carbon tetrachloride has been researched along with Inflammation in 191 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice." | 8.31 | Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models. ( Fujino, C; Hayashi, K; Katsura, T; Kubo, Y; Kuzu, T; Ueshima, S, 2023) |
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 8.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| " Here, we characterized the effects of an adenosine compound (IFC-305) on preventing fibrosis and liver inflammation." | 8.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 7.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 7.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| " NaHS protected liver function, attenuated liver fibrosis, inhibited inflammation, and reduced the portal pressure, evidenced by the alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), albumin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and soluble intercellular adhesion molecule (ICAM)-1, liver histology, hepatic hydroxyproline content and α-smooth muscle actin (SMA) expression." | 7.77 | Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. ( Dong, X; Jiang, H; Jiang, X; Kang, K; Kanwar, JR; Li, J; Pan, S; Qiao, H; Sun, X; Tan, G; Zhao, M, 2011) |
| " After N-acetylcysteine plus deferoxamine treatment, hepatocellular necrosis and inflammatory infiltration induced by carbon tetrachloride were greatly decreased." | 7.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| "Glabridin is an active ingredient extracted from the root of Glycyrrhiza glabra." | 5.72 | Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice. ( Gu, J; Li, H; Sun, J; Xu, W; Yuan, N; Zhang, H; Zhang, L, 2022) |
| "Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively." | 5.48 | Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities." | 5.39 | Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. ( Dang, X; Dong, L; Jia, M; Jiang, J; Lu, X; Shi, H; Zhao, G; Zhao, J, 2013) |
| " Fibrotic mice received a specific FAP inhibitor (FAPi) at 2 doses orally for 2 weeks during parenchymal fibrosis progression (6 weeks of carbon tetrachloride) and regression (2 weeks off carbon tetrachloride), and with biliary fibrosis (Mdr2-/-)." | 4.31 | Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis. ( Abe, H; Aslam, M; Jia, JD; Kim, YO; Klein, T; Park, KS; Schuppan, D; Yan, XZ; Yang, AT; You, H; Zhao, XY, 2023) |
| "Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice." | 4.31 | Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023) |
| " Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice." | 4.31 | Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models. ( Fujino, C; Hayashi, K; Katsura, T; Kubo, Y; Kuzu, T; Ueshima, S, 2023) |
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 4.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| " Here, we characterized the effects of an adenosine compound (IFC-305) on preventing fibrosis and liver inflammation." | 4.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis." | 4.31 | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |
| "Our findings demonstrate that didymin can ameliorate liver fibrosis, which is mainly attributed to the inhibition of ERS, inflammation, and glycerophospholipid metabolism." | 4.12 | Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics. ( Fang, B; Huang, Q; Li, C; Li, Y; Lin, X; Xiong, Y, 2022) |
| " Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats." | 3.91 | Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response. ( Krtinic, D; Mirkovic, MV; Nickovic, V; Radovic, M; Rancic, M; Ristic, L; Sokolovic, D; Toskic, DR; Vujnovic Zivkovic, ZN; Zivkovic, JB, 2019) |
| "Our findings indicate that fraxetin is effective in preventing liver fibrosis through inhibiting inflammation and hepatocytes apoptosis which is associated with regulating NF-κB/IκBα, MAPKs and Bcl-2/Bax signaling pathways in rats." | 3.91 | Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways. ( Gu, Y; Li, S; Song, F; Wang, R; Wang, Y; Wu, B; Yuan, Y, 2019) |
| "We therefore examined the biochemical, histopathological and molecular effects of the 5-HT7 receptor agonist and antagonist on inflammatory liver fibrogenesis in animal models of progressive cirrhosis: a mouse model induced by carbon tetrachloride (CCl4) and in Hep3b cells." | 3.85 | Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Unal, D, 2017) |
| "5-Fluorouracil (5-FU) is the chemotherapeutic agent of first choice for the treatment ofcolorectal cancer, however, treatment-related liver toxicity remains a major concern." | 3.85 | Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice. ( Gao, L; Huo, X; Li, C; Sun, G; Wang, C, 2017) |
| " As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP against carbon tetrachloride (CCl4)-induced liver injury." | 3.85 | Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. ( Bao, X; Brenner, DA; Cong, M; Fan, X; Jia, J; Kisseleva, T; Liu, T; Wang, P; You, H; Zhai, Q; Zhang, D; Zhao, W; Zhuang, H, 2017) |
| "Curcumin significantly attenuated inflammation and fibrosis, as revealed by histological and biochemical analysis." | 3.83 | Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1. ( Chen, J; Huang, R; Liu, Y; Pan, Z; Sun, Z; Wang, G; Wang, J; Wu, C; Wu, H; Xia, J; Xiong, Y; Yan, X; Zhang, Z, 2016) |
| " Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment." | 3.83 | CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. ( Aldridge, V; Buckley, CD; Croft, AP; Fear, J; Garg, A; Haldar, D; Hedegaard, D; Henderson, NC; Naylor, AJ; Newsome, PN; Reynolds, GM; Weston, CJ; Wilhelm, A, 2016) |
| "The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats." | 3.80 | Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage. ( Bassani, VL; Bortolin, RC; Gasparotto, J; Gelain, DP; Girardi, CS; Kunzler, A; Moreira, JC; Moresco, KS; Rabelo, TK; Raseira, Mdo C; Schnorr, CE; Somensi, N; Vizzotto, M; Yatsu, FK; Zanotto-Filho, A, 2014) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 3.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| " C57BL/6N mice were fed a high-fat diet (HFD) to develop obesity and were either administered carbon tetrachloride (CCl4 ) eight times (0." | 3.79 | A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice. ( Ishikawa, F; Kado, S; Kano, M; Kobayashi, T; Kubota, N; Masuoka, N; Miyazaki, K; Nagata, Y, 2013) |
