carbon tetrachloride has been researched along with Disease Models, Animal in 878 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of the present study was to evaluate the antioxidant, cytotoxic, thrombolytic, and antidiarrheal activities of carbon tetrachloride (CCl4) fraction of leaves of A." | 7.96 | Evaluation of carbon tetrachloride fraction of Actinodaphne angustifolia Nees (Lauraceae) leaf extract for antioxidant, cytotoxic, thrombolytic and antidiarrheal properties. ( Alam, T; Azam, S; Islam, MA; Jakaria, M; Kamal, AM; Khan, TA; Uddin, MN; Zaman, RU, 2020) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 7.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| "Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury." | 7.83 | Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. ( Barta, I; Chow, LN; Crawford, J; Gusti, V; Hughes, MR; Lecour, S; Lo, B; Manisali, I; McNagny, KM; Ng, BY; Schreiner, P; Scott, RW; Simonson, E; Underhill, TM; Webb, M, 2016) |
| "Launaea procumbens methanol extract (LPME) was evaluated against carbon tetrachloride (CCl4)-induced pancreatic oxidative damage and hyperglycemia in rats." | 7.81 | Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study. ( Ahmed, M; Khan, MR; Khan, RA; Sahreen, S; Shah, NA, 2015) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 7.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| " In this study, we investigated whether 3-genes iPSC transplantation is capable of rescuing carbon tetrachloride (CCl(4))-induced fulminant hepatic failure and hepatic encephalopathy in mice." | 7.78 | Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. ( Chang, HM; Chang, YL; Chen, HL; Chen, LK; Chen, SY; Chen, YJ; Chiang, CH; Chien, Y; Hsieh, JH; Huo, TI; Jeng, SY; Lai, YH; Li, HY; Liao, YW; Peng, CH, 2012) |
| " Forty Sprague-Dawley rats with carbon tetrachloride-induced liver cirrhosis and 20 control rats were intraperitoneally administered a single dose of DEG, and randomly killed 1, 2, 5 or 8 days following exposure." | 7.77 | Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase. ( , 2011) |
| "The aim of this study was to investigate the pharmacokinetic changes of verapamil and its major metabolite, norverapamil, after oral administration of verapamil (10 mg/kg) in rabbits with slight, moderate and severe hepatic failure induced by carbon tetrachloride." | 7.73 | Pharmacokinetics of verapamil and its major metabolite, norverapamil from oral administration of verapamil in rabbits with hepatic failure induced by carbon tetrachloride. ( Burm, JP; Choi, JS, 2005) |
| "The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1 ml/kg) of carbon tetrachloride." | 7.70 | Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat. ( Díaz-Zagoya, JC; Juárez-Oropeza, MA; Mascher, D; Miranda-Zamora, R; Paredes-Carbajal, MC; Torres-Durán, PV, 1998) |
| "To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure." | 7.70 | [Effects of calcitriol and alfacalcidol on an osteoporosis model in rats with hepatic failure]. ( Ishibashi, Y; Kojima, E; Kuriyama, K; Kusajima, H; Momo, K; Tachiiri, T; Yamanishi, A, 1999) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 5.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 5.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "In rats with acute hepatic failure, the hepatic P-glycoprotein concentration increased 1." | 5.31 | Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. ( Huang, ZH; Murakami, T; Nagai, J; Okochi, A; Takano, M; Yumoyo, R, 2001) |
| "The relationships between the pharmacokinetic behaviour of glycyrrhizin and its restorative effect for hepatic function were investigated in patients with chronic hepatitis and in rats chronically treated with carbon tetrachloride (CCl4-treated rats)." | 5.08 | The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats. ( Aikawa, T; Iga, T; Kotaki, H; Sawada, Y; Tanaka, N; Yamamura, Y, 1997) |
| " In carbon tetrachloride-induced micronodular cirrhosis, portal sinusoidal flow, which reaches liver parenchyma, is high, and this is more pronounced in the presence of ascites." | 4.81 | Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow. ( Reichen, J; Sägesser, H; Van de Casteele, M; Zimmermann, H, 2001) |
| "Here, we examine the impact of housing temperature on steatosis, hepatocellular damage, hepatic inflammation, and fibrosis in NASH diet, methionine and choline deficient diet, and western diet + carbon tetrachloride experimental models of NAFLD in C57BL/6 mice." | 4.31 | Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. ( Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S, 2023) |
| "The effects of the miR-125a/VDR axis on hepatic fibrosis and its underlying mechanisms were investigated in a carbon tetrachloride (CCl4)-induced mouse model and patients with liver cirrhosis by immunohistochemistry, real-time PCR, Western blotting, and luciferase reporter assay." | 4.02 | MicroRNA-125a/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis. ( Fan, Z; He, W; Liu, L; Ni, W; Wang, X; Zhao, L, 2021) |
| " The objective of the present study was to evaluate the antioxidant, cytotoxic, thrombolytic, and antidiarrheal activities of carbon tetrachloride (CCl4) fraction of leaves of A." | 3.96 | Evaluation of carbon tetrachloride fraction of Actinodaphne angustifolia Nees (Lauraceae) leaf extract for antioxidant, cytotoxic, thrombolytic and antidiarrheal properties. ( Alam, T; Azam, S; Islam, MA; Jakaria, M; Kamal, AM; Khan, TA; Uddin, MN; Zaman, RU, 2020) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 3.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| "Canine BM cells were harvested and cultured, and the resultant BMSCs were returned to carbon tetrachloride (CCl4)-induced liver cirrhosis model canines via either a peripheral vein (Vein group) or hepatic artery (Artery group)." | 3.91 | Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model. ( Aibe, Y; Fujisawa, K; Matsuda, T; Matsumoto, T; Nishimura, T; Sakaida, I; Sasaki, R; Takami, T; Tani, K; Taura, Y; Yamamoto, N, 2019) |
| "The aim of the study was to examine whether a rat model of liver cirrhosis induced by carbon tetrachloride (CCl4) is a suitable model of muscle wasting and alterations in amino acid metabolism in cirrhotic humans." | 3.88 | Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis. ( Holeček, M; Vodeničarovová, M, 2018) |
| "Liver fibrosis/cirrhosis was induced in wild type and TGFβ overproducing transgenic mice by carbon tetrachloride and thioacetamide administration." | 3.85 | Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models. ( Bugyik, E; Dezső, K; Mózes, M; Nagy, P; Paku, S; Rókusz, A; Szücs, A; Veres, D, 2017) |
| "The effect of systemic treatment with adipose tissue-derived MSCs, pre-differentiated into hepatocytic cells, was investigated in a rat model of liver cirrhosis induced by chronic inhalation of carbon tetrachloride." | 3.85 | Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells. ( Brückner, S; Christ, B; Hempel, M; Roderfeld, M; Roeb, E; Schwill, F; Thonig, A; Zipprich, A, 2017) |
| "Modulation of chemokine CXCL12 and its receptor CXCR4 has been implicated in attenuation of bleomycin (BLM)-induced pulmonary fibrosis and carbon tetrachloride (CCl4)-induced hepatic injury." | 3.83 | Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. ( Barta, I; Chow, LN; Crawford, J; Gusti, V; Hughes, MR; Lecour, S; Lo, B; Manisali, I; McNagny, KM; Ng, BY; Schreiner, P; Scott, RW; Simonson, E; Underhill, TM; Webb, M, 2016) |
| "Curcumin significantly attenuated inflammation and fibrosis, as revealed by histological and biochemical analysis." | 3.83 | Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1. ( Chen, J; Huang, R; Liu, Y; Pan, Z; Sun, Z; Wang, G; Wang, J; Wu, C; Wu, H; Xia, J; Xiong, Y; Yan, X; Zhang, Z, 2016) |
| "Launaea procumbens methanol extract (LPME) was evaluated against carbon tetrachloride (CCl4)-induced pancreatic oxidative damage and hyperglycemia in rats." | 3.81 | Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study. ( Ahmed, M; Khan, MR; Khan, RA; Sahreen, S; Shah, NA, 2015) |
| " U-MSCs and DHLCs were injected 48 h after induced fulminant hepatitis (intraperitoneal injection of carbon tetrachloride) in SCID/BALB-c mice." | 3.81 | Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis. ( Boin, I; da Silva Santos Duarte, A; Escanhoela, C; Kharmandayan, P; Latuf-Filho, P; Malheiros Luzo, ÂC; Manzini, BM; Olalla Saad, ST; Ramos, AL; Sankaramanivel, S, 2015) |
| "Sorafenib--a broad kinase inhibitor--is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC." | 3.80 | Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. ( Chen, Y; Duda, DG; Duyverman, AM; Hiddingh, L; Huang, P; Huang, Y; Jain, RK; Koppel, C; Lauwers, GY; Reiberger, T; Roberge, S; Samuel, R; Zhu, AX, 2014) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 3.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| "This study demonstrates that hesperidin prevents experimental necrosis and fibrosis." | 3.80 | Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor. ( Muriel, P; Pérez-Vargas, JE; Segovia, J; Shibayama, M; Tsutsumi, V; Zarco, N, 2014) |
| " C57BL/6N mice were fed a high-fat diet (HFD) to develop obesity and were either administered carbon tetrachloride (CCl4 ) eight times (0." | 3.79 | A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice. ( Ishikawa, F; Kado, S; Kano, M; Kobayashi, T; Kubota, N; Masuoka, N; Miyazaki, K; Nagata, Y, 2013) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| " In the present experiments we investigated the efficiency of a primary hepatocyte mitogen 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOB) on two different liver cirrhosis/fibrosis models in mice induced by chronic administration of CCl(4) and thioacetamide respectively." | 3.78 | 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver. ( Bugyik, E; Dezso, K; Nagy, P; Paku, S; Szurián, K; Turányi, E, 2012) |
| " In this study, we investigated whether 3-genes iPSC transplantation is capable of rescuing carbon tetrachloride (CCl(4))-induced fulminant hepatic failure and hepatic encephalopathy in mice." | 3.78 | Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. ( Chang, HM; Chang, YL; Chen, HL; Chen, LK; Chen, SY; Chen, YJ; Chiang, CH; Chien, Y; Hsieh, JH; Huo, TI; Jeng, SY; Lai, YH; Li, HY; Liao, YW; Peng, CH, 2012) |
| "Droxidopa might be an effective therapeutic agent for hemodynamic and renal alterations of liver cirrhosis and should be tested in cirrhosis patients." | 3.78 | Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. ( Augustin, S; Brull, A; Coll, M; Esteban, R; Ezkurdia, N; Genescà, J; Guardia, J; Martell, M; Raurell, I; Rodriguez, S, 2012) |
| " Forty Sprague-Dawley rats with carbon tetrachloride-induced liver cirrhosis and 20 control rats were intraperitoneally administered a single dose of DEG, and randomly killed 1, 2, 5 or 8 days following exposure." | 3.77 | Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase. ( , 2011) |
| " Female rats with carbon tetrachloride (CCl₄-induced liver cirrhosis were injected CM-DiI-labeled monocytes, CD14⁻ cells (1 x 10⁷ cells/rat) or saline via the portal vein." | 3.76 | The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis. ( Cao, Y; Cheng, X; Cui, L; Fan, D; Han, Y; Han, Z; Liang, J; Qiao, L; Shi, Y; Wang, J; Yan, L; Zhou, X, 2010) |
| "Human MSCs labeled with FDA-approved SPIO particles (Feridex) were transplanted via the mesenteric vein into rabbits (n = 16) with carbon tetrachloride-induced hepatic failure." | 3.76 | MRI of magnetically labeled mesenchymal stem cells in hepatic failure model. ( Choi, SH; Chung, SY; Kim, HC; Kim, HS; Lee, JM; Moon, WK; Son, KR, 2010) |
| " This study determined the role of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase deficiency in the development of hepatocellular necrosis, inflammation, and apoptosis in relation to fibrosis produced by chronic carbon tetrachloride (CCl(4)) administration." | 3.75 | Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. ( Aram, G; Liu, X; Mezey, E; Potter, JJ; Torbenson, MS; Wang, L, 2009) |
| "We investigated the effect of human umbilical mesenchymal stem cells (HUMSCs) from Wharton's jelly on carbon tetrachloride (CCl4)-induced liver fibrosis in rats." | 3.75 | The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. ( Chen, TH; Chen, YM; Fu, TW; Fu, YS; Hung, SC; Ko, TL; Shih, YH; Tsai, PC, 2009) |
| "The liver injury in the model rat was induced by alpha-naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl(4) ) respectively, and the effects of Yinchenhao Decoction (, YCHD), a proved effective Chinese medical formula for treating the dampness-heat jaundice syndrome in clinic, on the two liver injury models were evaluated by analyzing the serum level of alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), malondialchehyche (MDA), total bilirubin (T-BIL), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) as well as the ratio of liver weight to body weight." | 3.75 | Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride. ( Cao, HX; Jiang, XG; Liu, L; Lu, HT; Sun, H; Sun, WJ; Wang, P; Wang, XJ; Wu, ZM; Zhang, GM; Zhou, J, 2009) |
| "Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time." | 3.75 | Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009) |
| " plantarum strains were administered in ornithine transcarbamoylase-deficient Sparse-fur mice, a model of constitutive hyperammonemia, in a carbon tetrachloride rat model of chronic liver insufficiency and in a thioacetamide-induced acute liver failure mice model." | 3.74 | Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. ( Demetter, P; Devière, J; Goffin, P; Gustot, T; Hols, P; Moreno, C; Nicaise, C; Prozzi, D; Quertinmont, E; Suain, V; Viaene, E, 2008) |
| " In our present study, an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) method has been established and validated for simultaneous quantitation of 22 BAs and a metabonomic study was performed based on the chemometric analysis of the serum samples from carbon tetrachloride (CCl4)- and alpha-naphthylisothiocyanate (ANIT)-induced liver failure rats." | 3.74 | Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. ( He, Y; Hu, Z; Li, W; Wang, C; Wang, Z; Xiong, A; Yang, L, 2008) |
| " Acute carbon tetrachloride (CCl(4)) toxicity was similar in wild-type (WT), PAR-1(-/-), and PAR-1(+/-) mice as judged by aminotransferase levels, area of liver necrosis, and liver peroxidation measured by Fourier-transformed infrared spectroscopy." | 3.74 | Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis. ( Bioulac-Sage, P; Costet, P; Cubel, G; Deleris, G; Dugot-Senant, N; Gillibert-Duplantier, J; Haurie, V; Petibois, C; Rosenbaum, J; Rullier, A; Taras, D, 2008) |
| "The aim of this study was to investigate the pharmacokinetic changes of verapamil and its major metabolite, norverapamil, after oral administration of verapamil (10 mg/kg) in rabbits with slight, moderate and severe hepatic failure induced by carbon tetrachloride." | 3.73 | Pharmacokinetics of verapamil and its major metabolite, norverapamil from oral administration of verapamil in rabbits with hepatic failure induced by carbon tetrachloride. ( Burm, JP; Choi, JS, 2005) |
| "Dual-energy CT at 120 kVp and 90 kVp was performed in 16 rabbits of experimental groups that were induced to various degrees of fatty liver by feeding carbon tetrachloride (CCl4)." | 3.72 | Quantitative diagnosis of fatty liver with dual-energy CT. An experimental study in rabbits. ( Gao, Z; Li, L; Wang, B; Zou, Q, 2003) |
| "In an effort to develop a reproducible model of liver cirrhosis and esophageal varices, we administered phenobarbital (PhB) and carbon tetrachloride (CCl4) in 32 rats that had previously undergone complete devascularization of the left renal vein (DLRV)." | 3.71 | A rat model of liver cirrhosis and esophageal varices. ( Alatsakis, MB; Ballas, KD; Sakadamis, AK; Tzioufa-Asimakopoulou, V, 2001) |
| "The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1 ml/kg) of carbon tetrachloride." | 3.70 | Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat. ( Díaz-Zagoya, JC; Juárez-Oropeza, MA; Mascher, D; Miranda-Zamora, R; Paredes-Carbajal, MC; Torres-Durán, PV, 1998) |
| " However, hepatic HGF levels were decreased despite an increased number of mitotic hepatocytes and increased or unchanged plasma HGF levels in rats given phenobarbital and in rats after dimethylnitrosamine intoxication, which can induce hepatic necrosis after apoptosis of hepatic stellate cells." | 3.70 | Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration. ( Fujiwara, K; Ogata, I; Tomiya, T, 1998) |
| "To predict the potential utility of calcitriol in human osteoporosis with hepatic dysfunction, we examined the effects of calcitriol and alfacalcidol in ovariectomized (OVX) aged-rats with CCl4-induced hepatic failure." | 3.70 | [Effects of calcitriol and alfacalcidol on an osteoporosis model in rats with hepatic failure]. ( Ishibashi, Y; Kojima, E; Kuriyama, K; Kusajima, H; Momo, K; Tachiiri, T; Yamanishi, A, 1999) |
| " In this study, we describe a rat model of fatigue assessment using a swim tank, and we used this model to document the degree of fatigue in rat models of cholestasis caused by bile duct resection (BDR) and of hepatitis caused by carbon tetrachloride (CCl4) administration." | 3.69 | Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. ( Maric, M; Swain, MG, 1997) |
| "We sought to develop a rodent model of spontaneous bacterial peritonitis and report here the preliminary results of carbon tetrachloride-induced cirrhosis in which ascites and bacterial peritonitis predictably develop." | 3.68 | A rodent model of cirrhosis, ascites, and bacterial peritonitis. ( Kanel, G; Mellencamp, MA; Runyon, BA; Sugano, S, 1991) |
| "In the context of basic research in liver fibrosis and cirrhosis, it is essential to keep in mind that the capacity of the organ to recover spontaneously might be a significant limitation to long-term studies that use experimental models of liver cirrhosis." | 2.82 | Liver cirrhosis: An overview of experimental models in rodents. ( Dias, ML; Dos Santos Goldenberg, RC; Faccioli, LAP; Paranhos, BA, 2022) |
| "And 47 medium chronic hepatitis B viral fibrosis patients were studied." | 2.70 | Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis. ( Cai, WM; Liu, RH; Weng, HL, 2001) |
| "Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia." | 2.66 | Rodent Models of Nonalcoholic Fatty Liver Disease. ( Gao, L; Xu, J; Zhong, F; Zhou, X, 2020) |
| "To model liver fibrosis in mice is important as mechanisms not only of fibrogenesis, but also of fibrolysis, need to be clearly defined." | 2.44 | Mouse models of liver fibrosis. ( Herkel, J; Lohse, AW; Weiler-Normann, C, 2007) |
| " Rodent models of D-GalN-induced fibrosis are not recommended due to the long incubation period and weak toxic effect." | 1.91 | Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity. ( Bogunia, E; Czekaj, P; Grajoszek, A; Hermyt, M; Kolanko, E; Król, M; Limanówka, Ł; Michalik, M; Pająk, J; Prusek, A; Sikora, B; Skubis-Sikora, A, 2023) |
| "Canagliflozin (CANA) is a sodium-glucose cotransporter 2 inhibitor that was recently approved for treating diabetes." | 1.62 | Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase. ( Ding, Y; Dong, R; Meng, S; Wang, H; Wang, S; Yin, L, 2021) |
| " However, the pharmaceutical application of AA is limited by low oral bioavailability and poor targeting efficiency." | 1.62 | Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis. ( Pan, JC; Tu, LL; Yin, LN; Zhang, Y; Zhang, YW; Zheng, GL, 2021) |
| " Groups D, E, and F were intragastrically dosed with ZQRGD." | 1.62 | Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis. ( Che, JY; Chen, TT; He, J; He, Y; Shao, M; Shi, LP; Wang, J; Xie, T; Yuan, Z; Zhou, M, 2021) |
| "Liver fibrosis is a major medical problem with high mortality and morbidity rates where the formation of regenerative nodules and cirrhosis leads to loss of liver function and may result in the development of hepatocellular carcinoma." | 1.62 | Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis. ( Abo-Elmatty, DM; El-Demerdash, RS; Elminshawy, HH; Khalil, MR; Mehanna, ET; Mesbah, NM, 2021) |
| "Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury." | 1.62 | The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. ( Asaryan, A; Beaven, SW; Borawski, J; Cantor, RM; Carbone, W; Civelek, M; Clerkin, K; French, S; Fuqua, BK; Haroutunian, SG; Hui, ST; Knehr, J; Loureiro, J; Lusis, AJ; Magyar, C; Mehrabian, M; Pan, C; Parks, BW; Renaud, N; Roma, G; Tuominen, I; Ukomadu, C; Wroblewski, K, 2021) |
| "Liver fibrosis is a necessary stage in the development of chronic liver diseases to liver cirrhosis." | 1.62 | PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis. ( Cheng, P; Guo, C; Wu, J; Yu, Q, 2021) |
| "Hepatic injury progression to liver cirrhosis and cancer is a serious health issue across the world." | 1.62 | Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio. ( Ijaz, B; Koloko, BL; Malik, A; Rehman, S; Shahid, AA; Tariq, S, 2021) |
| "Liver fibrosis is the result of an excessive accumulation of extracellular matrix that develops when inflammation and chronic injury form scar tissue in the liver." | 1.62 | Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice. ( A M Alameen, A; Alzahrani, B; Tantawy, A, 2021) |
