carbon tetrachloride has been researched along with Hepatocellular Carcinoma in 98 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 7.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| " To clarify the role of the sympathetic nervous system in apoptosis that occurs in chronic liver damage and following the promotion of liver cirrhosis, we studied a carbon tetrachloride (CCl4)-induced liver injury model, using spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and chemically sympathectomized WKY." | 7.71 | The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes. ( Akiyama, Y; Hamanaka, Y; Hamasaki, K; Hsu, CT; Ito, M; Naito, S; Nakashima, M; Ohtsuru, A; Sekine, I, 2001) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 5.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| " In the present study, we took advantage of a transgenic mouse (TG221) characterized by microRNA-221 overexpression, with cirrhotic liver background induced by chronic administration of carbon tetrachloride (CCl4)." | 5.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis." | 4.31 | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "We therefore examined the biochemical, histopathological and molecular effects of the 5-HT7 receptor agonist and antagonist on inflammatory liver fibrogenesis in animal models of progressive cirrhosis: a mouse model induced by carbon tetrachloride (CCl4) and in Hep3b cells." | 3.85 | Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Unal, D, 2017) |
| " Here we describe a syngeneic orthotopic HCC model in immunocompetent mice with liver cirrhosis induced by carbon tetrachloride (CCl4) that recapitulates key features of human HCC." | 3.81 | An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. ( Bardeesy, N; Chen, Y; Duda, DG; Fan, C; Hato, T; Huang, P; Jain, RK; Lauwers, GY; Ramjiawan, RR; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2015) |
| "Sorafenib--a broad kinase inhibitor--is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC." | 3.80 | Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. ( Chen, Y; Duda, DG; Duyverman, AM; Hiddingh, L; Huang, P; Huang, Y; Jain, RK; Koppel, C; Lauwers, GY; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2014) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 3.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| " To clarify the role of the sympathetic nervous system in apoptosis that occurs in chronic liver damage and following the promotion of liver cirrhosis, we studied a carbon tetrachloride (CCl4)-induced liver injury model, using spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and chemically sympathectomized WKY." | 3.71 | The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes. ( Akiyama, Y; Hamanaka, Y; Hamasaki, K; Hsu, CT; Ito, M; Naito, S; Nakashima, M; Ohtsuru, A; Sekine, I, 2001) |
| "Hepatic tumors including hepatocellular carcinoma were generated by carbon tetrachloride in transgenic mice carrying a human c-H-ras gene (rasH2 mice)." | 3.69 | Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations. ( Ishii, H; Morizane, T; Saito, H; Sato, R; Tsunematsu, S, 1997) |
| "Using a liver cancer dataset from the International Cancer Genome Consortium, we developed an extensive in silico screening that identified a cluster of adamalysins co-expressed in livers from patients with hepatocellular carcinoma (HCC)." | 1.91 | ADAMTS12 is a stromal modulator in chronic liver disease. ( Arpigny, E; Azar, F; Bonnier, D; Colige, A; Dekky, B; Kalebić, C; Legagneux, V; Monseur, C; Théret, N, 2023) |
| "Treatment of DEN-induced hepatocellular carcinoma Wistar rats with the extract caused significant (p < 0." | 1.56 | Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats. ( Adebayo, AH; Adelani, IB; Adesina, GO; Edokwe, CB; Metibemu, DS; Oseha, OE; Yakubu, OF, 2020) |