| " In this study, the diethylnitrosamine (DEN)-induced liver tumor model and the chronic carbon tetrachloride (CCl(4))-induced liver fibrosis model were both used to investigate the role of STAT3 in liver tumorigenesis." | 3.77 | Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. ( Gao, B; Lafdil, F; Miller, AM; Niu, J; Park, O; Sun, Z; Wang, H; Wang, L; Yin, S, 2011) |
| " NaHS protected liver function, attenuated liver fibrosis, inhibited inflammation, and reduced the portal pressure, evidenced by the alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), albumin, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and soluble intercellular adhesion molecule (ICAM)-1, liver histology, hepatic hydroxyproline content and α-smooth muscle actin (SMA) expression." | 3.77 | Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. ( Dong, X; Jiang, H; Jiang, X; Kang, K; Kanwar, JR; Li, J; Pan, S; Qiao, H; Sun, X; Tan, G; Zhao, M, 2011) |
| "6 g/kg bw) significantly reduced the serum levels of alanine aminotransferase and aspartate aminotransferase in rats treated with CCl4, and also decreased the thiobarbituric acid reactive substances, hydroxyproline and excessive inflammation in the livers of CCl4-treated rats." | 3.76 | Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats. ( Hsu, CC; Hsu, CL; Yen, GC, 2010) |
| " Liver oxidative stress and inflammation were examined by detecting the liver malondialdehyde level and glutathione and superoxide dismutase activity, and serum tumour necrosis factor-alpha level, respectively." | 3.76 | Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice. ( Dong, W; Hao, X; Ren, X; Yan, F; Yang, L, 2010) |
| " This study determined the role of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase deficiency in the development of hepatocellular necrosis, inflammation, and apoptosis in relation to fibrosis produced by chronic carbon tetrachloride (CCl(4)) administration." | 3.75 | Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. ( Aram, G; Liu, X; Mezey, E; Potter, JJ; Torbenson, MS; Wang, L, 2009) |
| " As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used." | 3.74 | Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008) |
| " After N-acetylcysteine plus deferoxamine treatment, hepatocellular necrosis and inflammatory infiltration induced by carbon tetrachloride were greatly decreased." | 3.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| " PIRE produced significant antiinflammatory activity against glucose oxidase-induced paw oedema (in vivo), inhibited hydroxyl radical and superoxide generation, lysis of erythrocytes induced by hydrogen peroxide, CCl(4)-induced lipid peroxidation and also dioxygenase activity of lipoxygenase (both in the presence and absence of hydrogen peroxide)." | 3.71 | Antioxidant activity of the methanol fraction of Pluchea indica root extract. ( Bhattacharjee, S; Dhara, AK; Nag Chaudhuri, AK; Pal, S; Sen, T, 2002) |
| " Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents." | 3.66 | [Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981) |
| "Saffron can attenuate liver fibrosis by inhibiting the JAK/STAT3 pathway and the activation of hepatic stellate cell, providing a theoretical basis for the development of new anti-fibrotic drugs." | 1.91 | Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway. ( Han, Y; Huang, L; Qiu, Q; Su, W; Wang, Z; Yan, J; Yue, S; Zhou, Q, 2023) |
| "Glabridin is an active ingredient extracted from the root of Glycyrrhiza glabra." | 1.72 | Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice. ( Gu, J; Li, H; Sun, J; Xu, W; Yuan, N; Zhang, H; Zhang, L, 2022) |
| "In the latter 3 groups, liver fibrosis was established by treatment with CCl4." | 1.62 | Dietary fiber regulates intestinal flora and suppresses liver and systemic inflammation to alleviate liver fibrosis in mice. ( Li, MM; Li, XA; Nie, D; Zhou, Y; Zuo, L, 2021) |
| "Liver fibrosis was induced by injection of CCl4 in male Sprague-Dawley rats, and those rats were then treated with astilbin at different concentrations." | 1.62 | Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. ( Fan, XP; Sun, XH; Wang, ZH; Zhang, H, 2021) |
| "However, its roles in liver fibrosis remain to be determined." | 1.62 | Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis. ( Chen, J; Hu, R; Li, J; Sun, J; Xing, X; Zhou, Q; Zhu, Z, 2021) |
| "Liver fibrosis is a serious chronic disease that developed by a coordinated interplay of many cell types, but the underlying signal transduction in individual cell type remains to be characterized." | 1.56 | RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines. ( Fan, Y; Ge, S; Huang, W; Ji, R; Liu, Z; Lu, C; Wei, J; Xiao, M; Zhang, J; Zhou, D, 2020) |
| "Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease." | 1.51 | New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019) |
| "However, persistent injuries cause liver fibrosis (LF) to evolve into cirrhosis, which promotes the development of hepatocellular carcinoma (HCC)." | 1.51 | Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. ( Bobbala, D; Ilangumaran, S; Kandhi, R; Khan, MGM; Mafanda, EK; Menendez, A; Nandi, M; Ramanathan, S, 2019) |
| "Maltol pretreatment groups did not show significant cell nuclear condensation and fragmentation, indicating that maltol inhibited CCl₄-induced cell apoptosis." | 1.48 | The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response. ( He, YF; Hou, JG; Jiang, S; Li, W; Liu, W; Ren, S; Wang, YP; Wang, Z; Zhou, YD, 2018) |
| "Adding PSTPIP2 expression alleviates liver fibrosis and hepatic inflammation in mice by regulating macrophage polarization." | 1.48 | PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. ( Huang, C; Huang, HM; Li, HD; Li, J; Li, WX; Li, XF; Lv, XW; Meng, XM; Pan, XY; Wang, H; Wu, XQ; Yang, Y; Zhang, L, 2018) |