| "Liver fibrosis was attenuated in mice with Tgr5 depletion." | 1.62 | Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis. ( Bian, H; Gao, X; Huang, F; Jia, W; Jiang, R; Liu, P; Liu, Z; Qiu, J; Rajani, C; Sun, B; Wang, X; Wu, Y; Xie, G; Zhang, X; Zhao, A; Zhao, S; Zheng, X, 2021) |
| "However, its roles in liver fibrosis remain to be determined." | 1.62 | Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis. ( Chen, J; Hu, R; Li, J; Sun, J; Xing, X; Zhou, Q; Zhu, Z, 2021) |
| "Liver fibrosis is a common consequence of chronic liver diseases involved with the activation of hepatic stellate cells (HSCs) and endoplasmic reticulum (ER) stress." | 1.62 | Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells. ( Li, R; Liao, X; Tian, T; Yang, Q; Yu, L; Zhan, W, 2021) |
| "The main etiologies of liver fibrosis include nonalcoholic fatty liver disease (NAFLD), chronic viral hepatitis, as well as alcoholic and cholestatic liver disease." | 1.62 | Mouse Models of Liver Fibrosis. ( Ravichandra, A; Schwabe, RF, 2021) |
| "Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression." | 1.62 | Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells. ( Cheong, LY; Hoo, RLC; Lam, KSL; Li, J; Shu, L; Song, E; Wang, C; Wu, X; Xu, A; Ye, D; Zhang, Z; Zong, J, 2021) |
| "Mice chronic liver fibrosis models were established and divided into the olive-induced control group, CCL4-induced control group, olive-induced TIM-4 interference group and CCL4-induced TIM-4 interference group." | 1.56 | TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway. ( Chen, G; Deng, M; Gong, J; Wang, J; Wu, H; Yuan, F, 2020) |
| "Liver fibrosis was induced in mice using CCl4, and the differential expressions of several fibrosis-related long noncoding RNAs were detected in liver tissues." | 1.56 | Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. ( Chen, S; Luo, H; Ma, N; Tang, Y; Yu, F, 2020) |
| "Agn prevents liver fibrosis through its attenuation of HSC activation and division through the suppression of NF-κB in in vitro and animal models." | 1.56 | Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling. ( Ding, L; Jin, W; Sheng, X; Wu, J; Xia, Z; Xu, Y; Zheng, J, 2020) |
| "HGTLF could significantly improve liver fibrosis in mice." | 1.56 | Huagan tongluo Fang improves liver fibrosis via down-regulating miR-184 and up-regulating FOXO1 to inhibit Th17 cell differentiation. ( Cheng, Z; Geng, J; Hu, D; Huang, A; Qiu, Y; Tian, Y; Xuan, J, 2020) |
| "Liver fibrosis is a common part of the pathological development of many chronic liver diseases." | 1.56 | Camellia oil (Camellia oleifera Abel.) attenuates CCl ( Cao, Z; Du, H; Fang, Y; Fu, J; Kuang, T; Lei, X; Li, C; Liu, G; Liu, Q; Liu, Z; Qian, K; Xiao, Z; Xu, X; Zhang, J, 2020) |
| "Ursolic acid (UA) is a traditional Chinese medicine with anti-fibrotic effects, but the molecular mechanism underlying these effects is still unclear." | 1.56 | Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. ( Huang, C; Liu, C; Luo, F; Luo, Q; Wan, S; Zhu, X, 2020) |
| "The current research on the treatment of liver fibrosis mainly focuses on the activation of hepatic stellate cell, in addition to protecting liver cells." | 1.56 | Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice. ( Bai, J; Bi, Z; Li, H; Li, X; Ma, B; Ma, X; Ning, W; Shao, S; Wei, Y; Xie, C; Yang, C; Zhang, L; Zhang, R; Zhang, S; Zhou, H, 2020) |
| "Liver fibrosis will develop into liver cirrhosis unless the damaging factors are removed." | 1.56 | Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis. ( Guan, W; Lai, J; Lu, H; Sun, Y; Wu, X; Zhang, S, 2020) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 1.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects." | 1.51 | Praziquantel ameliorates CCl ( Kong, D; Liu, J; Liu, X; Lu, Z; Qiu, J; Wang, Y; Xie, Y; Zhang, R; Zhou, C, 2019) |
| "Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease." | 1.51 | New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019) |
| "Furthermore, AZGP1 alleviated NAFLD by blocking TNF-α-mediated inflammation and intracellular lipid deposition, promoting proliferation, and inhibiting apoptosis in LO2 cells." | 1.51 | Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. ( Li, ZH; Liu, T; Luo, SZ; Luo, X; Wu, JC; Xu, MY, 2019) |
| "However, the role of ferroptosis in liver fibrosis remains poorly understood." | 1.51 | P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. ( Chen, A; Jia, Y; Li, M; Shao, J; Wang, F; Wang, L; Zhang, F; Zhang, Z; Zheng, S, 2019) |
| "Liver cirrhosis is the end stage of chronic liver disease, and the only radical treatment for decompensated liver cirrhosis is still liver transplantation." | 1.51 | Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells. ( Sakaida, I; Takami, T; Tani, K; Taura, Y, 2019) |
| "To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal model." | 1.51 | Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex. ( Bannerjee, S; Bhattacharjee, P; Biswas, S; Harwansh, RK; Mukherjee, PK, 2019) |
| "Results indicate that the treatment of BM-MSCs in combination with silymarin had a better hepatoprotective and antimutagenic effect and represents a novel strategy for the treatment of hepatotoxicity." | 1.51 | Human bone marrow-derived mesenchymal stromal cells in combination with silymarin regulate hepatocyte growth factor expression and genotoxicity in carbon tetrachloride induced hepatotoxicity in Wistar rats. ( Aithal, AP; Bairy, LK; Rao, MK; Seetharam, RN, 2019) |
| "In the BDL model, liver fibrosis and Kuppfer cell numbers were increased in IL-1Ra KO mice compared to wild type mice and wild type mice treated with IL-1Ra." | 1.51 | Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner. ( Balaphas, A; Buhler, LH; Clément, S; Lacotte, S; Meier, RPH; Meyer, J; Montanari, E; Morel, P; Muller, YD; Negro, F; Toso, C, 2019) |
| "MATERIAL AND METHODS A liver fibrosis mouse model induced by carbon tetrachloride (CCl4) intervention was employed in this study." | 1.51 | Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells. ( Cao, S; Deng, Z; Ge, S; Kong, F; Pan, Z; Zhang, S, 2019) |
| "In the animal model of liver fibrosis, all doses of volatile oil of CG significantly reduced the serum levels of AST, ALT, MDA, Hyp, γ-GT, LDH, ALP, and Alb." | 1.51 | Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats. ( Han, C; Qin, DM; Wang, XB; Xu, J; Zou, N, 2019) |
| "In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatectomy (pHx)-induced liver regeneration." | 1.51 | Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers. ( Barnhoorn, MC; Coenraad, MJ; de Jonge-Muller, ESM; Hawinkels, LJAC; Molendijk, I; van der Helm, D; van Hoek, B; Verspaget, HW, 2019) |
| "Ketoconazole is a first orally available anti-fungal drug which has been reported as a potent inhibitor of human cytochrome P-450." | 1.51 | Hepatoprotective effect of ketoconazole in chronic liver injury model. ( Ahmed, M; Akhtar, U; Ali, G; Shehzad, U; Tayyeb, A, 2019) |
| "Here we established murine model of liver fibrosis and found that oroxylin A (40 mg/kg) could ameliorate angiogenesis in liver fibrosis may related to hypoxia inducible factor 1α (HIF-1α)." | 1.48 | Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. ( Bian, M; Chen, A; Chen, X; Guo, Q; Jin, H; Shao, J; Yang, X; Zhang, C; Zhang, F; Zhao, S; Zheng, S, 2018) |
| "Liver fibrosis is a pathological process of chronic liver diseases." | 1.48 | Recombinant truncated TGF‑β receptor II attenuates carbon tetrachloride‑induced epithelial‑mesenchymal transition and liver fibrosis in rats. ( Cao, Y; Chu, Y; Li, H; Li, L; Liu, J; Shi, Y; Yuan, X; Zhang, Z; Zheng, J, 2018) |
| "Liver fibrosis is overly exuberant wound healing that leads to portal hypertension or liver cirrhosis." | 1.48 | Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis. ( Fan, X; Ge, S; He, J; Jia, R; Li, B; Li, P; Li, Y; Ma, X; Pan, H; Shang, Q; Wang, H; Wang, L; Yang, Z; Zhang, H; Zhu, L, 2018) |
| "Celecoxib has been explored as a possible treatment of liver fibrosis with contradictory results, depending on the model." | 1.48 | Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. ( Hammock, BD; Harris, TR; Hwang, SH; Imai, DM; Kodani, S; Rand, AA; Yang, J, 2018) |
| "Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production." | 1.48 | Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes. ( Han, X; Kuang, Y; Wang, Y; Xu, M; Yang, Q; Zhao, Y, 2018) |
| "Acute liver failure is a critical condition characterized by global hepatocyte death and often time needs a liver transplantation." | 1.48 | Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ( Allen, T; Cheng, K; Cores, J; Dinh, PU; Freytes, DO; Hensley, MT; Hu, S; Huang, K; Li, Z; Liang, H; Qiao, L; Shao, C; Shen, D; Su, T; Vandergriff, AC; Wrona, EA; Xing, J; Yu, Z; Zeng, Q; Zhang, H, 2018) |
| "Liver fibrosis is the final common pathway for almost all causes of chronic liver injury." | 1.48 | Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model. ( Alves de Castro, I; Barbisan, LF; Cogliati, B; Crespo Yanguas, S; da Silva, TC; Gijbels, E; Goes, BM; Maes, M; Pereira, IVA; Romualdo, GR; Sayuri Nogueira, M; Shestopalov, VI; Vinken, M; Willebrords, J, 2018) |
| "Adding PSTPIP2 expression alleviates liver fibrosis and hepatic inflammation in mice by regulating macrophage polarization." | 1.48 | PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. ( Huang, C; Huang, HM; Li, HD; Li, J; Li, WX; Li, XF; Lv, XW; Meng, XM; Pan, XY; Wang, H; Wu, XQ; Yang, Y; Zhang, L, 2018) |
| "A rat model of liver fibrosis was generated by administering CCl4 via subcutaneous injection twice a week for 12 weeks." | 1.48 | Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats. ( Liu, F; Ma, Z; Qian, J; Wu, G; Zhang, J, 2018) |
| "Inhibition of ALR expression aggravates liver fibrosis, probably via promoting HSC migration and mitochondrial fusion." | 1.48 | Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell. ( Ai, WL; An, W; Dong, LY; Gao, J; Li, ZW; Wang, J; Wang, X; Wu, Y, 2018) |
| " Our findings support the further development of telmisartan prodrugs that enable infrequent dosing in the treatment of liver fibrosis." | 1.48 | Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs. ( Ackley, JC; Andersen, JN; Baddour, J; Blume-Jensen, P; Brady, SW; Chickering, DE; Economides, KD; Ehrlich, DC; Golder, MR; Held, EJ; Huh, SJ; Johnson, JA; Kopesky, PW; Liu, J; Neenan, AM; Nguyen, HV; Paramasivan, S; Reiter, LA; Saucier-Sawyer, JK; Shipitsin, MV; Vangamudi, B; Vohidov, F, 2018) |
| "The knowledge of pharmacokinetic and pharmacodynamic properties of antiepileptic drugs is helpful in optimizing drug therapy for epilepsy." | 1.46 | Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence. ( Kumar, B; Medhi, B; Modi, M; Saikia, B, 2017) |
| "This study was designed to explore the pharmacokinetic and pharmacodynamic properties of rhubarb anthraquinones extract in diabetic nephropathy and acute liver injury rats." | 1.46 | Pharmacokinetics and pharmacodynamics of rhubarb anthraquinones extract in normal and disease rats. ( Hao, H; Hao, K; Jiang, W; Li, P; Lu, Q; Pei, X; Sun, Y, 2017) |
| "SC-43 significantly ameliorates liver fibrosis through SHP-1 upregulation." | 1.46 | Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. ( Chen, DS; Chen, KF; Chen, LJ; Chen, PJ; Hu, TC; Huang, KW; Huang, YJ; Jao, P; Kao, JH; Liu, CH; Liu, CJ; Shiau, CW; Su, TH; Tai, WT; Tseng, TC; Wu, YM; Yang, HC; Yang, NJ, 2017) |
| "Progressive liver fibrosis leads to cirrhosis and end-stage liver disease." | 1.46 | Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. ( Berardis, S; El Taghdouini, A; El-Kehdy, H; Evraerts, J; Henriet, P; Lombard, C; Najimi, M; Rosseels, V; Sokal, EM; van Grunsven, L, 2017) |
| "M2 macrophages were not effective on liver fibrosis." | 1.46 | Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. ( Bai, J; Dou, KF; Gao, CC; Han, H; Liang, SQ; Ma, PF; Qin, HY; Ye, YC; Yi, J; Zhao, JL; Zhao, Y; Zheng, QJ, 2017) |
| "Detection of liver fibrosis during its earlier stages is a matter of great importance which may allow prevention of development of cirrhosis in patients with chronic liver disease." | 1.46 | Evaluation of liver fibrosis using Raman spectroscopy and infrared thermography: A pilot study. ( Escobedo, G; González, FJ; Guzmán, C; Kershenobich, D; Kolosovas-Machuca, ES; Ramírez-Elías, MG, 2017) |
| "Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type." | 1.46 | A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl ( Braeuning, A; Dooley, S; Hammad, S; Hengstler, JG; Meyer, C; Mohamed, FEZA, 2017) |
| "Elk-3 contributes to the progression of liver fibrosis by modulating the EMT via the regulation of Egr-1 under MAPK signaling." | 1.46 | Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. ( Choi, JE; Hong, SW; Hur, W; Kim, JH; Kim, SM; Lee, EB; Lee, JH; Li, TZ; Yoon, SK, 2017) |
| "However, the role of myricetin on liver fibrosis remains to be elucidated." | 1.46 | The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice. ( Geng, Y; Li, W; Lu, ZM; Shi, JS; Sun, Q; Xu, HY; Xu, ZH, 2017) |
| " The LD50 value at 24 h was approximately 5950 mg/kg." | 1.43 | Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. ( El-Hadary, AE; Ramadan Hassanien, MF, 2016) |
| "To induce liver fibrosis, male Wistar rats received CCl4 (2 ml/kg/2 times/week; i." | 1.43 | Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways. ( Abd el Aziz, GM; El-Desouky, MA; Hasan, IH; Hozayen, WG, 2016) |
| "Hepatocarcinogenesis was significantly accelerated in the fibrotic livers compared to those of the control, significantly decreasing the life span of the mice." | 1.43 | Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. ( Ahn, SH; Cho, KJ; Chung, SI; Han, KH; Ju, HL; Kim, DY; Moon, H; Ro, SW, 2016) |
| "Liver cirrhosis is the common pathological histology manifest among a number of chronic liver diseases and liver cancer." | 1.43 | Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis. ( Cai, Y; Chen, Y; E, C; Li, J; Li, W; Liu, W; Pan, Y; Wu, Q; Zhang, X; Zheng, X, 2016) |
| "Melatonin was administered orally at 2." | 1.43 | Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. ( Hong, JM; Kang, JW; Lee, SM, 2016) |
| "The progression of liver fibrosis, an intrinsic response to chronic liver injury, is associated with hepatic hypoxia, angiogenesis, abnormal inflammation, and significant matrix deposition, leading to the development of cirrhosis and hepatocellular carcinoma (HCC)." | 1.43 | Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis. ( Chan, KM; Chen, Y; Chern, GG; Chiang, T; Hsu, FF; Liu, CH; Liu, JY; Liu, YC; Wu, YH, 2016) |
| "Liver fibrosis was induced by intraperitoneal administration with CCl4." | 1.43 | Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance. ( Deng, WS; Gu, L; Sun, XF; Xu, Q; Zhou, H, 2016) |
| "The present in vivo study revealed that the long term usage of ZES was safe for organs in laboratory animals." | 1.43 | Pharmacological safety evaluation of a traditional herbal medicine "Zereshk-e-Saghir" and assessment of its hepatoprotective effects on carbon tetrachloride induced hepatic damage in rats. ( Mandegary, A; Nematollahi, MH; Pardakhty, A; Sarhadynejad, Z; Sattaie-Mokhtari, S; Sharififar, F, 2016) |
| "Liver fibrosis is a global health problem and previous studies have demonstrated that reactive oxygen species (ROS) play important roles in fibrogenesis." | 1.43 | Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. ( Gao, Y; Gu, J; Kong, X; Sun, X; Wen, Y; Xia, Q; Yu, C; Yu, Y, 2016) |
| "Next, to elucidate the roles of Sfrp5 in liver fibrosis, we investigated a carbon-tetrachloride (CCl4 )-induced liver fibrosis model using Sfrp5 knockout (KO) and wild type (WT) mice in vivo." | 1.42 | Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis. ( Chatani, N; Egawa, M; Ezaki, H; Furuta, K; Hamano, M; Kamada, Y; Kiso, S; Kizu, T; Ogura, S; Ouchi, N; Shimono, A; Takehara, T; Yoshida, Y, 2015) |
| "Histamine levels were evaluated in serum." | 1.42 | Histamine restores biliary mass following carbon tetrachloride-induced damage in a cholestatic rat model. ( Francis, H; Francis, T; Graf, A; Hargrove, L; Harris, R; Hodges, K; Johnson, C; Kennedy, L; Ueno, Y, 2015) |
| "Neuropathic pain was induced by CCI of the sciatic nerve." | 1.42 | Hyperbaric oxygen treatment at various stages following chronic constriction injury produces different antinociceptive effects via regulation of P2X4R expression and apoptosis. ( Ding, YY; Hu, PY; Meng, LX; She, YJ; Song, XR; Tan, YH; Zhao, BS, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "CCl4-induced liver fibrosis protects mice against lethal dose of APAP, Possibly by a mechanism involving inhibition of the cytoplasmic translocation of HMGB1." | 1.42 | [Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury]. ( Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K, 2015) |
| "Liver fibrosis was induced by intraperitoneal injections of carbon tetrachloride (CCl4) or bile duct ligation (BDL) for two weeks." | 1.42 | Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice. ( Choi, HS; Eun, HS; Jeong, WI; Jung, JY; Lee, YS; Park, KG; Park, SH; Suh, JM; Yi, HS, 2015) |
| "Liver fibrosis was induced by repeated intraperitoneal injection of carbon tetrachloride." | 1.42 | Macrophage autophagy protects against liver fibrosis in mice. ( Chobert, MN; Denaës, T; El-Benna, J; Lodder, J; Lotersztajn, S; Pawlotsky, JM; Teixeira-Clerc, F; Wan, J, 2015) |
| " The toxic rat group received CCl4, while the treatment group received CCl4+P." | 1.42 | Effects of Pistacia Atlantica Extract on Erythrocyte Membrane Rigidity, Oxidative Stress, and Hepatotoxicity Induced by CCl4 in Rats. ( Mirzaei, A; Tolooei, M, 2015) |
| "The CCl4‑induced rats exhibited liver fibrosis, increased hydroxyproline content, impaired liver function, upregulated expression levels of the α‑SMA and TGF‑β1 pro‑fibrogenic proteins, and increased expression of HSP70, compared with the control group." | 1.42 | Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70. ( Chen, B; Chen, J; He, W; Qi, L; Shao, D; Wang, L; Wang, M; Zhuang, Y, 2015) |
| "Sesamin was administered in two different dose (5 and 10 ml/kg bw) to evaluate the hepatoprotective activity." | 1.42 | Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat. ( Liu, L; Lv, D; Zhu, CQ, 2015) |
| "In the treatment group, liver fibrosis significantly decreased compared to the model group (P < 0." | 1.42 | Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats. ( Lv, HY; Wang, YL; Zhang, Q, 2015) |
| "Liver fibrosis is a feature in the majority of chronic liver diseases and oxidative stress is considered to be its main pathogenic mechanism." | 1.42 | Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats. ( Bi, XY; Fang, RT; Luo, AL; Ren, GX; Wei, XL; Yang, YH; Zang, WJ; Zhao, M, 2015) |
| "Prednisolone treatment prevents T/NKT cell hepatitis but exacerbates hepatotoxin-induced liver injury by inhibiting macrophage- and neutrophil-mediated phagocytic and hepatic regenerative functions." | 1.40 | Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice. ( Feng, D; Gao, B; Kwon, HJ; Park, O; Won, YS, 2014) |
| "A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used." | 1.40 | Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014) |
| "In the present study, liver fibrosis was induced in wild-type (WT), TLR7-deficient, and IFN-α/β receptor-1 (IFNAR1)-deficient mice and TLR7-mediated signaling was assessed in liver cells isolated from these mice." | 1.40 | Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. ( Kim, B; Kim, JW; Lim, CW; Park, S; Roh, YS; Seki, E, 2014) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 1.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "Decursin treatment significantly reduced the ratio of liver/body weight, α-SMA activation, and type I collagen overexpression in CCl4 treated mice liver." | 1.40 | Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro. ( Choi, YJ; Chung, CH; Jeong, SI; Kim, DH; Kim, J; Kim, SJ; Kim, SY; Yu, KY, 2014) |
| "In 2 groups of SD rats, liver fibrosis was induced in experimental animals by repetitive carbon tetrachloride injections, while the control group received saline injections." | 1.40 | The hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and early liver cirrhosis in a rat model: an experimental study. ( Geng, X; Hao, L; Liu, A; Ma, C; Song, Q; Sun, B; Wang, H; Wang, Y; Zhao, G, 2014) |
| "Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use." | 1.40 | Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model. ( Chanderasekharan, H; Chheda, TK; Madanahalli, JR; Marikunte, VV; Moolemath, Y; Oommen, AM; Sadasivan, SK; Shivakumar, P, 2014) |
| " Both conditions failed to cause a significant effect on Cmax or Tmax." | 1.40 | Effect of experimentally induced hepatic and renal failure on the pharmacokinetics of topiramate in rats. ( Matar, KM; Tayem, YI, 2014) |
| "Advanced liver fibrosis results in cirrhosis and liver failure, and liver transplantation is often the only option for effective therapy; however, the shortage of available donor livers limits this treatment." | 1.40 | Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice. ( Chen, YH; Cheng, PJ; Cheng, WT; Chou, CJ; Kao, YJ; Ko, IC; Peng, SY; Shaw, SW; Wu, SC, 2014) |
