants can be utilized to inform the mode of action (MOA) by which compounds elicit adverse health effects."	1.36	Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. ( Conolly, RB; DeVito, MJ; El-Masri, HA; Luke, NS; Sams, R, 2010)
"To establish a rat model of liver cancer complicated by liver cirrhosis and explore the effects of the spleen on immune function in this model."	1.32	Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis. ( Liu, QG; Ma, QY; Pan, CE; Yang, W; Yao, YM; Zhang, M, 2003)
"Experimental observations were made on hepatic cancer induced with diethylnitrosamine (DEN) in guinea-pigs."	1.26	Immunological aspects of hepatocellular carcinoma in the guinea-pig. ( Desai, HN, 1976)
"In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers."	1.26	Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. ( McGuire, LJ; Poound, AW, 1978)
"The frequency of hepatomata was almost equal in the aflatoxin and aflatoxin-carbon tetrachloride group."	1.25	Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. ( Lageron, A; Lemonnier, FJ; Scotto, JM; Stralin, HG, 1975)
"One of 18 animals developed a hepatoma, but none of the mice given CCl4 in 0."	1.25	Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice. ( Inoue, S; Naito, Y; Takizawa, S; Watanabe, H, 1975)
" The LD50 of DMN on the other hand was decreased for 3 days, after which it returned to normal."	1.25	Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine. ( Lawson, TA; Pound, AW, 1975)
"3."	1.25	Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. ( Kwan, SW; Morris, HP; Webb, TE, 1968)

Research

Studies (163)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Adverse Events

Timeframe	Studies, this research(%)	All Research%
pre-1990	67 (41.10)	18.7374
1990's	10 (6.13)	18.2507
2000's	14 (8.59)	29.6817
2010's	51 (31.29)	24.3611
2020's	21 (12.88)	2.80

Authors	Studies
Humpton, TJ	1
Hall, H	1
Kiourtis, C	1
Nixon, C	1
Clark, W	1
Hedley, A	1
Shaw, R	1
Bird, TG	1
Blyth, K	1
Vousden, KH	1
Shaban, NZ	1
Yehia, SA	1
Awad, D	1
Shaban, SY	1
Saleh, SR	1
Márquez-Quiroga, LV	1
Arellanes-Robledo, J	1
Vásquez-Garzón, VR	1
Villa-Treviño, S	1
Muriel, P	1
Huang, YH	1
Lian, WS	1
Wang, FS	1
Wang, PW	1
Lin, HY	1
Tsai, MC	1
Yang, YL	1
Song, Z	2
Liu, X	1
Zhang, W	1
Luo, Y	1
Xiao, H	1
Liu, Y	3
Dai, G	1
Hong, J	1
Li, A	1
Li, J	4
Xian, L	1
Zheng, R	2
Wang, Y	6
Wan, X	1
Wang, T	2
Zhu, J	1
Gao, L	1
Wei, M	1
Zhang, D	1
Chen, L	2
Wu, H	1
Ma, J	2
Li, L	2
Zhang, N	1
Xing, Q	1
He, L	1
Hong, F	1
Qin, S	1
Wu, B	1
Feng, J	1
Guo, J	1
Wang, J	2
Xiu, G	1
Xu, J	3
Ning, K	1
Ling, B	1
Fu, Q	1
Cohen, SM	1
Bevan, C	1
Gollapudi, B	1
Klaunig, JE	1
Dekky, B	1
Azar, F	1
Bonnier, D	1
Monseur, C	1
Kalebić, C	1
Arpigny, E	1
Colige, A	1
Legagneux, V	1
Théret, N	1
Wang, B	1
Kaufmann, B	1
Mogler, C	1
Zhong, S	1
Yin, Y	1
Cheng, Z	1
Schmid, RM	1
Friess, H	1
Hüser, N	1
von Figura, G	1
Hartmann, D	1
Wang, Q	1
Yang, Y	4
Lei, C	1
Yang, F	2
Liang, L	1
Chen, C	2
Xia, J	1
Wang, K	2
Tang, N	1
Kurahashi, T	1
Yoshida, Y	1
Ogura, S	1
Egawa, M	1
Furuta, K	1
Hikita, H	1
Kodama, T	1
Sakamori, R	1
Kiso, S	1
Kamada, Y	1
Wang, IC	1
Eguchi, H	1
Morii, E	1
Doki, Y	1
Mori, M	1
Kalinichenko, VV	1
Tatsumi, T	1
Takehara, T	1
Lu, ZN	1
Luo, Q	1
Zhao, LN	1
Shi, Y	1
Wang, N	1
Wang, L	4
Han, ZG	1
She, S	1
Wu, X	1
Zheng, D	1
Pei, X	1
Sun, Y	2
Zhou, J	1
Nong, L	1
Guo, C	1
Lv, P	1
Song, Q	1
Zheng, C	1
Liang, W	1
Huang, S	1
Li, Q	1
Liu, Z	2
Li, Y	2
Zhang, Y	3
Kong, W	1
You, H	1
Xi, J	1
Campos, G	1
Schmidt-Heck, W	1
De Smedt, J	1
Widera, A	1
Ghallab, A	1
Pütter, L	1
González, D	1
Edlund, K	1
Cadenas, C	1
Marchan, R	1
Guthke, R	1
Verfaillie, C	1
Hetz, C	1
Sachinidis, A	1
Braeuning, A	1
Schwarz, M	1
Weiß, TS	1
Banhart, BK	1
Hoek, J	1
Vadigepalli, R	1
Willy, J	1
Stevens, JL	1
Hay, DC	1
Hengstler, JG	1
Godoy, P	1
Lin, YH	1
Zhang, S	2
Zhu, M	1
Lu, T	1
Chen, K	1
Wen, Z	1
Wang, S	2
Xiao, G	1
Luo, D	1
Jia, Y	1
MacConmara, M	1
Hoshida, Y	3
Singal, AG	1
Yopp, A	1
Zhu, H	1
Jung, YS	1
Stratton, SA	1
Lee, SH	1
Kim, MJ	1
Jun, S	1
Zhang, J	1
Zheng, B	1
Cervantes, CL	1
Cha, JH	1
Barton, MC	1
Park, JI	1
Kikuchi, A	1
Singh, S	2
Poddar, M	2
Nakao, T	1
Schmidt, HM	1
Gayden, JD	1
Sato, T	1
Arteel, GE	1
Monga, SP	2
Ni, M	1
Yu, H	1
Wen, X	1
Liu, G	1
Hu, Y	2
Li, Z	2
Wang, SS	1
Tang, XT	1
Lin, M	1
Yuan, J	1
Peng, YJ	1
Yin, X	1
Shang, G	1
Ge, G	1
Ren, Z	1
Zhou, BO	1
Sun, M	1
Li, W	2
Liu, C	2
Jiang, Z	1
Gu, P	1
Wang, W	1
You, R	1
Ba, Q	1
Li, X	3
Wang, H	4
Sydor, S	1
Manka, P	1
Best, J	1
Jafoui, S	1
Sowa, JP	1
Zoubek, ME	1
Hernandez-Gea, V	1
Cubero, FJ	1
Kälsch, J	1
Vetter, D	1
Fiel, MI	1
Bian, CB	1
Nelson, LJ	1
Moshage, H	1
Faber, KN	1
Paul, A	1
Baba, HA	1
Gerken, G	1
Friedman, SL	1
Canbay, A	1
Bechmann, LP	1
Ali, MM	1
H Borai, I	1
Ghanem, HM	1
H Abdel-Halim, A	1
Mousa, FM	1
Wu, Q	1
Chen, JX	1
Chen, Y	5
Cai, LL	1
Wang, XZ	1
Guo, WH	1
Zheng, JF	1
Dou, C	1
Tu, K	1
Zhang, H	3
Yaqoob, U	1
Wen, J	1
van Deursen, J	1
Sicard, D	1
Tschumperlin, D	1
Zou, H	1
Huang, WC	1
Urrutia, R	1
