carbon tetrachloride has been researched along with Liver Cirrhosis in 1388 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Curcumin attenuates liver injury induced by ethanol, thioacetamide, iron overdose, cholestasis and acute, subchronic and chronic carbon tetrachloride (CCl(4)) intoxication; moreover, it reverses CCl(4) cirrhosis to some extent." | 8.85 | Pharmacological actions of curcumin in liver diseases or damage. ( Muriel, P; Rivera-Espinoza, Y, 2009) |
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 8.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| "We studied the impact of IFC-305 on a carbon tetrachloride-induced liver fibrosis model in Wistar male rats at 4, 6, and 8 weeks." | 8.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 7.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| " The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis." | 7.91 | α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy. ( Gui, S; Liu, G; Liu, J; Lu, B; Pian, L, 2019) |
| "Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury." | 7.83 | Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. ( Barta, I; Chow, LN; Crawford, J; Gusti, V; Hughes, MR; Lecour, S; Lo, B; Manisali, I; McNagny, KM; Ng, BY; Schreiner, P; Scott, RW; Simonson, E; Underhill, TM; Webb, M, 2016) |
| ", quercetin encapsulated in PAG (p-aminophenyl-1-thio-β-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl₄)-mediated liver cirrhosis model." | 7.83 | Nanoparticle Based Delivery of Quercetin for the Treatment of Carbon Tetrachloride Mediated Liver Cirrhosis in Rats. ( Akhtar, M; Arora, I; Javed, K; Rastogil, S; Samim, M; Verma, SK, 2016) |
| "In cirrhotic rats with ascites: (a) pentoxifylline as well as norfloxacin reduced intestinal bacterial overgrowth and bacterial translocation and prevented spontaneous bacterial peritonitis; (b) pentoxifylline, but not norfloxacin, reduced oxidative stress in cecal mucosal." | 7.78 | Effects of pentoxifylline on intestinal bacterial overgrowth, bacterial translocation and spontaneous bacterial peritonitis in cirrhotic rats with ascites. ( Acevedo, J; Brusasco, C; Corradi, F; Fernández, J; Fernández-Varo, G; Gines, P; Mosbah, IB; Navasa, M; Pelosi, P; Ramirez, MJ; Rocco, PR; Seva-Pereira, T; Silva, A; Vila, J, 2012) |
| " Forty Sprague-Dawley rats with carbon tetrachloride-induced liver cirrhosis and 20 control rats were intraperitoneally administered a single dose of DEG, and randomly killed 1, 2, 5 or 8 days following exposure." | 7.77 | Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase. ( , 2011) |
| " NaHS protected liver function, attenuated liver fibrosis, inhibited inflammation, and reduced the portal pressure, evidenced by the alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), albumin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and soluble intercellular adhesion molecule (ICAM)-1, liver histology, hepatic hydroxyproline content and α-smooth muscle actin (SMA) expression." | 7.77 | Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. ( Dong, X; Jiang, H; Jiang, X; Kang, K; Kanwar, JR; Li, J; Pan, S; Qiao, H; Sun, X; Tan, G; Zhao, M, 2011) |
| "To clarify the effects of 1 alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) on bone growth, strength, and turnover in growing rats with liver cirrhosis induced by carbon tetrachloride (CCl(4)) injection, groups of 4-week-old male Wistar rats (n = 10, each) were injected intraperitoneally with CCl(4) twice weekly for 7 weeks." | 7.72 | Effects of 1,25(OH)2D3 on turnover, mineralization, and strength of bone in growing rats with liver cirrhosis induced by administration of carbon tetrachloride. ( Ikeda, S; Nakamura, T; Okimoto, N; Otomo, H; Sakai, A; Tanaka, S; Tsurukami, H, 2003) |
| " The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl(4)." | 7.71 | Dobutamine prevents experimental postintoxication liver cirrhosis in mice. ( Eremeev, AV; Setkov, NA; Vinokurov, AP, 2002) |
| " To clarify the role of the sympathetic nervous system in apoptosis that occurs in chronic liver damage and following the promotion of liver cirrhosis, we studied a carbon tetrachloride (CCl4)-induced liver injury model, using spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and chemically sympathectomized WKY." | 7.71 | The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes. ( Akiyama, Y; Hamanaka, Y; Hamasaki, K; Hsu, CT; Ito, M; Naito, S; Nakashima, M; Ohtsuru, A; Sekine, I, 2001) |
| "The present study was undertaken to determine the effect of ischemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride (CCl4) in rats by the evaluation of lipid peroxidation products (LPO)." | 7.70 | Effects of ischemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride in rats. ( Belló-Klein, A; Kalil, AN; Lucas, ML; Mauri, M; Menti, E; Pereira-Lima, J; Pereira-Lima, L; Rhoden, CR; Rhoden, EL; Zettler, CG, 2000) |
| "Plasma levels of the lysosomal enzymes, beta-hexosaminidase and beta-glucuronidase, were analyzed in rats with carbon tetrachloride induced liver cirrhosis." | 7.67 | Lysosomal enzymes in plasma, liver and spleen from rats with carbon tetrachloride-induced liver cirrhosis. ( Bengmark, S; Hägerstrand, I; Hultberg, B; Isaksson, A; Joelsson, B; Melén, K, 1985) |
| "The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat." | 7.66 | Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat. ( de Heer, K; Kloeppel, G; Sauer, HD; Werner, B, 1980) |
| " The lipid changes were induced either through essential fatty acid (EFA) deficiency or through carbon tetrachloride-induced liver cirrhosis." | 7.65 | Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat. ( Lekholm, U; Wallenius, K, 1976) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 6.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "Mangiferin has many pharmacological activities." | 5.91 | Mangiferin relieves CCl4-induced liver fibrosis in mice. ( Fan, S; Huang, C; Liu, C; Yin, L; Zhang, L, 2023) |
| "Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage." | 5.72 | Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats. ( Albogami, SM; Alotaibi, SS; Batiha, GE; Elewa, YHA; Makled, S; Mostafa-Hedeab, G; Yassin, F; Zein, N, 2022) |
| "Glabridin is an active ingredient extracted from the root of Glycyrrhiza glabra." | 5.72 | Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice. ( Gu, J; Li, H; Sun, J; Xu, W; Yuan, N; Zhang, H; Zhang, L, 2022) |
| "Mosapride significantly improves intestinal motility in liver cirrhosis, ultimately leading to the reduction in plasma endotoxin levels and bacterial translocation." | 5.51 | The influence of mosapride on gut microbiota of carbon tetrachloride-induced cirrhosis rats based on 16S rRNA gene sequencing. ( Chen, D; Feng, H; Liu, Y; Xiong, J; Xu, H; Xu, J, 2022) |
| "Carvedilol is a first‑line pharmacological treatment of PHT." | 5.51 | Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis. ( Li, G; Li, Z; Ling, L; Meng, D; Wang, G; Zhang, C, 2019) |
| "Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich extracellular matrix produced by myofibroblasts." | 5.51 | Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. ( Beckett, JD; Bedja, D; Butcher, JT; Chen, Y; Creamer, TJ; Dietz, HC; Gould, RA; Hata, S; Kim, DH; MacFarlane, EG; Mitzner, W; Nagpal, V; Rouf, R; Seman-Senderos, MA; Warren, DS, 2019) |
| "Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively." | 5.48 | Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 5.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities." | 5.39 | Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. ( Dang, X; Dong, L; Jia, M; Jiang, J; Lu, X; Shi, H; Zhao, G; Zhao, J, 2013) |
| "Portal hypertension is triggered by vasodilation due to impaired contraction of extrahepatic vessels." | 5.35 | Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. ( Heller, J; Hennenberg, M; Kohistani, AZ; Sauerbruch, T; Trebicka, J, 2009) |
| "However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations." | 5.32 | Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice. ( Jiang, Y; Kang, YJ; Liu, J; Waalkes, M, 2004) |
| "The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 5.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
| " Curcumin attenuates liver injury induced by ethanol, thioacetamide, iron overdose, cholestasis and acute, subchronic and chronic carbon tetrachloride (CCl(4)) intoxication; moreover, it reverses CCl(4) cirrhosis to some extent." | 4.85 | Pharmacological actions of curcumin in liver diseases or damage. ( Muriel, P; Rivera-Espinoza, Y, 2009) |
| " To establish new clinical therapies for patients with liver cirrhosis using autologous BMC, we developed a new in vivo murine model using green fluorescent protein (GFP) and repeated carbon tetrachloride (CCl(4)) injection." | 4.84 | Autologous bone marrow cell infusion therapy for liver cirrhosis. ( Sakaida, I, 2008) |
| " In carbon tetrachloride-induced micronodular cirrhosis, portal sinusoidal flow, which reaches liver parenchyma, is high, and this is more pronounced in the presence of ascites." | 4.81 | Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow. ( Reichen, J; Sägesser, H; Van de Casteele, M; Zimmermann, H, 2001) |
| " Fibrotic mice received a specific FAP inhibitor (FAPi) at 2 doses orally for 2 weeks during parenchymal fibrosis progression (6 weeks of carbon tetrachloride) and regression (2 weeks off carbon tetrachloride), and with biliary fibrosis (Mdr2-/-)." | 4.31 | Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis. ( Abe, H; Aslam, M; Jia, JD; Kim, YO; Klein, T; Park, KS; Schuppan, D; Yan, XZ; Yang, AT; You, H; Zhao, XY, 2023) |
| "Morphine alone, produced insignificant changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic hydroxyproline (Hyp), malondialdehyde (MDA), and superoxide dismutase (SOD) levels and exerted significant antinociception in the pain models." | 4.31 | Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats. ( Afify, EA; Bedair, AF; El-Mezayen, NS; Wahid, A, 2023) |
| "Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice." | 4.31 | Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023) |
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 4.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| "We studied the impact of IFC-305 on a carbon tetrachloride-induced liver fibrosis model in Wistar male rats at 4, 6, and 8 weeks." | 4.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "Lycopene significantly reduced the liver/body weight ratio, and AST (P=0." | 4.31 | Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats. ( Hao, W; Jiang, Y; Li, W; Wang, G; Yu, TT, 2023) |
| " Therefore, this study aimed to investigate the role of FRFRD, rich in quercetin and kaempferol, in liver fibrosis induced by CCl4." | 4.31 | Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking. ( Aghaei, M; Ghanadian, M; Hashemnia, M; Moezzi, ND; Mohammadalipour, A; Rostami, M, 2023) |
| "Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis." | 4.31 | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |
| "After one week of injection of carbon tetrachloride-olive oil, the rats in the model group increased their body weight slowly, the abdominal circumference of the model rats continued to increase with time." | 4.12 | Qi Sui Zhu Shui Plaster Inhibits AQP1 and MAPK Signaling Reduces Liver Damage Induced by Cirrhotic Ascites. ( Huang, YL; Li, M; Liu, Y; Song, ZH; Zhang, RZ, 2022) |
| "Our findings demonstrate that didymin can ameliorate liver fibrosis, which is mainly attributed to the inhibition of ERS, inflammation, and glycerophospholipid metabolism." | 4.12 | Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics. ( Fang, B; Huang, Q; Li, C; Li, Y; Lin, X; Xiong, Y, 2022) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "The effects of the miR-125a/VDR axis on hepatic fibrosis and its underlying mechanisms were investigated in a carbon tetrachloride (CCl4)-induced mouse model and patients with liver cirrhosis by immunohistochemistry, real-time PCR, Western blotting, and luciferase reporter assay." | 4.02 | MicroRNA-125a/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis. ( Fan, Z; He, W; Liu, L; Ni, W; Wang, X; Zhao, L, 2021) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 3.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| " The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis." | 3.91 | α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy. ( Gui, S; Liu, G; Liu, J; Lu, B; Pian, L, 2019) |
| "Canine BM cells were harvested and cultured, and the resultant BMSCs were returned to carbon tetrachloride (CCl4)-induced liver cirrhosis model canines via either a peripheral vein (Vein group) or hepatic artery (Artery group)." | 3.91 | Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model. ( Aibe, Y; Fujisawa, K; Matsuda, T; Matsumoto, T; Nishimura, T; Sakaida, I; Sasaki, R; Takami, T; Tani, K; Taura, Y; Yamamoto, N, 2019) |
| "Our findings indicate that fraxetin is effective in preventing liver fibrosis through inhibiting inflammation and hepatocytes apoptosis which is associated with regulating NF-κB/IκBα, MAPKs and Bcl-2/Bax signaling pathways in rats." | 3.91 | Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways. ( Gu, Y; Li, S; Song, F; Wang, R; Wang, Y; Wu, B; Yuan, Y, 2019) |
| " We examined the effects of an HMB-enriched diet in healthy rats and rats with liver cirrhosis induced by multiple doses of carbon tetrachloride (CCl4)." | 3.91 | Effects of beta-hydroxy-beta-methylbutyrate supplementation on skeletal muscle in healthy and cirrhotic rats. ( Holeček, M; Vodeničarovová, M, 2019) |
| "The aim of the study was to examine whether a rat model of liver cirrhosis induced by carbon tetrachloride (CCl4) is a suitable model of muscle wasting and alterations in amino acid metabolism in cirrhotic humans." | 3.88 | Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis. ( Holeček, M; Vodeničarovová, M, 2018) |
| "Liver fibrosis/cirrhosis was induced in wild type and TGFβ overproducing transgenic mice by carbon tetrachloride and thioacetamide administration." | 3.85 | Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models. ( Bugyik, E; Dezső, K; Mózes, M; Nagy, P; Paku, S; Rókusz, A; Szücs, A; Veres, D, 2017) |
| "The effect of systemic treatment with adipose tissue-derived MSCs, pre-differentiated into hepatocytic cells, was investigated in a rat model of liver cirrhosis induced by chronic inhalation of carbon tetrachloride." | 3.85 | Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells. ( Brückner, S; Christ, B; Hempel, M; Roderfeld, M; Roeb, E; Schwill, F; Thonig, A; Zipprich, A, 2017) |
| " Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment." | 3.83 | CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. ( Aldridge, V; Buckley, CD; Croft, AP; Fear, J; Garg, A; Haldar, D; Hedegaard, D; Henderson, NC; Naylor, AJ; Newsome, PN; Reynolds, GM; Weston, CJ; Wilhelm, A, 2016) |
| "Liver fibrosis in model rats (n = 50) was produced by carbon tetrachloride (CCl4 ) injection." | 3.83 | Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T1 relaxation time in the rotating frame. ( Chan, Q; Hu, G; Li, Y; Liang, W; Lin, T; Lin, X; Quan, X; Zhang, X; Zhong, X, 2016) |
| "Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury." | 3.83 | Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. ( Barta, I; Chow, LN; Crawford, J; Gusti, V; Hughes, MR; Lecour, S; Lo, B; Manisali, I; McNagny, KM; Ng, BY; Schreiner, P; Scott, RW; Simonson, E; Underhill, TM; Webb, M, 2016) |
| ", quercetin encapsulated in PAG (p-aminophenyl-1-thio-β-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl₄)-mediated liver cirrhosis model." | 3.83 | Nanoparticle Based Delivery of Quercetin for the Treatment of Carbon Tetrachloride Mediated Liver Cirrhosis in Rats. ( Akhtar, M; Arora, I; Javed, K; Rastogil, S; Samim, M; Verma, SK, 2016) |
| "Curcumin significantly attenuated inflammation and fibrosis, as revealed by histological and biochemical analysis." | 3.83 | Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1. ( Chen, J; Huang, R; Liu, Y; Pan, Z; Sun, Z; Wang, G; Wang, J; Wu, C; Wu, H; Xia, J; Xiong, Y; Yan, X; Zhang, Z, 2016) |
| " Starting from the third week, rats were exposed to 40 % carbon tetrachloride (CCl4; 150 μl/100 g body weight twice weekly, initially 200 μl/100 g) treatment for a duration of 8 weeks." | 3.81 | A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-β1 and Suppresses Ongoing Hepatic Fibrosis. ( Dang, S; Jia, X; Li, Y; Wang, W; Wang, X; Wang, Y; Zhai, S, 2015) |
| " Here we describe a syngeneic orthotopic HCC model in immunocompetent mice with liver cirrhosis induced by carbon tetrachloride (CCl4) that recapitulates key features of human HCC." | 3.81 | An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. ( Bardeesy, N; Chen, Y; Duda, DG; Fan, C; Hato, T; Huang, P; Jain, RK; Lauwers, GY; Ramjiawan, RR; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2015) |
| "Sorafenib--a broad kinase inhibitor--is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC." | 3.80 | Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. ( Chen, Y; Duda, DG; Duyverman, AM; Hiddingh, L; Huang, P; Huang, Y; Jain, RK; Koppel, C; Lauwers, GY; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2014) |
| "Osteoporosis was modeled in rats by chronic (6 months) treatment with omeprazole or serotonin, and bone tissue status was studied in experimental hepatic fibrosis and during serotonin treatment under conditions of hepatic fibrosis." | 3.80 | Experimental osteoporosis and its correction. ( Golubev, YY; Golubeva, GY; Lychkov, AE; Melent'ev, AS; Petrakov, AV; Puzikov, AM; Yarygin, VN, 2014) |
| "This study demonstrates that hesperidin prevents experimental necrosis and fibrosis." | 3.80 | Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor. ( Muriel, P; Pérez-Vargas, JE; Segovia, J; Shibayama, M; Tsutsumi, V; Zarco, N, 2014) |
| "Thirty adult male Sprague-Dawley rats were randomized into control group (n=10) and carbon tetrachloride-induced liver cirrhosis group (LC group, n=20)." | 3.79 | [Changes of sarcoplasmic reticulum calcium ATPase, titin, and nebulin expressions in the diaphragm of rats with liver cirrhosis]. ( Fang, Y; Ge, M; Guan, S; Ma, L; Zhang, W, 2013) |
| " The assays were evaluated using samples from a carbon tetrachloride (CCl₄) rat model of liver fibrosis and from patients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD)." | 3.79 | MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays. ( Han, M; Hogaboam, C; Karsdal, MA; Larsen, L; Leeming, DJ; Martinez, F; Nawrocki, A; Røssel Larsen, M; Sand, JM; Zheng, Q, 2013) |
| "In cirrhotic rats with ascites: (a) pentoxifylline as well as norfloxacin reduced intestinal bacterial overgrowth and bacterial translocation and prevented spontaneous bacterial peritonitis; (b) pentoxifylline, but not norfloxacin, reduced oxidative stress in cecal mucosal." | 3.78 | Effects of pentoxifylline on intestinal bacterial overgrowth, bacterial translocation and spontaneous bacterial peritonitis in cirrhotic rats with ascites. ( Acevedo, J; Brusasco, C; Corradi, F; Fernández, J; Fernández-Varo, G; Gines, P; Mosbah, IB; Navasa, M; Pelosi, P; Ramirez, MJ; Rocco, PR; Seva-Pereira, T; Silva, A; Vila, J, 2012) |
| " In the present experiments we investigated the efficiency of a primary hepatocyte mitogen 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOB) on two different liver cirrhosis/fibrosis models in mice induced by chronic administration of CCl(4) and thioacetamide respectively." | 3.78 | 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver. ( Bugyik, E; Dezso, K; Nagy, P; Paku, S; Szurián, K; Turányi, E, 2012) |
| "Droxidopa might be an effective therapeutic agent for hemodynamic and renal alterations of liver cirrhosis and should be tested in cirrhosis patients." | 3.78 | Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. ( Augustin, S; Brull, A; Coll, M; Esteban, R; Ezkurdia, N; Genescà, J; Guardia, J; Martell, M; Raurell, I; Rodriguez, S, 2012) |
| " To explore the role of MMP-2 in hepatic fibrogenesis, we employed two fibrosis models in mice; toxin (carbon tetrachloride, CCl4)-induced and cholestasis-induced fibrosis." | 3.77 | Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. ( Funaoka, Y; Kakinuma, S; Kamiya, A; Kiyohashi, K; Koshikawa, N; Miyoshi, M; Nakagawa, M; Nakauchi, H; Onozuka, I; Sakamoto, N; Seiki, M; Ueyama, M; Watanabe, M; Watanabe, T, 2011) |
| " Forty Sprague-Dawley rats with carbon tetrachloride-induced liver cirrhosis and 20 control rats were intraperitoneally administered a single dose of DEG, and randomly killed 1, 2, 5 or 8 days following exposure." | 3.77 | Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase. ( , 2011) |
| " NaHS protected liver function, attenuated liver fibrosis, inhibited inflammation, and reduced the portal pressure, evidenced by the alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), albumin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and soluble intercellular adhesion molecule (ICAM)-1, liver histology, hepatic hydroxyproline content and α-smooth muscle actin (SMA) expression." | 3.77 | Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. ( Dong, X; Jiang, H; Jiang, X; Kang, K; Kanwar, JR; Li, J; Pan, S; Qiao, H; Sun, X; Tan, G; Zhao, M, 2011) |
| " This study investigates the reversing capacity of an adenosine derivative compound (IFC305) on a rat model of liver cirrhosis and gene expression changes associated with it." | 3.76 | An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis. ( de Sánchez, VC; Hernández-Luis, F; Hernández-Muñoz, R; Loredo, ML; Martínez-Pérez, L; Pérez-Carreón, JI; Ramírez-Salcedo, J; Suárez-Cuenca, JA; Velasco-Loyden, G; Velázquez-Martínez, I; Vidrio-Gómez, S; Yañez-Maldonado, L, 2010) |
| "The aim of this study was to investigate the hepatoprotective effects of anthocyanidin delphinidin in carbon tetrachloride (CCl(4))-induced liver fibrosis in mice." | 3.76 | Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. ( Domitrović, R; Jakovac, H, 2010) |
| "6 g/kg bw) significantly reduced the serum levels of alanine aminotransferase and aspartate aminotransferase in rats treated with CCl4, and also decreased the thiobarbituric acid reactive substances, hydroxyproline and excessive inflammation in the livers of CCl4-treated rats." | 3.76 | Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats. ( Hsu, CC; Hsu, CL; Yen, GC, 2010) |
| " Female rats with carbon tetrachloride (CCl₄-induced liver cirrhosis were injected CM-DiI-labeled monocytes, CD14⁻ cells (1 x 10⁷ cells/rat) or saline via the portal vein." | 3.76 | The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis. ( Cao, Y; Cheng, X; Cui, L; Fan, D; Han, Y; Han, Z; Liang, J; Qiao, L; Shi, Y; Wang, J; Yan, L; Zhou, X, 2010) |
| " This study determined the role of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase deficiency in the development of hepatocellular necrosis, inflammation, and apoptosis in relation to fibrosis produced by chronic carbon tetrachloride (CCl(4)) administration." | 3.75 | Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. ( Aram, G; Liu, X; Mezey, E; Potter, JJ; Torbenson, MS; Wang, L, 2009) |
| "MR elastography of the liver was performed in 10 rats with hepatic fibrosis induced by intraperitoneal carbon tetrachloride (CCl(4)) injections and five normal rats." | 3.74 | Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat. ( Abarca-Quinones, J; Annet, L; Leclercq, I; Peeters, F; Salameh, N; Sinkus, R; Ter Beek, LC; Van Beers, BE, 2007) |
| " Acute carbon tetrachloride (CCl(4)) toxicity was similar in wild-type (WT), PAR-1(-/-), and PAR-1(+/-) mice as judged by aminotransferase levels, area of liver necrosis, and liver peroxidation measured by Fourier-transformed infrared spectroscopy." | 3.74 | Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis. ( Bioulac-Sage, P; Costet, P; Cubel, G; Deleris, G; Dugot-Senant, N; Gillibert-Duplantier, J; Haurie, V; Petibois, C; Rosenbaum, J; Rullier, A; Taras, D, 2008) |
| "To clarify the effects of 1 alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) on bone growth, strength, and turnover in growing rats with liver cirrhosis induced by carbon tetrachloride (CCl(4)) injection, groups of 4-week-old male Wistar rats (n = 10, each) were injected intraperitoneally with CCl(4) twice weekly for 7 weeks." | 3.72 | Effects of 1,25(OH)2D3 on turnover, mineralization, and strength of bone in growing rats with liver cirrhosis induced by administration of carbon tetrachloride. ( Ikeda, S; Nakamura, T; Okimoto, N; Otomo, H; Sakai, A; Tanaka, S; Tsurukami, H, 2003) |
| "Wistar rats were orally administrated carbon tetrachloride once a week for 14 weeks to induce liver cirrhosis." | 3.72 | High expression of the CD14 gene and interleukin-1beta gene in the liver and lungs of cirrhotic rats after partial hepatectomy. ( Arii, S; Imamura, M; Mori, A; Takeda, Y, 2003) |
| "We have previously reported that oral taurine administration reduced the frequency of painful muscle cramps in patients with liver cirrhosis, and that skeletal muscle taurine concentration was significantly decreased after exercise." | 3.72 | The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl4 administration. ( Bouscarel, B; Doy, M; Ikegami, T; Matsuzaki, Y; Miyakawa, S; Miyazaki, T; Tanaka, N, 2004) |
| "Obesity is associated with hyperleptinemia and is also a risk factor for fibrosis and severity of fibrosis in several chronic liver diseases." | 3.71 | Leptin is essential for the hepatic fibrogenic response to chronic liver injury. ( Farrell, GC; Leclercq, IA; Robertson, GR; Schriemer, R, 2002) |
| "Using the carbon tetrachloride liver cirrhosis rat model, the protective effect of the green tea extractive (GTE) on the liver cirrhosis was studied." | 3.71 | [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis]. ( Lu, R; Shen, X; Wu, M; Xiao, J, 2002) |
| " The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl(4)." | 3.71 | Dobutamine prevents experimental postintoxication liver cirrhosis in mice. ( Eremeev, AV; Setkov, NA; Vinokurov, AP, 2002) |
| " To clarify the role of the sympathetic nervous system in apoptosis that occurs in chronic liver damage and following the promotion of liver cirrhosis, we studied a carbon tetrachloride (CCl4)-induced liver injury model, using spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and chemically sympathectomized WKY." | 3.71 | The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes. ( Akiyama, Y; Hamanaka, Y; Hamasaki, K; Hsu, CT; Ito, M; Naito, S; Nakashima, M; Ohtsuru, A; Sekine, I, 2001) |
| "In an effort to develop a reproducible model of liver cirrhosis and esophageal varices, we administered phenobarbital (PhB) and carbon tetrachloride (CCl4) in 32 rats that had previously undergone complete devascularization of the left renal vein (DLRV)." | 3.71 | A rat model of liver cirrhosis and esophageal varices. ( Alatsakis, MB; Ballas, KD; Sakadamis, AK; Tzioufa-Asimakopoulou, V, 2001) |
| "To examine the expression of activin A, a member of the transforming growth factor (TGFbeta) superfamily, recently has been reported to be overexpressed in liver cirrhosis, in the course of carbon tetrachloride-induced rat hepatic fibrosis." | 3.71 | Expression changes of activin A in the development of hepatic fibrosis. ( Cheng, JL; Huang, X; Li, DG; Li, X; Lu, HM; Wang, ZR; Wei, HS; Xu, QF; Zhan, YT; Zhou, X, 2001) |
| "The present study was undertaken to determine the effect of ischemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride (CCl4) in rats by the evaluation of lipid peroxidation products (LPO)." | 3.70 | Effects of ischemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride in rats. ( Belló-Klein, A; Kalil, AN; Lucas, ML; Mauri, M; Menti, E; Pereira-Lima, J; Pereira-Lima, L; Rhoden, CR; Rhoden, EL; Zettler, CG, 2000) |
| "Plasma levels of the lysosomal enzymes, beta-hexosaminidase and beta-glucuronidase, were analyzed in rats with carbon tetrachloride induced liver cirrhosis." | 3.67 | Lysosomal enzymes in plasma, liver and spleen from rats with carbon tetrachloride-induced liver cirrhosis. ( Bengmark, S; Hägerstrand, I; Hultberg, B; Isaksson, A; Joelsson, B; Melén, K, 1985) |
| "The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat." | 3.66 | Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat. ( de Heer, K; Kloeppel, G; Sauer, HD; Werner, B, 1980) |
| " The lipid changes were induced either through essential fatty acid (EFA) deficiency or through carbon tetrachloride-induced liver cirrhosis." | 3.65 | Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat. ( Lekholm, U; Wallenius, K, 1976) |
| " Rats who had carbon tetrachloride-induced liver cirrhosis without pancreatic damage showed no increased hepatic storage iron." | 3.65 | The effect of pancreatectomy and other agents on iron absorption and storage in the rat. ( Bell, TK; Neill, DW; Sinniah, R, 1973) |
| "In the context of basic research in liver fibrosis and cirrhosis, it is essential to keep in mind that the capacity of the organ to recover spontaneously might be a significant limitation to long-term studies that use experimental models of liver cirrhosis." | 2.82 | Liver cirrhosis: An overview of experimental models in rodents. ( Dias, ML; Dos Santos Goldenberg, RC; Faccioli, LAP; Paranhos, BA, 2022) |
| "Liver cirrhosis was produced by weekly feeding of CCl(4) for 8 weeks." | 2.77 | Gender different response to immunonutrition in liver cirrhosis with sepsis in rats. ( Chen, CY; Hwang, TL, 2012) |
| "And 47 medium chronic hepatitis B viral fibrosis patients were studied." | 2.70 | Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis. ( Cai, WM; Liu, RH; Weng, HL, 2001) |
| "Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia." | 2.66 | Rodent Models of Nonalcoholic Fatty Liver Disease. ( Gao, L; Xu, J; Zhong, F; Zhou, X, 2020) |
| "To model liver fibrosis in mice is important as mechanisms not only of fibrogenesis, but also of fibrolysis, need to be clearly defined." | 2.44 | Mouse models of liver fibrosis. ( Herkel, J; Lohse, AW; Weiler-Normann, C, 2007) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 2.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model, and the underlying mechanisms were partly dissected in vivo and in vitro." | 1.91 | Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling. ( Chen, GF; Chen, JM; Fu, YD; Gao, SQ; Hu, YH; Ji, Q; Liu, P; Liu, W; Mu, YP; Xiao, Z, 2023) |
| "To date, there is no drug available for liver fibrosis." | 1.91 | An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling. ( Fan, C; Gan, C; Liu, H; Su, X; Tan, Z; Xie, Y; Xue, T; Ye, T; Yue, L; Zhu, G, 2023) |
| "Liver fibrosis is a leading indicator for increased mortality and long-term comorbidity in NASH." | 1.91 | Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling. ( Chen, S; Cheng, J; Dong, L; Fu, R; Han, P; Li, R; Li, S; Liu, Z; Pei, H; Shen, X; Song, G; Song, Y; Wang, H; Wei, J; Wu, J; Yao, Q; Zhang, G; Zhang, S; Zhao, Y; Zhu, C; Zhu, J, 2023) |
| "Mangiferin has many pharmacological activities." | 1.91 | Mangiferin relieves CCl4-induced liver fibrosis in mice. ( Fan, S; Huang, C; Liu, C; Yin, L; Zhang, L, 2023) |
| "However, whether GLA ameliorates liver fibrosis or not is still unclear." | 1.91 | Glaucocalyxin A attenuates carbon tetrachloride-induced liver fibrosis and improves the associated gut microbiota imbalance. ( Chen, M; Hu, X; Lan, T; Ma, Q; Ma, Z; Qu, R; Zhang, W; Zhou, L, 2023) |
| "Liver fibrosis is a crucial progress to deteriorate liver disease." | 1.91 | E Se tea extract ameliorates CCl ( Cao, J; Cheng, G; Khan, A; Liu, Y; Sun, P; Wang, Z; Zhao, T; Zhou, W, 2023) |
| " Rodent models of D-GalN-induced fibrosis are not recommended due to the long incubation period and weak toxic effect." | 1.91 | Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity. ( Bogunia, E; Czekaj, P; Grajoszek, A; Hermyt, M; Kolanko, E; Król, M; Limanówka, Ł; Michalik, M; Pająk, J; Prusek, A; Sikora, B; Skubis-Sikora, A, 2023) |
| "Excessive liver fibrosis is frequently observed in chronic liver diseases and associated with decline of liver functions." | 1.91 | Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis. ( Guo, Y; Li, Z; Wu, X; Zhao, Z; Zhu, Y, 2023) |
| "Axitinib is a new generation of potent multitarget tyrosine kinase receptor inhibitors, but its role in liver fibrosis remains unclear." | 1.91 | Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function. ( Gu, X; Hu, Y; Li, H; Li, J; Wu, D; Yang, C; Yang, Y; Zhang, F; Zhang, R; Zhou, H, 2023) |
| "Hepatitis C is a global health issue." | 1.91 | An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats. ( Akhtar, MF; Anwar, F; Khan, A; Shah, SA; Yasmeen, S, 2023) |
| "Liver fibrosis is a chronic inflammatory process characterized by the accumulation of extracellular matrix (ECM), which contributes to cirrhosis and hepatocellular carcinoma." | 1.91 | MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway. ( Bao, B; Chen, L; Chen, X; Li, C; Sun, Y; Zhou, Y, 2023) |
| "Hydronidone ameliorates liver fibrosis by inhibiting HSCs activation via Smad7-mediated TGFβRI degradation." | 1.91 | Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI. ( Cai, X; Dong, H; Guo, Y; Lu, J; Lu, L; Luo, X; Luo, Y; Qu, Y; Shen, B; Shen, Z; Sun, Z; Wang, J; Xu, X; Ye, Y; Zhang, Q; Zhou, C, 2023) |
| "Despite the fact that liver fibrosis is an intractable disease with a poor prognosis, effective therapeutic agents are not available." | 1.91 | Therapeutic Effects of Albumin-Fused BMP7 on 2 Experimental Models of Liver Fibrosis. ( Imafuku, T; Maeda, H; Maruyama, T; Minayoshi, Y; Nakano, T; Nishida, K; Takano, M; Toda, S; Watanabe, H, 2023) |
| "Using a liver cancer dataset from the International Cancer Genome Consortium, we developed an extensive in silico screening that identified a cluster of adamalysins co-expressed in livers from patients with hepatocellular carcinoma (HCC)." | 1.91 | ADAMTS12 is a stromal modulator in chronic liver disease. ( Arpigny, E; Azar, F; Bonnier, D; Colige, A; Dekky, B; Kalebić, C; Legagneux, V; Monseur, C; Théret, N, 2023) |
| "Triptolide is a natural immunosuppressive agent with demonstrated effectiveness in ameliorating liver fibrosis, but whether it exerts anti-liver fibrotic effects via immunoregulation remains obscure." | 1.91 | Triptolide attenuates CCL ( Feng, J; Jiang, S; Jiang, Y; Kong, J; Li, J; Li, X; Li, Y; Lian, H; Lu, Z; Zhang, F, 2023) |
| "Liver fibrosis is a common and reversible feature of liver damage associated with many chronic liver diseases, and its onset is influenced by sex." | 1.91 | Sex Drives Functional Changes in the Progression and Regression of Liver Fibrosis. ( Alberti, D; De Martin, S; Fantin, A; Gabbia, D; Pasqual, G; Russo, FP; Sayaf, K; Zanotto, I; Zaramella, A, 2023) |
| "Saffron can attenuate liver fibrosis by inhibiting the JAK/STAT3 pathway and the activation of hepatic stellate cell, providing a theoretical basis for the development of new anti-fibrotic drugs." | 1.91 | Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway. ( Han, Y; Huang, L; Qiu, Q; Su, W; Wang, Z; Yan, J; Yue, S; Zhou, Q, 2023) |
| "At present, liver fibrosis is a major challenge of global health." | 1.72 | Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells. ( Chen, Z; Cheng, X; Li, D; Li, Y; Wang, S; Xiong, Y; Xu, Y; Zheng, WV; Zhou, T, 2022) |
| "The changes that follow liver fibrosis were assessed by measurement of hepatic enzymes (ALT, AST and ALP), histopathological examination using hematoxylin and eosin stain, special stains, and α-smooth muscle actin (α-SMA) immunostaining, measuring oxidative stress markers (MDA, GSH, NOx and MnSOD) and transforming growth factor-beta 1 (TGF-β1) in liver." | 1.72 | Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride. ( Ahmed, AA; Ahmed, MA; El-Bakry, MH; Hasan, A; Omar, ZMM, 2022) |
| "Liver fibrosis is initial stage of any chronic liver disease and its end stage is develops into cirrhosis." | 1.72 | Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model. ( Afridi, SG; Ayaz, M; Iqbal, M; Khan, A; Khan, B; Khan, HA; Quraish, S; Rafiq, H; Shams, S; Sher, A; Siraj, F, 2022) |
| "SGHXHYF ameliorated CCl4-induced liver fibrosis by inhibiting the TGF-β1/Smad signaling pathway." | 1.72 | Shugan Huoxue Huayu Fang attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-β1/Smad signaling. ( Guo, HB; Liu, L; Shao, CP; Wang, L; Xu, YQ; Zhou, YM, 2022) |
| "6-Shogaol is a biologically active substance derived from the rhizome of Zingiber officinale Roscoe with anti-tumor, anti-inflammatory, and antioxidant properties." | 1.72 | 6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway. ( Chai, YN; Chen, LY; Duan, F; Duan, FY; Han, XY; Qiu, JL; Zhang, HJ, 2022) |
| "Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage." | 1.72 | Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats. ( Albogami, SM; Alotaibi, SS; Batiha, GE; Elewa, YHA; Makled, S; Mostafa-Hedeab, G; Yassin, F; Zein, N, 2022) |
| "Liver fibrosis is an independent contributor of chronic liver diseases, and regressing liver fibrosis is considered a potential therapeutic target for chronic liver diseases." | 1.72 | Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation. ( Chen, XF; Ji, S, 2022) |
| "Carbon tetrachloride was used to establish the liver fibrosis model." | 1.72 | Mechanism of dact2 gene inhibiting the occurrence and development of liver fibrosis. ( Huang, S; Jiang, T; Qian, X; Wen, Z; Xiao, J; Xiong, M; Yin, M, 2022) |
| "GZFL may prevent the progression of liver fibrosis by regulating the Nrf2/ heme oxygenase-1 and NF-κB signaling pathways, thereby highlighting its role in the management of liver fibrosis." | 1.72 | Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice. ( Baogui, XU; Falei, Y; Jiawen, Z; Xianjun, D; Xiaoxiao, T; Zhongliang, L; Zuisu, Y, 2022) |
| "Non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis results in the encapsulation of injured liver parenchyma by a collagenous scar mainly imputable to hepatic stellate cells' activation." | 1.72 | Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis. ( Alisi, A; Bianchi, M; Braghini, MR; Comparcola, D; Condorelli, AG; Conti, LA; Crudele, A; De Stefanis, C; Gurrado, F; Lioci, G; Mosca, A; Nobili, R; Panera, N; Sartorelli, MR; Scoppola, V; Smeriglio, A; Svegliati-Baroni, G; Trombetta, D, 2022) |
| "Patients with liver fibrosis who have pain in the liver region may have changed nerve factors." | 1.72 | Neurotrophic factors stimulate the activation of hepatic stellate cells in liver fibrosis. ( Li, Q; Liu, C; Liu, XL; Ma, WT; Sun, TT; Tao, L; Wu, L; Yang, GY; Zhang, W, 2022) |
| "Furthermore, CCl4-induced liver fibrosis in mice was evaluated by performing liver function tests, including serum ALT and AST, total bilirubin, and albumin to assess liver injury and by performing H&E and Sirius red staining to determine the degree of liver fibrosis." | 1.72 | Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl ( Gurau, Y; Jeong, YJ; Munakarmi, S; Park, HS; Risal, P; Shin, HB; Shrestha, J, 2022) |
| "However, the role of ARK5 in liver fibrosis remains largely unexplored." | 1.72 | Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis. ( Gao, C; Hong, J; Kang, Z; Li, J; Qu, H; Wu, J; Xiao, Y; You, Y, 2022) |
| "Glabridin is an active ingredient extracted from the root of Glycyrrhiza glabra." | 1.72 | Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice. ( Gu, J; Li, H; Sun, J; Xu, W; Yuan, N; Zhang, H; Zhang, L, 2022) |
| "On this basis, the effect of FTA on liver fibrosis was evaluated." | 1.72 | [Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism]. ( Guo, Q; Huang, ZL; Ji, LL; Lu, B; Zhang, Y, 2022) |
| "The increasing incidence of chronic liver fibrosis is one of the major health challenges in the world." | 1.72 | HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis. ( Lan, H; Li, H; Xing, B, 2022) |
| "A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes and decreasing the downstream inflammatory response." | 1.72 | Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice. ( Liu, LL; Wang, JH; Wang, L; Zhao, TJ; Zheng, Y, 2022) |
| "Chronic hepatitis B (CHB) patients with liver fibrosis were enrolled and assigned to receive either nucleoside/nucleotide analogues (NAs) or NAs plus YQHX." | 1.62 | Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling. ( Dong, S; Hou, M; Li, L; Li, W; Liu, L; Nan, Y; Tang, Y; Zhang, X; Zhang, Y; Zhao, D; Zhao, W, 2021) |
| "However, successful therapy for liver fibrosis is still lacking." | 1.62 | Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl ( Ding, Y; Huang, C; Li, J; Ma, T; Xu, S; Zhang, Y; Zhao, H; Zhu, H, 2021) |
| "Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer." | 1.62 | Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling. ( Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M, 2021) |
| " However, the pharmaceutical application of AA is limited by low oral bioavailability and poor targeting efficiency." | 1.62 | Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis. ( Pan, JC; Tu, LL; Yin, LN; Zhang, Y; Zhang, YW; Zheng, GL, 2021) |
| " Groups D, E, and F were intragastrically dosed with ZQRGD." | 1.62 | Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis. ( Che, JY; Chen, TT; He, J; He, Y; Shao, M; Shi, LP; Wang, J; Xie, T; Yuan, Z; Zhou, M, 2021) |
| "Liver fibrosis is a major medical problem with high mortality and morbidity rates where the formation of regenerative nodules and cirrhosis leads to loss of liver function and may result in the development of hepatocellular carcinoma." | 1.62 | Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis. ( Abo-Elmatty, DM; El-Demerdash, RS; Elminshawy, HH; Khalil, MR; Mehanna, ET; Mesbah, NM, 2021) |
| "To investigate whether QGJWS inhibits liver fibrosis in rats and to reveal its potential mechanisms." | 1.62 | Ameliorative effects of Qingganjiuwei powder, a traditional Mongolian medicine, against CCl ( Gao, L; Ge, H; Li, Y; Su, Y; Wang, A; Yu, C, 2021) |
| "Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury." | 1.62 | The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. ( Asaryan, A; Beaven, SW; Borawski, J; Cantor, RM; Carbone, W; Civelek, M; Clerkin, K; French, S; Fuqua, BK; Haroutunian, SG; Hui, ST; Knehr, J; Loureiro, J; Lusis, AJ; Magyar, C; Mehrabian, M; Pan, C; Parks, BW; Renaud, N; Roma, G; Tuominen, I; Ukomadu, C; Wroblewski, K, 2021) |