| "The model of liver fibrosis was induced by intraperitoneal injection with CCl4 three times per week lasting for 12 weeks in CCl4 group and the BMP-7+CCl4 group." | 1.40 | BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor. ( Cao, ST; Chen, YP; Dong, JZ; Lin, Z; Shi, KQ; Wang, LP; Xiong, LJ; Zhang, SN; Zou, ZL, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| " The LD50 of MSE was more than 5000 mg/kg." | 1.40 | Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice. ( Al-Sayed, E; El-Lakkany, NM; Hammam, OA; Sabra, AN; Seif El-Din, SH, 2014) |
| "Chronic kidney disease, end-stage renal failure, and liver diseases are increasing worldwide and constitute a huge burden on health care costs, with attendant high morbidity and debility." | 1.40 | Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats. ( Akah, PA; Ihim, SA; Laiyemo, KA; Nworu, CS; Ugwu, LE, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Treatment with paeonol significantly protected the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, improving the histological architecture of the liver, and by inhibiting activation of hepatic stellate cells (HSCs) in vivo." | 1.39 | Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies. ( Chen, L; Kong, D; Lu, Y; Wei, D; Zhang, F; Zhang, X; Zheng, S; Zhu, X, 2013) |
| "Two models of rat liver fibrosis, the carbon tetrachloride and bile duct ligation models, were treated with rAAV/siRNA-TIMP-1." | 1.39 | Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis. ( Bai, Y; Chen, J; Cong, M; Cong, R; Fan, X; Jia, J; Li, H; Liu, T; Peng, Z; Tang, S; Tong, X; Wang, B; Wang, P; Wu, P; Yang, A; You, H, 2013) |
| "In contrast, no change in liver fibrosis was observed in BDL-cirrhotic rats but an increase in the eNOS pathway." | 1.39 | Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats. ( Bosch, J; García-Calderó, H; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Tripathi, D, 2013) |
| " At the studying of the bile formation and bile secretion functions in the conditions of the toxic tetrachlormethane lesion the hepatoprotective effect of the dosage form was confirmed, which was realized by the increasing of the speed of bile secretion and its volume." | 1.39 | [Studying of hepatoprotective properties of dry extract from apricot leaves on the model of liver lesion by tetrachloromethane]. ( Fira, LS; Likhatskiĭ, PG; Medvid', II; Pyla, VP; Shtroblia, AL; Vashkeba, EM, 2013) |
| "The gold standard in assessing liver fibrosis is biopsy despite limitations like invasiveness and sampling error and complications including morbidity and mortality." | 1.39 | Molecular MRI of collagen to diagnose and stage liver fibrosis. ( Caravan, P; Fuchs, BC; Lauwers, GY; Parkar, A; Polasek, M; Schühle, DT; Sinskey, AJ; Tanabe, KK; Wang, H; Wei, L; Yang, Y, 2013) |
| "To induce liver fibrosis in this model, rats were given a subcutaneous injection of a 40% solution of CCl4 in olive oil at a dose of 0." | 1.39 | Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathway. ( Cao, Q; Fan, FG; Guo, XL; Jin, J; Jin, L; Lan, R; Liang, B; Wang, XC; Wang, XW; Yang, JH, 2013) |
| " The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs (NSAIDs) and carbon tetrachloride (CCl4)." | 1.39 | Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis. ( Asif, HM; Jamil, A; Jamil, MS; Mahmood, Z; Roohi, M; Saeed, A; Usmanghani, K, 2013) |
| "Liver fibrosis was induced in male C57BL/6N mice by injecting a 10% CCl(4) solution intraperitoneal twice a week for six weeks." | 1.39 | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. ( Chen, M; Cheng, Q; Huang, C; Li, N; Li, Q; Lin, Q; Qian, Z; Shi, G; Wang, X; Zheng, J, 2013) |
| "Using two liver cirrhosis mouse models induced by CCl4 or thioacetamide, we showed that targeting AR in the BM-MSCs improved their self-renewal and migration potentials and increased paracrine effects to exert anti-inflammatory and anti-fibrotic actions to enhance liver repair." | 1.39 | Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis. ( Chang, C; Huang, CK; Lai, KP; Lee, SO; Lin, TH; Luo, J; Ma, WL; Tsai, MY, 2013) |
| " Hepatic endothelial function was assessed in isolated and perfused rat livers by dose-response curves to acetylcholine (ACh) and methoxamine (Mtx)." | 1.39 | Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats. ( Abrante, B; Abreu, P; de Ganzo, ZA; Felipe, V; González-Méndez, Y; Hernández-Guerra, M; Moreno, M; Quintero, E; Salido, E, 2013) |
| " Liver function tests and histopathological evaluation were carried out at the end of dosing using standards kits." | 1.39 | Hepatoprotective effect of herbal drug on CCl(4) induced liver damage. ( Feroz, Z; Khan, RA, 2013) |
| " Moreover, we evaluated endothelial function by dose-relaxation curves to acetylcholine, hepatic NO bioavailability and TXA2 production." | 1.39 | Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; Di Pascoli, M; Diví, M; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Vilaseca, M, 2013) |
| "FHL2(-/-) mice displayed aggravated liver fibrosis compared to wt mice." | 1.39 | Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. ( Adam, AC; Büttner, R; Goltz, D; Huss, S; Khlistunova, I; Kirfel, J; Stellmacher, C; Trebicka, J; Weiskirchen, R, 2013) |
| "Azelnidipine is a calcium blocker that has been shown to have antioxidant effects in endothelial cells and cardiomyocytes." | 1.38 | Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. ( Horiguchi, N; Ichikawa, T; Izumi, T; Kakizaki, S; Kishimoto, K; Mori, M; Ohyama, T; Sato, K; Takagi, H; Yamazaki, Y, 2012) |
| "Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ." | 1.38 | A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. ( Ebinuma, H; Hibi, T; Hiroi, S; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Miura, S; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Sugiyama, K; Suzuki, T; Teratani, T; Tominaga, S; Tomita, K; Yokoyama, H, 2012) |
| " However, DDB therapeutic effectiveness is restricted by its low oral bioavailability that arises from its poor solubility and dissolution." | 1.38 | Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation. ( Abdelbary, GA; Aburahma, MH, 2012) |
| "Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia." | 1.38 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. ( Beisner, J; Bevins, CL; Hofmann, C; Nuding, S; Schoelmerich, J; Stange, EF; Teltschik, Z; Wehkamp, J; Wiest, R, 2012) |
| "Carbon tetrachloride was used to induce acute liver injury in mice; cells or secreted proteins were administered by intrasplenic or intraperitoneal injection, respectively." | 1.38 | Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. ( Ahn, EK; Chenoweth, JG; Choi, TH; Heo, J; Hoeppner, DJ; Hong, SH; Kang, GY; Kim, JH; Kim, SE; Kim, SK; Kim, Y; Kwon, H; Lee, JH; Lim, HJ; McKay, RD; Park, HS; Song, KW; Tesar, PJ; Woo, DH; You, HJ, 2012) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver injury in TP knockout (TP(-/-)) mice and wild-type (WT) mice." | 1.38 | Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. ( Ae, T; Hosono, K; Ito, Y; Koizumi, W; Majima, M; Minamino, T; Narumiya, S; Ohkubo, H; Sakagami, H; Sato, T; Shibuya, A; Suzuki, T, 2012) |
| "Oleuropein is a non-toxic secoiridoid found in the leaves and fruits of olive (Olea europaea L." | 1.38 | Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. ( Domitrović, R; Jakovac, H; Marchesi, VV; Rahelić, D; Romić, Ž; Šain, I, 2012) |
| " The plant proved to be safe for human use because it did not induce any signs of toxicity or mortality in mice when administered orally at doses up to 5000 mg kg(-1)." | 1.38 | Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats. ( Alqasoumi, SI; Awaad, AS; El-Gindi, OD; El-Sayed, DF; Soliman, GA, 2012) |
| " Nitric oxide (NO) bioavailability and eNOS activation were measured in hepatic endothelial cells (HEC) isolated from cirrhotic rat livers." | 1.38 | PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; García-Calderó, H; García-Pagán, JC; Laviña, B; Rodríguez-Vilarrupla, A; Roglans, N; Rosado, E; Russo, L, 2012) |
| "Xanthohumol was applied orally at a dose of 1 mg/g body weight 2 days prior as well as during and after exposure to CCl(4)." | 1.38 | Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis. ( Dorn, C; Heilmann, J; Hellerbrand, C, 2012) |
| "Phenacetin metabolism was impaired more severely in 6 rats that died than in 21 living rats (P < 0." | 1.38 | Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury. ( Cai, M; He, P; Li, X; Liu, Z; Qu, Z; Wang, X; Xiao, J; Zhou, M, 2012) |
| "Molecular MRI of liver fibrosis with a collagen-specific probe identifies fibrotic tissue in two rodent models of disease." | 1.38 | Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. ( Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S, 2012) |
| " However, due to its impermeability across the gastrointestinal mucosa, oral bioavailability of the drug was relatively low." | 1.38 | Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles. ( Fu, S; Han, J; Jin, S; Lu, Y; Lv, Q; Qi, J; Wu, W; Yuan, H, 2012) |
| "In the experimental group, liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride." | 1.38 | Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: an animal study. ( Huang, YP; Lau, TY; Lee, ES; Leung, G; Tipoe, GL; Ying, M; Yuen, QW; Zheng, YP, 2012) |
| "Metabolomics has been frequently used in pharmacodynamic studies, especially those on traditional Chinese medicine (TCM)." | 1.38 | Radix Paeoniae Rubra and Radix Paeoniae Alba Attenuate CCl4-induced acute liver injury: an ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) based metabolomic approach for the pharmacodynamic study of Traditional Chinese Medicines (TCMs) ( Shi, YH; Teng, ZQ; Wang, R; Xiong, AZ; Yang, L; Yang, QW, 2012) |
| " In conclusion, the nanoemulsification method may be applied for poor water-soluble ethanolic herbal extracts to reduce the dosage and time." | 1.38 | Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats. ( Deepa, V; Goparaju, A; Murthy, PB; Reddy, PN; Sridhar, R, 2012) |
| "Curcumin was significantly returned the expression levels of mir-199 and -200 with their associated target gene nearly to their normal levels." | 1.38 | Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis. ( Al-Olayan, EM; Hassan, ZK, 2012) |
| "Carbon tetrachloride (CCl(4)) is a common hepatotoxin used in experimental models to elicit liver injury." | 1.37 | Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. ( Fan, ST; Jiang, PP; Jor, IW; Lee, CY; Ling, WL; Man, K; Sit, WH; Tam, KT; Wan, JM; Wong, LL, 2011) |
| " Advanced liver fibrosis was induced in female mice by chronic administration of carbon tetrachloride." | 1.37 | Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. ( Forbes, SJ; Gordon-Walker, TT; Hartland, S; Hume, DA; Iredale, JP; Pope, C; Ramachandran, P; Robson, AJ; Thomas, JA; Van Deemter, M; Wojtacha, D, 2011) |
| "Oxidative stress is related to the liver fibrosis, anticipating the hepatic stellate cells' (HSC) activation." | 1.37 | Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis. ( Catoi, C; Clichici, S; Daicoviciu, D; Decea, N; Filip, A; Gherman, C; Login, C; Mocan, T; Moldovan, R; Muresan, A; Nagy, A, 2011) |
| "Using a mouse liver fibrosis model, we show that carbon tetrachloride treatment induces ADAMTS1 expression in parallel to that of type I collagen." | 1.37 | Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta. ( Baffet, G; Bonnier, D; Bourd-Boittin, K; Ezan, F; Leyme, A; Mari, B; Samson, M; Theret, N; Tuffery, P, 2011) |
| "Our results showed that the induced NAFLD and insulin resistance (IR) were accompanied with hyperglycemia and hyperlipidemia and lowered brain glucose level with elevated ATPase activity, prooxidant status (TBARS level, xanthine oxidase and cytochrome 2E1 activities), and inflammatory markers." | 1.37 | Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. ( Ghareeb, DA; Hafez, HS; Hussien, HM; Kabapy, NF, 2011) |
| "The methanol extract was purified by repeated column chromatography, resulting in the identification of five metabolites whose hepatoprotective effects were evaluated by measuring aspartate transaminase, alanine transaminase, alkaline phosphatase, glutamate, total bilirubin level, lactate dehydrogenase, total serum protein, and lipid peroxidation (thiobarbituric acid reactive substances assay) in CCl(4)-induced hepatic injury in mice." | 1.37 | Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice. ( Anaya Sosa, I; Hoyo Vadillo, C; Perez Gutierrez, RM; Victoria, TC, 2011) |
| "Experimental liver fibrosis was induced by subcutaneous injection of CCl4." | 1.37 | [Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats]. ( Bao, JF; Shi, JP; Xu, S, 2011) |
| "Liver fibrosis is regulated by an epigenetic relay pathway that includes MeCP2, EZH2, and miR132." | 1.36 | MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. ( Chu, DC; Mann, DA; Mann, J; Maxwell, A; Oakley, F; Tsukamoto, H; Zhu, NL, 2010) |
| "Since liver fibrosis frequently occurs before hepatoma development, this study investigated the expression profile of HDGF and its relationship with transforming growth factor-beta (TGF-beta) signaling in experimental models of hepatofibrogenesis." | 1.36 | Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis. ( Chan, HH; Chao, D; Chen, CL; Cheng, KH; Cheng, YF; Chung, YH; Goto, S; Hu, TH; Jawan, B; Kao, YH; Kuo, SM; Lin, YC; Sun, CK; Tai, MH; Wu, DC, 2010) |
| "Treatment with cystamine and garlic extract reduced the liver fibrosis and collagen deposition, particularly in the garlic extract group (p<0." | 1.36 | Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase. ( Amoruso, DC; Caporaso, N; D'Argenio, G; D'Armiento, MR; Fogliano, V; Mazzone, G; Mezza, E; Morisco, F; Ribecco, MT; Romano, A; Vitaglione, P, 2010) |
| "Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective." | 1.36 | Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010) |
| "MSCs caused a decrease in liver fibrosis histopathologically, 4 weeks after transplantation." | 1.36 | Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. ( Azhdari, Z; Baharvand, H; Gharavi, M; Piryaei, A; Rabani, V; Shahsavani, M, 2010) |
| " Using a bivascular liver perfusion dose-response curves to adenosine of the HA were performed in the presence and the absence of pan-adenosine blocker (8-SPT), A1 blocker (caffeine) or nitric oxide synthase-blocker (l-NMMA) after preconstriction with an alpha1-agonist (methoxamine)." | 1.36 | A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver. ( Groszmann, RJ; Mehal, WZ; Ripoll, C; Zipprich, A, 2010) |
| "Glycogen was decreased by CCl(4), while celecoxib partially prevented and reversed this effect." | 1.36 | Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat. ( Castro-Sánchez, L; Chávez, E; Moreno, MG; Muriel, P; Salazar, EP; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2010) |
| "All mice developed liver fibrosis." | 1.36 | Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. ( Brenner, DA; Gu, G; Iwaisako, K; Kisseleva, T; Osterreicher, CH; Scholten, A; Scholten, D, 2010) |
| "Carbon tetrachloride (CCl(4))-treated mouse model in vivo and in hepatic stellate cells (HSC) in vitro were used." | 1.36 | Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production. ( Hu, LH; Li, CJ; Liu, Q; Shen, X; Wang, X; Zhang, Y, 2010) |
| "Although pharmacokinetic alternations by hepatic injury have been extensively studied, little is known about the potential influence of hepatoprotective agent's treatment." | 1.36 | Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers. ( Dai, C; Hao, H; Kang, A; Li, J; Liang, Y; Sun, S; Wang, G; Xie, L; Xie, T; Xie, Y; Zheng, X, 2010) |
| "Hydroxyproline, which is an indicator of fibrosis in liver tissue, was high in the ethanol-treated control group." | 1.36 | Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. ( Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER, 2010) |
| "Fulminant hepatitis or acute liver failure (ALF), initiated by viral infection or hepatic toxin, is a devastating medical complication without effective therapeutic treatment." | 1.35 | Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. ( Han, YP; Yan, C; Zhou, L, 2008) |
| "To induce liver fibrosis, C57BL6 female mice were injected i." | 1.35 | Platelets contribute to the reduction of liver fibrosis in mice. ( Aoyagi, Y; Fukunaga, K; Hashimoto, I; Ikeda, O; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N; Watanabe, M; Yasue, H, 2009) |
| "After transplantation into mice with acute liver failure, ASC-derived hepatocytes can restore such liver functions as ammonia and purine metabolism." | 1.35 | Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. ( Banas, A; Kato, T; Ochiya, T; Okochi, H; Osaki, M; Takeshita, F; Teratani, T; Tokuhara, M; Yamamoto, Y, 2009) |
| "To this end, liver fibrosis was induced in AR+/+ and AR-/- mice by chronic CCl(4) administration." | 1.35 | The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. ( Avila, MA; Berasain, C; Cartagena-Lirola, H; Castillo, J; Goñi, S; Latasa, MU; Lotersztajn, S; Nicou, A; Perugorria, MJ; Prieto, J; Vespasiani-Gentilucci, U; Zagami, MG, 2008) |
| " Chronic administration of CCl(4) for 12 weeks led to an increase of collagen type I and a decrease of type III in the wall of aorta." | 1.35 | Red wine polyphenols affect the collagen composition in the aorta after oxidative damage induced by chronic administration of CCl(4). ( Andriantsitohaina, R; Babal, P; Cerna, A; Hlavackova, L; Janega, P; Pechanova, O, 2009) |
| "Taurine treatment reduced fibrosis scores significantly as compared to placebo." | 1.35 | Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury. ( Comert, B; Mas, MR; Mas, N; Tasci, I; Tuncer, M, 2008) |
| " The circulating levels of apelin, the messenger RNA (mRNA) and protein expression of apelin and apelin receptor, the immunohistological detection of apelin and apelin receptor, and the effects induced by the chronic administration of an apelin receptor antagonist on fibrosis and vessel density were evaluated in rats with cirrhosis and ascites and in control rats." | 1.35 | The hepatic apelin system: a new therapeutic target for liver disease. ( Arroyo, V; Bernardi, M; del Arbol, LR; Fernández-Varo, G; Jiménez, W; Melgar-Lesmes, P; Morales-Ruiz, M; Principe, A; Ros, J, 2008) |
| "Several in vitro studies have demonstrated the ability of pure trans-resveratrol (t-Res) to act as an anti-oxidant, but the scientific literature is lacking in in vivo studies dealing with dietary t-Res bioavailability in oxidative stress models." | 1.35 | Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. ( Caporaso, N; Fogliano, V; Milani, S; Morisco, F; Ottanelli, B; Vitaglione, P, 2009) |
| "A novel naringenin-loaded nanoparticles system (NARN) was developed to resolve the restricted bioavailability of naringenin (NAR) and to enhance its hepatoprotective effects in vivo on oral administration." | 1.35 | Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl(4)-induced acute liver failure. ( Cham, TM; Lin, CC; Lin, LT; Wu, TH; Yen, FL, 2009) |
| "CXCR3(-/-) mice had increased liver fibrosis; progression was associated with decreased numbers of intrahepatic interferon gamma-positive T cells and reduced interferon gamma messenger RNA, indicating that CXCL9-CXCR3 regulates Th1-associated immune pathways." | 1.35 | Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. ( Berg, T; Berres, ML; Dahl, E; Friedman, SL; Gassler, N; Hellerbrand, C; Hillebrandt, S; Keppeler, H; Lammert, F; Schmitz, P; Scholten, D; Streetz, KL; Tacke, F; Trautwein, C; Wasmuth, HE; Weiskirchen, R; Zaldivar, MM; Zimmermann, H, 2009) |
| "Liver index and the degree of liver fibrosis were also determined." | 1.35 | Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. ( Chen, LJ; Dai, LL; He, CM; Huang, CQ; Peng, XD; Yang, B, 2009) |
| "The progression of toxic hepatitis is accompanied by the activation of oxidative processes in the liver associated with an enhancement of the mitochondrial respiratory chain activity and superoxide anion production (O(2)(*-))." | 1.35 | Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis. ( Arkadyeva, A; Emelyanova, L; Morozov, V; Sakuta, G; Shiryaeva, A, 2009) |
| "The glycogen content was 50% higher in experimental group compared to the control." | 1.35 | [Comparative morphofunctional analysis of rat hepatocyte cultures isolated from the normal and pathologically changed liver due to experimental toxic hepatitis]. ( Baĭdiuk, EV; Bezborodkina, NN; Sakuta, GA; Shiriaeva, AP, 2009) |
| "Deficiency of tPA aggravated liver fibrosis through promoting hepatic stellate cells (HSCs) activation and inhibiting ECM degradation by decreasing MMP-2, MMP-9 activities and disrupting the balance between MMP-13 and TIMP-1." | 1.35 | Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis. ( Hsiao, Y; Hu, H; Ling, CC; Song, HY; Tao, XM; Zou, T, 2008) |
| "Adenosine is a potent endogenous regulator of tissue repair that is released from injured cells and tissues." | 1.35 | Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. ( Chan, ES; Chiriboga, L; Cronstein, BN; Fernandez, P; Peng, Z; Wilder, T; Yee, H, 2008) |
| " In addition, in CH livers, PP dose-response curves to the NO donor, S-nitroso-N-acetyl-D,L-penicillamine (SNAP), were performed after pre-incubation with Ibtx or its vehicle." | 1.35 | Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis. ( Abraldes, JG; Bataller, R; Bosch, J; García-Pagán, JC; Graupera, M; Matei, V; Rodríguez-Vilarrupla, A, 2008) |