| " In the present study, we took advantage of a transgenic mouse (TG221) characterized by microRNA-221 overexpression, with cirrhotic liver background induced by chronic administration of carbon tetrachloride (CCl4)." | 1.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "GSTZ1 deficiency significantly promoted hepatoma cell proliferation and aerobic glycolysis in HCC cells." | 1.51 | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. ( Chen, C; Lei, C; Li, J; Liang, L; Tang, N; Wang, K; Wang, Q; Xia, J; Yang, F; Yang, Y, 2019) |
| "There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents." | 1.46 | Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. ( Asahina, Y; Enomoto, N; Genda, T; Hiasa, Y; Honda, M; Ide, T; Iio, E; Ikeo, K; Isogawa, M; Itoh, Y; Izumi, N; Kajiwara, E; Kaneko, S; Kawada, N; Kawai, Y; Kojima, K; Komori, A; Kondo, Y; Kumada, T; Kurosaki, M; Kusakabe, A; Matsubara, M; Matsuura, K; Nagasaki, M; Nakagawa, M; Namisaki, T; Nishiguchi, S; Nishina, S; Ogawa, S; Sakaida, I; Sakamoto, N; Sawai, H; Shimada, M; Shimada, N; Shirabe, K; Suetsugu, A; Sugihara, J; Takaguchi, K; Tamori, A; Tanaka, E; Tanaka, Y; Tokunaga, K; Tomita, E; Toyoda, H; Watanabe, H; Yoshiji, H, 2017) |
| "Hepatocarcinogenesis was significantly accelerated in the fibrotic livers compared to those of the control, significantly decreasing the life span of the mice." | 1.43 | Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. ( Ahn, SH; Cho, KJ; Chung, SI; Han, KH; Ju, HL; Kim, DY; Moon, H; Ro, SW, 2016) |
| "The progression of liver fibrosis, an intrinsic response to chronic liver injury, is associated with hepatic hypoxia, angiogenesis, abnormal inflammation, and significant matrix deposition, leading to the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.43 | Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. ( Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH, 2016) |
| "Liver fibrosis is characterized by significant accumulation of extracellular matrix (ECM) proteins, mainly fibrillar collagen-I, as a result of persistent liver injury." | 1.43 | Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. ( Arriazu, E; Chen, Y; Conde de la Rosa, L; Ge, X; Magdaleno, F; Nieto, N; Ruiz de Galarreta, M, 2016) |
| "Autophagy is a regulatory pathway in liver fibrosis." | 1.42 | Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. ( Chen, YH; Huang, WP; Hung, TM; Lai, HS; Lee, PH; Lin, CW; Lin, YC; Yuan, RH, 2015) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process." | 1.40 | Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. ( Gao, X; Han, D; Jin, J; Li, F; Luo, S; Lv, G; Ma, N; Qiao, Y; Wang, L; Wu, G; Xiang, Y; Xu, C; Xu, Y; Yan, B; Zhang, Y; Zhao, R, 2014) |
| "The progression of liver fibrosis results in hepatocellular carcinogenesis in later stages." | 1.38 | Global analysis of DNA methylation in early-stage liver fibrosis. ( Iwasaki, N; Komatsu, Y; Ono, W; Waku, T; Yamaguchi, C; Yanagisawa, J, 2012) |
| "The levels of liver cancer markers, including α-fetoprotein and carcinoembryonic antigen, were substantially increased by NDEA treatment." | 1.38 | Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine (NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl(4)(3 mL/kg/week) for 6 weeks, as the promoter of carcinogenic effect." | 1.38 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "Here we show that hepatocellular carcinoma (HCC) arising spontaneously against a background of hepatitis occurred more frequently in Nucling-knockout (KO) mice than wild-type (WT) mice." | 1.36 | Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. ( Fukui, K; Hayashi, Y; Ishimaru, N; Kaji, R; Kim, SM; Liu, L; Mukai-Sakai, R; Sakai, T; Sano, N; Teng, X; Tran, NH, 2010) |
| "Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective." | 1.36 | Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010) |