| "Sustained progression of liver fibrosis leads to cirrhosis, even hepatocellular carcinoma." | 1.62 | Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T ( Hu, Y; Li, Z; Liu, G; Ni, M; Wang, L; Wen, X; Yang, Y; Yu, H, 2021) |
| "In the latter 3 groups, liver fibrosis was established by treatment with CCl4." | 1.62 | Dietary fiber regulates intestinal flora and suppresses liver and systemic inflammation to alleviate liver fibrosis in mice. ( Li, MM; Li, XA; Nie, D; Zhou, Y; Zuo, L, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, and it is closely associated to obesity, type 2 diabetes mellitus, and dyslipidemia." | 1.62 | Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice. ( Appendino, G; Carmona-Hidalgo, B; García-Martín, A; González-Mariscal, I; Muñoz, E; Prados, ME; Ruiz-Pino, F; Tena-Sempere, M, 2021) |
| "Liver fibrosis is a necessary stage in the development of chronic liver diseases to liver cirrhosis." | 1.62 | PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis. ( Cheng, P; Guo, C; Wu, J; Yu, Q, 2021) |
| "Treatment with lenvatinib also suppressed platelet-derived growth factor-BB-stimulated proliferation, chemotaxis and vascular endothelial growth factor-A production, as well as basic fibroblast growth factor-induced LX-2 proliferation." | 1.62 | Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis. ( Akahane, T; Ishida, K; Kaji, K; Kawaratani, H; Moriya, K; Namisaki, T; Nishimura, N; Ogawa, H; Takagi, H; Takaya, H; Yoshiji, H, 2021) |
| "Hepatic injury progression to liver cirrhosis and cancer is a serious health issue across the world." | 1.62 | Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio. ( Ijaz, B; Koloko, BL; Malik, A; Rehman, S; Shahid, AA; Tariq, S, 2021) |
| "Liver fibrosis is the result of an excessive accumulation of extracellular matrix that develops when inflammation and chronic injury form scar tissue in the liver." | 1.62 | Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice. ( A M Alameen, A; Alzahrani, B; Tantawy, A, 2021) |
| "Liver fibrosis is a critical health issue in the world due to its rapidly increasing prevalence." | 1.62 | 5-methoxytryptophan alleviates liver fibrosis by modulating FOXO3a/miR-21/ATG5 signaling pathway mediated autophagy. ( Chen, L; Lin, YH; Liu, M; Tang, SG; Tong, M; Zheng, Q; Zhu, YM, 2021) |
| "Liver fibrosis was attenuated in mice with Tgr5 depletion." | 1.62 | Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis. ( Bian, H; Gao, X; Huang, F; Jia, W; Jiang, R; Liu, P; Liu, Z; Qiu, J; Rajani, C; Sun, B; Wang, X; Wu, Y; Xie, G; Zhang, X; Zhao, A; Zhao, S; Zheng, X, 2021) |
| "Astilbin treatment significantly decreased collagen production, inflammatory response, and oxidative stress in vivo." | 1.62 | Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. ( Fan, XP; Sun, XH; Wang, ZH; Zhang, H, 2021) |
| "TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis." | 1.62 | Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries. ( Ge, G; Lin, M; Peng, YJ; Ren, Z; Shang, G; Tang, XT; Wang, SS; Yin, X; Yuan, J; Zhou, BO, 2021) |
| "Liver fibrosis is a common feature of liver dysfunction during chronic liver diseases and is frequently associated with angiogenesis, a dynamic process that forms new blood vessels from preexisting vasculature." | 1.62 | miR-30c inhibits angiogenesis by targeting delta-like ligand 4 in liver sinusoidal endothelial cell to attenuate liver fibrosis. ( Cai, X; Chen, L; Dong, H; Gu, T; Guo, Y; Li, B; Li, F; Lu, L; Ma, Z; Qu, Y; Shen, B; Zhang, Q, 2021) |
| "However, its roles in liver fibrosis remain to be determined." | 1.62 | Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis. ( Chen, J; Hu, R; Li, J; Sun, J; Xing, X; Zhou, Q; Zhu, Z, 2021) |
| "Liver fibrosis is one of the leading causes of morbidity and mortality worldwide but lacks any acceptable therapy." | 1.62 | Physalin B attenuates liver fibrosis via suppressing LAP2α-HDAC1-mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation. ( Chen, X; Kong, L; Leng, Y; Li, J; Luo, J; Yang, T; Ye, S; Yu, D; Zhang, H; Zhang, M; Zhang, Y; Zhu, X, 2021) |
| "Liver fibrosis is a common consequence of chronic liver diseases involved with the activation of hepatic stellate cells (HSCs) and endoplasmic reticulum (ER) stress." | 1.62 | Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells. ( Li, R; Liao, X; Tian, T; Yang, Q; Yu, L; Zhan, W, 2021) |
| "The main etiologies of liver fibrosis include nonalcoholic fatty liver disease (NAFLD), chronic viral hepatitis, as well as alcoholic and cholestatic liver disease." | 1.62 | Mouse Models of Liver Fibrosis. ( Ravichandra, A; Schwabe, RF, 2021) |
| "Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression." | 1.62 | Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells. ( Cheong, LY; Hoo, RLC; Lam, KSL; Li, J; Shu, L; Song, E; Wang, C; Wu, X; Xu, A; Ye, D; Zhang, Z; Zong, J, 2021) |
| "In conclusion, miR-455-3p acts as a liver fibrosis suppressor by targeting HDAC2, and its deficiency further aggravates the reversal phase of fibrosis." | 1.62 | The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics. ( Bu, F; Huang, C; Li, J; Meng, H; Pan, X; Wang, A; Wang, L; Yin, N; You, H; Zhang, Y, 2021) |
| "Liver fibrosis is a common characteristic of chronic liver diseases." | 1.62 | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. ( Chung, D; Lapenta, K; Nam, JH; Nathanson, MH; Robert, ME; Wang, Q; Yang, X; Zhang, B, 2021) |
| "Demand for a cure of liver fibrosis is rising with its increasing morbidity and mortality." | 1.62 | Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome. ( Choi, YJ; Hwang, J; Jun, DW; Kang, KW; Kim, H; Kim, HY; Kim, N; Kim, SK; Kim, YM; Lim, SC; Yoon, K, 2021) |
| "Liver fibrosis is a progression of chronic liver disease characterized by excess deposition of fibrillary collagen." | 1.62 | A triterpenoid-enriched extract of bitter melon leaves alleviates hepatic fibrosis by inhibiting inflammatory responses in carbon tetrachloride-treated mice. ( Chang, ML; Chen, HL; Hou, YC; Kung, HN; Lin, YT; Liu, JJ; Pan, MH; Tsai, PJ; Yu, CH, 2021) |
| "Liver fibrosis is a chronic liver disease with excessive production of extracellular matrix proteins, leading to cirrhosis, hepatocellular carcinoma, and death." | 1.62 | Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl ( Abbas, A; Ahmad, S; Ahmed, A; Ali, U; Chen, G; Hussain, A; Khan, H; Liu, D; Qiu, Z; Raza, F; Shafiq, M; Ullah, A; Usman, M; Zheng, M; Zhou, Z, 2021) |
| "Mice chronic liver fibrosis models were established and divided into the olive-induced control group, CCL4-induced control group, olive-induced TIM-4 interference group and CCL4-induced TIM-4 interference group." | 1.56 | TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway. ( Chen, G; Deng, M; Gong, J; Wang, J; Wu, H; Yuan, F, 2020) |
| "Previously, LQ was found to inhibit liver fibrosis progression." | 1.56 | Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis. ( Dong, P; Fan, S; Geng, W; Li, C; Xiao, Q; Zhao, B; Zheng, J; Zhou, G, 2020) |
| "Liver fibrosis was induced in mice using CCl4, and the differential expressions of several fibrosis-related long noncoding RNAs were detected in liver tissues." | 1.56 | Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. ( Chen, S; Luo, H; Ma, N; Tang, Y; Yu, F, 2020) |
| "Tanshinone IIA (TIIA) is a major component extracted from the traditional herbal medicine salvia miltiorrhiza (Danshen), which activates blood circulation and treats chronic hepatitis and liver fibrosis." | 1.56 | A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis. ( Dong, BS; Shi, MJ; Su, SB; Yan, XL; Yang, WN; Zhang, H, 2020) |
| "Apigenin (APG) is a flavonoid, which exhibits efficient anti-liver fibrosis activity, but its underlying mechanisms were rarely studied." | 1.56 | Transcriptomics and proteomics analysis of system-level mechanisms in the liver of apigenin-treated fibrotic rats. ( Hu, J; Qiao, M; Yang, J; Zhao, Y; Zhu, Y, 2020) |
| "Mice with liver fibrosis after BDL had increased hepatic PFKFB3; injection of 3PO immediately after the surgery prevented HSC activation and reduced the severity of liver fibrosis compared with mice given vehicle." | 1.56 | CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis. ( Bartrons, R; Fernandez, M; Gallego, J; Manzano, A; Mejias, M; Mendez, R; Naranjo-Suarez, S; Pell, N; Ramirez, M; Suñer, C, 2020) |
| "Chronic liver fibrosis was induced in experiment animals by recurrent injections of CCl4 for more than 5 weeks." | 1.56 | Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats. ( Abo-Zaid, MA; Ismail, AH; Shaheen, ES, 2020) |
| "The model of liver fibrosis was established by subcutaneous injection of rats with 40% CCl_4." | 1.56 | [Anti-fibrotic mechanism of Sedum sarmentosum total flavanones in inhibiting activation of HSC by regulating Smads]. ( DU, XH; Lin, YC; Liu, HF; Luo, HY, 2020) |
| "Agn prevents liver fibrosis through its attenuation of HSC activation and division through the suppression of NF-κB in in vitro and animal models." | 1.56 | Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling. ( Ding, L; Jin, W; Sheng, X; Wu, J; Xia, Z; Xu, Y; Zheng, J, 2020) |
| "Liver fibrosis is a serious chronic disease that developed by a coordinated interplay of many cell types, but the underlying signal transduction in individual cell type remains to be characterized." | 1.56 | RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines. ( Fan, Y; Ge, S; Huang, W; Ji, R; Liu, Z; Lu, C; Wei, J; Xiao, M; Zhang, J; Zhou, D, 2020) |
| "HGTLF could significantly improve liver fibrosis in mice." | 1.56 | Huagan tongluo Fang improves liver fibrosis via down-regulating miR-184 and up-regulating FOXO1 to inhibit Th17 cell differentiation. ( Cheng, Z; Geng, J; Hu, D; Huang, A; Qiu, Y; Tian, Y; Xuan, J, 2020) |
| "Liver fibrosis is a common part of the pathological development of many chronic liver diseases." | 1.56 | Camellia oil (Camellia oleifera Abel.) attenuates CCl ( Cao, Z; Du, H; Fang, Y; Fu, J; Kuang, T; Lei, X; Li, C; Liu, G; Liu, Q; Liu, Z; Qian, K; Xiao, Z; Xu, X; Zhang, J, 2020) |
| "Pelargonidin (PEL) is a natural anthocyanidin existing in blueberries, berries, strawberries, and red radishes and has been demonstrated to possess health beneficial effects." | 1.56 | Pelargonidin ameliorates CCl ( Li, HT; Li, XX; Shi, YS; Zhang, Y, 2020) |
| "Ursolic acid (UA) is a traditional Chinese medicine with anti-fibrotic effects, but the molecular mechanism underlying these effects is still unclear." | 1.56 | Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. ( Huang, C; Liu, C; Luo, F; Luo, Q; Wan, S; Zhu, X, 2020) |
| "The current research on the treatment of liver fibrosis mainly focuses on the activation of hepatic stellate cell, in addition to protecting liver cells." | 1.56 | Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice. ( Bai, J; Bi, Z; Li, H; Li, X; Ma, B; Ma, X; Ning, W; Shao, S; Wei, Y; Xie, C; Yang, C; Zhang, L; Zhang, R; Zhang, S; Zhou, H, 2020) |
| "Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease." | 1.56 | Multi-Omics Integration Highlights the Role of Ubiquitination in CCl ( Alonso, C; Aloria, K; Arizmendi, JM; Avila, MA; Azkargorta, M; Banales, JM; Barrio, R; Beraza, N; Bizkarguenaga, M; Delgado, TC; Elortza, F; Fernández-Ramos, D; Goikoetxea-Usandizaga, N; Juan, VG; Lachiondo-Ortega, S; Lectez, B; Lopitz-Otsoa, F; Lozano, JJ; Marin, JJG; Martínez-Chantar, ML; Mato, JM; Mayor, U; Mercado-Gómez, M; Rodríguez-Agudo, R; Serrano-Maciá, M; Simon, J; Sutherland, JD, 2020) |
| "Liver fibrosis will develop into liver cirrhosis unless the damaging factors are removed." | 1.56 | Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis. ( Guan, W; Lai, J; Lu, H; Sun, Y; Wu, X; Zhang, S, 2020) |
| "Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually." | 1.56 | Extracellular histones stimulate collagen expression ( Abrams, ST; Chen, PS; Cheng, ZX; Lin, ZQ; Toh, CH; Wang, GZ; Wang, Z; Yates, ED; Yu, Q; Yu, WP, 2020) |
| "The rats with liver fibrosis were randomly divided into model group, silybin group(43." | 1.56 | [Effect and mechanism of total flavonoids of Lichi Semen on CCl_4-induced liver fibrosis in rats, and prediction of Q-marker]. ( Feng, JF; Feng, YY; Li, F; Liang, JQ; Luo, WS; Xia, X; Xie, TF; Yan, JY, 2020) |
| "Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects." | 1.51 | Praziquantel ameliorates CCl ( Kong, D; Liu, J; Liu, X; Lu, Z; Qiu, J; Wang, Y; Xie, Y; Zhang, R; Zhou, C, 2019) |
| "Liver cirrhosis is a life-threatening consequence of liver fibrosis." | 1.51 | Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl ( Artmann, R; Bösch, F; de Toni, EN; Denk, G; Gerbes, AL; Hohenester, S; Kanitz, V; Mayerle, J; Mayr, D; Regel, I; Reiter, FP; Steib, CJ; Trauner, M; Wimmer, R; Ye, L; Ziesch, A, 2019) |
| "Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease." | 1.51 | New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019) |
| "However, persistent injuries cause liver fibrosis (LF) to evolve into cirrhosis, which promotes the development of hepatocellular carcinoma (HCC)." | 1.51 | Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. ( Bobbala, D; Ilangumaran, S; Kandhi, R; Khan, MGM; Mafanda, EK; Menendez, A; Nandi, M; Ramanathan, S, 2019) |
| "Liver fibrosis has been recognized as a major lesion of the liver that leads to liver cirrhosis/hepatocarcinoma and even to death in the end." | 1.51 | Hepatoprotection of Herpetospermum caudigerum Wall. against CCl ( Chen, C; Chen, LY; Deng Ba, DJ; Feng, X; Li, MH; Ruan, LY; Wang, JS; Xing, YX; Zhong, GJ, 2019) |
| "However, the role of ferroptosis in liver fibrosis remains poorly understood." | 1.51 | P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. ( Chen, A; Jia, Y; Li, M; Shao, J; Wang, F; Wang, L; Zhang, F; Zhang, Z; Zheng, S, 2019) |
| "Liver cirrhosis is the end stage of chronic liver disease, and the only radical treatment for decompensated liver cirrhosis is still liver transplantation." | 1.51 | Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells. ( Sakaida, I; Takami, T; Tani, K; Taura, Y, 2019) |
| "Galectin-8 (Gal-8) is downregulated in liver fibrosis." | 1.51 | Ginger potentiates the effects of silymarin on liver fibrosis induced by CCL4: the role of galectin-8. ( Abd-Alhaseeb, MM; Barka, K; Okda, TM; Ragab, NM, 2019) |
| "Carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and locostatin was injected intraperitoneally." | 1.51 | Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice. ( Jiang, H; Ma, J; Qiu, Y; Wang, M; Zhang, M; Zhao, X, 2019) |
| "In the BDL model, liver fibrosis and Kuppfer cell numbers were increased in IL-1Ra KO mice compared to wild type mice and wild type mice treated with IL-1Ra." | 1.51 | Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner. ( Balaphas, A; Buhler, LH; Clément, S; Lacotte, S; Meier, RPH; Meyer, J; Montanari, E; Morel, P; Muller, YD; Negro, F; Toso, C, 2019) |
| "We found NR could prevent liver fibrosis and reverse the existing liver fibrosis." | 1.51 | Nicotinamide riboside protects against liver fibrosis induced by CCl ( Huang, Y; Jiang, R; Jiang, X; Li, X; Ling, W; Pang, N; Pei, L; Qiu, Y; Wan, T; Wang, S; Yang, H; Yang, L; Ye, M; Zhang, Z; Zhou, Y, 2019) |
| "Both hepatotoxins showed leukocytosis, granulocytosis, and thrombocytopenia." | 1.51 | Hepcidin-orchestrated Hemogram and Iron Homeostatic Patterns in Two Models of Subchronic Hepatic injury. ( El-Mahmoudy, A; Gheith, I, 2019) |
| "MATERIAL AND METHODS A liver fibrosis mouse model induced by carbon tetrachloride (CCl4) intervention was employed in this study." | 1.51 | Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells. ( Cao, S; Deng, Z; Ge, S; Kong, F; Pan, Z; Zhang, S, 2019) |
| "In the animal model of liver fibrosis, all doses of volatile oil of CG significantly reduced the serum levels of AST, ALT, MDA, Hyp, γ-GT, LDH, ALP, and Alb." | 1.51 | Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats. ( Han, C; Qin, DM; Wang, XB; Xu, J; Zou, N, 2019) |
| "Liquiritigenin (LQ) is an aglycone of liquiritin and has been reported to protect the liver from injury." | 1.51 | Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal. ( Baek, SY; Jang, EJ; Kim, KY; Kim, SC; Kim, YW; Ku, SK; Lee, EH; Lee, JH; Park, JY; Park, KI; Suk, HY, 2019) |
| "Liver fibrosis is a progression of chronic liver disease with lacks effective therapies at present." | 1.51 | Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl ( Chen, Q; Dahan, A; Tan, W; Wei, L; Xue, J; Zhang, G; Zhang, H, 2019) |
| "Liver fibrosis is a serious health problem which is a critical cause of morbidity and mortality worldwide." | 1.51 | Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats. ( Abdel-Bakky, MS; Abo-Saif, AA; Mahmoud, NI; Messiha, BAS; Salehc, IG, 2019) |
| "In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatectomy (pHx)-induced liver regeneration." | 1.51 | Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers. ( Barnhoorn, MC; Coenraad, MJ; de Jonge-Muller, ESM; Hawinkels, LJAC; Molendijk, I; van der Helm, D; van Hoek, B; Verspaget, HW, 2019) |
| "Carvedilol is a first‑line pharmacological treatment of PHT." | 1.51 | Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis. ( Li, G; Li, Z; Ling, L; Meng, D; Wang, G; Zhang, C, 2019) |
| "Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) leading to impaired function and cirrhosis." | 1.51 | Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride. ( Agarwal, SK; Pedroza, M; Smith, J; To, S, 2019) |
| "Ketoconazole is a first orally available anti-fungal drug which has been reported as a potent inhibitor of human cytochrome P-450." | 1.51 | Hepatoprotective effect of ketoconazole in chronic liver injury model. ( Ahmed, M; Akhtar, U; Ali, G; Shehzad, U; Tayyeb, A, 2019) |
| "Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich extracellular matrix produced by myofibroblasts." | 1.51 | Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. ( Beckett, JD; Bedja, D; Butcher, JT; Chen, Y; Creamer, TJ; Dietz, HC; Gould, RA; Hata, S; Kim, DH; MacFarlane, EG; Mitzner, W; Nagpal, V; Rouf, R; Seman-Senderos, MA; Warren, DS, 2019) |
| "Procyanidin B2 (PB2) is a flavonoid extract abundant in grape seeds with anti-oxidant, anti-inflammatory and anti-cancer properties." | 1.51 | Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis. ( Chen, J; Chen, K; Dai, W; Fan, X; Feng, J; Guo, C; Ji, J; Li, J; Li, S; Liu, T; Mao, Y; Wang, C; Wang, F; Wu, J; Wu, L; Yu, Q; Zhang, J; Zhou, Y, 2019) |
| "It has been well established that liver fibrosis is characterized of excessive extracellular matrix (ECM) deposition in chronically damaged livers." | 1.48 | Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio. ( Hu, X; Li, J; Li, S; Lu, C; Qi, W; Yang, H; Zhang, M; Zong, Y, 2018) |
| "Here we established murine model of liver fibrosis and found that oroxylin A (40 mg/kg) could ameliorate angiogenesis in liver fibrosis may related to hypoxia inducible factor 1α (HIF-1α)." | 1.48 | Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. ( Bian, M; Chen, A; Chen, X; Guo, Q; Jin, H; Shao, J; Yang, X; Zhang, C; Zhang, F; Zhao, S; Zheng, S, 2018) |
| "Liver fibrosis is a pathological process of chronic liver diseases." | 1.48 | Recombinant truncated TGF‑β receptor II attenuates carbon tetrachloride‑induced epithelial‑mesenchymal transition and liver fibrosis in rats. ( Cao, Y; Chu, Y; Li, H; Li, L; Liu, J; Shi, Y; Yuan, X; Zhang, Z; Zheng, J, 2018) |
| " In conclusion, PS-modified NLCs nanoparticles prolonged the retention time of Cur, and enhanced its bioavailability and delivery efficiency to the livers, resulting in reduced liver fibrosis and up-regulating hepatic expression of HGF and MMP-2." | 1.48 | Enhanced efficacy of curcumin with phosphatidylserine-decorated nanoparticles in the treatment of hepatic fibrosis. ( Du, C; Feng, B; Lei, W; Pan, W; Wang, J; Wang, XJ; Wang, Y, 2018) |
| "Liver fibrosis is overly exuberant wound healing that leads to portal hypertension or liver cirrhosis." | 1.48 | Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis. ( Fan, X; Ge, S; He, J; Jia, R; Li, B; Li, P; Li, Y; Ma, X; Pan, H; Shang, Q; Wang, H; Wang, L; Yang, Z; Zhang, H; Zhu, L, 2018) |
| "Therapeutic interventions for liver fibrosis are still limited due to the complicated molecular pathogenesis." | 1.48 | Renin-angiotensin system inhibition ameliorates CCl ( Abdelghany, RH; El-Ahwany, E; Helal, NS; Mahmoud, AAA; Saber, S, 2018) |
| "Although BMSC administration reduced liver fibrosis, transplantation of BMSCs/MMP1 enhanced the reduction of liver fibrosis to a higher level." | 1.48 | Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats. ( Du, C; Jiang, M; Qin, J; Wang, Y; Wei, X; Xu, H; Xue, H; Zeng, W; Zhang, Y; Zheng, S; Zhou, D, 2018) |
| "Roles of miR-30a in liver fibrosis in vivo and in vitro were also analyzed." | 1.48 | MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition. ( Chen, B; Dong, P; Wang, W; Yu, F; Zheng, J; Zhou, MT, 2018) |
| "Liver fibrosis is an excessively reversible wound healing process and the fibrotic disorder is the activation of hepatic stellate cell that requires extensive alterations in gene expression." | 1.48 | Effect of histone deacetylase inhibitor on epithelial-mesenchymal transition of liver fibrosis. ( Abdelghany, HM; El-Tahawy, NF; Ramzy, MM; Zenhom, NM, 2018) |
| "Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively." | 1.48 | Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018) |
| "Treatment with eplerenone prevented the worsening of cirrhosis by blocking this ligand-independent activation of the MR." | 1.48 | The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis. ( Gekle, M; Hammer, S; Mildenberger, S; Pohl, S; Rabe, S; Schreier, B; Wolf, A; Zipprich, A, 2018) |
| "Celecoxib has been explored as a possible treatment of liver fibrosis with contradictory results, depending on the model." | 1.48 | Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. ( Hammock, BD; Harris, TR; Hwang, SH; Imai, DM; Kodani, S; Rand, AA; Yang, J, 2018) |
| "The effect of stevia on liver cirrhosis has not been previously investigated." | 1.48 | Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. ( Buendia-Montaño, LD; Camacho, J; Casas-Grajales, S; Galindo-Gómez, S; Hernández-Aquino, E; Muriel, P; Ramos-Tovar, E; Tsutsumi, V, 2018) |
| "Liver fibrosis is the final common pathway for almost all causes of chronic liver injury." | 1.48 | Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model. ( Alves de Castro, I; Barbisan, LF; Cogliati, B; Crespo Yanguas, S; da Silva, TC; Gijbels, E; Goes, BM; Maes, M; Pereira, IVA; Romualdo, GR; Sayuri Nogueira, M; Shestopalov, VI; Vinken, M; Willebrords, J, 2018) |
| "Furthermore, prolonged unresolved liver fibrosis may gradually progress to cirrhosis, and eventually evolve into hepatocellular carcinoma (HCC)." | 1.48 | Investigation of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced liver fibrosis in rats by ( Chen, ZN; Cheng, B; Guo, HW; Liang, YH; Liu, X; Liu, XW; Mo, YY; Ruan, JX; Song, FM; Song, H; Su, ZH; Tang, CL; Wu, F; Wu, JX; Yin, CL; Zheng, H; Zhu, HJ, 2018) |
| "Adding PSTPIP2 expression alleviates liver fibrosis and hepatic inflammation in mice by regulating macrophage polarization." | 1.48 | PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. ( Huang, C; Huang, HM; Li, HD; Li, J; Li, WX; Li, XF; Lv, XW; Meng, XM; Pan, XY; Wang, H; Wu, XQ; Yang, Y; Zhang, L, 2018) |
| "A rat model of liver fibrosis was generated by administering CCl4 via subcutaneous injection twice a week for 12 weeks." | 1.48 | Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats. ( Liu, F; Ma, Z; Qian, J; Wu, G; Zhang, J, 2018) |
| "However, the function of lncRNAs in liver fibrosis is largely unknown." | 1.48 | Integrated profiling of long non-coding RNAs and mRNAs identifies novel regulators associated with liver fibrosis. ( Liu, J; Ma, Y; Wang, J; Zhang, J; Zhang, Y; Zhu, J, 2018) |
| "Inhibition of ALR expression aggravates liver fibrosis, probably via promoting HSC migration and mitochondrial fusion." | 1.48 | Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell. ( Ai, WL; An, W; Dong, LY; Gao, J; Li, ZW; Wang, J; Wang, X; Wu, Y, 2018) |
| "piR-823 is increased in liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.48 | The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis. ( Jiang, H; Jiang, X; Tang, X; Wang, X; Wang, Y; Xie, X, 2018) |
| " Our findings support the further development of telmisartan prodrugs that enable infrequent dosing in the treatment of liver fibrosis." | 1.48 | Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs. ( Ackley, JC; Andersen, JN; Baddour, J; Blume-Jensen, P; Brady, SW; Chickering, DE; Economides, KD; Ehrlich, DC; Golder, MR; Held, EJ; Huh, SJ; Johnson, JA; Kopesky, PW; Liu, J; Neenan, AM; Nguyen, HV; Paramasivan, S; Reiter, LA; Saucier-Sawyer, JK; Shipitsin, MV; Vangamudi, B; Vohidov, F, 2018) |
| "Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic stellate cells (HSC)." | 1.46 | Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl ( Abou-Elela, SH; Elmahdy, NA; Salem, ML; Sarhan, NI; Sokar, SS, 2017) |
| "Although liver fibrosis is a major public health issue, there is still no effective drug therapy in the clinic." | 1.46 | Highly Selective Targeting of Hepatic Stellate Cells for Liver Fibrosis Treatment Using a d-Enantiomeric Peptide Ligand of Fn14 Identified by Mirror-Image mRNA Display. ( Bi, Q; Huang, L; Li, C; Li, Z; Liu, S; Shen, Q; Xie, J, 2017) |
| " 48 male Sprague-Dawley (SD) rats were randomized to the normal group, CCl4 model group, and two tanshinol treatment groups, including a lower dosage group as well as a higher dosage group." | 1.46 | Antifibrotic effects of tanshinol in experimental hepatic fibrosis by targeting PI3K/AKT/mTOR/p70S6K1 signaling pathways. ( Peng, R; Wang, R; Wang, S; Wang, Y; Wu, Y; Yuan, Y, 2017) |
| "Here, we use this strategy in the liver fibrosis induced by CCl4." | 1.46 | Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4. ( Hosseini, A; Kashani, IR; Khanlarkhani, N; Majidpoor, J; Mortezaee, K; Nekoonam, S; Pasbakhsh, P; Sabbaghziarani, F; Zendedel, A, 2017) |
| "In vivo liver fibrosis in mice was induced by intraperitoneally injections of CCl4 for eight weeks, and in vitro studies were performed on activated LX2 cells treated with transforming growth factor-β (TGF-β)." | 1.46 | Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway. ( Hao, C; Jianping, G; Xuanfei, L; Yanming, L; Zhujun, Y, 2017) |
| "Hyperoside was used to treat cardiovascular disease for many years in China." | 1.46 | The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. ( Chen, S; Li, L; Wu, T; Zou, L, 2017) |
| "We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main outcome)." | 1.46 | Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. ( Cabibi, D; Cammà, C; Craxì, A; Di Marco, V; Dongiovanni, P; Fargion, S; Ferri, N; Fracanzani, AL; Giordano, D; Grimaudo, S; Maggioni, M; Meroni, M; Petta, S; Pierantonelli, I; Pipitone, RM; Ruscica, M; Rychlicki, C; Svegliati-Baroni, G; Valenti, L, 2017) |
| "SC-43 significantly ameliorates liver fibrosis through SHP-1 upregulation." | 1.46 | Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. ( Chen, DS; Chen, KF; Chen, LJ; Chen, PJ; Hu, TC; Huang, KW; Huang, YJ; Jao, P; Kao, JH; Liu, CH; Liu, CJ; Shiau, CW; Su, TH; Tai, WT; Tseng, TC; Wu, YM; Yang, HC; Yang, NJ, 2017) |
| "However, possible splenic effects on liver fibrosis development are unclear." | 1.46 | Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice. ( Aoyama, T; Ikejima, K; Kokubu, S; Kon, K; Kuwahara-Arai, K; Miyazaki, A; Okubo, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| "Initiation and progression of liver fibrosis requires proliferation and activation of resting hepatic stellate cells (HSCs)." | 1.46 | Targeting CCl ( Bangen, JM; Baues, M; Haas, U; Hammerich, L; Lambertz, D; Lammers, T; Liedtke, C; Longerich, T; Sonntag, R; Tacke, F; Trautwein, C, 2017) |
| "Progressive liver fibrosis leads to cirrhosis and end-stage liver disease." | 1.46 | Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. ( Berardis, S; El Taghdouini, A; El-Kehdy, H; Evraerts, J; Henriet, P; Lombard, C; Najimi, M; Rosseels, V; Sokal, EM; van Grunsven, L, 2017) |
| "M2 macrophages were not effective on liver fibrosis." | 1.46 | Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. ( Bai, J; Dou, KF; Gao, CC; Han, H; Liang, SQ; Ma, PF; Qin, HY; Ye, YC; Yi, J; Zhao, JL; Zhao, Y; Zheng, QJ, 2017) |
| "Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks." | 1.46 | Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts. ( Chen, J; Hu, Y; Li, X; Liu, P; Liu, W; Mu, Y; Zhang, H; Zhou, Q, 2017) |
| "The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biological activities." | 1.46 | Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis. ( Fang, J; Qiu, M; Wang, L; Wang, Y; Zhang, Y, 2017) |
| "Previous studies indicated that cyanidin-3-O-β-glucoside (C3G) as a classical anthocyanin exerted an anti-fibrotic effect in the liver, but its bioavailability was quite low." | 1.46 | Cyanidin-3-O-β-glucoside combined with its metabolite protocatechuic acid attenuated the activation of mice hepatic stellate cells. ( Guo, H; Jiang, X; Ling, W; Shen, T; Tang, X; Yang, W, 2017) |
| "Detection of liver fibrosis during its earlier stages is a matter of great importance which may allow prevention of development of cirrhosis in patients with chronic liver disease." | 1.46 | Evaluation of liver fibrosis using Raman spectroscopy and infrared thermography: A pilot study. ( Escobedo, G; González, FJ; Guzmán, C; Kershenobich, D; Kolosovas-Machuca, ES; Ramírez-Elías, MG, 2017) |
| "Liver fibrosis is the response of liver diseases that puzzles patients." | 1.46 | MiR-29a and miR-652 Attenuate Liver Fibrosis by Inhibiting the Differentiation of CD4+ T Cells. ( Guo, SL; Huang, A; Shao, M; Wen, W; Xu, HB; Xuan, J; Yang, Y, 2017) |
| "Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type." | 1.46 | A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl ( Braeuning, A; Dooley, S; Hammad, S; Hengstler, JG; Meyer, C; Mohamed, FEZA, 2017) |
| "Liver fibrosis is a global health problem without approved treatment." | 1.46 | Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis. ( El-Hadidy, WF; El-Khatib, AS; El-Mezayen, NS; El-Refaie, WM; Khattab, MM; Shalaby, TI, 2017) |
| "Liver fibrosis is a common stage in the majority of chronic liver diseases, regardless of the etiology, and its progression may lead to hepatic cirrhosis or hepatocellular carcinoma." | 1.46 | Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride‑induced liver fibrosis using serum metabonomics based on gas chromatography‑time of flight mass spectrometry. ( Jiang, H; Li, WP; Li, ZQ; Ma, R; Qin, XJ; Wang, T, 2017) |
| "Effects of miR-9-5p on liver fibrosis in vivo and in vitro were analyzed." | 1.46 | Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2. ( Chen, B; Dong, P; Fan, X; Li, G; Yu, F; Zheng, J, 2017) |
| "Murine liver fibrosis was developed by CCI4 treatment three times per week over a 6-week period." | 1.46 | Xia-Yu-Xue Decoction Inhibits Intestinal Epithelial Cell Apoptosis in CCl4-Induced Liver Fibrosis. ( Liu, C; Ma, W; Tao, L; Xue, D; Zhang, J; Zhang, W; Zhu, Y, 2017) |
| "Liver fibrosis is a progressive pathological process resulting in an accumulation of excess extracellular matrix proteins." | 1.46 | Systemic inhibition of BMP1-3 decreases progression of CCl ( Bordukalo-Niksic, T; Brkljacic, J; Bubic-Spoljar, J; Dumic-Cule, I; Erjavec, I; Grgurevic, I; Grgurevic, L; Kufner, V; Matijasic, M; Novak, R; Paljetak, HC; Pauk, M; Plecko, M; Rogic, D; Verbanac, D; Vukicevic, S, 2017) |
| "During liver fibrosis, the increase in OPN induces HMGB1, which acts as a downstream alarmin driving collagen-I synthesis in HSCs." | 1.46 | Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury. ( Antoine, DJ; Arriazu, E; Ge, X; Kitamura, N; Leung, TM; Lopategi, A; Lu, Y; Magdaleno, F; Nieto, N; Theise, N; Urtasun, R, 2017) |
| "Elk-3 contributes to the progression of liver fibrosis by modulating the EMT via the regulation of Egr-1 under MAPK signaling." | 1.46 | Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. ( Choi, JE; Hong, SW; Hur, W; Kim, JH; Kim, SM; Lee, EB; Lee, JH; Li, TZ; Yoon, SK, 2017) |
| "Portal hypertension is a frequent pathological symptom occurring especially in hepatic fibrosis and cirrhosis." | 1.46 | Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction. ( Lu, C; Shao, J; Xu, W; Yao, S; Zhang, F; Zheng, S, 2017) |
| "Liver fibrosis is a progressive pathological process involving inflammation and extracellular matrix deposition." | 1.46 | The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. ( Bertolino, P; Chowdhury, S; Cordoba, SP; Evans, KA; Gall, MG; Gorrell, MD; Holz, LE; Jolly, CJ; Levy, MT; McCaughan, GW; Polak, N; Vieira de Ribeiro, AJ; Wang, XM; Yao, TW; Yu, DM; Zheng, YZ, 2017) |
| "Advanced liver fibrosis results in cirrhosis, liver failure and even hepatocellular cancer (HCC), often eventually requiring liver transplantation, poses a huge health burden on the global community." | 1.46 | Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis. ( Bu, F; Huang, C; Li, J; Li, W; Ma, T; Meng, X; Wu, Y; Yu, H; Zhang, L, 2017) |
| "However, the role of myricetin on liver fibrosis remains to be elucidated." | 1.46 | The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice. ( Geng, Y; Li, W; Lu, ZM; Shi, JS; Sun, Q; Xu, HY; Xu, ZH, 2017) |
| "There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents." | 1.46 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017) |
| "Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) in mice for 2 months (CCl4‑2M) or 3 months (CCl4‑3M)." | 1.46 | Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride. ( Gao, JH; Liu, R; Tang, CW; Tang, SH; Tong, H; Wen, SL; Yan, ZP, 2017) |
| "Rat models of liver fibrosis were made by carbon tetrachloride, and the serum levels of AST, ALT, γ-GT, MDA, GSH-px, SOD were detected, serum markers of PCⅢ, IV-C, LN, HA were detected by ELISA method." | 1.43 | [Research ontherapeutics effect of extract of Ornithogalum caudatum on liver fibrosis]. ( Gao, L; Jiang, WY; Qu, JL; Su, T; Zhang, M, 2016) |
| " In normal mice, the selected formula exhibited improved bioavailability and liver targeting efficiency compared to raw CUR." | 1.43 | Curcumin-Zein Nanospheres Improve Liver Targeting and Antifibrotic Activity of Curcumin in Carbon Tetrachloride-Induced Mice Liver Fibrosis. ( Abdallah, HM; Abdel-Naim, AB; Ahmed, OAA; Al-Sawahli, MM; Algandaby, MM; Ashour, OM; Fahmy, UA; Hattori, M, 2016) |
| "Pirfenidone has a protective role in improving the outcome of the liver fibrosis and it may become a new direction of early intervention in liver fibrosis." | 1.43 | [Effects of pirfenidone on hepatic fibrosis in mice induced by carbon tetrachloride]. ( Li, CX; Lv, JP; Qu, XH; Shi, Y; Xiao, M; Xie, KJ, 2016) |
| "Liver fibrosis was induced in rabbits by repetitive administration of carbon tetrachloride (CCl4 )." | 1.43 | Assessment of liver fibrosis by variable flip angle T1 mapping at 3.0T. ( Bai, W; Chen, L; Han, G; Hu, X; Huang, N; Li, Z; Sun, J; Yang, X; Zhou, Y, 2016) |
| "Sorafenib is a tyrosine kinase inhibitor that has recently been shown to be a potential antifibrotic agent." | 1.43 | Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis. ( Chen, Y; Chiang, T; Gao, DY; Lin, TsT; Liu, JY; Liu, YC; Sung, YC; Wan, D; Wang, L, 2016) |
| "To induce liver fibrosis, male Wistar rats received CCl4 (2 ml/kg/2 times/week; i." | 1.43 | Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways. ( Abd el Aziz, GM; El-Desouky, MA; Hasan, IH; Hozayen, WG, 2016) |
| "Liver fibrosis is a common outcome of chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma." | 1.43 | Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells. ( Byun, Y; Eom, H; Gao, B; Hahn, SK; Hamilton, JP; Hanes, J; Jeon, OC; Jo, DG; Kechrid, R; Kim, K; Kim, TH; Lee, CE; Lee, KC; Lee, S; Lim, SM; Mastorakos, P; Oh, Y; Park, JS; Park, O; Pomper, MG; Swierczewska, M; Zhang, C, 2016) |
| "Liver fibrosis was observed in CCl4 (800 ml/kg)-induced mice, and high viability was observed in CCl4 (10 mM)-intoxicated HSCs." | 1.43 | Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro. ( Bao, YF; Chu, X; Dong, YS; Guo, H; Jiang, YM; Luan, YC; Wang, H; Yang, F; Zhang, JP; Zhang, X; Zhang, YY, 2016) |
| "Liver cirrhosis is the common pathological histology manifest among a number of chronic liver diseases and liver cancer." | 1.43 | Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis. ( Cai, Y; Chen, Y; E, C; Li, J; Li, W; Liu, W; Pan, Y; Wu, Q; Zhang, X; Zheng, X, 2016) |
| "Melatonin was administered orally at 2." | 1.43 | Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. ( Hong, JM; Kang, JW; Lee, SM, 2016) |
| "Carbon tetrachloride (CCl4 ) was used to induce acute and chronic liver injury in TWEAK KO mice." | 1.43 | Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation. ( Adams, DH; Afford, SC; Amatucci, A; Burkly, LC; Hübscher, S; Humphreys, E; Munir, M; Resheq, Y; Reynolds, G; Shepherd, EL; Weston, CJ; Wilhelm, A, 2016) |
| "Liver fibrosis is one of the major causes of morbidity and mortality worldwide and lacks efficient therapy." | 1.43 | Cannabinoid receptors are involved in the protective effect of a novel curcumin derivative C66 against CCl4-induced liver fibrosis. ( Chen, DZ; Chen, RC; Chen, YP; Dong, JJ; Du, SJ; Feng, WK; Huang, SS; Liang, G; Wang, XD; Wu, H; Xu, LM; Yang, YP; Yu, ZP, 2016) |
| "Liver fibrosis was established in rats by the subcutaneous administration of 0." | 1.43 | Herbal medicine Gan‑fu‑kang downregulates Wnt/Ca2+ signaling to attenuate liver fibrogenesis in vitro and in vivo. ( Jia, Y; Jiang, M; Li, C; Li, H; Xu, T; Yang, G; Yuan, L; Zhang, C, 2016) |
| "The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known." | 1.43 | Inhibition of SIRT2 suppresses hepatic fibrosis. ( Arteaga, M; Breslin, P; Cotler, SJ; Denning, MF; Ding, X; Lüscher, B; Qiu, W; Shang, N; Shimamura, T; Yong, S, 2016) |
| "Liver fibrosis was induced by intraperitoneal injection of CCl4 three times a week for 10 weeks." | 1.43 | Glutamine inhibits CCl4 induced liver fibrosis in mice and TGF-β1 mediated epithelial-mesenchymal transition in mouse hepatocytes. ( Chand, L; Han, MK; Jeong, YJ; Kim, CY; Lee, SO; Shrestha, N, 2016) |
| "To evaluate the possible hepatoprotective effects of Jerusalem artichoke tubers (JAT) in combination with interferon and ribavirin." | 1.43 | Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. ( Abdel-Hamid, NM; Eisa, MA; Nazmy, MH; Wahid, A, 2016) |
| "The progression of liver fibrosis, an intrinsic response to chronic liver injury, is associated with hepatic hypoxia, angiogenesis, abnormal inflammation, and significant matrix deposition, leading to the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.43 | Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. ( Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH, 2016) |
| "Liver fibrosis was induced by intraperitoneal administration with CCl4." | 1.43 | Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance. ( Deng, WS; Gu, L; Sun, XF; Xu, Q; Zhou, H, 2016) |
| "Liver fibrosis is characterized by significant accumulation of extracellular matrix (ECM) proteins, mainly fibrillar collagen-I, as a result of persistent liver injury." | 1.43 | Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. ( Arriazu, E; Chen, Y; Conde de la Rosa, L; Ge, X; Magdaleno, F; Nieto, N; Ruiz de Galarreta, M, 2016) |
| "These results suggest that CCl₄ induces liver fibrosis by disrupting the metabolic pathways." | 1.43 | MicroRNA Expression Profiling in CCl₄-Induced Liver Fibrosis of Mus musculus. ( Hyun, J; Jung, Y; Kim, J; Lee, HH; Park, J; Seo, YS; Wang, S, 2016) |
| "Sprague-Dawley rats liver fibrosis was generated by 12-weeks treatment with CCl4 intraperitoneal injection." | 1.43 | MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R. ( Deng, ZY; Hu, W; Li, J; Liu, LP; Shi, P; Tao, H; Yang, JJ, 2016) |
| "Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in permanent liver damage." | 1.43 | Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. ( Harpavat, S; Kim, KH; Lee, JM; Moore, DD; Zhou, Y, 2016) |
| "Liver fibrosis is a consequence of chronic liver lesion, which can progress into liver cirrhosis even hepatocarcinoma." | 1.43 | Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis. ( Chen, QL; Dong, S; Hu, YY; Li, XY; Liu, P; Song, YN; Su, SB; Sun, Y; Wei, B, 2016) |
| "Here, we use experimental models of liver fibrosis to show that deficiency of the scavenger receptor, stabilin-1, exacerbates fibrosis and delays resolution during the recovery phase." | 1.43 | Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury. ( Adams, DH; Dawes, H; Elima, K; Gerke, H; Hübscher, SG; Jalkanen, S; Karikoski, M; Laurila, J; Ohlmeier, S; Patten, DA; Rantakari, P; Salmi, M; Shetty, S; Valtonen, J; Weston, CJ, 2016) |
| "Betaine (BET) has antioxidant, antiinflammatory and hepatoprotective effects." | 1.43 | High-fat diet plus carbon tetrachloride-induced liver fibrosis is alleviated by betaine treatment in rats. ( Aydın, AF; Başaran-Küçükgergin, C; Bingül, İ; Çoban, J; Doğan-Ekici, I; Doğru-Abbasoğlu, S; Uysal, M, 2016) |
| "Briefly, a rat model of liver fibrosis was created by administering intraperitoneal injections of CCl4." | 1.43 | Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro. ( Chi, C; Cui, LJ; Hou, F; Li, CY; Liu, RX; Liu, XY; Wen, Y; Yi, E; Yin, CH, 2016) |
| "Liver fibrosis is one of the leading causes of morbidity and mortality worldwide with very limited therapeutic options." | 1.43 | Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats. ( El-Agroudy, NN; El-Demerdash, E; El-Naga, RN; El-Razeq, RA, 2016) |
| "In vivo, liver fibrosis was induced by CCl4 twice a week for 10 weeks in mice." | 1.43 | Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo. ( Chen, ZH; Kuo, HC; Lee, KF; Lee, YJ; Lin, WL; Shen, CH; Shie, MS; Tseng, TH, 2016) |
| "Liver fibrosis is a global health problem and previous studies have demonstrated that reactive oxygen species (ROS) play important roles in fibrogenesis." | 1.43 | Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. ( Gao, Y; Gu, J; Kong, X; Sun, X; Wen, Y; Xia, Q; Yu, C; Yu, Y, 2016) |