| "Lethal fulminant hepatic failure in nonobese diabetic severe combined immunodeficient mice was induced by carbon tetrachloride gavage." | 1.35 | Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. ( Chen, CT; Chuang, CH; Fang, SC; Hung, SP; Kuo, TK; Lee, OK; Shih, YR; Yang, VW, 2008) |
| "We treated carbon tetrachloride (CCl(4)) into rats for eight weeks to induce liver fibrosis and arranged these rats for cholinergic denervation, hepatic branch vagotomy or atropine administration." | 1.35 | Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. ( Cheng, JT; Cheng, KC; Hsu, CT; Lam, HB; Yeh, CH, 2008) |
| "Bakuchiol treatment stimulated the activation of extracellular signal-regulated kinase 1/2 (ERK), c-Jun NH2-terminal protein kinase (JNK), and p38 mitogen-activated protein kinases (MAPK) in vitro." | 1.34 | Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. ( Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ, 2007) |
| "We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium in 66 rabbits randomly treated with 0." | 1.34 | The pharmacodynamics of mivacurium in the rabbit with carbon tetrachloride-induced liver disease. ( Cheong, MA; Kim, KS; Lee, GS, 2007) |
| "Hydroxyproline was 504." | 1.34 | Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats. ( Cao, BQ; Chen, R; Huang, SB; Lin, JZ; Lin, N; Tang, ZF; Xiang, P; Xu, RY; Zhong, YS, 2007) |
| "Advanced liver cirrhosis is associated with hyperdynamic circulation consisting of systemic hypotension, decreased peripheral resistance, and cardiac dysfunction, termed cirrhotic cardiomyopathy." | 1.34 | Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. ( Bátkai, S; Harvey-White, J; Kechrid, R; Kunos, G; Mukhopadhyay, P; Pacher, P, 2007) |
| "The extent and kinetic of the disease progression were followed by the measurement of ultrasound backscatter intensity." | 1.34 | Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice. ( Champy, MF; D'Sa, A; Garo, E; Guimond, A; Monassier, L; Selloum, M; Teletin, M; Vonesch, JL, 2007) |
| "Liver necrosis was induced by administering a single intraperitoneal (i." | 1.34 | Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats. ( Antić-Stanković, J; Kotur-Stevuljević, J; Milenković, M; Stefanović, A; Topić, A; Uskoković-Marković, S, 2007) |
| "The model for inducing liver cirrhosis in rats was established according to a previously published protocol." | 1.34 | Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. ( Guo, H; Hao, ZM; Li, YC; Xue, H, 2007) |
| " Treatment of the toxic hepatitis with heptral increased the level of cytochrome P450, cytochrome b5, glutation activity of glutationetranspherase glutathione and reduced content of homocysteine." | 1.34 | [Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]. ( Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN, 2007) |
| "Gabexate mesilate treatment significantly decreased the elevation of serum transaminase levels and improved liver histology 24 h after the administration of CCl4 (0." | 1.33 | Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats. ( Goto, T; Kataoka, E; Lin, JG; Mikami, K; Miura, K; Ohshima, S; Segawa, D; Shibuya, T; Watanabe, D; Watanabe, S; Yoneyama, K, 2005) |
| "Bicyclol is a novel synthetic drug for the treatment of chronic viral hepatitis in China." | 1.33 | Mechanism of protective action of bicyclol against CCl-induced liver injury in mice. ( Li, Y; Liu, GT; Wei, HL; Xu, JY; Yu, LH; Zhang, H, 2005) |
| " However, the increase in CCl(4) dosage significantly worsened survival." | 1.33 | Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. ( Chang, ML; Chang, PY; Chen, JC; Yeh, CT, 2005) |
| " With repetitive dosing CCl(4) can be used to induce bridging hepatic fibrosis (4 wk of twice-weekly dosing), cirrhosis (8 wk of twice-weekly dosing) and advanced micronodular cirrhosis (12 wk of twice-weekly dosing)." | 1.33 | Modeling liver fibrosis in rodents. ( Constandinou, C; Henderson, N; Iredale, JP, 2005) |
| "Liver cirrhosis was induced by intraperitoneal administration of CCl4 at a dose of 0." | 1.33 | Cryopreserved fetal liver cell transplants support the chronic failing liver in rats with CCl4-induced cirrhosis. ( Fuller, BJ; Mazur, SP; Ochenashko, OV; Petrenko, AY; Somov, AY; Volkova, NA, 2006) |
| "Immune-induced and CCL4-induced liver fibrosis models were established by dexamethasone (0." | 1.33 | Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models. ( Li, J; Luo, XD; Nie, QH; Shao, B; Xie, YM; Zhang, YF; Zhou, YX, 2006) |
| "The only novel protein with regard to liver fibrosis depicting a unidirectional expression pattern in both animal models was Sbp2." | 1.33 | Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis. ( Berres, ML; Graf, J; Henkel, C; Hillebrandt, S; Lammert, F; Meyer, HE; Roderfeld, M; Roeb, E; Stühler, K; Weiskirchen, R, 2006) |
| "Rat liver fibrosis was induced by subcutaneous injection of tetrachloride (CCl4)." | 1.33 | Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats. ( Chen, H; Cong, X; Fei, R; Gao, Y; Liu, F; Wang, Y; Wei, L; Zhan, Y, 2006) |
| "Hepatic encephalopathy is a neurologic syndrome secondary to liver failure that causes cognitive and motor abnormalities." | 1.33 | Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis. ( Bartolí, R; Chatauret, N; Córdoba, J; Odena, G; Oria, M; Planas, R; Raguer, N, 2006) |
| "Aniline was ring hydroxylated in liver microsomes but not in nuclei from either control or EtOH-treated animals." | 1.33 | Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet. ( Castro, GD; Castro, JA; Delgado de Layño, AM; Diaz Gómez, MI; Fanelli, SL, 2006) |
| "Retrorsine pretreatment did not affect sensitivity for carbon tetrachloride." | 1.32 | Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute? ( Aselmann, H; Bahlmann, FH; Dahlke, MH; Jäger, MD; Klempnauer, J; Neipp, M; Piso, P; Popp, FC; Schlitt, HJ, 2003) |
| "Liver cirrhosis was inflicted in rats by percutaneous injection of 40% CCl4 on the back." | 1.32 | Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis. ( Liu, QG; Ma, QY; Pan, CE; Yang, W; Yao, YM; Zhang, M, 2003) |
| "We have developed a type 2 diabetes rat model that closely resembles the diabetic patients and takes only 24 days to develop robust diabetes." | 1.32 | Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. ( Dnyanmote, AV; Latendresse, JR; Limaye, PB; Mehendale, HM; Sawant, SP; Shankar, K, 2004) |
| "Candesartan cilexetil treatment significantly reduced the fibrosis development." | 1.32 | Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis. ( Bayram, I; Ozbek, H; Tuncer, I; Ugras, S, 2003) |
| "Hepatic cirrhosis was induced in male Sprague-Dawley rats by intraperitoneal injection of carbon tetrachloride, and the cirrhotic rats were divided into three groups:Liposome-pcDNA(3)/iNOS (n = 10), Tris buffer (n = 10) and nude plasmid (n = 10), which were injected into the portal vein of experiment cirrhotic rats respectively." | 1.32 | [Experimental study on iNOS gene transfer mediated by liposome to treat portal hypertension in cirrhotic rats]. ( Luo, HF; Qiu, JF; Wu, ZY; Zhang, ZQ, 2004) |
| "CCl4-induced liver fibrosis enhanced lipid peroxidation and TIMPs activation, increased ALT and AST, depleted antioxidants SOD and GPx, and caused collagen deposition in liver tissue." | 1.32 | The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. ( Avenoso, A; Calatroni, A; Campo, GM; Campo, S; D'Ascola, A; Ferlazzo, AM, 2004) |
| "Our data suggest that liver cirrhosis induced by CCl4 or TAA is associated with alterations in cell cycle-related proteins, and that the expression of these proteins is responsible for hepatocyte regeneration in the damaged liver and may be involved in liver carcinogenesis." | 1.31 | Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide. ( Jang, JJ; Jeong, DH; Lee, JH; Lee, MJ; Lee, SJ; Lee, YS; Lim, IK, 2001) |
| "Liver cirrhosis was induced by CCl(4) inhalation and phenobarbital in Wistar rats." | 1.31 | Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats. ( Castilla-Cortázar, I; García, M; Muguerza, B; Prieto, J; Quiroga, J; Santidrián, S, 2001) |
| "In rats with acute hepatic failure, the hepatic P-glycoprotein concentration increased 1." | 1.31 | Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure. ( Huang, ZH; Murakami, T; Nagai, J; Okochi, A; Takano, M; Yumoyo, R, 2001) |
| "Gliotoxin treatment significantly reduced the number of activated stellate cells and mean thickness of bridging fibrotic septae in livers from rats treated with carbon tetrachloride." | 1.31 | Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. ( Arthur, MJ; Iredale, JP; Issa, R; Mann, DA; Murray, GI; Primrose, JN; Smart, DE; Trim, N; Wright, MC, 2001) |
| " This simple and sensitive assay method was feasibly applied to the pharmacokinetic study of propranolol after intravenous administration of 2 mg/kg of propranolol to normal and carbon tetrachloride-induced liver cirrhotic rats." | 1.31 | Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection. ( Hong, JH; Kang, JS; Kim, HK; Lee, MH; Park, MS, 2001) |
| " We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1)." | 1.31 | Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. ( Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y, 2002) |
| "Carbon tetrachloride (CCl4) was fed by gavage to rats, and 2, 7, 14, and 28 days later, small and large cholangiocytes were isolated." | 1.30 | Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. ( Alpini, G; Baiocchi, L; Benedetti, A; Caligiuri, A; Francis, H; Glaser, S; Lasater, J; LeSage, GD; Marucci, L; Phinizy, JL; Rodgers, R; Tretjak, Z; Ugili, L, 1999) |
| " Animals pretreated with this hepatotoxic agent showed a significant prolongation in the half-life of diazepam in plasma that is due more to an increase in volume of distribution rather than to a decrease in clearance." | 1.28 | Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury. ( Díaz-García, JM; Fos-Galve, D; Oliver-Botana, J, 1992) |
| "Medroxyprogesterone acetate (MPA) has an inducing effect on the hepatic drug-metabolizing enzyme system in the rat." | 1.27 | Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury. ( Kärki, NT; Saarni, HU; Sotaniemi, EA; Stengård, J, 1983) |
| "This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (2.73) | 18.7374 |
| 1990's | 55 (6.26) | 18.2507 |
| 2000's | 208 (23.69) | 29.6817 |
| 2010's | 473 (53.87) | 24.3611 |
| 2020's | 118 (13.44) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, S | 3 |
| Kong, F | 2 |
| Sun, Z | 3 |
| Xi, Y | 1 |
| Qi, F | 1 |
| Sun, J | 5 |
| Chen, J | 17 |
| Martin-Mateos, R | 1 |
| Li, J | 26 |
| Yin, Z | 1 |
| Lu, X | 3 |
| Glaser, KJ | 1 |
| Mounajjed, T | 1 |
| Yashiro, H | 1 |
| Siegelman, J | 1 |
| Winkelmann, CT | 1 |
| Wang, J | 14 |
| Ehman, RL | 1 |
| Shah, VH | 4 |
| Yin, M | 2 |
| Ogbonna Okoro, C | 1 |
| Aloke, C | 1 |
| Ibiam, UA | 1 |
| Obasi, NA | 1 |
| Orji, OU | 1 |
| Ogbonnia, EC | 1 |
| Ogbu, PN | 1 |
| Emelike, CU | 1 |
| Ufebe, GO | 1 |
| Nwamaka Ezeani, N | 1 |
| Xu, G | 2 |
| Lv, X | 1 |
| Feng, Y | 1 |
| Li, H | 16 |
| Chen, C | 2 |
| Lin, H | 2 |
| Wang, C | 8 |
| Wang, S | 8 |
| Ding, Y | 6 |
| Dong, R | 1 |
| Wang, H | 18 |
| Yin, L | 3 |
| Meng, S | 1 |
| Sun, BR | 1 |
| Li, HY | 2 |
| Wang, GP | 1 |
| Jia, QA | 1 |
| Zhang, C | 10 |
| Almundarij, TI | 1 |
| Alharbi, YM | 1 |
| Abdel-Rahman, HA | 1 |
| Barakat, H | 2 |
| Le, TV | 1 |
| Dinh, NBT | 1 |
| Dang, MT | 1 |
| Phan, NCL | 1 |
| Dang, LTT | 1 |
| Grassi, G | 1 |
| Holterman, AXL | 1 |
| Le, HM | 1 |
| Truong, NH | 1 |
| Li, X | 15 |
| Zhang, S | 10 |
| Zhang, R | 3 |
| Wei, Y | 3 |
| Yang, C | 5 |
| Zhang, F | 9 |
| Zhou, H | 6 |
| Chu, S | 1 |
| Bi, H | 2 |
| Cui, L | 2 |
| He, W | 3 |
| Tian, Y | 2 |
| Liu, F | 4 |
| Gao, G | 1 |
| Wang, Z | 10 |
| Chen, N | 1 |
| Márquez-Quiroga, LV | 1 |
| Arellanes-Robledo, J | 1 |
| Vásquez-Garzón, VR | 1 |
| Villa-Treviño, S | 1 |
| Muriel, P | 4 |
| Ge, S | 3 |
| Yang, W | 3 |
| Chen, H | 5 |
| Yuan, Q | 2 |
| Liu, S | 4 |
| Zhao, Y | 10 |
| Zhang, J | 14 |
| Zhang, YW | 1 |
| Tu, LL | 1 |
| Zhang, Y | 17 |
| Pan, JC | 1 |
| Zheng, GL | 1 |
| Yin, LN | 1 |
| Hu, D | 3 |
| Huang, S | 3 |
| Zhao, X | 3 |
| Zhang, W | 6 |
| Kostallari, E | 1 |
| Wei, B | 1 |
| Sicard, D | 1 |
| Cooper, SA | 1 |
| Gao, J | 5 |
| Dehankar, M | 1 |
| Li, Y | 13 |
| Cao, S | 3 |
| Tschumperlin, DJ | 1 |
| Ren, Z | 2 |
| Huo, Y | 1 |
| Zhang, Q | 5 |
| Chen, S | 4 |
| Lv, H | 1 |
| Peng, L | 1 |
| Wei, H | 3 |
| Wan, C | 2 |
| Shaban, NZ | 1 |
| El-Kot, SM | 1 |
| Awad, OM | 1 |
| Hafez, AM | 1 |
| Fouad, GM | 1 |
| Yuan, Z | 1 |
| He, J | 6 |
| Xie, T | 2 |
| Zhou, M | 3 |
| Chen, TT | 1 |
| Shi, LP | 1 |
| He, Y | 5 |
| Shao, M | 1 |
| Che, JY | 1 |
| Xu, H | 6 |
| Yuan, Y | 3 |
| Huang, H | 3 |
| Wu, X | 4 |
| Fu, J | 3 |
| Xiong, Y | 2 |
| Wen, S | 1 |
| Fang, B | 1 |
| Li, C | 8 |
| Huang, Q | 3 |
| Lin, X | 1 |
| Faccioli, LAP | 1 |
| Dias, ML | 1 |
| Paranhos, BA | 1 |
| Dos Santos Goldenberg, RC | 1 |
| Engelmann, C | 1 |
| Habtesion, A | 1 |
| Hassan, M | 1 |
| Kerbert, AJ | 1 |
| Hammerich, L | 2 |
| Novelli, S | 1 |
| Fidaleo, M | 1 |
| Philips, A | 1 |
| Davies, N | 1 |
| Ferreira-Gonzalez, S | 1 |
| Forbes, SJ | 3 |
| Berg, T | 2 |
| Andreola, F | 1 |
| Jalan, R | 1 |
| Zhao, T | 2 |
| Han, Z | 3 |
| Qiao, H | 2 |
| Gao, N | 1 |
| Oates, JR | 1 |
| Sawada, K | 1 |
| Giles, DA | 1 |
| Alarcon, PC | 1 |
| Damen, MSMA | 1 |
| Szabo, S | 1 |
| Stankiewicz, TE | 1 |
| Moreno-Fernandez, ME | 1 |
| Divanovic, S | 1 |
| Nevzorova, YA | 2 |
| Weiskirchen, R | 8 |
| Liedtke, C | 3 |
| Czekaj, P | 1 |
| Król, M | 1 |
| Kolanko, E | 1 |
| Limanówka, Ł | 1 |
| Prusek, A | 1 |
| Skubis-Sikora, A | 1 |
| Bogunia, E | 1 |
| Sikora, B | 1 |
| Hermyt, M | 1 |
| Michalik, M | 1 |
| Grajoszek, A | 1 |
| Pająk, J | 1 |
| Guillard, J | 1 |
| Untereiner, V | 1 |
| Garnotel, R | 1 |
| Boulagnon-Rombi, C | 1 |
| Gobinet, C | 1 |
| Proult, I | 1 |
| Sockalingum, GD | 1 |
| Thiéfin, G | 1 |
| Qiuling, L | 1 |
| Qilin, Y | 1 |
| Cheng, Y | 4 |
| Minping, Z | 1 |
| Kangning, W | 1 |
| Enhua, X | 1 |
| Mohammadalipour, A | 1 |
| Hashemnia, M | 1 |
| Goudarzi, F | 1 |
| Ravan, AP | 1 |
| Pickich, MB | 1 |
| Hargrove, MW | 1 |
| Phillips, CN | 1 |
| Healy, JC | 1 |
| Moore, AN | 1 |
| Roberts, MD | 1 |
| Martin, JS | 1 |
| Shankaraiah, RC | 1 |
| Callegari, E | 1 |
| Guerriero, P | 1 |
| Rimessi, A | 1 |
| Pinton, P | 1 |
| Gramantieri, L | 1 |
| Silini, EM | 1 |
| Sabbioni, S | 1 |
| Negrini, M | 1 |
| Liu, J | 17 |
| Kong, D | 2 |
| Qiu, J | 3 |
| Xie, Y | 2 |
| Lu, Z | 2 |
| Zhou, C | 3 |
| Liu, X | 10 |
| Wang, Y | 27 |
| Rong, X | 1 |
| Yang, Y | 11 |
| Zhang, G | 2 |
| Zhang, H | 10 |
| Maeso-Díaz, R | 1 |
| Boyer-Diaz, Z | 1 |
| Lozano, JJ | 2 |
| Ortega-Ribera, M | 1 |
| Peralta, C | 1 |
| Bosch, J | 7 |
| Gracia-Sancho, J | 4 |
| Xu, P | 3 |
| Yao, J | 3 |
| Ji, J | 2 |
| Shi, H | 6 |
| Jiao, Y | 1 |
| Hao, S | 1 |
| Chen, D | 3 |
| Zhang, L | 11 |
| Zhou, D | 3 |
| Yan, X | 2 |
| Zhu, J | 5 |
| Xiao, P | 1 |
| Chen, T | 4 |
| Xie, X | 1 |
| Liu, T | 3 |
| Luo, X | 2 |
| Li, ZH | 1 |
| Wu, JC | 1 |
| Luo, SZ | 1 |
| Xu, MY | 1 |
| Zhong, F | 2 |
| Zhou, X | 8 |
| Xu, J | 5 |
| Gao, L | 4 |
| Ye, L | 1 |
| Yu, Y | 2 |
| Fishman, P | 1 |
| Cohen, S | 1 |
| Itzhak, I | 1 |
| Amer, J | 2 |
| Salhab, A | 1 |
| Barer, F | 1 |
| Safadi, R | 2 |
| Kurahashi, T | 1 |
| Yoshida, Y | 3 |
| Ogura, S | 2 |
| Egawa, M | 2 |
| Furuta, K | 2 |
| Hikita, H | 1 |
| Kodama, T | 1 |
| Sakamori, R | 1 |
| Kiso, S | 3 |
| Kamada, Y | 3 |
| Wang, IC | 1 |
| Eguchi, H | 1 |
| Morii, E | 1 |
| Doki, Y | 1 |
| Mori, M | 3 |
| Kalinichenko, VV | 1 |
| Tatsumi, T | 1 |
| Takehara, T | 2 |
| Yun, H | 1 |
| Duan, X | 1 |
| Xiong, W | 1 |
| Kang, J | 1 |
| Pu, X | 1 |
| Chen, Z | 2 |
| Zhao, L | 4 |
| Liang, J | 2 |
| Rao, W | 1 |
| Cui, M | 1 |
| Ren, S | 2 |
| Xu, D | 3 |
| Han, Q | 1 |
| Zang, YJ | 1 |
| Zhang, B | 1 |
| Wu, BM | 1 |
| Liu, JD | 1 |
| Li, YH | 1 |
| Wu, H | 5 |
| Chen, G | 2 |
| Deng, M | 1 |
| Yuan, F | 2 |
| Gong, J | 1 |
| Zhao, J | 4 |
| Han, M | 3 |
| Zhou, L | 7 |
| Liang, P | 2 |
| Feng, S | 1 |
| Lu, H | 3 |
| Yuan, X | 2 |
| Han, K | 1 |
| Chen, X | 7 |
| Cheng, J | 1 |
| Xiang, X | 1 |
| Feng, D | 4 |
| Hwang, S | 2 |
| Ren, T | 2 |
| Wang, X | 16 |
| Trojnar, E | 1 |
| Matyas, C | 1 |
| Mo, R | 1 |
| Shang, D | 1 |
| Seo, W | 2 |
| Pacher, P | 2 |
| Xie, Q | 1 |
| Gao, B | 5 |
| Chi, G | 1 |
| Pei, JH | 1 |
| Ma, QY | 2 |
| Ru, YX | 1 |
| Feng, ZH | 1 |
| Cao, D | 1 |
| Min, L | 1 |
| Wang, G | 5 |
| Liu, HL | 1 |
| Lv, J | 1 |
| Zhao, ZM | 1 |
| Xiong, AM | 1 |
| Tan, Y | 3 |
| Glenn, JS | 1 |
| Tao, YY | 2 |
| Weng, HL | 2 |
| Liu, CH | 5 |
| Chale-Dzul, J | 1 |
| Pérez-Cabeza de Vaca, R | 1 |
| Quintal-Novelo, C | 1 |
| Olivera-Castillo, L | 1 |
| Moo-Puc, R | 1 |
| Deng, Y | 1 |
| Hou, L | 1 |
| Fan, X | 4 |
| Lin, L | 2 |
| Zhao, W | 2 |
| Jiang, K | 1 |
| Sun, C | 3 |
| Xie, S | 1 |
| Qi, H | 2 |
| Li, Q | 5 |
| Zhang, K | 1 |
| Shen, W | 2 |
| Fan, G | 1 |
| Ya, Y | 1 |
| Ni, X | 1 |
| Hou, J | 3 |
| Yu, R | 1 |
| Tang, Y | 1 |
| Ma, N | 1 |
| Luo, H | 1 |
| Yu, F | 2 |
| Zhou, Z | 4 |
| Qi, J | 2 |
| Kim, JW | 2 |
| You, MJ | 1 |
| Lim, CW | 2 |
| Kim, B | 2 |
| Terkelsen, MK | 1 |
| Bendixen, SM | 1 |
| Hansen, D | 1 |
| Scott, EAH | 1 |
| Moeller, AF | 1 |
| Nielsen, R | 1 |
| Mandrup, S | 1 |
| Schlosser, A | 1 |
| Andersen, TL | 1 |
| Sorensen, GL | 1 |
| Krag, A | 2 |
| Natarajan, KN | 1 |
| Detlefsen, S | 1 |
| Dimke, H | 1 |
| Ravnskjaer, K | 1 |
| Ma, R | 1 |
| Martínez-Ramírez, AS | 1 |
| Borders, TL | 1 |
| Gao, F | 1 |
| Sosa-Pineda, B | 1 |
| Kopilakkal, R | 1 |
| Musuvathi, BM | 1 |
| Liu, D | 1 |
| Qin, H | 1 |
| Yang, B | 2 |
| Du, B | 1 |
| Yun, X | 1 |
| Mao, Y | 3 |
| Wu, J | 4 |
| Feng, J | 1 |
| Wu, L | 4 |
| Yu, Q | 2 |
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| Biliczki, F | 1 |
| Ray, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study on the Value of Quantitative MRI Imaging in Diffuse Liver Diseases[NCT04626492] | 150 participants (Anticipated) | Observational [Patient Registry] | 2020-08-01 | Recruiting | |||
| Serelaxin To Lower Portal Pressure in Patients With Cirrhosis and Portal Hypertension[NCT02669875] | Phase 2 | 15 participants (Actual) | Interventional | 2017-10-18 | Completed | ||
| A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma[NCT01356628] | Phase 2 | 23 participants (Actual) | Interventional | 2011-05-25 | Active, not recruiting | ||
| Umbilical Cord Mesenchymal Stem Cell Transfusion in Patients With Severe Liver Cirrhosis[NCT01233102] | Phase 1/Phase 2 | 200 participants (Anticipated) | Interventional | 2009-10-31 | Suspended | ||
| The Effects of Leucine and Isoleucine on Glucose Metabolism[NCT02634164] | 12 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia[NCT03395028] | Early Phase 1 | 6 participants (Actual) | Interventional | 2018-01-15 | Completed | ||
| Mesenchymal Stem Cell Therapy for Liver Cirrhosis: A Phase I/II Study[NCT03626090] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2018-08-18 | Recruiting | ||
| Phase Ⅰ/Ⅱ Study of Human Umbilical Cord Derived Mesenchymal Stem Cells (UC-MSCs) for Treatment of Liver Failure[NCT01218464] | Phase 1/Phase 2 | 70 participants (Anticipated) | Interventional | 2009-03-31 | Recruiting | ||
| A Randomised, Controlled Trial of Losartan as an Anti-fibrotic Agent in Non-alcoholic Steatohepatitis[NCT01051219] | Phase 3 | 45 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number and nature of adverse events as a measure of safety and tolerability. Safety analysis will be conducted on all patients who receive at least one dose of PD-0332991 during the study period or follow-up. An adverse event is any unfavorable and unintended sign, symptom, syndrome or illness that develops during the period of observation in the clinical study, including a new illness or condition, worsening of a concomitant illnesses or condition, effect of the study medication or combination of 2 or more factors. (NCT01356628)
Timeframe: From date of randomization through study completion, assessed up to 100 months
| Intervention | Adverse Events (Number) |
|---|---|
| PD-0332991 | 504 |
Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST Version 1.1), as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). The appearance of one or more new lesions is also considered progression. (NCT01356628)
Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
| Intervention | months (Mean) |
|---|---|
| PD-0332991 | 8 |
15 reviews available for carbon tetrachloride and Disease Models, Animal
| Article | Year |
|---|---|
Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Diseas | 2022 |
Liver cirrhosis: An overview of experimental models in rodents.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Cirrhosis, Expe | 2022 |
Rodent Models of Nonalcoholic Fatty Liver Disease.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cholesterol, Dietary; Combined Modality Therapy; Diet, | 2020 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Topics: Action Potentials; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics; Animals; Anti-Inflamma | 2016 |
Animal models of drug-induced liver injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2019 |
Role of hemostatic factors in hepatic injury and disease: animal models de-liver.