Shah, VH	1
Kang, N	1
Preziosi, M	1
Delire, B	1
Henriet, P	1
Lemoine, P	1
Leclercq, IA	1
Stärkel, P	1
D'Souza, AM	1
Jiang, Y	1
Cast, A	1
Valanejad, L	1
Wright, M	1
Lewis, K	1
Kumbaji, M	1
Shah, S	1
Smithrud, D	1
Karns, R	1
Shin, S	1
Timchenko, N	1
Lee, C	1
Kim, M	1
Lee, JH	1
Oh, J	1
Shin, HH	1
Lee, SM	1
Scherer, PE	1
Kwon, HM	1
Choi, JH	1
Park, J	1
Ito, Y	1
Nakajima, K	1
Masubuchi, Y	1
Kikuchi, S	1
Saito, F	1
Akahori, Y	1
Jin, M	1
Yoshida, T	1
Shibutani, M	1
Manco, R	1
Clerbaux, LA	1
Verhulst, S	1
Bou Nader, M	1
Sempoux, C	1
Ambroise, J	1
Bearzatto, B	1
Gala, JL	1
Horsmans, Y	1
van Grunsven, L	1
Desdouets, C	1
Leclercq, I	1
Zuo, L	1
Zhu, Y	1
Hu, L	2
Pan, X	1
Li, K	1
Du, N	1
Huang, Y	2
Zhang, HE	1
Henderson, JM	1
Gorrell, MD	1
Hu, M	1
Xu, L	2
An, S	1
Tang, Y	2
Zhou, X	2
Liu, R	1
Huang, L	1
Seo, W	1
Gao, Y	1
He, Y	1
Sun, J	1
Xu, H	1
Feng, D	1
Park, SH	1
Cho, YE	1
Guillot, A	1
Ren, T	1
Wu, R	1
Kim, SJ	1
Hwang, S	1
Liangpunsakul, S	1
Niu, J	2
Gao, B	2
Papp, V	1
Rókusz, A	1
Dezső, K	1
Bugyik, E	1
Szabó, V	1
Pávai, Z	1
Paku, S	1
Nagy, P	1
Sengupta, D	1
Chowdhury, KD	1
Sarkar, A	1
Paul, S	1
Sadhukhan, GC	1
Luo, M	1
Huang, SX	1
Kuang, ZP	1
Luo, XL	1
Li, YD	1
Wu, JN	1
Xie, YA	1
Xu, B	1
Li, SH	1
Gao, SB	1
Ding, LH	1
Yin, ZY	1
Lin, X	1
Feng, ZJ	1
Wang, XM	1
Jin, GH	1
Chappell, G	1
Kutanzi, K	1
Uehara, T	1
Tryndyak, V	1
Hong, HH	1
Hoenerhoff, M	1
Beland, FA	1
Rusyn, I	1
Pogribny, IP	1
Reiberger, T	2
Duyverman, AM	1
Huang, P	2
Samuel, R	2
Hiddingh, L	1
Roberge, S	2
Koppel, C	1
Lauwers, GY	3
Zhu, AX	2
Jain, RK	2
Duda, DG	2
Zhang, C	1
Wei, Q	1
Jiang, T	1
Shou, X	1
Li, ZQ	1
Wen, H	1
Fuchs, BC	1
Fujii, T	1
Wei, L	1
Yamada, S	1
McGinn, CM	1
DePeralta, DK	1
Chen, X	1
Kuroda, T	1
Lanuti, M	1
Schmitt, AD	1
Gupta, S	1
Crenshaw, A	1
Onofrio, R	1
Taylor, B	1
Winckler, W	1
Bardeesy, N	2
Caravan, P	1
Golub, TR	1
Tanabe, KK	1
Li, F	2
Ma, N	1
Zhao, R	1
Wu, G	1
Qiao, Y	1
Han, D	1
Xu, Y	1
Xiang, Y	1
Yan, B	1
Jin, J	1
Lv, G	1
Xu, C	1
Gao, X	1
Luo, S	1
Abdel-Monem, AR	1
Kandil, ZA	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma[NCT01356628]	Phase 2	23 participants (Actual)	Interventional	2011-05-25	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The number and nature of adverse events as a measure of safety and tolerability. Safety analysis will be conducted on all patients who receive at least one dose of PD-0332991 during the study period or follow-up. An adverse event is any unfavorable and unintended sign, symptom, syndrome or illness that develops during the period of observation in the clinical study, including a new illness or condition, worsening of a concomitant illnesses or condition, effect of the study medication or combination of 2 or more factors. (NCT01356628)
Timeframe: From date of randomization through study completion, assessed up to 100 months

Time to Disease Progression

Intervention	Adverse Events (Number)
PD-0332991	504

Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST Version 1.1), as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). The appearance of one or more new lesions is also considered progression. (NCT01356628)
Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

Article	Year
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma. Biochemical pharmacology, 2022, Volume: 195 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas	2022
Evaluation of the carcinogenicity of carbon tetrachloride. Journal of toxicology and environmental health. Part B, Critical reviews, 2023, 08-18, Volume: 26, Issue:6 Topics: Adrenal Gland Neoplasms; Animals; Carbon Tetrachloride; Humans; Lipids; Liver Neoplasms; Mice; Pheoc	2023
[Etiological mechanism of toxic hepatitis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1995, Feb-10, Volume: 84, Issue:2 Topics: Alcohol Drinking; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug-Relate	1995
Organic solvents and cancer. Cancer causes & control : CCC, 1997, Volume: 8, Issue:3 Topics: Alcohol Drinking; Benzene; Biliary Tract Neoplasms; Carbon Tetrachloride; Carcinogens; China; Cohort	1997
Carbon tetrachloride. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1979, Volume: 20 Topics: Air Pollutants; Animals; Carbon Tetrachloride; Carcinogens; Embryo, Mammalian; Embryo, Nonmammalian;	1979
Free radicals and tissue injury: fact and fiction. The British journal of cancer. Supplement, 1987, Volume: 8 Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fr	1987
Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals. Arzneimittel-Forschung, 1974, Volume: 24, Issue:2 Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemica	1974

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p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl Cell death and differentiation, 2022, Volume: 29, Issue:3 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Liver Regeneration	2022
