carbon tetrachloride has been researched along with Liver Neoplasms in 163 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Liver Neoplasms: Tumors or cancer of the LIVER.
Excerpt | Relevance | Reference |
---|---|---|
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
" Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 7.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
" 1,1,1-trichloroethane has been used widely, but only a few studies have been done suggesting a risk of multiple myeloma." | 4.79 | Organic solvents and cancer. ( Anttila, A; Hemminki, K; Lynge, E, 1997) |
"Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis." | 4.31 | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
"We therefore examined the biochemical, histopathological and molecular effects of the 5-HT7 receptor agonist and antagonist on inflammatory liver fibrogenesis in animal models of progressive cirrhosis: a mouse model induced by carbon tetrachloride (CCl4) and in Hep3b cells." | 3.85 | Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Unal, D, 2017) |
" Here we describe a syngeneic orthotopic HCC model in immunocompetent mice with liver cirrhosis induced by carbon tetrachloride (CCl4) that recapitulates key features of human HCC." | 3.81 | An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. ( Bardeesy, N; Chen, Y; Duda, DG; Fan, C; Hato, T; Huang, P; Jain, RK; Lauwers, GY; Ramjiawan, RR; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2015) |
"Sorafenib--a broad kinase inhibitor--is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC." | 3.80 | Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. ( Chen, Y; Duda, DG; Duyverman, AM; Hiddingh, L; Huang, P; Huang, Y; Jain, RK; Koppel, C; Lauwers, GY; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2014) |
" In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
" In this study, the diethylnitrosamine (DEN)-induced liver tumor model and the chronic carbon tetrachloride (CCl(4))-induced liver fibrosis model were both used to investigate the role of STAT3 in liver tumorigenesis." | 3.77 | Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. ( Gao, B; Lafdil, F; Miller, AM; Niu, J; Park, O; Sun, Z; Wang, H; Wang, L; Yin, S, 2011) |
" Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 3.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
" After a 2-week recovery period liver cell proliferation was repeatedly induced by four or eight necrogenic doses of carbon tetrachloride (compensatory cell proliferation), or by four or eight treatments with three different liver mitogens, namely lead nitrate, ethylene dibromide and nafenopin (direct hyperplasia)." | 3.68 | Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. ( Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P, 1990) |
" However, cytokeratin dimers and high-molecular-weight cytokeratin polymers were detected in liver tissue with histological evidence of coagulative necrosis induced by ischemia or carbon tetrachloride." | 3.68 | Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death. ( Chiu, JF; Fukuda, K; Kojiro, M, 1993) |
"We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma." | 3.67 | An investigation into the association between liver damage and metastatic uveal melanoma. ( Albert, DM; Fournier, GA; Hatfield, RM; Pascal, SG; Saulenas, AM; Seddon, JM, 1985) |
"Using a liver cancer dataset from the International Cancer Genome Consortium, we developed an extensive in silico screening that identified a cluster of adamalysins co-expressed in livers from patients with hepatocellular carcinoma (HCC)." | 1.91 | ADAMTS12 is a stromal modulator in chronic liver disease. ( Arpigny, E; Azar, F; Bonnier, D; Colige, A; Dekky, B; Kalebić, C; Legagneux, V; Monseur, C; Théret, N, 2023) |
"Liver fibrosis is a common process resulting from various etiologies." | 1.62 | Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T ( Hu, Y; Li, Z; Liu, G; Ni, M; Wang, L; Wen, X; Yang, Y; Yu, H, 2021) |
"TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis." | 1.62 | Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries. ( Ge, G; Lin, M; Peng, YJ; Ren, Z; Shang, G; Tang, XT; Wang, SS; Yin, X; Yuan, J; Zhou, BO, 2021) |
"GSTZ1 deficiency significantly promoted hepatoma cell proliferation and aerobic glycolysis in HCC cells." | 1.51 | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. ( Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y, 2019) |
"There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents." | 1.46 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017) |
"The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
"Liver fibrosis is characterized by significant accumulation of extracellular matrix (ECM) proteins, mainly fibrillar collagen-I, as a result of persistent liver injury." | 1.43 | Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. ( Arriazu, E; Chen, Y; Conde de la Rosa, L; Ge, X; Magdaleno, F; Nieto, N; Ruiz de Galarreta, M, 2016) |