| "Wnt/β-catenin pathway is involved in liver fibrosis and microRNAs (miRNAs) are considered as key regulators of the activation of hepatic stellate cells (HSCs)." | 1.43 | Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a. ( Chen, B; Dong, P; Fan, X; Yu, F; Zheng, J, 2016) |
| "This study shows that the progression of liver cirrhosis and the ameliorative effect of NTX can be followed through alterations of these markers." | 1.43 | Erythrocytes Membrane Alterations Reflecting Liver Damage in CCl₄-Induced Cirrhotic Rats: The Ameliorative Effect of Naltrexone. ( Bagherieh, M; Dehpour, AR; Doustimotlagh, AH; Golestani, A; Nourbakhsh, M; Sarhadi Kholari, F, 2016) |
| "DHA suppressed inflammation in rat liver fibrosis model and inhibited the expression of proinflammatory cytokines in activated hepatic stellate cells (HSCs)." | 1.43 | ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis. ( Guo, M; Shao, J; Zhang, Z; Zhao, S; Zheng, S, 2016) |
| "Liver fibrosis is the increasingly accumulation of extracellular matrix (ECM), caused by chronic liver injuries, and represents a difficult clinical challenge in the entire world." | 1.43 | Antifibrotic action of telmisartan in experimental carbon tetrachloride-induced liver fibrosis in Wistar rats. ( Badea, O; Bejenaru, C; Bejenaru, LE; ChiriŢă, C; Ionică, FE; Mogoantă, L; Negreş, S; Nicola, GC; Popescu, NL; Turculeanu, A, 2016) |
| "Melatonin was given at 5 or 10 mg/kg/d intraperitoneally, beginning 2 weeks after the start of CCl4 administration." | 1.42 | Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice. ( Crespo, I; Fernández, A; González-Gallego, J; Ortiz de Urbina, J; San-Miguel, B; Tuñón, MJ, 2015) |
| "Next, to elucidate the roles of Sfrp5 in liver fibrosis, we investigated a carbon-tetrachloride (CCl4 )-induced liver fibrosis model using Sfrp5 knockout (KO) and wild type (WT) mice in vivo." | 1.42 | Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis. ( Chatani, N; Egawa, M; Ezaki, H; Furuta, K; Hamano, M; Kamada, Y; Kiso, S; Kizu, T; Ogura, S; Ouchi, N; Shimono, A; Takehara, T; Yoshida, Y, 2015) |
| "In a mouse model of liver fibrosis, systemic injection of bone marrow mesenchymal stem cells (BM-MSCs) was considered to rescue the diseased phenotype." | 1.42 | Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis. ( Fujita, M; Ichinose, A; Ito, C; Matsuyama, A; Morita, M; Naba, K; Okura, H; Soeda, M, 2015) |
| "Next, we showed resolution of liver fibrosis by T-MSCs via reduction of TGF-β expression and collagen deposition in the liver." | 1.42 | Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation. ( Jeong, B; Jo, I; Jung, SC; Kim, HS; Kim, YH; Lee, H; Lee, HJ; Park, JW; Park, M; Park, YS; Ryu, KH; Woo, SY; Yu, Y, 2015) |
| "Liver fibrosis is a pathological condition in which chronic inflammation and changes to the extracellular matrix lead to alterations in hepatic tissue architecture and functional degradation of the liver." | 1.42 | Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. ( Bettaieb, A; Chiamvimonvat, N; Dong, H; Haj, FG; Hammock, BD; Harris, TR; Kodani, S; Myers, R, 2015) |
| " Microarray data of rat PCLS exposed to APAP andCCl4was generated using a toxic dose based on decrease in ATP levels." | 1.42 | Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices. ( Elferink, ML; Groothuis, GM; Olinga, P; Schoonen, WG; Vatakuti, S, 2015) |
| "Our findings suggest MLT may prevent liver fibrosis by inhibiting necroptosis-associated inflammatory signaling." | 1.42 | Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis. ( Choi, HS; Kang, JW; Lee, SM, 2015) |
| "CCl4-induced liver fibrosis protects mice against lethal dose of APAP, Possibly by a mechanism involving inhibition of the cytoplasmic translocation of HMGB1." | 1.42 | [Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury]. ( Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K, 2015) |
| "18α-GL is able to attenuate CCl4 induced liver fibrosis in rat." | 1.42 | Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis. ( Dong, Y; Lu, L; Qu, Y; Xu, M; Zong, L, 2015) |
| "Liver fibrosis was induced by intraperitoneal injections of carbon tetrachloride (CCl4) or bile duct ligation (BDL) for two weeks." | 1.42 | Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice. ( Choi, HS; Eun, HS; Jeong, WI; Jung, JY; Lee, YS; Park, KG; Park, SH; Suh, JM; Yi, HS, 2015) |
| "Different stages of liver fibrosis were induced in wild-type and NS3/4A-Tg mice by single carbon tetrachloride (acute) or multiple injections for 4 (intermediate) or 8 (chronic) weeks." | 1.42 | Hepatitis C Virus Nonstructural 3/4A Protein Dampens Inflammation and Contributes to Slow Fibrosis Progression during Chronic Fibrosis In Vivo. ( Bansal, R; Brenndörfer, ED; Frelin, L; Prakash, J; Sällberg, M; Storm, G, 2015) |
| "Liver fibrosis was induced by repeated intraperitoneal injection of carbon tetrachloride." | 1.42 | Macrophage autophagy protects against liver fibrosis in mice. ( Chobert, MN; Denaës, T; El-Benna, J; Lodder, J; Lotersztajn, S; Pawlotsky, JM; Teixeira-Clerc, F; Wan, J, 2015) |
| "Control rats were injected with saline." | 1.42 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats. ( Huang, W; Kong, X; Luo, S; Wang, ZJ; Zhang, LJ; Zhang, W, 2015) |
| "XYXD treatment reduced CCl4-induced liver fibrosis and decreased hepatic hydroxyproline (Hyp) content, the mRNA levels of smooth muscle actin (α-SMA) and Col 1(α1) in fibrotic liver." | 1.42 | Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways. ( Cheng, Z; Dai, X; Liu, C; Sheng, X; Tao, L; Xue, D; Yuan, X, 2015) |
| "Autophagy is a regulatory pathway in liver fibrosis." | 1.42 | Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. ( Chen, YH; Huang, WP; Hung, TM; Lai, HS; Lee, PH; Lin, CW; Lin, YC; Yuan, RH, 2015) |
| "The CCl4‑induced rats exhibited liver fibrosis, increased hydroxyproline content, impaired liver function, upregulated expression levels of the α‑SMA and TGF‑β1 pro‑fibrogenic proteins, and increased expression of HSP70, compared with the control group." | 1.42 | Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70. ( Chen, B; Chen, J; He, W; Qi, L; Shao, D; Wang, L; Wang, M; Zhuang, Y, 2015) |
| "Liver fibrosis was assessed histopathologically by Masson's trichrome staining and α-smooth muscle actin (α-SMA) immunostaining." | 1.42 | Hepatocyte Growth Factor Mediates the Antifibrogenic Action of Ocimum bacilicum Essential Oil against CCl4-Induced Liver Fibrosis in Rats. ( Abd-Elsalam, RM; El-Behairy, AM; El-Hindi, H; Eltablawy, NA; Ogaly, HA, 2015) |
| "Serum levels of Slit2 in patients with liver fibrosis were determined by ELISA." | 1.42 | Activation of Slit2-Robo1 signaling promotes liver fibrosis. ( Cao, L; Chang, J; Ding, Y; Gou, H; Gu, Q; Ji, X; Lan, T; Li, C; Li, J; Ou, Y; Qi, C; Qiao, L; Wang, L; Wen, D; Wu, T; Zhang, Q; Zheng, L, 2015) |
| "Phyllanthin was found to effectively bind to serine (Ser) 280 at the active site of ALK5 by forming hydrogen bonds." | 1.42 | Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice. ( Jyothilakshmi, V; Krithika, R; Prashantha, K; Verma, RJ, 2015) |
| "In the treatment group, liver fibrosis significantly decreased compared to the model group (P < 0." | 1.42 | Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats. ( Lv, HY; Wang, YL; Zhang, Q, 2015) |
| "Liver fibrosis is a feature in the majority of chronic liver diseases and oxidative stress is considered to be its main pathogenic mechanism." | 1.42 | Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats. ( Bi, XY; Fang, RT; Luo, AL; Ren, GX; Wei, XL; Yang, YH; Zang, WJ; Zhao, M, 2015) |
| "Liver fibrosis is the consequence of diverse liver injuries and can eventually develop into liver cirrhosis." | 1.42 | Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling. ( Peng, R; Wang, R; Wang, Y; Wu, Y; Yuan, Y, 2015) |
| "A histological assessment of the liver fibrosis was performed using stained liver samples." | 1.40 | Effects of the dihydrolipoyl histidinate zinc complex against carbon tetrachloride-induced hepatic fibrosis in rats. ( Inomata, M; Iwashita, Y; Kawano, Y; Kitano, S; Komori, Y; Ohta, M, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "The mouse liver fibrosis model was induced by carbon tetrachloride (CCl4)." | 1.40 | P2X7 blockade attenuates mouse liver fibrosis. ( Cui, H; Han, F; Huang, C; Huang, T; Wang, Y; Yu, W; Zhang, L, 2014) |
| "In the present study, liver fibrosis was induced in wild-type (WT), TLR7-deficient, and IFN-α/β receptor-1 (IFNAR1)-deficient mice and TLR7-mediated signaling was assessed in liver cells isolated from these mice." | 1.40 | Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. ( Kim, B; Kim, JW; Lim, CW; Park, S; Roh, YS; Seki, E, 2014) |
| "The progression of liver fibrosis in response to chronic injury varies considerably among individual patients." | 1.40 | Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population. ( Alberts, R; Böhm, M; Fischer, HP; Hall, RA; Hochrath, K; Kazakov, A; Lammert, F; Laufs, U; Liebe, R; Schughart, K; Weber, SN; Williams, RW, 2014) |
| "Th17/Treg imbalance exists in mice with liver fibrosis, which potentially promotes liver fibrosis via HSC activation." | 1.40 | Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice. ( Deng, WS; Gu, L; Sun, XF; Xu, Q, 2014) |
| "The mice model of liver fibrosis was induced by intraperitoneal injection of 50% (v/v) of carbon tetrachloride (CCl4) diluted in olive oil (1 ml/kg body weight) once every 2 days for 5 weeks." | 1.40 | Decorin prevents the development of CCl₄-induced liver fibrosis in mice. ( Cai, X; He, S; Liang, X; Liang, Y; Ma, R; Yu, H, 2014) |
| "XFZY inhibits liver fibrosis not only through inhibiting collagen deposition but also through an antiangiogenic effect on the fibrotic liver." | 1.40 | Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl₄ in mice. ( Chen, JM; Liu, P; Mu, YP; Ning, BB; Ren, S; Sun, MY; Yang, T; Zhou, YN, 2014) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 1.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "After 10 weeks, the model of liver fibrosis was formed." | 1.40 | [Therapeutic effect of BMSCs with over-expressed MMP1 on liver fibrosis]. ( Du, C; Jiang, M; Tang, S; Wei, X; Zeng, W; Zheng, S, 2014) |
| "The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process." | 1.40 | Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. ( Gao, X; Han, D; Jin, J; Li, F; Luo, S; Lv, G; Ma, N; Qiao, Y; Wang, L; Wu, G; Xiang, Y; Xu, C; Xu, Y; Yan, B; Zhang, Y; Zhao, R, 2014) |
| "Acanthoic acid might ameliorate liver fibrosis induced by CCl4 via LXRs signals." | 1.40 | Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals. ( Bai, T; Jin, Q; Jin, XJ; Li, Q; Lian, LH; Nan, JX; Wu, YL; Yang, N; Yao, YL, 2014) |
| "Patients with liver cirrhosis also have subtle cardiac structure or function abnormalities." | 1.40 | SHSST cyclodextrin complex prevents the fibrosis effect on CCl₄-induced cirrhotic cardiomyopathy in rats through TGF-β pathway inhibition effects. ( Chung, LC; Day, CH; Huang, CY; Ju, DT; Ting, WJ; Tsai, CH; Tsai, FJ; Tsai, Y; Yang, CH; Yeh, YL, 2014) |
| "Decursin treatment significantly reduced the ratio of liver/body weight, α-SMA activation, and type I collagen overexpression in CCl4 treated mice liver." | 1.40 | Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro. ( Choi, YJ; Chung, CH; Jeong, SI; Kim, DH; Kim, J; Kim, SJ; Kim, SY; Yu, KY, 2014) |
| "In 2 groups of SD rats, liver fibrosis was induced in experimental animals by repetitive carbon tetrachloride injections, while the control group received saline injections." | 1.40 | The hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and early liver cirrhosis in a rat model: an experimental study. ( Geng, X; Hao, L; Liu, A; Ma, C; Song, Q; Sun, B; Wang, H; Wang, Y; Zhao, G, 2014) |
| "Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use." | 1.40 | Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model. ( Chanderasekharan, H; Chheda, TK; Madanahalli, JR; Marikunte, VV; Moolemath, Y; Oommen, AM; Sadasivan, SK; Shivakumar, P, 2014) |
| "However, the role of TRPV4 in liver fibrosis is largely unknown." | 1.40 | TRPV4 channel inhibits TGF-β1-induced proliferation of hepatic stellate cells. ( Huang, C; Li, J; Ma, T; Meng, X; Song, Y; Yu, M; Zhan, L; Zhang, L, 2014) |
| "Advanced liver fibrosis results in cirrhosis and liver failure, and liver transplantation is often the only option for effective therapy; however, the shortage of available donor livers limits this treatment." | 1.40 | Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice. ( Chen, YH; Cheng, PJ; Cheng, WT; Chou, CJ; Kao, YJ; Ko, IC; Peng, SY; Shaw, SW; Wu, SC, 2014) |
| "The model of liver fibrosis was induced by intraperitoneal injection with CCl4 three times per week lasting for 12 weeks in CCl4 group and the BMP-7+CCl4 group." | 1.40 | BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor. ( Cao, ST; Chen, YP; Dong, JZ; Lin, Z; Shi, KQ; Wang, LP; Xiong, LJ; Zhang, SN; Zou, ZL, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "Hepatic cirrhosis was induced in Sprague-Dawley rats by subcutaneous injection of carbon tetrachloride and oral administration of alcohol." | 1.40 | [Gene expression profile changes induced upon umbilical cord mesenchymal cell infusion therapy in a rat model of hepatic cirrhosis]. ( Chi, L; Li, D; Liu, X; Ming, Y; Zang, C; Zhang, H, 2014) |
| "Liver fibrosis was induced in male Wistar rats by injecting a 50% CCl4/soybean oil solution subcutaneously twice a week for six weeks." | 1.40 | Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. ( Cheng, S; Li, H; Peng, Y; Shen, X; Song, H, 2014) |
| "Louis, MO) was fed for 3 weeks to induce liver fibrosis." | 1.40 | IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice. ( Gagea, M; Hunter, CA; Li, S; Mishra, L; Mitra, A; Satelli, A; Xueqing, X; Yan, J, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Acute hepatic injury and liver fibrosis in mice were induced by CCl4." | 1.40 | Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis. ( Liu, CH; Liu, ZL; Shen, L; Tao, YY; Yan, XC; Zhou, T, 2014) |
| "In this study, liver fibrosis was induced by CCl4 in treated rats." | 1.40 | Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1α through an ERK-dependent pathway. ( Gong, M; He, X; Hu, Y; Li, R; Luo, S; Ma, X; Wang, J; Wang, R; Xiao, X; Zhang, P; Zhao, Y, 2014) |
| "Sauchinone significantly inhibited liver fibrosis, as indicated by decreases in regions of hepatic degeneration, inflammatory cell infiltration, and the intensity of α-smooth muscle actin staining in mice." | 1.40 | Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. ( Jang, EJ; Kim, SC; Kim, YW; Ku, SK; Lee, JH; Lee, JR; Park, SD; Seo, HL; Shin, SS, 2014) |
| "Treatment with paeonol significantly protected the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, improving the histological architecture of the liver, and by inhibiting activation of hepatic stellate cells (HSCs) in vivo." | 1.39 | Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies. ( Chen, L; Kong, D; Lu, Y; Wei, D; Zhang, F; Zhang, X; Zheng, S; Zhu, X, 2013) |
| "Two models of rat liver fibrosis, the carbon tetrachloride and bile duct ligation models, were treated with rAAV/siRNA-TIMP-1." | 1.39 | Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis. ( Bai, Y; Chen, J; Cong, M; Cong, R; Fan, X; Jia, J; Li, H; Liu, T; Peng, Z; Tang, S; Tong, X; Wang, B; Wang, P; Wu, P; Yang, A; You, H, 2013) |
| "But the role of the GABAB receptor in liver fibrosis has never been reported." | 1.39 | Γ-aminobutyric acid B receptor improves carbon tetrachloride-induced liver fibrosis in rats. ( Fan, W; Feng, K; He, X; Ma, X; Shi, B; Wei, H, 2013) |
| "Bacterial peritonitis is a severe complication in patients with cirrhosis and ascites and despite antibiotic treatment, the inflammatory response to infection may induce renal dysfunction leading to death." | 1.39 | Modulation of inflammatory response in a cirrhotic rat model with induced bacterial peritonitis. ( Francés, R; González-Navajas, JM; Guarner, C; Mirelis, B; Muñoz, C; Pérez-Mateo, M; Sánchez, E; Sancho, FJ; Song, XY; Soriano, G; Such, J, 2013) |
| "Analysis of MSC and IL-6 treatment on liver fibrosis was measured by histopathology, PAS, TUNEL and Sirius red staining, RT-PCR, and liver function tests for Bilirubin and Alkaline Phosphatase (ALP)." | 1.39 | Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice. ( Ali, G; Khan, M; Khan, SN; Mohsin, S; Nasir, GA; Riazuddin, S; Shams, S, 2013) |
| "Sprague-Dawley rats were induced liver fibrosis by carbon tetrachloride (CCl4) for 10 weeks with or without BML-111, and the histopathology and collagen content were employed to quantify hepatic necro-inflammation and fibrosis." | 1.39 | BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats. ( Cai, ZY; Huang, YH; Min, WP; Sha, J; Wang, HM; Xu, FY; Yan, D; Yu, ZJ; Zhou, XY, 2013) |
| "In contrast, no change in liver fibrosis was observed in BDL-cirrhotic rats but an increase in the eNOS pathway." | 1.39 | Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats. ( Bosch, J; García-Calderó, H; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Tripathi, D, 2013) |
| "Liver fibrosis is the result of chronic liver injury, and it represents a widespread medical problem." | 1.39 | Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression. ( Blažeković, B; Domitrović, R; Jakovac, H; Marchesi, VV, 2013) |
| " The dose-response curve to norepinephrine in mesenteric arteriole was shifted to the right, and EC50 was significantly increased in cirrhotic patients and rats." | 1.39 | Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats. ( Chen, W; Huo, YM; Liu, DJ; Qin, J; Sang, JY; Wu, ZY; Xu, J, 2013) |
| "Tacrolimus (FK506) is a widely used immunosuppressive drug." | 1.39 | Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. ( Blackmon, J; Manojlovic, Z; Stefanovic, B, 2013) |
| "Here, we induced mouse liver fibrosis by ip injections of carbon tetrachloride (CCl4) or thioacetamide (TAA) and observed significant increase of hepatic GnT-V during the processes of liver fibrogenesis." | 1.39 | Knockdown of N-acetylglucosaminyl transferase V ameliorates hepatotoxin-induced liver fibrosis in mice. ( Chen, J; Dong, L; Liu, J; Tu, X; Zang, Y; Zhang, H; Zhang, J; Zhang, Z; Zhu, J, 2013) |
| "Deletion of CCL3 exhibited reduced liver fibrosis compared to their wild-type counterparts." | 1.39 | The chemokine CCL3 promotes experimental liver fibrosis in mice. ( Berres, ML; Fischer, P; Heinrichs, D; Nellen, A; Sahin, H; Scholten, D; Trautwein, C; Wasmuth, HE, 2013) |
| "IFN-α can inhibit liver fibrosis following 6 weeks of middle-dose IFN-α therapy by upregulating CD4(+)CD25(+)Foxp3(+) Tregs and suppressing CD8(+) T cells." | 1.39 | CD4+CD25+Foxp3+ regulatory T cells contribute in liver fibrosis improvement with interferon alpha. ( Cao, YM; Feng, L; Kang, H; Liu, LN, 2013) |
| "The gold standard in assessing liver fibrosis is biopsy despite limitations like invasiveness and sampling error and complications including morbidity and mortality." | 1.39 | Molecular MRI of collagen to diagnose and stage liver fibrosis. ( Caravan, P; Fuchs, BC; Lauwers, GY; Parkar, A; Polasek, M; Schühle, DT; Sinskey, AJ; Tanabe, KK; Wang, H; Wei, L; Yang, Y, 2013) |
| "To induce liver fibrosis in this model, rats were given a subcutaneous injection of a 40% solution of CCl4 in olive oil at a dose of 0." | 1.39 | Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathway. ( Cao, Q; Fan, FG; Guo, XL; Jin, J; Jin, L; Lan, R; Liang, B; Wang, XC; Wang, XW; Yang, JH, 2013) |
| "Liver fibrosis was induced in male Sprague-Dawley (SD) rats by the subcutaneous injection of CCl4." | 1.39 | Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats. ( He, Y; Huang, S; Liu, W; Wu, F; Zhang, Y; Zhu, N, 2013) |
| "CCl4-induced liver fibrosis was rarely detected in Smad3-/- mice compared to Smad3+/+." | 1.39 | Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein. ( Goo, MJ; Hong, IH; Hwang, M; Ishigami, A; Jeong, DH; Jeong, KS; Ki, MR; Kim, AY; Lee, EJ; Lee, EM; Park, JK, 2013) |
| "Regression of liver fibrosis occurred by reducing myofibroblasts (through modulation of HSCs activation mechanisms), remodelling extracellular matrix (through increase of its degradation) and regenerating liver tissue and functions: three processes regulated by fine mechanisms where active TGF-β1 and tTG play a central role." | 1.39 | Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1. ( Caporaso, N; D'Argenio, G; Fogliano, V; Guarino, M; Lembo, V; Mazzone, G; Morisco, F; Napolitano, M; Ribecco, MT; Vitaglione, P, 2013) |
| "Liver fibrosis was induced in male C57BL/6N mice by injecting a 10% CCl(4) solution intraperitoneal twice a week for six weeks." | 1.39 | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. ( Chen, M; Cheng, Q; Huang, C; Li, N; Li, Q; Lin, Q; Qian, Z; Shi, G; Wang, X; Zheng, J, 2013) |
| "Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities." | 1.39 | Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. ( Dang, X; Dong, L; Jia, M; Jiang, J; Lu, X; Shi, H; Zhao, G; Zhao, J, 2013) |
| "Using two liver cirrhosis mouse models induced by CCl4 or thioacetamide, we showed that targeting AR in the BM-MSCs improved their self-renewal and migration potentials and increased paracrine effects to exert anti-inflammatory and anti-fibrotic actions to enhance liver repair." | 1.39 | Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis. ( Chang, C; Huang, CK; Lai, KP; Lee, SO; Lin, TH; Luo, J; Ma, WL; Tsai, MY, 2013) |
| " Hepatic endothelial function was assessed in isolated and perfused rat livers by dose-response curves to acetylcholine (ACh) and methoxamine (Mtx)." | 1.39 | Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats. ( Abrante, B; Abreu, P; de Ganzo, ZA; Felipe, V; González-Méndez, Y; Hernández-Guerra, M; Moreno, M; Quintero, E; Salido, E, 2013) |
| "The results showed that serum albumin, liver fibrosis and liver function were significantly improved in the group treated with cultured bone marrow cells (P<0." | 1.39 | Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice. ( Hisanaga, T; Iwamoto, T; Sakaida, I; Takami, T; Terai, S; Watanabe, S; Yamamoto, N, 2013) |
| " Moreover, we evaluated endothelial function by dose-relaxation curves to acetylcholine, hepatic NO bioavailability and TXA2 production." | 1.39 | Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; Di Pascoli, M; Diví, M; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Vilaseca, M, 2013) |
| "Liver fibrosis was induced in 52 male Wistar rats by inhalation of carbon tetrachloride and the level of hepatic fibrosis was assessed by Sirius red staining compared with controls." | 1.39 | Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis--a serological evaluation. ( Byrjalsen, I; Christiansen, C; Jiménez, W; Karsdal, MA; Leeming, DJ, 2013) |
| "FHL2(-/-) mice displayed aggravated liver fibrosis compared to wt mice." | 1.39 | Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. ( Adam, AC; Büttner, R; Goltz, D; Huss, S; Khlistunova, I; Kirfel, J; Stellmacher, C; Trebicka, J; Weiskirchen, R, 2013) |
| "However, its role in alcoholic liver fibrosis has not been fully clarified." | 1.39 | Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. ( Di, HL; Du, JH; Kong, LB; Li, WC; Li, Y; Nan, YM; Ren, WG; Wang, RQ; Wu, WJ; Yu, J; Zhang, YG; Zhao, SX, 2013) |
| "CD34(+) cell transplantation reduced liver fibrosis in a dose-dependent fashion, with decreased collagen type-I and α-SMA-positive cells after 6 weeks of CCl(4) treatment by Mallory's Azan and immunohistochemical staining." | 1.38 | Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats. ( Abe, M; Asahara, T; Hashimoto, O; Ii, M; Iwamoto, H; Kawamoto, A; Koga, H; Masuda, H; Naitou, M; Nakamura, T; Sata, M; Torimura, T; Tsutsumi, V; Ueno, T, 2012) |
| "Azelnidipine is a calcium blocker that has been shown to have antioxidant effects in endothelial cells and cardiomyocytes." | 1.38 | Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. ( Horiguchi, N; Ichikawa, T; Izumi, T; Kakizaki, S; Kishimoto, K; Mori, M; Ohyama, T; Sato, K; Takagi, H; Yamazaki, Y, 2012) |
| "A key feature in the pathogenesis of liver fibrosis is fibrillar Collagen-I deposition; yet, mediators that could be key therapeutic targets remain elusive." | 1.38 | Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. ( Fiel, MI; Ge, X; George, J; Leung, TM; Lopategi, A; Lu, Y; Nieto, N; Urtasun, R; Wang, X, 2012) |
| "Liver fibrosis is a major health problem that can lead to the development of liver cirrhosis and hepatocellular carcinoma." | 1.38 | Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats. ( Abdalla, AM; Abdelwahab, SA; Mahmoud, AM; Mahmoud, ME; Morsy, MA, 2012) |
| "Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ." | 1.38 | A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. ( Ebinuma, H; Hibi, T; Hiroi, S; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Miura, S; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Sugiyama, K; Suzuki, T; Teratani, T; Tominaga, S; Tomita, K; Yokoyama, H, 2012) |
| "Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia." | 1.38 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. ( Beisner, J; Bevins, CL; Hofmann, C; Nuding, S; Schoelmerich, J; Stange, EF; Teltschik, Z; Wehkamp, J; Wiest, R, 2012) |
| "Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process." | 1.38 | Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. ( Fiel, MI; Ge, X; Lu, Y; Mormone, E; Nieto, N, 2012) |
| "The development of liver fibrosis from chronic inflammation can involve epithelial-mesenchymal transition (EMT)." | 1.38 | Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice. ( Jeong, SJ; Kang, M; Kim, HJ; Kim, SH; Lee, HJ; Lee, JW; Park, KH; Park, SY; Ye, SK, 2012) |
| "The rat liver fibrosis model was induced by carbon tetrachloride (CCl4)." | 1.38 | 18α-Glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells. ( Chen, WH; Lu, LG; Qu, Y; Xu, MY; Zong, L, 2012) |
| " Nitric oxide (NO) bioavailability and eNOS activation were measured in hepatic endothelial cells (HEC) isolated from cirrhotic rat livers." | 1.38 | PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; García-Calderó, H; García-Pagán, JC; Laviña, B; Rodríguez-Vilarrupla, A; Roglans, N; Rosado, E; Russo, L, 2012) |
| "The progression of liver fibrosis results in hepatocellular carcinogenesis in later stages." | 1.38 | Global analysis of DNA methylation in early-stage liver fibrosis. ( Iwasaki, N; Komatsu, Y; Ono, W; Waku, T; Yamaguchi, C; Yanagisawa, J, 2012) |
| "A CCl(4)-induced liver fibrosis model in mice was also utilized." | 1.38 | C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo. ( Chen, Q; Cheng, YY; Deng, L; Ding, D; Li, QQ; Liu, XP; Mei, S; Ou-Yang, Q; Tao, LL; Xu, JW; Xu, ZD; Yu, J, 2012) |
| "TAA induced liver fibrosis in both HB-EGF(+/+) and HB-EGF(-/-) mice." | 1.38 | Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. ( Besner, GE; Brigstock, DR; Huang, G, 2012) |
| "Liver fibrosis is a major cause of liver failure, but treatment remains ineffective." | 1.38 | Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro. ( He, RH; Huang, XR; Lan, HY; Meng, XM; Tan, JJ; Tang, LX; Yang, G; Zhou, L, 2012) |
| "Curcumin is a natural product with antifibrotic effects, but has poor pharmacokinetic profiles." | 1.38 | Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats. ( Chen, WX; Kong, DS; Lu, Y; Ma, J; Ni, CY; Ni, GX; Wang, AY; Zhang, F; Zhang, XJ; Zhang, XP; Zheng, SZ, 2012) |
| "The rat model of liver fibrosis was induced by subcutaneous injection of 40% (v/v) of CCl₄ diluted in olive oil (3 mL/kg body weight) twice per week for 8 weeks." | 1.38 | Polyprenols from Taxus chinensis var. mairei prevent the development of CCl₄-induced liver fibrosis in rats. ( Fu, C; Liu, B; Qian, H; Wang, Y; Yu, J; Zhao, Y, 2012) |
| "In a carbon tetrachloride-treated mouse model, SphK1 was expressed in BMSCs in damaged liver." | 1.38 | Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-β1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis. ( Chang, N; Han, Z; Li, C; Li, L; Liu, X; Yang, L; Zhu, T, 2012) |
| "Molecular MRI of liver fibrosis with a collagen-specific probe identifies fibrotic tissue in two rodent models of disease." | 1.38 | Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. ( Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S, 2012) |
| "Treatment with curcumin significantly attenuated CCl(4)-induce liver injury, hepatic inflammation and reduced the levels of proinflammatory mediators (TNF-α, IL-6 and MCP-1)." | 1.38 | Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. ( Tu, CT; Wang, JY; Xu, BL; Yao, QY; Zhang, SC; Zhou, CH, 2012) |
| "The rat liver fibrosis model was produced by intraperitoneal injection of carbon tetrachloride for assessing the effects of Fsp27 in the rat liver." | 1.38 | Inhibition of hepatic stellate cell activation and liver fibrosis by fat-specific protein 27. ( Ji, S; Su, L; Yu, F; Yu, P; Zhang, Q; Zhang, S; Zheng, Y, 2012) |
| "• Liver MR T1ρ decreased when liver fibrosis and injury regressed." | 1.38 | MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication. ( Ahuja, AT; Chu, ES; Deng, M; Go, MY; Teng, GJ; Wang, YX; Wong, HL; Yu, J; Yuan, J; Zhao, F, 2012) |
| " We previously reported that acupuncture combined with curcumin, a natural antifibrotic compound, could remarkably attenuate liver fibrosis in chemically intoxicated rats, but the underlying molecular mechanisms are poorly understood." | 1.38 | Acupuncture combined with curcumin disrupts platelet-derived growth factor β receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats. ( Chen, WX; Kong, DS; Lu, Y; Ma, J; Ni, GX; Wang, AY; Zhang, F; Zhang, XP; Zhang, ZL; Zheng, SZ, 2012) |
| "In the experimental group, liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride." | 1.38 | Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: an animal study. ( Huang, YP; Lau, TY; Lee, ES; Leung, G; Tipoe, GL; Ying, M; Yuen, QW; Zheng, YP, 2012) |
| "In mouse liver fibrosis model, HAb18G/CD147 expression increased with the development of fibrogenesis and decreased during the liver fibrosis spontaneous recovery." | 1.38 | HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis. ( Bian, H; Chen, C; Chen, ZN; Gong, L; Han, Y; Li, YL; Tang, H; Wei, D; Wu, J; Xu, J; Zhang, DW; Zhang, W; Zhang, Y; Zhao, YX, 2012) |
| "Rats treated with curcumin improved liver necro-inflammation, and reduced liver fibrosis in association with decreased α-smooth muscle actin expression, and decreased collagen deposition." | 1.38 | Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. ( Liu, HC; Tu, CT; Wang, JY; Xu, BL; Yao, QY; Zhang, SC, 2012) |
| "The hydroxyproline (HYP) content was detected by acid hydrolysis method." | 1.38 | [Comparison of effect of formulas clearing away heat and promoting blood circulation on prevention and treatment of liver fibrosis in CCl4 mice]. ( Liu, C; Liu, P; Peng, Y; Ren, H; Tao, Y; Wang, Z; Yu, H; Zhao, Z; Zhu, B, 2012) |
| " Chronic administration of aliskiren, a newly developed direct renin inhibitor, decreases Ang II in the hypertensive patients and animals." | 1.38 | Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice. ( Chan, CC; Hsieh, YC; Huang, YH; Lee, KC; Lin, HC; Yang, YY, 2012) |
| "Thymosin β4 (Tβ4) plays a role in fibrosis, inflammation, and in the reparative process of injured cells and tissues." | 1.38 | Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats. ( Arellanes-Robledo, J; Lakshman, MR; Reyes-Gordillo, K; Rojkind, M; Shah, R, 2012) |
| " To induce different stages of liver fibrosis, a sufficient number of male Wistar rats were differentially exposed to chronic administration with carbon tetrachloride." | 1.38 | In vivo assessment of liver fibrosis using diffuse reflectance and fluorescence spectroscopy: a proof of concept. ( Acevedo-García, C; Aguirre-García, J; de la Rosa, JM; Escobedo, G; Fabila, D; Guzmán, C; Kershenobich, D; López-Navarrete, G; Moreno, E; Stolik, S; Suárez-Álvarez, K, 2012) |
| "Curcumin was significantly returned the expression levels of mir-199 and -200 with their associated target gene nearly to their normal levels." | 1.38 | Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis. ( Al-Olayan, EM; Hassan, ZK, 2012) |
| "Following chronic CCl(4) administration, liver fibrosis was analyzed using Sirius Red staining with quantitative morphometry and real-time polymerase chain reaction (PCR) in MMP-2-/- mice and age-matched MMP-2+/+ controls." | 1.37 | Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression. ( Alvarez, CE; Bansal, MB; Bowles, R; DiFeo, A; Friedman, SL; Gupta, R; Martignetti, JA; Narla, G; Radbill, BD; Ramirez, MC; Saiman, Y; Vrabie, R, 2011) |
| "Liver samples from patients with liver fibrosis and from mice treated by either carbon tetrachloride (CCl(4)) or thioacetamide (TAA) were evaluated for mRNA expression of Snail1." | 1.37 | Snail1 transcription factor is a critical mediator of hepatic stellate cell activation following hepatic injury. ( Brun, P; Buda, A; Castagliuolo, I; De Caro, R; Fabris, P; Giordani, MT; Grillo, AR; Macchi, V; Martines, D; Palù, G; Scarpa, M; Signori, S; Stefani, A, 2011) |
| "In the CCl(4)-induced liver fibrosis model, systemic administration of pMMP13 using HA and polyethylenimine (PEI) significantly increased the expression of MMP13 and reduced collagen deposition." | 1.37 | Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid. ( Cho, HJ; Kim, EJ; Kim, JY; Kim, YB; Oh, YK; Park, D; Park, TG; Shim, CK, 2011) |
| "Chronic hepatic injury results in liver fibrosis with eventual progression to irreversible cirrhosis." | 1.37 | Texture analysis of liver fibrosis microscopic images: a study on the effect of biomarkers. ( Amin, A; Mahmoud-Ghoneim, D, 2011) |
| " Advanced liver fibrosis was induced in female mice by chronic administration of carbon tetrachloride." | 1.37 | Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. ( Forbes, SJ; Gordon-Walker, TT; Hartland, S; Hume, DA; Iredale, JP; Pope, C; Ramachandran, P; Robson, AJ; Thomas, JA; Van Deemter, M; Wojtacha, D, 2011) |
| "Hydroxysafflor yellow A (HSYA) was isolated from the dried flower of Carthamus tinctorius L." | 1.37 | Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis. ( Dong, H; Guo, J; Li, X; Liu, J; Niu, Y; Zhang, Y; Zhao, X; Zhou, L, 2011) |
| " To address this issue, we induced liver fibrosis by carbon tetrachloride (CCl(4)) chronic administration to 8-week- and 15-month-old mice." | 1.37 | Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response. ( Abdoun, E; Collin de l'Hortet, A; Cosson, C; Fromenty, B; Gilgenkrantz, H; Guidotti, JE; Mahrouf-Yorgov, M; Mitchell, C; Slama, A, 2011) |
| "Oxidative stress is related to the liver fibrosis, anticipating the hepatic stellate cells' (HSC) activation." | 1.37 | Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis. ( Catoi, C; Clichici, S; Daicoviciu, D; Decea, N; Filip, A; Gherman, C; Login, C; Mocan, T; Moldovan, R; Muresan, A; Nagy, A, 2011) |
| "Since Sept4(-/-)mice are prone to liver fibrosis, we aimed to identify the unknown molecular network underlying liver fibrosis by probing the association between loss of Sept4 and accelerated transdifferentiation of HSCs." | 1.37 | Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells. ( Asechi, H; Hatano, E; Iwaisako, K; Kinoshita, M; Nagata, H; Narita, M; Sato, F; Taura, K; Uemoto, S; Yanagida, A, 2011) |
| "Using a mouse liver fibrosis model, we show that carbon tetrachloride treatment induces ADAMTS1 expression in parallel to that of type I collagen." | 1.37 | Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta. ( Baffet, G; Bonnier, D; Bourd-Boittin, K; Ezan, F; Leyme, A; Mari, B; Samson, M; Theret, N; Tuffery, P, 2011) |
| "In the fibrosis group, experimental liver fibrosis was induced by subcutaneous injection of carbon tetrachloride (CCl4 soluted in oil with the concentration of 500 mL/L)." | 1.37 | [The effects of prolonged sevoflurane anesthesia on renal function in liver fibrosis rabbits]. ( Fang, DF; Li, Y; Yang, AM; Yin, Y; Zhang, WY, 2011) |
| " However, some herbs, such as rhubarb, have been documented as having both therapeutic and toxic effects on the liver, leading to the complex problem of distinguishing the benefits from the risks of using this herb." | 1.37 | Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. ( Fang, F; Jin, C; Kong, WJ; Liu, DJ; Wang, HJ; Wang, JB; Xiao, XH; Zhang, L; Zhao, HP; Zhao, YL, 2011) |
| "The marker was highly associated with liver fibrosis in two liver fibrosis animal models, suggesting type VI turnover to be a central player in fibrogenesis." | 1.37 | MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay. ( Hägglund, P; Karsdal, MA; Larsen, MR; Leeming, DJ; Luo, Y; Nawrocki, A; Nguyen, QH; Vainer, B; Vassiliadis, E; Veidal, SS; Zheng, Q, 2011) |
| "Experimental liver fibrosis was induced by subcutaneous injection of CCl4." | 1.37 | [Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats]. ( Bao, JF; Shi, JP; Xu, S, 2011) |
| "Liver fibrosis is regulated by an epigenetic relay pathway that includes MeCP2, EZH2, and miR132." | 1.36 | MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. ( Chu, DC; Mann, DA; Mann, J; Maxwell, A; Oakley, F; Tsukamoto, H; Zhu, NL, 2010) |
| "Since liver fibrosis frequently occurs before hepatoma development, this study investigated the expression profile of HDGF and its relationship with transforming growth factor-beta (TGF-beta) signaling in experimental models of hepatofibrogenesis." | 1.36 | Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis. ( Chan, HH; Chao, D; Chen, CL; Cheng, KH; Cheng, YF; Chung, YH; Goto, S; Hu, TH; Jawan, B; Kao, YH; Kuo, SM; Lin, YC; Sun, CK; Tai, MH; Wu, DC, 2010) |
| "Treatment with cystamine and garlic extract reduced the liver fibrosis and collagen deposition, particularly in the garlic extract group (p<0." | 1.36 | Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase. ( Amoruso, DC; Caporaso, N; D'Argenio, G; D'Armiento, MR; Fogliano, V; Mazzone, G; Mezza, E; Morisco, F; Ribecco, MT; Romano, A; Vitaglione, P, 2010) |
| "Baicalein treatment (20, 40, or 80 mg/kg for 10 weeks) dose-dependently decreased levels of these markers." | 1.36 | Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. ( Che, QM; Pu, XP; Sun, H; Zhao, X, 2010) |
| "MSCs caused a decrease in liver fibrosis histopathologically, 4 weeks after transplantation." | 1.36 | Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. ( Azhdari, Z; Baharvand, H; Gharavi, M; Piryaei, A; Rabani, V; Shahsavani, M, 2010) |
| "To induce liver fibrosis, male Wistar rats were injected carbon tetrachloride (CCl(4)) intraperitoneally (2." | 1.36 | Treatment with L-valine ameliorates liver fibrosis and restores thrombopoiesis in rats exposed to carbon tetrachloride. ( Doi, H; Katsura, K; Nakanishi, C; Satomi, S, 2010) |
| "Liver fibrosis was induced in rats by subcutaneous injection of CCl(4) and a high-lipid/low-protein diet for 8 wk (except the control group)." | 1.36 | Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. ( Cheng, ML; Mu, M; Wang, YP; Wu, J; Zhang, BF, 2010) |
| "Glycogen was decreased by CCl(4), while celecoxib partially prevented and reversed this effect." | 1.36 | Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat. ( Castro-Sánchez, L; Chávez, E; Moreno, MG; Muriel, P; Salazar, EP; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2010) |
| "All mice developed liver fibrosis." | 1.36 | Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. ( Brenner, DA; Gu, G; Iwaisako, K; Kisseleva, T; Osterreicher, CH; Scholten, A; Scholten, D, 2010) |
| "Carbon tetrachloride (CCl(4))-treated mouse model in vivo and in hepatic stellate cells (HSC) in vitro were used." | 1.36 | Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production. ( Hu, LH; Li, CJ; Liu, Q; Shen, X; Wang, X; Zhang, Y, 2010) |
| "Marimastat-treated animals demonstrated significantly attenuated liver injury and inflammation but a 25% increase in collagen deposition." | 1.36 | Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. ( de Meijer, VE; Le, HD; Meisel, JA; Nosé, V; Popov, Y; Puder, M; Schuppan, D; Sverdlov, DY, 2010) |
| "Taken together, VNP ameliorates liver fibrosis by inhibiting collagen production from hepatic stellate cells via guanylyl cyclase-coupled NPR/cGMP/PKG pathway, indicating that VNP might be a new effective reagent in the treatment of liver fibrosis." | 1.36 | Protecting effects of vasonatrin peptide against carbon tetrachloride-induced liver fibrosis. ( Chen, BY; Qu, P; Tie, R; Yu, J; Zhu, MZ; Zhu, XX, 2010) |
| "We postulated that, in liver fibrosis, a reversal of LSEC function from tolerogenic to proinflammatory and immunogenic may contribute to both the heightened inflammatory milieu and altered intrahepatic immunity." | 1.36 | In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. ( Bedrosian, AS; Cieza-Rubio, NE; Cohen, S; Connolly, MK; Frey, AB; Hassan, BU; Henning, JR; Ibrahim, J; Malhotra, A; Miller, G; Pachter, HL; Vera, V, 2010) |
| " The pharmacokinetic parameters were estimated using previously developed barrier-limited and space-distributed models." | 1.36 | Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model. ( Asadian, P; Crawford, DH; Fletcher, LM; Khlentzos, AM; Li, P; Liu, X; Roberts, MS; Robertson, TA; Thorling, CA; Zou, YH, 2010) |
| "Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment." | 1.36 | Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. ( Hu, Y; Jian, P; Liu, C; Liu, P; Peng, J; Sun, M; Tao, Q; Wu, JZ; Yang, W, 2010) |
| "To induce liver fibrosis, C57BL6 female mice were injected i." | 1.35 | Platelets contribute to the reduction of liver fibrosis in mice. ( Aoyagi, Y; Fukunaga, K; Hashimoto, I; Ikeda, O; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N; Watanabe, M; Yasue, H, 2009) |
| "Methyl palmitate (MP) is an effective Kupffer cell inhibitor." | 1.35 | Methyl palmitate prevents CCl(4)-induced liver fibrosis. ( Galicia-Moreno, M; Moreno, MG; Muriel, P; Reyes-Gordillo, K; Rodríguez-Rivera, A; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| "To this end, liver fibrosis was induced in AR+/+ and AR-/- mice by chronic CCl(4) administration." | 1.35 | The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. ( Avila, MA; Berasain, C; Cartagena-Lirola, H; Castillo, J; Goñi, S; Latasa, MU; Lotersztajn, S; Nicou, A; Perugorria, MJ; Prieto, J; Vespasiani-Gentilucci, U; Zagami, MG, 2008) |