A Titanium (IV)-Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines. International journal of molecular sciences, 2021, Oct-18, Volume: 22, Issue:20 Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical	2021
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of International journal of molecular sciences, 2022, Jan-31, Volume: 23, Issue:3 Topics: 3' Untranslated Regions; Angiopoietin-2; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; C	2022
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2. Journal of translational medicine, 2022, 04-05, Volume: 20, Issue:1 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fibrosis; Hepatic Stellate Cells; Humans;	2022
Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro. International immunopharmacology, 2022, Volume: 110 Topics: Aged; Aging; Animals; Canthaxanthin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Humans; Hydrog	2022
Identification of circular RNA biomarkers for Pien Tze Huang treatment of CCl4‑induced liver fibrosis using RNA‑sequencing. Molecular medicine reports, 2022, Volume: 26, Issue:4 Topics: Animals; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Case-Control Studies; Drugs, C	2022
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. Stem cell research & therapy, 2022, 10-04, Volume: 13, Issue:1 Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib	2022
ADAMTS12 is a stromal modulator in chronic liver disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:11 Topics: ADAMTS Proteins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatic Stellate Cells; Humans; Li	2023
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. PloS one, 2023, Volume: 18, Issue:11 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis;	2023
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of experimental & clinical cancer research : CR, 2019, Oct-30, Volume: 38, Issue:1 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet	2019
Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice. Cellular and molecular gastroenterology and hepatology, 2020, Volume: 9, Issue:3 Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cells, Cultured; Chemokine CCL2; Disease M	2020
The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers. Hepatology (Baltimore, Md.), 2020, Volume: 71, Issue:3 Topics: Animals; Aristolochic Acids; Bile Duct Neoplasms; Carbon Tetrachloride; Carcinoma, Hepatocellular; C	2020
PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. Journal of hepatology, 2020, Volume: 72, Issue:3 Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Polarity; C	2020
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease. Archives of toxicology, 2020, Volume: 94, Issue:1 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury, Ch	2020
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury. Gastroenterology, 2020, Volume: 158, Issue:6 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced	2020
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Hepatology (Baltimore, Md.), 2021, Volume: 73, Issue:2 Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carbon Tetrachloride; Carcinogenesis; Car	2021
Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury. The American journal of pathology, 2020, Volume: 190, Issue:10 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Movement; Hepatic Stellate Cells; Liv	2020
Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T Journal of magnetic resonance imaging : JMRI, 2021, Volume: 53, Issue:4 Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Neoplasms; Prospective Studies; Rats; Rats, Wi	2021
Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries. Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:3 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Cancer-Associated Fibroblasts; Ca	2021
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis. Clinical and translational medicine, 2021, Volume: 11, Issue:7 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Drugs, Chinese Herbal; Hepatic	2021
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury. Scientific reports, 2017, 08-14, Volume: 7, Issue:1 Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellula	2017
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 98 Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation;	2018
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation. Cell death & disease, 2018, 02-14, Volume: 9, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato	2018
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. Gastroenterology, 2018, Volume: 154, Issue:8 Topics: Animals; Benzoates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transdiffere	2018
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer. Gene expression, 2018, 08-22, Volume: 18, Issue:3 Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamin	2018
Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages. Cancer science, 2018, Volume: 109, Issue:7 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Male; Mice; Mice,	2018