"The progression of liver fibrosis, an intrinsic response to chronic liver injury, is associated with hepatic hypoxia, angiogenesis, abnormal inflammation, and significant matrix deposition, leading to the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.43 | Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. ( Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH, 2016) |
"Hepatocarcinogenesis was significantly accelerated in the fibrotic livers compared to those of the control, significantly decreasing the life span of the mice." | 1.43 | Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. ( Ahn, SH; Cho, KJ; Chung, SI; Han, KH; Ju, HL; Kim, DY; Moon, H; Ro, SW, 2016) |
"Autophagy is a regulatory pathway in liver fibrosis." | 1.42 | Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. ( Chen, YH; Huang, WP; Hung, TM; Lai, HS; Lee, PH; Lin, CW; Lin, YC; Yuan, RH, 2015) |
"Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
"A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
"The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process." | 1.40 | Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. ( Gao, X; Han, D; Jin, J; Li, F; Luo, S; Lv, G; Ma, N; Qiao, Y; Wang, L; Wu, G; Xiang, Y; Xu, C; Xu, Y; Yan, B; Zhang, Y; Zhao, R, 2014) |
"Liver fibrosis is caused by chemicals or viral infection." | 1.38 | Global analysis of DNA methylation in early-stage liver fibrosis. ( Iwasaki, N; Komatsu, Y; Ono, W; Waku, T; Yamaguchi, C; Yanagisawa, J, 2012) |
"The levels of liver cancer markers, including α-fetoprotein and carcinoembryonic antigen, were substantially increased by NDEA treatment." | 1.38 | Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
"Here we show that hepatocellular carcinoma (HCC) arising spontaneously against a background of hepatitis occurred more frequently in Nucling-knockout (KO) mice than wild-type (WT) mice." | 1.36 | Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. ( Fukui, K; Hayashi, Y; Ishimaru, N; Kaji, R; Kim, SM; Liu, L; Mukai-Sakai, R; Sakai, T; Sano, N; Teng, X; Tran, NH, 2010) |
"Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective." | 1.36 | Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010) |
"Biologically based dose-response (BBDR) modeling of environmental pollutants can be utilized to inform the mode of action (MOA) by which compounds elicit adverse health effects." | 1.36 | Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence. ( Conolly, RB; DeVito, MJ; El-Masri, HA; Luke, NS; Sams, R, 2010) |
"To establish a rat model of liver cancer complicated by liver cirrhosis and explore the effects of the spleen on immune function in this model." | 1.32 | Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis. ( Liu, QG; Ma, QY; Pan, CE; Yang, W; Yao, YM; Zhang, M, 2003) |
"Experimental observations were made on hepatic cancer induced with diethylnitrosamine (DEN) in guinea-pigs." | 1.26 | Immunological aspects of hepatocellular carcinoma in the guinea-pig. ( Desai, HN, 1976) |
"In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers." | 1.26 | Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice. ( McGuire, LJ; Poound, AW, 1978) |
"The frequency of hepatomata was almost equal in the aflatoxin and aflatoxin-carbon tetrachloride group." | 1.25 | Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. ( Lageron, A; Lemonnier, FJ; Scotto, JM; Stralin, HG, 1975) |
"One of 18 animals developed a hepatoma, but none of the mice given CCl4 in 0." | 1.25 | Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice. ( Inoue, S; Naito, Y; Takizawa, S; Watanabe, H, 1975) |
" The LD50 of DMN on the other hand was decreased for 3 days, after which it returned to normal." | 1.25 | Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine. ( Lawson, TA; Pound, AW, 1975) |
"3." | 1.25 | Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. ( Kwan, SW; Morris, HP; Webb, TE, 1968) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 67 (41.10) | 18.7374 |
1990's | 10 (6.13) | 18.2507 |
2000's | 14 (8.59) | 29.6817 |
2010's | 51 (31.29) | 24.3611 |
2020's | 21 (12.88) | 2.80 |
Authors | Studies |
---|---|
Humpton, TJ | 1 |
Hall, H | 1 |
Kiourtis, C | 1 |
Nixon, C | 1 |
Clark, W | 1 |
Hedley, A | 1 |
Shaw, R | 1 |
Bird, TG | 1 |
Blyth, K | 1 |
Vousden, KH | 1 |
Shaban, NZ | 1 |
Yehia, SA | 1 |
Awad, D | 1 |
Shaban, SY | 1 |
Saleh, SR | 1 |
Márquez-Quiroga, LV | 1 |
Arellanes-Robledo, J | 1 |
Vásquez-Garzón, VR | 1 |
Villa-Treviño, S | 1 |
Muriel, P | 1 |
Huang, YH | 1 |
Lian, WS | 1 |
Wang, FS | 1 |
Wang, PW | 1 |
Lin, HY | 1 |
Tsai, MC | 1 |
Yang, YL | 1 |
Song, Z | 2 |
Liu, X | 1 |
Zhang, W | 1 |
Luo, Y | 1 |
Xiao, H | 1 |
Liu, Y | 3 |
Dai, G | 1 |
Hong, J | 1 |
Li, A | 1 |
Li, J | 4 |
Xian, L | 1 |
Zheng, R | 2 |
Wang, Y | 6 |
Wan, X | 1 |
Wang, T | 2 |
Zhu, J | 1 |
Gao, L | 1 |
Wei, M | 1 |
Zhang, D | 1 |
Chen, L | 2 |
Wu, H | 1 |
Ma, J | 2 |
Li, L | 2 |
Zhang, N | 1 |
Xing, Q | 1 |
He, L | 1 |
Hong, F | 1 |
Qin, S | 1 |
Wu, B | 1 |
Feng, J | 1 |
Guo, J | 1 |
Wang, J | 2 |
Xiu, G | 1 |
Xu, J | 3 |
Ning, K | 1 |
Ling, B | 1 |
Fu, Q | 1 |