| "Taurine treatment reduced fibrosis scores significantly as compared to placebo." | 1.35 | Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury. ( Comert, B; Mas, MR; Mas, N; Tasci, I; Tuncer, M, 2008) |
| "In a carbon-tetrachloride-induced liver fibrosis rat model, analysis of urine by 2-DGE revealed an increase in the concentration of a number of proteins in animals with hepatic fibrosis." | 1.35 | Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat. ( Ashiq, R; Clarke, CJ; Dare, TO; Griffiths, W; Lane, CS; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2009) |
| "Carbon tetrachloride (CCl(4)) was given orally to rats twice a week for 8 weeks." | 1.35 | Lipid peroxidation products do not activate hepatic stellate cells. ( Fang, HL; Lin, WC, 2008) |
| " The circulating levels of apelin, the messenger RNA (mRNA) and protein expression of apelin and apelin receptor, the immunohistological detection of apelin and apelin receptor, and the effects induced by the chronic administration of an apelin receptor antagonist on fibrosis and vessel density were evaluated in rats with cirrhosis and ascites and in control rats." | 1.35 | The hepatic apelin system: a new therapeutic target for liver disease. ( Arroyo, V; Bernardi, M; del Arbol, LR; Fernández-Varo, G; Jiménez, W; Melgar-Lesmes, P; Morales-Ruiz, M; Principe, A; Ros, J, 2008) |
| "In both acute hepatotoxicity and liver fibrosis, serum aminotransferase levels and lipid peroxidation were increased and the hepatic glutathione content was decreased." | 1.35 | Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis. ( Cheon, HJ; Kim, SH; Lee, SM; Oh, ST; Shim, KS; Shin, E; Yun, N, 2009) |
| "Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always associated with inflammation that contributes to fibrogenesis." | 1.35 | Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. ( Gao, B; Gershwin, ME; Jeong, WI; Lian, ZX; Park, O; Wang, H; Wang, L, 2009) |
| "Liver fibrosis was induced by carbon tetrachloride (CCl(4)) injection in rats for 5 weeks." | 1.35 | Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats. ( Chan, KK; Chor, JS; Go, YY; Sung, JJ; Yu, J, 2009) |
| "Anisodamine can inhibit hepatic fibrosis." | 1.35 | Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-in ( Luo, L; Zhou, A, 2009) |
| "The development of CCl4-induced acute liver failure altered the redox state with a decreased hepatic GSH and increased formation of lipid peroxidative products, which were partially normalized by treatment with heparin-SOD or heparin + SOD." | 1.35 | The preventive effects of heparin-superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice. ( Cao, J; Liu, J; Sun, Y; Tan, H; Wang, F; Zhou, S, 2009) |
| "CXCR3(-/-) mice had increased liver fibrosis; progression was associated with decreased numbers of intrahepatic interferon gamma-positive T cells and reduced interferon gamma messenger RNA, indicating that CXCL9-CXCR3 regulates Th1-associated immune pathways." | 1.35 | Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. ( Berg, T; Berres, ML; Dahl, E; Friedman, SL; Gassler, N; Hellerbrand, C; Hillebrandt, S; Keppeler, H; Lammert, F; Schmitz, P; Scholten, D; Streetz, KL; Tacke, F; Trautwein, C; Wasmuth, HE; Weiskirchen, R; Zaldivar, MM; Zimmermann, H, 2009) |
| "2." | 1.35 | Pirfenidone inhibits carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents by preventing activation of hepatic stellate cells. ( Li, XM; Wang, BE; Wang, TL; Zeng, X; Zhao, XY, 2009) |
| "The specific purpose of this study was to investigate the effects of dietary olive oil on hepatic fibrosis induced by chronic administration of carbon tetrachloride (CCl(4)) in the mouse." | 1.35 | Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice. ( Fujii, H; Hosomura, N; Ishii, K; Kono, H; Tanaka, N, 2009) |
| "Portal hypertension is triggered by vasodilation due to impaired contraction of extrahepatic vessels." | 1.35 | Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. ( Heller, J; Hennenberg, M; Kohistani, AZ; Sauerbruch, T; Trebicka, J, 2009) |
| "Rats were divided into control, liver fibrosis, high, medium, and low dose curcumin (200, 100, and 50 mg kg(-1), respectively), and colchicine (0." | 1.35 | Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. ( He, YJ; Lv, X; Shu, JC; Wang, LX; Ye, GR, 2009) |
| "Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM)." | 1.35 | Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis. ( Jo, JH; Kim, KH; Kim, SJ; Lee, WR; Park, JB; Park, JH; Park, KK, 2009) |
| "There existed obvious liver fibrosis in liver tissues in the untreated group as compared with the blank group (P<0." | 1.35 | [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. ( Chen, JM; Ji, G; Liu, T; Wang, L; Xing, LJ; Zheng, PY, 2009) |
| "Liver index and the degree of liver fibrosis were also determined." | 1.35 | Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. ( Chen, LJ; Dai, LL; He, CM; Huang, CQ; Peng, XD; Yang, B, 2009) |
| "Liver fibrosis was induced in male Sprague-Dawley (SD) rats by the injection of 40% CCl(4) subcutaneously twice a week for eight weeks." | 1.35 | Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats. ( Bai, Y; Dong, L; Shi, H; Zhang, L; Zhang, Y; Zhao, J, 2009) |
| "Deficiency of tPA aggravated liver fibrosis through promoting hepatic stellate cells (HSCs) activation and inhibiting ECM degradation by decreasing MMP-2, MMP-9 activities and disrupting the balance between MMP-13 and TIMP-1." | 1.35 | Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis. ( Hsiao, Y; Hu, H; Ling, CC; Song, HY; Tao, XM; Zou, T, 2008) |
| "Hepatocyte growth factor (HGF) inhibits liver fibrosis induced by carbon tetrachloride (CCl4) in animal models." | 1.35 | Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. ( Hagiwara, S; Ichikawa, T; Kakizaki, S; Kosone, T; Mori, M; Otsuka, T; Sato, K; Sohara, N; Takagi, H; Yamazaki, Y, 2008) |
| "Baoganning can effectively ameliorate liver fibrosis in rats possibly through reducing serum leptin level and inhibiting hepatic leptin and its receptor expressions." | 1.35 | [Effect of Baoganning on serum and hepatic leptin and its receptor levels in rats with liver fibrosis]. ( He, SQ; Hou, LY; Wen, B, 2008) |
| "Adenosine is a potent endogenous regulator of tissue repair that is released from injured cells and tissues." | 1.35 | Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. ( Chan, ES; Chiriboga, L; Cronstein, BN; Fernandez, P; Peng, Z; Wilder, T; Yee, H, 2008) |
| "Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups." | 1.35 | Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis. ( Comert, B; Mas, MR; Mas, N; Ocal, R; Tasci, I, 2008) |
| " In addition, in CH livers, PP dose-response curves to the NO donor, S-nitroso-N-acetyl-D,L-penicillamine (SNAP), were performed after pre-incubation with Ibtx or its vehicle." | 1.35 | Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis. ( Abraldes, JG; Bataller, R; Bosch, J; García-Pagán, JC; Graupera, M; Matei, V; Rodríguez-Vilarrupla, A, 2008) |
| " In dose-response experiments, the minimum dose of PYRRO/NO required to acutely lower PVP by 20%, the amount believed to yield a clinically meaningful outcome, was 200 nmol/kg." | 1.35 | Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice. ( Edwards, C; Feng, HQ; Mao, L; Reynolds, C; Rockey, DC, 2008) |
| " Experimental hepatic fibrosis was induced by subcutaneous injection of carbon tetrachloride (CCl4 soluted in liquid paraffin with the concentration of 300 g/L, the dosage of injection was 3 mL/kg, twice per week for 8 wk)." | 1.35 | Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis. ( Jiang, MD; Qin, JP; Wu, XL; Xu, H; Zeng, WZ, 2008) |
| "Carbon tetrachloride (CCl4) is a xenobiotic used extensively to induce oxidative stress and is one of the most widely used hepatic toxins for experimental induction of liver fibrosis in the laboratory." | 1.35 | Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. ( Ho, PC; Hsieh, YS; Huang, CY; Liu, JY; Liu, YC; Shyu, JC; Tsai, CC; Tsai, JH; Wu, TT, 2008) |
| " For the treated group, rats were administered with DBD at a dosage of 6 g/kg body weight once a day by gastrogavage starting from the day of modeling for 6 successive weeks and to the control group, equal volume of normal saline was administered instead." | 1.35 | [Effects of Danggui Buxue Decoction on liver fibrosis and hepatic lipid peroxidation in rats]. ( Chen, Y; Li, FH; Tao, YY, 2008) |
| "CCl4-induced liver fibrosis in rats was not aggravated by corn oil treatment." | 1.35 | Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats. ( Fang, HL; Lin, WC, 2008) |
| "We treated carbon tetrachloride (CCl(4)) into rats for eight weeks to induce liver fibrosis and arranged these rats for cholinergic denervation, hepatic branch vagotomy or atropine administration." | 1.35 | Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. ( Cheng, JT; Cheng, KC; Hsu, CT; Lam, HB; Yeh, CH, 2008) |
| "Liver fibrosis is usually progressive, but it can occasionally be reversible if the causative agents are adequately removed or if patients are treated effectively." | 1.34 | Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. ( Higashiyama, R; Hong, YY; Inagaki, Y; Kushida, M; Matsuzaki, Y; Nakao, S; Niioka, M; Okano, H; Okazaki, I; Shiota, G; Watanabe, T, 2007) |
| "Advanced liver cirrhosis is associated with hyperdynamic circulation consisting of systemic hypotension, decreased peripheral resistance, and cardiac dysfunction, termed cirrhotic cardiomyopathy." | 1.34 | Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. ( Bátkai, S; Harvey-White, J; Kechrid, R; Kunos, G; Mukhopadhyay, P; Pacher, P, 2007) |
| "Non-invasive staging of human liver fibrosis is a desirable objective that remains under extensive evaluation." | 1.34 | Rating of CCl(4)-induced rat liver fibrosis by blood serum glycomics. ( Chen, C; Contreras, R; De Hemptinne, B; Desmyter, L; Fan, YD; Jaworski, T; Praet, M; Vervecken, W, 2007) |
| "The extent and kinetic of the disease progression were followed by the measurement of ultrasound backscatter intensity." | 1.34 | Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice. ( Champy, MF; D'Sa, A; Garo, E; Guimond, A; Monassier, L; Selloum, M; Teletin, M; Vonesch, JL, 2007) |
| "Cystamine can ameliorate CCl(4) induced liver fibrosis and protect hepatic function." | 1.34 | Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase. ( Chen, W; Qiu, JF; Wu, ZY; Zhang, ZQ, 2007) |
| " Moreover, hepatic endothelial function was evaluated in isolated and perfused rat livers by dose-response curves to acetylcholine." | 1.34 | Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis. ( Bosch, J; Brandes, RP; Fernández, M; García-Pagán, JC; Gracia-Sancho, J; Laviña, B; Rodríguez-Vilarrupla, A, 2007) |
| "The model for inducing liver cirrhosis in rats was established according to a previously published protocol." | 1.34 | Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. ( Guo, H; Hao, ZM; Li, YC; Xue, H, 2007) |
| "Carbon tetrachloride---induced liver fibrosis revealed scar-associated macrophages that persisted throughout recovery." | 1.33 | Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. ( Clay, S; Constandinou, CM; Duffield, JS; Forbes, SJ; Iredale, JP; Lang, R; Partolina, M; Vuthoori, S; Wu, S, 2005) |
| "The CCl4-induced liver fibrosis markedly caused liver atrophy and splenomegalia, while AFE increased the liver weight, and decreased the spleen weight." | 1.33 | Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats. ( Lin, WC; Shih, CC; Wu, YW, 2005) |
| " However, the increase in CCl(4) dosage significantly worsened survival." | 1.33 | Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. ( Chang, ML; Chang, PY; Chen, JC; Yeh, CT, 2005) |
| " With repetitive dosing CCl(4) can be used to induce bridging hepatic fibrosis (4 wk of twice-weekly dosing), cirrhosis (8 wk of twice-weekly dosing) and advanced micronodular cirrhosis (12 wk of twice-weekly dosing)." | 1.33 | Modeling liver fibrosis in rodents. ( Constandinou, C; Henderson, N; Iredale, JP, 2005) |
| "Carbon tetrachloride intoxication was performed on rats for 2, 8, 12 or 20 weeks and 5x10(4) IU vitamin A (as retinol palmitate) was injected subcutaneously once every 4 weeks." | 1.33 | The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. ( Cavusoglu, I; Minbay, FZ; Noyan, S, 2006) |
| "The extent of liver fibrosis was assessed by measuring the level of liver hydroxy proline (HP) and serum enzyme levels." | 1.33 | Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.? ( Chidambaranathan, N; Christina, AJ; Kothai, R; Nalini, G; Robert, SJ; Saraswathy, GR; Therasal, RL, 2006) |
| "Liver fibrosis was induced in mice by administering carbon tetrachloride (CCl4) continuously for 10 weeks." | 1.33 | Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice. ( Chou, WY; Concejero, AM; Jawan, B; Kuo, HM; Lee, TH; Lu, CN; Wang, CH; Wu, CL, 2006) |
| "A model of liver cirrhosis was replicated in rats by intra-peritoneal injection of CCl4 for 8 wk." | 1.33 | Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. ( Feng, YY; Han, J; Lu, YY; Ma, XM; Su, SH; Wang, CP; Xiang, Y; Yang, YP, 2006) |
| "CCl(4) caused liver fibrosis, featuring increased prothrombin time, hepatic MDA and HP contents, and spleen weight and decreased plasma albumin level." | 1.33 | Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats. ( Fang, HL; Kuo, SC; Lin, WC; Lin, WL; Wang, BC, 2006) |
| "Liver cirrhosis was induced by intraperitoneal administration of CCl4 at a dose of 0." | 1.33 | Cryopreserved fetal liver cell transplants support the chronic failing liver in rats with CCl4-induced cirrhosis. ( Fuller, BJ; Mazur, SP; Ochenashko, OV; Petrenko, AY; Somov, AY; Volkova, NA, 2006) |
| "Immune-induced and CCL4-induced liver fibrosis models were established by dexamethasone (0." | 1.33 | Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models. ( Li, J; Luo, XD; Nie, QH; Shao, B; Xie, YM; Zhang, YF; Zhou, YX, 2006) |
| "Liver fibrosis is characterized by accumulation of extracellular matrix proteins synthesized by activated hepatic stellate cells (HSCs)." | 1.33 | Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. ( Jiang, F; Parsons, CJ; Stefanovic, B, 2006) |
| "1." | 1.33 | Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. ( Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H, 2006) |
| "Liver function, liver fibrosis, oxidative stress and expression of transforming growth factor beta1 (TGF-beta1), a-smooth muscle actin (alpha-SMA) and type I collagens in liver were determined." | 1.33 | Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. ( Fu, H; He, SX; Liu, EQ; Luo, JY; Wang, YL; Wang, YP; Xu, JL; Zhao, G, 2006) |
| "The only novel protein with regard to liver fibrosis depicting a unidirectional expression pattern in both animal models was Sbp2." | 1.33 | Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis. ( Berres, ML; Graf, J; Henkel, C; Hillebrandt, S; Lammert, F; Meyer, HE; Roderfeld, M; Roeb, E; Stühler, K; Weiskirchen, R, 2006) |
| "Rat liver fibrosis was induced by subcutaneous injection of tetrachloride (CCl4)." | 1.33 | Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats. ( Chen, H; Cong, X; Fei, R; Gao, Y; Liu, F; Wang, Y; Wei, L; Zhan, Y, 2006) |
| "Hepatic encephalopathy is a neurologic syndrome secondary to liver failure that causes cognitive and motor abnormalities." | 1.33 | Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis. ( Bartolí, R; Chatauret, N; Córdoba, J; Odena, G; Oria, M; Planas, R; Raguer, N, 2006) |
| " A portal perfusion pressure dose-response curve to methoxamine was performed in control and cirrhotic rat livers preincubated with vehicle, the nitric oxide synthase blocker N(G)-nitro-L-arginine (L-NNA), indomethacin cyclooxygenase (COX) inhibitor, L-NNA + indomethacin, or the thromboxane (TX) A(2) receptor blocker SQ 29,548." | 1.32 | Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. ( Abraldes, JG; Bosch, J; Bragulat, M; Corominola, H; García-Pagán, JC; Graupera, M; Peralta, C; Rodés, J, 2003) |
| "Liver fibrosis is characterized by a dramatic increase in the expression of type I collagen." | 1.32 | DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. ( Breindl, M; Brenner, DA; Gillan, A; Reif, S; Rippe, RA; Scanga, A; Yang, L; Yata, Y, 2003) |
| "The liver fibrosis was induced by CCl(4) subcutaneous injection." | 1.32 | Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. ( Chen, XB; Jiang, MD; Lei, CT; Wang, PL; Wang, Z; Wu, XL; Xu, H; Zeng, WZ; Zhang, Y, 2003) |
| "A key feature of recovery from liver fibrosis is hepatic stellate cell (HSC) apoptosis, which serves the dual function of removing the major source of neomatrix and tissue inhibitors of metalloproteinases thereby facilitating matrix degradation." | 1.32 | Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis. ( Benyon, RC; Constandinou, CM; Frantz, G; Gray, AM; Hillan, K; Iredale, JP; Kendall, T; Mann, DA; Oakley, F; Trim, N; Ye, W, 2003) |
| "Liver cirrhosis was inflicted in rats by percutaneous injection of 40% CCl4 on the back." | 1.32 | Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis. ( Liu, QG; Ma, QY; Pan, CE; Yang, W; Yao, YM; Zhang, M, 2003) |
| "Throughout different stages of liver fibrosis, leptin immunoreactivity was localized in activated hepatic stellate cells only, whereas immunoreactivity for the receptor was mainly seen on hepatocytes." | 1.32 | Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. ( Bornstein, SR; Fölsch, UR; Kloehn, S; Mönig, H; Otte, C; Otte, JM; Strodthoff, D, 2004) |
| "Following confirmation of CCl(4)-induced liver fibrosis, GbE or saline was administrated to the rats for 4 weeks." | 1.32 | Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats. ( Luo, YJ; Shi, ZH; Wang, L; Yu, JP, 2004) |
| "However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations." | 1.32 | Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice. ( Jiang, Y; Kang, YJ; Liu, J; Waalkes, M, 2004) |
| "Hepatic cirrhosis was induced in male Sprague-Dawley rats by intraperitoneal injection of carbon tetrachloride, and the cirrhotic rats were divided into three groups:Liposome-pcDNA(3)/iNOS (n = 10), Tris buffer (n = 10) and nude plasmid (n = 10), which were injected into the portal vein of experiment cirrhotic rats respectively." | 1.32 | [Experimental study on iNOS gene transfer mediated by liposome to treat portal hypertension in cirrhotic rats]. ( Luo, HF; Qiu, JF; Wu, ZY; Zhang, ZQ, 2004) |
| "The inhibitory rate of normal rat HSC proliferation caused by 100 mL/mL sera containing medium and high dosages of BOL showed a remarkable difference as compared with that caused by colchicine (medium dosage group: 34." | 1.32 | Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells. ( Weng, H; Yao, L; Yao, ZM; Yu, T; Zhao, GP; Zhou, YJ, 2004) |
| "Liver cirrhosis was produced by an 8-week intraperitoneal injection of CCl(4) in male Sprague-Dawley rats." | 1.32 | Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats. ( Goto, T; Kataoka, E; Lin, JG; Mikami, K; Miura, K; Odashima, M; Ohshima, S; Otaka, M; Segawa, D; Watanabe, D; Watanabe, S; Yoneyama, K, 2004) |
| "CCl4-induced liver fibrosis enhanced lipid peroxidation and TIMPs activation, increased ALT and AST, depleted antioxidants SOD and GPx, and caused collagen deposition in liver tissue." | 1.32 | The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. ( Avenoso, A; Calatroni, A; Campo, GM; Campo, S; D'Ascola, A; Ferlazzo, AM, 2004) |
| "The pathogenesis of hypogonadism in liver cirrhosis is not well understood." | 1.32 | Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1. ( Casares, AD; Castilla, A; Castilla-Cortazar, I; Diaz-Sanchez, M; Diez, N; Diez-Caballero, F; Garcia-Fernandez, M; Gonzalez-Baron, S; Prieto, J; Puche, JE; Quiroga, J; Varela-Nieto, I, 2004) |
| "Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue." | 1.32 | Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. ( Bradford, BU; Brenner, DA; Brocks, B; Cheung, E; Cho, MS; Feirt, N; Hirth-Dietrich, C; Knorr, A; Kraft, S; Krebs, B; Lum, P; Mei, B; Ng, P; Pan, CQ; Parsons, CJ; Ramamoorthi, R; Roldan, G; Schauer, M; Tomkinson, A; Zahn, S, 2004) |
| " We found that changes in the relative position of specific genes to the NM occur during the chronic administration of CCl4, but also that such changes correlate with the proliferating status of the hepatocytes that goes from quiescence to regeneration to replicative senescence along the course of CCl4-induced liver fibrosis, indicating that specific configurations in the higher-order DNA structure underlie the stages of progression towards liver fibrosis." | 1.32 | Gene positional changes relative to the nuclear substructure during carbon tetrachloride-induced hepatic fibrosis in rats. ( Aranda-Anzaldo, A; Gariglio, P; Hernández-Muñoz, R; Maya-Mendoza, A, 2004) |
| "Liver cirrhosis is caused by a relative imbalance between synthesis and degradation of collagens." | 1.32 | Arg-Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen production and acceleration of collagenase activity. ( Enjoji, M; Fukushima, M; Kobayashi, N; Kohjima, M; Kotoh, K; Morizono, S; Nakamuta, M; Nawata, H, 2004) |
| "And tamoxifen was given to male fibrosis model." | 1.31 | Estrogen reduces CCL4- induced liver fibrosis in rats. ( Chang, XM; Dong, L; Gong, J; Hao, ZM; Jia, A; Luo, JY; Xu, GP; Xu, JW, 2002) |
| " Higher dosage of losartan had deleterious effects in BDL rats." | 1.31 | Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. ( Calès, P; Chappard, D; Croquet, V; Douay, O; Gallois, Y; Moal, F; Oberti, F; Roux, J; Veal, N; Vuillemin, E; Wang, J, 2002) |
| " The aim of this study was to evaluate the effect of Pirfenidone in the reversion or prevention of cirrhosis experimentally induced in rats by chronic administration of CCl(4) and bile-duct ligation (BDL)." | 1.31 | Pirfenidone effectively reverses experimental liver fibrosis. ( Armendariz-Borunda, J; Garcia, J; García, L; Grijalva, G; Hernández, I; Margolin, S; Muriel, P; Salazar, A; Sandoval, A; Vera, J, 2002) |
| "Liver cirrhosis was induced by an intraperitoneal injection of 50% CCl(4) (0." | 1.31 | [Effects of ET-1 on isolated perfused rat liver and vascular rings at two stages of cirrhosis]. ( Fang, H; Feng, Z; Gao, J; Yang, C; Yao, D; Yao, X, 2002) |
| "Thioacetamide and CCl4 were administered to rats for 8 and 30 weeks, respectively before rats were killed and autopsies performed at 9, 20 and 30 weeks later." | 1.31 | Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide. ( Bae, IH; Jang, JJ; Jeong, DH; Jeong, KS; Kim, MR; Lee, JH; Lee, MJ; Lee, SJ; Lee, YS; Lim, IK, 2001) |
| "Our data suggest that liver cirrhosis induced by CCl4 or TAA is associated with alterations in cell cycle-related proteins, and that the expression of these proteins is responsible for hepatocyte regeneration in the damaged liver and may be involved in liver carcinogenesis." | 1.31 | Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide. ( Jang, JJ; Jeong, DH; Lee, JH; Lee, MJ; Lee, SJ; Lee, YS; Lim, IK, 2001) |
| "Liver cirrhosis was induced by CCl(4) inhalation and phenobarbital in Wistar rats." | 1.31 | Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats. ( Castilla-Cortázar, I; García, M; Muguerza, B; Prieto, J; Quiroga, J; Santidrián, S, 2001) |
| "Gliotoxin treatment significantly reduced the number of activated stellate cells and mean thickness of bridging fibrotic septae in livers from rats treated with carbon tetrachloride." | 1.31 | Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. ( Arthur, MJ; Iredale, JP; Issa, R; Mann, DA; Murray, GI; Primrose, JN; Smart, DE; Trim, N; Wright, MC, 2001) |
| " This simple and sensitive assay method was feasibly applied to the pharmacokinetic study of propranolol after intravenous administration of 2 mg/kg of propranolol to normal and carbon tetrachloride-induced liver cirrhotic rats." | 1.31 | Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection. ( Hong, JH; Kang, JS; Kim, HK; Lee, MH; Park, MS, 2001) |
| "In different groups of portally perfused control and cirrhotic rat livers, the following were analyzed: a portal perfusion pressure (PP) dose-response curve to LTD4; the effects on PP caused by either vehicle, the selective 5-lipoxygenase inhibitor AA-861, the selective Cys-LT1 receptor antagonist MK-571, or the dual Cys-LT1 and Cys-LT2 receptor antagonist BAY u9773; and immunohistochemistry for 5-lipoxygenase in liver sections of cirrhotic and control livers." | 1.31 | 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. ( Bosch, J; Claria, J; García-Pagán, JC; Graupera, M; Massaguer, A; Rodés, J; Titos, E, 2002) |
| "2." | 1.31 | Neutrophil migration during liver cirrhosis in rabbits. ( Bernascconi, G; Calafatti, SC; Ferreira, HH; Pedrazzoli, J; Penteado, FC; Piovesana, H, 2002) |
| " This study investigated the effects of chronic administration of octreotide on systemic and portal haemodynamics and the development of portal hypertensive gastropathy in carbon tetrachloride-induced cirrhotic rats." | 1.30 | Chronic administration of octreotide ameliorates portal hypertension and portal hypertensive gastropathy in rats with cirrhosis. ( Chan, CC; Chang, FY; Chu, CJ; Lee, FY; Lee, SD; Lin, HC; Lin, HJ; Tai, CC; Wang, SS; Wu, SL, 1998) |
| "In experimental models of liver fibrosis, CTGF accumulated in parallel with the development of septal fibrosis and cirrhosis." | 1.30 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis. ( Ba, N; Bedossa, P; Dargere, D; De Gouville, AC; Gauthier, JM; Huet, S; Martinez, V; Paradis, V; Ratziu, V; Sobesky, R; Vidaud, M, 1999) |
| " The chronic administration of carbon tetrachloride was also found to produce liver fibrosis as seen from pathological analysis as well as elevated liver-hydroxy proline." | 1.29 | Inhibition of liver fibrosis by ellagic acid. ( Kuttan, R; Thresiamma, KC, 1996) |
| "There was severe liver fibrosis in toxifying control, but the degree of liver fibrosis in YQHX group was significantly milder than that in toxifying control." | 1.28 | [Experimental study on yiqi-huoxue therapy of liver fibrosis]. ( Fu, QL, 1992) |
| "The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 1.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
| "Colchicine treatment prevented the modifications in ATPases when given simultaneously with CCl4 and reverted the alterations in ATPase activities of the CCl4-cirrhotic animals." | 1.27 | Cryptic adenosine triphosphatase activities in plasma membranes of CCl4-cirrhotic rats. Its modulation by changes in cholesterol/phospholipid ratios. ( Amaya, A; Mourelle, M; Rojkind, M; Yahuaca, P, 1985) |
| "The frequency of hepatomata was almost equal in the aflatoxin and aflatoxin-carbon tetrachloride group." | 1.25 | Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. ( Lageron, A; Lemonnier, FJ; Scotto, JM; Stralin, HG, 1975) |
| "Collagen synthesis was found to be increased in liver slices of rats made cirrhotic by chronic administration of CCl4." | 1.25 | Effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices. ( Kershenobich, D; Rojkind, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 120 (8.65) | 18.7374 |
| 1990's | 14 (1.01) | 18.2507 |
| 2000's | 265 (19.09) | 29.6817 |
| 2010's | 699 (50.36) | 24.3611 |
| 2020's | 290 (20.89) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 25 |
| Martin-Mateos, R | 2 |
| Li, J | 57 |
| Yin, Z | 1 |
| Lu, X | 4 |
| Glaser, KJ | 2 |
| Mounajjed, T | 2 |
| Yashiro, H | 1 |
| Siegelman, J | 1 |
| Winkelmann, CT | 1 |
| Wang, J | 30 |
| Ehman, RL | 2 |
| Shah, VH | 6 |
| Yin, M | 5 |
| Zhao, W | 2 |
| Zhang, X | 40 |
| Hou, M | 1 |
| Zhang, Y | 54 |
| Tang, Y | 3 |
| Li, L | 21 |
| Dong, S | 3 |
| Liu, L | 11 |
| Zhao, D | 1 |
| Li, W | 17 |
| Nan, Y | 1 |
| Sun, BR | 1 |
| Li, HY | 2 |
| Wang, GP | 1 |
| Jia, QA | 1 |
| Zhang, C | 21 |
| Yang, A | 3 |
| Yan, X | 3 |
| Xu, H | 12 |
| Fan, X | 8 |
| Zhang, M | 16 |
| Huang, T | 2 |
| Chen, W | 14 |
| Jia, J | 2 |
| You, H | 5 |
| Wang, Y | 53 |
| Xiao, X | 3 |
| Wang, X | 29 |
| Guo, F | 4 |
| Zhu, H | 4 |
| Zhao, H | 5 |
| Xu, S | 3 |
| Ding, Y | 5 |
| Huang, C | 22 |
| Ma, T | 3 |
| Hao, LS | 1 |
| Song, J | 2 |
| Wu, RP | 1 |
| Zhang, PL | 1 |
| Ji, JX | 1 |
| Jiang, MY | 1 |
| Mo, YB | 1 |
| Abdelhamid, AM | 1 |
| Youssef, ME | 1 |
| Abd El-Fattah, EE | 1 |
| Gobba, NA | 1 |
| Gaafar, AGA | 1 |
| Girgis, S | 1 |
| Shata, A | 1 |
| Hafez, AM | 1 |
| El-Ahwany, E | 2 |
| Amin, NA | 1 |
| Shahien, MA | 1 |
| Abd-Eldayem, MA | 1 |
| Abou-Elrous, M | 1 |
| Saber, S | 2 |
| Le, TV | 1 |
| Dinh, NBT | 1 |
| Dang, MT | 1 |
| Phan, NCL | 1 |
| Dang, LTT | 1 |
| Grassi, G | 1 |
| Holterman, AXL | 1 |
| Le, HM | 1 |
| Truong, NH | 1 |
| Chen, Y | 42 |
| Que, R | 3 |
| Zhang, N | 6 |
| Lin, L | 4 |
| Zhou, M | 4 |
| Li, Y | 41 |
| Li, X | 33 |
| Li, H | 22 |
| Zhang, S | 22 |
| Zhang, R | 8 |
| Wei, Y | 5 |
| Yang, C | 8 |
| Zhang, F | 24 |
| Zhou, H | 8 |
| Xu, L | 8 |
| Ma, J | 9 |
| Wang, Q | 9 |
| Xiong, X | 1 |
| Chu, S | 1 |
| Bi, H | 2 |
| Cui, L | 3 |
| He, W | 3 |
| Tian, Y | 2 |
| Liu, F | 7 |
| Gao, G | 1 |
| Wang, Z | 23 |
| Chen, N | 2 |
| Wang, H | 30 |
| Xiao, Z | 2 |
| Ji, Q | 1 |
| Fu, YD | 1 |
| Gao, SQ | 1 |
| Hu, YH | 1 |
| Liu, W | 8 |
| Chen, GF | 1 |
| Mu, YP | 3 |
| Chen, JM | 4 |
| Liu, P | 13 |
| Ge, S | 4 |
| Yang, W | 5 |
| Chen, H | 5 |
| Yuan, Q | 2 |
| Liu, S | 4 |
| Zhao, Y | 25 |
| Zhang, J | 29 |
| Zhang, L | 23 |
| Wang, W | 10 |
| Wei, F | 1 |
| Zhang, YW | 1 |
| Tu, LL | 1 |
| Pan, JC | 1 |
| Zheng, GL | 1 |
| Yin, LN | 1 |
| Hung, CT | 1 |
| Su, TH | 2 |
| Chen, YT | 4 |
| Wu, YF | 1 |
| Lin, SJ | 1 |
| Lin, SL | 1 |
| Yang, KC | 1 |
| Kostallari, E | 1 |
| Wei, B | 2 |
| Sicard, D | 2 |
| Cooper, SA | 1 |
| Gao, J | 6 |
| Dehankar, M | 1 |
| Cao, S | 6 |
| Tschumperlin, DJ | 1 |
| Zheng, WV | 1 |
| Cheng, X | 4 |
| Xu, Y | 13 |
| Zhou, T | 2 |
| Li, D | 7 |
| Xiong, Y | 4 |
| Wang, S | 17 |
| Chen, Z | 7 |
| Yuan, Z | 1 |
| He, J | 5 |
| Xie, T | 1 |
| Chen, TT | 1 |
| Shi, LP | 1 |
| He, Y | 6 |
| Shao, M | 2 |
| Che, JY | 1 |
| Omar, ZMM | 1 |
| Ahmed, AA | 1 |
| El-Bakry, MH | 1 |
| Ahmed, MA | 1 |
| Hasan, A | 1 |
| Gong, X | 2 |
| Shan, L | 2 |
| Li, K | 4 |
| Wu, Y | 13 |
| Zhang, Q | 14 |
| Wen, S | 1 |
| Fang, B | 3 |
| Li, C | 14 |
| Huang, Q | 7 |
| Lin, X | 6 |
| Tong, G | 2 |
| Chen, X | 24 |
| Lee, J | 3 |
| Fan, J | 7 |
| Li, S | 21 |
| Zhu, K | 2 |
| Hu, Z | 5 |
| Mei, L | 1 |
| Sui, Y | 1 |
| Dong, Y | 6 |
| Chen, R | 3 |
| Jin, Z | 1 |
| Zhou, B | 2 |
| Cong, W | 2 |
| Huang, P | 5 |
| Jin, L | 4 |
| Abdelghffar, EA | 1 |
| Obaid, WA | 1 |
| Alamoudi, MO | 1 |
| Mohammedsaleh, ZM | 1 |
| Annaz, H | 1 |
| Abdelfattah, MAO | 1 |
| Sobeh, M | 1 |
| Chen, D | 3 |
| Xiong, J | 1 |
| Feng, H | 5 |
| Liu, Y | 35 |
| Xu, J | 11 |
| Rafiq, H | 1 |
| Ayaz, M | 1 |
| Khan, HA | 1 |
| Iqbal, M | 1 |
| Quraish, S | 1 |
| Afridi, SG | 1 |
| Khan, A | 4 |
| Khan, B | 1 |
| Sher, A | 1 |
| Siraj, F | 1 |
| Shams, S | 3 |
| Guo, HB | 1 |
| Shao, CP | 1 |
| Wang, L | 29 |
| Xu, YQ | 1 |
| Zhou, YM | 1 |
| Fan, K | 2 |
| Zan, X | 1 |
| Zhi, Y | 1 |
| Yang, Y | 26 |
| Hu, K | 2 |
| Zhao, S | 9 |
| Chen, K | 5 |
| Tian, R | 1 |
| Jiang, YC | 1 |
| Han, X | 3 |
| Dou, JY | 1 |
| Yuan, MH | 1 |
| Zhou, MJ | 1 |
| Cui, ZY | 1 |
| Lian, LH | 2 |
| Nan, JX | 3 |
| Wu, YL | 3 |
| Song, Z | 2 |
| Liu, X | 28 |
| Zhang, W | 15 |
| Luo, Y | 4 |
| Xiao, H | 1 |
| Dai, G | 2 |
| Hong, J | 2 |
| Li, A | 3 |
| Zhang, RZ | 1 |
| Li, M | 11 |
| Huang, YL | 1 |
| Song, ZH | 1 |
| Dong, HJ | 1 |
| Guo, Y | 12 |
| Liu, T | 6 |
| Zhao, J | 5 |
| Di Paola, R | 1 |
| Modafferi, S | 1 |
| Siracusa, R | 1 |
| Cordaro, M | 1 |
| D'Amico, R | 1 |
| Ontario, ML | 1 |
| Interdonato, L | 1 |
| Salinaro, AT | 1 |
| Fusco, R | 1 |
| Impellizzeri, D | 1 |
| Calabrese, V | 1 |
| Cuzzocrea, S | 1 |
| Qiu, JL | 2 |
| Chai, YN | 1 |
| Duan, FY | 1 |
| Zhang, HJ | 1 |
| Han, XY | 1 |
| Chen, LY | 2 |
| Duan, F | 1 |
| Faccioli, LAP | 1 |
| Dias, ML | 1 |
| Paranhos, BA | 1 |
| Dos Santos Goldenberg, RC | 1 |
| Zein, N | 1 |
| Yassin, F | 1 |
| Makled, S | 1 |
| Alotaibi, SS | 1 |
| Albogami, SM | 1 |
| Mostafa-Hedeab, G | 1 |
| Batiha, GE | 1 |
| Elewa, YHA | 1 |
| Kim, SM | 2 |
| Song, GY | 1 |
| Shim, A | 1 |
| Lee, JH | 9 |
| Eom, CB | 1 |
| Liu, C | 19 |
| Yang, YM | 1 |
| Seki, E | 5 |
| Bai, L | 2 |
| Wang, YL | 4 |
| Chen, YL | 1 |
| Li, HX | 1 |
| Zhu, SW | 1 |
| Song, ZC | 1 |
| Duan, SZ | 1 |
| Wang, C | 9 |
| Ma, C | 4 |
| Fu, K | 1 |
| Gong, L | 2 |
| Peng, C | 2 |
| Cao, M | 1 |
| Dai, Y | 2 |
| Zhou, Y | 17 |
| Xian, L | 1 |
| Zheng, R | 1 |
| Wan, X | 1 |
| Zou, LQ | 2 |
| Liu, HF | 3 |
| Du, YN | 2 |
| Xing, W | 3 |
| Chen, XF | 1 |
| Ji, S | 4 |
| Huang, S | 4 |
| Qian, X | 1 |
| Jiang, T | 1 |
| Xiao, J | 3 |
| Xiong, M | 1 |
| Wen, Z | 3 |
| Di, Z | 1 |
| Muyun, W | 1 |
| Luan, C | 1 |
| Hao, WU | 1 |
| Ting, W | 1 |
| Zhiruo, Z | 1 |
| Ying, Z | 1 |
| Juan, YU | 1 |
| Jinming, H | 1 |
| Jinhang, Z | 1 |
| Shengying, Q | 1 |
| Hamang, M | 1 |
| Culver, A | 1 |
| Jiang, H | 11 |
| Yanum, J | 1 |
| Garcia, V | 1 |
| White, E | 1 |
| Kusumanchi, P | 1 |
| Chalasani, N | 1 |
| Liangpunsakul, S | 2 |
| Yaden, BC | 1 |
| Kim, KH | 6 |
| Cheng, N | 2 |
| Lau, LF | 2 |
| Sun, Z | 5 |
| Zhan, X | 1 |
| Wang, T | 8 |
| Zhu, J | 12 |
| Gao, L | 10 |
| Wei, M | 1 |
| Zhang, D | 2 |
| Chen, L | 19 |
| Wu, H | 6 |
| Xing, Q | 1 |
| He, L | 2 |
| Hong, F | 2 |
| Qin, S | 2 |
| Guo, YW | 1 |
| Pang, PJ | 1 |
| Sun, YK | 1 |
| Ge, X | 5 |
| Wang, SN | 1 |
| Zhang, CQ | 2 |
| Yu, Y | 8 |
| Zhu, S | 4 |
| Gong, W | 1 |
| Baogui, XU | 1 |
| Jiawen, Z | 1 |
| Xiaoxiao, T | 1 |
| Falei, Y | 1 |
| Zhongliang, L | 1 |
| Zuisu, Y | 1 |
| Xianjun, D | 1 |
| Shao, J | 16 |
| Ge, T | 1 |
| Tang, C | 1 |
| Wang, G | 9 |
| Pang, L | 1 |
| Wang, P | 5 |
| Fang, Y | 3 |
| Qiu, J | 3 |
| Jiang, C | 3 |
| Panera, N | 1 |
| Braghini, MR | 1 |
| Crudele, A | 1 |
| Smeriglio, A | 1 |
| Bianchi, M | 1 |
| Condorelli, AG | 1 |
| Nobili, R | 1 |
| Conti, LA | 1 |
| De Stefanis, C | 1 |
| Lioci, G | 1 |
| Gurrado, F | 1 |
| Comparcola, D | 1 |
| Mosca, A | 1 |
| Sartorelli, MR | 1 |
| Scoppola, V | 1 |
| Svegliati-Baroni, G | 3 |
| Trombetta, D | 1 |
| Alisi, A | 1 |
| Zetterberg, FR | 1 |
| MacKinnon, A | 1 |
| Brimert, T | 1 |
| Gravelle, L | 1 |
| Johnsson, RE | 1 |
| Kahl-Knutson, B | 1 |
| Leffler, H | 1 |
| Nilsson, UJ | 1 |
| Pedersen, A | 1 |
| Peterson, K | 1 |
| Roper, JA | 1 |
| Schambye, H | 1 |
| Slack, RJ | 1 |
| Tantawi, S | 1 |
| Sun, TT | 1 |
| Liu, XL | 2 |
| Yang, GY | 1 |
| Tao, L | 3 |
| Ma, WT | 1 |
| Wu, L | 10 |
| Li, Q | 11 |
| Chen, T | 7 |
| Shi, Z | 3 |
| Meng, X | 5 |
| Zheng, L | 7 |
| Yao, Q | 3 |
| Lin, H | 4 |
| Du, X | 2 |
| Zhang, K | 6 |
| Han, T | 2 |
| Hong, W | 2 |
| Ise, H | 1 |
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| Xiu, G | 1 |
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| Ma, Y | 3 |
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| Ren, H | 3 |
| Su, Q | 1 |
| Gong, P | 1 |
| Jin, Y | 3 |
| Zhang, H | 24 |
| Gu, J | 6 |
| Xu, W | 7 |
| Yuan, N | 1 |
| Sun, J | 4 |
| Xue, T | 3 |
| Yue, L | 4 |
| Zhu, G | 4 |
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| Liu, H | 16 |
| Gan, C | 3 |
| Fan, C | 4 |
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| Xie, Y | 4 |
| Ye, T | 5 |
| Li, YR | 2 |
| Zhao, YF | 2 |
| Cheng, GL | 2 |
| Wang, EL | 2 |
| Tan, YJ | 2 |
| Yao, JC | 2 |
| Zhang, GM | 2 |
| Guo, Q | 7 |
| Huang, ZL | 2 |
| Lu, B | 5 |
| Ji, LL | 2 |
| Rampa, DR | 2 |
| Allur-Subramaniyan, S | 2 |
| Shim, K | 2 |
| Pekcec, A | 2 |
| Lee, D | 2 |
| Doods, H | 2 |
| Wu, D | 6 |
| Yang, AT | 2 |
| Kim, YO | 4 |
| Yan, XZ | 2 |
| Abe, H | 2 |
| Aslam, M | 2 |
| Park, KS | 2 |
| Zhao, XY | 4 |
| Jia, JD | 2 |
| Klein, T | 2 |
| Schuppan, D | 8 |
| Xing, B | 2 |
| Lan, H | 2 |
| Huang, Y | 15 |
| Wang, ZL | 2 |
| Ye, LM | 1 |
| Guo, WQ | 1 |
| Zhang, JJ | 2 |
| Ying, H | 1 |
| Ni, F | 1 |
| Iwanaga, T | 1 |
| Chiba, T | 1 |
| Nakamura, M | 1 |
| Kaneko, T | 1 |
| Ao, J | 1 |
| Qiang, N | 1 |
| Kogure, T | 2 |
| Yumita, S | 1 |
| Ishino, T | 1 |
| Ogawa, K | 1 |
| Kan, M | 1 |
| Nakagawa, M | 3 |
| Fujiwara, K | 1 |
| Fujita, N | 2 |
| Sakuma, T | 1 |
| Kanzaki, H | 1 |
| Koroki, K | 1 |
| Kusakabe, Y | 1 |
| Inoue, M | 1 |
| Kobayashi, K | 2 |
| Kanogawa, N | 1 |
| Kiyono, S | 1 |
| Kondo, T | 1 |
| Nakagawa, R | 1 |
| Ogasawara, S | 1 |
| Nakamoto, S | 1 |
| Muroyama, R | 1 |
| Kato, J | 1 |
| Kanda, T | 1 |
| Maruyama, H | 1 |
| Mimura, N | 1 |
| Honda, T | 1 |
| Murayama, T | 1 |
| Nakamura, H | 1 |
| Kato, N | 1 |
| Suk, FM | 1 |
| Hsu, FY | 2 |
| Lee, YC | 2 |
| Chen, TL | 1 |
| Chiu, WC | 1 |
| Liao, YJ | 3 |
| Alavifard, H | 1 |
| Mazhari, S | 2 |
| Meyfour, A | 1 |
| Tokhanbigli, S | 2 |
| Ghavami, S | 2 |
| Zali, MR | 2 |
| Aghdaei, HA | 2 |
| Hatami, B | 2 |
| Baghaei, K | 2 |
| Li, TT | 1 |
| Su, XW | 1 |
| Chen, LL | 2 |
| Zhang, WN | 1 |
| Zhang, JP | 3 |
| Xu, WH | 2 |
| Karpov, MA | 1 |
| Klochin, VD | 1 |
| Nadeev, AP | 1 |
| Shkurupy, VA | 1 |
| Marinkin, IO | 1 |
| Song, Y | 5 |
| Wei, J | 3 |
| Li, R | 14 |
| Fu, R | 2 |
| Han, P | 1 |
| Zhang, G | 6 |
| Chen, S | 7 |
| Liu, Z | 15 |
| Zhu, C | 2 |
| Pei, H | 1 |
| Cheng, J | 1 |
| Dong, L | 7 |
| Song, G | 2 |
| Shen, X | 6 |
| Zhao, T | 2 |
| Han, Z | 5 |
| Qiao, H | 3 |
| Gao, N | 1 |
| Xia, S | 1 |
| Wang, F | 15 |
| Yang, T | 3 |
| Xu, M | 3 |
| Kong, D | 7 |
| Zhang, Z | 26 |
| Xu, X | 8 |
| Zheng, S | 22 |
| Bedair, AF | 1 |
| Wahid, A | 2 |
| El-Mezayen, NS | 2 |
| Afify, EA | 1 |
| Oates, JR | 1 |
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| Giles, DA | 1 |
| Alarcon, PC | 1 |
| Damen, MSMA | 1 |
| Szabo, S | 1 |
| Stankiewicz, TE | 1 |
| Moreno-Fernandez, ME | 1 |
| Divanovic, S | 1 |
| Yin, L | 5 |
| Fan, S | 4 |
| Guo, PC | 1 |
| Zuo, J | 1 |
| Huang, KK | 1 |
| Lai, GY | 1 |
| An, J | 2 |
| Li, JX | 1 |
| Lin, YT | 2 |
| Wang, DY | 1 |
| Xu, JS | 1 |
| Hao, SJ | 1 |
| Li, RH | 1 |
| Ma, W | 3 |
| Song, YM | 1 |
| Liu, CY | 1 |
| Dai, Z | 2 |
| Sharma, AD | 2 |
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| Huo, F | 1 |
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| Li, YY | 1 |
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| Sun, X | 6 |
| Huang, K | 4 |
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| Guan, F | 1 |
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| Pająk, J | 1 |
| Wu, X | 5 |
| Zhu, Y | 9 |
| Zhao, Z | 6 |
| Li, Z | 18 |
| Rathod, DK | 1 |
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| Patil, RS | 1 |
| Wagdargi, SS | 1 |
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| Wu, T | 3 |
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| Zhao, R | 3 |
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| Liu, K | 2 |
| Yu, H | 8 |
| Qi, H | 3 |
| Ouyang, D | 1 |
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| Long, Z | 1 |
| Guo, T | 1 |
| Chen, C | 10 |
| Yun, T | 1 |
| Jing, T | 1 |
| Zang, X | 1 |
| Zhou, D | 5 |
| Xie, J | 6 |
| Yang, J | 10 |
| Ke, Z | 1 |
| Kan, N | 1 |
| Zheng, E | 1 |
| Qiu, Y | 5 |
| Huang, M | 2 |
| Zheng, F | 1 |
| Basit, A | 1 |
| Zhuang, H | 1 |
| da Silva, DJ | 1 |
| Ferreira, RR | 1 |
| da S Ferreira, G | 1 |
| Barbosa, RFS | 1 |
| Marciano, JS | 1 |
| Camani, PH | 1 |
| Souza, AG | 1 |
| Rosa, DS | 1 |
| Ge, Q | 1 |
| Norvell, MR | 1 |
| Porter, M | 1 |
| Ricco, MH | 1 |
| Koonce, RC | 1 |
| Hogan, CA | 1 |
| Basler, E | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Hepatitis C Management Protect Egyptian Population Against Severe Corona Virus Disease-2019 (COVID-19)?[NCT04757272] | 2,106 participants (Actual) | Observational | 2020-05-01 | Completed | |||
| A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients[NCT05637216] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-08-17 | Recruiting | ||
| Phase I Study of Mesenchymal Stromal Cells-Derived Exosomes With KrasG12D siRNA for Metastatic Pancreas Cancer Patients Harboring KrasG12D Mutation[NCT03608631] | Phase 1 | 15 participants (Actual) | Interventional | 2021-01-27 | Active, not recruiting | ||
| Clinical Study on the Value of Quantitative MRI Imaging in Diffuse Liver Diseases[NCT04626492] | 150 participants (Anticipated) | Observational [Patient Registry] | 2020-08-01 | Recruiting | |||
| Serelaxin To Lower Portal Pressure in Patients With Cirrhosis and Portal Hypertension[NCT02669875] | Phase 2 | 15 participants (Actual) | Interventional | 2017-10-18 | Completed | ||
| Quantitative Diagnosis of Liver Fibrosis on Multiparametric MRI[NCT03176797] | 300 participants (Anticipated) | Interventional | 2017-05-03 | Enrolling by invitation | |||
| Umbilical Cord Mesenchymal Stem Cell Transfusion in Patients With Severe Liver Cirrhosis[NCT01233102] | Phase 1/Phase 2 | 200 participants (Anticipated) | Interventional | 2009-10-31 | Suspended | ||
| The Health Effects of a Blueberry Enriched Diet on Obese Children: A Feasibility Study[NCT01809795] | 10 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Phase I Clinical Trial, Randomized, Controlled, to Evaluate the Efficacy and Safety of Therapy With Allogenic Mesenchymal Stem Cells From Bone Marrow for Patients With Refractory Primary Biliary Cirrhosis[NCT01440309] | Phase 1 | 20 participants (Anticipated) | Interventional | 2011-11-30 | Recruiting | ||
| The Effects of Leucine and Isoleucine on Glucose Metabolism[NCT02634164] | 12 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Mesenchymal Stem Cell Therapy for Liver Cirrhosis: A Phase I/II Study[NCT03626090] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2018-08-18 | Recruiting | ||
| Galectin-3 as a Predictor for Thromboembolic Formation in Patients With Non Valvular Atrial Fibrillation Assessed by CHA₂DS₂-VASc Scoring[NCT03413072] | 140 participants (Anticipated) | Observational | 2018-06-30 | Not yet recruiting | |||
| A Randomised, Controlled Trial of Losartan as an Anti-fibrotic Agent in Non-alcoholic Steatohepatitis[NCT01051219] | Phase 3 | 45 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for carbon tetrachloride and Liver Cirrhosis
| Article | Year |
|---|---|
Liver cirrhosis: An overview of experimental models in rodents.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Cirrhosis, Expe | 2022 |
Rodent Models of Nonalcoholic Fatty Liver Disease.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cholesterol, Dietary; Combined Modality Therapy; Diet, | 2020 |
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Pharmacological actions of curcumin in liver diseases or damage.