| "Treatment with SR9243 significantly reduced the severity of hepatic inflammation and ameliorated hepatic fibrosis; simultaneously, body weight, serum glucose, and plasma lipid levels were controlled effectively." | 1.48 | Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis. ( Chang, S; Huang, FZ; Huang, P; Jiang, XL; Kaluba, B; Mao, LF; Tang, XF; Zhang, ZP, 2018) |
| "However, possible splenic effects on liver fibrosis development are unclear." | 1.46 | Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice. ( Aoyama, T; Ikejima, K; Kokubu, S; Kon, K; Kuwahara-Arai, K; Miyazaki, A; Okubo, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| "Liver fibrosis is a global health problem and previous studies have demonstrated that reactive oxygen species (ROS) play important roles in fibrogenesis." | 1.43 | Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. ( Gao, Y; Gu, J; Kong, X; Sun, X; Wen, Y; Xia, Q; Yu, C; Yu, Y, 2016) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| "Liver fibrosis was observed in CCl4 (800 ml/kg)-induced mice, and high viability was observed in CCl4 (10 mM)-intoxicated HSCs." | 1.43 | Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro. ( Bao, YF; Chu, X; Dong, YS; Guo, H; Jiang, YM; Luan, YC; Wang, H; Yang, F; Zhang, JP; Zhang, X; Zhang, YY, 2016) |
| "To induce liver fibrosis, male Wistar rats received CCl4 (2 ml/kg/2 times/week; i." | 1.43 | Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways. ( Abd el Aziz, GM; El-Desouky, MA; Hasan, IH; Hozayen, WG, 2016) |
| "Liver fibrosis was induced by repeated intraperitoneal injection of carbon tetrachloride." | 1.42 | Macrophage autophagy protects against liver fibrosis in mice. ( Chobert, MN; Denaës, T; El-Benna, J; Lodder, J; Lotersztajn, S; Pawlotsky, JM; Teixeira-Clerc, F; Wan, J, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "Liver is a vital organ for the detoxification of toxic substances present in the body and hepatic injury is associated with excessive exposure to toxicants." | 1.40 | Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. ( Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Imam, F; Iqbal, M; Nadeem, A, 2014) |
| "Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use." | 1.40 | Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model. ( Chanderasekharan, H; Chheda, TK; Madanahalli, JR; Marikunte, VV; Moolemath, Y; Oommen, AM; Sadasivan, SK; Shivakumar, P, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Sprague-Dawley rats were induced liver fibrosis by carbon tetrachloride (CCl4) for 10 weeks with or without BML-111, and the histopathology and collagen content were employed to quantify hepatic necro-inflammation and fibrosis." | 1.39 | BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats. ( Cai, ZY; Huang, YH; Min, WP; Sha, J; Wang, HM; Xu, FY; Yan, D; Yu, ZJ; Zhou, XY, 2013) |
| "Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities." | 1.39 | Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. ( Dang, X; Dong, L; Jia, M; Jiang, J; Lu, X; Shi, H; Zhao, G; Zhao, J, 2013) |
| "Analysis of MSC and IL-6 treatment on liver fibrosis was measured by histopathology, PAS, TUNEL and Sirius red staining, RT-PCR, and liver function tests for Bilirubin and Alkaline Phosphatase (ALP)." | 1.39 | Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice. ( Ali, G; Khan, M; Khan, SN; Mohsin, S; Nasir, GA; Riazuddin, S; Shams, S, 2013) |
| "• Liver MR T1ρ decreased when liver fibrosis and injury regressed." | 1.38 | MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication. ( Ahuja, AT; Chu, ES; Deng, M; Go, MY; Teng, GJ; Wang, YX; Wong, HL; Yu, J; Yuan, J; Zhao, F, 2012) |
| "To address this issue, we induced liver fibrosis by carbon tetrachloride (CCl(4)) chronic administration to 8-week- and 15-month-old mice." | 1.37 | Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response. ( Abdoun, E; Collin de l'Hortet, A; Cosson, C; Fromenty, B; Gilgenkrantz, H; Guidotti, JE; Mahrouf-Yorgov, M; Mitchell, C; Slama, A, 2011) |
| "Since Sept4(-/-)mice are prone to liver fibrosis, we aimed to identify the unknown molecular network underlying liver fibrosis by probing the association between loss of Sept4 and accelerated transdifferentiation of HSCs." | 1.37 | Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells. ( Asechi, H; Hatano, E; Iwaisako, K; Kinoshita, M; Nagata, H; Narita, M; Sato, F; Taura, K; Uemoto, S; Yanagida, A, 2011) |
| "Here we show that hepatocellular carcinoma (HCC) arising spontaneously against a background of hepatitis occurred more frequently in Nucling-knockout (KO) mice than wild-type (WT) mice." | 1.36 | Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. ( Fukui, K; Hayashi, Y; Ishimaru, N; Kaji, R; Kim, SM; Liu, L; Mukai-Sakai, R; Sakai, T; Sano, N; Teng, X; Tran, NH, 2010) |
| "Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment." | 1.36 | Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. ( Hu, Y; Jian, P; Liu, C; Liu, P; Peng, J; Sun, M; Tao, Q; Wu, JZ; Yang, W, 2010) |
| "Liver fibrosis was induced in mice by administering carbon tetrachloride (CCl4) continuously for 10 weeks." | 1.33 | Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice. ( Chou, WY; Concejero, AM; Jawan, B; Kuo, HM; Lee, TH; Lu, CN; Wang, CH; Wu, CL, 2006) |
| " Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use." | 1.31 | The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity. ( Blazka, ME; Bruccoleri, A; Gallucci, RM; Luster, MI; Matheson, JM; Simeonova, PP; Yucesoy, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (6.81) | 18.7374 |
| 1990's | 4 (2.09) | 18.2507 |
| 2000's | 22 (11.52) | 29.6817 |
| 2010's | 103 (53.93) | 24.3611 |
| 2020's | 49 (25.65) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, B | 3 |
| Zheng, X | 1 |
| Li, X | 6 |
| Wang, C | 5 |
| Li, L | 5 |
| Tang, Z | 1 |
| Cui, H | 1 |
| Li, Z | 5 |
| Chen, L | 4 |
| Ma, X | 2 |
| Abdelghffar, EA | 1 |
| Obaid, WA | 1 |
| Alamoudi, MO | 1 |
| Mohammedsaleh, ZM | 1 |
| Annaz, H | 1 |
| Abdelfattah, MAO | 1 |
| Sobeh, M | 1 |
| Di Paola, R | 1 |
| Modafferi, S | 1 |
| Siracusa, R | 1 |
| Cordaro, M | 1 |
| D'Amico, R | 1 |
| Ontario, ML | 1 |
| Interdonato, L | 1 |
| Salinaro, AT | 1 |
| Fusco, R | 1 |