Cohen, SM | 1 |
Bevan, C | 1 |
Gollapudi, B | 1 |
Klaunig, JE | 1 |
Dekky, B | 1 |
Azar, F | 1 |
Bonnier, D | 1 |
Monseur, C | 1 |
Kalebić, C | 1 |
Arpigny, E | 1 |
Colige, A | 1 |
Legagneux, V | 1 |
Théret, N | 1 |
Wang, B | 1 |
Kaufmann, B | 1 |
Mogler, C | 1 |
Zhong, S | 1 |
Yin, Y | 1 |
Cheng, Z | 1 |
Schmid, RM | 1 |
Friess, H | 1 |
Hüser, N | 1 |
von Figura, G | 1 |
Hartmann, D | 1 |
Wang, Q | 1 |
Yang, Y | 4 |
Lei, C | 1 |
Yang, F | 2 |
Liang, L | 1 |
Chen, C | 2 |
Xia, J | 1 |
Wang, K | 2 |
Tang, N | 1 |
Kurahashi, T | 1 |
Yoshida, Y | 1 |
Ogura, S | 1 |
Egawa, M | 1 |
Furuta, K | 1 |
Hikita, H | 1 |
Kodama, T | 1 |
Sakamori, R | 1 |
Kiso, S | 1 |
Kamada, Y | 1 |
Wang, IC | 1 |
Eguchi, H | 1 |
Morii, E | 1 |
Doki, Y | 1 |
Mori, M | 1 |
Kalinichenko, VV | 1 |
Tatsumi, T | 1 |
Takehara, T | 1 |
Lu, ZN | 1 |
Luo, Q | 1 |
Zhao, LN | 1 |
Shi, Y | 1 |
Wang, N | 1 |
Wang, L | 4 |
Han, ZG | 1 |
She, S | 1 |
Wu, X | 1 |
Zheng, D | 1 |
Pei, X | 1 |
Sun, Y | 2 |
Zhou, J | 1 |
Nong, L | 1 |
Guo, C | 1 |
Lv, P | 1 |
Song, Q | 1 |
Zheng, C | 1 |
Liang, W | 1 |
Huang, S | 1 |
Li, Q | 1 |
Liu, Z | 2 |
Li, Y | 2 |
Zhang, Y | 3 |
Kong, W | 1 |
You, H | 1 |
Xi, J | 1 |
Campos, G | 1 |
Schmidt-Heck, W | 1 |
De Smedt, J | 1 |
Widera, A | 1 |
Ghallab, A | 1 |
Pütter, L | 1 |
González, D | 1 |
Edlund, K | 1 |
Cadenas, C | 1 |
Marchan, R | 1 |
Guthke, R | 1 |
Verfaillie, C | 1 |
Hetz, C | 1 |
Sachinidis, A | 1 |
Braeuning, A | 1 |
Schwarz, M | 1 |
Weiß, TS | 1 |
Banhart, BK | 1 |
Hoek, J | 1 |
Vadigepalli, R | 1 |
Willy, J | 1 |
Stevens, JL | 1 |
Hay, DC | 1 |
Hengstler, JG | 1 |
Godoy, P | 1 |
Lin, YH | 1 |
Zhang, S | 2 |
Zhu, M | 1 |
Lu, T | 1 |
Chen, K | 1 |
Wen, Z | 1 |
Wang, S | 2 |
Xiao, G | 1 |
Luo, D | 1 |
Jia, Y | 1 |
MacConmara, M | 1 |
Hoshida, Y | 3 |
Singal, AG | 1 |
Yopp, A | 1 |
Zhu, H | 1 |
Jung, YS | 1 |
Stratton, SA | 1 |
Lee, SH | 1 |
Kim, MJ | 1 |
Jun, S | 1 |
Zhang, J | 1 |
Zheng, B | 1 |
Cervantes, CL | 1 |
Cha, JH | 1 |
Barton, MC | 1 |
Park, JI | 1 |
Kikuchi, A | 1 |
Singh, S | 2 |
Poddar, M | 2 |
Nakao, T | 1 |
Schmidt, HM | 1 |
Gayden, JD | 1 |
Sato, T | 1 |
Arteel, GE | 1 |
Monga, SP | 2 |
Ni, M | 1 |
Yu, H | 1 |
Wen, X | 1 |
Liu, G | 1 |
Hu, Y | 2 |
Li, Z | 2 |
Wang, SS | 1 |
Tang, XT | 1 |
Lin, M | 1 |
Yuan, J | 1 |
Peng, YJ | 1 |
Yin, X | 1 |
Shang, G | 1 |
Ge, G | 1 |
Ren, Z | 1 |
Zhou, BO | 1 |
Sun, M | 1 |
Li, W | 2 |
Liu, C | 2 |
Jiang, Z | 1 |
Gu, P | 1 |
Wang, W | 1 |
You, R | 1 |
Ba, Q | 1 |
Li, X | 3 |
Wang, H | 4 |
Sydor, S | 1 |
Manka, P | 1 |
Best, J | 1 |
Jafoui, S | 1 |
Sowa, JP | 1 |
Zoubek, ME | 1 |
Hernandez-Gea, V | 1 |
Cubero, FJ | 1 |
Kälsch, J | 1 |
Vetter, D | 1 |
Fiel, MI | 1 |
Bian, CB | 1 |
Nelson, LJ | 1 |
Moshage, H | 1 |
Faber, KN | 1 |
Paul, A | 1 |
Baba, HA | 1 |
Gerken, G | 1 |
Friedman, SL | 1 |
Canbay, A | 1 |
Bechmann, LP | 1 |
Ali, MM | 1 |
H Borai, I | 1 |
Ghanem, HM | 1 |
H Abdel-Halim, A | 1 |
Mousa, FM | 1 |
Wu, Q | 1 |
Chen, JX | 1 |
Chen, Y | 5 |
Cai, LL | 1 |
Wang, XZ | 1 |
Guo, WH | 1 |
Zheng, JF | 1 |
Dou, C | 1 |
Tu, K | 1 |
Zhang, H | 3 |
Yaqoob, U | 1 |
Wen, J | 1 |
van Deursen, J | 1 |
Sicard, D | 1 |
Tschumperlin, D | 1 |
Zou, H | 1 |
Huang, WC | 1 |
Urrutia, R | 1 |
Shah, VH | 1 |
Kang, N | 1 |
Preziosi, M | 1 |
Delire, B | 1 |
Henriet, P | 1 |
Lemoine, P | 1 |
Leclercq, IA | 1 |
Stärkel, P | 1 |
D'Souza, AM | 1 |
Jiang, Y | 1 |
Cast, A | 1 |
Valanejad, L | 1 |
Wright, M | 1 |
Lewis, K | 1 |
Kumbaji, M | 1 |
Shah, S | 1 |
Smithrud, D | 1 |
Karns, R | 1 |
Shin, S | 1 |
Timchenko, N | 1 |
Lee, C | 1 |
Kim, M | 1 |
Lee, JH | 1 |
Oh, J | 1 |
Shin, HH | 1 |
Lee, SM | 1 |
Scherer, PE | 1 |
Kwon, HM | 1 |
Choi, JH | 1 |
Park, J | 1 |
Ito, Y | 1 |
Nakajima, K | 1 |
Masubuchi, Y | 1 |
Kikuchi, S | 1 |
Saito, F | 1 |
Akahori, Y | 1 |
Jin, M | 1 |
Yoshida, T | 1 |
Shibutani, M | 1 |
Manco, R | 1 |
Clerbaux, LA | 1 |
Verhulst, S | 1 |
Bou Nader, M | 1 |
Sempoux, C | 1 |
Ambroise, J | 1 |
Bearzatto, B | 1 |
Gala, JL | 1 |
Horsmans, Y | 1 |
van Grunsven, L | 1 |
Desdouets, C | 1 |
Leclercq, I | 1 |
Zuo, L | 1 |
Zhu, Y | 1 |
Hu, L | 2 |
Pan, X | 1 |
Li, K | 1 |
Du, N | 1 |
Huang, Y | 2 |
Zhang, HE | 1 |
Henderson, JM | 1 |
Gorrell, MD | 1 |
Hu, M | 1 |
Xu, L | 2 |
An, S | 1 |
Tang, Y | 2 |
Zhou, X | 2 |
Liu, R | 1 |
Huang, L | 1 |
Seo, W | 1 |
Gao, Y | 1 |
He, Y | 1 |
Sun, J | 1 |
Xu, H | 1 |
Feng, D | 1 |
Park, SH | 1 |
Cho, YE | 1 |
Guillot, A | 1 |
Ren, T | 1 |
Wu, R | 1 |
Kim, SJ | 1 |
Hwang, S | 1 |
Liangpunsakul, S | 1 |
Niu, J | 2 |
Gao, B | 2 |
Papp, V | 1 |
Rókusz, A | 1 |
Dezső, K | 1 |
Bugyik, E | 1 |
Szabó, V | 1 |
Pávai, Z | 1 |
Paku, S | 1 |
Nagy, P | 1 |
Sengupta, D | 1 |
Chowdhury, KD | 1 |
Sarkar, A | 1 |
Paul, S | 1 |
Sadhukhan, GC | 1 |
Luo, M | 1 |
Huang, SX | 1 |
Kuang, ZP | 1 |
Luo, XL | 1 |
Li, YD | 1 |
Wu, JN | 1 |
Xie, YA | 1 |
Xu, B | 1 |
Li, SH | 1 |
Gao, SB | 1 |
Ding, LH | 1 |
Yin, ZY | 1 |
Lin, X | 1 |
Feng, ZJ | 1 |
Wang, XM | 1 |
Jin, GH | 1 |
Chappell, G | 1 |
Kutanzi, K | 1 |
Uehara, T | 1 |
Tryndyak, V | 1 |
Hong, HH | 1 |
Hoenerhoff, M | 1 |