Topics: Animals; Carbon Tetrachloride; Cholestasis; Curcuma; Curcumin; Humans; Iron; Liver; Liver Cirrhosis; | 2009 |
Targeted treatments for cirrhosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Differentiati | 2004 |
Mouse models of liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Liver Ci | 2007 |
Autologous bone marrow cell infusion therapy for liver cirrhosis.
Topics: Albumins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differ | 2008 |
Prevention and treatment of liver fibrosis based on pathogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Cytochrome P-450 CYP2E1; Fat Emulsions, In | 1999 |
Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow.
Topics: Animals; Ascites; Bile Ducts; Blood Flow Velocity; Carbon Tetrachloride; Disease Models, Animal; Hem | 2001 |
Cirrhosis of the liver: a reversible disease?
Topics: Animals; Carbon Tetrachloride; Collagen; Diet; Ethionine; Female; Humans; Liver; Liver Cirrhosis; Li | 1979 |
Some immunological aspects of liver function.
Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Antigens, Bacterial; B-Lymphocytes; Carbon | 1975 |
[The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Topics: Animals; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Penici | 1990 |
Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals.
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemica | 1974 |
Intravascular coagulation in liver disease.
Topics: Animals; Blood Coagulation Factors; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Di | 1974 |
[Alcohol and liver disorders].
Topics: Adult; Alcoholic Beverages; Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liv | 1969 |
3 trials available for carbon tetrachloride and Liver Cirrhosis
| Article | Year |
|---|---|
The influence of mosapride on gut microbiota of carbon tetrachloride-induced cirrhosis rats based on 16S rRNA gene sequencing.
Topics: Animals; Bacteria; Benzamides; Carbon Tetrachloride; Gastrointestinal Microbiome; Genes, rRNA; Liver | 2022 |
Gender different response to immunonutrition in liver cirrhosis with sepsis in rats.
Topics: Animals; Carbon Tetrachloride; Diet; Female; Interleukin-10; Interleukin-1beta; Interleukin-6; Liver | 2012 |
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
Topics: Animals; Antineoplastic Agents; Biopsy; Carbon Tetrachloride; Dimethylnitrosamine; Disease Models, A | 2001 |
1370 other studies available for carbon tetrachloride and Liver Cirrhosis
| Article | Year |
|---|---|
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Elasticity Ima | 2021 |
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Topics: Adult; Animals; Antifibrotic Agents; Antiviral Agents; Carbon Tetrachloride; Case-Control Studies; C | 2021 |
C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
Topics: Adipokines; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix; Gene Knocko | 2021 |
Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis.
Topics: 3T3 Cells; Amino Acid Oxidoreductases; Animals; Base Sequence; Carbon Tetrachloride; Female; Fibrobl | 2021 |
Identification of differentially expressed long noncoding RNAs and pathways in liver tissues from rats with hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Regulatory Networks; Genetic Diseases, Inborn; High-Throughput N | 2021 |
Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and | 2021 |
[Dynamic expression of protein tyrosine phosphatase SHP2 in liver tissue of rats with carbon tetrachloride-induced liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-D | 2021 |
Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride.
Topics: Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Carbon Tetrachloride | 2021 |
Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroquine; Disea | 2022 |
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cells, Cultured; China; Fibrosis; Hepatic Stellate Cells; | 2021 |
Protective effect of Idelalisib on carbon tetrachloride-induced liver fibrosis via microRNA-124-3P/phosphatidylinositol-3-hydroxykinase signalling pathway.
Topics: Animals; Apoptosis; Biomarkers; Biopsy; Carbon Tetrachloride; Disease Models, Animal; Disease Suscep | 2021 |
NAMPT-mediated NAD
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatic Stellate Cells; Liver Cirrhos | 2021 |
Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl
Topics: Animals; Antifibrotic Agents; Carbon Tetrachloride; Cysteine; Disease Models, Animal; Gene Knockdown | 2021 |
Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling.
Topics: Amygdalin; Animals; Carbon Tetrachloride; Collagen Type I; Endothelial Cells; Hepatic Stellate Cells | 2023 |
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemokine CXCL2; Coculture Techniques; Disease Models, Ani | 2021 |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha protects a fibrotic liver from partial hepatectomy-induced advanced liver injury through regulating cell cycle arrest.
Topics: Animals; Carbon Tetrachloride; Cell Cycle Checkpoints; Cell Line; Hepatectomy; Humans; Liver Cirrhos | 2022 |
Long non‑coding RNA MBI‑52 inhibits the development of liver fibrosis by regulating the microRNA‑466g/SMAD4 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Liver Cir | 2022 |
Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Disease Mod | 2021 |
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver C | 2022 |
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Huma | 2022 |
Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Hepatocytes; Liver; Liver Cirrhosis; Uridine | 2022 |
Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis.
Topics: Actins; Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Antioxidants; Carbon Tetrachloride; | 2021 |
Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Ci | 2022 |
Notoginsenoside R1, An Active Compound from
Topics: Animals; Carbon Tetrachloride; Ginsenosides; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Panax n | 2022 |
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis.
Topics: Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herb | 2022 |
Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway.
Topics: Animals; Carbon Tetrachloride; Fibroblast Growth Factors; Hepatic Stellate Cells; Liver; Liver Cirrh | 2022 |
Thymus fontanesii attenuates CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Flavonoids; Inflammation; Lip | 2022 |
Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model.
Topics: Animals; Carbon Tetrachloride; Female; Liver Cirrhosis; Melatonin; Mesenchymal Stem Cell Transplanta | 2022 |
Shugan Huoxue Huayu Fang attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-β1/Smad signaling.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Humans; Liver; Liver Cirrhosis; Peanut Oil; Rats; Si | 2022 |
Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Hydro-Lyases; Immunity; Liver; Liver Cirrhosi | 2022 |
Protective role of Siberian onions against toxin-induced liver dysfunction: an insight into health-promoting effects.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Onions; Transam | 2022 |
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fibrosis; Hepatic Stellate Cells; Humans; | 2022 |
Qi Sui Zhu Shui Plaster Inhibits AQP1 and MAPK Signaling Reduces Liver Damage Induced by Cirrhotic Ascites.
Topics: Animals; Aquaporin 1; Ascites; Body Weight; Carbon Tetrachloride; Humans; Liver Cirrhosis; Liver Dis | 2022 |
Preventive effect of isostrictiniin from
Topics: Animals; Candida; Carbon Tetrachloride; I-kappa B Kinase; Liver; Liver Cirrhosis; Mice; NF-kappa B; | 2023 |
S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Dr | 2022 |
6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Catechols; Liver; Liver Cirrhosis; Mice; NF | 2022 |
Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Caspase 3; Cytokines; Dietary Supplements; | 2022 |
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4.
Topics: Animals; Carbon Tetrachloride; Chemokine CCL3; Chemokine CCL4; Fibrosis; Hepatic Stellate Cells; Hya | 2022 |
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Endoplasmic Reticulum Stress; Flavonoids; Glycerophospholi | 2022 |
The combination of experimental periodontitis and oral microbiota from periodontitis patients aggravates liver fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Azo Compounds; Carbon Tetrachloride; Hydroxyproline; Liver Ci | 2022 |
Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain fatty acid and bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Fatty Acids, Volatile; Lignans; Liver; Liver Ci | 2022 |
Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells.
Topics: Actins; Benzopyrans; Butyrates; Carbon Tetrachloride; Collagen Type I; Cyclooxygenase 2; Ferroptosis | 2022 |
Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro.
Topics: Aged; Aging; Animals; Canthaxanthin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Humans; Hydrog | 2022 |
Effect of Iron Deposition on Native T1 Mapping and Blood Oxygen Level Dependent for the Assessment of Liver Fibrosis in Rabbits With Carbon Tetrachloride Intoxication.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Magnetic Resonance Imaging; Oxygen Saturation | 2023 |
Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Lysine; Male; Rats; Rats, Sprague-Dawley; Sor | 2022 |
Mechanism of dact2 gene inhibiting the occurrence and development of liver fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Catenins; Hepatic Stellate Cell | 2022 |
Drug response biomarkers of Pien Tze Huang treatment for hepatic fibrosis induced by carbon tetrachloride.
Topics: Animals; Biomarkers, Pharmacological; Carbon Tetrachloride; Drugs, Chinese Herbal; Liver Cirrhosis; | 2022 |
Activin B promotes the initiation and progression of liver fibrosis.
Topics: Activins; Adenosine Diphosphate; Animals; Carbon Tetrachloride; Humans; Liver Cirrhosis; Mice; Nitri | 2022 |
Cellular communication network factor 1-stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Integrins; Kupffer Cells; Liver Cirrhosis; Mi | 2022 |
Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Collagen; Collagen Type I; Commiphora; Hepatic Stellate Cells; Liver; | 2022 |
Identification of circular RNA biomarkers for Pien Tze Huang treatment of CCl4‑induced liver fibrosis using RNA‑sequencing.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Case-Control Studies; Drugs, C | 2022 |
[Study of the negative regulation of transforming growth factor beta type II receptor to inhibit the occurrence and development of liver fibrosis with miR-217].
Topics: Actins; Angiotensin II; Animals; Carbon Tetrachloride; Collagen Type I; Hepatic Stellate Cells; Live | 2022 |
Olmesartan Improves Hepatic Sinusoidal Remodeling in Mice with Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Angiotensin II; Animals; Carbon Tetrachloride; Collagen; Imidazoles; Interleukin-10; Liver Cirrhosis | 2022 |
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway.
Topics: Animals; Carbon Tetrachloride; Casein Kinase II; Fibrosis; Hedgehog Proteins; Hepatic Stellate Cells | 2023 |
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cytokines; Drugs, Chinese Herbal; Liver; Liver Cirrhosi | 2022 |
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Gastrointestinal Microbiome; Lithocholic Ac | 2022 |
miR-345-5p curbs hepatic stellate cell activation and liver fibrosis progression by suppressing hypoxia-inducible factor-1alpha expression.
Topics: 3' Untranslated Regions; Animals; Carbon Tetrachloride; Cell Proliferation; Fibrosis; Hepatic Stella | 2022 |
Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Dis | 2022 |
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
Topics: Animals; Bleomycin; Carbon Tetrachloride; Fibrosis; Galectin 3; Idiopathic Pulmonary Fibrosis; Liver | 2022 |
Neurotrophic factors stimulate the activation of hepatic stellate cells in liver fibrosis.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbon Tetrachloride; Cytokines; Fibrosis; Glial Fibrill | 2022 |
LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Endothelial Cells; Humans; Kruppel-Like Transcription Fac | 2022 |
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Topics: Acetylglucosamine; Animals; Biomimetic Materials; Carbon Tetrachloride; Desmin; Hepatic Stellate Cel | 2023 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Topics: Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrac | 2022 |
Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl
Topics: Albumins; Animals; Antioxidants; Bilirubin; Cadherins; Carbon Tetrachloride; Epithelial-Mesenchymal | 2022 |
Carthami flos extract against carbon tetrachloride-induced liver fibrosis via alleviating angiogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Helianthus; Hepatic Stellate Cells; Liver; Liver Cirrhosis; | 2023 |
Enhanced Expression of ARK5 in Hepatic Stellate Cell and Hepatocyte Synergistically Promote Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Hepatocytes; Liver; Liver Cirrhosis; Mice; Re | 2022 |
20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Mice; Signal | 2023 |
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Fibronectins; Hepatic Stellate Cells; Infla | 2022 |
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Signal Transduc | 2023 |
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Signal Transduc | 2023 |
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Signal Transduc | 2023 |
An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signalling.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Signal Transduc | 2023 |
[Therapeutic effect of Jingfang Granules on CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Animals; Carbon Tetrachloride; Interleukin-6; Liver; Liver Cirrhosis; Male; Mice; Olive Oil; Superox | 2022 |
[Therapeutic effect of Jingfang Granules on CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Animals; Carbon Tetrachloride; Interleukin-6; Liver; Liver Cirrhosis; Male; Mice; Olive Oil; Superox | 2022 |
[Therapeutic effect of Jingfang Granules on CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Animals; Carbon Tetrachloride; Interleukin-6; Liver; Liver Cirrhosis; Male; Mice; Olive Oil; Superox | 2022 |
[Therapeutic effect of Jingfang Granules on CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Animals; Carbon Tetrachloride; Interleukin-6; Liver; Liver Cirrhosis; Male; Mice; Olive Oil; Superox | 2022 |
[Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Glycosides; Hepatic Stellate | 2022 |
[Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Glycosides; Hepatic Stellate | 2022 |
[Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Glycosides; Hepatic Stellate | 2022 |
[Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism].
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Glycosides; Hepatic Stellate | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Topics: Aged; Aging; Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; | 2022 |
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Topics: Aged; Aging; Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; | 2022 |
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Topics: Aged; Aging; Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; | 2022 |
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Topics: Aged; Aging; Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; | 2022 |
Jiawei Taohe Chengqi Decoction attenuates hepatic fibrosis by preventing activation of HSCs through regulating Src/ERK/Smad3 signal pathway.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; MAP Kin | 2023 |
Ivermectin Attenuates CCl
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Ivermectin; Liver; Liver Cirrhosis; Mice; Rat | 2022 |
Miglustat, a glucosylceramide synthase inhibitor, mitigates liver fibrosis through TGF-β/Smad pathway suppression in hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Mice; Mice, I | 2023 |
Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Dietary Fats, Unsaturated; Hepatic Stellate Cells; Liver; Liver Cirrh | 2023 |
Imatinib suppresses activation of hepatic stellate cells by targeting STAT3/IL-6 pathway through miR-124.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Imatinib Mesylate; Interleukin-6; Liver Cirrh | 2023 |
Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-β1/Smad signaling pathway.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Phosphatidylino | 2023 |
Structural Changes in the Liver in Post-Toxic Cirrhosis and Its Treatment with Oxidized Dextran. Immunohistochemical Research.
Topics: Animals; Carbon Tetrachloride; Collagen; Collagen Type I; Dextrans; Liver; Liver Cirrhosis; Rats; Ra | 2023 |
Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Non-alcoholic F | 2023 |
Effect of ADHI on hepatic stellate cell activation and liver fibrosis in mice.
Topics: Alcohol Dehydrogenase; Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatic Stellate Cells | 2023 |
m
Topics: Animals; Carbon Tetrachloride; Circadian Clocks; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Met | 2023 |
Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats.
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Hyaluronic Acid; Liver; Liver Cirrhosis; Male | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla | 2023 |
Mangiferin relieves CCl4-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibrosis; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred | 2023 |
Cell atlas of CCl
Topics: Animals; Carbon Tetrachloride; Cell Communication; Endothelial Cells; Liver Cirrhosis; Mammals; Mice | 2023 |
A herbal product inhibits carbon tetrachloride-induced liver fibrosis by suppressing the epidermal growth factor receptor signaling pathway.
Topics: Carbon Tetrachloride; Drugs, Chinese Herbal; ErbB Receptors; Humans; Liver Cirrhosis; Proteomics; Si | 2023 |
Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Tetrachloride; Hepatocytes; Liver Cirr | 2023 |
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Sirtuin 1; | 2023 |
Glaucocalyxin A attenuates carbon tetrachloride-induced liver fibrosis and improves the associated gut microbiota imbalance.
Topics: Animals; Carbon Tetrachloride; Gastrointestinal Microbiome; Liver; Liver Cirrhosis; Male; Mice; Mice | 2023 |
A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Codonopsis; Humans; Liver; Liver Cirrhosis; Mice; NF-kappa B; Polysac | 2023 |
CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Inflammation; Lipopolysaccharide Receptors; L | 2023 |
HOXC8/TGF-β1 positive feedback loop promotes liver fibrosis and hepatic stellate cell activation via activating Smad2/Smad3 signaling.
Topics: Animals; Carbon Tetrachloride; Feedback; Fibrosis; Hepatic Stellate Cells; Homeodomain Proteins; Hum | 2023 |
E Se tea extract ameliorates CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cytokines; Humans; Liver; Liver Cirrhosis; Mice; NF-E2- | 2023 |
Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Topics: Animals; Carbon Tetrachloride; Diet; Fibrosis; Hepatic Stellate Cells; Humans; Inflammation; Liver; | 2023 |
Fate tracking reveals differences between Reelin
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Desmin; Hepatic Stellate Cells; Liver; Liver Cirr | 2023 |
Mouse Models for Hepatic Stellate Cell Activation and Liver Fibrosis Initiation.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver; Liver | 2023 |
Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Human | 2023 |
Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chromatin Immunoprecipitation; GRB2 Adaptor Protein; Hepatic Stellate | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.
Topics: Animals; Axitinib; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Mitoc | 2023 |
Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Inflammation; Interleukin-6; | 2024 |
Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound.
Topics: Adenosine; Animals; Carbon Tetrachloride; Cytokines; Fibrosis; Inflammation; Liver; Liver Cirrhosis; | 2023 |
Longitudinal Study of Cirrhosis Development in STAM and carbon tetrachloride Mouse Models Using Fourier Transform Infrared Spectral Imaging.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fourier Analysis; Glycogen; Liver Cirrhosis; | 2023 |
An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antioxidants; Antiviral Agents; Carbon Tetrachloride; Hepacivirus; Hepatitis C; Hepatitis C | 2023 |
Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Mice; Neurobl | 2023 |
Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Fibrosis; Glutamate-Cysteine Ligase; Glutat | 2023 |
Effect of mycophenolate mofetil alleviates carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mycophenolic Acid; R | 2023 |
Metabolomics study of the hepatoprotective effect of total flavonoids of Mallotus apelta leaf in carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; China; Flavonoids; Liver Cirrhosis; Mallotus Plant; Metabolomics; Pla | 2023 |
MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway.
Topics: Animals; Carbon Tetrachloride; Fibrillin-1; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Mi | 2023 |
Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Receptor, Trans | 2023 |
Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis.
Topics: ATP-Dependent Proteases; Carbon Tetrachloride; DNA-Binding Proteins; DNA, Mitochondrial; Humans; Liv | 2023 |
Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Autophagy; Body Weight; Carbon Tetrachloride; Liver Cirrhosis; Lycopene; Male; NF-kappa B; | 2023 |
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosi | 2023 |
Therapeutic Effects of Albumin-Fused BMP7 on 2 Experimental Models of Liver Fibrosis.
Topics: Albumins; Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Hydroxyproline; Liver; Liver | 2023 |
Hepatocyte survival and proliferation by fibroblast growth factor 7 attenuates liver inflammation, and fibrogenesis during acute liver injury via paracrine mechanisms.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Collagen; Culture Media, Conditioned; Fibroblast | 2023 |
Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Collagen; Cytokines; Fibrosis; Flavonoids; Flavonols; K | 2023 |
ADAMTS12 is a stromal modulator in chronic liver disease.
Topics: ADAMTS Proteins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatic Stellate Cells; Humans; Li | 2023 |
Kaempferol attenuates carbon tetrachloride (CCl
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Kaempferols; Liver; Liver Cirrhosis; Molecula | 2023 |
TMT-based proteomics analysis identifies the interventional mechanisms of Qijia Rougan decoction in improving hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Plant Extracts; Proteomics; Rats; Signal Tran | 2024 |
Sodium alginate combined with oxymatrine ameliorates CCl
Topics: Alginates; Alkaloids; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Mice; Rats; Rats, Sprag | 2023 |
Hyperoside attenuates carbon tetrachloride-induced hepatic fibrosis via the poly(ADP-ribose)polymerase-1-high mobility group protein 1 pathway.
Topics: Adenosine Diphosphate Ribose; Animals; Carbon Tetrachloride; HMGB1 Protein; Inflammation; Liver Cirr | 2023 |
Triptolide attenuates CCL
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Liver; Liver Cirrhosis; Mice; T-Lymphocytes, Re | 2023 |
Sex Drives Functional Changes in the Progression and Regression of Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Female; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Mice; P | 2023 |
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis; | 2023 |
Inhibitory effects of
Topics: Animals; Bilirubin; Carbon; Carbon Tetrachloride; Liver; Liver Cirrhosis; Mice; Oxidative Stress | 2024 |
Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway.
Topics: Animals; Carbon Tetrachloride; Crocus; Fibrosis; Hepatic Stellate Cells; Inflammation; Liver; Liver | 2023 |
Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis.
Topics: Animals; Atorvastatin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Drug Evaluatio | 2019 |
Praziquantel ameliorates CCl
Topics: Animals; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Gene Expression; Hepatic Stellate | 2019 |
Antler stem cells as a novel stem cell source for reducing liver fibrosis.
Topics: Actins; Animals; Antlers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Collagen; | 2020 |
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Doc | 2019 |
Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl
Topics: Animals; Calcitriol; Calcium; Carbon Tetrachloride; Cell Line; Drug Evaluation, Preclinical; Ergocal | 2019 |
Hesperetin derivative attenuates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; C | 2019 |
Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Corn Oil; Dietary | 2019 |
Dahuang Zhechong pill attenuates CCl4-induced rat liver fibrosis via the PI3K-Akt signaling pathway.
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Gene Expression Regulation; Liver Cirrhosis; M | 2020 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li | 2019 |
Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Cin | 2019 |
Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow; Carbon Tetrachloride; Cell | 2019 |
Icariin-induced miR-875-5p attenuates epithelial-mesenchymal transition by targeting hedgehog signaling in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Disease Models, Animal; Epithelial-Mesench | 2020 |
Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Topics: Animals; Biopsy; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Gene Expression Regulation | 2020 |
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Kupffer Cells | 2020 |
Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Actins; Animals; Carbon Tetrachloride; Cell Line; | 2020 |
MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon Tetrachloride; Endoth | 2019 |
Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Cell Proliferation; Down-Regu | 2020 |
Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Male; Mice, Inbred C57BL; TRPV Cation Channel | 2019 |
Mediator MED23 regulates inflammatory responses and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemokine CCL5; Chemokine CXCL10; Disease Models, Animal; | 2019 |
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice.
Topics: Aminopyridines; Animals; Bile Ducts; Carbon Tetrachloride; Hepatic Stellate Cells; I-kappa B Kinase; | 2020 |
Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis.
Topics: Animals; Capillaries; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herbal; Endotheli | 2019 |
Hepatoprotective effect of a fucoidan extract from Sargassum fluitans Borgesen against CCl
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Gene Expressi | 2020 |
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury, Ch | 2020 |
Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line; Connective Tissue Growth F | 2020 |
Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Image Processing, Computer-Assisted; Inflamma | 2020 |
Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Early Diagnosis; Humans; Liver; Liver Cirrhos | 2019 |
Daclatasvir and Sofosbuvir Mitigate Hepatic Fibrosis Through Downregulation of TNF-α / NF-κB Signaling Pathway.
Topics: Animals; Carbamates; Carbon Tetrachloride; Disease Progression; Down-Regulation; Hepatic Stellate Ce | 2020 |
AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF-β/Smad Signaling Pathway in Rats.
Topics: Animals; Anti-Infective Agents; Carbon Tetrachloride; Eugenol; Liver Cirrhosis; Male; Mesenchymal St | 2020 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Down-Regulation; | 2020 |
Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Progression; Hepatic Stellate Cells; Humans; | 2020 |
A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Hepatic Stellate Cells; Hum | 2020 |
Hepatoprotective effect of total flavonoids of Mallotus apelta (Lour.) Muell.Arg. leaf against carbon tetrachloride-induced liver fibrosis in rats via modulation of TGF-β1/Smad and NF-κB signaling pathways.
Topics: Animals; Carbon Tetrachloride; Collagen; Cytokines; Flavonoids; Lipid Peroxidation; Liver; Liver Cir | 2020 |
Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Liver Cir | 2020 |
Transcriptomics and proteomics analysis of system-level mechanisms in the liver of apigenin-treated fibrotic rats.
Topics: Alanine Transaminase; Albumins; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Apigenin; A | 2020 |
Adenovirus Biodistribution is Modified in Sensitive Animals Compared to Naïve Animals.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Cyclosporine; Genetic Therapy; Immunization; Immunosupp | 2020 |
Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.
Topics: Animals; Biopsy; Capillaries; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2020 |
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Gene Expression Regulation; Gene Knockdown Techniques; Gly | 2020 |
Immunomodulatory effect of curcumin on hepatic cirrhosis in experimental rats.
Topics: Animals; Carbon Tetrachloride; Curcumin; Immunity; Liver Cirrhosis; Rats | 2020 |
Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome.
Topics: Animals; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Diterpenes, Kaurane; Hepatic Stell | 2020 |
Increased Purinergic Responses Dependent on P2Y2 Receptors in Hepatocytes from CCl
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Hepatocy | 2020 |
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Topics: Alginates; Animals; Autophagy; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Down-Regula | 2020 |
[Anti-fibrotic mechanism of Sedum sarmentosum total flavanones in inhibiting activation of HSC by regulating Smads].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Flavanones; Hepatic Stellate Cells; Liver; Liv | 2020 |
Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling.
Topics: Alginates; Animals; Carbon Tetrachloride; Cell Line; Cell Movement; Cell Proliferation; Cell Surviva | 2020 |
LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals.
Topics: Aldehyde Oxidoreductases; Animals; Artemisinins; Carbon Tetrachloride; Cell Line; Gene Knockdown Tec | 2020 |
RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines.
Topics: Animals; Carbon Tetrachloride; Cytokines; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; | 2020 |
Dynamic contrast-enhanced MRI with Gd-EOB-DTPA for the quantitative assessment of early-stage liver fibrosis induced by carbon tetrachloride in rabbits.
Topics: Animals; Carbon Tetrachloride; Contrast Media; Gadolinium DTPA; Liver Cirrhosis; Magnetic Resonance | 2020 |
Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferation In Vitro and Therapeutic Abilities in Rat Hepatic Fibrosis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bilirubin; Carbon Tetrachloride; C | 2020 |
Comparative study on effect of mesenchymal stem cells and endothelial progenitor cells on treatment of experimental CCL4-induced liver fibrosis.
Topics: Albumins; Animals; Carbon Tetrachloride; Endothelial Progenitor Cells; Liver Cirrhosis; Matrix Metal | 2022 |
Huagan tongluo Fang improves liver fibrosis via down-regulating miR-184 and up-regulating FOXO1 to inhibit Th17 cell differentiation.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cell Differentiation; Disease Models, Animal; Down-Reg | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic | 2020 |
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carbon Tetrachloride; Disease Mode | 2020 |
Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Male; Mesenchymal Ste | 2021 |
Camellia oil (Camellia oleifera Abel.) attenuates CCl
Topics: Animals; Apoptosis; Camellia; Carbon Tetrachloride; Disease Models, Animal; Hepatocytes; Liver Cirrh | 2020 |
Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis; Mice; Mice, Knockout; Micros | 2020 |
Pelargonidin ameliorates CCl
Topics: Actins; Animals; Anthocyanins; Carbon Tetrachloride; Cell Line; Collagen; Hepatic Stellate Cells; Hu | 2020 |
PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β-catenin signalling pathway.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle Proteins; Cell Line; Cell Proliferation; Hepati | 2020 |
Synergistic antifibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cell Line; Down-Regulation; Exportin 1 Protein; HEK293 | 2020 |
Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride-induced liver fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Estrogen Receptor beta; Isoflavones; Janus K | 2021 |
Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Carbon Tetrachloride; Disease | 2020 |
ROS-dependent inhibition of the PI3K/Akt/mTOR signaling is required for Oroxylin A to exert anti-inflammatory activity in liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Cytokines; Flavonoids; Hep | 2020 |
Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male | 2020 |
Therapeutic potential of bone marrow-derived mesenchymal stem cells and imatinib in a rat model of liver fibrosis.
Topics: Animals; Bone Marrow; Carbon Tetrachloride; Combined Modality Therapy; Disease Models, Animal; Imati | 2020 |
Senolytic CAR T cells reverse senescence-associated pathologies.
Topics: Adenocarcinoma; Aging; Animals; Carbon Tetrachloride; Cellular Senescence; Female; Heterografts; Hum | 2020 |
hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis.
Topics: Animals; Benzofurans; Biomarkers; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cu | 2020 |
The small heterodimer partner inhibits activation of hepatic stellate cells via autophagy.
Topics: Animals; Autophagy; Carbon Tetrachloride; Hepatic Stellate Cells; Liver Cirrhosis; Rats; Tissue Inhi | 2020 |
Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Movement; Hepatic Stellate Cells; Liv | 2020 |
Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice.
Topics: Animals; Apoptosis; Biopsy; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2020 |
MicroRNA-503 Targets Mothers Against Decapentaplegic Homolog 7 Enhancing Hepatic Stellate Cell Activation and Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver Cirrhosis; MicroRNAs; Rats; Rat | 2021 |
Gut Microbiota and Liver Fibrosis: One Potential Biomarker for Predicting Liver Fibrosis.
Topics: Animals; Bacteria; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Feces; Gastrointestinal | 2020 |
Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Chemical and Drug Induced Liver Injury; Disease Models | 2020 |
Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation.
Topics: Actins; Angiotensin II; Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Cells, Cul | 2020 |
Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2020 |
LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.
Topics: Aged; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Down-Regulation; Female; Hepatic | 2020 |
Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Cells, Cultured; Collag | 2020 |
Intravenous Umbilical Cord-derived Mesenchymal Stem Cells Transplantation Regulates Hyaluronic Acid and Interleukin-10 Secretion Producing Low-grade Liver Fibrosis in Experimental Rat.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fetal Blood; Hyaluronic Acid; Interleukin-10; | 2020 |
Ameliorative effects of Qingganjiuwei powder, a traditional Mongolian medicine, against CCl
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Liver Cirrhosis; Male; Medicine, Mongolian Tra | 2021 |
Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Disease Sus | 2020 |
Mesenchymal stem cells ameliorate oxidative stress, inflammation, and hepatic fibrosis via Nrf2/HO-1 signaling pathway in rats.
Topics: Animals; Carbon Tetrachloride; Inflammation; Liver; Liver Cirrhosis; Mesenchymal Stem Cells; NF-E2-R | 2021 |
The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Regulatory Networks; Genetic Predisposit | 2021 |
Effect of Human Umbilical Cord Mesenchymal Stem Cells Transfected with HGF on TGF-β1/Smad Signaling Pathway in Carbon Tetrachloride-Induced Liver Fibrosis Rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Hepatocyte Growth Factor; Humans; Infant, Newborn; | 2020 |
Tyrosine kinase inhibitor neratinib attenuates liver fibrosis by targeting activated hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Fibroblast Growth Factor 2; Hepatic Stellate Cell | 2020 |
Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Cells, Cultured; Follistatin-Related Protei | 2020 |
Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Anim | 2020 |
Fibroblast growth factor 2 conjugated superparamagnetic iron oxide nanoparticles (FGF2-SPIONs) ameliorate hepatic stellate cells activation in vitro and acute liver injury in vivo.
Topics: Carbon Tetrachloride; Fibroblast Growth Factor 2; Hepatic Stellate Cells; Humans; Liver; Liver Cirrh | 2020 |
Silencing p53 inhibits interleukin 10-induced activated hepatic stellate cell senescence and fibrotic degradation in vivo.
Topics: Animals; Carbon Tetrachloride; Cellular Senescence; Gene Silencing; Hepatic Stellate Cells; Interleu | 2021 |
Radiomics Approaches for Predicting Liver Fibrosis With Nonenhanced T
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Neoplasms; Prospective Studies; Rats; Rats, Wi | 2021 |
Dietary fiber regulates intestinal flora and suppresses liver and systemic inflammation to alleviate liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Dietary Fiber; Gastrointestinal Microbiome; Inflammation; Liver; Live | 2021 |
Therapeutic effect of uridine phosphorylase 1 (UPP1) inhibitor on liver fibrosis in vitro and in vivo.
Topics: Animals; Carbon Tetrachloride; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhi | 2021 |
Tanshinone IIA exerts therapeutic effects by acting on endogenous stem cells in rats with liver cirrhosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease Models, | 2020 |
β-Arrestin2 deficiency attenuates oxidative stress in mouse hepatic fibrosis through modulation of NOX4.
Topics: Animals; beta-Arrestin 2; Carbon Tetrachloride; Collagen; Down-Regulation; Gene Knockout Techniques; | 2021 |
MicroRNA-125a/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis.
Topics: Animals; Antagomirs; Autophagy; Base Sequence; Carbon Tetrachloride; Dependovirus; Disease Models, A | 2021 |
Comparing distress of mouse models for liver damage.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Diseases; Mice | 2020 |
AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.
Topics: Adenylate Kinase; Alanine Transaminase; Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Model | 2020 |
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl
Topics: Animals; Carbon Tetrachloride; DNA Damage; DNA Repair; Genomics; Hep G2 Cells; Humans; Liver Cirrhos | 2020 |
Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chlorella vulgaris; Gene Expression Regulatio | 2021 |
Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC).
Topics: Animals; Calcium-Binding Proteins; Carbon Tetrachloride; Cell Line; Hepatic Stellate Cells; Histidin | 2021 |
Transcriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells.
Topics: Activating Transcription Factor 3; Animals; Carbon Tetrachloride; Cells, Cultured; Feedback, Physiol | 2020 |
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis.
Topics: Animals; Capillaries; Carbon Tetrachloride; Endothelial Cells; Gene Expression Regulation; Liver Cir | 2021 |
Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice.
Topics: Animals; Cannabis; Carbon Tetrachloride; Diet, High-Fat; Dronabinol; Gene Expression Regulation; Hep | 2021 |
sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p.
Topics: Animals; Carbon Tetrachloride; Coculture Techniques; Extracellular Vesicles; Gene Expression Regulat | 2021 |
Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cell Proliferati | 2020 |
[Component analysis of Ophiocordyceps lanpingensis polysaccharides and study on alleviation of hepatic fibrosis in mice by polysaccharides].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Hypocreales; Liver | 2020 |
Transforming Growth Factor Beta-Induced Foxo3a Acts as a Profibrotic Mediator in Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mice; Transforming G | 2021 |
Extracellular histones stimulate collagen expression
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Histones; Liver; Liver Cirrhosis; Male; Mice; | 2020 |
A role for intestinal alkaline phosphatase in preventing liver fibrosis.
Topics: Adult; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Common Bile Duct; Disease Models, Animal | 2021 |
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Topics: Adenosine; Animals; Apoptosis; Benzazepines; Bile Ducts; Carbon Tetrachloride; Cell Cycle; Cell Cycl | 2021 |
The Effect of Lecithins Coupled Decorin Nanoliposomes on Treatment of Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Line; Cell Proliferation; Decorin; Lecithins; Liposo | 2020 |
Association of CX3CL1 and CX3CR1 Expression with Liver Fibrosis in a Mouse Model of Schistosomiasis.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dise | 2020 |
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Topics: Animals; Berberine Alkaloids; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Extracellula | 2021 |
Combining
Topics: Animals; Carbon Tetrachloride; Contrast Media; Fluorodeoxyglucose F18; Gadolinium DTPA; Liver Cirrho | 2021 |
[Effect and mechanism of total flavonoids of Lichi Semen on CCl_4-induced liver fibrosis in rats, and prediction of Q-marker].
Topics: Animals; Carbon Tetrachloride; Flavonoids; Liver; Liver Cirrhosis; Male; Molecular Docking Simulatio | 2020 |
Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis.
Topics: Animals; Biopsy; Carbon Tetrachloride; Cell Communication; Cytokines; Disease Susceptibility; Gene D | 2021 |
Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients.
Topics: Angiopoietin-2; Animals; Antiviral Agents; Carbon Tetrachloride; Hepatitis C, Chronic; Humans; Liver | 2021 |
Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis.
Topics: Animals; Capillaries; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver; Liver Ci | 2021 |
Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chlorocebus aethiops; Collagen; Disease Models, Animal | 2021 |
Vitamin E pretreated Wharton's jelly-derived mesenchymal stem cells attenuate CCl
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Coculture Techniques; Hepatocytes; Liver Cirrhosis; | 2021 |
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation.
Topics: Animals; Carbamates; Carbon Tetrachloride; Cell Line; Female; Gene Expression Profiling; Gene Expres | 2021 |
Taxifolin, Extracted from Waste
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachloride; Dose-Response Rel | 2021 |
Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-β/Smad Signaling Pathway.
Topics: Animals; Carbon Tetrachloride; Cell Line; Gene Expression Regulation; Hepatic Stellate Cells; Humans | 2021 |
Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver | 2021 |
5-methoxytryptophan alleviates liver fibrosis by modulating FOXO3a/miR-21/ATG5 signaling pathway mediated autophagy.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cell Line; Cell Survival; Dos | 2021 |
Elevated miR-129-5p attenuates hepatic fibrosis through the NF-κB signaling pathway via PEG3 in a carbon CCl
Topics: Animals; Base Sequence; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Kruppel-Like | 2021 |
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Bile Acids and Salts; Biomarkers; Carbon Tet | 2021 |
Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis.
Topics: Animals; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Cell Line; Di | 2021 |
Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Hepatectomy; Hepatic Stellate Cells; Hepatocytes; | 2021 |
Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Cytokines; Dose-Response Relationship, Drug; Flavonols; Glu | 2021 |
Ligustroflavone ameliorates CCl
Topics: Animals; Apigenin; Carbon Tetrachloride; Glycosides; Hepatic Stellate Cells; Liver; Liver Cirrhosis; | 2021 |
Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice.
Topics: Animals; Carbon Tetrachloride; Chenodeoxycholic Acid; Diet; Inflammation; Liver; Liver Cirrhosis; Ma | 2021 |
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Galactosamine; Hum | 2021 |
Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Cytokines; Disease Models, A | 2021 |
Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Actins; Animals; Becaplermin; Carbon Tetrachloride; Catalase; | 2021 |
Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl
Topics: Animals; Animals, Outbred Strains; Antioxidants; Carbon Tetrachloride; Cells, Cultured; Chemical and | 2021 |
Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Cancer-Associated Fibroblasts; Ca | 2021 |
Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2020 |
Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Exosomes; Female; Gene Expression Regulation; Liver Cirrhosis; Mice; | 2021 |
The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction.
Topics: Amides; Animals; Carbon Tetrachloride; CD24 Antigen; Cells, Cultured; Gene Expression; Hepatic Stell | 2021 |
miR-30c inhibits angiogenesis by targeting delta-like ligand 4 in liver sinusoidal endothelial cell to attenuate liver fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Calcium-Binding Proteins; Carbon Tetrachloride | 2021 |
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Collagen; Disease Models, Ani | 2021 |
Physalin B attenuates liver fibrosis via suppressing LAP2α-HDAC1-mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation.
Topics: Animals; Carbon Tetrachloride; Hedgehog Proteins; Hepatic Stellate Cells; Histone Deacetylase 1; Liv | 2021 |
Investigation of the therapeutic effect of Yinchen Wuling Powder on CCl
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Metabolomics; Powders; | 2021 |
Hepato-protective role of itraconazole mediated cytochrome p450 pathway inhibition in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Female; Hep G2 Cel | 2020 |
Inhibition of the transient receptor potential vanilloid 3 channel attenuates carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdow | 2021 |
RUNX1 regulates SMAD1 by transcriptionally activating the expression of USP9X, regulating the activation of hepatic stellate cells and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cell Survival; Core Binding Factor | 2021 |
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Re | 2021 |
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Estrogen Receptor beta; Inflammasomes; Liver Cirrhos | 2021 |
Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-β2 axis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Gene Expression Regulation; Liver Cirrhosis; Male | 2021 |
Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision-cut liver slices.
Topics: Adenosine Triphosphate; Animals; Blood Vessels; Carbon Tetrachloride; Endothelin-1; Ketanserin; Live | 2021 |
Mouse Models of Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Hepatic Stellate Cells; Human | 2021 |
Age-Related Features of the Response of the Liver and Stem Cells during Modeling of Liver Cirrhosis.
Topics: Animals; Carbon Tetrachloride; Endothelial Cells; Hepatocytes; Liver; Liver Cirrhosis; Male; Mesench | 2021 |
Ethyl Acetate Fraction of Dicliptera chinensis (L.) Juss. Ameliorates Liver Fibrosis by Inducing Autophagy via PI3K/AKT/mTOR/p70S6K Signaling Pathway.
Topics: Acetates; Animals; Autophagy; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; | 2022 |
Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells.
Topics: Animals; Capillaries; Carbon Tetrachloride; Disease Models, Animal; Endothelial Cells; Fatty Acid-Bi | 2021 |
The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Epigenesis, Genetic; Gene Expression R | 2021 |
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cells, Cultured; Exocytosis; Hepatic Stellate Cells; Hepat | 2021 |
The mechanism research on the anti-liver fibrosis of emodin based on network pharmacology.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspases; Emodin; Hepatic Stellate Cells; Humans; Liver Ci | 2021 |
Elucidation of spleen elasticity and viscosity in a carbon tetrachloride rat model of liver cirrhosis using a new ultrasound elastography.