| "Experimental observations were made on hepatic cancer induced with diethylnitrosamine (DEN) in guinea-pigs." | 1.26 | Immunological aspects of hepatocellular carcinoma in the guinea-pig. ( Desai, HN, 1976) |
| "The frequency of hepatomata was almost equal in the aflatoxin and aflatoxin-carbon tetrachloride group." | 1.25 | Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. ( Lageron, A; Lemonnier, FJ; Scotto, JM; Stralin, HG, 1975) |
| "One of 18 animals developed a hepatoma, but none of the mice given CCl4 in 0." | 1.25 | Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice. ( Inoue, S; Naito, Y; Takizawa, S; Watanabe, H, 1975) |
| "3." | 1.25 | Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. ( Kwan, SW; Morris, HP; Webb, TE, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (23.47) | 18.7374 |
| 1990's | 4 (4.08) | 18.2507 |
| 2000's | 9 (9.18) | 29.6817 |
| 2010's | 44 (44.90) | 24.3611 |
| 2020's | 18 (18.37) | 2.80 |
| Authors | Studies |
|---|---|
| Humpton, TJ | 1 |
| Hall, H | 1 |
| Kiourtis, C | 1 |
| Nixon, C | 1 |
| Clark, W | 1 |
| Hedley, A | 1 |
| Shaw, R | 1 |
| Bird, TG | 1 |
| Blyth, K | 1 |
| Vousden, KH | 1 |
| Shaban, NZ | 1 |
| Yehia, SA | 1 |
| Awad, D | 1 |
| Shaban, SY | 1 |
| Saleh, SR | 1 |
| Márquez-Quiroga, LV | 1 |
| Arellanes-Robledo, J | 1 |
| Vásquez-Garzón, VR | 1 |
| Villa-Treviño, S | 1 |
| Muriel, P | 1 |
| Huang, YH | 1 |
| Lian, WS | 1 |
| Wang, FS | 1 |
| Wang, PW | 1 |
| Lin, HY | 1 |
| Tsai, MC | 1 |
| Yang, YL | 1 |
| Song, Z | 2 |
| Liu, X | 1 |
| Zhang, W | 1 |
| Luo, Y | 1 |
| Xiao, H | 1 |
| Liu, Y | 3 |
| Dai, G | 1 |
| Hong, J | 1 |
| Li, A | 1 |
| Li, J | 3 |
| Xian, L | 1 |
| Zheng, R | 2 |
| Wang, Y | 5 |
| Wan, X | 1 |
| Wang, T | 2 |
| Zhu, J | 1 |
| Gao, L | 1 |
| Wei, M | 1 |
| Zhang, D | 1 |
| Chen, L | 1 |
| Wu, H | 1 |
| Ma, J | 2 |
| Li, L | 2 |
| Zhang, N | 1 |
| Xing, Q | 1 |
| He, L | 1 |
| Hong, F | 1 |
| Qin, S | 1 |
| Wu, B | 1 |
| Feng, J | 1 |
| Guo, J | 1 |
| Wang, J | 2 |
| Xiu, G | 1 |
| Xu, J | 3 |
| Ning, K | 1 |
| Ling, B | 1 |
| Fu, Q | 1 |
| Dekky, B | 1 |
| Azar, F | 1 |
| Bonnier, D | 1 |
| Monseur, C | 1 |
| Kalebić, C | 1 |
| Arpigny, E | 1 |
| Colige, A | 1 |
| Legagneux, V | 1 |
| Théret, N | 1 |
| Wang, B | 1 |
| Kaufmann, B | 1 |
| Mogler, C | 1 |
| Zhong, S | 1 |
| Yin, Y | 1 |
| Cheng, Z | 1 |
| Schmid, RM | 1 |
| Friess, H | 1 |
| Hüser, N | 1 |
| von Figura, G | 1 |
| Hartmann, D | 1 |
| Shankaraiah, RC | 1 |
| Callegari, E | 1 |
| Guerriero, P | 1 |
| Rimessi, A | 1 |
| Pinton, P | 1 |
| Gramantieri, L | 1 |
| Silini, EM | 1 |
| Sabbioni, S | 1 |
| Negrini, M | 1 |
| Wang, Q | 1 |
| Yang, Y | 3 |
| Lei, C | 1 |
| Yang, F | 2 |
| Liang, L | 1 |
| Chen, C | 2 |
| Xia, J | 1 |
| Wang, K | 1 |
| Tang, N | 1 |
| Lu, ZN | 1 |
| Luo, Q | 1 |
| Zhao, LN | 1 |
| Shi, Y | 1 |
| Wang, N | 1 |
| Wang, L | 2 |
| Han, ZG | 1 |
| She, S | 1 |
| Wu, X | 1 |
| Zheng, D | 1 |
| Pei, X | 1 |
| Sun, Y | 1 |
| Zhou, J | 1 |
| Nong, L | 1 |
| Guo, C | 1 |
| Lv, P | 1 |
| Song, Q | 1 |
| Zheng, C | 1 |
| Liang, W | 1 |
| Huang, S | 1 |
| Li, Q | 1 |
| Liu, Z | 2 |
| Li, Y | 1 |
| Zhang, Y | 3 |
| Kong, W | 1 |
| You, H | 1 |
| Xi, J | 1 |
| Campos, G | 1 |
| Schmidt-Heck, W | 1 |
| De Smedt, J | 1 |
| Widera, A | 1 |
| Ghallab, A | 1 |
| Pütter, L | 1 |
| González, D | 1 |
| Edlund, K | 1 |
| Cadenas, C | 1 |
| Marchan, R | 1 |
| Guthke, R | 1 |
| Verfaillie, C | 1 |
| Hetz, C | 1 |
| Sachinidis, A | 1 |
| Braeuning, A | 1 |
| Schwarz, M | 1 |
| Weiß, TS | 1 |
| Banhart, BK | 1 |
| Hoek, J | 1 |
| Vadigepalli, R | 1 |
| Willy, J | 1 |
| Stevens, JL | 1 |
| Hay, DC | 1 |
| Hengstler, JG | 1 |
| Godoy, P | 1 |
| Lin, YH | 1 |
| Zhang, S | 2 |
| Zhu, M | 1 |
| Lu, T | 1 |
| Chen, K | 1 |
| Wen, Z | 1 |
| Wang, S | 3 |
| Xiao, G | 1 |