Beland, FA | 1 |
Rusyn, I | 1 |
Pogribny, IP | 1 |
Reiberger, T | 2 |
Duyverman, AM | 1 |
Huang, P | 2 |
Samuel, R | 2 |
Hiddingh, L | 1 |
Roberge, S | 2 |
Koppel, C | 1 |
Lauwers, GY | 3 |
Zhu, AX | 2 |
Jain, RK | 2 |
Duda, DG | 2 |
Zhang, C | 1 |
Wei, Q | 1 |
Jiang, T | 1 |
Shou, X | 1 |
Li, ZQ | 1 |
Wen, H | 1 |
Fuchs, BC | 1 |
Fujii, T | 1 |
Wei, L | 1 |
Yamada, S | 1 |
McGinn, CM | 1 |
DePeralta, DK | 1 |
Chen, X | 1 |
Kuroda, T | 1 |
Lanuti, M | 1 |
Schmitt, AD | 1 |
Gupta, S | 1 |
Crenshaw, A | 1 |
Onofrio, R | 1 |
Taylor, B | 1 |
Winckler, W | 1 |
Bardeesy, N | 2 |
Caravan, P | 1 |
Golub, TR | 1 |
Tanabe, KK | 1 |
Li, F | 2 |
Ma, N | 1 |
Zhao, R | 1 |
Wu, G | 1 |
Qiao, Y | 1 |
Han, D | 1 |
Xu, Y | 1 |
Xiang, Y | 1 |
Yan, B | 1 |
Jin, J | 1 |
Lv, G | 1 |
Xu, C | 1 |
Gao, X | 1 |
Luo, S | 1 |
Abdel-Monem, AR | 1 |
Kandil, ZA | 1 |
Abdel-Naim, AB | 1 |
Abdel-Sattar, E | 1 |
Caviglia, JM | 1 |
Schwabe, RF | 1 |
Wree, A | 1 |
Johnson, CD | 1 |
Font-Burgada, J | 1 |
Eguchi, A | 1 |
Povero, D | 1 |
Karin, M | 1 |
Feldstein, AE | 1 |
Sur, S | 1 |
Pal, D | 1 |
Banerjee, K | 1 |
Mandal, S | 1 |
Das, A | 1 |
Roy, A | 1 |
Panda, CK | 1 |
Hung, TM | 1 |
Yuan, RH | 1 |
Huang, WP | 1 |
Chen, YH | 1 |
Lin, YC | 1 |
Lin, CW | 1 |
Lai, HS | 1 |
Lee, PH | 1 |
Ramjiawan, RR | 1 |
Hato, T | 1 |
Fan, C | 1 |
Yang, J | 1 |
Qiu, B | 1 |
Liu, W | 1 |
Xiao, J | 1 |
Xu, M | 1 |
Hu, C | 1 |
Xu, X | 1 |
Lu, Y | 1 |
Xue, S | 1 |
Nie, L | 1 |
Ji, F | 1 |
Hui, L | 1 |
Tao, W | 1 |
Wei, B | 1 |
Xue, F | 2 |
Ge, R | 1 |
Yang, L | 2 |
Liu, K | 1 |
Chung, SI | 1 |
Moon, H | 1 |
Kim, DY | 2 |
Cho, KJ | 1 |
Ju, HL | 1 |
Ahn, SH | 1 |
Han, KH | 1 |
Ro, SW | 1 |
Moles, A | 1 |
Butterworth, JA | 1 |
Sanchez, A | 1 |
Hunter, JE | 1 |
Leslie, J | 1 |
Sellier, H | 1 |
Tiniakos, D | 1 |
Cockell, SJ | 1 |
Mann, DA | 1 |
Oakley, F | 1 |
Perkins, ND | 1 |
Liu, CH | 1 |
Chan, KM | 1 |
Chiang, T | 1 |
Liu, JY | 1 |
Chern, GG | 1 |
Hsu, FF | 1 |
Wu, YH | 1 |
Liu, YC | 1 |
Tsuji, S | 1 |
Ohbayashi, T | 1 |
Yamakage, K | 1 |
Oshimura, M | 1 |
Tada, M | 1 |
Magdaleno, F | 1 |
Arriazu, E | 1 |
Ruiz de Galarreta, M | 1 |
Ge, X | 1 |
Conde de la Rosa, L | 1 |
Nieto, N | 1 |
Hanna, D | 1 |
Riedmaier, AE | 1 |
Sugamori, KS | 1 |
Grant, DM | 1 |
Polat, B | 1 |
Halici, Z | 1 |
Cadirci, E | 1 |
Karakus, E | 1 |
Bayir, Y | 1 |
Albayrak, A | 1 |
Unal, D | 1 |
Matsuura, K | 1 |
Sawai, H | 1 |
Ikeo, K | 1 |
Ogawa, S | 1 |
Iio, E | 1 |
Isogawa, M | 1 |
Shimada, N | 1 |
Komori, A | 1 |
Toyoda, H | 1 |
Kumada, T | 1 |
Namisaki, T | 1 |
Yoshiji, H | 2 |
Sakamoto, N | 1 |
Nakagawa, M | 1 |
Asahina, Y | 1 |
Kurosaki, M | 1 |
Izumi, N | 1 |
Enomoto, N | 1 |
Kusakabe, A | 1 |
Kajiwara, E | 1 |
Itoh, Y | 1 |
Ide, T | 1 |
Tamori, A | 1 |
Matsubara, M | 1 |
Kawada, N | 1 |
Shirabe, K | 1 |
Tomita, E | 1 |
Honda, M | 1 |
Kaneko, S | 1 |
Nishina, S | 1 |
Suetsugu, A | 1 |
Hiasa, Y | 1 |
Watanabe, H | 2 |
Genda, T | 1 |
Sakaida, I | 1 |
Nishiguchi, S | 1 |
Takaguchi, K | 1 |
Tanaka, E | 1 |
Sugihara, J | 1 |
Shimada, M | 1 |
Kondo, Y | 1 |
Kawai, Y | 1 |
Kojima, K | 1 |
Nagasaki, M | 1 |
Tokunaga, K | 1 |
Tanaka, Y | 1 |
Takahara, T | 1 |
Mazzone, M | 1 |
Yata, Y | 1 |
Nonome, K | 1 |
Kanayama, M | 1 |
Kawai, K | 1 |
Pisacane, AM | 1 |
Takahara, S | 1 |
Li, XK | 1 |
Comoglio, PM | 1 |
Sugiyama, T | 1 |
Michieli, P | 1 |
Hosui, A | 2 |
Kimura, A | 1 |
Yamaji, D | 1 |
Zhu, BM | 3 |
Na, R | 1 |
Hennighausen, L | 3 |
Ma, X | 1 |
Chen, H | 1 |
Ning, G | 1 |
Sakai, T | 1 |
Liu, L | 1 |
Teng, X | 1 |
Ishimaru, N | 1 |
Mukai-Sakai, R | 1 |
Tran, NH | 1 |
Kim, SM | 1 |
Sano, N | 1 |
Hayashi, Y | 1 |
Kaji, R | 1 |
Fukui, K | 1 |
Hackl, C | 1 |
Mori, A | 1 |
Moser, C | 1 |
Lang, SA | 1 |
Dayoub, R | 1 |
Weiss, TS | 1 |
Schlitt, HJ | 1 |
Geissler, EK | 1 |
Hellerbrand, C | 1 |
Stoeltzing, O | 1 |
Rivadeneira, DB | 1 |
Mayhew, CN | 1 |
Thangavel, C | 1 |
Sotillo, E | 1 |
Reed, CA | 1 |
Graña, X | 1 |
Knudsen, ES | 1 |
Luke, NS | 1 |
Sams, R | 1 |
DeVito, MJ | 1 |
Conolly, RB | 1 |
El-Masri, HA | 1 |
Mathan, G | 1 |
Fatima, G | 1 |
Saxena, AK | 1 |
Chandan, BK | 1 |
Jaggi, BS | 1 |
Gupta, BD | 1 |
Qazi, GN | 1 |
Balasundaram, C | 1 |
Anand Rajan, KD | 1 |
Kumar, VL | 1 |
Kumar, V | 1 |
ESCHENBRENNER, AB | 1 |
MILLER, E | 1 |
Yu, JH | 2 |
Wickre, M | 1 |
Riedlinger, G | 2 |
Chen, W | 1 |
Robinson, GW | 1 |
Lafdil, F | 1 |
Park, O | 1 |
Yin, S | 1 |
Miller, AM | 1 |
Sun, Z | 1 |
Komatsu, Y | 1 |
Waku, T | 1 |
Iwasaki, N | 1 |
Ono, W | 1 |
Yamaguchi, C | 1 |
Yanagisawa, J | 1 |
Kang, K | 1 |
Hussain, T | 1 |
Siddiqui, HH | 1 |
Fareed, S | 1 |
Vijayakumar, M | 1 |
Rao, CV | 1 |
Chaung, SS | 1 |
Lin, CC | 1 |
Lin, J | 1 |
Yu, KH | 1 |
Hsu, YF | 1 |
Yen, MH | 1 |
ANDERVONT, HB | 1 |
LEDUC, EH | 1 |
WILSON, JW | 1 |
MALTONI, C | 3 |
PRODI, G | 1 |
DELLA PORTA, G | 1 |
TERRACINI, B | 1 |
SHUBIK, P | 1 |
COLE, LJ | 2 |
NOWELL, PC | 2 |
KIPLINGER, GF | 1 |
KENSLER, CJ | 1 |
SALYAMON, L | 1 |
SIMLER, M | 1 |
MAURER, M | 1 |
MANDARD, JC | 1 |
Yao, YM | 1 |
Liu, QG | 1 |
Yang, W | 1 |
Zhang, M | 1 |
Ma, QY | 1 |
Pan, CE | 1 |
RUDALI, G | 1 |