Topics: Animals; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Liver; Liver Cirrhosis; Ra | 2021 |
Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome.
Topics: Amino Acid Transport System y+; Animals; Apoptosis; Auranofin; Carbon Tetrachloride; Cells, Cultured | 2021 |
Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways.
Topics: AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Diet, High-Fat; Liver; Liver Cirrhosis | 2021 |
ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6.
Topics: Animals; Autoantigens; Bleomycin; Carbon Tetrachloride; Cells, Cultured; Collagen; Endoplasmic Retic | 2021 |
Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help.
Topics: Animals; Carbon Tetrachloride; Contrast Media; Gadolinium; Gadolinium DTPA; Liver; Liver Cirrhosis; | 2021 |
A triterpenoid-enriched extract of bitter melon leaves alleviates hepatic fibrosis by inhibiting inflammatory responses in carbon tetrachloride-treated mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrach | 2021 |
Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Drug Carriers; Gene Silencing; Heterocyclic Compounds; Hum | 2021 |
Staging Liver Fibrosis: Comparison of Native T1 Mapping, T2 Mapping, and T1ρ: An Experimental Study in Rats With Bile Duct Ligation and Carbon Tetrachloride at 11.7 T MRI.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Liver; Liver Cirrhosis; Magnetic Resonance Imaging; Prosp | 2022 |
[Study on mechanism of salidroside against liver fibrosis by regulating CXCL16].
Topics: Animals; Carbon Tetrachloride; Chemokine CXCL16; Glucosides; Hepatic Stellate Cells; Liver; Liver Ci | 2021 |
Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.
Topics: Animals; Carbon Tetrachloride; Caspase 1; Collagen; Eosine Yellowish-(YS); Hematoxylin; Inflammasome | 2022 |
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Drugs, Chinese Herbal; Hepatic | 2021 |
Targeted truncated TGF-β receptor type II delivery to fibrotic liver by PDGFβ receptor-binding peptide modification for improving the anti-fibrotic activity against hepatic fibrosis in vitro and in vivo.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Genetic Vectors; Liver Cirrhosis; Mice; Peptides; R | 2021 |
Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Susceptibility; | 2021 |
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cell L | 2021 |
Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow Cells; Carbon Tetrachloride; | 2017 |
EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Enhancer of Zeste Hom | 2017 |
Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 - induced liver fibrotic rat.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hepatocytes; Liver Cirrhosis; Male; Molec | 2017 |
Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.
Topics: Activins; Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; | 2017 |
Highly Selective Targeting of Hepatic Stellate Cells for Liver Fibrosis Treatment Using a d-Enantiomeric Peptide Ligand of Fn14 Identified by Mirror-Image mRNA Display.
Topics: Animals; Carbon Tetrachloride; Cell Line; Curcumin; Endocytosis; Hepatic Stellate Cells; Humans; Lip | 2017 |
Antifibrotic effects of tanshinol in experimental hepatic fibrosis by targeting PI3K/AKT/mTOR/p70S6K1 signaling pathways.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Caffeic Ac | 2017 |
Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, | 2017 |
Metformin mitigates carbon tetrachloride-induced TGF-β1/Smad3 signaling and liver fibrosis in mice.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Collagen Type I; Heme Oxygenase-1; Hepatic Stel | 2017 |
Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; bcl-2-Associated X Protein | 2017 |
Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Epithelial-Mesench | 2017 |
Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Diethylcarbamazine; Down-Regulat | 2018 |
Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Hydroxyproline; Liver Cirrhosis; Male; Melatonin; | 2017 |
Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferatio | 2017 |
The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Mice; | 2017 |
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; | 2017 |
Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.
Topics: Adult; Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Down-Regulation; Female; He | 2017 |
Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
Topics: Adult; Animals; Carbon Tetrachloride; Case-Control Studies; Diet, High-Fat; Female; Fibronectins; Ge | 2017 |
Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Actins; Albumins; Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Dose-Response Relationship | 2017 |
Liver cirrhosis reversion is improved in hamsters with a neurointermediate pituitary lobectomy.
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Cricetinae; Hypophysectomy; Liver Cirrhosis; Li | 2017 |
Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Remodeling | 2017 |
Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, | 2017 |
Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carbon Tetrachloride; Inflammation | 2017 |
Targeting CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Cyclin E; Genetic Therapy; Hepatic Ste | 2017 |
MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Communication; Cell Cycle; Cell Differentiation; | 2017 |
Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Induced Li | 2017 |
Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Culture Media, | 2017 |
Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice.
Topics: Animals; Antigens, Ly; Apoptosis; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Cellular Mic | 2017 |
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; Matrix Metalloproteinases; NF-kappa B; Pyruvat | 2018 |
Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton's jelly mesenchymal stromal cells.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Disease Models, Animal; Epithelial Cell | 2017 |
Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Diffe | 2017 |
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi | 2017 |
Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice.
Topics: Aldehydes; Animals; Carbon Tetrachloride; Female; Gene Expression Regulation; Glucosides; Liver; Liv | 2017 |
Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis.
Topics: Amino Acids; Ammonia; Animals; Biomarkers; Carbon Tetrachloride; Eosine Yellowish-(YS); Gas Chromato | 2017 |
Bone marrow endothelial progenitor cells activate hepatic stellate cells and aggravate carbon tetrachloride induced liver fibrosis in mice via paracrine factors.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultured; Coculture Techniques; Culture Med | 2017 |
4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endocanna | 2017 |
Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Inf | 2017 |
Cyanidin-3-O-β-glucoside combined with its metabolite protocatechuic acid attenuated the activation of mice hepatic stellate cells.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cultured; Dru | 2017 |
Evaluation of liver fibrosis using Raman spectroscopy and infrared thermography: A pilot study.
Topics: Animals; Carbon Tetrachloride; Discriminant Analysis; Disease Models, Animal; Drug Dosage Calculatio | 2017 |
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Endotoxins; Gastrointestinal Micro | 2017 |
MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.
Topics: Actins; Animals; Autophagy; Beclin-1; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Cell Line; Col | 2017 |
MiR-29a and miR-652 Attenuate Liver Fibrosis by Inhibiting the Differentiation of CD4+ T Cells.
Topics: Animals; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Li | 2017 |
Schisandrin B attenuates CCl
Topics: Animals; Carbon Tetrachloride; Cyclooctanes; Lignans; Liver Cirrhosis; Male; Molecular Structure; NF | 2017 |
Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress.
Topics: Actins; Animals; Carbon Tetrachloride; CD11b Antigen; Cell Separation; Cell- and Tissue-Based Therap | 2017 |
A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type IV; Disease Models, Animal; Glutamate-Ammonia L | 2017 |
Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Benzopyrans; Camellia sinensis; Carbon Tetrachloride; Disease Models, Animal; Humans; Liver | 2017 |
Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Liver Cir | 2017 |
Evaluation of Rumex hastatus leaves against hepatic fibrosis: a rat model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2017 |
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
Topics: Adaptor Proteins, Signal Transducing; Angiopoietin-2; Animals; Carbon Tetrachloride; Cell Cycle Prot | 2018 |
Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Mediates Liver Fibrosis in Transgenic Mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Gene Expression Regulation, Neoplastic; Heparin-binding EGF | 2017 |
Hepatoprotective effects of Yulangsan flavone against carbon tetrachloride (CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; China; Drugs, Chinese Herbal; | 2017 |
Development of a peptide-modified siRNA nanocomplex for hepatic stellate cells.
Topics: Animals; Avidin; Biotin; Carbon Tetrachloride; Cells, Cultured; Cholesterol; Drug Delivery Systems; | 2018 |
[Research ontherapeutics effect of extract of Ornithogalum caudatum on liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Ornithogalum; Plant E | 2016 |
Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell | 2017 |
Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix; Fibrillar Collagens; Im | 2017 |
[Protective effect and mechanism of total lignans from Tibetan medicinal Herpetospermum seeds on carbon tetrachloride-induced liver fibrosis in rats].
Topics: Animals; Carbon Tetrachloride; Cucurbitaceae; Lignans; Liver; Liver Cirrhosis; Male; Rats; Rats, Spr | 2017 |
Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Drug Liberation; Hepatic Stellate Cells; Imatinib Mesylate; Liposomes | 2017 |
Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats.
Topics: Animals; Benzoates; Carbon Tetrachloride; Disease Models, Animal; Epoxide Hydrolases; Hypertension, | 2018 |
Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrachloride; Cell Line; Cyclin D1; Cyclin E; | 2017 |
Changes in hydrogen sulfide in rats with hepatic cirrhosis in different stages.
Topics: Animals; Carbon Tetrachloride; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Model | 2017 |
Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride‑induced liver fibrosis using serum metabonomics based on gas chromatography‑time of flight mass spectrometry.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Discriminant Analysis; Drugs, Chinese Herbal; Gas Chromat | 2017 |
Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2.
Topics: 3' Untranslated Regions; Actins; Adult; Animals; Antagomirs; Base Sequence; Carbon Tetrachloride; Ce | 2017 |
Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Collagen; Disease Models, Anima | 2017 |
Heparanase and macrophage interplay in the onset of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Glucuronidase; Hepatic Stellate Cells; Humans; Liver; Live | 2017 |
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Enhance | 2018 |
PGE
Topics: Animals; Apolipoproteins E; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cell Proliferation; Collage | 2018 |
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Disease Progress | 2017 |
Serum metabonomics study of the hepatoprotective effect of amarogentin on CCl
Topics: Animals; Biomarkers; Carbon Tetrachloride; Discriminant Analysis; Disease Models, Animal; Drugs, Chi | 2018 |
Recombinant truncated TGF‑β receptor II attenuates carbon tetrachloride‑induced epithelial‑mesenchymal transition and liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellu | 2018 |
Xia-Yu-Xue Decoction Inhibits Intestinal Epithelial Cell Apoptosis in CCl4-Induced Liver Fibrosis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Carbon Tetrachloride; C | 2017 |
FOXA2 alleviates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene | 2017 |
Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy.
Topics: Adenine; Alkaloids; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X P | 2017 |
Fate tracing of hepatocytes in mouse liver.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Epithelial-Mesenchymal Transition; Hepatic Stel | 2017 |
Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Carbon Tetrachloride; Drug Eva | 2018 |
Enhanced efficacy of curcumin with phosphatidylserine-decorated nanoparticles in the treatment of hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Curcumin; Hepatocyte Growth Factor; Liver; Liver Cirrhosis; Macrophag | 2018 |
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytokines; E | 2017 |
Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cytokines; Disease Models, Animal; Gene Express | 2018 |
The role of AdipoR1 and AdipoR2 in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; | 2018 |
Antifibrotic effects of D-limonene (5(1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Cyclohexenes; Glutathione; Li | 2018 |
Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Cytokines; Hepatic Stellate Cells; Humans; Hypoxia-I | 2018 |
Arkadia protein expression is reduced in the liver during the progression of hepatic fibrosis.
Topics: Adult; Animals; Bile Ducts; Carbon Tetrachloride; Disease Progression; Female; Humans; Ligation; Liv | 2018 |
Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl
Topics: Antioxidants; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Q | 2018 |
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Extrac | 2017 |
MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male | 2018 |
Curcumin-Zein Nanospheres Improve Liver Targeting and Antifibrotic Activity of Curcumin in Carbon Tetrachloride-Induced Mice Liver Fibrosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Curcumin; Drug Delivery Systems; Liver; Liver Cirrhosis | 2016 |
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Topics: Acetaminophen; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Female; Hematopoietic Stem | 2019 |
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Topics: Animals; Carbon Tetrachloride; Cell Line; Inflammation; Liver; Liver Cirrhosis; Male; Metalloendopep | 2018 |
Renin-angiotensin system inhibition ameliorates CCl
Topics: Actins; Alanine Transaminase; alpha-Fetoproteins; Animals; Carbon Tetrachloride; Gene Expression Reg | 2018 |
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
Topics: Animals; Benzoates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transdiffere | 2018 |
Systemic inhibition of BMP1-3 decreases progression of CCl
Topics: Actins; Animals; Antibodies; Bone Morphogenetic Proteins; Carbon Tetrachloride; Cell Line; Collagen | 2017 |
Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury.
Topics: Animals; Blood Platelets; Carbon Tetrachloride; Collagen; Hepatic Stellate Cells; Liver; Liver Cirrh | 2018 |
Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultured; Enzyme-Linked Immunosorbent Assay | 2018 |
SENP2 alleviates CCl
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Lin | 2018 |
Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro.
Topics: Acetylation; Animals; Apoptosis; Binding Sites; Biomarkers; Carbon Tetrachloride; CCAAT-Enhancer-Bin | 2018 |
Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen Type IV; | 2018 |
Cav-1 deficiency promotes liver fibrosis in carbon tetrachloride (CCl
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Caveolin 1 | 2018 |
Reparative Effects of Astaxanthin-Hyaluronan Nanoaggregates against Retrorsine-CCl₄-Induced Liver Fibrosis and Necrosis.
Topics: Animals; Carbon Tetrachloride; Hyaluronic Acid; Liver Cirrhosis; Liver Diseases; Male; Necrosis; Pyr | 2018 |
MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition.
Topics: 3' Untranslated Regions; Actins; Animals; Antagomirs; Base Sequence; Cadherins; Carbon Tetrachloride | 2018 |
Effect of histone deacetylase inhibitor on epithelial-mesenchymal transition of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Epithelial-Mesenchymal Transition; Hepatic Stellate | 2018 |
Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats.
Topics: Animals; Carbon Tetrachloride; Isothiocyanates; Kupffer Cells; Liver Cirrhosis; Male; Protective Age | 2018 |
Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis.
Topics: Animals; Bile Ducts; Blood Glucose; Body Weight; Carbon Tetrachloride; Cytokines; Hepatocytes; Infla | 2018 |
The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Hypoxia; Cell Line, Tumor; Eplerenone; HEK293 Cells; Hepatocytes | 2018 |
Asiatic acid attenuates CCl
Topics: Actins; Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrachloride; Caspase 3; Hepatocytes; | 2018 |
Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration.
Topics: Animals; Autophagy; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Caveolin 1; Endothelial Ce | 2018 |
Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Celecoxib; Collagen; Cycloox | 2018 |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 2018 |
[Effects of pirfenidone on hepatic fibrosis in mice induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Pyridones | 2016 |
Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 2018 |
Thymosin β4 suppresses CCl
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Dependovirus; Down-Regulation; Gene Expression Re | 2018 |
Protective effects of Liuweiwuling tablets on carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Humans; Liver Cirrhosis; Male; Rats; Rats, Spr | 2018 |
Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Connexins; Disease Models, Animal; Gene Expression Regula | 2018 |
Investigation of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced liver fibrosis in rats by
Topics: Animals; Carbon Tetrachloride; Corydalis; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Male; Me | 2018 |
PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.
Topics: 5' Untranslated Regions; Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carbon Tetrachlo | 2018 |
Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Emodin; Epithelial-Mese | 2018 |
Therapeutic effect of chitosan on CCl4‑induced hepatic fibrosis in rats.
Topics: Actins; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferas | 2018 |
Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Chemokine CCL2; Collagen Type I; Collagen Type I, alpha 1 Cha | 2019 |
Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cyclin D1; Hepatic Stellate Cells; Hum | 2018 |
Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl₄-Induced Hepatic Fibrosis Animal Model.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Disease Models, Animal; Epithelial-Mesenchymal Transit | 2018 |
Treatment Efficiency of Different Routes of Bone Marrow-Derived Mesenchymal Stem Cell Injection in Rat Liver Fibrosis Model.
Topics: Actins; Administration, Intravenous; Animals; Bone Marrow Cells; Carbon Tetrachloride; Connective Ti | 2018 |
Quantitative analysis of susceptibility-weighted magnetic resonance imaging in chronic hepatitis in rats.
Topics: Animals; Carbon Tetrachloride; Diagnosis, Differential; Disease Models, Animal; Evaluation Studies a | 2018 |
[Effect of Jiawei Yinchen Sini Decoction on the Production of Smad7 and CollagenⅠ,Ⅲ in Carbon Tetrachloride Induced Hepatic Fibrosis Model of Mice].
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Laminin; Liv | 2016 |
Integrated profiling of long non-coding RNAs and mRNAs identifies novel regulators associated with liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Liver Cirrhosis; Male; Mice; Mice, Inbred | 2018 |
Protective effects of combined Losartan and Nilotinib on carbon tetrachloride (CCl
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Carbon Tetrachloride; Drug Therapy, Combination; L | 2020 |
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility | 2018 |
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Hepatic Stellate | 2018 |
Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
Topics: Actins; Animals; Calcium; Carbon Tetrachloride; Cell Line; Cell Movement; Disease Models, Animal; Ge | 2018 |
Hepatoprotection of Herpetospermum caudigerum Wall. against CCl
Topics: Animals; Carbon Tetrachloride; Cucurbitaceae; Energy Metabolism; Liver Cirrhosis; Male; Oxidative St | 2019 |
Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferases; | 2018 |
Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway.
Topics: Adiponectin; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; DNA (Cytosine-5-)-Methylt | 2018 |
P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation.
Topics: Animals; Apoptosis; Artemether; Carbon Tetrachloride; Cell Death; Cell Proliferation; Disease Models | 2019 |
Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; | 2018 |
The firing frequency of spontaneous action potentials and their corresponding evoked exocytosis are increased in chromaffin cells of CCl
Topics: Action Potentials; Animals; Calcium Channels; Carbon Tetrachloride; Catecholamines; Chromaffin Cells | 2019 |
H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cell Line; Epithelial-Mesenchymal Transition; Hepatic | 2019 |
Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl
Topics: Aldehydes; Ammonia; Animals; Brain; Carbon Tetrachloride; Cytokines; Inflammation; Liver Cirrhosis; | 2019 |
4 in 1: Antibody-free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers.
Topics: Albumins; Animals; Capillaries; Carbon Tetrachloride; Cell Separation; Cell Survival; Centrifugation | 2019 |
Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Therapy, Combination; Eugenol; Glutathio | 2019 |
Asiatic acid ameliorates CCl
Topics: Animals; Antioxidant Response Elements; Carbon Tetrachloride; I-kappa B Proteins; Janus Kinase 1; Li | 2018 |
Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis.
Topics: Actins; Animals; Atorvastatin; Azepines; Carbon Tetrachloride; Chitosan; Disease Models, Animal; Dru | 2019 |
Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats.
Topics: Actins; Amygdalin; Animals; Apoptosis; Carbon Tetrachloride; Caspases; Collagen Type I; Drugs, Chine | 2019 |
Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein.
Topics: Actins; Animals; Carbon Tetrachloride; Cloning, Molecular; Disease Models, Animal; Down-Regulation; | 2018 |
CDH11 promotes liver fibrosis via activation of hepatic stellate cells.
Topics: Animals; Cadherins; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Humans; Liver Cir | 2019 |
The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cell Line; Epigenesis, Genetic; Gene Regulatory Networks; Hepatic Ste | 2019 |
α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Carbon Tetrachloride; Down-Re | 2019 |
Conversion of Fibroblasts to Hepatocyte-Like Cells In Vivo.
Topics: Animals; Carbon Tetrachloride; Cell Lineage; Cellular Reprogramming; Dependovirus; Disease Models, A | 2019 |
Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Dise | 2019 |
Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl
Topics: Adenoviridae; Animals; Bone Marrow Cells; Carbon Tetrachloride; Disease Models, Animal; Genetic Ther | 2018 |
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Enhancer of Zeste Homolog 2 Protein; Extracellular Matrix | 2019 |
Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice.
Topics: Animals; Antioxidants; Brassica rapa; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2019 |
The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Eukaryotic Initiation Factors; Hepatic Stellate C | 2018 |
Regulation of CCl
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Dental Pulp; Hepatocytes; Humans; Liver Cirrhos | 2019 |
Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis.
Topics: Adenosine Triphosphate; Amino Acids, Branched-Chain; Animals; Body Weight; Carbon Tetrachloride; Dis | 2018 |
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle Proteins; | 2019 |
Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Dise | 2019 |
Ginger potentiates the effects of silymarin on liver fibrosis induced by CCL4: the role of galectin-8.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Drug Synergism; Galectins; Liver; Liver Cirrho | 2019 |
Letter to Editor: Carbon Tetrachloride-Induced Classical Liver Cirrhosis Model: Revisiting the Mode of Action.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Dysbiosis; L | 2019 |
MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.
Topics: Adipogenesis; Animals; Carbon Tetrachloride; Cell Transdifferentiation; Disease Progression; Gene Ex | 2019 |
Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-β1 Pathway.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chenopodium qui | 2019 |
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdown Techniques; H | 2019 |
Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Movement; Collagen Type I; Collagen Type II; E-Selectin; | 2019 |
Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Count; Cells, Cultured; Disease Models, Animal; Gene Exp | 2019 |
d-amino acid modification protects N-Acetyl-seryl-aspartyl-lysyl-proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis.
Topics: Actins; Amino Acids; Angiotensin-Converting Enzyme Inhibitors; Animals; Carbon Tetrachloride; Cell P | 2019 |
Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.
Topics: Animals; Binding Sites; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Down-Regulati | 2019 |
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Carbon Tetrachloride; Disease Models, Animal; Drug | 2018 |
Nicotinamide riboside protects against liver fibrosis induced by CCl
Topics: Acetylation; Animals; Carbon Tetrachloride; E1A-Associated p300 Protein; Gene Expression Regulation; | 2019 |
PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation.
Topics: Acid Sensing Ion Channels; Animals; Calcium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Caspas | 2019 |
Pien-Tze-Huang ameliorates hepatic fibrosis via suppressing NF-κB pathway and promoting HSC apoptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Drugs, Chinese Herbal; Hepatic Stellate Cells; | 2019 |
Vitronectins produced by human cirrhotic liver and CCl
Topics: Animals; Carbon Tetrachloride; Collagen; Glycosylation; Humans; Liver Cirrhosis; Liver Regeneration; | 2019 |
Hepcidin-orchestrated Hemogram and Iron Homeostatic Patterns in Two Models of Subchronic Hepatic injury.
Topics: Animals; Blood Chemical Analysis; Carbon Tetrachloride; Hepcidins; Injections, Intraperitoneal; Inte | 2019 |
Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells.
Topics: Angiogenesis Inducing Agents; Animals; Bone Marrow Cells; Carbon Tetrachloride; Disease Models, Anim | 2019 |
Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Coumarins; Inflammation; Liver | 2019 |
Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; | 2019 |
Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; China; Cichorium intybus; Disease Models, Animal; Ethnicity; Female; | 2019 |
TG101348, a selective JAK2 antagonist, ameliorates hepatic fibrogenesis
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; | 2019 |
Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Cell Cycle Proteins; Cell Line; | 2019 |
Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis.
Topics: Actins; Animals; Base Sequence; Carbon Tetrachloride; Cell Cycle Proteins; Cells, Cultured; Chemokin | 2019 |
Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cyclooctanes; Down-Regulation; Endoplasmic Reticulum Stres | 2019 |
Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats.
Topics: Animals; Anticoagulants; Biomarkers; Blood Platelets; Carbon Tetrachloride; Clopidogrel; Dabigatran; | 2019 |
Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone Marrow Transplantation; Calcium-Binding Proteins | 2019 |
Inhibitory effects of octreotide on the progression of hepatic fibrosis via the regulation of Bcl-2/Bax and PI3K/AKT signaling pathways.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cytokines; Hepatic Stellate Cells; Hum | 2019 |
Combination of CCl
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; | 2019 |
Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Hepatic Stel | 2019 |
Resveratrol improves CCL4-induced liver fibrosis in mouse by upregulating endogenous IL-10 to reprogramme macrophages phenotype from M(LPS) to M(IL-4).
Topics: Animals; Carbon Tetrachloride; Cell Polarity; Inflammation; Interleukin-10; Interleukin-4; Kupffer C | 2019 |
Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2019 |
Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride.
Topics: Animals; Cadherins; Carbon Tetrachloride; Cells, Cultured; Collagen; Extracellular Matrix; Hepatic S | 2019 |
A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues.
Topics: Animals; Carbon Tetrachloride; Cytoplasm; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Infrar | 2019 |
Hepatoprotective effect of ketoconazole in chronic liver injury model.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Death; Chemical and Drug Induced Liver Injury; Disease M | 2019 |
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Topics: Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carbon Tetrachl | 2019 |
The ameliorations of Ganoderma applanatum residue polysaccharides against CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fungal Polysacc | 2019 |
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.
Topics: Angiotensin II; Animals; Bleomycin; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; Cell Li | 2019 |
Effects of beta-hydroxy-beta-methylbutyrate supplementation on skeletal muscle in healthy and cirrhotic rats.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Dietary Supplements; Leucine; Liver; Liv | 2019 |
Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis.
Topics: Animals; Biflavonoids; Carbon Tetrachloride; Catechin; Cell Line; Cell Proliferation; Down-Regulatio | 2019 |
A critical role of autophagy in regulating the mesenchymal transition of ductular cells in liver cirrhosis.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Carbon Tetrachloride; Disease Models, Animal; Epithelial- | 2019 |
Native T1 mapping compared to ultrasound elastography for staging and monitoring liver fibrosis: an animal study of repeatability, reproducibility, and accuracy.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Elasticity Imaging Techniques; Humans; Liver; | 2020 |
The Matrine Derivate MASM Inhibits Recruitment of Gr1hi Monocyte and Alleviates Liver Injury.
Topics: Alkaloids; Animals; Anthracenes; Anti-Inflammatory Agents; Antigens, Ly; Carbon Tetrachloride; Chemi | 2019 |
Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Flavano | 2019 |
Repeated versus single transplantation of mesenchymal stem cells in carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Extracellula | 2013 |
Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies.
Topics: Acetophenones; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Cells, Cult | 2013 |
Up-regulation of components of the renin-angiotensin system in liver fibrosis in the rat induced by CCL₄.
Topics: Angiotensin I; Angiotensin II; Animals; Blotting, Western; Carbon Tetrachloride; Gene Expression Reg | 2013 |
Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Collagen; Dependovirus; Disease Models, Animal; E | 2013 |
Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Collage | 2013 |
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.
Topics: Animals; Binding Sites; Carbon Tetrachloride; Cells, Cultured; Cellular Senescence; Cholestasis; Cys | 2013 |
Γ-aminobutyric acid B receptor improves carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Animals; Baclofen; Biomarkers; Blotting, Western; Carbon Tetrachloride; Drug Administration | 2013 |
Modulation of inflammatory response in a cirrhotic rat model with induced bacterial peritonitis.
Topics: Animals; Antibodies, Monoclonal; Carbon Tetrachloride; Ceftriaxone; Escherichia coli; Immunoassay; L | 2013 |
Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Coculture Techniques; Female; Gene Expression Regulation; | 2013 |
Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression.
Topics: Animals; Carbon Tetrachloride; Cell Count; Chemokine CCL5; Cytokines; Disease Models, Animal; Liver; | 2013 |
Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat.
Topics: Acetylcysteine; Allium; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis; Male | 2013 |
BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Down-Regulation; Gene Expression; Heptanoic Acids; | 2013 |
Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hemodynamics; Ligation; Liver Cir | 2013 |
Urine metabolic profile changes of CCl4-liver fibrosis in rats and intervention effects of Yi Guan Jian Decoction using metabonomic approach.
Topics: Animals; Carbon Tetrachloride; Drug Monitoring; Drugs, Chinese Herbal; Gas Chromatography-Mass Spect | 2013 |
Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression.
Topics: Animals; Berberine; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Isoquinolines; Liver Cirrh | 2013 |
Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats.
Topics: Adult; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Carbon Tetrachloride; Dose-Response Rela | 2013 |
Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.
Topics: Animals; Autoantigens; Carbon Tetrachloride; Collagen Type I; Ethanol; Gene Expression Regulation; H | 2013 |
Knockdown of N-acetylglucosaminyl transferase V ameliorates hepatotoxin-induced liver fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Cells, Cultured; Epithelial-Mesenchymal | 2013 |
The chemokine CCL3 promotes experimental liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemokine CCL3; Enzyme-Linked Immunosorbent Assay | 2013 |
CD4+CD25+Foxp3+ regulatory T cells contribute in liver fibrosis improvement with interferon alpha.
Topics: Animals; Carbon Tetrachloride; CD4 Antigens; CD8-Positive T-Lymphocytes; Collagen Type I; Female; Fo | 2013 |
Autologous bone marrow stem cell transplantation attenuates hepatocyte apoptosis in a rat model of ex vivo liver resection and liver autotransplantation.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Disease Mode | 2013 |
Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Molecular MRI of collagen to diagnose and stage liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disease Progression; Gadolin | 2013 |
Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathway.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Caspase | 2013 |
Relaxin decreases the severity of established hepatic fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Hepatic Stellate Cells; Hepatocyte | 2014 |
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Desmin; Disease Models, Animal; Glial Fibril | 2014 |
Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis.
Topics: Adenosine A2 Receptor Antagonists; Alanine Transaminase; Alcoholic Beverages; Animals; Aspartate Ami | 2013 |
Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs.
Topics: Animals; Carbon Tetrachloride; Cordyceps; Down-Regulation; Hepatic Stellate Cells; Liver Cirrhosis; | 2013 |
Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo.
Topics: A Kinase Anchor Proteins; Animals; Carbon Tetrachloride; Cell Cycle Proteins; Cell Movement; Cell Pr | 2013 |
Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Hydroxyproline; Liver; Liver Cirrhosi | 2013 |
Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Dietary Supplements; Forkhead Transcript | 2013 |
Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse.
Topics: Animals; Carbon Tetrachloride; Chromosome Mapping; Chromosomes, Mammalian; Ethanol; Female; Gene Exp | 2013 |
STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Carbon Tetrachloride; Cell Nucleus; Cells, Cultured | 2013 |
The hepatoprotective effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Coumarins; Glutathi | 2013 |
Bevacizumab attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Carbon Tetrachloride; Cell Proliferation; C | 2013 |
Effect of collagen I gel on apoptosis of rat hepatic stellate cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Culture Techniques; Collagen Type I; Cycloheximide; C | 2013 |
Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro.
Topics: Animals; Carbon Tetrachloride; Curcumin; Extracellular Matrix; Extracellular Matrix Proteins; Gene E | 2013 |
Inhibitory effect of gallic acid on CCl4-mediated liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Coll | 2014 |
Therapeutic effects of hepatocyte growth factor-overexpressing human umbilical cord blood-derived mesenchymal stem cells on liver fibrosis in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2014 |
Effects of the dihydrolipoyl histidinate zinc complex against carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antimycin A; Antioxidants; Carbon Tetrachloride; Cells, Cultured; Glutathione; Hepatic Stel | 2014 |
JNK1 and JNK2 regulate α-SMA in hepatic stellate cells during CCl4 -induced fibrosis in the rat liver.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Hepatic Stellate Cells; Immunohistochemist | 2013 |
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferati | 2014 |
Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation.
Topics: Actins; Animals; Apoptosis; beta Catenin; Carbon Tetrachloride; Cell Cycle; Cell Differentiation; Ce | 2014 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; CD11b Antigen; Cell Line, Tumor; Cell Move | 2014 |
P2X7 blockade attenuates mouse liver fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Liver Cirrhosis; Male; Mice; | 2014 |
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.
Topics: Acute Disease; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Ch | 2014 |
Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments.
Topics: Age Factors; Animals; Blotting, Western; Carbon Tetrachloride; CCAAT-Enhancer-Binding Protein-alpha; | 2014 |
Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein.
Topics: Animals; Calcium-Binding Proteins; Carbon Tetrachloride; Electrophoresis, Gel, Two-Dimensional; Glut | 2013 |
The pro-fibrotic effects of pregnancy in a carbon-tetrachloride-induced liver injury in mouse model.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Chemical and Drug I | 2014 |
Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1.
Topics: Animals; Antibodies, Neutralizing; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Hepatic Stel | 2013 |
[Changes of sarcoplasmic reticulum calcium ATPase, titin, and nebulin expressions in the diaphragm of rats with liver cirrhosis].
Topics: Animals; Body Weight; Carbon Tetrachloride; Connectin; Diaphragm; Lipid Peroxidation; Liver; Liver C | 2013 |
Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; | 2014 |
MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.
Topics: Analysis of Variance; Animals; Autoantigens; Basement Membrane; Carbon Tetrachloride; Collagen Type | 2013 |
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Disease Model | 2013 |
The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression.
Topics: Animals; Binding, Competitive; Blood-Brain Barrier; Cannabinoid Receptor Antagonists; Carbon Tetrach | 2014 |
Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.
Topics: Analysis of Variance; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Line; Immunoh | 2014 |
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Tetrachloride; Cell Diffe | 2014 |
Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Line; Collagen Type III; Hepatic Stell | 2014 |
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.
Topics: Animals; Aptamers, Nucleotide; Carbon Tetrachloride; Chemokine CCL2; Disease Models, Animal; Disease | 2014 |
Therapeutic potential of morin against liver fibrosis in rats: modulation of oxidative stress, cytokine production and nuclear factor kappa B.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2014 |
Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Oligonucleotide Arr | 2014 |
Targeted recombinant fusion proteins of IFNγ and mimetic IFNγ with PDGFβR bicyclic peptide inhibits liver fibrogenesis in vivo.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Cells, Cultured; DNA Primers; Escherichia coli; | 2014 |
Wnt-induced secreted protein 1/CCN4 in liver fibrosis both in vitro and in vivo.
Topics: Animals; Base Sequence; Carbon Tetrachloride; CCN Intercellular Signaling Proteins; Cells, Cultured; | 2014 |
Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Flow Cytometry; Hepatic Stellate Cells; Interleukin-6; Liver; | 2014 |
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Topics: Angiotensin II; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; D | 2014 |
Decorin prevents the development of CCl₄-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Decorin; Immunohistochemistry; Liver Cirrhosis; Mice; Transforming Gr | 2014 |
Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl₄ in mice.
Topics: Actins; Amidohydrolases; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Collagen Type I; Dr | 2014 |
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Gene Dele | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Movement; Disease Models, Animal; Fibrosis; F | 2014 |
Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cell Survival; | 2014 |
Viscoelastic parameters for quantifying liver fibrosis: three-dimensional multifrequency MR elastography study on thin liver rat slices.
Topics: Animals; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Liver; Liver Cirrhosis; Ma | 2014 |
Inhibition of ASICs reduces rat hepatic stellate cells activity and liver fibrosis: an in vitro and in vivo study.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Actins; Alanine Transaminase; Amilorid | 2014 |
[Therapeutic effect of BMSCs with over-expressed MMP1 on liver fibrosis].
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Green Fluorescent Proteins; Hematopoietic Stem Cells; L | 2014 |
Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Cell Line; Down-Regulation; Eye Proteins; Female; Gene | 2014 |
Pathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fatty Acids, Unsaturated; Hydroxy A | 2014 |
Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferati | 2014 |
Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Coculture Techniques; Hep | 2014 |
Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Diterpenes; Eleutherococcus; Liver Cirrhosis; Liver | 2014 |
SHSST cyclodextrin complex prevents the fibrosis effect on CCl₄-induced cirrhotic cardiomyopathy in rats through TGF-β pathway inhibition effects.
Topics: Animals; Antioxidants; beta-Cyclodextrins; Carbon Tetrachloride; Cardiomyopathies; Drug Carriers; Dr | 2014 |
Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways.
Topics: Animals; Carbon Tetrachloride; Collagen; Cytokines; Down-Regulation; Gene Knockout Techniques; Hepat | 2014 |
Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-κB, and pro-fibrotic factor TGF-β1 mediating inflammatory signaling.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation | 2016 |
MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Expressi | 2014 |
Apamin inhibits hepatic fibrosis through suppression of transforming growth factor β1-induced hepatocyte epithelial-mesenchymal transition.
Topics: Animals; Apamin; Carbon Tetrachloride; Cell Line; Epithelial-Mesenchymal Transition; Hepatocytes; Li | 2014 |
Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro.
Topics: Actins; Animals; Benzopyrans; Butyrates; Carbon Tetrachloride; Cell Line; Collagen Type I; Disease M | 2014 |
The hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and early liver cirrhosis in a rat model: an experimental study.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Contrast Media; Disease Models, Animal; Gadolin | 2014 |
Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fast Foods; Female; Gene Expression Profiling | 2014 |
Experimental osteoporosis and its correction.
Topics: Albumins; Alkaline Phosphatase; Animals; Bone and Bones; Bone Density; Calcium; Carbon Tetrachloride | 2014 |
Involvement of the nuclear high mobility group B1 peptides released from injured hepatocytes in murine hepatic fibrogenesis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cell Nucleus; Cell Proliferation; Cells, Cultured; | 2014 |
Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis.
Topics: Alcohol Drinking; Animals; Carbon Tetrachloride; Cells, Cultured; Ginsenosides; Hepatic Stellate Cel | 2014 |
Ocimum gratissimum is effective in prevention against liver fibrosis in vivo and in vitro.
Topics: Actins; Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferas | 2014 |
TRPV4 channel inhibits TGF-β1-induced proliferation of hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Hepatic Stellate Cells; Humans; Liver; | 2014 |
Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice.
Topics: Alanine Transaminase; Amniotic Fluid; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Di | 2014 |
Origin of myofibroblasts in the fibrotic liver in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen Type I; | 2014 |
Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Collagen Type I; Connective Tissue Growth Factor; Di | 2014 |
BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor.
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Disease Models, Anim | 2014 |
Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl₄-treated rats.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatic | 2015 |
Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway.
Topics: 3' Untranslated Regions; Actins; Animals; Blotting, Western; Carbon Tetrachloride; Cell Line; Chromo | 2015 |
Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts.
Topics: Abrus; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Carrageenan; Chemical an | 2014 |
Oxymatrine improves intestinal epithelial barrier function involving NF-κB-mediated signaling pathway in CCl4-induced cirrhotic rats.
Topics: Alkaloids; Animals; Carbon Tetrachloride; Endotoxins; Enzyme-Linked Immunosorbent Assay; Gene Expres | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Danshensu-mediated protective effect against hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Cytoprotection; Lactates; Liver; Liver Cirrhosis; Liver | 2014 |
[Gene expression profile changes induced upon umbilical cord mesenchymal cell infusion therapy in a rat model of hepatic cirrhosis].
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Down-Regulation; Gene Expre | 2014 |
Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Connective Tissue Growth Factor; Dis | 2014 |
Oral administration of Saccharomyces boulardii ameliorates carbon tetrachloride-induced liver fibrosis in rats via reducing intestinal permeability and modulating gut microbial composition.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Intestinal Absorption; Intestinal Mucosa; Intes | 2015 |
Prevention of liver fibrosis by intrasplenic injection of high-density cultured bone marrow cells in a rat chronic liver injury model.
Topics: Animals; Blood Vessels; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell C | 2014 |
Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by downregulating CXCR4/7 expression.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Chemokine CXCL12; Corticosterone; Dow | 2015 |
Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corn Oil; | 2014 |
Ginseng extract and ginsenoside Rb1 attenuate carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Ginsenosides; Humans; Intercellular Adhesion Molecule-1; Interleukin- | 2014 |
[Differential proteome analysis of carbon tetrachloride-induced mouse liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Computational Biology; Down-Regulation; Inflammation; Liver Cirrhosis | 2014 |
Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Morphogenetic Protein 7; Cadherins; | 2014 |
IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice.
Topics: Animals; Carbon Tetrachloride; Drug Evaluation, Preclinical; Female; Hepatic Stellate Cells; Interle | 2014 |
[Changes in mitochondria fusion protein-2 hepatic expression in conditions of liver cirrhosis and acute on chronic liver failure].
Topics: Acute-On-Chronic Liver Failure; Animals; Carbon Tetrachloride; GTP Phosphohydrolases; Liver Cirrhosi | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis.
Topics: Actins; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetr | 2014 |
Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1α through an ERK-dependent pathway.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Curcumin; Hypoxia-Inducible Factor 1, alpha Subun | 2014 |
Methanolic extract of Woodfordia fruticosa Kurz flowers ameliorates carbon tetrachloride-induced chronic hepatic fibrosis in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Dose | 2016 |
Protein extracts of Crassostrea gigas alleviate CCl₄-induced hepatic fibrosis in rats by reducing the expression of CTGF, TGF-β1 and NF-κB in liver tissues.
Topics: Animals; Body Weight; Carbon Tetrachloride; Connective Tissue Growth Factor; Crassostrea; Fish Prote | 2015 |
Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cytokines; Disease Progression; Gene Expression; He | 2015 |
Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway.
Topics: Actins; Aldehydes; Animals; Autophagy; Benzopyrans; Carbon Tetrachloride; Cell Line; Dioxoles; Hepat | 2014 |
Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Carbon Tetrachloride; Cell Move | 2015 |
Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis.
Topics: Adipose Tissue; Adult; Animals; Carbon Tetrachloride; Cell Lineage; Female; Humans; Liver Cirrhosis; | 2015 |
Protective effects of Selenium-enriched probiotics on carbon tetrachloride-induced liver fibrosis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Glutathione; Gluta | 2015 |
Mesenteric and splenic contributions to portal venous CT perfusion in hepatic diffuse disease.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dogs; Hepatitis, Animal; Liver Cirrhosis; Mes | 2014 |
PTPRO-associated hepatic stellate cell activation plays a critical role in liver fibrosis.
Topics: Animals; Becaplermin; Carbon Tetrachloride; Cell Proliferation; Hepatic Stellate Cells; Hepatocytes; | 2015 |
Bifidobacterium pseudocatenulatum CECT7765 promotes a TLR2-dependent anti-inflammatory response in intestinal lymphocytes from mice with cirrhosis.
Topics: Animals; Bifidobacterium; Carbon Tetrachloride; Disease Models, Animal; Female; Gastrointestinal Mic | 2016 |
Adipose-derived mesenchymal stem cells inhibit activation of hepatic stellate cells in vitro and ameliorate rat liver fibrosis in vivo.
Topics: Actins; Adipose Tissue; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Cells, Culture | 2015 |
[Dynamics of pro- and macroglycogen content in hepatocytes of normal and cirrhotic rat liver at different stages of glycogenesis].
Topics: Animals; Carbon Tetrachloride; Glucose; Glycogen; Hepatocytes; Liver; Liver Cirrhosis; Male; Rats; R | 2014 |
Hepatocyte-specific ablation of PP2A catalytic subunit α attenuates liver fibrosis progression via TGF-β1/Smad signaling.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Disease Progression; | 2015 |
Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Collagen Type I; Fe | 2015 |
A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-β1 and Suppresses Ongoing Hepatic Fibrosis.
Topics: Actins; Alanine Transaminase; Amino Acid Sequence; Animals; Aspartate Aminotransferases; Bilirubin; | 2015 |
Inhibitory effect of dietary capsaicin on liver fibrosis in mice.
Topics: Animals; Bile Ducts; Capsaicin; Carbon Tetrachloride; Cholestasis; Diet; Disease Models, Animal; Dow | 2015 |
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Topics: Animals; Benzylisoquinolines; Carbon Tetrachloride; Dose-Response Relationship, Drug; Injections, In | 2015 |
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Epoxide Hy | 2015 |
Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Gene Expression Profiling; Liver; Liver Cirrhosis; Mal | 2015 |
Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2015 |
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 2015 |
[Dynamic study on curative effect of Shuganjianpifang against hepatic fibrosis induced by CCl4 in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drugs, Chinese Her | 2014 |
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.
Topics: Adult; Aged; Animals; c-Mer Tyrosine Kinase; Carbon Tetrachloride; Cell Proliferation; Cells, Cultur | 2015 |
Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Dependovirus; Extr | 2015 |
Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Hepatocytes; HMGB1 Protein; Interleukin-1alpha; Interleuki | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Glycyrrhetinic Acid; Liver; Liver Cirrhosis; Male; Rats; Rats, Spragu | 2015 |
Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cholestasis; Disease Models, Animal; Humans; Ligation; Li | 2016 |
Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.
Topics: Alcohol Dehydrogenase; Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; | 2015 |
Hepatitis C Virus Nonstructural 3/4A Protein Dampens Inflammation and Contributes to Slow Fibrosis Progression during Chronic Fibrosis In Vivo.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Carrier Proteins; Cell Proliferation; Chronic Disease; | 2015 |
Endogenous hydrogen sulfide is associated with angiotensin II type 1 receptor in a rat model of carbon tetrachloride-induced hepatic fibrosis.
Topics: Alanine Transaminase; Alkynes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cystathio | 2015 |
Macrophage autophagy protects against liver fibrosis in mice.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cell Lineage; Culture Media, | 2015 |
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Diosgenin; Liver Cirrhosis; Male; Proteomics; Rats; Rats, | 2015 |
Cyanidin-3-O-β-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Glucosides; Hepatic | 2015 |
Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Contrast Media; Gadolinium DTPA; Liver Cirrhosis; Magneti | 2015 |
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Antigens, CD; Antigens, Neoplasm; Becaplermin; Carbon | 2016 |
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; | 2015 |
Hepatic Progenitor Cells Contribute to the Progression of 2-Acetylaminofluorene/Carbon Tetrachloride-Induced Cirrhosis via the Non-Canonical Wnt Pathway.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Differentiation; Female; Inflammation; Li | 2015 |
MiR-22 Suppresses BMP7 in the Development of Cirrhosis.
Topics: 3' Untranslated Regions; Adult; Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Dependo | 2015 |
miR-30c and miR-193 are a part of the TGF-β-dependent regulatory network controlling extracellular matrix genes in liver fibrosis.
Topics: Animals; Area Under Curve; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Down-Regulation; Extra | 2015 |
Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Drugs, Chinese Herbal; Hepatic Stellate Cells; Liver | 2015 |
The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Papillary; Cell Line, Tumor; Cell Prolifer | 2015 |
Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis.