| Luo, D | 1 |
| Jia, Y | 1 |
| MacConmara, M | 1 |
| Hoshida, Y | 3 |
| Singal, AG | 1 |
| Yopp, A | 1 |
| Zhu, H | 1 |
| Jung, YS | 1 |
| Stratton, SA | 1 |
| Lee, SH | 1 |
| Kim, MJ | 1 |
| Jun, S | 1 |
| Zhang, J | 1 |
| Zheng, B | 1 |
| Cervantes, CL | 1 |
| Cha, JH | 1 |
| Barton, MC | 1 |
| Park, JI | 1 |
| Kikuchi, A | 1 |
| Singh, S | 2 |
| Poddar, M | 2 |
| Nakao, T | 1 |
| Schmidt, HM | 1 |
| Gayden, JD | 1 |
| Sato, T | 1 |
| Arteel, GE | 1 |
| Monga, SP | 2 |
| Yakubu, OF | 1 |
| Metibemu, DS | 1 |
| Adelani, IB | 1 |
| Adesina, GO | 1 |
| Edokwe, CB | 1 |
| Oseha, OE | 1 |
| Adebayo, AH | 1 |
| Sun, M | 1 |
| Li, W | 2 |
| Liu, C | 2 |
| Jiang, Z | 1 |
| Gu, P | 1 |
| Wang, W | 1 |
| You, R | 1 |
| Ba, Q | 1 |
| Li, X | 3 |
| Wang, H | 3 |
| Sydor, S | 1 |
| Manka, P | 1 |
| Best, J | 1 |
| Jafoui, S | 1 |
| Sowa, JP | 1 |
| Zoubek, ME | 1 |
| Hernandez-Gea, V | 1 |
| Cubero, FJ | 1 |
| Kälsch, J | 1 |
| Vetter, D | 1 |
| Fiel, MI | 1 |
| Bian, CB | 1 |
| Nelson, LJ | 1 |
| Moshage, H | 1 |
| Faber, KN | 1 |
| Paul, A | 1 |
| Baba, HA | 1 |
| Gerken, G | 1 |
| Friedman, SL | 1 |
| Canbay, A | 1 |
| Bechmann, LP | 1 |
| Wu, Q | 1 |
| Chen, JX | 1 |
| Chen, Y | 5 |
| Cai, LL | 1 |
| Wang, XZ | 1 |
| Guo, WH | 1 |
| Zheng, JF | 1 |
| Dou, C | 1 |
| Tu, K | 1 |
| Zhang, H | 3 |
| Yaqoob, U | 1 |
| Wen, J | 1 |
| van Deursen, J | 1 |
| Sicard, D | 1 |
| Tschumperlin, D | 1 |
| Zou, H | 1 |
| Huang, WC | 1 |
| Urrutia, R | 1 |
| Shah, VH | 1 |
| Kang, N | 1 |
| Preziosi, M | 1 |
| Delire, B | 1 |
| Henriet, P | 1 |
| Lemoine, P | 1 |
| Leclercq, IA | 1 |
| Stärkel, P | 1 |
| D'Souza, AM | 1 |
| Jiang, Y | 1 |
| Cast, A | 1 |
| Valanejad, L | 1 |
| Wright, M | 1 |
| Lewis, K | 1 |
| Kumbaji, M | 1 |
| Shah, S | 1 |
| Smithrud, D | 1 |
| Karns, R | 1 |
| Shin, S | 1 |
| Timchenko, N | 1 |
| Romualdo, GR | 1 |
| Prata, GB | 1 |
| da Silva, TC | 1 |
| Fernandes, AAH | 1 |
| Moreno, FS | 1 |
| Cogliati, B | 1 |
| Barbisan, LF | 1 |
| Lee, C | 1 |
| Kim, M | 1 |
| Lee, JH | 1 |
| Oh, J | 1 |
| Shin, HH | 1 |
| Lee, SM | 1 |
| Scherer, PE | 1 |
| Kwon, HM | 1 |
| Choi, JH | 1 |
| Park, J | 1 |
| Iwako, H | 1 |
| Tashiro, H | 1 |
| Okimoto, S | 1 |
| Yamaguchi, M | 1 |
| Abe, T | 1 |
| Kuroda, S | 1 |
| Kobayashi, T | 1 |
| Ohdan, H | 1 |
| Zuo, L | 1 |
| Zhu, Y | 1 |
| Hu, L | 1 |
| Hu, Y | 1 |
| Pan, X | 1 |
| Li, K | 1 |
| Du, N | 1 |
| Huang, Y | 2 |
| Zhang, HE | 1 |
| Henderson, JM | 1 |
| Gorrell, MD | 1 |
| Seo, W | 1 |
| Gao, Y | 1 |
| He, Y | 1 |
| Sun, J | 1 |
| Xu, H | 1 |
| Feng, D | 1 |
| Park, SH | 1 |
| Cho, YE | 1 |
| Guillot, A | 1 |
| Ren, T | 1 |
| Wu, R | 1 |
| Kim, SJ | 1 |
| Hwang, S | 1 |
| Liangpunsakul, S | 1 |
| Niu, J | 1 |
| Gao, B | 1 |
| Sengupta, D | 1 |
| Chowdhury, KD | 1 |
| Sarkar, A | 1 |
| Paul, S | 1 |
| Sadhukhan, GC | 1 |
| Luo, M | 1 |
| Huang, SX | 1 |
| Kuang, ZP | 1 |
| Luo, XL | 1 |
| Li, YD | 1 |
| Wu, JN | 1 |
| Xie, YA | 1 |
| Xu, B | 1 |
| Li, SH | 1 |
| Gao, SB | 1 |
| Ding, LH | 1 |
| Yin, ZY | 1 |
| Lin, X | 1 |
| Feng, ZJ | 1 |
| Wang, XM | 1 |
| Jin, GH | 1 |
| Chappell, G | 1 |
| Kutanzi, K | 1 |
| Uehara, T | 2 |
| Tryndyak, V | 1 |
| Hong, HH | 1 |
| Hoenerhoff, M | 1 |
| Beland, FA | 1 |
| Rusyn, I | 2 |
| Pogribny, IP | 2 |
| Reiberger, T | 2 |
| Duyverman, AM | 1 |
| Huang, P | 2 |
| Samuel, R | 2 |
| Hiddingh, L | 1 |
| Roberge, S | 2 |
| Koppel, C | 1 |
| Lauwers, GY | 3 |
| Zhu, AX | 2 |
| Jain, RK | 2 |
| Duda, DG | 2 |
| Fuchs, BC | 1 |
| Fujii, T | 1 |
| Wei, L | 1 |
| Yamada, S | 1 |
| McGinn, CM | 1 |
| DePeralta, DK | 1 |
| Chen, X | 1 |
| Kuroda, T | 1 |
| Lanuti, M | 1 |
| Schmitt, AD | 1 |
| Gupta, S | 1 |
| Crenshaw, A | 1 |
| Onofrio, R | 1 |
| Taylor, B | 1 |
| Winckler, W | 1 |
| Bardeesy, N | 2 |
| Caravan, P | 1 |
| Golub, TR | 1 |
| Tanabe, KK | 1 |
| Li, F | 2 |
| Ma, N | 1 |