MARIANI, PL | 1 |
STOWELL, RE | 1 |
LEE, CS | 1 |
TSUBOI, KK | 1 |
VILLASANA, A | 1 |
Sun, HL | 1 |
Du, HJ | 1 |
An, W | 1 |
Kato, I | 1 |
Kawaguchi, H | 1 |
Takasawa, K | 1 |
Hibino, Y | 1 |
Hiraga, K | 1 |
Tanimoto, A | 1 |
Kuribayashi, S | 1 |
Huang, X | 1 |
Yu, C | 1 |
Jin, C | 1 |
Yang, C | 1 |
Xie, R | 1 |
Cao, D | 1 |
Wang, F | 1 |
McKeehan, WL | 1 |
Xu, Q | 1 |
Shen, YP | 1 |
Xu, AL | 1 |
Nagano, K | 1 |
Sasaki, T | 1 |
Umeda, Y | 1 |
Nishizawa, T | 1 |
Ikawa, N | 1 |
Ohbayashi, H | 1 |
Arito, H | 1 |
Yamamoto, S | 1 |
Fukushima, S | 1 |
Seki, T | 1 |
Morimura, S | 1 |
Tabata, S | 1 |
Shigematsu, T | 1 |
Kida, K | 1 |
Sakata, T | 1 |
Watanabe, A | 1 |
Takei, N | 1 |
Shiota, T | 1 |
Nakatsukasa, H | 1 |
Fujiwara, M | 1 |
Kobayashi, M | 1 |
Nagashima, H | 1 |
Hasegawa, R | 2 |
Tatematsu, M | 4 |
Tsuda, H | 1 |
Shirai, T | 1 |
Hagiwara, A | 1 |
Ito, N | 2 |
Habs, H | 1 |
Künstler, K | 1 |
Schmähl, D | 1 |
Tomatis, L | 1 |
Ghoshal, AK | 1 |
Mullen, B | 1 |
Medline, A | 1 |
Farber, E | 3 |
Faktor, VM | 1 |
Poltoranina, VS | 1 |
Uryvaeva, IV | 1 |
Imaida, K | 1 |
Murasaki, G | 1 |
Fukuda, K | 1 |
Kojiro, M | 1 |
Chiu, JF | 1 |
Tsunematsu, S | 1 |
Ishii, H | 1 |
Frezza, EE | 1 |
Gerunda, GE | 1 |
Farinati, F | 1 |
DeMaria, N | 1 |
Galligioni, A | 1 |
Plebani, F | 1 |
Giacomin, A | 1 |
Van Thiel, DH | 1 |
Yang, SM | 1 |
Salminen, WF | 1 |
Voellmy, R | 1 |
Roberts, SM | 1 |
Nakae, D | 2 |
Kobayashi, Y | 1 |
Akai, H | 1 |
Andoh, N | 1 |
Satoh, H | 1 |
Ohashi, K | 1 |
Tsutsumi, M | 2 |
Konishi, Y | 2 |
Kobayashi, K | 1 |
Mutai, M | 1 |
Goto, K | 1 |
Inada, K | 2 |
Tsukamoto, T | 2 |
Nakanishi, H | 2 |
Lynge, E | 1 |
Anttila, A | 1 |
Hemminki, K | 1 |
Sakai, H | 1 |
Yamamoto, M | 1 |
Yanai, T | 1 |
Masegi, T | 1 |
Yoda-Murakami, M | 1 |
Taniguchi, M | 1 |
Takahashi, K | 1 |
Kawamata, S | 1 |
Saito, K | 1 |
Choi-Miura, NH | 1 |
Tomita, M | 1 |
Sabine, JR | 1 |
Desai, HN | 1 |
Scotto, JM | 1 |
Stralin, HG | 1 |
Lageron, A | 1 |
Lemonnier, FJ | 1 |
Takizawa, S | 1 |
Naito, Y | 1 |
Inoue, S | 1 |
Kozuka, S | 1 |
Sassa, R | 1 |
Saliamon, LS | 2 |
Ostretsova, IB | 3 |
Senatorova, TA | 1 |
Mori, H | 1 |
Ushimaru, Y | 1 |
Tanaka, T | 1 |
Hirono, I | 1 |
Pound, AW | 3 |
Poound, AW | 1 |
McGuire, LJ | 1 |
Voronova, LA | 1 |
Ivanov, SD | 1 |
Kanematsu, T | 1 |
Letnansky, K | 1 |
Wenzel, J | 1 |
Parker, S | 1 |
Gruenstein, M | 1 |
Lawson, TA | 2 |
Maruyama, H | 1 |
Amanuma, T | 1 |
Takashima, Y | 1 |
Tsujiuchi, T | 1 |
Denda, A | 1 |
Columbano, A | 2 |
Ledda-Columbano, GM | 2 |
Ennas, MG | 1 |
Curto, M | 1 |
Chelo, A | 1 |
Pani, P | 2 |
Büsser, MT | 1 |
Lutz, WK | 1 |
Castro, GD | 1 |
Díaz Gómez, MI | 1 |
Castro, JA | 1 |
Harris, L | 1 |
Morris, LE | 1 |
Slater, TF | 2 |
Cheeseman, KH | 1 |
Ingold, KU | 1 |
Katsukura, Y | 1 |
Abe, N | 1 |
Watabe, N | 1 |
Tsuchiya, T | 1 |
Oruambo, IF | 1 |
Van Duuren, BL | 1 |
Préat, V | 1 |
Lans, M | 2 |
de Gerlache, J | 2 |
Taper, H | 1 |
Roberfroid, M | 1 |
Coni, P | 1 |
Deleener, A | 1 |
Kirsch-Volders, M | 1 |
Pascal, SG | 1 |
Saulenas, AM | 1 |
Fournier, GA | 1 |
Seddon, JM | 1 |
Hatfield, RM | 1 |
Albert, DM | 1 |
Kroes, R | 1 |
Williams, GM | 1 |
Weisburger, JH | 1 |
Idéo, G | 1 |
Morganti, A | 1 |
Dioguardi, N | 1 |
Webb, TE | 2 |
Potter, VR | 1 |
Stanislawski-Birencwajg, M | 1 |
Uriel, J | 1 |
Grabar, P | 1 |
Kwan, SW | 1 |
Morris, HP | 1 |
Peretti, S | 2 |
Ghetti, G | 2 |
Ashmarin, IP | 1 |
Lyzlova, SN | 1 |
Pluzhnikova, GF | 1 |
Vas'kina, LV | 1 |
Warwick, GP | 1 |
Reuber, MD | 1 |
Sun, SC | 1 |
Wei, RD | 1 |
Schaeffer, BT | 1 |
Horn, L | 1 |
Hathway, DE | 1 |
Kittlick, PD | 1 |
Büttner, H | 1 |
Klemm, W | 1 |
Ueda, Y | 3 |
Curtis, HJ | 2 |
Tilley, J | 2 |
Mirvish, SS | 1 |
Sidransky, H | 1 |
Kawasaki, H | 1 |
Czernik, C | 1 |
Burke, WT | 1 |
Gangloff, EC | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma[NCT01356628] | Phase 2 | 23 participants (Actual) | Interventional | 2011-05-25 | Active, not recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The number and nature of adverse events as a measure of safety and tolerability. Safety analysis will be conducted on all patients who receive at least one dose of PD-0332991 during the study period or follow-up. An adverse event is any unfavorable and unintended sign, symptom, syndrome or illness that develops during the period of observation in the clinical study, including a new illness or condition, worsening of a concomitant illnesses or condition, effect of the study medication or combination of 2 or more factors. (NCT01356628)
Timeframe: From date of randomization through study completion, assessed up to 100 months
Intervention | Adverse Events (Number) |
---|---|
PD-0332991 | 504 |
Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST Version 1.1), as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). The appearance of one or more new lesions is also considered progression. (NCT01356628)
Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
Intervention | months (Mean) |
---|---|
PD-0332991 | 8 |
7 reviews available for carbon tetrachloride and Liver Neoplasms