| Impellizzeri, D | 1 |
| Calabrese, V | 1 |
| Cuzzocrea, S | 1 |
| Xu, B | 3 |
| Zheng, J | 1 |
| Tian, X | 1 |
| Yuan, F | 1 |
| Liu, Z | 4 |
| Zhou, Y | 4 |
| Yang, Z | 1 |
| Ding, X | 1 |
| Kim, SM | 2 |
| Song, GY | 1 |
| Shim, A | 1 |
| Lee, JH | 1 |
| Eom, CB | 1 |
| Liu, C | 7 |
| Yang, YM | 1 |
| Seki, E | 2 |
| Li, Y | 3 |
| Li, C | 3 |
| Xiong, Y | 2 |
| Fang, B | 1 |
| Lin, X | 1 |
| Huang, Q | 1 |
| Li, J | 9 |
| Xian, L | 1 |
| Zheng, R | 1 |
| Wang, Y | 7 |
| Wan, X | 1 |
| Liu, Y | 8 |
| Engelmann, C | 1 |
| Habtesion, A | 1 |
| Hassan, M | 1 |
| Kerbert, AJ | 1 |
| Hammerich, L | 1 |
| Novelli, S | 1 |
| Fidaleo, M | 1 |
| Philips, A | 1 |
| Davies, N | 1 |
| Ferreira-Gonzalez, S | 1 |
| Forbes, SJ | 1 |
| Berg, T | 1 |
| Andreola, F | 1 |
| Jalan, R | 1 |
| Zhang, L | 5 |
| Zhang, H | 6 |
| Gu, J | 2 |
| Xu, W | 1 |
| Yuan, N | 1 |
| Sun, J | 3 |
| Li, H | 5 |
| Shaban, NZ | 3 |
| Awad, OM | 3 |
| Fouad, GM | 3 |
| Hafez, AM | 3 |
| Abdul-Aziz, AA | 3 |
| El-Kot, SM | 3 |
| Yang, AT | 2 |
| Kim, YO | 2 |
| Yan, XZ | 2 |
| Abe, H | 2 |
| Aslam, M | 2 |
| Park, KS | 2 |
| Zhao, XY | 2 |
| Jia, JD | 2 |
| Klein, T | 2 |
| You, H | 3 |
| Schuppan, D | 2 |
| Oates, JR | 1 |
| Sawada, K | 1 |
| Giles, DA | 1 |
| Alarcon, PC | 1 |
| Damen, MSMA | 1 |
| Szabo, S | 1 |
| Stankiewicz, TE | 1 |
| Moreno-Fernandez, ME | 1 |
| Divanovic, S | 1 |
| Fujino, C | 1 |
| Kuzu, T | 1 |
| Kubo, Y | 1 |
| Hayashi, K | 1 |
| Ueshima, S | 1 |
| Katsura, T | 1 |
| Sharma, A | 1 |
| Wang, J | 5 |
| Gandhi, CR | 1 |
| Pu, S | 1 |
| Zhang, J | 4 |
| Ren, C | 1 |
| Zhou, H | 3 |
| Wu, Y | 3 |
| Yang, S | 1 |
| Cao, F | 1 |
| Rathod, DK | 1 |
| Chakravarthy, C | 1 |
| Suryadevara, SS | 1 |
| Patil, RS | 1 |
| Wagdargi, SS | 1 |
| Jiao, Y | 1 |
| Zhao, Z | 2 |
| Xiao, D | 1 |
| Wan, S | 1 |
| Wu, T | 1 |
| Li, T | 1 |
| Li, P | 1 |
| Zhao, R | 2 |
| Chen, H | 1 |
| Li, S | 6 |
| Pan, B | 1 |
| Liu, K | 1 |
| Yu, H | 1 |
| Ma, C | 1 |
| Qi, H | 2 |
| Zhang, Y | 14 |
| Huang, X | 2 |
| Ouyang, D | 1 |
| Xie, Z | 1 |
| Long, Z | 1 |
| Guo, T | 1 |
| Chen, C | 4 |
| Zhang, G | 1 |
| Zhu, J | 1 |
| Yun, T | 1 |
| Jing, T | 1 |
| Zang, X | 1 |
| Zhou, D | 3 |
| Li, K | 1 |
| Zhao, Y | 3 |
| Wang, W | 2 |
| Xie, J | 1 |
| Yang, J | 3 |
| Xu, H | 2 |
| Ke, Z | 1 |
| Kan, N | 1 |
| Zheng, E | 1 |
| Qiu, Y | 2 |
| Huang, M | 1 |
| Zheng, F | 1 |
| Basit, A | 1 |
| Zhuang, H | 2 |
| Chen, J | 9 |
| da Silva, DJ | 1 |
| Ferreira, RR | 1 |
| da S Ferreira, G | 1 |
| Barbosa, RFS | 1 |
| Marciano, JS | 1 |
| Camani, PH | 1 |
| Souza, AG | 1 |
| Rosa, DS | 1 |
| Ge, Q | 1 |
| Norvell, MR | 1 |
| Porter, M | 1 |
| Ricco, MH | 1 |
| Koonce, RC | 1 |
| Hogan, CA | 1 |
| Basler, E | 1 |
| Wong, M | 1 |
| Jeffres, MN | 1 |
| Osorio-Tejada, JL | 1 |
| Rebrov, E | 1 |
| Hessel, V | 1 |
| Bacevicius, J | 1 |
| Taparauskaite, N | 1 |
| Kundelis, R | 1 |
| Sokas, D | 1 |
| Butkuviene, M | 1 |
| Stankeviciute, G | 1 |
| Abramikas, Z | 1 |
| Pilkiene, A | 1 |
| Dvinelis, E | 1 |
| Staigyte, J | 1 |
| Marinskiene, J | 1 |
| Audzijoniene, D | 1 |
| Petrylaite, M | 1 |
| Jukna, E | 1 |
| Karuzas, A | 1 |
| Juknevicius, V | 1 |
| Jakaite, R | 1 |
| Basyte-Bacevice, V | 1 |
| Bileisiene, N | 1 |
| Badaras, I | 1 |
| Kiseliute, M | 1 |
| Zarembaite, G | 1 |
| Gudauskas, M | 1 |
| Jasiunas, E | 1 |
| Johnson, L | 1 |
| Marozas, V | 1 |
| Aidietis, A | 1 |
| Okui, N | 1 |
| Okui, MA | 1 |
| Neveln, NK | 1 |
| Khattab, M | 1 |
| Hagan, JL | 1 |
| Fortunov, RM | 1 |
| Sundgren, NC | 1 |
| Venugopal, V | 1 |
| Kalpana, ML | 1 |
| Deenadayalan, B | 1 |
| Venkateswaran, ST | 1 |
| Maheshkumar, K | 1 |
| Ebrahimi, M | 1 |
| Ahangar, N | 1 |
| Zamani, E | 1 |
| Shaki, F | 1 |
| Osei, R | 1 |
| Titeux, H | 1 |
| Del Río, M | 1 |
| Ruiz-Peinado, R | 1 |
| Bielak, K | 1 |
| Bravo, F | 1 |
| Collet, C | 1 |
| Cools, C | 1 |
| Cornelis, JT | 1 |
| Drössler, L | 1 |
| Heym, M | 1 |
| Korboulewsky, N | 1 |
| Löf, M | 1 |
| Muys, B | 1 |
| Najib, Y | 1 |
| Nothdurft, A | 1 |
| Pach, M | 1 |
| Pretzsch, H | 1 |
| Ponette, Q | 1 |
| Sepúlveda-García, P | 1 |
| Alabi, A | 1 |
| Álvarez, K | 1 |
| Rojas, L | 1 |
| Mella, A | 1 |
| Gonçalves, LR | 1 |
| André, MR | 1 |
| Machado, RZ | 1 |
| Müller, A | 1 |
| Monti, G | 1 |
| Meester, M | 1 |
| Tobias, TJ | 1 |
| van den Broek, J | 1 |
| Meulenbroek, CB | 1 |
| Bouwknegt, M | 1 |
| van der Poel, WHM | 1 |
| Stegeman, A | 1 |
| Abdullahi, IN | 1 |
| Lozano, C | 1 |
| Simon, C | 1 |
| Latorre-Fernandez, J | 1 |
| Zarazaga, M | 1 |
| Torres, C | 2 |
| Sauer, FG | 1 |
| Lange, U | 1 |
| Schmidt-Chanasit, J | 1 |
| Kiel, E | 1 |
| Wiatrowska, B | 1 |
| Myczko, Ł | 1 |
| Lühken, R | 1 |
| Quero, S | 1 |
| Serras-Pujol, M | 1 |
| Párraga-Niño, N | 1 |
| Navarro, M | 1 |
| Vilamala, A | 1 |
| Puigoriol, E | 1 |
| de Los Ríos, JD | 1 |
| Arqué, E | 1 |
| Serra-Pladevall, J | 1 |
| Romero, A | 1 |
| Molina, D | 1 |
| Paredes, R | 1 |
| Pedro-Botet, ML | 1 |
| Reynaga, E | 1 |
| Meng, X | 1 |
| Chu, W | 1 |
| Tang, Y | 1 |
| Chen, Y | 2 |
| Li, N | 1 |
| Feng, Y | 1 |
| Xiao, L | 1 |
| Guo, Y | 1 |
| Agliani, G | 1 |
| Giglia, G | 1 |
| de Bruin, E | 2 |
| van Mastrigt, T | 1 |
| Blom, R | 1 |
| Sikkema, RS | 2 |
| Kik, M | 1 |
| Koopmans, MPG | 2 |
| Gröne, A | 1 |
| Van den Brand, JMA | 1 |
| de Bellegarde de Saint Lary, C | 1 |
| Kasbergen, LMR | 1 |
| Bruijning-Verhagen, PCJL | 1 |
| van der Jeugd, H | 1 |
| Chandler, F | 1 |
| Hogema, BM | 1 |
| Zaaijer, HL | 1 |
| van der Klis, FRM | 1 |
| Barzon, L | 1 |
| Ten Bosch, Q | 1 |
| Visser, LG | 1 |
| Aiying, W | 1 |
| Ju, L | 1 |
| Cilin, W | 1 |
| Yuxuan, H | 1 |
| Baojun, Y | 1 |
| Jian, T | 1 |
| Shuhua, L | 1 |
| La, DD | 1 |
| Pham, KTT | 1 |
| Lai, HT | 1 |
| Tran, DL | 1 |
| Van Bui, C | 1 |
| Nguyen, PHT | 1 |
| Chang, SW | 1 |
| Um, MJ | 1 |
| Nguyen, DD | 1 |
| Wongsomboon, V | 1 |
| Webster, GD | 1 |
| Yang, Y | 6 |
| Chen, Z | 1 |
| Lv, T | 1 |
| Dong, K | 1 |
| Qi, Y | 1 |
| Cao, S | 1 |
| Chen, T | 3 |
| Wang, H | 9 |
| Wang, L | 8 |
| Zhao, P | 1 |
| Zhang, X | 8 |
| Lu, X | 2 |
| Qiu, Z | 1 |
| Qi, B | 2 |
| Yao, R | 1 |
| Huang, Y | 3 |
| Wei, T | 1 |
| Fan, Z | 1 |
| Baran, E | 1 |
| Birczyński, A | 1 |