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. Cellular and molecular gastroenterology and hepatology, 2018, Volume: 6, Issue:3 Topics: Animals; Benzenesulfonates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell	2018
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease. The Journal of pathology, 2019, Volume: 247, Issue:1 Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an	2019
Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 05-01, Volume: 169, Issue:1 Topics: Animals; Cadherins; Carbon Tetrachloride; Cell Proliferation; Cell Transformation, Neoplastic; Dieth	2019
Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury. Journal of hepatology, 2019, Volume: 70, Issue:6 Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Chemical and Dr	2019
PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation. Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:6 Topics: Acid Sensing Ion Channels; Animals; Calcium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Caspas	2019
Animal models for hepatocellular carcinoma. Biochimica et biophysica acta. Molecular basis of disease, 2019, 05-01, Volume: 1865, Issue:5 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Disease Models, Animal; Gene Editing; Huma	2019
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy. Nature communications, 2019, 07-05, Volume: 10, Issue:1 Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Cell Line, Tumor; Disease Progression; Female; Gene Tr	2019
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. Journal of hepatology, 2019, Volume: 71, Issue:5 Topics: Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carbon Tetrachl	2019
Expansion of hepatic stem cell compartment boosts liver regeneration. Stem cells and development, 2014, Jan-01, Volume: 23, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different	2014
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma. Biochimica et biophysica acta, 2014, Volume: 1840, Issue:1 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon T	2014
Two-stage model of chemically induced hepatocellular carcinoma in mouse. Oncology research, 2013, Volume: 20, Issue:11 Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat	2013
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43 Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa	2013
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. International journal of cancer, 2014, Jun-15, Volume: 134, Issue:12 Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas	2014
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; CD11b Antigen; Cell Line, Tumor; Cell Move	2014
Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:4 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Live	2014
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4 Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul	2014
Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. Journal of cellular and molecular medicine, 2014, Volume: 18, Issue:6 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Coculture Techniques; Hep	2014
A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl₄-induced injury on human hepatoma cell line (Huh7). Natural product research, 2015, Volume: 29, Issue:5 Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Fruit; Humans; Liver Neoplasms; M	2015
Mouse models of liver cancer. Methods in molecular biology (Clifton, N.J.), 2015, Volume: 1267 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4;	2015
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell death and differentiation, 2015, Volume: 22, Issue:12 Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel	2015
Amarogentin regulates self renewal pathways to restrict liver carcinogenesis in experimental mouse model. Molecular carcinogenesis, 2016, Volume: 55, Issue:7 Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation	2016
Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. The American journal of pathology, 2015, Volume: 185, Issue:9 Topics: Adult; Aged; Autophagy; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Humans;	2015
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nature protocols, 2015, Volume: 10, Issue:8 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Neoplasms; Liver Ne	2015
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma. Toxicology letters, 2015, Nov-04, Volume: 238, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatoc	2015
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma. The Journal of clinical investigation, 2015, Nov-02, Volume: 125, Issue:11 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia	2015
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Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC gastroenterology, 2016, 01-29, Volume: 16 Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; Ge	2016