Article | Year |
---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Evaluation of the carcinogenicity of carbon tetrachloride.
Topics: Adrenal Gland Neoplasms; Animals; Carbon Tetrachloride; Humans; Lipids; Liver Neoplasms; Mice; Pheoc | 2023 |
[Etiological mechanism of toxic hepatitis].
Topics: Alcohol Drinking; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug-Relate | 1995 |
Organic solvents and cancer.
Topics: Alcohol Drinking; Benzene; Biliary Tract Neoplasms; Carbon Tetrachloride; Carcinogens; China; Cohort | 1997 |
Carbon tetrachloride.
Topics: Air Pollutants; Animals; Carbon Tetrachloride; Carcinogens; Embryo, Mammalian; Embryo, Nonmammalian; | 1979 |
Free radicals and tissue injury: fact and fiction.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fr | 1987 |
Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals.
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemica | 1974 |
156 other studies available for carbon tetrachloride and Liver Neoplasms
Article | Year |
---|---|
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Liver Regeneration | 2022 |
A Titanium (IV)-Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical | 2021 |
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of
Topics: 3' Untranslated Regions; Angiopoietin-2; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2022 |
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fibrosis; Hepatic Stellate Cells; Humans; | 2022 |
Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro.
Topics: Aged; Aging; Animals; Canthaxanthin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Humans; Hydrog | 2022 |
Identification of circular RNA biomarkers for Pien Tze Huang treatment of CCl4‑induced liver fibrosis using RNA‑sequencing.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Case-Control Studies; Drugs, C | 2022 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
ADAMTS12 is a stromal modulator in chronic liver disease.
Topics: ADAMTS Proteins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatic Stellate Cells; Humans; Li | 2023 |
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis; | 2023 |
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet | 2019 |
Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cells, Cultured; Chemokine CCL2; Disease M | 2020 |
The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.
Topics: Animals; Aristolochic Acids; Bile Duct Neoplasms; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2020 |
PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Polarity; C | 2020 |
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury, Ch | 2020 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carbon Tetrachloride; Carcinogenesis; Car | 2021 |
Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Movement; Hepatic Stellate Cells; Liv | 2020 |
Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Neoplasms; Prospective Studies; Rats; Rats, Wi | 2021 |
Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Cancer-Associated Fibroblasts; Ca | 2021 |
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Drugs, Chinese Herbal; Hepatic | 2021 |
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellula | 2017 |
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; | 2018 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
Topics: Animals; Benzoates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transdiffere | 2018 |
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer.
Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamin | 2018 |
Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Male; Mice; Mice, | 2018 |
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Topics: Animals; Benzenesulfonates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens.
Topics: Animals; Cadherins; Carbon Tetrachloride; Cell Proliferation; Cell Transformation, Neoplastic; Dieth | 2019 |
Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Chemical and Dr | 2019 |
PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation.
Topics: Acid Sensing Ion Channels; Animals; Calcium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Caspas | 2019 |
Animal models for hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Disease Models, Animal; Gene Editing; Huma | 2019 |
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy.
Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Cell Line, Tumor; Disease Progression; Female; Gene Tr | 2019 |
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Topics: Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carbon Tetrachl | 2019 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon T | 2014 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; CD11b Antigen; Cell Line, Tumor; Cell Move | 2014 |
Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Live | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Coculture Techniques; Hep | 2014 |
A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl₄-induced injury on human hepatoma cell line (Huh7).
Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Fruit; Humans; Liver Neoplasms; M | 2015 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Amarogentin regulates self renewal pathways to restrict liver carcinogenesis in experimental mouse model.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation | 2016 |
Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis.
Topics: Adult; Aged; Autophagy; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Humans; | 2015 |
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Neoplasms; Liver Ne | 2015 |
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatoc | 2015 |
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia | 2015 |
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; | 2016 |
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.
Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; Ge | 2016 |
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Gene Knock-In Techniques; Hepatocytes; | 2016 |
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyc | 2016 |
A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Biological Assay; Carbon Tetrachl | 2016 |
Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cartilage Oligomeric Matrix Protein; Hepat | 2016 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Fibrosis; Humans; Inflammation; | 2017 |
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H | 2017 |
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells | 2008 |
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Topics: Animals; Carbon Tetrachloride; Disease Progression; Fibrinogens, Abnormal; Gene Deletion; Haptoglobi | 2009 |
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati | 2009 |
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; | 2010 |
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2010 |
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell | 2010 |
Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Proliferation; Cell Survival; Chemical | 2010 |
Chemoprevention with aqueous extract of Butea monosperma flowers results in normalization of nuclear morphometry and inhibition of a proliferation marker in liver tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Butea; Carbon Tetrachloride; Cell Nucleus; Cell Prolifer | 2011 |
Liver necrosis and the induction of carbon tetrachloride hepatomas in strain A mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Diseases; Liver Neoplasms; Mi | 1946 |
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cyclin-Dependen | 2010 |
Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis.
Topics: Animals; Carbon Tetrachloride; DNA Damage; Fibrosis; Gene Deletion; Gene Expression Regulation, Neop | 2011 |
Global analysis of DNA methylation in early-stage liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chromosomes, Mammalian; Computational Biol | 2012 |
The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbon Tetrachloride; Carc | 2012 |
Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats.
Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Carbon Tetrachloride; Carcinoembryonic Antigen | 2012 |
The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Ch | 2003 |
Induction of hepatomas in strain C3H mice with 4-o-tolyazoo-toluidine and carbon tetrachloride.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Coloring A | 1958 |
Transplantation of carbon tetrachloride-induced hepatomas in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Neoplasms, Experime | 1959 |
Effect of cirrhogenic treatment with carbon tetrachloride on the development of liver neoplasia in rats fed with butter-yellow (p-dimethylaminoazobenzene).
Topics: Animals; Butter; Carbon Tetrachloride; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; | 1959 |
Induction with carbon tetrachloride of liver-cell carcinomas in hamsters.
Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental | 1961 |
Accelerated induction of hepatomas in fast neutron irradiated mice injected with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular; Fast Neutr | 1962 |
Failure of phenoxybenzamine to prevent formation of hepatomas after chronic carbon tetrachloride administration.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular; Liver Neoplasms; Ph | 1963 |
INFLAMMATORY REACTIVITY AND CARCINOGENESIS.
Topics: Aniline Compounds; Animals; Azo Compounds; Carbon Tetrachloride; Carcinogenesis; Carcinogens; Fluore | 1963 |
ACCELERATED INDUCTION OF HEPATOMAS IN FAST NEUTRON-IRRADIATED MICE INJECTED WITH CARBON TETRACHLORIDE.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fast Neutrons; Gastrointestinal Neoplasms; | 1964 |
[CANCER OF LIVER ON CIRRHOSIS DUE TO CARBON TETRACHLORIDE].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; Liver Neoplasms; Toxicology | 1964 |
Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma 256, Walker; Disease Models, Animal; Killer Cells, Natural; | 2003 |
[The production of liver tumors by carbon tetrachloride in mice of XVII ivry strain].
Topics: Animals; Carbon Tetrachloride; Liver; Liver Neoplasms; Mice | 1950 |
Histochemical and microchemical changes in experimental cirrhosis and hepatoma formation in mice by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Cirrhosis, Experime | 1951 |
[Transfection of human hepatic stimulator substance gene could protect BEL-7402 cells against hepatotoxins].
Topics: Apoptosis; Carbon Tetrachloride; Cytoprotection; Free Radicals; Growth Substances; Humans; Hydrogen | 2004 |
The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4.
Topics: Animals; Base Sequence; Binding Sites; Carbon Tetrachloride; Carcinoma, Hepatocellular; Carrier Prot | 2006 |
Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver.
Topics: Animals; Carbon Tetrachloride; Contrast Media; Dextrans; Edetic Acid; Female; Ferrosoferric Oxide; H | 2005 |
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Fibroblas | 2006 |
[Cystic degeneration in liver injury induced by CCl4 in SD rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cysts; Disease Models, Animal | 2006 |
Inhalation carcinogenicity and chronic toxicity of carbon tetrachloride in rats and mice.
Topics: Administration, Inhalation; Animals; Carbon Tetrachloride; Humans; Inhalation Exposure; Liver Neopla | 2007 |
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu.
Topics: Acetic Acid; Alcoholic Beverages; Animals; Antioxidants; Carbon Tetrachloride; Carcinoma, Hepatocell | 2008 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Combined effects of fast-neutron irradiation and subcutaneously applied carbon tetrachloride or chloroform in C57Bl6 mice.
Topics: Animals; Carbon Tetrachloride; Chloroform; Dose-Response Relationship, Drug; Dose-Response Relations | 1983 |
Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Liver; Liver Neoplasms; Liver R | 1983 |
[Changes in the nature of the hepatocyte proliferation in the liver and adenomatous nodes of mice in CC14-induced carcinogenesis].
Topics: Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; DNA, Neoplasm; Liver; Liver Neoplasm | 1982 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Ischemia; Keratins; Liver; Liver Circulation; Liver Ne | 1993 |
CCL4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Copper; Disease Models, Animal; Estradiol; | 1994 |
[Establishment of a model of human gastric cancer with liver metastasis in nude mice].
Topics: Adenocarcinoma, Mucinous; Animals; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Neopl | 1993 |
Induction of hsp 70 in HepG2 cells in response to hepatotoxicants.
Topics: Bromobenzenes; Cadmium; Carbon Tetrachloride; Carcinogens; Cells, Cultured; Chromatography, Gas; Coc | 1996 |
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response | 1997 |
Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).
Topics: Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division; | 1997 |
Summation of initiation activities of low doses of the non-hepatocarcinogen 1,2-dimethylhydrazine in the liver after carbon tetrachloride administration.
Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; Cell Division; | 2000 |
Change in expression of GBP28/adiponectin in carbon tetrachloride-administrated mouse liver.
Topics: Adiponectin; Animals; Antisense Elements (Genetics); Carbon Tetrachloride; Carcinoma, Hepatocellular | 2001 |
Metabolic controls in precancerous liver-VII. Time course of loss of dietary feedback control of cholesterol synthesis during carcinogen treatment.