| Zhao, R | 1 |
| Wu, G | 1 |
| Qiao, Y | 1 |
| Han, D | 1 |
| Xu, Y | 1 |
| Xiang, Y | 1 |
| Yan, B | 1 |
| Jin, J | 1 |
| Lv, G | 1 |
| Xu, C | 1 |
| Gao, X | 1 |
| Luo, S | 1 |
| Abdel-Monem, AR | 1 |
| Kandil, ZA | 1 |
| Abdel-Naim, AB | 1 |
| Abdel-Sattar, E | 1 |
| Caviglia, JM | 1 |
| Schwabe, RF | 1 |
| Hung, TM | 1 |
| Yuan, RH | 1 |
| Huang, WP | 1 |
| Chen, YH | 1 |
| Lin, YC | 1 |
| Lin, CW | 1 |
| Lai, HS | 1 |
| Lee, PH | 1 |
| Ramjiawan, RR | 1 |
| Hato, T | 1 |
| Fan, C | 1 |
| Yang, J | 1 |
| Qiu, B | 1 |
| Liu, W | 1 |
| Xiao, J | 1 |
| Zhou, X | 1 |
| Xu, M | 1 |
| Hu, C | 1 |
| Xu, X | 1 |
| Lu, Y | 1 |
| Xue, S | 1 |
| Nie, L | 1 |
| Li, Z | 1 |
| Ji, F | 1 |
| Hui, L | 1 |
| Tao, W | 1 |
| Wei, B | 1 |
| Chung, SI | 1 |
| Moon, H | 1 |
| Kim, DY | 2 |
| Cho, KJ | 1 |
| Ju, HL | 1 |
| Ahn, SH | 1 |
| Han, KH | 1 |
| Ro, SW | 1 |
| Hyun, J | 1 |
| Kim, J | 1 |
| Rao, KM | 1 |
| Park, SY | 1 |
| Chung, I | 1 |
| Ha, CS | 1 |
| Kim, SW | 1 |
| Yun, YH | 1 |
| Jung, Y | 1 |
| Liu, CH | 1 |
| Chan, KM | 1 |
| Chiang, T | 1 |
| Liu, JY | 1 |
| Chern, GG | 1 |
| Hsu, FF | 1 |
| Wu, YH | 1 |
| Liu, YC | 1 |
| Tsuji, S | 1 |
| Ohbayashi, T | 1 |
| Yamakage, K | 1 |
| Oshimura, M | 1 |
| Tada, M | 1 |
| Magdaleno, F | 1 |
| Arriazu, E | 1 |
| Ruiz de Galarreta, M | 1 |
| Ge, X | 1 |
| Conde de la Rosa, L | 1 |
| Nieto, N | 1 |
| Polat, B | 1 |
| Halici, Z | 1 |
| Cadirci, E | 1 |
| Karakus, E | 1 |
| Bayir, Y | 1 |
| Albayrak, A | 1 |
| Unal, D | 1 |
| Matsuura, K | 1 |
| Sawai, H | 1 |
| Ikeo, K | 1 |
| Ogawa, S | 1 |
| Iio, E | 1 |
| Isogawa, M | 1 |
| Shimada, N | 1 |
| Komori, A | 1 |
| Toyoda, H | 1 |
| Kumada, T | 1 |
| Namisaki, T | 1 |
| Yoshiji, H | 1 |
| Sakamoto, N | 1 |
| Nakagawa, M | 1 |
| Asahina, Y | 1 |
| Kurosaki, M | 1 |
| Izumi, N | 1 |
| Enomoto, N | 1 |
| Kusakabe, A | 1 |
| Kajiwara, E | 1 |
| Itoh, Y | 1 |
| Ide, T | 1 |
| Tamori, A | 1 |
| Matsubara, M | 1 |
| Kawada, N | 1 |
| Shirabe, K | 1 |
| Tomita, E | 1 |
| Honda, M | 1 |
| Kaneko, S | 1 |
| Nishina, S | 1 |
| Suetsugu, A | 1 |
| Hiasa, Y | 1 |
| Watanabe, H | 2 |
| Genda, T | 1 |
| Sakaida, I | 2 |
| Nishiguchi, S | 1 |
| Takaguchi, K | 1 |
| Tanaka, E | 1 |
| Sugihara, J | 1 |
| Shimada, M | 1 |
| Kondo, Y | 1 |
| Kawai, Y | 1 |
| Kojima, K | 1 |
| Nagasaki, M | 1 |
| Tokunaga, K | 1 |
| Tanaka, Y | 1 |
| Ma, X | 1 |
| Xu, L | 1 |
| Chen, H | 1 |
| Ning, G | 1 |
| Sakai, T | 1 |
| Liu, L | 1 |
| Teng, X | 1 |
| Ishimaru, N | 1 |
| Mukai-Sakai, R | 1 |
| Tran, NH | 1 |
| Kim, SM | 1 |
| Sano, N | 1 |
| Hayashi, Y | 1 |
| Kaji, R | 1 |
| Fukui, K | 1 |
| Rivadeneira, DB | 1 |
| Mayhew, CN | 1 |
| Thangavel, C | 1 |
| Sotillo, E | 1 |
| Reed, CA | 1 |
| Graña, X | 1 |
| Knudsen, ES | 1 |
| ESCHENBRENNER, AB | 1 |
| MILLER, E | 1 |
| Yu, JH | 2 |
| Zhu, BM | 2 |
| Wickre, M | 1 |
| Riedlinger, G | 2 |
| Chen, W | 1 |
| Hosui, A | 1 |
| Robinson, GW | 1 |
| Hennighausen, L | 2 |
| Komatsu, Y | 1 |
| Waku, T | 1 |
| Iwasaki, N | 1 |
| Ono, W | 1 |
| Yamaguchi, C | 1 |
| Yanagisawa, J | 1 |
| Maeda, M | 1 |
| Takami, T | 1 |
| Terai, S | 1 |
| Kang, K | 1 |
| Abdel-Hamid, NM | 1 |
| Abdel-Ghany, MI | 1 |
| Nazmy, MH | 1 |
| Amgad, SW | 1 |
| Hussain, T | 2 |
| Siddiqui, HH | 2 |
| Fareed, S | 2 |
| Vijayakumar, M | 2 |
| Rao, CV | 2 |
| Chaung, SS | 1 |
| Lin, CC | 1 |
| Lin, J | 1 |
| Yu, KH | 1 |
| Hsu, YF | 1 |
| Yen, MH | 1 |
| ANDERVONT, HB | 1 |
| LEDUC, EH | 1 |
| WILSON, JW | 1 |
| DELLA PORTA, G | 1 |
| TERRACINI, B | 1 |
| SHUBIK, P | 1 |
| COLE, LJ | 2 |
| NOWELL, PC | 2 |
| KIPLINGER, GF | 1 |
| KENSLER, CJ | 1 |
| STOWELL, RE | 1 |
| LEE, CS | 1 |
| TSUBOI, KK | 1 |
| VILLASANA, A | 1 |
| Kato, I | 1 |
| Kawaguchi, H | 1 |
| Takasawa, K | 1 |
| Hibino, Y | 1 |
| Hiraga, K | 1 |
| Huang, X | 1 |
| Yu, C | 1 |
| Jin, C | 1 |
| Yang, C | 1 |
| Xie, R | 1 |
| Cao, D | 1 |