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. Oncogene, 2016, 09-01, Volume: 35, Issue:35 Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Gene Knock-In Techniques; Hepatocytes;	2016
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. Molecular pharmaceutics, 2016, 07-05, Volume: 13, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyc	2016
A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity. PloS one, 2016, Volume: 11, Issue:5 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Biological Assay; Carbon Tetrachl	2016
Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. Journal of hepatology, 2016, Volume: 65, Issue:5 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cartilage Oligomeric Matrix Protein; Hepat	2016
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. Toxicology, 2016, Dec-12, Volume: 373 Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid	2016
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. International immunopharmacology, 2017, Volume: 43 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Fibrosis; Humans; Inflammation;	2017
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology, 2017, Volume: 152, Issue:6 Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H	2017
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis. Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:6 Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells	2008
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. The Journal of experimental medicine, 2009, Apr-13, Volume: 206, Issue:4 Topics: Animals; Carbon Tetrachloride; Disease Progression; Fibrinogens, Abnormal; Gene Deletion; Haptoglobi	2009
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Laboratory investigation; a journal of technical methods and pathology, 2009, Volume: 89, Issue:8 Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati	2009
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. International journal of cancer, 2010, Mar-01, Volume: 126, Issue:5 Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular;	2010
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models. Surgery, 2010, Volume: 147, Issue:5 Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injur	2010
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology, 2010, Volume: 138, Issue:5 Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell	2010
Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 115, Issue:1 Topics: Animals; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Proliferation; Cell Survival; Chemical	2010
Chemoprevention with aqueous extract of Butea monosperma flowers results in normalization of nuclear morphometry and inhibition of a proliferation marker in liver tumors. Phytotherapy research : PTR, 2011, Volume: 25, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Butea; Carbon Tetrachloride; Cell Nucleus; Cell Prolifer	2011
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The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:5 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cyclin-Dependen	2010
Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. The American journal of pathology, 2011, Volume: 179, Issue:2 Topics: Animals; Carbon Tetrachloride; DNA Damage; Fibrosis; Gene Deletion; Gene Expression Regulation, Neop	2011
Global analysis of DNA methylation in early-stage liver fibrosis. BMC medical genomics, 2012, Jan-27, Volume: 5 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chromosomes, Mammalian; Computational Biol	2012
The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:6 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbon Tetrachloride; Carc	2012
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[Transfection of human hepatic stimulator substance gene could protect BEL-7402 cells against hepatotoxins]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2004, Volume: 12, Issue:2 Topics: Apoptosis; Carbon Tetrachloride; Cytoprotection; Free Radicals; Growth Substances; Humans; Hydrogen	2004
The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4. Gene, 2006, Feb-15, Volume: 367 Topics: Animals; Base Sequence; Binding Sites; Carbon Tetrachloride; Carcinoma, Hepatocellular; Carrier Prot	2006
Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2005, Volume: 4, Issue:2 Topics: Animals; Carbon Tetrachloride; Contrast Media; Dextrans; Edetic Acid; Female; Ferrosoferric Oxide; H	2005
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Molecular carcinogenesis, 2006, Volume: 45, Issue:12 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Fibroblas	2006
[Cystic degeneration in liver injury induced by CCl4 in SD rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:22 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cysts; Disease Models, Animal	2006
Inhalation carcinogenicity and chronic toxicity of carbon tetrachloride in rats and mice. Inhalation toxicology, 2007, Volume: 19, Issue:13 Topics: Administration, Inhalation; Animals; Carbon Tetrachloride; Humans; Inhalation Exposure; Liver Neopla	2007