Topics: Animals; Carbon Tetrachloride; Cholesterol; Cholesterol, Dietary; Cyclohexanes; Ethionine; Feedback; | 1976 |
Immunological aspects of hepatocellular carcinoma in the guinea-pig.
Topics: Animals; Antigens, Neoplasm; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Migration Inhibit | 1976 |
Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular | 1975 |
Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism; | 1975 |
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes; | 1976 |
[Several patterns in the disdifferentiated changes in the activity of enzymes during blastomogenesis].
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Neoplasms, Experime | 1977 |
Effect of carbon tetrachloride on carcinogenicity of petasites japonicus and transplantability of induced tumors.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Liver Neoplasms; Male; Neoplasm | 1977 |
Influence of carbon tetrachloride on induction of tumours of the liver and kidneys in mice by netrosamines.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Kidney; Kidney Neoplasms; Lethal Dose 50; Liver; Live | 1978 |
Influence of repeated liver regeneration on hepatic carcinogenesis by diethylnitrosamine in mice.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Liver Regenera | 1978 |
[Hepatic RNA resistance to enzymatic degradation in the process of hepatocarcinogenesis in rats].
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experime | 1978 |
Promoting effect of carbon tetrachloride on azo-dye hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Female; Liver Neoplasms; Methyldimethylaminoazobenzene; p-Dimethylami | 1976 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic; | 1976 |
Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Hepatectomy; Kidney Neoplasms; Lethal Dose 50; L | 1975 |
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu | 1992 |
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosa | 1990 |
Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters.
Topics: Adipates; Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzidines; Biological Availability; Carbon Tet | 1987 |
Species differences in the interaction between CCl4 reactive metabolites and liver DNA or nuclear protein fractions.
Topics: Animals; Carbon Tetrachloride; Cricetinae; DNA; Liver; Liver Neoplasms; Mesocricetus; Mice; Mice, In | 1989 |
Protective value of a liver initiation-promotion regimen against the lethal effect of carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Neoplasms; Male; Rats; Rats, Inbred F344 | 1989 |
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Che | 1985 |
Distribution pattern of liver matrix proteins, fibronectin and type I collagen, in DAB-induced hepatoma of rat.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Collagen; Female; Fibronectins; Histocytoc | 1985 |
Distribution of carbon tetrachloride-metabolite(s) to DNase I-sensitive and -resistant chromatin.
Topics: Biotransformation; Carbon Tetrachloride; Chromatin; Deoxyribonuclease I; DNA Damage; Gene Expression | 1987 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv | 1987 |
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms | 1987 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
An investigation into the association between liver damage and metastatic uveal melanoma.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cricetinae; Liver Diseases; L | 1985 |
Early appearance of serum -fetoprotein as a function of dosage of various hepatocarcinogens.
Topics: Acetamides; Administration, Oral; Aflatoxins; Alpha-Globulins; Animals; Antilymphocyte Serum; Carbon | 1973 |
Gamma-glutamyl transpeptidase: a clinical and experimental study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon | 1972 |
Polyribosomes in rat tissues. IV. On the abnormal dimer peak in hepatomas.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin; In Vitro Te | 1966 |
Association of embryonic antigens with experimentally induced hepatic lesions in the rat.
Topics: Animals; Antigens; Cadmium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Embryo, Mammalian; Fema | 1967 |
Diversity and nature of ribosomal pools in hepatoma 7800 and host liver.
Topics: Animals; Azaguanine; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin; | 1968 |
[Synergic oncogenic effect of 2-N-fluorenylacetamide and carbon tetrachloride on rat liver].
Topics: Adenoma, Bile Duct; Amides; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Fluo | 1968 |
[Synergic oncogenic action of 4-dimethylaminoazobenzole and carbon tetrachloride on rat liver].
Topics: Adenoma, Bile Duct; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Liver Cirrho | 1968 |
[Analysis of tumor transformation in tissues. II. Biochemical dedifferentiation in the process of cancerogenesis (changes in creatine kinase and alkaline phosphatase as an example)].
Topics: Alkaline Phosphatase; Animals; Anura; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transfor | 1970 |
The covalent binding of metabolites of tritiated 2-methyl-4-dimethylamino-azobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats.
Topics: Aniline Compounds; Animals; Azo Compounds; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatect | 1967 |
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1970 |
[Changes in creatine kinase activity in the presence of tumor processes in the liver].
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Creatine Kinase; Liver Neoplasms; Male; Mi | 1970 |
The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Ethanol; Fatty Li | 1971 |
Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.
Topics: Adenoma, Bile Duct; Animals; Bile Ducts; Carbon Tetrachloride; Drug Synergism; Kidney Neoplasms; Liv | 1973 |
[Possible involvement of soluble anorganic pyrophosphatase in cancerification (rat liver following diethylnitrosamine and CCl4)].
Topics: Animals; Carbon Tetrachloride; Enzyme Activation; Injections, Intraperitoneal; Liver; Liver Neoplasm | 1972 |
The relation between experimental liver carcinoma and liver cirrhosis induced by simultaneous administration of p-dimethylaminoazobenzene and carbon tetrachloride.
Topics: Animals; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms; p-Dimethylamino | 1967 |
Experimental liver carcinoma and liver cirrhosis induced by p-dimethylaminoazobenzene after preliminary carbon tetrachloride injections.
Topics: Animals; Azo Compounds; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms; | 1967 |
The relation between experimental liver carcinoma and liver cirrhosis induced by successive administration of p-dimethylaminoazobenzene and carbon tetrachloride.
Topics: Animals; Body Weight; Carbon Tetrachloride; Hyperplasia; Liver; Liver Cirrhosis; Liver Neoplasms; p- | 1967 |
The role of mutations in liver tumor induction in mice.
Topics: Animals; Carbon Tetrachloride; Female; Liver Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neopla | 1972 |
Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine. Effect of prior treatment with 3-methylcholanthrene, phenobarbitone, dimethylformamide, diethyl-formamide, aminoacetonitrile, ethionine and carbon tetrachloride.
Topics: Amides; Animals; Carbon Tetrachloride; Carcinogens; Dimethylformamide; Endoplasmic Reticulum; Ethion | 1971 |
Development of tumor in the course of spontaneous restoration of carbon tetrachloride induced cirrhosis of the liver in rats.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Liver Neoplasms; Rats | 1965 |
Tumor induction as a measure of genetic damage and repair in somatic cells of mice.
Topics: Animals; Carbon Tetrachloride; Chromosome Aberrations; Liver Neoplasms; Liver Regeneration; Mice; Ne | 1968 |
Metabolic profiles during carcinogenesis and related conditions in hepatic tissue.
Topics: Amino Acids; Animals; Blood Proteins; Carbon Dioxide; Carbon Tetrachloride; Carcinogens; Hepatic Duc | 1965 |