| Dorożyński, P | 1 |
| Kulinowski, P | 1 |
| He, X | 1 |
| Qiao, T | 1 |
| Zhang, Z | 2 |
| Liu, H | 2 |
| Wang, S | 3 |
| Wang, X | 5 |
| Møller, JM | 1 |
| Boesen, L | 1 |
| Hansen, AE | 1 |
| Kettles, K | 1 |
| Løgager, V | 1 |
| Zeng, S | 1 |
| Kan, E | 1 |
| Souza, BG | 1 |
| Choudhary, S | 1 |
| Vilela, GG | 1 |
| Passos, GFS | 1 |
| Costa, CACB | 1 |
| Freitas, JD | 1 |
| Coelho, GL | 1 |
| Brandão, JA | 1 |
| Anderson, L | 1 |
| Bassi, ÊJ | 1 |
| Araújo-Júnior, JX | 1 |
| Tomar, S | 1 |
| Silva-Júnior, EFD | 1 |
| Hindle, S | 1 |
| Brien, MÈ | 1 |
| Pelletier, F | 1 |
| Giguère, F | 1 |
| Trudel, MJ | 1 |
| Dal Soglio, D | 1 |
| Kakkar, F | 1 |
| Soudeyns, H | 1 |
| Girard, S | 1 |
| Boucoiran, I | 1 |
| Regueira-Marcos, L | 1 |
| Muñoz, R | 1 |
| García-Depraect, O | 1 |
| Gong, S | 1 |
| Liang, M | 1 |
| Shi, R | 1 |
| Tsabedze, N | 1 |
| Mpanya, D | 1 |
| Bailly, C | 1 |
| Nel, S | 1 |
| Grinter, S | 1 |
| Ramsay, M | 1 |
| Krause, A | 1 |
| Wells, Q | 1 |
| Manga, P | 1 |
| Zhao, C | 2 |
| Shao, X | 1 |
| Shou, Q | 1 |
| Ma, SJ | 1 |
| Gokyar, S | 1 |
| Graf, C | 1 |
| Stollberger, R | 1 |
| Wang, DJ | 1 |
| Bakky, MAH | 1 |
| Tran, NT | 1 |
| Zhang, M | 2 |
| Liang, H | 1 |
| Ma, H | 1 |
| Zheng, H | 1 |
| Ren, Y | 1 |
| Jia, Z | 1 |
| Liang, C | 1 |
| Xu, D | 1 |
| Ye, N | 1 |
| Lyu, T | 1 |
| Fan, W | 1 |
| Wu, S | 2 |
| Mortimer, RJG | 1 |
| Pan, G | 1 |
| Qin, S | 1 |
| Zeng, H | 1 |
| Wu, Q | 1 |
| Li, Q | 4 |
| Zeeshan, M | 1 |
| Ye, L | 1 |
| Jiang, Y | 2 |
| Zhang, R | 3 |
| Jiang, X | 3 |
| Li, M | 1 |
| Chen, W | 1 |
| Chou, WC | 1 |
| Dong, GH | 1 |
| Li, DC | 1 |
| Zeng, XW | 1 |
| Cai, X | 1 |
| Song, Y | 1 |
| Gao, J | 1 |
| Wang, Z | 8 |
| Jiang, W | 1 |
| Meng, Z | 1 |
| Niu, Y | 1 |
| Sheng, Z | 1 |
| Liu, X | 7 |
| Chen, X | 5 |
| Jia, K | 1 |
| Zhang, C | 5 |
| Liao, H | 1 |
| Jung, J | 2 |
| Sung, E | 1 |
| Chung, H | 1 |
| Zhang, JZ | 1 |
| Zhu, AX | 1 |
| Shen, L | 2 |
| Godfrey, J | 1 |
| Sunseri, N | 1 |
| Cooper, A | 1 |
| Yu, J | 3 |
| Varlamova, A | 1 |
| Zarubin, D | 1 |
| Popov, Y | 1 |
| Jacobson, C | 1 |
| Postovalova, E | 1 |
| Xiang, Z | 1 |
| Nomie, K | 1 |
| Bagaev, A | 1 |
| Venkataraman, G | 1 |
| Zha, Y | 1 |
| Tumuluru, S | 1 |
| Smith, SM | 1 |
| Kline, JP | 1 |
| Zhu, B | 1 |
| Sun-Waterhouse, D | 1 |
| You, L | 1 |
| Zhang, B | 1 |
| Jiang, Z | 1 |
| Wu, Z | 1 |
| Hu, J | 1 |
| Rao, J | 1 |
| Hasnan, NSN | 1 |
| Mohamed, MA | 1 |
| Nordin, NA | 1 |
| Wan Ishak, WNR | 1 |
| Kassim, MB | 1 |
| Xiao, T | 1 |
| Yin, X | 1 |
| Zhang, T | 1 |
| Wei, C | 1 |
| Chen, S | 2 |
| Jiang, L | 3 |
| Xiang, P | 1 |
| Ni, S | 1 |
| Tao, F | 1 |
| Tan, X | 1 |
| Wang, XH | 1 |
| Liu, XQ | 2 |
| Cai, DC | 1 |
| Hu, P | 1 |
| Zhao, WP | 1 |
| Wang, LM | 1 |
| Wang, JY | 1 |
| Xie, S | 2 |
| Jin, JH | 1 |
| Wang, B | 3 |
| Li, WN | 1 |
| Li, HY | 1 |
| Chen, YT | 1 |
| Ding, HT | 1 |
| Gan, J | 1 |
| Ji, CF | 1 |
| Mao, XR | 1 |
| Wang, JT | 1 |
| Lyu, CY | 1 |
| Shi, YF | 1 |
| Liao, Y | 1 |
| He, YL | 1 |
| Shu, L | 1 |
| Li, JF | 1 |
| McGlone, ER | 1 |
| Carey, IM | 1 |
| Currie, A | 1 |
| Mahawar, K | 1 |
| Welbourn, R | 1 |
| Ahmed, AR | 1 |
| Pring, C | 1 |
| Small, PK | 1 |
| Khan, OA | 1 |
| Dai, Y | 2 |
| Pu, M | 1 |
| Lei, M | 1 |
| Zhang, XY | 1 |
| Sun, SP | 1 |
| Sang, YQ | 1 |
| Xue, XS | 1 |
| Min, QQ | 1 |
| Lasheen, ESR | 1 |
| Rashwan, MA | 1 |
| Azer, MK | 1 |
| Mafakheri, F | 1 |
| Asakereh, A | 1 |
| Khoee, S | 1 |
| Kamankesh, M | 1 |
| Sun, SK | 1 |
| Mottram, LM | 1 |
| Gouder, T | 1 |
| Stennett, MC | 1 |
| Hyatt, NC | 1 |
| Corkhill, CL | 1 |
| Lai, Q | 1 |
| Hamamoto, K | 1 |
| Luo, H | 1 |
| Zaroogian, Z | 1 |
| Zhou, C | 1 |
| Lesperance, J | 1 |
| Zha, J | 1 |
| Guryanova, OA | 1 |
| Huang, S | 1 |
| Zhao, M | 2 |
| Wang, M | 1 |
| Domínguez-López, M | 1 |
| de Vaca, RP | 1 |
| Rodríguez-Aguilera, JR | 1 |
| Guerrero-Celis, N | 1 |
| Velasco-Loyden, G | 1 |
| de Sánchez, VC | 1 |
| Lin, W | 1 |
| Cai, Y | 2 |
| Huang, Z | 1 |
| Yan, T | 1 |
| Qiuling, L | 1 |
| Qilin, Y | 1 |
| Cheng, Y | 3 |
| Minping, Z | 1 |
| Kangning, W | 1 |
| Enhua, X | 1 |
| Geervliet, E | 1 |
| Terstappen, LWMM | 1 |
| Bansal, R | 2 |
| Zeng, HH | 1 |
| Ma, M | 1 |
| Wang, YL | 1 |
| Chen, MH | 1 |
| Huang, DB | 1 |
| Kaufmann, B | 1 |
| Mogler, C | 1 |
| Zhong, S | 1 |
| Yin, Y | 1 |
| Cheng, Z | 2 |
| Schmid, RM | 1 |
| Friess, H | 1 |
| Hüser, N | 1 |
| von Figura, G | 1 |
| Hartmann, D | 1 |
| Huang, L | 2 |
| Han, Y | 1 |
| Qiu, Q | 1 |
| Yue, S | 1 |
| Zhou, Q | 3 |
| Su, W | 1 |
| Yan, J | 2 |
| Maeso-Díaz, R | 1 |
| Boyer-Diaz, Z | 1 |
| Lozano, JJ | 1 |
| Ortega-Ribera, M | 1 |
| Peralta, C | 1 |
| Bosch, J | 1 |
| Gracia-Sancho, J | 1 |
| Bian, M | 1 |
| He, J | 1 |
| Jin, H | 1 |
| Lian, N | 1 |
| Shao, J | 1 |
| Guo, Q | 1 |
| Zhang, F | 2 |
| Zheng, S | 1 |
| Fortier, M | 1 |
| Cadoux, M | 1 |
| Boussetta, N | 1 |
| Pham, S | 1 |
| Donné, R | 1 |
| Couty, JP | 1 |
| Desdouets, C | 1 |
| Celton-Morizur, S | 1 |
| Radovic, M | 1 |
| Ristic, L | 1 |
| Krtinic, D | 1 |
| Rancic, M | 1 |
| Nickovic, V | 1 |
| Vujnovic Zivkovic, ZN | 1 |
| Zivkovic, JB | 1 |
| Mirkovic, MV | 1 |
| Toskic, DR | 1 |
| Sokolovic, D | 1 |
| Qu, H | 1 |
| Gao, X | 1 |
| Wang, ZY | 1 |
| Yi, JJ | 1 |
| Cao, D | 1 |
| Min, L | 1 |
| Wang, G | 2 |
| Zhou, Z | 3 |
| Qi, J | 1 |
| Zhao, J | 2 |
| Lim, CW | 1 |
| Kim, JW | 1 |
| Kim, B | 1 |
| Zhao, T | 1 |
| Deng, Y | 1 |
| Hou, L | 1 |
| Fan, X | 2 |
| Lin, L | 1 |
| Zhao, W | 2 |
| Jiang, K | 2 |
| Sun, C | 2 |
| Zhang, K | 2 |
| Shen, W | 1 |
| Liu, D | 1 |
| Qin, H | 1 |
| Yang, B | 1 |
| Du, B | 1 |
| Yun, X | 1 |
| Huang, W | 2 |
| Wei, J | 1 |
| Ji, R | 1 |
| Ge, S | 1 |
| Xiao, M | 1 |
| Fan, Y | 2 |
| Lu, C | 1 |
| Trivikram, TM | 1 |
| Niu, ML | 1 |
| Wcisło, P | 1 |
| Ubachs, W | 1 |
| Salumbides, EJ | 1 |
| Sharp, BR | 1 |
| Bowman, DMJS | 1 |
| Palese, A | 1 |
| Bressan, V | 1 |
| Hayter, M | 1 |
| Watson, R | 1 |
| Bozorov, TA | 1 |
| Li, DX | 1 |
| Zhou, P | 1 |
| Wen, XJ | 1 |
| Ding, Y | 1 |
| Zhang, DY | 1 |
| Yoshida, H | 1 |
| Koike, M | 1 |
| Tada, Y | 1 |
| Nakata, K | 1 |
| Hino, A | 1 |
| Fuji, S | 1 |
| Masaie, H | 1 |
| Oka, C | 1 |