| Wang, F | 1 |
| McKeehan, WL | 1 |
| Seki, T | 1 |
| Morimura, S | 1 |
| Tabata, S | 1 |
| Tang, Y | 1 |
| Shigematsu, T | 1 |
| Kida, K | 1 |
| Frezza, EE | 1 |
| Gerunda, GE | 1 |
| Farinati, F | 1 |
| DeMaria, N | 1 |
| Galligioni, A | 1 |
| Plebani, F | 1 |
| Giacomin, A | 1 |
| Van Thiel, DH | 1 |
| Tsunematsu, S | 2 |
| Saito, H | 2 |
| Kagawa, T | 1 |
| Morizane, T | 2 |
| Hata, J | 1 |
| Nakamura, T | 1 |
| Ishii, H | 2 |
| Tsuchiya, M | 1 |
| Nomura, T | 1 |
| Katsuki, M | 1 |
| Fukuda, K | 1 |
| Kojiro, M | 1 |
| Chiu, JF | 1 |
| Sato, R | 1 |
| Hamasaki, K | 1 |
| Nakashima, M | 1 |
| Naito, S | 1 |
| Akiyama, Y | 1 |
| Ohtsuru, A | 1 |
| Hamanaka, Y | 1 |
| Hsu, CT | 1 |
| Ito, M | 1 |
| Sekine, I | 1 |
| Sawada, S | 1 |
| Murakami, K | 1 |
| Murata, J | 1 |
| Tsukada, K | 1 |
| Saiki, I | 1 |
| Yoda-Murakami, M | 1 |
| Taniguchi, M | 1 |
| Takahashi, K | 1 |
| Kawamata, S | 1 |
| Saito, K | 1 |
| Choi-Miura, NH | 1 |
| Tomita, M | 1 |
| Tanaka, F | 1 |
| Hori, N | 1 |
| Sato, K | 1 |
| Desai, HN | 1 |
| Scotto, JM | 1 |
| Stralin, HG | 1 |
| Lageron, A | 1 |
| Lemonnier, FJ | 1 |
| Takizawa, S | 1 |
| Naito, Y | 1 |
| Inoue, S | 1 |
| Kozuka, S | 1 |
| Sassa, R | 1 |
| Saliamon, LS | 2 |
| Ostretsova, IB | 3 |
| Senatorova, TA | 1 |
| Katsukura, Y | 1 |
| Abe, N | 1 |
| Watabe, N | 1 |
| Tsuchiya, T | 1 |
| Webb, TE | 2 |
| Potter, VR | 1 |
| Stanislawski-Birencwajg, M | 1 |
| Uriel, J | 1 |
| Grabar, P | 1 |
| Kwan, SW | 1 |
| Morris, HP | 1 |
| Ashmarin, IP | 1 |
| Lyzlova, SN | 1 |
| Pluzhnikova, GF | 1 |
| Vas'kina, LV | 1 |
| Warwick, GP | 1 |
| Reuber, MD | 1 |
| Sun, SC | 1 |
| Wei, RD | 1 |
| Schaeffer, BT | 1 |
| Hathway, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma[NCT01356628] | Phase 2 | 23 participants (Actual) | Interventional | 2011-05-25 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number and nature of adverse events as a measure of safety and tolerability. Safety analysis will be conducted on all patients who receive at least one dose of PD-0332991 during the study period or follow-up. An adverse event is any unfavorable and unintended sign, symptom, syndrome or illness that develops during the period of observation in the clinical study, including a new illness or condition, worsening of a concomitant illnesses or condition, effect of the study medication or combination of 2 or more factors. (NCT01356628)
Timeframe: From date of randomization through study completion, assessed up to 100 months
| Intervention | Adverse Events (Number) |
|---|---|
| PD-0332991 | 504 |
Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST Version 1.1), as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). The appearance of one or more new lesions is also considered progression. (NCT01356628)
Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
| Intervention | months (Mean) |
|---|---|
| PD-0332991 | 8 |
2 reviews available for carbon tetrachloride and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals.
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemica | 1974 |
1 trial available for carbon tetrachloride and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Tetrachloride; Carcinoma, Hepa | 2013 |
95 other studies available for carbon tetrachloride and Hepatocellular Carcinoma
| Article | Year |
|---|---|
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Liver Regeneration | 2022 |
A Titanium (IV)-Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical | 2021 |
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of
Topics: 3' Untranslated Regions; Angiopoietin-2; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2022 |
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fibrosis; Hepatic Stellate Cells; Humans; | 2022 |
Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro.