Topics: Animals; Bile Ducts; Blood Coagulation; Blood Coagulation Disorders; Carbon Tetrachloride; Chemical | 2016 |
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Disease Models, Animal; Galactosamine; Hepatectomy; Hu | 2009 |
[Meta-analysis on impact of Danshen on liver regeneration in rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2012 |
Mouse models of liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Liver Ci | 2007 |
Liver damage due to free radicals.
Topics: Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 1993 |
Animal models of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Experimental; Liver Diseases | 1993 |
Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow.
Topics: Animals; Ascites; Bile Ducts; Blood Flow Velocity; Carbon Tetrachloride; Disease Models, Animal; Hem | 2001 |
Hepatocyte swelling and portal hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatomegaly; Hypertension, Portal; Liver; Li | 1992 |
Intravascular coagulation in liver disease.
Topics: Animals; Blood Coagulation Factors; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Di | 1974 |
3 trials available for carbon tetrachloride and Disease Models, Animal
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspartate | 1997 |
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
Topics: Animals; Antineoplastic Agents; Biopsy; Carbon Tetrachloride; Dimethylnitrosamine; Disease Models, A | 2001 |
861 other studies available for carbon tetrachloride and Disease Models, Animal
| Article | Year |
|---|---|
Hepatoprotective effect and metabonomics studies of radix gentianae in rats with acute liver injury.
Topics: Administration, Oral; Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Dose-Respon | 2021 |
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Elasticity Ima | 2021 |
Studies on Ethanol Extracts of
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2021 |
Study on the effect of active components of Schisandra chinensis on liver injury and its mechanisms in mice based on network pharmacology.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Disease Mod | 2021 |
Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase.
Topics: Activating Transcription Factor 4; Adenylate Kinase; Animals; Aspartate-Ammonia Ligase; Canagliflozi | 2021 |
C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
Topics: Adipokines; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix; Gene Knocko | 2021 |
Antioxidant Activity, Phenolic Profile, and Nephroprotective Potential of
Topics: Animals; Antioxidants; Brassicaceae; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Kidney; | 2021 |
Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroquine; Disea | 2022 |
Protective effect of Idelalisib on carbon tetrachloride-induced liver fibrosis via microRNA-124-3P/phosphatidylinositol-3-hydroxykinase signalling pathway.
Topics: Animals; Apoptosis; Biomarkers; Biopsy; Carbon Tetrachloride; Disease Models, Animal; Disease Suscep | 2021 |
Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl
Topics: Animals; Antifibrotic Agents; Carbon Tetrachloride; Cysteine; Disease Models, Animal; Gene Knockdown | 2021 |
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemokine CXCL2; Coculture Techniques; Disease Models, Ani | 2021 |
Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Disease Mod | 2021 |
Specnuezhenide reduces carbon tetrachloride-induced liver injury in mice through inhibition of oxidative stress and hepatocyte apoptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; | 2022 |
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Huma | 2022 |
Protective Effect of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Supplem | 2021 |
The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Carbon Tetrachloride; Carica | 2021 |
Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis.
Topics: Actins; Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Antioxidants; Carbon Tetrachloride; | 2021 |
Topics: Agaricales; Animals; Animals, Outbred Strains; Antioxidants; Carbon Tetrachloride; Chemical and Drug | 2022 |
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis.
Topics: Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herb | 2022 |
Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF.
Topics: Acute-On-Chronic Liver Failure; Animals; Carbon Tetrachloride; Disease Models, Animal; Galactosamine | 2022 |
Effect of ADHI on hepatic stellate cell activation and liver fibrosis in mice.
Topics: Alcohol Dehydrogenase; Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatic Stellate Cells | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Infla | 2023 |
Mouse Models for Hepatic Stellate Cell Activation and Liver Fibrosis Initiation.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver; Liver | 2023 |
Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Human | 2023 |
Longitudinal Study of Cirrhosis Development in STAM and carbon tetrachloride Mouse Models Using Fourier Transform Infrared Spectral Imaging.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fourier Analysis; Glycogen; Liver Cirrhosis; | 2023 |
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosi | 2023 |
Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis.
Topics: Animals; Atorvastatin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Drug Evaluatio | 2019 |
Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemokine CCL5; Chemokine CX3CL1; Curcumin; | 2019 |
Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease M | 2019 |
Praziquantel ameliorates CCl
Topics: Animals; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Gene Expression; Hepatic Stellate | 2019 |
Antler stem cells as a novel stem cell source for reducing liver fibrosis.
Topics: Actins; Animals; Antlers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Collagen; | 2020 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li | 2019 |
Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Carbon Tetrachlori | 2019 |
Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow; Carbon Tetrachloride; Cell | 2019 |
Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α.
Topics: Adipokines; Animals; Carbon Tetrachloride; Carrier Proteins; Diet, High-Fat; Disease Models, Animal; | 2019 |
Icariin-induced miR-875-5p attenuates epithelial-mesenchymal transition by targeting hedgehog signaling in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Disease Models, Animal; Epithelial-Mesench | 2020 |
The A3 adenosine receptor agonist, namodenoson, ameliorates non‑alcoholic steatohepatitis in mice.
Topics: Actins; Adenosine A3 Receptor Agonists; Adiponectin; Animals; Carbon Tetrachloride; Disease Models, | 2019 |
Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cells, Cultured; Chemokine CCL2; Disease M | 2020 |
Exploration of the Hepatoprotective Effect and Mechanism of Swertia mussotii Franch in an Acute Liver Injury Rat Model.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herbal; High-Throughput Screen | 2019 |
Cross-regulation by TLR4 and T cell Ig mucin-3 determines severity of liver injury in a CCl4-induced mouse model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2020 |
Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling.
Topics: Animals; Biopsy; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Gene Expression Regulation | 2020 |
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Kupffer Cells | 2020 |
TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways.
Topics: Adenine; Alanine; Animals; Antiviral Agents; Carbon Tetrachloride; Disease Models, Animal; DNA-Bindi | 2020 |
Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice.
Topics: Acute Disease; Acute-On-Chronic Liver Failure; Adult; Animals; Carbon Tetrachloride; Chemical and Dr | 2020 |
Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Topics: Adenoviridae; Animals; Autoantigens; Autoimmunity; Biomarkers; Biopsy; Carbon Tetrachloride; CD4-Pos | 2020 |
Mediator MED23 regulates inflammatory responses and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemokine CCL5; Chemokine CXCL10; Disease Models, Animal; | 2019 |
Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis.
Topics: Animals; Capillaries; Carbon Tetrachloride; Disease Models, Animal; Drugs, Chinese Herbal; Endotheli | 2019 |
Hepatoprotective effect of a fucoidan extract from Sargassum fluitans Borgesen against CCl
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Gene Expressi | 2020 |
Genipin Ameliorates Carbon Tetrachloride-Induced Liver Injury in Mice via the Concomitant Inhibition of Inflammation and Induction of Autophagy.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2019 |
Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Image Processing, Computer-Assisted; Inflamma | 2020 |
Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Early Diagnosis; Humans; Liver; Liver Cirrhos | 2019 |
Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Down-Regulation; | 2020 |
AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity
Topics: Animals; Antioxidants; Apoptosis; Benzamides; Carbon Tetrachloride; Cells, Cultured; Chemical and Dr | 2020 |
Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.
Topics: Animals; Biopsy; Capillaries; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2020 |
Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.
Topics: Age Factors; Animals; Biomarkers; Capillaries; Carbon Tetrachloride; Claudin-2; Disease Models, Anim | 2020 |
Evaluation of Hepatoprotective Activity of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clerodendrum; C | 2020 |
Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome.
Topics: Animals; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Diterpenes, Kaurane; Hepatic Stell | 2020 |
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Topics: Alginates; Animals; Autophagy; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Down-Regula | 2020 |
Lignans from Schisandra chinensis ameliorate alcohol and CCl
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver I | 2020 |
Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling.
Topics: Alginates; Animals; Carbon Tetrachloride; Cell Line; Cell Movement; Cell Proliferation; Cell Surviva | 2020 |
A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol; Disease Models, | 2020 |
Intravenous Administration is the Best Route of Mesenchymal Stem Cells Migration in Improving Liver Function Enzyme of Acute Liver Failure.
Topics: 5'-Nucleotidase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetra | 2020 |
Dysregulation of bile acids increases the risk for preterm birth in pregnant women.
Topics: Adolescent; Adult; Animals; Bile Acids and Salts; Carbon Tetrachloride; Cholic Acid; Disease Models, | 2020 |
Huagan tongluo Fang improves liver fibrosis via down-regulating miR-184 and up-regulating FOXO1 to inhibit Th17 cell differentiation.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cell Differentiation; Disease Models, Animal; Down-Reg | 2020 |
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carbon Tetrachloride; Carcinogenesis; Car | 2021 |
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Carbon Tetrachloride; Disease Mode | 2020 |
Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Male; Mesenchymal Ste | 2021 |
Camellia oil (Camellia oleifera Abel.) attenuates CCl
Topics: Animals; Apoptosis; Camellia; Carbon Tetrachloride; Disease Models, Animal; Hepatocytes; Liver Cirrh | 2020 |
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Benzyl Alcohols; Carbon Tetrachloride; Disease Models | 2020 |
Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis; Mice; Mice, Knockout; Micros | 2020 |
Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Carbon Tetrachloride; Disease | 2020 |
Therapeutic potential of bone marrow-derived mesenchymal stem cells and imatinib in a rat model of liver fibrosis.
Topics: Animals; Bone Marrow; Carbon Tetrachloride; Combined Modality Therapy; Disease Models, Animal; Imati | 2020 |
Dendrobium nobile Lindl. alkaloids-mediated protection against CCl
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2020 |
Evaluation of carbon tetrachloride fraction of Actinodaphne angustifolia Nees (Lauraceae) leaf extract for antioxidant, cytotoxic, thrombolytic and antidiarrheal properties.
Topics: Animals; Antidiarrheals; Antioxidants; Artemia; Carbon Tetrachloride; Castor Oil; Defecation; Diarrh | 2020 |
hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis.
Topics: Animals; Benzofurans; Biomarkers; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cu | 2020 |
Diffusion tensor imaging quantifying the severity of chronic hepatitis in rats.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Diffusion Tensor Imaging; Disease Models, Anima | 2020 |
Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice.
Topics: Animals; Apoptosis; Biopsy; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2020 |
Gut Microbiota and Liver Fibrosis: One Potential Biomarker for Predicting Liver Fibrosis.
Topics: Animals; Bacteria; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Feces; Gastrointestinal | 2020 |
Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Chemical and Drug Induced Liver Injury; Disease Models | 2020 |
Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation.
Topics: Actins; Angiotensin II; Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Cells, Cul | 2020 |
Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2020 |
MiR-126 Regulates Properties of SOX9
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cell Differentiation; Cell Line, Tumor; Cell Prolifera | 2020 |
Intravenous Umbilical Cord-derived Mesenchymal Stem Cells Transplantation Regulates Hyaluronic Acid and Interleukin-10 Secretion Producing Low-grade Liver Fibrosis in Experimental Rat.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fetal Blood; Hyaluronic Acid; Interleukin-10; | 2020 |
Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Disease Sus | 2020 |
The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Regulatory Networks; Genetic Predisposit | 2021 |
Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2020 |
Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Anim | 2020 |
Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of
Topics: Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride; Chenopodium quinoa; Disease Models, Anim | 2020 |
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Che | 2020 |
SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling.
Topics: Animals; Benzamides; Carbon Tetrachloride; Cell Line; Dioxoles; Disease Models, Animal; Drug Liberat | 2020 |
Tanshinone IIA exerts therapeutic effects by acting on endogenous stem cells in rats with liver cirrhosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease Models, | 2020 |
Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bile Ducts; Carbon Tetrachloride; Cell Proliferation; | 2021 |
MicroRNA-125a/VDR axis impaired autophagic flux and contributed to fibrosis in a CCL4-induced mouse model and patients with liver cirrhosis.
Topics: Animals; Antagomirs; Autophagy; Base Sequence; Carbon Tetrachloride; Dependovirus; Disease Models, A | 2021 |
MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Disease | 2020 |
Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Carotenoids; Disease Models, | 2021 |
Comparing distress of mouse models for liver damage.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Diseases; Mice | 2020 |
AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.
Topics: Adenylate Kinase; Alanine Transaminase; Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Model | 2020 |
Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cell Proliferati | 2020 |
A role for intestinal alkaline phosphatase in preventing liver fibrosis.
Topics: Adult; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Common Bile Duct; Disease Models, Animal | 2021 |
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Topics: Adenosine; Animals; Apoptosis; Benzazepines; Bile Ducts; Carbon Tetrachloride; Cell Cycle; Cell Cycl | 2021 |
Association of CX3CL1 and CX3CR1 Expression with Liver Fibrosis in a Mouse Model of Schistosomiasis.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dise | 2020 |
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Topics: Animals; Berberine Alkaloids; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Extracellula | 2021 |
Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chlorocebus aethiops; Collagen; Disease Models, Animal | 2021 |
Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver | 2021 |
Elevated miR-129-5p attenuates hepatic fibrosis through the NF-κB signaling pathway via PEG3 in a carbon CCl
Topics: Animals; Base Sequence; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Kruppel-Like | 2021 |
Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis.
Topics: Animals; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Cell Line; Di | 2021 |
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Topics: Acute Lung Injury; Animals; Carbon Tetrachloride; Cell Line; Cellular Senescence; Coculture Techniqu | 2021 |
Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Cytokines; Disease Models, A | 2021 |
Combination of aqueous extracts of Curcuma longa (turmeric) and some calcium channel blockers synergistically improves CCl4-induced nephrotoxicity in albino rats.
Topics: Acute Kidney Injury; Amlodipine; Animals; Antioxidants; Calcium Channel Blockers; Carbon Tetrachlori | 2020 |
Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2020 |
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Collagen; Disease Models, Ani | 2021 |
Starch based hydrogel NPs loaded by anthocyanins might treat glycogen storage at cardiomyopathy in animal fibrotic model.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cardiomyopathies; Cardiotoxicity; Disease Models, Anima | 2021 |
Inhibition of the transient receptor potential vanilloid 3 channel attenuates carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdow | 2021 |
RUNX1 regulates SMAD1 by transcriptionally activating the expression of USP9X, regulating the activation of hepatic stellate cells and liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cell Survival; Core Binding Factor | 2021 |
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Re | 2021 |
Mouse Models of Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Hepatic Stellate Cells; Human | 2021 |
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Topics: 5'-Nucleotidase; Acetaldehyde; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Ca | 2021 |
Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells.
Topics: Animals; Capillaries; Carbon Tetrachloride; Disease Models, Animal; Endothelial Cells; Fatty Acid-Bi | 2021 |
Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2021 |
Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Ind | 2021 |
Hepatoprotective Effects of Polysaccharide from
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Free Radical Scavengers; Lipid | 2021 |
Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2021 |
Comparison of the Effects of Intraperitoneal Injection with Carbon Tetrachloride on Acute Liver Toxicity in Male and Female Kunming Mice.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2021 |
Extracellular vesicles from in vivo liver tissue accelerate recovery of liver necrosis induced by carbon tetrachloride.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Extracellular | 2021 |
Knockout of the Cannabinoid Receptor 2 Gene Promotes Inflammation and Hepatic Stellate Cell Activation by Promoting A20/Nuclear Factor-κB (NF-κB) Expression in Mice with Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Susceptibility; | 2021 |
Caveolin-1 Deficiency Protects Mice Against Carbon Tetrachloride-Induced Acute Liver Injury Through Regulating Polarization of Hepatic Macrophages.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Caveolin 1; Chemical and Drug Induced Liver In | 2021 |
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cell L | 2021 |
Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbon Tetrachl | 2017 |
Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Interleukin-6; Ligation; Liver Cirrhosis, Bil | 2017 |
Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, | 2017 |
Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress.
Topics: Animals; Antioxidants; Biopsy; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver | 2017 |
Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; bcl-2-Associated X Protein | 2017 |
Can Ultrasound Imaging Predict the Success of an Experimental Steatofibrosis Model?
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Female; Humans; | 2017 |
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; | 2017 |
Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.
Topics: Adult; Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Down-Regulation; Female; He | 2017 |
Pharmacokinetics and pharmacodynamics of rhubarb anthraquinones extract in normal and disease rats.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chromatography, High Pressure L | 2017 |
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells.
Topics: Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Di | 2017 |
Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Remodeling | 2017 |
Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, | 2017 |
Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Culture Media, | 2017 |
Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice.
Topics: Animals; Antigens, Ly; Apoptosis; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Cellular Mic | 2017 |
Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton's jelly mesenchymal stromal cells.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Disease Models, Animal; Epithelial Cell | 2017 |
Bone marrow endothelial progenitor cells activate hepatic stellate cells and aggravate carbon tetrachloride induced liver fibrosis in mice via paracrine factors.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultured; Coculture Techniques; Culture Med | 2017 |
Screening for the protective effect target of deproteinized extract of calf blood and its mechanisms in mice with CCl4-induced acute liver injury.
Topics: Actihaemyl; Animals; Apoptosis; Blood Proteins; Blotting, Western; Carbon Tetrachloride; Disease Mod | 2017 |
Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cell Proliferation; C | 2017 |
Evaluation of liver fibrosis using Raman spectroscopy and infrared thermography: A pilot study.
Topics: Animals; Carbon Tetrachloride; Discriminant Analysis; Disease Models, Animal; Drug Dosage Calculatio | 2017 |
Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Endotoxins; Gastrointestinal Micro | 2017 |
Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress.
Topics: Actins; Animals; Carbon Tetrachloride; CD11b Antigen; Cell Separation; Cell- and Tissue-Based Therap | 2017 |
A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type IV; Disease Models, Animal; Glutamate-Ammonia L | 2017 |
Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Benzopyrans; Camellia sinensis; Carbon Tetrachloride; Disease Models, Animal; Humans; Liver | 2017 |
Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver | 2017 |
Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Liver Cir | 2017 |
Evaluation of Rumex hastatus leaves against hepatic fibrosis: a rat model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2017 |
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
Topics: Adaptor Proteins, Signal Transducing; Angiopoietin-2; Animals; Carbon Tetrachloride; Cell Cycle Prot | 2018 |
Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Cell Movement; Cell Polarity; Chemotaxis; Disea | 2017 |
Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix; Fibrillar Collagens; Im | 2017 |
Protective potential of Parrotiopsis jacquemontiana (Decne) Rehder on carbon tetrachloride induced hepatotoxicity in experimental rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Dise | 2017 |
Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats.
Topics: Animals; Benzoates; Carbon Tetrachloride; Disease Models, Animal; Epoxide Hydrolases; Hypertension, | 2018 |
Changes in hydrogen sulfide in rats with hepatic cirrhosis in different stages.
Topics: Animals; Carbon Tetrachloride; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Model | 2017 |
Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Collagen; Disease Models, Anima | 2017 |
Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2017 |
A hepatonephro-protective phenolic-rich extract from red onion (Allium cepa L.) peels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemi | 2017 |
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Disease Progress | 2017 |
Serum metabonomics study of the hepatoprotective effect of amarogentin on CCl
Topics: Animals; Biomarkers; Carbon Tetrachloride; Discriminant Analysis; Disease Models, Animal; Drugs, Chi | 2018 |
Recombinant truncated TGF‑β receptor II attenuates carbon tetrachloride‑induced epithelial‑mesenchymal transition and liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellu | 2018 |
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2018 |
FOXA2 alleviates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene | 2017 |
Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cytokines; Disease Models, Animal; Gene Express | 2018 |
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Extrac | 2017 |
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 9; Chemical and Drug Induced Liver Injury; Curcumi | 2018 |
Potential roles of AMP-activated protein kinase in liver regeneration in mice with acute liver injury.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemic | 2018 |
Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10.
Topics: Actins; Androstadienes; Animals; Anti-Inflammatory Agents; Aromatase Inhibitors; Bile Ducts; Carbon | 2017 |
Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; | 2018 |
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MELILOTUS OFFICINALIS L. AGAINST PARACETAMOL AND CARBON TETRACHLORIDE INDUCED HEPATIC INJURY IN MICE.
Topics: Acetaminophen; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cy | 2017 |
SENP2 alleviates CCl
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Lin | 2018 |
Cav-1 deficiency promotes liver fibrosis in carbon tetrachloride (CCl
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Caveolin 1 | 2018 |
Bone marrow or adipose tissue mesenchymal stem cells: Comparison of the therapeutic potentials in mice model of acute liver failure.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Disease Models, Anima | 2018 |
Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Dise | 2018 |
Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Celecoxib; Collagen; Cycloox | 2018 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2018 |
Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Citric Acid Cyc | 2018 |
In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Coumarins; Cyclooxygenase 2; Disease Models | 2018 |
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.
Topics: Animals; Apoptosis; Biomimetic Materials; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disea | 2018 |
Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Connexins; Disease Models, Animal; Gene Expression Regula | 2018 |
PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.
Topics: 5' Untranslated Regions; Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carbon Tetrachlo | 2018 |
Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Emodin; Epithelial-Mese | 2018 |
Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl₄-Induced Hepatic Fibrosis Animal Model.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Disease Models, Animal; Epithelial-Mesenchymal Transit | 2018 |
Treatment Efficiency of Different Routes of Bone Marrow-Derived Mesenchymal Stem Cell Injection in Rat Liver Fibrosis Model.
Topics: Actins; Administration, Intravenous; Animals; Bone Marrow Cells; Carbon Tetrachloride; Connective Ti | 2018 |
Quantitative analysis of susceptibility-weighted magnetic resonance imaging in chronic hepatitis in rats.
Topics: Animals; Carbon Tetrachloride; Diagnosis, Differential; Disease Models, Animal; Evaluation Studies a | 2018 |
Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice.