| Higeno, A | 1 |
| Idota, A | 1 |
| Yamasaki, T | 1 |
| Ishikawa, J | 1 |
| Nekoohesh, L | 2 |
| Ghahremani, MH | 1 |
| Rostami, S | 1 |
| Nikbakht, M | 1 |
| Naemi, R | 1 |
| Mohammadi, S | 1 |
| Ghadyani Nejad, L | 1 |
| Mousavi, SA | 1 |
| Vaezi, M | 1 |
| Alimoghaddam, K | 1 |
| Chahardouli, B | 1 |
| El-Neanaey, WA | 1 |
| Swelem, RS | 1 |
| Ghallab, OM | 1 |
| Mohamed Abu-Shelou, S | 1 |
| Javadzadeh Shahshahani, H | 1 |
| Hayati, A | 1 |
| Abbasnezhad, A | 1 |
| Habibi, M | 1 |
| Abdolkarimi, B | 1 |
| Zare, S | 1 |
| Fazeli Moghadam, E | 1 |
| Choghakhori, R | 1 |
| Asmaa, MJS | 1 |
| Al-Jamal, HA | 1 |
| Hussein, AR | 1 |
| Yahaya, BH | 1 |
| Hassan, R | 1 |
| Hussain, FA | 1 |
| Shamsuddin, S | 1 |
| Johan, MF | 1 |
| Guo, C | 1 |
| Zhu, H | 1 |
| Xi, J | 1 |
| He, P | 1 |
| Cuenca, J | 1 |
| Wang, N | 1 |
| Liang, Z | 1 |
| Sun, H | 1 |
| Gutierrez, B | 1 |
| Xi, X | 1 |
| Arro, J | 1 |
| Fan, P | 1 |
| Londo, J | 1 |
| Cousins, P | 1 |
| Fei, Z | 1 |
| Zhong, GY | 1 |
| Bell, K | 1 |
| Rosignol, I | 1 |
| Sierra-Filardi, E | 1 |
| Rodriguez-Muela, N | 1 |
| Schmelter, C | 1 |
| Cecconi, F | 1 |
| Grus, F | 1 |
| Boya, P | 1 |
| Hahn, MA | 1 |
| Von Elert, E | 1 |
| Kang, Y | 1 |
| Liu, J | 2 |
| Zhang, WS | 1 |
| Xiong, JH | 1 |
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| Tashiro, F | 2 |
| Yamato, E | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantitative Diagnosis of Liver Fibrosis on Multiparametric MRI[NCT03176797] | 300 participants (Anticipated) | Interventional | 2017-05-03 | Enrolling by invitation | |||
| Galectin-3 as a Predictor for Thromboembolic Formation in Patients With Non Valvular Atrial Fibrillation Assessed by CHA₂DS₂-VASc Scoring[NCT03413072] | 140 participants (Anticipated) | Observational | 2018-06-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for carbon tetrachloride and Inflammation
| Article | Year |
|---|---|
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation.
Topics: Administration, Inhalation; Animals; Antioxidants; Ascorbic Acid; Brain; Carbon Tetrachloride; Carra | 2013 |
Free-radical mechanisms in tissue injury.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Cell Survival; Chemical and Drug Induced Liver Injury; C | 1984 |
Carbon tetrachloride: genetic effects and other modes of action.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Cytochrome P-450 Enzyme | 1996 |
187 other studies available for carbon tetrachloride and Inflammation
| Article | Year |
|---|---|
Design, synthesis and activity evaluation of prodrug form JBP485 and Vitamin E for alleviation of NASH.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Design; Fibrosis; | 2022 |
Thymus fontanesii attenuates CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Flavonoids; Inflammation; Lip | 2022 |
S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Dr | 2022 |
Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cytokines; Female; Gastrointestinal Microbiome; Humans; | 2022 |
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4.
Topics: Animals; Carbon Tetrachloride; Chemokine CCL3; Chemokine CCL4; Fibrosis; Hepatic Stellate Cells; Hya | 2022 |
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Endoplasmic Reticulum Stress; Flavonoids; Glycerophospholi | 2022 |
Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro.
Topics: Aged; Aging; Animals; Canthaxanthin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Humans; Hydrog | 2022 |
Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF.
Topics: Acute-On-Chronic Liver Failure; Animals; Carbon Tetrachloride; Disease Models, Animal; Galactosamine | 2022 |
Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Fibronectins; Hepatic Stellate Cells; Infla | 2022 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla | 2023 |
Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expressi | 2023 |
CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Inflammation; Lipopolysaccharide Receptors; L | 2023 |
Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Topics: Animals; Carbon Tetrachloride; Diet; Fibrosis; Hepatic Stellate Cells; Humans; Inflammation; Liver; | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Inflammation; Interleukin-6; | 2024 |
Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound.
Topics: Adenosine; Animals; Carbon Tetrachloride; Cytokines; Fibrosis; Inflammation; Liver; Liver Cirrhosis; | 2023 |
Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Fibrosis; Glutamate-Cysteine Ligase; Glutat | 2023 |
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosi | 2023 |
Hepatocyte survival and proliferation by fibroblast growth factor 7 attenuates liver inflammation, and fibrogenesis during acute liver injury via paracrine mechanisms.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Collagen; Culture Media, Conditioned; Fibroblast | 2023 |
Hyperoside attenuates carbon tetrachloride-induced hepatic fibrosis via the poly(ADP-ribose)polymerase-1-high mobility group protein 1 pathway.
Topics: Adenosine Diphosphate Ribose; Animals; Carbon Tetrachloride; HMGB1 Protein; Inflammation; Liver Cirr | 2023 |
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis; | 2023 |
Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway.
Topics: Animals; Carbon Tetrachloride; Crocus; Fibrosis; Hepatic Stellate Cells; Inflammation; Liver; Liver | 2023 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li | 2019 |
Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Cin | 2019 |
Hepatospecific ablation of p38α MAPK governs liver regeneration through modulation of inflammatory response to CCl
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Ch | 2019 |
Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response.
Topics: Acute Lung Injury; Animals; Antioxidants; Arginine; Carbon Tetrachloride; Inflammation; Melatonin; N | 2019 |
Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents, Local | 2020 |
Mediator MED23 regulates inflammatory responses and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemokine CCL5; Chemokine CXCL10; Disease Models, Animal; | 2019 |
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice.