Topics: Adult; Aged; Autophagy; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Humans; | 2015 |
Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; | 2015 |
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Neoplasms; Liver Ne | 2015 |
Hepatocyte Growth Factor Mediates the Antifibrogenic Action of Ocimum bacilicum Essential Oil against CCl4-Induced Liver Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Gene Expression Regulation; Hepatocyt | 2015 |
[Effects of Hemerocallis citrine baroni flavonids on CCl4-induced liver fibrosis of rats].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2015 |
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4‑induced fibrosis in mice.
Topics: Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2015 |
Activation of Slit2-Robo1 signaling promotes liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cell Line; Cells, Cultured; Female; Hepatic Ste | 2015 |
Assessment of liver fibrosis by variable flip angle T1 mapping at 3.0T.
Topics: Acceleration; Animals; Carbon Tetrachloride; Contrast Media; Diffusion Magnetic Resonance Imaging; L | 2016 |
[Spectrum-effect relationship on anti-hepatic fibrosis effect of Radix Hedysari].
Topics: Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fabaceae | 2015 |
Hepatoprotective Effects of Grape Seed Procyanidin B2 in Rats With Carbon Tetrachloride-induced Hepatic Fibrosis.
Topics: Animals; Antioxidants; Biflavonoids; Carbon Tetrachloride; Catechin; Cytokines; Grape Seed Extract; | 2015 |
Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner.
Topics: Adult; Aged; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Mov | 2015 |
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Cytoskeletal Proteins; DNA-Binding Proteins; | 2016 |
Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2015 |
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Carbon Te | 2016 |
Mesenchymal stem cells: In vivo therapeutic application ameliorates carbon tetrachloride induced liver fibrosis in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; ATP Binding Casset | 2015 |
Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.
Topics: Adult; Animals; Carbon Tetrachloride; Collagen; Enzyme Inhibitors; Female; Hepatic Stellate Cells; H | 2017 |
Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Flavonoids; Iris Plant; Liver; Liver Cirrhosi | 2015 |
Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2015 |
Yiguanjian decoction and its ingredients inhibit angiogenesis in carbon tetrachloride-induced cirrhosis mice.
Topics: Actins; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Hyd | 2015 |
Antihepatofibrotic Effects of Aqueous Extract of Prunella vulgaris on Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; Plant Extracts; Protective Agents; Prunella; R | 2016 |
Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T1 relaxation time in the rotating frame.
Topics: Animals; Area Under Curve; Carbon Tetrachloride; Contrast Media; Diffusion Magnetic Resonance Imagin | 2016 |
Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Fun | 2015 |
Production of bioactive recombinant rat soluble receptor for advanced glycation end products (rrsRAGE) in Pichia pastoris.
Topics: Animals; Base Sequence; Bioreactors; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line | 2017 |
Exploring multiple quantitative trait loci models of hepatic fibrosis in a mouse intercross.
Topics: Alleles; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Chimera; Ch | 2016 |
Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Drug Carriers; Human Umbilical Vein Endothelial Cells; Lactic Acid; L | 2016 |
Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regula | 2016 |
Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chronic Disease; Collagen; Extracellular Mat | 2016 |
Doxazosin Treatment Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor β Secretion.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferases; | 2016 |
A model of acute kidney injury in mice with cirrhosis and infection.
Topics: Acute Kidney Injury; Animals; Carbon Tetrachloride; Creatinine; Disease Models, Animal; Echocardiogr | 2016 |
Cultured Mycelium Cordyceps sinensis allevi¬ates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells.
Topics: Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Cordyceps; Drugs, Chinese Herbal; Inflammatio | 2016 |
An experimental study on the assessment of rabbit hepatic fibrosis by using magnetic resonance T1ρ imaging.
Topics: Animals; Carbon Tetrachloride; Image Interpretation, Computer-Assisted; Image Processing, Computer-A | 2016 |
Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocyti | 2015 |
Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis.
Topics: Acetamides; Animals; Autoradiography; Biomarkers; Carbon Tetrachloride; Carrier Proteins; Disease Pr | 2015 |
Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Carbon Tetrachloride; Hepatectomy; | 2015 |
MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis.
Topics: 3' Untranslated Regions; Animals; Benzofurans; Blotting, Western; Carbon Tetrachloride; Cell Line; C | 2016 |
Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Movement; Chemok | 2015 |
Comparative proteomic analysis of fibrotic liver of rats fed high fat diet contained lard versus corn oil.
Topics: Actins; Animals; Carbon Tetrachloride; Corn Oil; Diet, High-Fat; Dietary Fats; DNA Methylation; Endo | 2017 |
Free Radical-Scavenging, Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver Damage.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Cytokines; Free R | 2015 |
Regulatory Effects and Mechanism of Adenovirus-Mediated PTEN Gene on Hepatic Stellate Cells.
Topics: Adenoviridae; Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Cell Cycle; Cell Line; Cell Proli | 2016 |
Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biological Products; Carbon Tetrachloride; Drugs, Ch | 2015 |
Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model.
Topics: Animals; Carbon Tetrachloride; Chitosan; Ethanol; Hepatocytes; Liver Cirrhosis; Plant Extracts; Rats | 2015 |
Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Drug Evaluation, Preclinical; Hepatic Stellate Cells; Hepa | 2016 |
Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Regulation; Liver; Liver Cirr | 2016 |
The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2016 |
Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Su | 2016 |
Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury.
Topics: Acetylation; Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Case-Control Studies; Cell Nuc | 2017 |
Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis.
Topics: Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Disease Models, Animal; Enzyme-Linked Imm | 2016 |
Inhibition of MAPK and NF-κB signaling pathways alleviate carbon tetrachloride (CCl4)-induced liver fibrosis in Toll-like receptor 5 (TLR5) deficiency mice.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; MAP Kinase Signaling System; Mice; Mice, Inbre | 2016 |
Rebamipide retards CCl4-induced hepatic fibrosis in rats: Possible role for PGE2.
Topics: Alanine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbo | 2016 |
Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chronic Disease; Culture Media, Condit | 2016 |
Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrho | 2016 |
Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; C | 2016 |
Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Proliferation; Chemokine CCL2; Chemokine CCL5; Chole | 2016 |
Cannabinoid receptors are involved in the protective effect of a novel curcumin derivative C66 against CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Curcumin; Cytoprotection; Gene Expression Regulation; Hepatic Stellat | 2016 |
[Effects of Ethanol Extracts of Phellinus lonicerinus on Hepatic Stellate Cells of Fibrosis Liver in Rats].
Topics: Actins; Animals; Antioxidants; Basidiomycota; Biological Products; Carbon Tetrachloride; Hepatic Ste | 2015 |
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.
Topics: Aminoquinolines; Animals; Benzimidazoles; Bleomycin; Butylamines; Carbon Tetrachloride; Chemokine CX | 2016 |
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Carcinoma, Hepatocellular; Choline; Chronic Disease; D | 2016 |
The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Cytogl | 2016 |
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ₃ for staging liver fibrosis in rat model.
Topics: Animals; Carbon Tetrachloride; Dextrans; Disease Models, Animal; Hepatic Stellate Cells; Integrin al | 2016 |
Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats.
Topics: Animals; Carbon Tetrachloride; Lipids; Liver; Liver Cirrhosis; Lomustine; Male; Rats, Sprague-Dawley | 2016 |
MicroRNA-125a-5p Contributes to Hepatic Stellate Cell Activation through Targeting FIH1.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Disease | 2016 |
Herbal medicine Gan‑fu‑kang downregulates Wnt/Ca2+ signaling to attenuate liver fibrogenesis in vitro and in vivo.
Topics: Animals; Calcium Signaling; Carbon Tetrachloride; Cell Line; Cell Proliferation; Drugs, Chinese Herb | 2016 |
Protective effects of L-carnosine on CCl4 -induced hepatic injury in rats.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury | 2016 |
Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Communication; Cell Differentiation; Cell Line; Cell Movement; C | 2016 |
Inhibition of SIRT2 suppresses hepatic fibrosis.
Topics: Adult; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Cell Line; Extracellular Signal-Re | 2016 |
Melatonin Pretreatment Enhances the Homing of Bone Marrow-derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis.
Topics: Adipocytes; Adipogenesis; Animals; Antigens, CD34; Bone Marrow Cells; Carbon Tetrachloride; CD11b An | 2016 |
Glutamine inhibits CCl4 induced liver fibrosis in mice and TGF-β1 mediated epithelial-mesenchymal transition in mouse hepatocytes.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Ep | 2016 |
Deferoxamine alleviates liver fibrosis induced by CCl4 in rats.
Topics: Animals; Carbon Tetrachloride; Deferoxamine; Liver Cirrhosis; Male; Oxidative Stress; Random Allocat | 2016 |
Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chalcone; Chemical and Drug Induced Liver Injury; Femal | 2016 |
Trillin Reduces Liver Chronic Inflammation and Fibrosis in Carbon Tetrachloride (CCl4) Induced Liver Injury in Mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrach | 2016 |
Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats.
Topics: Animals; Antiviral Agents; Blotting, Western; Carbon Tetrachloride; Drug Synergism; Drug Therapy, Co | 2016 |
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyc | 2016 |
Metabolic Profile Changes of CCl₄-Liver Fibrosis and Inhibitory Effects of Jiaqi Ganxian Granule.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chromatography, Liquid; Disease Models, Animal; Drugs, Ch | 2016 |
[Dynamic changes of TGF-α and TGF-β1 in rats with liver cirrhosis induced by multiple pathogenic factors].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Endotoxins; Homocysteine; Liver Cirrhosis; Male | 2016 |
Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Culture Media, Conditioned; Dental Pulp; Disease Models, Animal; Fema | 2016 |
Nanoparticle Based Delivery of Quercetin for the Treatment of Carbon Tetrachloride Mediated Liver Cirrhosis in Rats.
Topics: Acrylamides; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotrans | 2016 |
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Communication; Coculture Techniques; Cytokines; Dise | 2016 |
Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cartilage Oligomeric Matrix Protein; Hepat | 2016 |
Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition.
Topics: Animals; Carbon Tetrachloride; Isoflavones; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mitocho | 2016 |
MicroRNA Expression Profiling in CCl₄-Induced Liver Fibrosis of Mus musculus.
Topics: Animals; Carbon Tetrachloride; Gene Regulatory Networks; Liver Cirrhosis; Male; Mice; Mice, Inbred C | 2016 |
MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type | 2016 |
Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; G | 2016 |
Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Female; Histone Deacetylases; Humans; Liver; Liver Cirrhos | 2016 |
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Carrier Proteins; Cholesterol; Disease Models, Ani | 2016 |
Beneficial Effects of Silymarin After the Discontinuation of CCl4-Induced Liver Fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2016 |
Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Ly; Carbon Tetrachloride; Chemokine CCL2 | 2016 |
Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Gene E | 2016 |
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules, Neuronal; Chemical and Drug Induced Liver In | 2016 |
Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Cell Line; Cell Transdifferentiation; Gene Knockdown Te | 2016 |
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Collagen; Collagen Type I; Collagen Type I, | 2016 |
High-fat diet plus carbon tetrachloride-induced liver fibrosis is alleviated by betaine treatment in rats.
Topics: Actins; Animals; Anti-Inflammatory Agents; Antioxidants; Betaine; Carbon Tetrachloride; Collagen Typ | 2016 |
Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
Topics: Actins; Animals; Antigens, CD; Blotting, Western; Cadherins; Carbon Tetrachloride; Cdh1 Proteins; Ce | 2017 |
Gadoxetate-enhanced MR imaging and compartmental modelling to assess hepatocyte bidirectional transport function in rats with advanced liver fibrosis.
Topics: Animals; Bile Ducts, Intrahepatic; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Contrast | 2017 |
Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Cell Line; Fibronectins; Liver; Liver Cirrhosis; Male; Mice; Rats, Wi | 2016 |
Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; ErbB Receptors; Hepatic Stellate Cells; Hepa | 2016 |
Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Colforsin; Hedgehog Proteins; Liver Cirrhosis; Male; Rats; Rats, Spra | 2016 |
Effect of Bioregulators Isolated from Rat Liver and Blood Serum on the State of Murine Liver in Roller Organotypic Culture after CCl4-Induced Fibrosis.
Topics: Animals; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis; Male; Mice; Organ Culture Techniques; | 2016 |
The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Survival; Chemokine CCL2; Hepatic Stellate | 2016 |
Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hepatic Stellate Cells; HMGB1 Protein; Li | 2016 |
Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Line; Cytokines; Hepatic Stellate Cells; Liver; Live | 2016 |
Anti-hepatic fibrosis effects of a novel turtle shell decoction by inhibiting hepatic stellate cell proliferation and blocking TGF-β1/Smad signaling pathway in rats.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Cell Proliferation; Extracellular Matrix; Gene Expr | 2016 |
Protective effects of seed melon extract on CCl
Topics: Actins; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2016 |
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2016 |
The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase 2; DNA Damage; Fruit; Heme Oxygenase-1; Liver; Liver C | 2016 |
Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Crosses, Genetic; Female; G | 2016 |
Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Line; Gene Expression Regulation; Hepatic Stellate Cells; Humans | 2017 |
mTOR Overactivation in Mesenchymal cells Aggravates CCl
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Deletion; Liver; Liver Cirrhosis; Mice; | 2016 |
Dimethyl α-ketoglutarate reduces CCl
Topics: Animals; Autophagy; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hepatic Stellate Cells; | 2016 |
Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a.
Topics: 3' Untranslated Regions; Animals; Base Sequence; beta Catenin; Carbon Tetrachloride; Cell Cycle; Cel | 2016 |
Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
Topics: Alcohol Oxidoreductases; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced | 2017 |
miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Regulation; Hepatocytes; Huma | 2016 |
Erythrocytes Membrane Alterations Reflecting Liver Damage in CCl₄-Induced Cirrhotic Rats: The Ameliorative Effect of Naltrexone.
Topics: Animals; Carbon Tetrachloride; Chemokine CCL4; Erythrocyte Membrane; Erythrocytes; Liver Cirrhosis; | 2016 |
Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction.
Topics: Animals; Artemisinins; Carbon Tetrachloride; Cell Death; Chenodeoxycholic Acid; Gene Expression; Hep | 2017 |
Expression of muscarinic acetylcholine receptors in hepatocytes from rat fibrotic liver.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Female; Hepatocytes; Immunohistochemistry; Liver C | 2017 |
The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Line; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors | 2017 |
Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.
Topics: Animals; Automation, Laboratory; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hydroxypr | 2017 |
Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltran | 2017 |
Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice.
Topics: Animals; Antigens, Surface; Carbon Tetrachloride; Cell Line; Collagen; Extracellular Matrix; Hepatic | 2017 |
Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 CYP2E1; F | 2017 |
The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice.
Topics: Animals; Antifibrinolytic Agents; Becaplermin; Carbon Tetrachloride; Cell Movement; Collagen Type I; | 2017 |
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis.
Topics: Acetylcysteine; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Artemisinins; Autophag | 2016 |
Protective Effects of Hydrolyzed Nucleoproteins from Salmon Milt against Ethanol-Induced Liver Injury in Rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon | 2016 |
Tetramethylpyrazine attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic angiogenesis in rats.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; bcl-2-Associated X Protein; Becaplermin; Carbon Tetrach | 2017 |
Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl
Topics: Animals; Biopsy; Carbon Tetrachloride; Disease Progression; Elasticity Imaging Techniques; Fibrosis; | 2016 |
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Topics: Animals; Benzoquinones; Carbon Tetrachloride; Disease Models, Animal; Hedgehog Proteins; Hepatic Ste | 2017 |
Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice.
Topics: Animals; Autophagy; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2017 |
Optimized Mouse Models for Liver Fibrosis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2017 |
Systematic quantification of histological patterns shows accuracy in reflecting cirrhotic remodeling.
Topics: Algorithms; Animals; Carbon Tetrachloride; Diagnostic Imaging; Disease Models, Animal; Disease Progr | 2017 |
Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Gene Expression Regulation; Hedgehog Proteins; Hu | 2017 |
Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matri | 2017 |
Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Elasticity Imaging T | 2017 |
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Topics: Adenosine; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disea | 2017 |
Positive feedback loop of YB-1 interacting with Smad2 promotes liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Feedback, Physiological; HEK293 Cells; Humans; Liver Cirrh | 2017 |
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H | 2017 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
Human Menstrual Blood-Derived Stem Cells Ameliorate Liver Fibrosis in Mice by Targeting Hepatic Stellate Cells via Paracrine Mediators.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Ce | 2017 |
Antifibrotic action of telmisartan in experimental carbon tetrachloride-induced liver fibrosis in Wistar rats.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Carbon Tetrachloride; Female; Liver Cir | 2016 |
Anti-TGFβ-1 receptor inhibitor mediates the efficacy of the human umbilical cord mesenchymal stem cells against liver fibrosis through TGFβ-1/Smad pathway.
Topics: Animals; Benzamides; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cultured; Combi | 2017 |
Caffeic acid phenethyl ester attenuates liver fibrosis via inhibition of TGF-β1/Smad3 pathway and induction of autophagy pathway.
Topics: Actins; Animals; Autophagosomes; Autophagy; Blotting, Western; Caffeic Acids; Carbon Tetrachloride; | 2017 |
Study on the effects of blueberry treatment on histone acetylation modification of CCl
Topics: Acetylation; Animals; Aspartate Aminotransferases; Blueberry Plants; Carbon Tetrachloride; Disease M | 2017 |
Astragaloside Alleviates Hepatic Fibrosis Function via PAR2 Signaling Pathway in Diabetic Rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cyclic AMP-Depende | 2017 |
Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase 2; Hepatocytes; Liver Cirrhosis; Male; Mice, Inbred BA | 2017 |
Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Disease Models, Animal; Humans; Indoles; Inflammation; Liv | 2017 |
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells | 2008 |
Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen; Liver; Liver Cirrhosis; Male; Malondialdehyde; M | 2008 |
Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats.
Topics: Animals; Biopterins; Carbon Tetrachloride; Cyclic GMP; Enzyme Inhibitors; Hypertension, Portal; Hypo | 2008 |
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Cell Transdifferentiation; Cells | 2008 |
Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
Platelets contribute to the reduction of liver fibrosis in mice.
Topics: Animals; Blood Platelets; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Female; | 2009 |
Methyl palmitate prevents CCl(4)-induced liver fibrosis.
Topics: Animals; Biotransformation; Blotting, Western; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 2008 |
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.
Topics: Amphiregulin; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cells, Cultured; Disease Models, | 2008 |
Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cell Transdifferentiation; Cells, Cultured; Collagen T | 2008 |
Senescence of activated stellate cells limits liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cellular Senescence; Female; Fibroblasts; Humans; Ki | 2008 |
Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Disease Models, Animal; Endoplasmic Reticulum; Hepatocy | 2008 |
Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensi | 2009 |
Lipid peroxidation products do not activate hepatic stellate cells.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Su | 2008 |
Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bidens; Carbon Tetrachloride; Co | 2008 |
The hepatic apelin system: a new therapeutic target for liver disease.
Topics: Adult; Animals; Apelin; Blood Pressure; Carbon Tetrachloride; Carrier Proteins; Case-Control Studies | 2008 |
Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver.
Topics: Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Catalase; Collagen; Glutathione Perox | 2008 |
Localization and expression pattern of cytoglobin in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Cerebral Cortex; Collagen Type I; Collagen Type I, alph | 2008 |
Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Hepatic Stella | 2008 |
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Female; Hepatocytes; Liver; Liver Cirrhosis; Liv | 2009 |
An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbon Tetrachloride; Cardiomyopathies; Cyclic | 2008 |
Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Culture Techniques; Cell Lineage; Cell Transdifferenti | 2009 |
Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis.
Topics: Albumins; Animals; Azo Compounds; Bone Marrow Transplantation; Carbon Tetrachloride; Central Nervous | 2008 |
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Disease Models, Animal; Hepato | 2009 |
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential.
Topics: Actins; Animals; Carbon Tetrachloride; Cathepsin B; Cathepsin D; Cell Line; Cell Proliferation; Cell | 2009 |
Embryonic stem cells reduce liver fibrosis in CCl4-treated mice.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Collagen; Embryonic Stem Cells; Female; Green F | 2008 |
Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis.
Topics: Alanine Transaminase; Aloe; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Complex Mixt | 2009 |
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosylceramides; Hepatic | 2009 |
Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Collagen; Cytoprotection | 2009 |
Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-in
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Extracellular Matr | 2009 |
The preventive effects of heparin-superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Collagenases; Heparin; Liver Cirrhosis; Liver Failure, Acute; Male; M | 2009 |
Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Co | 2009 |
Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Glutathione Peroxidase; Hyaluronic Acid; Hydroxyproline; Laminin; Liv | 2009 |
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Topics: Animals; Carbon Tetrachloride; Disease Progression; Fibrinogens, Abnormal; Gene Deletion; Haptoglobi | 2009 |
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemokine CXCL9; Cohort Studies; Collagen; Disease M | 2009 |
Inflammasome-mediated regulation of hepatic stellate cells.
Topics: Actins; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Carbon Tetrachloride; CARD Signal | 2009 |
Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; CD11b Antigen; CD11c Antigen; Flow Cytometry; Immu | 2009 |
Pirfenidone inhibits carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents by preventing activation of hepatic stellate cells.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Antibody Complex; Carbon Tetrach | 2009 |
Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Live | 2009 |
Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis.
Topics: Angiotensin-Converting Enzyme 2; Animals; Blotting, Western; Carbon Tetrachloride; Liver; Liver Cirr | 2009 |
Overexpression of beta-catenin is responsible for the development of portal hypertension during liver cirrhosis.
Topics: Adenoviridae; Animals; beta Catenin; Carbon Tetrachloride; Disease Models, Animal; Disease Progressi | 2009 |
Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Dietary Supplements; Liver; Liver Cir | 2010 |
Therapeutic efficacy of Traditional Chinese Medicine 319 recipe on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Down-Regulation; Drug Combina | 2009 |
Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Corn Oil; Dietary Fats, Unsaturated; Gene Ex | 2009 |
Use of fractal [corrected] analysis for evaluation of liver structure and function in rats in vivo.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Circulation; Liver Cirrhosis; Male; Rats | 2009 |
Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis.
Topics: Angiotensin II; Animals; Aorta; Blotting, Western; Carbon Tetrachloride; Hypertension, Portal; Liver | 2009 |
Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachloride; Curcumin; Hepatic | 2009 |
Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Base Sequence; Blotting, Western; Carbon Tetrachloride; Cytokines; Electrophoretic Mobility | 2009 |
Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis.
Topics: Actins; Alkaloids; Animals; Anti-Arrhythmia Agents; Carbon Tetrachloride; Collagen; Collagen Type IV | 2009 |
[Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Ethanol; Liver Cirrhosis; Liver Diseases, Alco | 2009 |
Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Liver Cirrhosis; Male; Panax notog | 2009 |
(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.
Topics: Actins; Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransferases; Carbon | 2009 |
Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes.
Topics: Actins; Adoptive Transfer; Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Flow Cytome | 2009 |
The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Male; Plant Extracts; | 2009 |
Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Chlorogenic Acid; Collagen Type I; Collagen Type III; Gene Ex | 2009 |
Oxidative stress modulation by Rosmarinus officinalis in CCl4-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; L | 2010 |
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Transdifferentiation; Disease Models, Anim | 2010 |
[A comparative study of diffusion-weighted magnetic resonance imaging and pathological findings of liver fibrosis in rabbits].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Rabbits; Random Al | 2009 |
QUANTITATIVE STUDY OF COLLAGEN CONTENT IN EXPERIMENTAL CIRRHOSIS.
Topics: Animals; Carbon Tetrachloride; Collagen; Liver Cirrhosis; Liver Cirrhosis, Experimental; Rats | 1947 |
Modification of sleep architecture in an animal model of experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Disease Progression; Dose-Response Relationsh | 2009 |
Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis.
Topics: Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Cell Line, Transformed; Disease Models, Anima | 2010 |
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatocytes; Intercellular S | 2010 |
An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis.
Topics: Adenosine; Animals; Aspartic Acid; Carbon Tetrachloride; Gene Expression Profiling; Gene Expression | 2010 |
The Nonportal Distribution of the Trabeculae in Dietary Cirrhosis of Rats and in Carbon Tetrachloride Cirrhosis of Rats and Guinea-Pigs.
Topics: Animals; Bone and Bones; Carbon Tetrachloride; Diet; Guinea Pigs; Liver; Liver Cirrhosis; Rats | 1947 |
Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cystamine; Disease Models, Animal; Down-Regulation; | 2010 |
Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Down-Regulation; Fraxin | 2010 |
Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation; | 2010 |
Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats.
Topics: Animals; Ascites; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Fatty Liver; Female; Liver | 2010 |
Therapeutic effect of transplanting beta(2)m(-)/Thy1(+) bone marrow-derived hepatocyte stem cells transduced with lentiviral-mediated HGF gene into CCl(4)-injured rats.
Topics: Animals; beta 2-Microglobulin; Bone Marrow; Carbon Tetrachloride; Disease Models, Animal; Female; Ge | 2010 |
Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression.
Topics: Actins; Animals; Bone Marrow Cells; Carbon Tetrachloride; Collagen; Disease Models, Animal; Down-Reg | 2010 |
Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells on nanofibers and their transplantation into a carbon tetrachloride-induced liver fibrosis model.
Topics: Animals; Biomarkers; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; | 2011 |
No contribution of umbilical cord mesenchymal stromal cells to capillarization and venularization of hepatic sinusoids accompanied by hepatic differentiation in carbon tetrachloride-induced mouse liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell- and Tissue-Based Therapy; Fetal Blood; Hu | 2010 |
Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.
Topics: Aged; Aged, 80 and over; Animals; Blood Proteins; Carbon Tetrachloride; Female; Hemoglobins; Hepatit | 2010 |
Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Circadian Rhythm; Gene Expression Regulation; Hepatic Stellate Cells; | 2010 |
The lipotropic factors in the treatment of carbon tetrachloride cirrhosis in rats.
Topics: Animals; Carbon Monoxide; Carbon Monoxide Poisoning; Carbon Tetrachloride; Lipotropic Agents; Liver | 1947 |
Effects of Haobie Yangyin Ruanjian decoction on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Blotting, Western; Carbon Te | 2010 |
Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antioxidants; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2010 |
Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Proliferatio | 2010 |
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Down-Regulation; Drug-R | 2010 |
Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-beta1 pathway.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Down-Regulation; Fibrinolytic Agents; Histocytoche | 2010 |
Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice.
Topics: Actins; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Catechin; Chemical and Drug Induced | 2010 |
Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice.
Topics: Amnion; Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Separation; C | 2010 |
Rat CCl(4)-induced cirrhosis plus total portal vein ligation: a new model for the study of hyperammonaemia and brain oedema.
Topics: Animals; Ascites; Biomarkers; Brain; Brain Edema; Carbon Tetrachloride; Disease Models, Animal; Endo | 2010 |
Treatment with L-valine ameliorates liver fibrosis and restores thrombopoiesis in rats exposed to carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver Cirrhosis; Male; Procoll | 2010 |
Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats.
Topics: Alanine Transaminase; Animals; Blueberry Plants; Carbon Tetrachloride; Drugs, Chinese Herbal; Glutat | 2010 |
Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Topics: Animals; Bile Ducts; Biomarkers; Calcium-Binding Proteins; Carbon Tetrachloride; Cell Lineage; Cell | 2010 |
Enhanced effect of soluble transforming growth factor-beta receptor II and IFN-gamma fusion protein in reversing hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; DNA Primers; Gene Amplification; Interferon-g | 2010 |
Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Hepatic Ste | 2010 |
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Collagen Type I; Disease Models, Animal; | 2010 |
Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression.
Topics: Animals; Carbon Tetrachloride; Cell Line; Collagen Type I; Dose-Response Relationship, Drug; Hepatic | 2011 |
Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3).
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carbon Tetrachloride; Cells, | 2010 |
Effectiveness of the PPARγ agonist, GW570, in liver fibrosis.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Hepatic Stellat | 2010 |
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Re | 2010 |
Bone marrow cells reduce fibrogenesis and enhance regeneration in fibrotic rat liver.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Cells, Cultured; C | 2011 |
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor.
Topics: AC133 Antigen; Amphiregulin; Animals; Antigens, CD; Carbon Tetrachloride; Cell Differentiation; Desm | 2010 |
Protecting effects of vasonatrin peptide against carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Atrial Natriuretic Factor; Carbazoles; Carbon Tetrachloride; Cell Line; Collagen; Cyclic GM | 2010 |
In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity.
Topics: Animals; Antigens; Carbon Tetrachloride; Cell Proliferation; Chemokines; Cytokines; Dendritic Cells; | 2010 |
Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship | 2011 |
Coffee and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Coffee; Cytochrome P-450 CYP1A2; Glutathione; Liver Cirrhosis; Rats | 2011 |
Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; En | 2010 |
Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Bee venom inhibits hepatic fibrosis through suppression of pro-fibrogenic cytokine expression.
Topics: Actins; Alanine Transaminase; Animals; Apitherapy; Aspartate Aminotransferases; Bee Venoms; Carbon T | 2010 |
The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease Models, | 2010 |
Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Extracellular Space; Furosemide; Liver; Liv | 2010 |
Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Dimethylnitrosamine; Fibrosis; Hepatic St | 2010 |
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation.
Topics: Animals; Antibodies, Blocking; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Chemokine CX | 2010 |
Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical and Drug In | 2011 |
The nonportal distribution of the trabeculae in dietary cirrhosis of rats and carbon tetrachloride cirrhosis of rats and guinea-pigs.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diet; Guinea Pigs; Liver; Liver Cirrh | 1946 |
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cyclin-Dependen | 2010 |
Immune modulation of ovalbumin-induced lung injury in mice using β-glucosylceramide and a potential role of the liver.
Topics: Allergens; Animals; Asthma; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Cell Proliferation; Ce | 2011 |
Snail1 transcription factor is a critical mediator of hepatic stellate cell activation following hepatic injury.
Topics: Acute Disease; Adult; Aged; Animals; Blotting, Western; Carbon Tetrachloride; Cell Transdifferentiat | 2011 |
Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Female; Genetic Vectors; Hyaluronic Acid; Immunoblo | 2011 |
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related | 2011 |
Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.
Topics: Actins; Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cell Proliferation; Collagen; G1 Phase | 2011 |
Texture analysis of liver fibrosis microscopic images: a study on the effect of biomarkers.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Fibrillar Collagens; Image Processing, Computer-Assisted; | 2011 |
Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Gene Ex | 2011 |
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
Topics: Acyltransferases; Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; Cells, Cultured; D | 2011 |
Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cholestasis; Collagen Type I; Disease Progression; Liver Cirr | 2011 |
Anti-inflammatory properties of Ajuga bracteosa in vivo and in vitro study and their effects on mouse model of liver fibrosis.
Topics: Ajuga; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Hepatic Stellate Cells; Ligation; Liver; Liver Cirrhosis; | 2011 |
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carrier Proteins; Cell Proliferation; Hepatic Stellate Cells; Liver; | 2012 |
Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Cell Line; Cell Survival; Dictamnus; Drugs, Chi | 2011 |
Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function.
Topics: Animals; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Chemokines; Cytokine TWEAK; Disease M | 2011 |
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
Topics: Acute Disease; Adaptive Immunity; Animals; Antigen Presentation; Carbon Tetrachloride; Cell Differen | 2011 |
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chalcone; Chronic Disease; Collagen Type I; Gene Expression Regulatio | 2011 |
Inflammation does not always kill hepatocytes during liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2011 |
Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Animals; Carbon Tetrachloride; Disease Models, Animal; Ethylene Glycols; Hepa | 2011 |
Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response.
Topics: Aging; Animals; Carbon Tetrachloride; Cell Proliferation; Chronic Disease; Disease Susceptibility; H | 2011 |
Effects and mechanisms of Acremoniumterricola milleretal mycelium on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Acremonium; Animals; Antioxidants; Biological Products; Carbon Tetrachloride; Disease Models, Animal | 2011 |
Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2011 |
Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats.
Topics: Animals; Antigens, CD34; Base Sequence; Carbon Tetrachloride; Cell Differentiation; Cell Survival; C | 2012 |
Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; China; Curcuma; Disease Models, Anima | 2011 |
Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.
Topics: Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Gene Expression Profi | 2011 |
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
Topics: Angiotensin II; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium; Calcium Channel Blockers; | 2012 |
A role for autophagy during hepatic stellate cell activation.
Topics: Actins; Animals; Autophagy; Becaplermin; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; | 2011 |
Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta.
Topics: ADAM Proteins; ADAMTS1 Protein; Aged; Amino Acid Motifs; Animals; Carbon Tetrachloride; Collagen Typ | 2011 |
Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis.
Topics: Adiponectin; Animals; Carbon Tetrachloride; Cells, Cultured; Cytoprotection; Gene Knockout Technique | 2011 |
Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Curcumin; Electrophoretic Mobility Shift Assay | 2011 |
[The effects of prolonged sevoflurane anesthesia on renal function in liver fibrosis rabbits].
Topics: Anesthetics, Inhalation; Animals; Carbon Tetrachloride; Kidney; Kidney Function Tests; Liver Cirrhos | 2011 |
Hepatoprotective effects and mechanisms of dehydrocavidine in rats with carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Antioxidants; Apoptosis; Berberine Alkaloids; Carbon Tetrachloride; Chemical and Drug Induc | 2011 |
Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 2011 |
MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen Type VI; Enzyme-Linked Immunosorbent Assay; Fema | 2011 |
Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cloning, Molecular; Flow Cytometry; Hydroxyprol | 2011 |
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Hepatic Stellate Cells; Humans; Integrin alphaVbeta3 | 2012 |
Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Endothelin-1; GPI-Linked Proteins; Hemochromatosis | 2011 |
Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; | 2012 |
TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Carbon Tetrachloride | 2011 |
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cholesterol, Dietary; Disease Models, Animal; | 2012 |
Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages.
Topics: Acute Lung Injury; Animals; Carbon Tetrachloride; Cell Communication; Cell Movement; Cell Proliferat | 2011 |
Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Pressure; Carbon Tetrachloride; Cy | 2011 |
Augmenter of liver regeneration (ALR) gene therapy attenuates CCl₄-induced liver injury and fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Cytochrome Reductase | 2011 |
Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: modulation of NF-κB, cytokine production and oxidative stress.
Topics: Alanine Transaminase; Allopurinol; Animals; Blotting, Western; Carbon Tetrachloride; Cell Extracts; | 2012 |
Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Line; Humans; In Vitro Techniques; Liver Cirrhosis; | 2011 |
Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Fibrosis; Humans; Interleuki | 2011 |
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.
Topics: Animals; Bacterial Translocation; Bacteroides fragilis; beta-Defensins; Bifidobacterium; Carbon Tetr | 2012 |
Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen; Cytokines; Disease Mod | 2012 |
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cathepsin B; Cathepsin D; | 2012 |
Effects of pentoxifylline on intestinal bacterial overgrowth, bacterial translocation and spontaneous bacterial peritonitis in cirrhotic rats with ascites.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Ascites; Ascitic Fluid; Bacterial Translocatio | 2012 |
Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis.
Topics: Animals; Benzaldehydes; Blotting, Western; Carbon Tetrachloride; Catechols; Cell Proliferation; Cell | 2012 |
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proli | 2012 |
Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Cell Line; Chalcone; Collagen Type I; Epid | 2012 |
Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver.
Topics: Animals; Apoptosis; Binding Sites; Carbon Tetrachloride; Caspase 3; Caspase 7; Cell Proliferation; C | 2012 |
Magnesium chenoursodeoxycholic acid ameliorates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cycloox | 2012 |
18α-Glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Dose-Response Relationship, Dr | 2012 |
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Bromodeoxyuridine; Carbon Tetrachloride; Cell Pr | 2012 |
PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Cyclooxygenase 1; Disease Models, Animal; Endothelium | 2012 |
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Indu | 2012 |
Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats.
Topics: Animals; Ascites; Biomarkers; Carbon Tetrachloride; Endothelial Cells; Endothelium, Lymphatic; Liver | 2013 |
Global analysis of DNA methylation in early-stage liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chromosomes, Mammalian; Computational Biol | 2012 |
C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Caspases; CCAAT-Enhancer-Binding Protein-alpha; Ce | 2012 |
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Connective Tissue Growth | 2012 |
[Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Humans; Liver Cirrhosis; Male; Random Allocat | 2011 |
Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cell Line; Collagen Type I; Gene Knockdown Techniq | 2012 |
Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Acupuncture Therapy; Animals; Carbon Tetrachloride; Combined Modality Therapy; Curcumin; Extracellul | 2012 |
Sulfasalazine prevents the increase in TGF-β, COX-2, nuclear NFκB translocation and fibrosis in CCl4-induced liver cirrhosis in the rat.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrach | 2012 |
Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis.
Topics: Animals; Base Sequence; Carbon Tetrachloride; DNA Primers; Gene Expression Profiling; Immunohistoche | 2012 |
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion; Cell Communication; Cell Proliferation; DNA Repair; Fe | 2012 |
Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line, Tumor; Estradiol; Estrogen | 2012 |
Hepatic miR-29ab1 expression modulates chronic hepatic injury.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Gene Expression Profiling; Gene Expression Regulatio | 2012 |
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Hepa | 2012 |
Polyprenols from Taxus chinensis var. mairei prevent the development of CCl₄-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Glutathione; Glutathione Peroxidase; Hydroxyproline | 2012 |
CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice.
Topics: Actins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; CD11b Antigen | 2012 |
Gadolinium accumulation and fibrosis in the liver after administration of gadoxetate disodium in a rat model of active hepatic fibrosis.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Disease Models, Animal; Gadolinium DTPA; Liver | 2012 |
Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CCL5; Disease Model | 2012 |
[Inhibitory effect of acupuncture on hepatic extracellular matrix production in carbon tetrachloride-induced liver fibrosis rats].
Topics: Acupuncture Therapy; Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Extrace | 2012 |
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.
Topics: Actins; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Antigens, Surf | 2012 |
Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-β1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis.
Topics: Animals; Bone Marrow; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Cells, Culture | 2012 |
Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats.
Topics: Animals; Antiparkinson Agents; Bile Ducts; Blood Pressure; Carbidopa; Carbon Tetrachloride; Disease | 2012 |
Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis.
Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Ascites; Bacterial Translocation; Carbon Tetrachloride | 2012 |
Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Proliferation; Chemokine CCL5; Extracellular Matrix; | 2012 |
Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Disease Progression; Gene Expression Regul | 2012 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, | 2012 |
PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Collagen; Half-Life; Humans; Interleukin-10; Interleukin-1 | 2012 |
Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Curcumin; DNA Primers; HMGB1 Protein; Liver Cirrhosis; | 2012 |
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
Topics: Animals; Apoptosis; Carbon Tetrachloride; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase | 2012 |
Vaccination with platelet-derived growth factor B kinoids inhibits CCl₄-induced hepatic fibrosis in mice.
Topics: Actins; Amino Acid Sequence; Animals; Antibodies, Neutralizing; Autoantibodies; Carbon Tetrachloride | 2012 |
Fibroblast growth factor 7 inhibits cholesterol 7α-hydroxylase gene expression in hepatocytes.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Cell Line, Tumor; Cholesterol 7-alpha-Hydroxyla | 2012 |
Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis.
Topics: Amnion; Animals; Antibody Formation; Carbon Tetrachloride; Cell Transplantation; Disease Models, Ani | 2012 |
Adipose derived mesenchymal stem cells transplantation via portal vein improves microcirculation and ameliorates liver fibrosis induced by CCl4 in rats.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; Mesenchymal Stem Cell Transpla | 2012 |
Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Collagen Type I | 2012 |
Inhibition of hepatic stellate cell activation and liver fibrosis by fat-specific protein 27.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type I; | 2012 |
MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Progression; Inflammation; Liver; Liver Cirrhosis | 2012 |
Acupuncture combined with curcumin disrupts platelet-derived growth factor β receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Acupuncture Therapy; Animals; Carbon Tetrachloride; Combined Modality Therapy; Curcumin; Extracellul | 2012 |
[Effects of acupuncture intervention on hepatic platelet-derived growth factor signaling pathway in CCl4-induced hepatic fibrosis rats].
Topics: Acupuncture Therapy; Animals; Carbon Tetrachloride; Humans; JNK Mitogen-Activated Protein Kinases; L | 2012 |
Mesenteric arteries responsiveness to acute variations of wall shear stress is impaired in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; | 2012 |
Hepatoprotective effects of phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Liver Cirr | 2012 |
Adenoviral dominant-negative soluble PDGFRβ improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats.
Topics: Actins; Adenoviridae; Animals; beta-Galactosidase; Carbon Tetrachloride; Collagen; Disease Models, A | 2012 |
Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1.
Topics: Actins; Alanine Transaminase; Animals; Antigens, CD; Carbon Tetrachloride; Garlic; Liver; Liver Cirr | 2013 |
Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: an animal study.
Topics: Animals; Biopsy, Needle; Carbon Tetrachloride; Contrast Media; Disease Models, Animal; Image Enhance | 2012 |
HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis.
Topics: Animals; Apoptosis; Basigin; Carbon Tetrachloride; Cell Line; Hepatic Stellate Cells; Humans; Liver | 2012 |
Hedgehog controls hepatic stellate cell fate by regulating metabolism.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Cell Transdifferentiation; Cells, Cultured; Gene | 2012 |
Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Apoptosis; Carbon Tetrachloride; Cell Survival; Cells, Cul | 2012 |
Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Connective Tissue | 2013 |
Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Coll | 2012 |
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Curcuma; Curcumin; Disease Progression; Down-Regulation; Humans; Live | 2012 |
Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Liver Cirrhosis; Male; | 2013 |
[Comparison of effect of formulas clearing away heat and promoting blood circulation on prevention and treatment of liver fibrosis in CCl4 mice].
Topics: Animals; Blood Circulation; Body Temperature; Carbon Tetrachloride; Drugs, Chinese Herbal; Hydroxypr | 2012 |
Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice.
Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Carbon Tetrachloride; Chemical and Drug In | 2012 |
[Preventive effect of exogenous hydrogen sulfide on hepatic fibrosis in rats].
Topics: Animals; Carbon Tetrachloride; Extracellular Matrix; Hydrogen Sulfide; Liver; Liver Cirrhosis; Male; | 2012 |
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Extracts; Cell Line; Cell Shape; Collagen | 2013 |
Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Cell Proliferation; Disease Progression; Extracellular | 2012 |
Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Electric Stimulation; Hypertension, Portal; L | 2013 |
Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Gene Expression; Hepatic Stell | 2012 |
Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Collagen; Liver; Liver Cirrhosis; PPAR gamm | 2012 |
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B | 2012 |
Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat.
Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; beta Carote | 2012 |
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Topics: Animals; Antigens, Ly; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; CD11b Antigen; Gene Exp | 2012 |
Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoantibodies; Carbon Tetrachlo | 2013 |
Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Chlorogenic Acid; Cytokines; Enzyme-Linked Immunosorbent Assay; Gene | 2013 |
Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; ErbB Receptors; Female; Liver Cirrhosis; Male | 2013 |
DNA microarray analysis identified molecular pathways mediating the effects of supplementation of branched-chain amino acids on CCl4-induced cirrhosis in rats.
Topics: Amino Acids, Branched-Chain; Animals; Brain; Carbon Tetrachloride; CD36 Antigens; Dietary Supplement | 2013 |
Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats.
Topics: Acetylcholine; Animals; Carbon Tetrachloride; Disease Models, Animal; Endothelium, Vascular; Hypoxia | 2013 |
Bone-marrow-derived cells cultured in serum-free medium reduce liver fibrosis and improve liver function in carbon-tetrachloride-treated cirrhotic mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Cult | 2013 |
In vivo assessment of liver fibrosis using diffuse reflectance and fluorescence spectroscopy: a proof of concept.
Topics: Actins; Animals; Carbon Tetrachloride; Laparoscopy; Liver; Liver Cirrhosis; Liver Function Tests; Ma | 2012 |
Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Dru | 2013 |
Proteomic identification network analysis of haptoglobin as a key regulator associated with liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Computational Biology; Haptoglobins; Liver Cirrhosis; Mice; Protein B | 2013 |
Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis--a serological evaluation.
Topics: Alanine Transaminase; Animals; Biglycan; Biomarkers; Carbon Tetrachloride; Collagen Type I; Creatini | 2013 |
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Cell Transformation, Neoplastic; Diethylnitrosamine | 2013 |
Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Disease Models, Animal; Di | 2013 |
Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Curcumin; Disease Models, An | 2012 |
GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride; | 2013 |
Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Ileum; Immunohis | 2012 |
Magnetic resonance-based total liver volume and magnetic resonance-diffusion weighted imaging for staging liver fibrosis in mini-pigs.
Topics: Animals; Area Under Curve; Carbon Tetrachloride; Contrast Media; Diffusion; Diffusion Magnetic Reson | 2012 |
DNA methylation and MeCP2 regulation of PTCH1 expression during rats hepatic fibrosis.
Topics: Animals; Azacitidine; Carbon Tetrachloride; Cell Line; Cell Transdifferentiation; DNA Methylation; G | 2013 |
Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury.
Topics: Animals; Biliary Tract; Carbon Tetrachloride; Cell Lineage; Cell Transdifferentiation; Cells, Cultur | 2013 |
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice.
Topics: Adiponectin; Animals; Anticholesteremic Agents; Carbon Tetrachloride; Cytokines; Ethanol; Gene Expre | 2013 |
[Effects of genistein on the fenestrae, proliferation and nitric oxide synthesis of liver sinusoidal endothelial cells from carbon tetrachloride-induced experimental hepatic fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Cell Division; Endothelium; Genistein; Growth Inhibitors; Liver; Live | 2002 |
Leptin is essential for the hepatic fibrogenic response to chronic liver injury.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Disease Progression; Fatty Liver; Female; Leptin; Li | 2002 |
Estrogen reduces CCL4- induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon | 2002 |
Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver.