Topics: Animals; Apoptosis; Biological Products; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2018 |
[Effect of Jiawei Yinchen Sini Decoction on the Production of Smad7 and CollagenⅠ,Ⅲ in Carbon Tetrachloride Induced Hepatic Fibrosis Model of Mice].
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Laminin; Liv | 2016 |
Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae).
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
Topics: Actins; Animals; Calcium; Carbon Tetrachloride; Cell Line; Cell Movement; Disease Models, Animal; Ge | 2018 |
Brachychiton populneus (Schott & Endl.) R.Br. ameliorate carbon tetrachloride induced oxidative stress through regulation of endoplasmic reticulum stress markers and inflammatory mediators in Sprague-Dawley male rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chromatography, High Pressure | 2018 |
DGCR5 attenuates neuropathic pain through sponging miR-330-3p and regulating PDCD4 in CCI rat models.
Topics: Animals; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Disease Models, Animal; Female; Gene E | 2019 |
P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation.
Topics: Animals; Apoptosis; Artemether; Carbon Tetrachloride; Cell Death; Cell Proliferation; Disease Models | 2019 |
Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; | 2018 |
Protective effects of
Topics: Animals; Anti-Inflammatory Agents; Antimutagenic Agents; Bidens; Carbon Tetrachloride; Chemical and | 2021 |
Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Arylamine N-Acetyltransferase; Autophagosomes; Au | 2019 |
Formulation and biopharmaceutical evaluation of supersaturatable self-nanoemulsifying drug delivery systems containing silymarin.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemistry, Pharmaceutical; Disease Models, A | 2019 |
Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Therapy, Combination; Eugenol; Glutathio | 2019 |
Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure.
Topics: Amnion; Animals; Carbon Tetrachloride; Disease Models, Animal; Epithelial Cells; Hepatocytes; Hetero | 2018 |
Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis.
Topics: Actins; Animals; Atorvastatin; Azepines; Carbon Tetrachloride; Chitosan; Disease Models, Animal; Dru | 2019 |
Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein.
Topics: Actins; Animals; Carbon Tetrachloride; Cloning, Molecular; Disease Models, Animal; Down-Regulation; | 2018 |
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expre | 2016 |
Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Concanavalin A | 2018 |
Conversion of Fibroblasts to Hepatocyte-Like Cells In Vivo.
Topics: Animals; Carbon Tetrachloride; Cell Lineage; Cellular Reprogramming; Dependovirus; Disease Models, A | 2019 |
Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Dise | 2019 |
Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl
Topics: Adenoviridae; Animals; Bone Marrow Cells; Carbon Tetrachloride; Disease Models, Animal; Genetic Ther | 2018 |
Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice.
Topics: Animals; Antioxidants; Brassica rapa; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2019 |
Liver Macrophage Depletion Ameliorates The Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver.
Topics: Animals; Biometry; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2019 |
Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis.
Topics: Adenosine Triphosphate; Amino Acids, Branched-Chain; Animals; Body Weight; Carbon Tetrachloride; Dis | 2018 |
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle Proteins; | 2019 |
Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Dise | 2019 |
SVIP alleviates CCl
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Survival; Disease Models, Animal; Hep G2 Cells; Hepat | 2019 |
Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Apoptosis; Carbon Tetrachlo | 2019 |
Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling.
Topics: Animals; Axin Protein; beta Catenin; Biopsy, Needle; Carbon Tetrachloride; Cells, Cultured; Disease | 2019 |
Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Indu | 2019 |
Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury.
Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemi | 2019 |
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdown Techniques; H | 2019 |
Human bone marrow-derived mesenchymal stromal cells in combination with silymarin regulate hepatocyte growth factor expression and genotoxicity in carbon tetrachloride induced hepatotoxicity in Wistar rats.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2019 |
Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Count; Cells, Cultured; Disease Models, Animal; Gene Exp | 2019 |
d-amino acid modification protects N-Acetyl-seryl-aspartyl-lysyl-proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis.
Topics: Actins; Amino Acids; Angiotensin-Converting Enzyme Inhibitors; Animals; Carbon Tetrachloride; Cell P | 2019 |
Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.
Topics: Animals; Apoptosis; Becaplermin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibr | 2019 |
Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.
Topics: Animals; Binding Sites; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Down-Regulati | 2019 |
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Carbon Tetrachloride; Disease Models, Animal; Drug | 2018 |
Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Coenzyme A; Disease Models, Animal; Ferroptosis; Hum | 2019 |
Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells.
Topics: Angiogenesis Inducing Agents; Animals; Bone Marrow Cells; Carbon Tetrachloride; Disease Models, Anim | 2019 |
Animal models for hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Disease Models, Animal; Gene Editing; Huma | 2019 |
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Elect | 2019 |
Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Topics: Animals; Carbon Tetrachloride; China; Cichorium intybus; Disease Models, Animal; Ethnicity; Female; | 2019 |
TG101348, a selective JAK2 antagonist, ameliorates hepatic fibrogenesis
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; | 2019 |
Zerumbone Protects against Carbon Tetrachloride (CCl
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2019 |
Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis.
Topics: Actins; Animals; Base Sequence; Carbon Tetrachloride; Cell Cycle Proteins; Cells, Cultured; Chemokin | 2019 |
Combination of CCl
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; | 2019 |
Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Hepatic Stel | 2019 |
Hepatoprotective effect of ketoconazole in chronic liver injury model.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Death; Chemical and Drug Induced Liver Injury; Disease M | 2019 |
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Topics: Adult; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase, Mitochondrial; Animals; Carbon Tetrachl | 2019 |
Resolution of Murine Toxic Hepatic Injury Quantified With Ultrasound Entropy Metrics.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Entro | 2019 |
A critical role of autophagy in regulating the mesenchymal transition of ductular cells in liver cirrhosis.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Carbon Tetrachloride; Disease Models, Animal; Epithelial- | 2019 |
Native T1 mapping compared to ultrasound elastography for staging and monitoring liver fibrosis: an animal study of repeatability, reproducibility, and accuracy.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Elasticity Imaging Techniques; Humans; Liver; | 2020 |
MSC-triggered metabolomic alterations in liver-resident immune cells isolated from CCl
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Tetrachloride; Cell Separation; Cells, Cultured; Chem | 2019 |
Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study.
Topics: Amylases; Animals; Antioxidants; Asteraceae; Blood Glucose; Carbon Tetrachloride; Chemical and Drug | 2015 |
Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies.
Topics: Abelmoschus; Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Chemical and Drug Induce | 2013 |
Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies.
Topics: Acetophenones; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Cells, Cult | 2013 |
Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Collagen; Dependovirus; Disease Models, Animal; E | 2013 |
Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blotting, Western; Body Weight | 2013 |
Marrow-derived mesenchymal stem cells restore biochemical markers of acute liver injury in experimental model.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Bone M | 2013 |
Hepatoprotection of 1β-hydroxyeuscaphic acid - the major constituent from Rubus aleaefolius against CCl4-induced injury in hepatocytes cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Disease Models, Animal; Dose-Response Relations | 2013 |
Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression.
Topics: Animals; Carbon Tetrachloride; Cell Count; Chemokine CCL5; Cytokines; Disease Models, Animal; Liver; | 2013 |
Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat.
Topics: Acetylcysteine; Allium; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis; Male | 2013 |
Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4 -injured rat liver model via increased autophagic mechanism.
Topics: Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cell Differentiation; Cell Growth Processes; Ch | 2013 |
A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Anim | 2013 |
Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hemodynamics; Ligation; Liver Cir | 2013 |
Association of age-dependent liver injury and fibrosis with immune cell populations.
Topics: Age Factors; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced L | 2013 |
Jaggery protects hepatorenal injury induced by acute exposure to carbon tetrachloride in Wistar rats.
Topics: Acute Kidney Injury; Adenosine Triphosphatases; Administration, Oral; Animals; Carbon Tetrachloride; | 2013 |
Antioxidant, hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication.
Topics: Alanine Transaminase; Animals; Antidotes; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carb | 2013 |
[Studying of hepatoprotective properties of dry extract from apricot leaves on the model of liver lesion by tetrachloromethane].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injur | 2013 |
Autologous bone marrow stem cell transplantation attenuates hepatocyte apoptosis in a rat model of ex vivo liver resection and liver autotransplantation.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Disease Mode | 2013 |
Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Molecular MRI of collagen to diagnose and stage liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disease Progression; Gadolin | 2013 |
Role of activin A in carbon tetrachloride-induced acute liver injury.
Topics: Activins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 2013 |
Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathway.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Caspase | 2013 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced chronic injury in rats.
Topics: Alanine Transaminase; Animals; Aprotinin; Aspartate Aminotransferases; Carbon Tetrachloride; Chemica | 2013 |
Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats.
Topics: Actins; Animals; beta Catenin; Biomarkers; Carbon Tetrachloride; Collagen Type I; Collagen Type III; | 2013 |
Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
Topics: Acute Disease; Alanine Transaminase; Animals; Antrodia; Aspartate Aminotransferases; Carbon Tetrachl | 2013 |
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Desmin; Disease Models, Animal; Glial Fibril | 2014 |
Hepatoprotective action of Orthosiphon diffusus (Benth.) methanol active fraction through antioxidant mechanisms: an in vivo and in vitro evaluation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; | 2013 |
[Protective effect of Tanreqing injection on acute hepatic injury induced by CCl4 in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Tetrachloride; Chemical and Dru | 2013 |
Study of the hepatoprotective effect of Juniperus phoenicea constituents.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; D | 2013 |
A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL1; Disease Mode | 2014 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Effect of collagen I gel on apoptosis of rat hepatic stellate cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Culture Techniques; Collagen Type I; Cycloheximide; C | 2013 |
Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Model | 2014 |
Therapeutic effects of hepatocyte growth factor-overexpressing human umbilical cord blood-derived mesenchymal stem cells on liver fibrosis in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2014 |
[Effect of shuganjianpifang on the expression of BCL-2 and BAX in rats livers with hepatic fibrosis].
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; C | 2013 |
Protective effect of selected calcium channel blockers and prednisolone, a phospholipase-A2 inhibitor, against gentamicin and carbon tetrachloride-induced nephrotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Calcium Channel Blockers; Carbon Tetrachloride; Cytoprotection; D | 2014 |
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas | 2014 |
Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; CD11b Antigen; Cell Line, Tumor; Cell Move | 2014 |
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.
Topics: Acute Disease; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Ch | 2014 |
Microbiome composition by pyrosequencing in mesenteric lymph nodes of rats with CCl4-induced cirrhosis.
Topics: Animals; Bifidobacterium; Biodiversity; Carbon Tetrachloride; Cells, Cultured; Disease Models, Anima | 2014 |
The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Carnitine; Chemical and Drug Induced Liver Injury; Di | 2013 |
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.
Topics: Animals; Calgranulin A; Calgranulin B; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2014 |
Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; | 2014 |
Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2014 |
Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cationic Amino Acid Transporter 1; CCAAT-Enhancer-Binding Protein-alp | 2014 |
[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Colchicine; Cytokines; Disease Models, Animal; Gene Expression Regula | 2013 |
[Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Carbon Tetrachloride; C | 2013 |
[Protective effect of purple sweet potato flavonoids on CCL4-induced acute liver injury in mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flavo | 2013 |
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Disease Model | 2013 |
Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Fe | 2014 |
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Tetrachloride; Cell Diffe | 2014 |
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.
Topics: Animals; Aptamers, Nucleotide; Carbon Tetrachloride; Chemokine CCL2; Disease Models, Animal; Disease | 2014 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Dr | 2014 |
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Topics: Angiotensin II; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; D | 2014 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Movement; Disease Models, Animal; Fibrosis; F | 2014 |
The biliary epithelium gives rise to liver progenitor cells.
Topics: Acetaminophen; Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, | 2014 |
High-mobility group box 1 exacerbates CCl₄-induced acute liver injury in mice.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Carbon Tetrachloride; Chemical and Drug Induc | 2014 |
VSL#3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Ascites; Bacterial Translocation; Carbon Tetrachloride; Disease Models, Animal; Intestinal | 2015 |
Pathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fatty Acids, Unsaturated; Hydroxy A | 2014 |
Effects of fish oil on cell proliferation and liver injury in an experimental model of acute hepatic injury induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injur | 2014 |
Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2014 |
MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Expressi | 2014 |
Determination of DNA damage in experimental liver intoxication and role of N-acetyl cysteine.
Topics: Acetylation; Acetylcysteine; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2014 |
Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro.
Topics: Actins; Animals; Benzopyrans; Butyrates; Carbon Tetrachloride; Cell Line; Collagen Type I; Disease M | 2014 |
The hepatocyte phase of Gd-EOB-DTPA-enhanced MRI in the evaluation of hepatic fibrosis and early liver cirrhosis in a rat model: an experimental study.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Contrast Media; Disease Models, Animal; Gadolin | 2014 |
Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fast Foods; Female; Gene Expression Profiling | 2014 |
Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Chemical and Dr | 2014 |
The effects of grape seed and colchicine on carbon tetrachloride induced hepatic damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Colchicine; Dis | 2014 |
The protective effect of Phoenix dactylifera L. seeds against CCl4-induced hepatotoxicity in rats.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2014 |
Effect of experimentally induced hepatic and renal failure on the pharmacokinetics of topiramate in rats.
Topics: Animals; Anti-Obesity Agents; Antineoplastic Agents; Carbon Tetrachloride; Carbon Tetrachloride Pois | 2014 |
Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice.
Topics: Alanine Transaminase; Amniotic Fluid; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Di | 2014 |
Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Cell Transplantation; Disease Models | 2014 |
Origin of myofibroblasts in the fibrotic liver in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen Type I; | 2014 |
[Metabonomic study on protective effect of xiaoyao powder for acute hepatic injury in rats].
Topics: Amino Acids; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2014 |
Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Collagen Type I; Connective Tissue Growth Factor; Di | 2014 |
BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor.
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Disease Models, Anim | 2014 |
Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Dipeptidyl Peptidase 4; Disease Models, Animal; D | 2014 |
Prevention of carbon tetrachloride (CCl4)-induced toxicity in testes of rats treated with Physalis peruviana L. fruit.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Catalase; Disease Models, Animal; Fruit; Fruit and Vegetab | 2016 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Connective Tissue Growth Factor; Dis | 2014 |
Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Dru | 2014 |
Prevention of liver fibrosis by intrasplenic injection of high-density cultured bone marrow cells in a rat chronic liver injury model.
Topics: Animals; Blood Vessels; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell C | 2014 |
Hepato- and nephroprotective activities of a Nigerian local king tuber oyster mushroom, Pleurotus tuberregium (higher Basidiomycetes), in chemically induced organ toxicities in rats.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Complex Mixtures; Disease Model | 2014 |
Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice.
Topics: Actins; Adiponectin; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Collagen; Disease | 2014 |
In vitro antioxidant and in vivo hepatoprotective activity of leave extract of Raphanus sativus in rats using CCL4 model.
Topics: Alanine Transaminase; Aldehydes; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachl | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
Carbon tetrachloride-induced kidney damage and protective effect of Amaranthus lividus L. in rats.
Topics: Amaranthus; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Disease Models, Animal; Glutathio | 2016 |
Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.
Topics: Animals; Aryldialkylphosphatase; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2014 |
Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Carbon Tetrachloride; Cell Move | 2015 |
Portal blood arterialization with an extracorporeal device to treat toxic acute hepatic failure in a swine model.
Topics: Animals; Biomarkers; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease M | 2014 |
Pharmacological Potential of Tetrahydrofurano/Pyrano Quinoline and Benzo[b]furoindolyl Derivatives in Acute Inflammation, Pain and Oxidative Stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzofurans; Carbon Tetrachloride; Carr | 2015 |
Systemic treatment of acute liver failure with adipose derived stem cells.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Ce | 2015 |
Role of Fn14 in acute alcoholic steatohepatitis in mice.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; | 2015 |
Mesenteric and splenic contributions to portal venous CT perfusion in hepatic diffuse disease.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dogs; Hepatitis, Animal; Liver Cirrhosis; Mes | 2014 |
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Caspase 12; Caspase 3; Caspase 9; Chemical and | 2014 |
Histamine restores biliary mass following carbon tetrachloride-induced damage in a cholestatic rat model.
Topics: Animals; Apoptosis; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Cell Proliferation; | 2015 |
Mouse models of liver cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Evaluation of the effectiveness of Piper cubeba extract in the amelioration of CCl4-induced liver injuries and oxidative damage in the rodent model.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2015 |
Bifidobacterium pseudocatenulatum CECT7765 promotes a TLR2-dependent anti-inflammatory response in intestinal lymphocytes from mice with cirrhosis.
Topics: Animals; Bifidobacterium; Carbon Tetrachloride; Disease Models, Animal; Female; Gastrointestinal Mic | 2016 |
Inhibitory effect of dietary capsaicin on liver fibrosis in mice.
Topics: Animals; Bile Ducts; Capsaicin; Carbon Tetrachloride; Cholestasis; Diet; Disease Models, Animal; Dow | 2015 |
Hyperbaric oxygen treatment at various stages following chronic constriction injury produces different antinociceptive effects via regulation of P2X4R expression and apoptosis.
Topics: Analgesics; Animals; Apoptosis; Behavior, Animal; Carbon Tetrachloride; Caspase 3; Constriction; Dis | 2015 |
The carbon tetrachloride model in mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; European Union; Guidelines as Topic; Humans; | 2015 |
Optical diagnosis of the progression and reversal of CCl4-induced liver injury in rodent model using minimally invasive autofluorescence spectroscopy.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disea | 2015 |
Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota).
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induc | 2015 |
Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Carbon Tetrachloride; CD11b Antigen; Chemical and Drug Induced Liver Injury; Disease Models | 2015 |
Effect of CCl4 and blocking H2S biosynthesis on oesophageal mucosa rats: model of nonerosive oesophagitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Disease Models, Animal; Enzy | 2014 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
Deceleration of liver regeneration by knockdown of augmenter of liver regeneration gene is associated with impairment of mitochondrial DNA synthesis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Carbon tetrachloride-induced liver injury in mice is tissue factor dependent.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA, | 2015 |
Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Proliferation; | 2015 |
Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Caspase Inhibitors; Cell Prolif | 2015 |
Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cholestasis; Disease Models, Animal; Humans; Ligation; Li | 2016 |
Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.
Topics: Alcohol Dehydrogenase; Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; | 2015 |
Effects of polysaccharides from selenium-enriched Pyracantha fortuneana on mice liver injury.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, | 2016 |
Macrophage autophagy protects against liver fibrosis in mice.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cell Lineage; Culture Media, | 2015 |
Cyanidin-3-O-β-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Glucosides; Hepatic | 2015 |
Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo.
Topics: Animals; Antioxidants; Benzofurans; Carbon Tetrachloride; Cell Line; Depsides; Disease Models, Anima | 2015 |
Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis.
Topics: Adipose Tissue; Animals; Biomarkers; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; | 2015 |
Effects of Pistacia Atlantica Extract on Erythrocyte Membrane Rigidity, Oxidative Stress, and Hepatotoxicity Induced by CCl4 in Rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Disea | 2015 |
Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; | 2015 |
Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dioxoles; Disea | 2015 |
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4‑induced fibrosis in mice.
Topics: Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2015 |
N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced L | 2015 |
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Carbon Te | 2016 |
Effect of flavonoid compounds extracted from Iris species in prevention of carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Flavonoids; Iris Plant; Liver; Liver Cirrhosi | 2015 |
Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2015 |
Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2016 |
Hepatoprotective effects of polysaccharide isolated from Agaricus bisporus industrial wastewater against CCl₄-induced hepatic injury in mice.
Topics: Agaricus; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 2016 |
Transplantation of mesenchymal stem cells expressing TIMP-1-shRNA improves hepatic fibrosis in CCl₄-treated rats.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Genetic Therapy; Genetic V | 2015 |
Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Fun | 2015 |
Protective Effect of Zingiber Officinale against CCl4-Induced Liver Fibrosis Is Mediated through Downregulating the TGF-β1/Smad3 and NF-ĸB/IĸB Pathways.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regula | 2016 |
A model of acute kidney injury in mice with cirrhosis and infection.
Topics: Acute Kidney Injury; Animals; Carbon Tetrachloride; Creatinine; Disease Models, Animal; Echocardiogr | 2016 |
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; | 2016 |
Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Movement; Chemok | 2015 |
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Case-Control Studies; C | 2016 |
Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Regulation; Liver; Liver Cirr | 2016 |
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2015 |
Resveratrol can prevent CCl₄-induced liver injury by inhibiting Notch signaling pathway.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2016 |
D-Pinitol Protects Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2015 |
The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2016 |
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.
Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; Ge | 2016 |
Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis.
Topics: Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Disease Models, Animal; Enzyme-Linked Imm | 2016 |
Rebamipide retards CCl4-induced hepatic fibrosis in rats: Possible role for PGE2.
Topics: Alanine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbo | 2016 |
Therapeutic Effect of Losartan, an Angiotensin II Type 1 Receptor Antagonist, on CCl₄-Induced Skeletal Muscle Injury.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Carbon Tetrachloride; Disease Models, | 2016 |
Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrho | 2016 |
Autophagy-Modulated Human Bone Marrow-Derived Mesenchymal Stem Cells Accelerate Liver Restoration in Mouse Models of Acute Liver Failure.
Topics: Animals; Autophagy; Autophagy-Related Protein 7; Bone Marrow Cells; Carbon Tetrachloride; Cell Diffe | 2016 |
Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Proliferation; Chemokine CCL2; Chemokine CCL5; Chole | 2016 |
4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study.
Topics: Animals; Apolipoproteins B; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Disease Models, Animal; D | 2016 |
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice.
Topics: Aminoquinolines; Animals; Benzimidazoles; Bleomycin; Butylamines; Carbon Tetrachloride; Chemokine CX | 2016 |
The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Cytogl | 2016 |
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ₃ for staging liver fibrosis in rat model.
Topics: Animals; Carbon Tetrachloride; Dextrans; Disease Models, Animal; Hepatic Stellate Cells; Integrin al | 2016 |
MicroRNA-125a-5p Contributes to Hepatic Stellate Cell Activation through Targeting FIH1.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Disease | 2016 |
Protective effects of L-carnosine on CCl4 -induced hepatic injury in rats.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury | 2016 |
Dual-Functional Nanoparticles Targeting CXCR4 and Delivering Antiangiogenic siRNA Ameliorate Liver Fibrosis.
Topics: Angiogenesis Inhibitors; Animals; Benzylamines; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cyc | 2016 |
Metabolic Profile Changes of CCl₄-Liver Fibrosis and Inhibitory Effects of Jiaqi Ganxian Granule.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chromatography, Liquid; Disease Models, Animal; Drugs, Ch | 2016 |
Effects of platelet-rich plasma on liver regeneration in CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Connective Tissue; Disease Mo | 2016 |
Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury.