Topics: Aminopyridines; Animals; Bile Ducts; Carbon Tetrachloride; Hepatic Stellate Cells; I-kappa B Kinase; | 2020 |
Genipin Ameliorates Carbon Tetrachloride-Induced Liver Injury in Mice via the Concomitant Inhibition of Inflammation and Induction of Autophagy.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2019 |
Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Image Processing, Computer-Assisted; Inflamma | 2020 |
Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome.
Topics: Animals; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Diterpenes, Kaurane; Hepatic Stell | 2020 |
RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines.
Topics: Animals; Carbon Tetrachloride; Cytokines; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic | 2020 |
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Benzyl Alcohols; Carbon Tetrachloride; Disease Models | 2020 |
Dihydro-stilbene gigantol relieves CCl
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Bibenzyls; Carbon Tetrachlori | 2020 |
Smad3 gene C-terminal phosphorylation site mutation aggravates CCl
Topics: Acute Disease; Animals; Body Weight; Breeding; Carbon Tetrachloride; Chronic Disease; Embryo, Mammal | 2020 |
Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2020 |
Mesenchymal stem cells ameliorate oxidative stress, inflammation, and hepatic fibrosis via Nrf2/HO-1 signaling pathway in rats.
Topics: Animals; Carbon Tetrachloride; Inflammation; Liver; Liver Cirrhosis; Mesenchymal Stem Cells; NF-E2-R | 2021 |
Pilea umbrosa ameliorate CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2020 |
Dietary fiber regulates intestinal flora and suppresses liver and systemic inflammation to alleviate liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Dietary Fiber; Gastrointestinal Microbiome; Inflammation; Liver; Live | 2021 |
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Che | 2020 |
MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Disease | 2020 |
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dru | 2021 |
Taxifolin, Extracted from Waste
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachloride; Dose-Response Rel | 2021 |
Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Cytokines; Dose-Response Relationship, Drug; Flavonols; Glu | 2021 |
Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice.
Topics: Animals; Carbon Tetrachloride; Chenodeoxycholic Acid; Diet; Inflammation; Liver; Liver Cirrhosis; Ma | 2021 |
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Galactosamine; Hum | 2021 |
Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Cytokines; Disease Models, A | 2021 |
Structural characterization and hepatoprotective activity of a galactoglucan from Poria cocos.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Constitutive Andro | 2021 |
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Collagen; Disease Models, Ani | 2021 |
Hepatoprotective effect of Spirulina platensis against carbon tetrachloride-induced liver injury in male rats.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2021 |
Downregulation of fibrosis and inflammatory signalling pathways in rats liver
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2021 |
Hepatoprotective Effect of Carboxymethyl Pachyman in Fluorouracil-Treated CT26-Bearing Mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Apopto | 2017 |
Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carbon Tetrachloride; Inflammation | 2017 |
Apocynin prevented inflammation and oxidative stress in carbon tetra chloride induced hepatic dysfunction in rats.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; | 2017 |
Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrachloride; Cell Line; Cells, Cultured; Chem | 2017 |
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi | 2017 |
Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride‑induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; Cells, | 2017 |
Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Inf | 2017 |
Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats.
Topics: Animals; Benzoates; Carbon Tetrachloride; Disease Models, Animal; Epoxide Hydrolases; Hypertension, | 2018 |
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Topics: Animals; Carbon Tetrachloride; Cell Line; Inflammation; Liver; Liver Cirrhosis; Male; Metalloendopep | 2018 |
Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Carbon Tetrachloride; Caspase 3; Ceramides; | 2018 |
Cav-1 deficiency promotes liver fibrosis in carbon tetrachloride (CCl
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Caveolin 1 | 2018 |
Liver X Receptor Inverse Agonist SR9243 Suppresses Nonalcoholic Steatohepatitis Intrahepatic Inflammation and Fibrosis.
Topics: Animals; Bile Ducts; Blood Glucose; Body Weight; Carbon Tetrachloride; Cytokines; Hepatocytes; Infla | 2018 |
Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Line; Chemica | 2018 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2018 |
PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.
Topics: 5' Untranslated Regions; Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carbon Tetrachlo | 2018 |
Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Chemokine CCL2; Collagen Type I; Collagen Type I, alpha 1 Cha | 2019 |
The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Flavorin | 2018 |
The hydroethanolic Litchi chinensis leaf extract alleviate hepatic injury induced by carbon tetrachloride (CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Inflamm | 2018 |
Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl
Topics: Aldehydes; Ammonia; Animals; Brain; Carbon Tetrachloride; Cytokines; Inflammation; Liver Cirrhosis; | 2019 |
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expre | 2016 |
Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.
Topics: Animals; Apoptosis; Becaplermin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibr | 2019 |
Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Coumarins; Inflammation; Liver | 2019 |
Combination of CCl
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; | 2019 |
Resveratrol improves CCL4-induced liver fibrosis in mouse by upregulating endogenous IL-10 to reprogramme macrophages phenotype from M(LPS) to M(IL-4).
Topics: Animals; Carbon Tetrachloride; Cell Polarity; Inflammation; Interleukin-10; Interleukin-4; Kupffer C | 2019 |
Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Coculture Techniques; Female; Gene Expression Regulation; | 2013 |
A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Anim | 2013 |
BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Down-Regulation; Gene Expression; Heptanoic Acids; | 2013 |
Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo.
Topics: A Kinase Anchor Proteins; Animals; Carbon Tetrachloride; Cell Cycle Proteins; Cell Movement; Cell Pr | 2013 |
The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats.
Topics: Allyl Compounds; Animals; Apoptosis; Base Sequence; Blotting, Western; Carbon Tetrachloride; Caspase | 2014 |
Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2014 |
Antihepatotoxic effect of tadehaginoside, extracted from Tadehagi triquetrum (L.), against CCl4-lesioned rats through activating the Nrf2 signaling pathway and attenuating the inflammatory response.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coumaric Acids; Fabaceae; Gen | 2014 |
Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Line; Collagen Type III; Hepatic Stell | 2014 |
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.
Topics: Animals; Aptamers, Nucleotide; Carbon Tetrachloride; Chemokine CCL2; Disease Models, Animal; Disease | 2014 |
Naringenin attenuates CCl4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavanones; Gene Expression R | 2014 |
Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2014 |
Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-κB activities.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cyclooxygenase 2; DNA Damage; Inflammation; Interleukin | 2014 |
Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fast Foods; Female; Gene Expression Profiling | 2014 |
Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts.
Topics: Abrus; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Carrageenan; Chemical an | 2014 |
Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Blood Glucose; | 2014 |
[Differential proteome analysis of carbon tetrachloride-induced mouse liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Computational Biology; Down-Regulation; Inflammation; Liver Cirrhosis | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
The protective effect of Esculentoside A on experimental acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2014 |
Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl₄-induced injury.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Complemen | 2015 |
Two-signal requirement for growth-promoting function of Yap in hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Carbon Tetrachloride; Cell Cycle P | 2015 |
Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2015 |
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Effects of polysaccharides from selenium-enriched Pyracantha fortuneana on mice liver injury.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Macrophage autophagy protects against liver fibrosis in mice.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cell Lineage; Culture Media, | 2015 |
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Antigens, CD; Antigens, Neoplasm; Becaplermin; Carbon | 2016 |
Hepatic Progenitor Cells Contribute to the Progression of 2-Acetylaminofluorene/Carbon Tetrachloride-Induced Cirrhosis via the Non-Canonical Wnt Pathway.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Differentiation; Female; Inflammation; Li | 2015 |
Quercetin protects mouse liver against CCl₄-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrach | 2015 |
Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner.
Topics: Adult; Aged; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Mov | 2015 |
Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regula | 2016 |
Cultured Mycelium Cordyceps sinensis allevi¬ates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells.