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu. Journal of agricultural and food chemistry, 2008, May-28, Volume: 56, Issue:10 Topics: Acetic Acid; Alcoholic Beverages; Animals; Antioxidants; Carbon Tetrachloride; Carcinoma, Hepatocell	2008
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats. Annals of the New York Academy of Sciences, 1983, Volume: 417 Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr	1983
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide. Gan, 1982, Volume: 73, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp	1982
Combined effects of fast-neutron irradiation and subcutaneously applied carbon tetrachloride or chloroform in C57Bl6 mice. Cancer letters, 1983, Volume: 20, Issue:1 Topics: Animals; Carbon Tetrachloride; Chloroform; Dose-Response Relationship, Drug; Dose-Response Relations	1983
Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene. Laboratory investigation; a journal of technical methods and pathology, 1983, Volume: 48, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Liver; Liver Neoplasms; Liver R	1983
[Changes in the nature of the hepatocyte proliferation in the liver and adenomatous nodes of mice in CC14-induced carcinogenesis]. Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 93, Issue:4 Topics: Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; DNA, Neoplasm; Liver; Liver Neoplasm	1982
Effects of various promoters on the induction of hyperplastic nodules in rat liver. Gan, 1980, Volume: 71, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia;	1980
Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death. Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:1 Topics: Animals; Carbon Tetrachloride; Cell Survival; Ischemia; Keratins; Liver; Liver Circulation; Liver Ne	1993
CCL4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels. Hepato-gastroenterology, 1994, Volume: 41, Issue:4 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Copper; Disease Models, Animal; Estradiol;	1994
[Establishment of a model of human gastric cancer with liver metastasis in nude mice]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 1993, Volume: 15, Issue:3 Topics: Adenocarcinoma, Mucinous; Animals; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Neopl	1993
Induction of hsp 70 in HepG2 cells in response to hepatotoxicants. Toxicology and applied pharmacology, 1996, Volume: 141, Issue:1 Topics: Bromobenzenes; Cadmium; Carbon Tetrachloride; Carcinogens; Cells, Cultured; Chromatography, Gas; Coc	1996
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine. Cancer research, 1997, Apr-01, Volume: 57, Issue:7 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response	1997
Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P). Cancer letters, 1997, Sep-16, Volume: 118, Issue:1 Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division;	1997
Summation of initiation activities of low doses of the non-hepatocarcinogen 1,2-dimethylhydrazine in the liver after carbon tetrachloride administration. Cancer letters, 2000, Jan-01, Volume: 148, Issue:1 Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; Cell Division;	2000
Change in expression of GBP28/adiponectin in carbon tetrachloride-administrated mouse liver. Biochemical and biophysical research communications, 2001, Jul-13, Volume: 285, Issue:2 Topics: Adiponectin; Animals; Antisense Elements (Genetics); Carbon Tetrachloride; Carcinoma, Hepatocellular	2001
Metabolic controls in precancerous liver-VII. Time course of loss of dietary feedback control of cholesterol synthesis during carcinogen treatment. European journal of cancer, 1976, Volume: 12, Issue:4 Topics: Animals; Carbon Tetrachloride; Cholesterol; Cholesterol, Dietary; Cyclohexanes; Ethionine; Feedback;	1976
Immunological aspects of hepatocellular carcinoma in the guinea-pig. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1976, Oct-30, Volume: 50, Issue:46 Topics: Animals; Antigens, Neoplasm; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Migration Inhibit	1976
Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. British journal of experimental pathology, 1975, Volume: 56, Issue:2 Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular	1975
Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice. Gan, 1975, Volume: 66, Issue:6 Topics: Age Factors; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism;	1975
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment. Gan, 1976, Volume: 67, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes;	1976
[Several patterns in the disdifferentiated changes in the activity of enzymes during blastomogenesis]. Vestnik Akademii meditsinskikh nauk SSSR, 1977, Issue:3 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Neoplasms, Experime	1977