Topics: Animals; Autocrine Communication; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2016 |
Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride-mediated oxidative hepatocellular damage in rat model.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curc | 2016 |
Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Culture Media, Conditioned; Dental Pulp; Disease Models, Animal; Fema | 2016 |
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Communication; Coculture Techniques; Cytokines; Dise | 2016 |
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Carrier Proteins; Cholesterol; Disease Models, Ani | 2016 |
Pharmacological safety evaluation of a traditional herbal medicine "Zereshk-e-Saghir" and assessment of its hepatoprotective effects on carbon tetrachloride induced hepatic damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Berb | 2016 |
Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Ly; Carbon Tetrachloride; Chemokine CCL2 | 2016 |
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Collagen; Collagen Type I; Collagen Type I, | 2016 |
Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Carbon Tetrachloride; Cell Survival; C | 2016 |
Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
Topics: Actins; Animals; Antigens, CD; Blotting, Western; Cadherins; Carbon Tetrachloride; Cdh1 Proteins; Ce | 2017 |
Gadoxetate-enhanced MR imaging and compartmental modelling to assess hepatocyte bidirectional transport function in rats with advanced liver fibrosis.
Topics: Animals; Bile Ducts, Intrahepatic; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Contrast | 2017 |
Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hepatic Stellate Cells; | 2016 |
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2016 |
mTOR Overactivation in Mesenchymal cells Aggravates CCl
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Deletion; Liver; Liver Cirrhosis; Mice; | 2016 |
Cystathionine γ-Lyase Deficiency Exacerbates CCl
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2017 |
miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Regulation; Hepatocytes; Huma | 2016 |
The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill.
Topics: Administration, Oral; Alanine Transaminase; Animals; Biomarkers; Body Weight; Carbon Tetrachloride; | 2017 |
Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.
Topics: Animals; Automation, Laboratory; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hydroxypr | 2017 |
Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil.
Topics: Allyl Compounds; Animals; Antioxidants; Brain; Brassica; Carbon Tetrachloride; Chemical and Drug Ind | 2017 |
Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation.
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Fruit; Heme Oxygenase-1; Interleuk | 2017 |
Mesenchymal Stem Cells with Enhanced Bcl-2 Expression Promote Liver Recovery in a Rat Model of Hepatic Cirrhosis.
Topics: Animals; Antigens; Biomarkers; Carbon Tetrachloride; Cell Shape; Disease Models, Animal; Gene Expres | 2016 |
The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice.
Topics: Animals; Antifibrinolytic Agents; Becaplermin; Carbon Tetrachloride; Cell Movement; Collagen Type I; | 2017 |
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Topics: Animals; Benzoquinones; Carbon Tetrachloride; Disease Models, Animal; Hedgehog Proteins; Hepatic Ste | 2017 |
Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice.
Topics: Animals; Autophagy; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2017 |
Optimized Mouse Models for Liver Fibrosis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2017 |
Systematic quantification of histological patterns shows accuracy in reflecting cirrhotic remodeling.
Topics: Algorithms; Animals; Carbon Tetrachloride; Diagnostic Imaging; Disease Models, Animal; Disease Progr | 2017 |
Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matri | 2017 |
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Topics: Adenosine; Animals; Biomarkers; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Disea | 2017 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
Anti-TGFβ-1 receptor inhibitor mediates the efficacy of the human umbilical cord mesenchymal stem cells against liver fibrosis through TGFβ-1/Smad pathway.
Topics: Animals; Benzamides; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cultured; Combi | 2017 |
Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model.
Topics: Acute-On-Chronic Liver Failure; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon T | 2017 |
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.
Topics: 3T3-L1 Cells; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Biomarkers; Carbon Tetrachlorid | 2017 |
Study on the effects of blueberry treatment on histone acetylation modification of CCl
Topics: Acetylation; Animals; Aspartate Aminotransferases; Blueberry Plants; Carbon Tetrachloride; Disease M | 2017 |
C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice.
Topics: Adaptation, Physiological; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2017 |
Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Disease Models, Animal; Humans; Indoles; Inflammation; Liv | 2017 |
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells | 2008 |
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type IV; | 2008 |
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Cell Transdifferentiation; Cells | 2008 |
Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug In | 2008 |
Platelets contribute to the reduction of liver fibrosis in mice.
Topics: Animals; Blood Platelets; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Female; | 2009 |
Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure.
Topics: Adult; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetra | 2009 |
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.
Topics: Amphiregulin; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cells, Cultured; Disease Models, | 2008 |
Red wine polyphenols affect the collagen composition in the aorta after oxidative damage induced by chronic administration of CCl(4).
Topics: Animals; Aorta; Aortic Diseases; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Disease M | 2009 |
Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents.
Topics: Acute Disease; Alanine; Ammonia; Animals; Carbon Tetrachloride; Chronic Disease; Disease Models, Ani | 2008 |
Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Disease Models, Animal; Endoplasmic Reticulum; Hepatocy | 2008 |
Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type | 2008 |
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Line; Concanavalin A; Cytokines; Disease M | 2008 |
The hepatic apelin system: a new therapeutic target for liver disease.
Topics: Adult; Animals; Apelin; Blood Pressure; Carbon Tetrachloride; Carrier Proteins; Case-Control Studies | 2008 |
Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation.
Topics: Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Live | 2009 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
[Comparison of two rat models of IgA nephropathy].
Topics: Animals; Bacterial Toxins; Carbon Tetrachloride; Disease Models, Animal; Female; Glomerulonephritis, | 2008 |
Development of a new animal model of liver cirrhosis in swine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl(4)-induced acute liver failure.
Topics: Administration, Oral; Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Caspases; Chemistry, P | 2009 |
Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and | 2008 |
Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Culture Techniques; Cell Lineage; Cell Transdifferenti | 2009 |
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Prolifer | 2009 |
Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatectomy; Liver Cirrhosis, Experimental; M | 2008 |
Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis.
Topics: Albumins; Animals; Azo Compounds; Bone Marrow Transplantation; Carbon Tetrachloride; Central Nervous | 2008 |
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Disease Models, Animal; Hepato | 2009 |
Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Co | 2009 |
[Effect of aspartame on the liver cirrhosis model induced by the complex factors].
Topics: Animals; Aspartame; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Liver; Liver Cirrhosis, E | 2009 |
Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats.
Topics: Animals; Animals, Suckling; Blood Chemical Analysis; Blotting, Western; Carbon Tetrachloride; Carbon | 2009 |
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemokine CXCL9; Cohort Studies; Collagen; Disease M | 2009 |
Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aryldialkylphosphatase; Aspartate Aminotransferases; Carbon Tetrachlo | 2009 |
A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Carboxypeptidase B2; Cell Division; Cells, Cultured; C | 2009 |
Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication.
Topics: Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Blood Urea Nitrogen; Brai | 2009 |
The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Differentiati | 2009 |
Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Live | 2009 |
Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2009 |
Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.
Topics: Animals; Carbon Tetrachloride; cdc42 GTP-Binding Protein; Cell Proliferation; Chemical and Drug Indu | 2009 |
Overexpression of beta-catenin is responsible for the development of portal hypertension during liver cirrhosis.
Topics: Adenoviridae; Animals; beta Catenin; Carbon Tetrachloride; Disease Models, Animal; Disease Progressi | 2009 |
Suppression of carbon tetrachloride-induced liver fibrosis by transplantation of a clonal mesenchymal stem cell line derived from rat bone marrow.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line, Tumor; | 2009 |
[Establishment of liver fibrosis in rabbit model and quantitative study on hepatic perfusion with dynamic whole-liver 3D MR imaging].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Image Interpretation, Computer-Assisted; Imag | 2009 |
[Effects of transforming growth factor beta 3 on the histopathology and expression of collagen I in experimental hepatic fibrotic rats].
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Dependovirus; Disease Models, Animal; Genetic Therap | 2009 |
Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Annonaceae; Aspartate | 2009 |
[Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponectin-free fatty acid pathway].
Topics: Adiponectin; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; | 2009 |
Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Liver Cirrhosis; Male; Panax notog | 2009 |
Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Carbon Tetra | 2009 |
Carbon tetrachloride-induced liver disease in rats: the potential effect of supplement oils with vitamins E and C on the nutritional status.
Topics: Animals; Ascorbic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Dieta | 2009 |
Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Asteraceae; Blood Proteins; Carbon Tetra | 2009 |
The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Male; Plant Extracts; | 2009 |
Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Mode | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Transdifferentiation; Disease Models, Anim | 2010 |
A novel model of CCl4-induced cirrhosis with ascites in the mouse.
Topics: Administration, Inhalation; Animals; Ascites; Carbon Tetrachloride; Cytokines; Disease Models, Anima | 2009 |
Modification of sleep architecture in an animal model of experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Disease Progression; Dose-Response Relationsh | 2009 |
Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis.
Topics: Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Cell Line, Transformed; Disease Models, Anima | 2010 |
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatocytes; Intercellular S | 2010 |
[Comparative morphofunctional analysis of rat hepatocyte cultures isolated from the normal and pathologically changed liver due to experimental toxic hepatitis].
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury, Chronic; Dis | 2009 |
[The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver].
Topics: Adiponectin; Animals; Carbon Tetrachloride; Dietary Fats; Disease Models, Animal; Drug Combinations; | 2009 |
Garlic extract prevents CCl(4)-induced liver fibrosis in rats: The role of tissue transglutaminase.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Cystamine; Disease Models, Animal; Down-Regulation; | 2010 |
Multipotent progenitor cells derived from human umbilical cord blood can differentiate into hepatocyte-like cells in a liver injury rat model.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Disease Models, Animal; Fetal Blood; Hematopoie | 2009 |
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2010 |
Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2010 |
Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists.
Topics: Analgesics; Animals; Antioxidants; Carbon Tetrachloride; Cimetidine; Disease Models, Animal; Dose-Re | 2011 |
Taohe Chengqi Tang ameliorates acute liver injury induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2010 |
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell | 2010 |
Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats.
Topics: Animals; Ascites; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Fatty Liver; Female; Liver | 2010 |
Effect of purified saponin mixture from Astragalus corniculatus on enzyme- and non-enzyme-induced lipid peroxidation in liver microsomes from spontaneously hypertensive rats and normotensive rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Astragalus Plant; Carbon Tetrachloride; Disease Models, Animal | 2010 |
Granulocyte colony-stimulating factor enhances bone marrow mononuclear cell homing to the liver in a mouse model of acute hepatic injury.
Topics: Albumins; Animals; Biopsy; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cel | 2010 |
Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers.
Topics: Androgens; Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; | 2010 |
Therapeutic effect of transplanting beta(2)m(-)/Thy1(+) bone marrow-derived hepatocyte stem cells transduced with lentiviral-mediated HGF gene into CCl(4)-injured rats.
Topics: Animals; beta 2-Microglobulin; Bone Marrow; Carbon Tetrachloride; Disease Models, Animal; Female; Ge | 2010 |
Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrach | 2010 |
TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon | 2010 |
Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression.
Topics: Actins; Animals; Bone Marrow Cells; Carbon Tetrachloride; Collagen; Disease Models, Animal; Down-Reg | 2010 |
Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells on nanofibers and their transplantation into a carbon tetrachloride-induced liver fibrosis model.
Topics: Animals; Biomarkers; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; | 2011 |
[Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Liver Cirrhosis, Experimenta | 2010 |
Effects of Haobie Yangyin Ruanjian decoction on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Blotting, Western; Carbon Te | 2010 |
Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Proliferatio | 2010 |
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Chemical and Dru | 2010 |
[The approaches for making acute-on-chronic liver failure in rat].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Disease Models, Animal; Galactosamine; Humans; | 2009 |
Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via a tumor necrosis factor-alpha-dependent mechanism.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Inter | 2010 |
[Observation on experimental liver fibrosis and hepatic carcinogenesis of HBV gene knock-in transgenic mice induced by CCl4/ethanol].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Gene Knock-In Techniques; He | 2010 |
Rat CCl(4)-induced cirrhosis plus total portal vein ligation: a new model for the study of hyperammonaemia and brain oedema.
Topics: Animals; Ascites; Biomarkers; Brain; Brain Edema; Carbon Tetrachloride; Disease Models, Animal; Endo | 2010 |
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachlo | 2010 |
Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Topics: Animals; Bile Ducts; Biomarkers; Calcium-Binding Proteins; Carbon Tetrachloride; Cell Lineage; Cell | 2010 |
Enhanced effect of soluble transforming growth factor-beta receptor II and IFN-gamma fusion protein in reversing hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; DNA Primers; Gene Amplification; Interferon-g | 2010 |
Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Hepatic Ste | 2010 |
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Collagen Type I; Disease Models, Animal; | 2010 |
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cannabinoids; Carbon Tetrachl | 2010 |
Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.
Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Carbon Tet | 2010 |
Bone marrow cells reduce fibrogenesis and enhance regeneration in fibrotic rat liver.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Cells, Cultured; C | 2011 |
Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Early Growth Response Protein 1; Female; Gene | 2010 |
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor.
Topics: AC133 Antigen; Amphiregulin; Animals; Antigens, CD; Carbon Tetrachloride; Cell Differentiation; Desm | 2010 |
Hepatoprotective activities of two Ethiopian medicinal plants.
Topics: Acanthaceae; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2010 |
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2010 |
Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch. et Sav.) Ching.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose- | 2010 |
Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship | 2011 |
Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2010 |
Protective effects of Pergularia daemia roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemi | 2010 |
The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease Models, | 2010 |
Immune modulation of ovalbumin-induced lung injury in mice using β-glucosylceramide and a potential role of the liver.
Topics: Allergens; Animals; Asthma; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Cell Proliferation; Ce | 2011 |
Antioxidant effects of Citharexylum spinosum in CCl₄ induced nephrotoxicity in rat.
Topics: Animals; Antioxidants; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning | 2012 |
MRI of magnetically labeled mesenchymal stem cells in hepatic failure model.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Contrast Media; Dextrans; Disease Mod | 2010 |
Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity.
Topics: Amino Acids; Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Chemical and Drug Induce | 2011 |
Protective effect of Sonchus asper extracts against experimentally induced lung injuries in rats: a novel study.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; DNA Damage; Lipid Peroxidation; | 2012 |
Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced L | 2011 |
Evaluation of the antioxidant and hepatoprotective effect of Majoon-e-Dabeed-ul-ward against carbon tetrachloride induced liver injury.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2012 |
Anti-inflammatory properties of Ajuga bracteosa in vivo and in vitro study and their effects on mouse model of liver fibrosis.
Topics: Ajuga; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
Early growth response (EGR)-1 is required for timely cell-cycle entry and progression in hepatocytes after acute carbon tetrachloride exposure in mice.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injur | 2011 |
Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function.
Topics: Animals; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Chemokines; Cytokine TWEAK; Disease M | 2011 |
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
Protective effect of chrysin on carbon tetrachloride (CCl4)-induced tissue injury in male Wistar rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2011 |
Inflammation does not always kill hepatocytes during liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2011 |
Pre-existing liver cirrhosis reduced the toxic effect of diethylene glycol in a rat model due to the impaired hepatic alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Animals; Carbon Tetrachloride; Disease Models, Animal; Ethylene Glycols; Hepa | 2011 |
Effects and mechanisms of Acremoniumterricola milleretal mycelium on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Acremonium; Animals; Antioxidants; Biological Products; Carbon Tetrachloride; Disease Models, Animal | 2011 |
Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2011 |
Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; China; Curcuma; Disease Models, Anima | 2011 |
The roles of ER stress and P450 2E1 in CCl(4)-induced steatosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Disease Models, Animal; Endopl | 2011 |
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
Topics: Angiotensin II; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium; Calcium Channel Blockers; | 2012 |
Effects of Shugan-Huayu powder, a traditional Chinese medicine, on hepatic fibrosis in rat model.
Topics: Actins; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; | 2010 |
Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta.
Topics: ADAM Proteins; ADAMTS1 Protein; Aged; Amino Acid Motifs; Animals; Carbon Tetrachloride; Collagen Typ | 2011 |
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Blood Glucose; Brain; Brain Chemistry; Car | 2011 |
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2011 |
Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Disea | 2011 |
A novel fluorinated stilbene exerts hepatoprotective properties in CCl(4)-induced acute liver damage.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cho | 2011 |
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Topics: Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Cholesterol, Dietary; Disease Models, Animal; | 2012 |
Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced rat hepatic injury.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachlor | 2011 |
Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography; C | 2011 |
Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2011 |
Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Disease Models, Animal; Embryonic St | 2013 |
CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
Topics: Animals; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; C | 2012 |
Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Calori | 2012 |
Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Fibrosis; Humans; Interleuki | 2011 |
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.
Topics: Animals; Bacterial Translocation; Bacteroides fragilis; beta-Defensins; Bifidobacterium; Carbon Tetr | 2012 |
Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cell Transplantation; Cells, Cult | 2012 |
Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen; Cytokines; Disease Mod | 2012 |
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cathepsin B; Cathepsin D; | 2012 |
Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis.
Topics: Animals; Benzaldehydes; Blotting, Western; Carbon Tetrachloride; Catechols; Cell Proliferation; Cell | 2012 |
Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Cell Separation | 2012 |
Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemica | 2012 |
Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver.
Topics: Animals; Apoptosis; Binding Sites; Carbon Tetrachloride; Caspase 3; Caspase 7; Cell Proliferation; C | 2012 |
Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl(4)-induced advanced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular M | 2012 |
Effects of manual acupuncture at GB34 on carbon tetrachloride-induced acute liver injury in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 2011 |
Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbon Tetrachloride; C | 2012 |
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2012 |
Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyperus | 2012 |
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Bromodeoxyuridine; Carbon Tetrachloride; Cell Pr | 2012 |
PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Cyclooxygenase 1; Disease Models, Animal; Endothelium | 2012 |
Augmenter of liver regeneration may be a candidate for prognosis of HBV related acute-on-chronic liver failure as a regenerative marker.
Topics: Analysis of Variance; Animals; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Chemical and | 2012 |
Ex vivo-expanded bone marrow stem cells home to the liver and ameliorate functional recovery in a mouse model of acute hepatic injury.
Topics: Acute Disease; Alanine Transaminase; Albumins; Animals; Aspartate Aminotransferases; Biomarkers; Bon | 2012 |
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Indu | 2012 |
Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Disease Models, Animal; Fatty Liver; Female | 2012 |
Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Cholestasis; Disease Models, Animal; Intesti | 2012 |
[Dynamic expression of TGF-beta1/Smad protein in CCl4-induced liver fibrosis and its significance in rats].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Humans; Liver Cirrhosis; Male; Random Allocat | 2011 |
Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; | 2012 |
In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia.
Topics: Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chelating | 2012 |
Adenovirus-mediated dual gene expression of human interleukin-10 and hepatic growth factor exerts protective effect against CCl4-induced hepatocyte injury in rats.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury | 2012 |
Expression patterns of heat shock protein 25 in carbon tetrachloride-induced rat liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Data Interpretatio | 2013 |
Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Differentiation; Cell Survival; Cell- and Tissue-B | 2012 |
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Dis | 2011 |
Impairment of α(2)-macroglobulin synthesis in experimental hepatopathic rats treated with turpentine oil.
Topics: Acetaminophen; Acute Disease; alpha-Macroglobulins; Analgesics, Non-Narcotic; Animals; Carbon Tetrac | 2012 |
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Hepa | 2012 |
Gadolinium accumulation and fibrosis in the liver after administration of gadoxetate disodium in a rat model of active hepatic fibrosis.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Disease Models, Animal; Gadolinium DTPA; Liver | 2012 |
Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CCL5; Disease Model | 2012 |
[Inhibitory effect of acupuncture on hepatic extracellular matrix production in carbon tetrachloride-induced liver fibrosis rats].
Topics: Acupuncture Therapy; Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Extrace | 2012 |
Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats.
Topics: Animals; Antiparkinson Agents; Bile Ducts; Blood Pressure; Carbidopa; Carbon Tetrachloride; Disease | 2012 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models, | 2012 |
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
Topics: Animals; Apoptosis; Carbon Tetrachloride; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase | 2012 |
Fibroblast growth factor 7 inhibits cholesterol 7α-hydroxylase gene expression in hepatocytes.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Cell Line, Tumor; Cholesterol 7-alpha-Hydroxyla | 2012 |
Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis.
Topics: Amnion; Animals; Antibody Formation; Carbon Tetrachloride; Cell Transplantation; Disease Models, Ani | 2012 |
Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransf | 2012 |
Protective role of antithrombin in mouse models of liver injury.
Topics: Animals; Antithrombins; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2012 |
Protective effects of Moutan Cortex Radicis against acute hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Bilirubin; Carbon Tetrachloride; Chemical a | 2011 |
Mesenteric arteries responsiveness to acute variations of wall shear stress is impaired in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; | 2012 |
Adenoviral dominant-negative soluble PDGFRβ improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats.
Topics: Actins; Adenoviridae; Animals; beta-Galactosidase; Carbon Tetrachloride; Collagen; Disease Models, A | 2012 |
Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: an animal study.
Topics: Animals; Biopsy, Needle; Carbon Tetrachloride; Contrast Media; Disease Models, Animal; Image Enhance | 2012 |
Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora.
Topics: Animals; Antioxidants; Bilirubin; Biomarkers; Blood Urea Nitrogen; Carbon Tetrachloride; Chemical an | 2012 |
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.
Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2012 |
Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Apoptosis; Carbon Tetrachloride; Cell Survival; Cells, Cul | 2012 |
Protective effect of transplantation of neonatal liver cell nuclei on the model of acute toxic hepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Comparative study on the inhibitory effects of α-tocopherol and radon on carbon tetrachloride-induced renal damage.
Topics: Acute Kidney Injury; alpha-Tocopherol; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachlo | 2012 |
Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Liver Cirrhosis; Male; | 2013 |
Antioxidant and hepatoprotective activity of an ethanol extract of Syzygium jambos (L.) leaves.
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induc | 2012 |
Dysbalance in sympathetic neurotransmitter release and action in cirrhotic rats: impact of exogenous neuropeptide Y.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Electric Stimulation; Hypertension, Portal; L | 2013 |
Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids, Branched-Chain; Animals; Antioxidants; Biomarkers; Blottin | 2012 |
Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoantibodies; Carbon Tetrachlo | 2013 |
1H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4 administration.
Topics: Acute Lung Injury; Animals; Carbon Tetrachloride; Disease Models, Animal; Energy Metabolism; Folic A | 2013 |
Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liv | 2012 |
Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; ErbB Receptors; Female; Liver Cirrhosis; Male | 2013 |
Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats.
Topics: Acetylcholine; Animals; Carbon Tetrachloride; Disease Models, Animal; Endothelium, Vascular; Hypoxia | 2013 |
Radix Paeoniae Rubra and Radix Paeoniae Alba Attenuate CCl4-induced acute liver injury: an ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) based metabolomic approach for the pharmacodynamic study of Traditional Chinese Medicines (TCMs)
Topics: Animals; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2012 |
Hepatoprotective efficacy of Sharbat-e-Deenar against carbon tetrachloride-induced liver damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2012 |
[The anti-portal hypertension effect of oleanolic acid in CCl4-induced cirrhosis rats].