Topics: Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Cordyceps; Drugs, Chinese Herbal; Inflammatio | 2016 |
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice.
Topics: Age Factors; Aging; Animals; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Chemical and Drug | 2016 |
Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Su | 2016 |
Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chronic Disease; Culture Media, Condit | 2016 |
Telmisartan ameliorates carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Carbon Te | 2017 |
Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Proliferation; Chemokine CCL2; Chemokine CCL5; Chole | 2016 |
Protective effects of L-carnosine on CCl4 -induced hepatic injury in rats.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury | 2016 |
Beneficial Effects of Silymarin After the Discontinuation of CCl4-Induced Liver Fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2016 |
Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Ly; Carbon Tetrachloride; Chemokine CCL2 | 2016 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2016 |
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Fibrosis; Humans; Inflammation; | 2017 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice.
Topics: Adaptation, Physiological; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2017 |
Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Disease Models, Animal; Humans; Indoles; Inflammation; Liv | 2017 |
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Disease Models, Animal; Hepato | 2009 |
Inflammasome-mediated regulation of hepatic stellate cells.
Topics: Actins; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Carbon Tetrachloride; CARD Signal | 2009 |
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
The potential of metabolomic approaches for investigating mode(s) of action of xenobiotics: case study with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cytotoxins; DNA Damage; Humans; Inflammation; Lip | 2011 |
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Chemical and Dru | 2010 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice.
Topics: Animals; Aprotinin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Rela | 2010 |
Effectiveness of the PPARγ agonist, GW570, in liver fibrosis.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Hepatic Stellat | 2010 |
In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Artemisia absinthium; Asparta | 2010 |
Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch. et Sav.) Ching.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose- | 2010 |
Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol; Cy | 2010 |
Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Dimethylnitrosamine; Fibrosis; Hepatic St | 2010 |
A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression.
Topics: Animals; Carbon Tetrachloride; Cryptomeria; Cyclooxygenase 2 Inhibitors; Dermatitis; Dinoprostone; H | 2011 |
Placenta extract promote liver regeneration in CCl4-injured liver rat model.
Topics: Actins; Albumins; Alkyl and Aryl Transferases; Animals; ATP-Binding Cassette Transporters; Carbon Te | 2011 |
Inflammation does not always kill hepatocytes during liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2011 |
Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response.
Topics: Aging; Animals; Carbon Tetrachloride; Cell Proliferation; Chronic Disease; Disease Susceptibility; H | 2011 |
Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats.
Topics: Acetylcarnitine; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Ascorbic Acid; A | 2011 |
S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2012 |
Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis.
Topics: Animals; Carbon Tetrachloride; DNA Damage; Fibrosis; Gene Deletion; Gene Expression Regulation, Neop | 2011 |
Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.
Topics: Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Gene Expression Profi | 2011 |
Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Pressure; Carbon Tetrachloride; Cy | 2011 |
Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Movement; Chimer | 2012 |
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Indu | 2012 |
MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Progression; Inflammation; Liver; Liver Cirrhosis | 2012 |
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Chlorogenic Acid; Cytokines; Enzyme-Linked Immunosorbent Assay; Gene | 2013 |
Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2013 |
Antioxidant activity of the methanol fraction of Pluchea indica root extract.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ant | 2002 |
[Cell metabolism and inflammation. VI. Liver respiration after administration in vivo of carbon tetrachloride].
Topics: Carbon Tetrachloride; Hepatitis; Inflammation; Liver | 1956 |
INFLAMMATORY REACTIVITY AND CARCINOGENESIS.
Topics: Aniline Compounds; Animals; Azo Compounds; Carbon Tetrachloride; Carcinogenesis; Carcinogens; Fluore | 1963 |
[Dynamics of the changes in the lymphatic vessels of the liver in dogs and white rats following experimental inflammation of the liver].
Topics: Adrenocorticotropic Hormone; Animals; Carbon Tetrachloride; Dogs; Ergot Alkaloids; Hepatitis; Hepati | 1961 |
Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.
Topics: Blotting, Western; Carbon Tetrachloride; Cell Line; Cell Line, Tumor; Chemokine CXCL11; Chemokines, | 2004 |
Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Deferoxamine; Hydrocarbons; Inflammatio | 2004 |
Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromodeoxyuridine; Carbon | 2005 |
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Tetrachloride; Carbon Tetrachlo | 2005 |
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.
Topics: Animals; Carbon Tetrachloride; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assa | 2005 |
Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice.
Topics: Actins; alpha-MSH; Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cyclooxygenase 2; Electro | 2006 |
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibroblasts; Galectin 3; Humans; Inflammation; Liver; Liver Cirrhosis | 2006 |
Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Hydroxyproline; Inflammation; Liver Cirrh | 2006 |
Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell | 2006 |
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Topics: Animals; Carbon Tetrachloride; Digestive System; Disease Models, Animal; DNA; Gene Deletion; Hepatec | 2007 |
Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibrosis; Genes, | 2008 |
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Cryptomeria; Cyclo | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli | 2008 |
[Changes in the anti-heparin activity of platelet-free plasma in rats with induced inflammation and after administration of CC14 (author's transl)].
Topics: Animals; Blood Coagulation Factors; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In | 1982 |
A bovine muscle extract with anti-cirrhotic and anti-inflammatory properties in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cattle; Collagen; Female; Inflammation; Liv | 1981 |
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero | 1981 |
Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation.
Topics: Animals; Carbon Tetrachloride; Gene Expression; Growth Substances; Hepatectomy; Hepatocyte Growth Fa | 1994 |
Pharmacological and pathological studies on Taiwan folk medicine (IX): The hepatoprotective effect of the methanolic extract from echinops grijisii.
Topics: 1-Butanol; Acetates; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biopsy; Butanols; C | 1993 |
The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2000 |
Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.
Topics: Analysis of Variance; Animals; Bradykinin; Carbon Tetrachloride; Hypertension, Portal; Inflammation; | 2001 |
Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Diterpenes; Fluoresc | 2001 |
The in vivo toxicity of carbon tetrachloride and carrageenan on heart microsomes: analysis by Fourier transform infrared spectroscopy.
Topics: Animals; Carbon Tetrachloride; Carrageenan; Cholesterol Esters; Inflammation; Lipid Metabolism; Micr | 2001 |
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Dose-Response Relationship, | 2002 |
[Experimental study of the therapeutic effect of interferon-alpha on liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Collagen Type IV; Disease Models, Animal; Hyaluronic Acid; Inflammati | 2002 |
Dissociation of alpha-macrofetoprotein and alpha-fetoprotein production during experimental injury.
Topics: alpha-Fetoproteins; alpha-Macroglobulins; Animals; Carbon Tetrachloride; Ethionine; Galactosamine; H | 1979 |
Studies on folk medicine "thang-kau-tin" from Taiwan. (I). The anti-inflammatory and liver-protective effect.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carrageenan; Chemi | 1992 |
The course of healing of the inflammatory granuloma in rats after the application of tetrachlormethane and 6-azauridine.
Topics: Animals; Azauridine; Carbon Tetrachloride; Glycoproteins; Granuloma; Hydroxyproline; Inflammation; L | 1985 |
The effect of experimental local inflammation on the action of barbiturates in rat.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carrageenan; Charcoal; Chlordan; Enzyme Induction; Goss | 1972 |
"In vivo" microscopic study of the response of the hepatic microvascular system to carbon tetrachloride poisoning.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Adhesion; Inflammation; Injectio | 1971 |
[Behavior of serum protein fractions--especially of glycoproteins--in an inflammation model under varied response conditions].
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Ceruloplasmin; Disease Models, Animal; Electrophoresi | 1971 |
The inflammatory reaction in chemical injury. I. Increased vascular permeability and erythema induced by various chemicals.
Topics: Acetates; Animals; Benzene; Capillary Permeability; Carbon Tetrachloride; Chloroform; Erythema; Guin | 1966 |