Effect of carbon tetrachloride on carcinogenicity of petasites japonicus and transplantability of induced tumors. Gan, 1977, Volume: 68, Issue:6 Topics: Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Liver Neoplasms; Male; Neoplasm	1977
Influence of carbon tetrachloride on induction of tumours of the liver and kidneys in mice by netrosamines. British journal of cancer, 1978, Volume: 37, Issue:1 Topics: Animals; Carbon Tetrachloride; Drug Synergism; Kidney; Kidney Neoplasms; Lethal Dose 50; Liver; Live	1978
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. British journal of cancer, 1978, Volume: 37, Issue:4 Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Liver Regenera	1978
[Hepatic RNA resistance to enzymatic degradation in the process of hepatocarcinogenesis in rats]. Voprosy onkologii, 1978, Volume: 24, Issue:5 Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experime	1978
Promoting effect of carbon tetrachloride on azo-dye hepatocarcinogenesis in rats. Fukuoka igaku zasshi = Hukuoka acta medica, 1976, Volume: 67, Issue:4 Topics: Animals; Carbon Tetrachloride; Female; Liver Neoplasms; Methyldimethylaminoazobenzene; p-Dimethylami	1976
The phosphorylation of histones in rat liver undergoing malignant transformation. Cancer research, 1977, Volume: 37, Issue:3 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones;	1977
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens. Cancer research, 1976, Volume: 36, Issue:11 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic;	1976
Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine. British journal of cancer, 1975, Volume: 32, Issue:5 Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Hepatectomy; Kidney Neoplasms; Lethal Dose 50; L	1975
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats. Carcinogenesis, 1992, Volume: 13, Issue:8 Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu	1992
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. Carcinogenesis, 1990, Volume: 11, Issue:5 Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosa	1990
Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Adipates; Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzidines; Biological Availability; Carbon Tet	1987
Species differences in the interaction between CCl4 reactive metabolites and liver DNA or nuclear protein fractions. Carcinogenesis, 1989, Volume: 10, Issue:2 Topics: Animals; Carbon Tetrachloride; Cricetinae; DNA; Liver; Liver Neoplasms; Mesocricetus; Mice; Mice, In	1989
Protective value of a liver initiation-promotion regimen against the lethal effect of carbon tetrachloride in rats. Laboratory investigation; a journal of technical methods and pathology, 1989, Volume: 61, Issue:4 Topics: Animals; Carbon Tetrachloride; Liver; Liver Neoplasms; Male; Rats; Rats, Inbred F344	1989
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1985, Dec-17, Volume: 311, Issue:1152 Topics: Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Che	1985
Distribution pattern of liver matrix proteins, fibronectin and type I collagen, in DAB-induced hepatoma of rat. The Tohoku journal of experimental medicine, 1985, Volume: 146, Issue:4 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Collagen; Female; Fibronectins; Histocytoc	1985
Distribution of carbon tetrachloride-metabolite(s) to DNase I-sensitive and -resistant chromatin. Cancer letters, 1987, Volume: 37, Issue:3 Topics: Biotransformation; Carbon Tetrachloride; Chromatin; Deoxyribonuclease I; DNA Damage; Gene Expression	1987
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis. Carcinogenesis, 1987, Volume: 8, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv	1987
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis. Carcinogenesis, 1987, Volume: 8, Issue:2 Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms	1987
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats. Cancer genetics and cytogenetics, 1985, Volume: 17, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti	1985
An investigation into the association between liver damage and metastatic uveal melanoma. American journal of ophthalmology, 1985, Sep-15, Volume: 100, Issue:3 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cricetinae; Liver Diseases; L	1985
Early appearance of serum -fetoprotein as a function of dosage of various hepatocarcinogens. Cancer research, 1973, Volume: 33, Issue:3 Topics: Acetamides; Administration, Oral; Aflatoxins; Alpha-Globulins; Animals; Antilymphocyte Serum; Carbon	1973
Gamma-glutamyl transpeptidase: a clinical and experimental study. Digestion, 1972, Volume: 5, Issue:6 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon	1972
Polyribosomes in rat tissues. IV. On the abnormal dimer peak in hepatomas. Cancer research, 1966, Volume: 26, Issue:5 Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin; In Vitro Te	1966
Association of embryonic antigens with experimentally induced hepatic lesions in the rat. Cancer research, 1967, Volume: 27, Issue:11 Topics: Animals; Antigens; Cadmium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Embryo, Mammalian; Fema	1967
Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. The Biochemical journal, 1968, Volume: 109, Issue:4 Topics: Animals; Azaguanine; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin;	1968
[Synergic oncogenic effect of 2-N-fluorenylacetamide and carbon tetrachloride on rat liver]. Il Cancro, 1968, Volume: 21, Issue:1 Topics: Adenoma, Bile Duct; Amides; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Fluo	1968
[Synergic oncogenic action of 4-dimethylaminoazobenzole and carbon tetrachloride on rat liver]. Il Cancro, 1968, Volume: 21, Issue:1 Topics: Adenoma, Bile Duct; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Liver Cirrho	1968
[Analysis of tumor transformation in tissues. II. Biochemical dedifferentiation in the process of cancerogenesis (changes in creatine kinase and alkaline phosphatase as an example)]. Tsitologiia, 1970, Volume: 12, Issue:1 Topics: Alkaline Phosphatase; Animals; Anura; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transfor	1970
The covalent binding of metabolites of tritiated 2-methyl-4-dimethylamino-azobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats. European journal of cancer, 1967, Volume: 3, Issue:3 Topics: Aniline Compounds; Animals; Azo Compounds; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatect	1967
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride. Journal of the National Cancer Institute, 1970, Volume: 45, Issue:6 Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma,	1970
[Changes in creatine kinase activity in the presence of tumor processes in the liver]. Voprosy onkologii, 1970, Volume: 16, Issue:11 Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Creatine Kinase; Liver Neoplasms; Male; Mi	1970
The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats. Laboratory investigation; a journal of technical methods and pathology, 1971, Volume: 24, Issue:5 Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Ethanol; Fatty Li	1971
Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride. British journal of cancer, 1973, Volume: 27, Issue:6 Topics: Adenoma, Bile Duct; Animals; Bile Ducts; Carbon Tetrachloride; Drug Synergism; Kidney Neoplasms; Liv	1973
[Possible involvement of soluble anorganic pyrophosphatase in cancerification (rat liver following diethylnitrosamine and CCl4)]. Experimentelle Pathologie, 1972, Volume: 6, Issue:5 Topics: Animals; Carbon Tetrachloride; Enzyme Activation; Injections, Intraperitoneal; Liver; Liver Neoplasm	1972
The relation between experimental liver carcinoma and liver cirrhosis induced by simultaneous administration of p-dimethylaminoazobenzene and carbon tetrachloride. The Tohoku journal of experimental medicine, 1967, Volume: 92, Issue:1 Topics: Animals; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms; p-Dimethylamino	1967
Experimental liver carcinoma and liver cirrhosis induced by p-dimethylaminoazobenzene after preliminary carbon tetrachloride injections. The Tohoku journal of experimental medicine, 1967, Volume: 92, Issue:2 Topics: Animals; Azo Compounds; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms;	1967
The relation between experimental liver carcinoma and liver cirrhosis induced by successive administration of p-dimethylaminoazobenzene and carbon tetrachloride. The Tohoku journal of experimental medicine, 1967, Volume: 92, Issue:2 Topics: Animals; Body Weight; Carbon Tetrachloride; Hyperplasia; Liver; Liver Cirrhosis; Liver Neoplasms; p-	1967
The role of mutations in liver tumor induction in mice. Radiation research, 1972, Volume: 50, Issue:3 Topics: Animals; Carbon Tetrachloride; Female; Liver Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neopla	1972
Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine. Effect of prior treatment with 3-methylcholanthrene, phenobarbitone, dimethylformamide, diethyl-formamide, aminoacetonitrile, ethionine and carbon tetrachloride. Biochemical pharmacology, 1971, Volume: 20, Issue:12 Topics: Amides; Animals; Carbon Tetrachloride; Carcinogens; Dimethylformamide; Endoplasmic Reticulum; Ethion	1971
Development of tumor in the course of spontaneous restoration of carbon tetrachloride induced cirrhosis of the liver in rats. The Kurume medical journal, 1965, Volume: 12, Issue:1 Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Liver Neoplasms; Rats	1965
Tumor induction as a measure of genetic damage and repair in somatic cells of mice. Radiation research, 1968, Volume: 34, Issue:2 Topics: Animals; Carbon Tetrachloride; Chromosome Aberrations; Liver Neoplasms; Liver Regeneration; Mice; Ne	1968
Metabolic profiles during carcinogenesis and related conditions in hepatic tissue. Cancer research, 1965, Volume: 25, Issue:6 Topics: Amino Acids; Animals; Blood Proteins; Carbon Dioxide; Carbon Tetrachloride; Carcinogens; Hepatic Duc	1965

carbon tetrachloride and Liver Neoplasms