Topics: Albumins; Animals; Biological Transport; Carbon Radioisotopes; Carbon Tetrachloride; Cell Membrane; | 2002 |
[Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Liver; Liver Cirrhosis; Male; Malondialdehyde; Plant | 2002 |
Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension.
Topics: Alanine Transaminase; Alkaline Phosphatase; Angiotensin Receptor Antagonists; Animals; Bile Ducts; B | 2002 |
Pirfenidone effectively reverses experimental liver fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Biliru | 2002 |
Dobutamine prevents experimental postintoxication liver cirrhosis in mice.
Topics: Adrenergic beta-Agonists; Animals; Carbon Tetrachloride; Cell Division; Dobutamine; Dose-Response Re | 2002 |
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cyclic AMP-Dependent Protein Kinases; Cytochrom | 2002 |
Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Blood Pressure; | 2003 |
Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.
Topics: Acute Disease; Adenoviridae; Animals; Antisense Elements (Genetics); Carbon Tetrachloride; Carrier P | 2003 |
DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells.
Topics: Animals; Base Sequence; Binding Sites; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Deoxy | 2003 |
[Effects of ET-1 on isolated perfused rat liver and vascular rings at two stages of cirrhosis].
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Endothelin-1; Hypertension, Portal; | 2002 |
Effects of 1,25(OH)2D3 on turnover, mineralization, and strength of bone in growing rats with liver cirrhosis induced by administration of carbon tetrachloride.
Topics: Animals; Biomechanical Phenomena; Bone Development; Calcification, Physiologic; Calcitriol; Calcium | 2003 |
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.
Topics: Acute Disease; Adolescent; Adult; Aged; Animals; Antigens, CD; Carbon Tetrachloride; Cell Division; | 2003 |
Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Drugs, Chinese Herbal; Gene Expression; Liver; Liver Cirr | 2003 |
Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Dinoprostone; Endothelin-1; Gene Expression; Kupffer | 2003 |
Hepatic and mesenteric nitric oxide synthase expression in a rat model of CCl(4)-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Endotoxins; Liver; Liver Circulation; Liver Cirrhosis; Male; Mesenter | 2003 |
Studies in fibrosis of the liver induced by carbon tetrachloride. III. Pantothenic acid and liver fibrosis.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver Cirrhosis; Pantothenic Acid | 1954 |
[Carbon tetrachloride cirrhosis and restoration of the liver].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver Cirrhosis; Liver Cirrhos | 1953 |
[Effect of adenylpyrophosphate on liver cirrhosis due to CCl4 and on regenerative capacity of liver in this disease].
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver | 1954 |
Effect of cortisone on carbon tetrachloride cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Cortisone; Fibrosis; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1954 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Electrophoretic data on blood proteins in CCl4-induced cirrhosis in albino rats].
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Humans; Liver Cirrhos | 1957 |
[Effects of thioctic acid and partial hepatectomy in experimental hepatic fibrosis induced by carbon tetrachloride].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver; Liver Cirrhosis; Thioctic | 1957 |
[Histochemical localization and chemical determination of the alkaline phosphatase activity of the liver in cirrhosis caused by carbon tetrachloride in white rats].
Topics: Alkaline Phosphatase; Animals; Biological Phenomena; Carbon Tetrachloride; Liver Cirrhosis; Liver Ci | 1957 |
[Histochemical picture and acid phosphatase activity of the liver in cirrhosis caused by carbon tetrachloride in white rats].
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; Pho | 1957 |
[Histometric research on the effect of ACTH on hepatic fibrosis caused by carbon tetrachloride].
Topics: Adrenocorticotropic Hormone; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; | 1957 |
The effect of dietary cirrhosis and CC1- poisoning on glucuronyl transferase activity of rat liver.
Topics: Animals; Carbon Tetrachloride; Diet; Liver Cirrhosis; Liver Diseases; Nutrition Disorders; Rats; Tra | 1961 |
Liver regeneration after partial hepatectomy in carbon tetrachloride-induced cirrhosis in the rat.
Topics: Animals; Carbon Tetrachloride; Digestion; Hepatectomy; Liver; Liver Cirrhosis; Liver Cirrhosis, Expe | 1961 |
[Methods of induction in rabbits of cirrhosis of the liver with splenomegaly and ascites by means of carbon tetrachloride].
Topics: Animals; Ascites; Carbon Tetrachloride; Lagomorpha; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1960 |
[Inhibitory action of prednisone on the development of hepatic sclerosis induced by carbon tetrachloride].
Topics: Carbon Tetrachloride; Liver Cirrhosis; Prednisone; Sclerosis | 1959 |
[Cell respiration of hepatic tissue in experimental cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Cell Respiration; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1959 |
[Changes in the activity of individual enzymes in the liver in cirrhosis produced by carbon tetrachloride in rats].
Topics: Animals; Carbon Tetrachloride; Enzymes; Fibrosis; Liver Cirrhosis; Liver Diseases; Rats | 1961 |
[Histochemical changes in carbon tetrachloride-induced cirrhosis of rats after partial hepatectomy].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver Cirrhosis; Liver C | 1962 |
[Morphological and functional phases of development of experimental liver cirrhosis under the influence of carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1962 |
Cell proliferation and fiber formation in chronic carbon tetrachloride intoxication. A morphologic and chemical study.
Topics: Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Hepatitis; Liver Cirrho | 1963 |
[Studies on therapeutic alteration of experimental liver cirrhosis in rats. III. Carbon tetrachloride cirrhosis in rats and its therapeutic alteration by gluco corticoids with and without simultaneous administration of antibiotics and androgens].
Topics: Adrenal Cortex Hormones; Androgens; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Car | 1963 |
[RESEARCH ON THE PROBLEM OF MODIFICATION OF EXPERIMENTAL LIVER DAMAGE BY CARBON TETRACHLORIDE IN CHICKENS].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1963 |
[THE EFFECT OF MAGNESIUM AND VITAMIN E ON THE ACUTE CARBON TETRACHLORIDE DAMAGE OF THE RAT LIVER].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1963 |
[COLLAGENASE ACTIVITY OF CERTAIN HEPATIC EXTRACTS. ITS CHANGES IN THE CARBON TETRACHLORIDE-POISONED RAT].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1964 |
[STUDIES ON EXPERIMENTAL HEPATIC PATHOLOGY. I. MORPHOPATHOLOGY OF ACUTE POISONING DUE TO CARBON TETRACHLORIDE IN THE SYRIAN GOLDEN HAMSTER].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cricetinae; Kidney; Liver Cirrhosis; | 1964 |
[EFFECT OF PARTIAL HEPATECTOMY ON THE RESTITUTION OF THE ANGIOARCHITECTONICS IN THE LIVER OF RATS WITH CARBON TETRACHLORIDE CIRRHOSIS].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepate | 1964 |
EFFECT OF IRON LOADING UPON THE FORMATION OF COLLAGEN IN THE HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE.
Topics: Alanine Transaminase; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; | 1964 |
[A STUDY OF THE FREE AMINO ACIDS IN THE SERUM OF LIVER DISEASES].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Blood; Carbon Tetrachloride; Chemical and Drug Ind | 1964 |
RENAL GLOMERULAR LESIONS AFTER ADMINISTRATION OF CARBON TETRACHLORIDE AND ETHIONINE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Electrons; Ethionine; Kidney Glomerulus; Liver | 1964 |
EFFECT OF DIETARY PROTEIN ON CARBON TETRACHLORIDE-INDUCED HEPATIC FIBROGENESIS IN ALBINO RATS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietar | 1965 |
PORTAL VENOUS PRESSURE IN ACUTE HEPATIC NECROSIS AND EARLY CIRRHOSIS DUE TO CARBON TETRACHLORIDE.
Topics: Blood Pressure; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; Liver Cirrhos | 1965 |
[CANCER OF LIVER ON CIRRHOSIS DUE TO CARBON TETRACHLORIDE].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; Liver Neoplasms; Toxicology | 1964 |
CHANGES OF MAST CELL POPULATION IN RAT LIVER DURING DEVELOPMENT OF CARBON TETRACHLORIDE-INDUCED CIRRHOSIS.
Topics: Carbon Tetrachloride; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental; Mast Cells; Pathology; | 1965 |
CARDIAC HYPERTROPHY IN RATS WITH CARBON TETRACHLORIDE CIRRHOSIS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cardiomegaly; Chemical and Drug Induced Liver | 1965 |
[MINICIONE G, PAGNINI P, GORI F: (DEVELOPMENT OF EXPERIMENTAL CIRRHOSIS FROM CARBON TETRACHLORIDE IN THE "REGENERATED" LIVER OF RATS SUBJECTED TO WIDE HEPATECTOMY)].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver Cirrhosis; Liver C | 1964 |
INFLUENCE OF CARBON TETRACHLORIDE-INDUCED CIRRHOSIS ON THE INCIDENCE OF RESTRAINT-STRESS EROSIONS IN THE STOMACH OF RATS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Fatty Liver; Gastric Mucosa; Incidence; Inject | 1965 |
TOLERANCE TO CARBON TETRACHLORIDE IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug T | 1965 |
FIBROGENESIS ALONG THE HEPATIC SINUSOIDS IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS. AN ELECTRON MICROSCOPIC STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1965 |
[Effect of partial hepatectomy on experimental hepatic fibrosis produced by carbon tetrachloride experimental study].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver; Liver Cirrhosis | 1954 |
Carbon tetrachloride cirrhosis in rats. 1. The influence of age, sex, and gonadectomy; 2. The changes in the livers of the fetuses born to mothers exposed to carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Female; Fetus; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1962 |
Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.
Topics: Actins; Animals; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2003 |
High expression of the CD14 gene and interleukin-1beta gene in the liver and lungs of cirrhotic rats after partial hepatectomy.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Gene Expression; Hepatectomy; Interleuki | 2003 |
The influence of continuous seven-day elevated intra-abdominal pressure in the renal perfusion in cirrhotic rats.
Topics: Abdomen; Aldosterone; Animals; Blood Pressure; Carbon Tetrachloride; Catheterization; Femoral Artery | 2003 |
Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Caspases; Dose-Response Relationship, Drug; Enz | 2003 |
Salviae miltiorrhizae ameliorates cirrhosis and portal hypertension by inhibiting nitric oxide in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Hypertension, Portal; Liver; Liver Circulation | 2003 |
Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma 256, Walker; Disease Models, Animal; Killer Cells, Natural; | 2003 |
Alteration of intestinal intraepithelial lymphocytes and increased bacterial translocation in a murine model of cirrhosis.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; CD3 Complex; Ethanol; Interleukin-12; Interl | 2003 |
Reverse transformation of hepatic myofibroblast-like cells by TGFbeta1/LAP.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Extracellular Matrix; Fibroblasts; L | 2003 |
Effect of IGF-I on total serum antioxidant status in cirrhotic rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Insulin-Like Growth Factor I; Liver Cirrhosis; Male; Ra | 2003 |
4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells.
Topics: Actins; Acute Disease; Aldehydes; Animals; Apoptosis; Carbon Tetrachloride; Cell Death; Cells, Cultu | 2004 |
Effects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Interleukin | 2004 |
Effects of estradiol on liver estrogen receptor-alpha and its mRNA expression in hepatic fibrosis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Estradiol; Estroge | 2004 |
Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Gene Expression Regulation; Immunohistochemistry; | 2004 |
[Hypophysectomy does not modify the course of carbon tetrachloride hepatic cirrhosis].
Topics: Carbon Tetrachloride; Hypophysectomy; Liver; Liver Cirrhosis | 1950 |
[Regeneration of the liver and rapid reversion of carbon tetrachloride cirrhosis after excision of a large part of the cirrhotic liver].
Topics: Carbon Tetrachloride; Liver Cirrhosis; Regeneration | 1951 |
Histochemical and microchemical changes in experimental cirrhosis and hepatoma formation in mice by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Cirrhosis, Experime | 1951 |
[Hepatic cirrhosis and occupational diseases].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; Occupational Diseases | 1952 |
Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Ginkgo biloba; Liver Cirrhosis; Male; Phytotherapy; Plant Extracts; R | 2004 |
Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Fibrosis; Gene Expression Regulation; | 2004 |
[Experimental study on iNOS gene transfer mediated by liposome to treat portal hypertension in cirrhotic rats].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Immunohistochemistry; L | 2004 |
Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Cross-Linking Reagents; Dipeptide | 2004 |
Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.
Topics: Amino Acids; Animals; Atrophy; Biological Transport; Carbon Tetrachloride; Galactose; Insulin-Like G | 2004 |
Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Hepatocytes; Liver; Liver Cirrhosis; | 2004 |
The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl4 administration.
Topics: Animals; Brain Chemistry; Carbon Tetrachloride; Liver; Liver Cirrhosis; Male; Muscle, Skeletal; Oxid | 2004 |
Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Heat-Shock | 2004 |
Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihype | 2004 |
Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Differentiation; Female; Liver Cirrhosis; Male; Mesoderm | 2004 |
The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Carb | 2004 |
Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Female; Gene Expression; Hepatocyte Growth Factor; Humans; In Situ Hy | 2004 |
Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1.
Topics: Animals; Atrophy; Carbon Tetrachloride; Estrogens; Follicle Stimulating Hormone; Hypogonadism; Insul | 2004 |
Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytotoxins; Dr | 2004 |
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.
Topics: Actins; Animals; Antibodies; Carbon Tetrachloride; Collagen; Liver Cirrhosis; Male; Matrix Metallopr | 2004 |
Gene positional changes relative to the nuclear substructure during carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Albumins; alpha-Fetoproteins; Animals; Biomarkers; Calcium Channels; Carbon Tetrachloride; Cell Nucl | 2004 |
Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibroblast Growth Factor 7; | 2004 |
Arg-Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen production and acceleration of collagenase activity.
Topics: Animals; Carbon Tetrachloride; Cell Line; Collagen; Collagenases; Gene Expression Regulation; Humans | 2004 |
Effects and regulation of osteopontin in rat hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Collagen Type I; Humans; Kupffer C | 2004 |
Optical biopsy of liver fibrosis by use of multiphoton microscopy.
Topics: Animals; Biopsy; Carbon Tetrachloride; Hepatocytes; Image Enhancement; Liver; Liver Cirrhosis; Male; | 2004 |
Metallothionein gene therapy for chemical-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Enzyme Activation; Fibrinolysis; Genetic Therapy; Liver Cirrhosis; Me | 2004 |
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2004 |
Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats.
Topics: Alanine Transaminase; Angiotensin II Type 1 Receptor Blockers; Animals; Aspartate Aminotransferases; | 2004 |
Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Disease Models, Animal; Glucose; Glucose Transp | 2005 |
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
Topics: Animals; Carbon Tetrachloride; Hepatocytes; Liver Cirrhosis; Male; Mice; Mice, Knockout; Pregnane X | 2005 |
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.
Topics: Animals; Carbon Tetrachloride; CD11b Antigen; Cytokines; Diphtheria Toxin; Extracellular Matrix; Fem | 2005 |
Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Progression; Dose-Response Relationship, Dru | 2004 |
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase | 2005 |
Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2005 |
Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Gene Deletion; Intercellular Adhesion Molecule-1; Interleukin-6; Live | 2005 |
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enz | 2005 |
Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10.
Topics: Animals; Carbon Tetrachloride; Immunohistochemistry; Interleukin-10; Liver; Liver Cirrhosis; Male; M | 2005 |
Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Flavones; Hep | 2005 |
Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2005 |
Efficacy of Chinese medicine Yi-gan-kang granule in prophylaxis and treatment of liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Drugs, Chinese Herbal; Hepatocytes; Lipid Peroxidati | 2005 |
Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Dimethylnitrosamine; Hematop | 2005 |
Reversibility of experimental rabbit liver cirrhosis by portal collagenase administration.
Topics: Animals; Carbon Tetrachloride; Collagen; Collagenases; Infusions, Intravenous; Liver; Liver Cirrhosi | 2005 |
Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2005 |
Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis; Male; Orchidaceae; Phyt | 2005 |
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Collagen; Collagen Type I; DNA-Binding Proteins; Enhanc | 2005 |
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fem | 2005 |
Modeling liver fibrosis in rodents.
Topics: Actins; Animals; Animals, Genetically Modified; Apoptosis; Azo Compounds; Carbon Tetrachloride; Colo | 2005 |
Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 2005 |
Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Division; Hep | 2005 |
[Experimental research on non-invasive near-infrared detection of early hepatocirrhosis].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Early Diagnosis; Liver; Liver Cirrhos | 2005 |
Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Gene Expressio | 2006 |
Differential gene expression profiles in the steatosis/fibrosis model of rat liver by chronic administration of carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2005 |
The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Cell Proliferation; Desmin; Gold Compounds; Hep | 2006 |
Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Body We | 2006 |
Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cyclohexanecarboxylic Acids; Diuresis; Enzyme Inhi | 2006 |
Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats.
Topics: Albumins; alpha-Fetoproteins; Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation | 2006 |
Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice.
Topics: Actins; alpha-MSH; Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cyclooxygenase 2; Electro | 2006 |
Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis.
Topics: Animals; Base Sequence; Blood Pressure; Carbon Tetrachloride; Diterpenes; Ginkgolides; Hypertension, | 2006 |
Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation.
Topics: alpha 1-Antitrypsin; Animals; Apolipoprotein A-I; Apolipoproteins C; Bone Marrow Transplantation; Ca | 2006 |
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibroblasts; Galectin 3; Humans; Inflammation; Liver; Liver Cirrhosis | 2006 |
Therapeutic effect of interleukin-10 on CCl4-induced hepatic fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Immunohistochemistry; Interleukin | 2006 |
Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: changes in glycosylation and luminal bacteria.
Topics: Animals; Antioxidants; Bacteria; Bacterial Adhesion; Carbohydrate Metabolism; Carbon Tetrachloride; | 2006 |
Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats.
Topics: Animals; Carbon Tetrachloride; Fibroblasts; Gene Expression Regulation; Hepatocytes; In Situ Hybridi | 2006 |
Effect of WeiJia on carbon tetrachloride induced chronic liver injury.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen T | 2006 |
Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Fas Ligand Protein; fas Receptor; Interleukin-10; | 2006 |
Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Connective Tissue Growth Factor; Gene Expression; Gene | 2006 |
Relationship between transforming growth factor beta1 and anti-fibrotic effect of interleukin-10.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Gene Expression; Immunohistochemistry; Interleukin-10; | 2006 |
Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Collagen Type I; Fermentation; Hydroxyproline; Liver C | 2006 |
Cryopreserved fetal liver cell transplants support the chronic failing liver in rats with CCl4-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Cryopreservation; Cytochrome P-450 Enzyme System; Di | 2006 |
Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Disease Progression; Enzyme-Linked Immunosorb | 2006 |
Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury.
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Etanercept; Immunoglobulin G; Inte | 2006 |
Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hydroxyproline; Inflammation; Liver Cirrh | 2006 |
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; DNA; Down-Regula | 2006 |
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachlorid | 2006 |
Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen T | 2006 |
Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Cytochrome P-450 CYP2E1; Hepatocyt | 2006 |
Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Cross-Linking R | 2006 |
Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices.
Topics: Actins; Aged; Animals; Carbon Tetrachloride; Extracellular Matrix; Female; Humans; Liver Cirrhosis; | 2007 |
The effects of interleukin-10 on the expression of Fas and FasL in rat hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Fas Ligand Protein; fas Receptor; Gene Expression Regulation; Interle | 2006 |
Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2006 |
Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Differentiation; Disease Models, | 2006 |
Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis.
Topics: Anastomosis, Surgical; Anesthetics, Intravenous; Animals; Carbon Tetrachloride; Disease Models, Anim | 2006 |
Impaired extracellular matrix degradation in aortic vessels of cirrhotic rats.
Topics: Animals; Aorta; Apoptosis; Carbon Tetrachloride; Collagen Type IV; Extracellular Matrix; Liver; Live | 2007 |
JinSanE decoction, a chinese herbal medicine, inhibits expression of TGF-beta1/Smads in experimental hepatic fibrosis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drugs, Chinese Her | 2006 |
Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; | 2007 |
Protective effect of verapamil on multiple hepatotoxic factors-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Dietary Fats; Disease Models, | 2007 |
Actinidia rubricaulis attenuates hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Actinidia; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Drugs, Chinese | 2007 |
[Cystic degeneration in liver injury induced by CCl4 in SD rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cysts; Disease Models, Animal | 2006 |
Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats.
Topics: Animals; Anticholesteremic Agents; Carbon Tetrachloride; Cyclic GMP; Liver; Liver Cirrhosis; Liver D | 2007 |
Embryonic stem cells develop into hepatocytes after intrasplenic transplantation in CCl4-treated mice.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cell Transplantation; | 2007 |
Hepatic stellate cells: the only cells involved in liver fibrogenesis? A dogma challenged.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Re | 2007 |
Increased Smad1 expression and transcriptional activity enhances trans-differentiation of hepatic stellate cells.
Topics: Actins; Adenoviridae; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Cell Prolifera | 2007 |
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
Topics: Amidohydrolases; Animals; Blood Pressure; Cannabinoid Receptor Modulators; Carbon Tetrachloride; Dis | 2007 |
Rating of CCl(4)-induced rat liver fibrosis by blood serum glycomics.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Male; Polysaccharides; Rats; Rats, Wistar | 2007 |
Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Fe | 2007 |
Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Division; Cells, Cultured; Disease Models, An | 2007 |
Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrach | 2007 |
Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cystamine; Disease Progression; Enzyme Inhibitors; | 2007 |
Male gonadal function, prolactin secretion and lactotroph population in an experimental model of cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Count; Estradiol; Follicle Stimulating Hormone; Gonadotropins, P | 2007 |
Reversal of hepatotoxin-induced pre-fibrogenic events by Emblica officinalis--a histological study.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Drug Evaluation, Preclinical; Liver; Liver Cirrhosis; Ph | 2007 |
Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Genistein; Immunohistochemis | 2008 |
Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis.
Topics: Acetophenones; Adult; Aged; Animals; Antioxidants; Blood Pressure; Carbon Tetrachloride; Dose-Respon | 2007 |
Cytotoxic effects of the conjugated linoleic acid isomers t10c12, c9t11-CLA and mixed form on rat hepatic stellate cells and CCl4-induced hepatic fibrosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen; Diet; DNA Fragmentation; Extracellular Signal-Re | 2008 |
Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Disease Models, Animal; Enzyme Induction; Heme | 2007 |
Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.
Topics: Animals; Automation; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Fibrosis; Hydr | 2007 |
Inhibition of the renin-angiotensin system attenuates the development of liver fibrosis and oxidative stress in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxid | 2008 |
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.
Topics: ADAM Proteins; ADAMTS Proteins; ADAMTS4 Protein; Animals; Carbon Tetrachloride; Collagen; Gene Expre | 2007 |
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis.
Topics: Animals; Carbon Tetrachloride; Elasticity; Extracellular Matrix; Liver; Liver Cirrhosis; Male; Mecha | 2007 |
Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB.
Topics: Animals; Carbon Tetrachloride; Coculture Techniques; Gene Expression Regulation; Hepatocytes; Liver; | 2007 |
Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Liver; Liver Cirrhosis; Mal | 2008 |
Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Hypoxia; Chemokine CCL2; Chemotaxis, Leukocyte; Collagen Type I; | 2008 |
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; | 2008 |
Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury.
Topics: Actins; Alanine Transaminase; Animals; Bilirubin; Blotting, Western; Carbon Tetrachloride; Gene Expr | 2008 |
Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Body Weight; Carbon Tetrachloride; Disease | 2008 |
Fucoidan partly prevents CCl4-induced liver fibrosis.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cel | 2008 |
Prevention of CCl4-induced liver cirrhosis by ribbon antisense to transforming growth factor-beta1.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Collagen; DNA; Gene Expression Regulation; Liver; Live | 2008 |
Experimental cirrhosis due to carbon tetrachloride and the influence of diet on the evolution of lesions; Importance of vascular injury.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis | 1949 |
Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chin | 2007 |
Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Endothelin-1; Kupffer Cells; Liver Cirrhosis; | 2008 |
[Effect of Baoganning on serum and hepatic leptin and its receptor levels in rats with liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Leptin; Liver; Liver Cirrhosis; Male; Phytothe | 2008 |
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Spa | 2008 |
Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibrosis; Genes, | 2008 |
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Endoplasmic Reticulum; Hepatocytes; Liver Cirrhosis; Male; Microscopy | 2008 |
Cardiotrophin-1 enhances regeneration of cirrhotic liver remnant after hepatectomy through promotion of angiogenesis and cell proliferation.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cytokines; Hepatectomy; Hepatocytes; Liver Cirrho | 2008 |
Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis.
Topics: Acute Disease; Animals; Bidens; Carbon Tetrachloride; Drugs, Chinese Herbal; Gene Expression Regulat | 2008 |
Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatocyt | 2008 |
Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice.
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver Cirrhosi | 2008 |
Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.
Topics: Actins; Animals; Antibodies, Monoclonal; Antibody Specificity; Apoptosis; Carbon Tetrachloride; Epit | 2008 |
Critical role of CD44 in hepatotoxin-mediated liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; H | 2008 |
Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis.
Topics: Alkaloids; Animals; Antiviral Agents; Carbon Tetrachloride; CREB-Binding Protein; Liver Cirrhosis; M | 2008 |
Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
[Effects of Danggui Buxue Decoction on liver fibrosis and hepatic lipid peroxidation in rats].
Topics: Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Lipid Peroxidation; Liver; Liver Cir | 2008 |
Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Corn Oil; Dinoprost; Hydroxyproline; Lip | 2008 |
Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Aspartate A | 2008 |
Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis.
Topics: Alanine Transaminase; Animals; Arginine; Blotting, Western; Carbon Tetrachloride; Chronic Disease; D | 2008 |
Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dopamine beta-Hydroxylase; Down-Regulation; G | 2008 |
Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Acetylcholine; Acetylcholinesterase; Actins; Animals; Atropine; Bone Morphogenetic Protein 6; Bone M | 2008 |
Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice.
Topics: Alanine Transaminase; Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Collagen; Cyclooxygenas | 2008 |
Evaluation of phenyl acetate esterase activity as an index of liver damage.
Topics: Animals; Carbon Tetrachloride; Cholinesterases; Clinical Enzyme Tests; Electrophoresis; Esterases; E | 1967 |
Lysyl oxidase and collagenase in experimental acute and chronic liver injury.
Topics: Amino Acid Oxidoreductases; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Female; Live | 1982 |
Different effects of carbon tetrachloride toxicity and cirrhosis on substrate binding to rat hepatic microsomal cytochrome P-450.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Ethylmorphine; Liver Cirrhosis; Male; | 1984 |
Lymphatic role in the pathogenesis of fat malabsorption in liver cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Intestine, Small; Linoleic Acid; Linoleic Acids; Lipids; Liver Cirrho | 1982 |
Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat.
Topics: Animals; Carbon Tetrachloride; Chenodeoxycholic Acid; Cholestyramine Resin; Liver; Liver Cirrhosis; | 1980 |
Renal effects of nitric oxide synthesis inhibition in cirrhotic rats.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Animals; Arginine; Carbon Tetrachloride; Diuresis; Glomer | 1994 |
Inhibition of liver fibrosis by ellagic acid.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Carbon Tetrachloride; Ellagic Aci | 1996 |
Heterogeneity of liver cells expressing procollagen types I and IV in vivo.
Topics: Adult; Animals; Carbon Tetrachloride; Desmin; Endothelium; Epithelial Cells; Epithelium; Extracellul | 1997 |
Effect of narcotic agents and of bleeding on systemic and renal haemodynamics in healthy and CCl4-treated cirrhotic rats.
Topics: Animals; Blood Pressure; Butyrophenones; Carbon Tetrachloride; Diazepam; Disease Models, Animal; Dru | 1997 |
Chronic administration of octreotide ameliorates portal hypertension and portal hypertensive gastropathy in rats with cirrhosis.
Topics: Animals; Carbon Tetrachloride; Gastric Mucosa; Gastrointestinal Agents; Hypertension, Portal; Liver | 1998 |
Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis.
Topics: Animals; Base Sequence; Blotting, Northern; Carbon Tetrachloride; Dose-Response Relationship, Drug; | 1999 |
Expression of connective tissue growth factor in experimental rat and human liver fibrosis.
Topics: Adolescent; Adult; Animals; Bile Ducts; Carbon Tetrachloride; Cell Line, Transformed; Connective Tis | 1999 |
Progression of hepatic stellate cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesis.
Topics: Actins; Animals; Arginase; Biological Assay; Carbon Tetrachloride; Cells, Cultured; Cytokines; Disea | 2000 |
Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirrhosis.
Topics: Acute Disease; Animals; Blotting, Northern; Bone Marrow; Carbon Tetrachloride; Cells, Cultured; Cyto | 2000 |
The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Artemisia; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Hot Temperature; Hydroxyp | 2000 |
Time-course of changes in hepatic lipid peroxidation and glutathione metabolism in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Inactiv | 2000 |
Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis.
Topics: Animals; Arachidonate 5-Lipoxygenase; Blood Pressure; Calcium; Carbon Tetrachloride; Cell Size; Cell | 2000 |
Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats.
Topics: Actins; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Cycl | 2000 |
Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Colchicine; Disease Models, Animal; Dose-Response Relat | 2000 |
Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Humans; Immunohistochemistry; Liver; Liver Cirrhosi | 2000 |
Influence of intestinal flora on the development of fibrosis and cirrhosis in a rat model.
Topics: Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Ethanol; Intestines; Liver Cirrhosis; Male; Mo | 2000 |
CYP11B2 expression in rat liver and the effect of spironolactone on hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP11B2; Gene Expression; In Situ Hybridization; Liv | 2000 |
Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers.
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Erythrocytes; Female; Liver; Liver Cirrhosis; Ma | 2000 |
Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide.
Topics: Animals; Carbon Tetrachloride; Collagen; Enzyme Activation; Immunoblotting; Liver Cirrhosis; Male; P | 2001 |
Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.
Topics: Analysis of Variance; Animals; Bradykinin; Carbon Tetrachloride; Hypertension, Portal; Inflammation; | 2001 |
Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide.
Topics: Animals; Carbon Tetrachloride; Cell Cycle Proteins; Disease Models, Animal; Liver Cirrhosis; Male; R | 2001 |
The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Division; Hepatocytes; Imm | 2001 |
Role of nitric oxide (NO) in pulmonary dysfunction associated with experimental cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Endothelium, Vascular; Enzyme Inhibitors; Liver Ci | 2001 |
JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Dimerization; Hepatocytes; Interleukin-6; Liver Cirr | 2001 |
Effects of ischemia and reperfusion on oxidative stress in hepatic cirrhosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Ischemia; Lipid Peroxides; Liver; Liver Circulation; Liver Cirrhosis; | 2000 |
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine.
Topics: Actins; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Collagen; Endotoxins; Gadolinium; G | 2001 |
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; DNA Primers; Extracellular Matrix; Extrace | 2001 |
A rat model of liver cirrhosis and esophageal varices.
Topics: Animals; Carbon Tetrachloride; Collateral Circulation; Disease Models, Animal; Esophageal and Gastri | 2001 |
NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension.
Topics: Animals; Carbon Tetrachloride; Collagen; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Nitrate | 2001 |
Cirrhosis and carcinoma of the liver in male rats given subcutaneous carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Injections, Subcutaneous; Liver Cirrhosis; Liver Neoplas | 1970 |
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.
Topics: Animals; Anti-Allergic Agents; Apoptosis; Calcium; Carbon Tetrachloride; Chlorpromazine; Collagen; C | 2001 |
Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Separation; Collagen; Coloring Agents; Cyt | 2001 |
The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2001 |
Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection.
Topics: Adrenergic beta-Antagonists; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Di | 2001 |
[The coordinated expression of laminin and its integrin receptor in hepatic sinusoidal capillarization].
Topics: Animals; Antigens, CD; Carbon Tetrachloride; Disease Models, Animal; Integrin alpha6; Laminin; Liver | 2001 |
Expression changes of activin A in the development of hepatic fibrosis.
Topics: Activins; Animals; Carbon Tetrachloride; Gene Expression; Immunohistochemistry; Inhibin-beta Subunit | 2001 |
Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Division; Col | 2001 |
Inhibition of rat liver fibrogenesis through noradrenergic antagonism.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Carbon Tetrachloride; Liver; Liver Cirrhos | 2002 |
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Dose-Response Relationship, | 2002 |
Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers.
Topics: Actins; Animals; Carbon Tetrachloride; Cholestasis, Extrahepatic; Fibroblasts; Glial Fibrillary Acid | 2002 |
5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzoquinones; Carbon Tetrachloride; Cysteine; Leukotriene Ant | 2002 |
[Dynamic expression of tenascin in rat liver during liver fibrogenesis induced by CCl(4)].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix Proteins; Image Processi | 2002 |
[Effects of glycyrrhetinic acid and IFN-alpha on HSCs collagen metabolism in rat fibrotic liver of varying stages].
Topics: Alcohols; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Disease Models, Animal; | 2002 |
[Experimental study of the therapeutic effect of interferon-alpha on liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Collagen Type IV; Disease Models, Animal; Hyaluronic Acid; Inflammati | 2002 |
Neutrophil migration during liver cirrhosis in rabbits.
Topics: Animals; Carbon Tetrachloride; Chemotaxis, Leukocyte; Leukocyte Count; Liver Cirrhosis; Male; Neutro | 2002 |
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
Topics: Animals; Benzhydryl Compounds; Bile Ducts; Carbon Tetrachloride; Cell Division; Cells, Cultured; Col | 2002 |
Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044.
Topics: Animals; Arteries; Blood Pressure; Carbon Tetrachloride; Collagen; Collagenases; Endothelin Receptor | 2002 |
Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular | 1975 |
[Change in the mitotic activity of hepatocytes and resorption of necrotic areas in the formation of liver cirrhosis].
Topics: Animals; Carbon Tetrachloride; Iodized Oil; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Mi | 1976 |
Changes of gastric blood flow in experimentally induced cirrhosis of the liver.
Topics: Animals; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis; Male; Microspheres; Rabbits; Regional | 1978 |
Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carbon Tetrachloride; Carcinogens; Diet; Fatty Acids, Essential; | 1976 |
Effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices.
Topics: Animals; Azetidines; Carbon Tetrachloride; Carboxylic Acids; Colchicine; Collagen; In Vitro Techniqu | 1975 |
Rate-limiting steps in drug metabolism by microsomes from CCl-4-cirrhotic rat liver.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Carbon Tetrachloride; Corticosterone; Cytochr | 1975 |
The source of ascitic fluid in experimental cirrhosis in the rat.
Topics: Animals; Ascitic Fluid; Carbon Tetrachloride; Fluoresceins; Fluoroscopy; Liver Cirrhosis; Male; Peri | 1975 |
[Experimental study of preventing liver cirrhosis by using four kinds of Chinese herbs].
Topics: Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Female; Liver Cirrhosis; Male; Plant | 1992 |
[Pathomorphology of acute and chronic stages of CCl4-induced liver fibrosis: immunohistochemical and in situ hybridization studies].
Topics: Animals; Carbon Tetrachloride; Extracellular Matrix Proteins; Humans; Immunoenzyme Techniques; In Si | 1992 |
[Experimental study on yiqi-huoxue therapy of liver fibrosis].
Topics: Alanine Transaminase; Animals; Astragalus propinquus; Carbon Tetrachloride; Collagen; Drugs, Chinese | 1992 |
The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Connective Tissue; Liver; Liver Cirrhosis; Male; Microscopy | 1991 |
Systemic histopathology of rats with CCl4-induced hepatic cirrhosis.
Topics: Animals; Carbon Tetrachloride; Heart Atria; Liver Cirrhosis; Macrophages; Male; Monocytes; Organ Spe | 1991 |
Preventive effect of malotilate on carbon tetrachloride-induced liver damage and collagen accumulation in the rat.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Female; Fibroblasts; Glucosyltransferases; | 1987 |
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Che | 1985 |
Changes in coenzyme Q level in mitochondria of cirrhotic rat liver.
Topics: Animals; Carbon Tetrachloride; Electron Transport Complex IV; Liver Cirrhosis; Mitochondria, Liver; | 1985 |
Cryptic adenosine triphosphatase activities in plasma membranes of CCl4-cirrhotic rats. Its modulation by changes in cholesterol/phospholipid ratios.
Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1985 |
Glycosaminoglycan containing fat-storing cells in hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Glycosaminoglycans; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; | 1988 |
Lysosomal enzymes in plasma, liver and spleen from rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; beta-N-Acetylhexosaminidases; Bilirubin; | 1985 |
The effect of carbon tetrachloride-induced cirrhosis of the liver on fibrinogen-bound sialic acid and sialyltransferase activity in the rat.
Topics: Animals; Carbon Tetrachloride; Fibrinogen; Liver Cirrhosis; Male; N-Acetylneuraminic Acid; Protein B | 1986 |
Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1985 |
Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators.
Topics: Alprostadil; Animals; Blood Pressure; Carbon Tetrachloride; Cytochalasin B; In Vitro Techniques; Iso | 1985 |
Effects of volatile anesthetics or fentanyl on hepatic function in cirrhotic rats.
Topics: Alanine Transaminase; Anesthetics; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Fenta | 1985 |
Long-term effects of carbon tetrachloride and sodium phenobarbitone administration on rat serum proteins.
Topics: Alpha-Globulins; Animals; Blood Proteins; Body Weight; Carbon Tetrachloride; gamma-Globulins; Immuno | 1973 |
Functional structure of the cirrhotic rat liver.
Topics: Animals; Bile Ducts; Capillaries; Carbon Tetrachloride; Cell Nucleus; Cytoplasm; Freeze Drying; Incl | 1974 |
Gamma-glutamyl transpeptidase: a clinical and experimental study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon | 1972 |
Gastric secretion in canines with cirrhosis and ascites.
Topics: Animals; Ascites; Carbon Tetrachloride; Catheterization; Dogs; Female; Gastric Juice; Gastric Mucosa | 1969 |
Some aspects of connective tissue development in the course of CC14-induced liver cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Connective Tissue; Connective Tissue | 1970 |
[Changes in the bile secretion and bile ductules in the course of development of experimental hepatitis and liver cirrhosis].
Topics: Acute Disease; Adenosine Triphosphatases; Animals; Bile; Bile Ducts; Carbon Tetrachloride; Chemical | 1971 |
[Synergic oncogenic effect of 2-N-fluorenylacetamide and carbon tetrachloride on rat liver].
Topics: Adenoma, Bile Duct; Amides; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Fluo | 1968 |
[Synergic oncogenic action of 4-dimethylaminoazobenzole and carbon tetrachloride on rat liver].
Topics: Adenoma, Bile Duct; Animals; Carbon Tetrachloride; Carcinogens; Drug Synergism; Female; Liver Cirrho | 1968 |
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1970 |
The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Ethanol; Fatty Li | 1971 |
Collagenase activity in experimental hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Electrophoresis, Polyacrylamide Gel; Female; Liver Cirrhosi | 1974 |
Effect of carbon tetrachloride induced progressive liver damage on drug-metabolizing enzymes and cytochrome P-450 in rat liver.
Topics: Aniline Compounds; Animals; Body Weight; Carbon Tetrachloride; Cytochromes; Glucosephosphate Dehydro | 1971 |
[The induction of liver cirrhosis in rats by simultaneous administration of carbon tetrachloride and phenobarbitone (author's transl)].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Liver Cirrhosis; Male | 1973 |
Experimental siderosis and liver injury in the rhesus monkey.
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Haplorhini; | 1972 |
Effect of the production of experimental cirrhosis in rats on serum aminotransferase levels.
Topics: Alanine; Animals; Aspartic Acid; Carbon Tetrachloride; Drug Synergism; Kinetics; Liver Cirrhosis; Ph | 1972 |
The effect of pancreatectomy and other agents on iron absorption and storage in the rat.
Topics: Absorption; Animals; Atrophy; Carbon Tetrachloride; Ethionine; Female; Hemosiderin; Iron; Iron Isoto | 1973 |
Biochemical and histological correlations of regeneration after experimental liver damage: significance of cirrhosis.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Chromatin; Chromosomes; Endoplasmic Reticulum; Glycogen | 1973 |
[Effect of chlorophos on the development and course of experimental pathology of the liver].
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Synergism; Liver; Liver Cirrho | 1973 |
Liver arterialization with portacaval shunt in the cirrhotic rat.
Topics: Alanine Transaminase; Ammonia; Angiography; Animals; Arteries; Carbon Tetrachloride; Liver; Liver Ci | 1974 |
The effects of azathioprine on CCl4 induced cirrhosis in the rat.
Topics: Adenosine Triphosphate; Animals; Azathioprine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1974 |
The relation between experimental liver carcinoma and liver cirrhosis induced by simultaneous administration of p-dimethylaminoazobenzene and carbon tetrachloride.
Topics: Animals; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms; p-Dimethylamino | 1967 |
Experimental liver carcinoma and liver cirrhosis induced by p-dimethylaminoazobenzene after preliminary carbon tetrachloride injections.
Topics: Animals; Azo Compounds; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis; Liver Neoplasms; | 1967 |
The relation between experimental liver carcinoma and liver cirrhosis induced by successive administration of p-dimethylaminoazobenzene and carbon tetrachloride.
Topics: Animals; Body Weight; Carbon Tetrachloride; Hyperplasia; Liver; Liver Cirrhosis; Liver Neoplasms; p- | 1967 |
Antigenic structure of connective tissue.
Topics: Animals; Antigens; Basement Membrane; Blood Vessels; Carbon Tetrachloride; Connective Tissue; Fluore | 1969 |
Porta-pulmonary venous anastomoses in experimental cirrhosis of the liver in rats.
Topics: Animals; Arteries; Barium Sulfate; Carbon Tetrachloride; Coronary Vessels; Esophagus; Hypoxia; Liver | 1972 |
[Pathogenesis of hepatogenic ulcer].
Topics: Animals; Carbon Tetrachloride; Duodenal Ulcer; Gastric Acidity Determination; Gastric Juice; Gastric | 1971 |
[Liver cell regeneration during the development of liver cirrhosis in rats, induced by tetrachlormethane].
Topics: Animals; Carbon Tetrachloride; Histocytochemistry; Liver; Liver Cirrhosis; Liver Cirrhosis, Experime | 1971 |
Hepatic lesions in aged rats given carbon tetrachloride and 3-methylcholanthrene.
Topics: Age Factors; Animals; Body Weight; Budd-Chiari Syndrome; Carbon Tetrachloride; Drug Synergism; Femal | 1971 |
Effect of carbon tetrachloride induced progressive liver damage on the metabolism of hexobarbital and bilirubin in vivo.
Topics: Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hexob | 1971 |
Effect of zinc sulphate on carbon tetrachloride hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hexobarbital; Injections, Intraperito | 1969 |
[Does norepinephrine also annul the antiatherogenic action of hepatic cirrhosis].
Topics: Animals; Arteriosclerosis; Carbon Tetrachloride; Cholesterol; Liver Cirrhosis; Norepinephrine; Rabbi | 1970 |
Effect of sirepar on experimental cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fatty Liver; Liver; Liver Cirrhosis; Liver Ex | 1970 |
Cellular effects of carbon tetrachloride.
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver | 1971 |
Disturbances in the permeability of the cerebral blood vessels in experimental hepatic encephalopathy.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Diseases; Carbon Tetrachloride; Female; | 1971 |
Carbon tetrachloride induced cirrhosis. Effect of age and sex.
Topics: Age Factors; Animals; Body Weight; Carbon Tetrachloride; Injections, Subcutaneous; Liver Cirrhosis; | 1968 |
Calcium absorption in the normal, bile-duct ligated, and cirrhotic rat, with observations on the effect of long- and medium-chain triglycerides.
Topics: Animals; Bile; Bone and Bones; Calcium; Calcium Isotopes; Carbon Tetrachloride; Intestinal Absorptio | 1968 |
Some obserations on the effect of CCl4 on normal and regenerating liver.
Topics: Animals; Carbon Tetrachloride; Depression, Chemical; Enzymes; Hepatectomy; Histocytochemistry; Liver | 1968 |
A composite canine model of cirrhosis.
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Dogs; Hypertension, Portal; Liver; Liver Cir | 1969 |
[Experimental hepathic enchalopathy in rat. Clinical and electrocorticographic study].
Topics: Animals; Ataxia; Brain Diseases; Carbon Tetrachloride; Cerebral Cortex; Coma; Cyanosis; Electroencep | 1969 |
In numero studies in a cell renewal system. Periodically adjusted cell renewal process.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Computers; DNA; Kinetics; Liver Cirrhosis; Liver Cir | 1965 |
[Hormonal control of collagen metabolism].
Topics: Anabolic Agents; Animals; Carbon Tetrachloride; Collagen; Liver Cirrhosis; Methenolone; Osteoporosis | 1965 |
Fatty cirrhosis in the rat.
Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats; | 1966 |
Hepatic vascular changes in human and experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Artery; Hepatic Veins; Humans; Liver Circulation; Liver Cirrh | 1966 |
[Cytochemical studies on leukocytes in human liver cirrhosis and experimental cirrhosis in the rabbit in regard to exstirpation of the spleen].
Topics: Alkaline Phosphatase; Amides; Animals; Carbon Tetrachloride; Esterases; Hepatitis; Histocytochemistr | 1966 |