Topics: Aged; Aging; Animals; Canthaxanthin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Humans; Hydrog | 2022 |
Identification of circular RNA biomarkers for Pien Tze Huang treatment of CCl4‑induced liver fibrosis using RNA‑sequencing.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Case-Control Studies; Drugs, C | 2022 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
ADAMTS12 is a stromal modulator in chronic liver disease.
Topics: ADAMTS Proteins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatic Stellate Cells; Humans; Li | 2023 |
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis; | 2023 |
Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease M | 2019 |
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diet | 2019 |
The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.
Topics: Animals; Aristolochic Acids; Bile Duct Neoplasms; Carbon Tetrachloride; Carcinoma, Hepatocellular; C | 2020 |
PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Polarity; C | 2020 |
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury, Ch | 2020 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carbon Tetrachloride; Carcinogenesis; Car | 2021 |
Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Movement; Hepatic Stellate Cells; Liv | 2020 |
Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats.
Topics: Animals; Annona; Antineoplastic Agents, Phytogenic; Antioxidants; Carbon Tetrachloride; Carcinoma, H | 2020 |
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Drugs, Chinese Herbal; Hepatic | 2021 |
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Topics: Acetaminophen; Acute Lung Injury; Animals; Autophagy; Carbon Tetrachloride; Carcinoma, Hepatocellula | 2017 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
Topics: Animals; Benzoates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transdiffere | 2018 |
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer.
Topics: Animals; beta Catenin; Cadherins; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamin | 2018 |
Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Male; Mice; Mice, | 2018 |
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Topics: Animals; Benzenesulfonates; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell | 2018 |
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis.
Topics: Animals; Antithrombin III; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Fema | 2019 |
PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation.
Topics: Acid Sensing Ion Channels; Animals; Calcium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Caspas | 2019 |
Animal models for hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Disease Models, Animal; Gene Editing; Huma | 2019 |
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Topics: Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carbon Tetrachl | 2019 |
Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Berberine; Blotting, Western; Carbon T | 2014 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; CD11b Antigen; Cell Line, Tumor; Cell Move | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Coculture Techniques; Hep | 2014 |
A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl₄-induced injury on human hepatoma cell line (Huh7).
Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Fruit; Humans; Liver Neoplasms; M | 2015 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis.
Topics: Adult; Aged; Autophagy; Biomarkers; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Humans; | 2015 |
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Neoplasms; Liver Ne | 2015 |
p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Carbon Tetrachloride; Carcinoma, Hepatoc | 2015 |
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Escherichia | 2015 |
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.
Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; Ge | 2016 |
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Carcinoma, Hepatocellular; Choline; Chronic Disease; D | 2016 |
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyc | 2016 |
A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Biological Assay; Carbon Tetrachl | 2016 |
Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cartilage Oligomeric Matrix Protein; Hepat | 2016 |
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Fibrosis; Humans; Inflammation; | 2017 |
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Topics: Age Factors; Aged; alpha-Fetoproteins; Animals; Antiviral Agents; Carbon Tetrachloride; Carcinoma, H | 2017 |
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati | 2009 |
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; | 2010 |
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell | 2010 |
Liver necrosis and the induction of carbon tetrachloride hepatomas in strain A mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Diseases; Liver Neoplasms; Mi | 1946 |
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cyclin-Dependen | 2010 |
Global analysis of DNA methylation in early-stage liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chromosomes, Mammalian; Computational Biol | 2012 |
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carcinoma, | 2012 |
The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carbon Tetrachloride; Carc | 2012 |
Chemopreventive evaluation of Tephrosia purpurea against N-nitrosodiethylamine-induced hepatocarcinogenesis in Wistar rats.
Topics: alpha-Fetoproteins; Animals; Anticarcinogenic Agents; Carbon Tetrachloride; Carcinoembryonic Antigen | 2012 |
Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Ca | 2012 |
The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Ch | 2003 |
Induction of hepatomas in strain C3H mice with 4-o-tolyazoo-toluidine and carbon tetrachloride.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Coloring A | 1958 |
Transplantation of carbon tetrachloride-induced hepatomas in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Neoplasms, Experime | 1959 |
Induction with carbon tetrachloride of liver-cell carcinomas in hamsters.
Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental | 1961 |
Accelerated induction of hepatomas in fast neutron irradiated mice injected with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular; Fast Neutr | 1962 |
Failure of phenoxybenzamine to prevent formation of hepatomas after chronic carbon tetrachloride administration.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular; Liver Neoplasms; Ph | 1963 |
ACCELERATED INDUCTION OF HEPATOMAS IN FAST NEUTRON-IRRADIATED MICE INJECTED WITH CARBON TETRACHLORIDE.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fast Neutrons; Gastrointestinal Neoplasms; | 1964 |
Histochemical and microchemical changes in experimental cirrhosis and hepatoma formation in mice by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Cirrhosis, Experime | 1951 |
The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4.
Topics: Animals; Base Sequence; Binding Sites; Carbon Tetrachloride; Carcinoma, Hepatocellular; Carrier Prot | 2006 |
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Fibroblas | 2006 |
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu.
Topics: Acetic Acid; Alcoholic Beverages; Animals; Antioxidants; Carbon Tetrachloride; Carcinoma, Hepatocell | 2008 |
CCL4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Copper; Disease Models, Animal; Estradiol; | 1994 |
Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Death; DNA, Neoplasm; | 1994 |
Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Death; Chromatin; DNA; Isc | 1993 |
Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; Ge | 1997 |
The sympathetic nervous system promotes carbon tetrachloride-induced liver cirrhosis in rats by suppressing apoptosis and enhancing the growth kinetics of regenerating hepatocytes.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Division; Hepatocytes; Imm | 2001 |
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; DNA Primers; Extracellular Matrix; Extrace | 2001 |
Change in expression of GBP28/adiponectin in carbon tetrachloride-administrated mouse liver.
Topics: Adiponectin; Animals; Antisense Elements (Genetics); Carbon Tetrachloride; Carcinoma, Hepatocellular | 2001 |
Identification of differentially expressed genes in rat hepatoma cell lines using subtraction and microarray.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Differentiation; Gene Expression; Gen | 2002 |
Immunological aspects of hepatocellular carcinoma in the guinea-pig.
Topics: Animals; Antigens, Neoplasm; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Migration Inhibit | 1976 |
Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinoma, Hepatocellular | 1975 |
Preparative action of carbon tetrachloride in liver tumorigenesis by a single application of N-butylnitrosourea in male ICR/JCL strain mice.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism; | 1975 |
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes; | 1976 |
[Several patterns in the disdifferentiated changes in the activity of enzymes during blastomogenesis].
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Neoplasms, Experime | 1977 |
Distribution pattern of liver matrix proteins, fibronectin and type I collagen, in DAB-induced hepatoma of rat.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Collagen; Female; Fibronectins; Histocytoc | 1985 |
Polyribosomes in rat tissues. IV. On the abnormal dimer peak in hepatomas.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin; In Vitro Te | 1966 |
Association of embryonic antigens with experimentally induced hepatic lesions in the rat.
Topics: Animals; Antigens; Cadmium; Carbon Tetrachloride; Carcinoma, Hepatocellular; Embryo, Mammalian; Fema | 1967 |
Diversity and nature of ribosomal pools in hepatoma 7800 and host liver.
Topics: Animals; Azaguanine; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin; | 1968 |
[Analysis of tumor transformation in tissues. II. Biochemical dedifferentiation in the process of cancerogenesis (changes in creatine kinase and alkaline phosphatase as an example)].
Topics: Alkaline Phosphatase; Animals; Anura; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transfor | 1970 |
The covalent binding of metabolites of tritiated 2-methyl-4-dimethylamino-azobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats.
Topics: Aniline Compounds; Animals; Azo Compounds; Carbon Tetrachloride; Carcinoma, Hepatocellular; Hepatect | 1967 |
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1970 |
[Changes in creatine kinase activity in the presence of tumor processes in the liver].
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Creatine Kinase; Liver Neoplasms; Male; Mi | 1970 |
The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Ethanol; Fatty Li | 1971 |