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Liver; Liv | 2012 |
Protective role of ferulic acid on carbon tetrachloride-induced hyperlipidemia and histological alterations in experimental rats.
Topics: Animals; Carbon Tetrachloride; Cholesterol; Coumaric Acids; Disease Models, Animal; Fatty Acids, Non | 2013 |
Hepatoprotective effect of herbal drug on CCl(4) induced liver damage.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Carbon Tetrachloride; Ch | 2013 |
Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Dru | 2013 |
Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 2012 |
Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts.
Topics: Animals; Antioxidants; Asparagus Plant; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug | 2012 |
Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Disease Models, Animal; Di | 2013 |
Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Curcumin; Disease Models, An | 2012 |
Magnetic resonance-based total liver volume and magnetic resonance-diffusion weighted imaging for staging liver fibrosis in mini-pigs.
Topics: Animals; Area Under Curve; Carbon Tetrachloride; Contrast Media; Diffusion; Diffusion Magnetic Reson | 2012 |
Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2013 |
Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Re | 2013 |
Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransfer | 2002 |
Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.
Topics: Abietanes; Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2002 |
Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver.
Topics: Albumins; Animals; Biological Transport; Carbon Radioisotopes; Carbon Tetrachloride; Cell Membrane; | 2002 |
A novel method for preparation of animal models of liver damage: liver targeting of carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Delivery Systems; Liver; Male; Rats; Rat | 2002 |
Enzyme release from injured, preserved, and ex vivo reperfused liver does not indicate malfunction.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2002 |
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
Iron overload enhances the development of experimental liver cirrhosis in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Iron Carbonyl Compounds; Iron Overl | 2003 |
[Study on hepatic-protective effect of "yinzhihuang" granula].
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Car | 2001 |
Quantitative diagnosis of fatty liver with dual-energy CT. An experimental study in rabbits.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fatty Liver; Female; Male; Rabbits; Reproduci | 2003 |
Hepatic osteodystrophy in rats results mainly from portasystemic shunting.
Topics: Absorptiometry, Photon; Animals; Bone Density; Carbon Tetrachloride; Disease Models, Animal; Female; | 2003 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2003 |
Renal effects of selective cyclooxygenase inhibition in experimental liver disease.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygen | 2003 |
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.
Topics: Acute Disease; Adolescent; Adult; Aged; Animals; Antigens, CD; Carbon Tetrachloride; Cell Division; | 2003 |
Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute?
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Line; Chimera; D | 2003 |
Effect of spleen on immune function of rats with liver cancer complicated by liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carcinoma 256, Walker; Disease Models, Animal; Killer Cells, Natural; | 2003 |
Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2004 |
Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2003 |
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
Effects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Interleukin | 2004 |
Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Collagen; Culture Media; Disease Models, Animal; Gene E | 2004 |
[Experimental study on iNOS gene transfer mediated by liposome to treat portal hypertension in cirrhotic rats].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Immunohistochemistry; L | 2004 |
Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Cross-Linking Reagents; Dipeptide | 2004 |
The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Carb | 2004 |
Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical | 2002 |
Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibroblast Growth Factor 7; | 2004 |
Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Cell Line; Cell Transformation, Neoplastic; Disease Model | 2005 |
Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Disease Models, Animal; Glucose; Glucose Transp | 2005 |
G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Lineage; Cell Mo | 2005 |
Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Epithelial Sodium Channels; Kidney; Liver Cir | 2005 |
Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Flavones; Hep | 2005 |
Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disea | 2005 |
Protective effect of fufanghuangqiduogan against acute liver injury in mice.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2005 |
[Peritoneal dialysis with allogenic hepatic cell suspension in treatment of hepatic insufficiency].
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Transplantation; Disease Models, Animal; Female; | 2005 |
Pharmacokinetics of verapamil and its major metabolite, norverapamil from oral administration of verapamil in rabbits with hepatic failure induced by carbon tetrachloride.
Topics: Administration, Oral; Animals; Biological Availability; Calcium Channel Blockers; Carbon Tetrachlori | 2005 |
Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats.
Topics: Acute Disease; Alanine Transaminase; Allyl Compounds; Animals; Aspartate Aminotransferases; Biphenyl | 2005 |
Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cinnamates; Disease Models, A | 2005 |
Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; | 2005 |
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fem | 2005 |
Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonate 5-Lipoxygenase; Carbon Tetrachloride; Carr | 2005 |
Modeling liver fibrosis in rodents.
Topics: Actins; Animals; Animals, Genetically Modified; Apoptosis; Azo Compounds; Carbon Tetrachloride; Colo | 2005 |
Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.
Topics: Animals; Biomarkers; Biopsy; Carbon Tetrachloride; Disease Models, Animal; Female; Fluorescent Antib | 2005 |
L-[1-13C] phenylalanine breath test results reflect the activity of phenylalanine hydroxylase in carbon tetrachloride acute injured rat liver.
Topics: Acute Disease; Animals; Breath Tests; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 2006 |
Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Gene Expressio | 2006 |
Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; | 2006 |
Differential gene expression profiles in the steatosis/fibrosis model of rat liver by chronic administration of carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2005 |
Complementary regulation of heme oxygenase-1 and peroxiredoxin I gene expression by oxidative stress in the liver.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Heme | 2005 |
[Comparing studies on the differences of CCl4 liver injury and immunity liver injury mice models].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2005 |
Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.
Topics: 2-Acetylaminofluorene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride | 2006 |
Anti-hepato-cytotoxic serum treatment results in acute liver failure.
Topics: Animals; Blood Component Transfusion; Carbon Tetrachloride; Disease Models, Animal; Liver Failure, A | 2006 |
Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression.
Topics: Alleles; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Dise | 2006 |
Cryopreserved fetal liver cell transplants support the chronic failing liver in rats with CCl4-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Cryopreservation; Cytochrome P-450 Enzyme System; Di | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Disease Progression; Enzyme-Linked Immunosorb | 2006 |
Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Cirrhosis, Experime | 2006 |
Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury.
Topics: Animals; Carbon Tetrachloride; Cytokines; Disease Models, Animal; Etanercept; Immunoglobulin G; Inte | 2006 |
Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Chemical and Drug Induced | 2006 |
[Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat].
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2006 |
Up-regulation of Metabotropic glutamate receptor 3 (mGluR3) in rat fibrosis and cirrhosis model of persistent hypoxic condition.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Hypoxia; Immunohistochemistry; Live | 2007 |
Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity.
Topics: Acetaminophen; Animals; Animals, Newborn; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; C | 2006 |
Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury.
Topics: alpha-Fetoproteins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease | 2006 |
Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Carbon Tetrachloride; Collagen; Disease Models, Animal; Drugs | 2007 |
Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2006 |
Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Differentiation; Disease Models, | 2006 |
Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis.
Topics: Anastomosis, Surgical; Anesthetics, Intravenous; Animals; Carbon Tetrachloride; Disease Models, Anim | 2006 |
Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2007 |
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Biopsy; Carbon Tetrachloride; Cell De | 2007 |
Protective effect of verapamil on multiple hepatotoxic factors-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Dietary Fats; Disease Models, | 2007 |
Rheumatoid factor induction in murine models of liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoimmunity; Carbon Tetrachloride; Chem | 2007 |
The effect of oculo-acupuncture on acute hepatic injury induced by carbon tetrachloride in dogs.
Topics: Acupuncture Points; Acupuncture Therapy; Alanine Transaminase; Animals; Aspartate Aminotransferases; | 2007 |
Involvement of transforming growth factor-beta in the expression of gicerin, a cell adhesion molecule, in the regeneration of hepatocytes.
Topics: Animals; Carbon Tetrachloride; CD146 Antigen; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2007 |
[Cystic degeneration in liver injury induced by CCl4 in SD rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cysts; Disease Models, Animal | 2006 |
Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity.
Topics: Administration, Oral; Aloe; Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dos | 2007 |
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Caspase 3; Cells, Cult | 2007 |
Bacterial translocation is downregulated by anti-TNF-alpha monoclonal antibody administration in rats with cirrhosis and ascites.
Topics: Animals; Antibodies, Monoclonal; Ascitic Fluid; Bacterial Translocation; Carbon Tetrachloride; Disea | 2007 |
FR-167653, a selective p38 MAPK inhibitor, exerts salutary effect on liver cirrhosis through downregulation of Runx2.
Topics: Animals; Carbon Tetrachloride; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Dose-Res | 2007 |
The pharmacodynamics of mivacurium in the rabbit with carbon tetrachloride-induced liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholinesterases; | 2007 |
Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Collagen; Disease Mod | 2007 |
Hepatic stellate cells: the only cells involved in liver fibrogenesis? A dogma challenged.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Re | 2007 |
Increased Smad1 expression and transcriptional activity enhances trans-differentiation of hepatic stellate cells.
Topics: Actins; Adenoviridae; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Cell Prolifera | 2007 |
Development of an experimental model of induced bacterial peritonitis in cirrhotic rats with or without ascites.
Topics: Animals; Anti-Bacterial Agents; Ascites; Bacterial Infections; Carbon Tetrachloride; Ceftriaxone; Di | 2007 |
Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet.
Topics: Alcoholism; Aniline Compounds; Animals; Carbon Tetrachloride; Cell Nucleus; Central Nervous System D | 2006 |
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
Topics: Amidohydrolases; Animals; Blood Pressure; Cannabinoid Receptor Modulators; Carbon Tetrachloride; Dis | 2007 |
Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 2007 |
Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2007 |
Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Collagen; Disease Models, Animal; Disease Progression; Fe | 2007 |
Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Division; Cells, Cultured; Disease Models, An | 2007 |
Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrach | 2007 |
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Topics: Animals; Carbon Tetrachloride; Digestive System; Disease Models, Animal; DNA; Gene Deletion; Hepatec | 2007 |
Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury.
Topics: 2-Acetylaminofluorene; Administration, Oral; alpha-Fetoproteins; Animals; Carbon Tetrachloride; Cell | 2007 |
[The tracking of allogenic grafted rat bone marrow stem cells in rat liver and their role on repairing injured liver].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow Transplantation; Carbon Tetr | 2007 |
Effects of granulocyte colony stimulating-factor in a rat model of acute liver injury.
Topics: Animals; Carbon Tetrachloride; Colony-Stimulating Factors; Disease Models, Animal; Image Cytometry; | 2007 |
Treatment of chronic liver injuries in mice by oral administration of ethanolic extract of the fruit of Hovenia dulcis.
Topics: Administration, Oral; Animals; Aspartate Aminotransferase, Cytoplasmic; Carbon Tetrachloride; Chemic | 2007 |
Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Disease Models, An | 2007 |
Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Disease Models, Animal; Genistein; Immunohistochemis | 2008 |
Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Disease Models, Animal; Enzyme Induction; Heme | 2007 |
Inhibition of the renin-angiotensin system attenuates the development of liver fibrosis and oxidative stress in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxid | 2008 |
Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Liver; Liver Cirrhosis; Mal | 2008 |
Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Hypoxia; Chemokine CCL2; Chemotaxis, Leukocyte; Collagen Type I; | 2008 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 2007 |
Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Body Weight; Carbon Tetrachloride; Disease | 2008 |
Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Ce | 2008 |
Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chin | 2007 |
Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase | 2008 |
Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Endothelin-1; Kupffer Cells; Liver Cirrhosis; | 2008 |
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Spa | 2008 |
Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibrosis; Genes, | 2008 |
Posttranslational activation of endothelial nitric oxide synthase attenuates carbon tetrachloride-induced hepatotoxicity in newborn rats.
Topics: Age Factors; Androstadienes; Animals; Animals, Newborn; Carbon Tetrachloride; Cytoprotection; Diseas | 2008 |
Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatocyt | 2008 |
[Inducing rat liver cirrhosis by adjusting the dosage of CCl4 according to body weight changes].
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Experimental; M | 2008 |
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.
Topics: Animals; Arsenamide; Carbon Tetrachloride; Disease Models, Animal; Female; Genetic Predisposition to | 2008 |
[Study of hepatoprotective activity of ethylmethylhydroxypyridine fumarate and lipoate in the experimental toxic hepatitis].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Femal | 2007 |
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells.
Topics: Animals; Antioxidants; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; Cell | 2008 |
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells.
Topics: Animals; Antioxidants; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; Cell | 2008 |
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells.
Topics: Animals; Antioxidants; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; Cell | 2008 |
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells.
Topics: Animals; Antioxidants; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; Cell | 2008 |
Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Dopamine beta-Hydroxylase; Down-Regulation; G | 2008 |
Laparoscopy-assisted creation of a liver failure model in pigs.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatic Artery; Hepatocytes; Laparoscopy; Liv | 2008 |
Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats.
Topics: Acetylcholine; Acetylcholinesterase; Actins; Animals; Atropine; Bone Morphogenetic Protein 6; Bone M | 2008 |
Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice.
Topics: Alanine Transaminase; Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Collagen; Cyclooxygenas | 2008 |
EVP-ABD-enhanced MRI to evaluate diffuse liver disease in a rat model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Contrast Media; Disease Model | 2008 |
Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease | 1983 |
A sensitive experimental model for the assessment of hepatotoxicity by halogenocompounds: prolactin binding to the specific receptors.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Female; Hydro | 1980 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1983 |
Standardized micronodular cirrhosis in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug | 1984 |
Sensitivity of serum glutamic oxaloacetic transaminase and bile acid levels for the detection of experimental liver injury in rats.
Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug | 1981 |
Changes in expression of the albumin, fibronectin and type I procollagen genes in CCl4-induced liver fibrosis: effect of pyridoxol L,2-pyrrolidon-5 carboxylate.
Topics: Albumins; Animals; Blotting, Northern; Carbon Tetrachloride; Disease Models, Animal; Drug Combinatio | 1993 |
Assessment of the carbon tetrachloride-induced cirrhosis model for studies of nitrogen metabolism in chronic liver disease.
Topics: Amino Acids; Animals; Carbon Tetrachloride; Cholesterol; Disease Models, Animal; Fatty Acids, Nonest | 1994 |
Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin.
Topics: Amino Acid Sequence; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1993 |
Effect of ursodeoxycholic acid on in vivo and in vitro toxic liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Car | 1994 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1994 |
CCL4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Copper; Disease Models, Animal; Estradiol; | 1994 |
Hepatoprotective effects of Taiwan folk medicine: wedelia chinensis on three hepatotoxin-induced hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotr | 1994 |
Effects of zinc on hepatic ornithine transcarbamylase (OTC) activity.
Topics: Ammonia; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental | 1993 |
Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carboxylic Es | 1993 |
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
Topics: Allantoin; Aluminum Hydroxide; Animals; Antacids; Aspirin; Carbon Tetrachloride; Diethylnitrosamine; | 1994 |
[Establishment of a model of human gastric cancer with liver metastasis in nude mice].
Topics: Adenocarcinoma, Mucinous; Animals; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Neopl | 1993 |
Liver distribution of 99mTc-DL-homocysteine in experimental hepatitis rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Interactions; Hepatitis, Viral, Animal; | 1993 |
Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 1993 |
Pharmacological and pathological studies on Taiwan folk medicine (IX): The hepatoprotective effect of the methanolic extract from echinops grijisii.
Topics: 1-Butanol; Acetates; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biopsy; Butanols; C | 1993 |
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; | 1993 |
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Membrane; Disease Models, Animal; Fatty Liver, Alcoholic; Fibros | 1993 |
Hepatocarcinogenic potency of mixed and pure enantiomers of trans-7,8-dihydrobenzo[a]pyrene-7,8-diol in trout.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Tetrachloride; Dihydroxydihydrobenzopyrenes; Dis | 1993 |
Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis.
Topics: Actin Cytoskeleton; Actins; Animals; Carbon Tetrachloride; Cytoskeleton; Desmin; Disease Models, Ani | 1993 |
Acute-phase response in rat to carbon tetrachloride-azathioprine induced cirrhosis and partial hepatectomy of cirrhotic liver.
Topics: Acute-Phase Reaction; alpha 1-Antitrypsin; Animals; Antimetabolites; Azathioprine; Carbon Tetrachlor | 1996 |
A potential experimental model for the study of osteopenia in CCl4 liver cirrhotic rats.
Topics: Animals; Body Weight; Bone Diseases, Metabolic; Carbon Tetrachloride; Densitometry; Disease Models, | 1996 |
Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Dise | 1997 |
Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; C | 1996 |
The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver.
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Disease Models, Animal; Female; Histamine; Hypertension | 1997 |
Protective effect of Rhinax, a herbal formulation, against CCl4-induced liver injury and survival in rats.
Topics: Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cytochrome P-450 E | 1997 |
Cytoprotective activity in the gastric mucosa of rats exposed to carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Disease Models, Animal; Drug Resistance; Ethanol; Gastr | 1997 |
A microcholangiographic study of liver disease models in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Duct Diseases; Bile Ducts; Carbon Tetrachloride; Cell Divisi | 1995 |
Effect of narcotic agents and of bleeding on systemic and renal haemodynamics in healthy and CCl4-treated cirrhotic rats.
Topics: Animals; Blood Pressure; Butyrophenones; Carbon Tetrachloride; Diazepam; Disease Models, Animal; Dru | 1997 |
Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cyanobacteria; Disease Models, Animal; Fatty Liver; Li | 1998 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal | 1998 |
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver.
Topics: Animals; Apoptosis; Bicarbonates; Bile; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Cell Divisio | 1999 |
[Effects of calcitriol and alfacalcidol on an osteoporosis model in rats with hepatic failure].
Topics: Animals; Bone Density; Calcitriol; Calcium; Carbon Tetrachloride; Disease Models, Animal; Female; Hu | 1999 |
Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 1999 |
Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone.
Topics: Ammonia; Animals; Anti-Ulcer Agents; Carbon Tetrachloride; Disease Models, Animal; Diterpenes; Gastr | 1999 |
Functional capacity of the cirrhotic liver after partial hepatectomy in the rat.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatectomy; Liver Cirrhosis, Experimental; L | 1999 |
31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbon Tetrachloride; Carbon Tetrachloride P | 1999 |
Spleno-renal shunt blood flow is an accurate index of collateral circulation in different models of portal hypertension and after pharmacological changes in rats.
Topics: Animals; Carbon Tetrachloride; Collateral Circulation; Dimethylnitrosamine; Disease Models, Animal; | 2000 |
Protective effects of seaweeds against liver injury caused by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2000 |
Progression of hepatic stellate cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesis.
Topics: Actins; Animals; Arginase; Biological Assay; Carbon Tetrachloride; Cells, Cultured; Cytokines; Disea | 2000 |
The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Artemisia; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Hot Temperature; Hydroxyp | 2000 |
FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; | 2000 |
Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Male; | 2000 |
Yang-Gan-Wan protects mice against experimental liver damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2000 |
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Li | 2000 |
Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Anim | 2000 |
Three-dimensional observations of spatial arrangement of hepatic zonation and vein system in mice and house musk shrews.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Di | 2000 |
Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Colchicine; Disease Models, Animal; Dose-Response Relat | 2000 |
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
Topics: Albumins; Animals; Anthraquinones; Antineoplastic Agents; Aspartate Aminotransferases; Blotting, Nor | 2000 |
Ampelopsis brevipedunculata (Vitaceae) extract inhibits a progression of carbon tetrachloride-induced hepatic injury in the mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2000 |
Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide.
Topics: Animals; Carbon Tetrachloride; Cell Cycle Proteins; Disease Models, Animal; Liver Cirrhosis; Male; R | 2001 |
Pneumolysin-induced complement depletion during experimental pneumococcal bacteremia.
Topics: Animals; Bacteremia; Bacterial Proteins; Carbon Tetrachloride; Complement Activation; Complement C3; | 2001 |
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Fractionation; Cell Line; Cells, Cultured; Chemokine | 2001 |
A rat model of liver cirrhosis and esophageal varices.
Topics: Animals; Carbon Tetrachloride; Collateral Circulation; Disease Models, Animal; Esophageal and Gastri | 2001 |
Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; C | 2001 |
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.
Topics: Animals; Anti-Allergic Agents; Apoptosis; Calcium; Carbon Tetrachloride; Chlorpromazine; Collagen; C | 2001 |
Induction of hepatic tissue-type plasminogen activator and type 1 plasminogen activator-inhibitor gene expressions and appearance of their translation products in the bile following acute liver injury in rats.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2001 |
Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection.
Topics: Adrenergic beta-Antagonists; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Di | 2001 |
[The coordinated expression of laminin and its integrin receptor in hepatic sinusoidal capillarization].
Topics: Animals; Antigens, CD; Carbon Tetrachloride; Disease Models, Animal; Integrin alpha6; Laminin; Liver | 2001 |
Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Division; Col | 2001 |
[The role of nitric oxide in hyperdynamic circulation in portal hypertensive rats].
Topics: Animals; Arginine; Carbon Tetrachloride; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Hy | 1998 |
[Dynamic expression of tenascin in rat liver during liver fibrogenesis induced by CCl(4)].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Extracellular Matrix Proteins; Image Processi | 2002 |
[Effects of glycyrrhetinic acid and IFN-alpha on HSCs collagen metabolism in rat fibrotic liver of varying stages].
Topics: Alcohols; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Disease Models, Animal; | 2002 |
[Experimental study of the therapeutic effect of interferon-alpha on liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Collagen Type IV; Disease Models, Animal; Hyaluronic Acid; Inflammati | 2002 |
Role of plant metabolites in toxic liver injury.
Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; | 2002 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; C | 2002 |
Tropoelastin expression is up-regulated during activation of hepatic stellate cells and in the livers of CCl(4)-cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Electrophoresis, Aga | 2002 |
Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b--an antiendotoxin.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, Animal; Female; Genta | 1978 |
[Experiments to reproduce Yersinia enterocolitica type 9 infection in guinea pigs].
Topics: Administration, Oral; Administration, Topical; Animals; Carbon Tetrachloride; Disease Models, Animal | 1976 |
Manganese induced hepatic lesions in carbon tetrachloride pretreated rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 1975 |
Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Proteins; Ca | 1992 |
Gastric mucosal blood flow distribution in the CCl4-induced cirrhotic rat--a model of portal hypertensive gastropathy?
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Disease Models, Animal; Gastric Mucosa; Hyperten | 1992 |
Pharmacological and pathological studies on hepatic protective crude drugs from Taiwan (V): The effects of Bombax malabarica and Scutellaria rivularis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1992 |
Liver cirrhosis induced by carbon tetrachloride and the effect of superoxide dismutase and xanthine oxidase inhibitor treatment.
Topics: Allopurinol; Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Ex | 1992 |
Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture.
Topics: Actins; Adipose Tissue; Animals; Carbon Tetrachloride; Cell Division; Cell Separation; Common Bile D | 1992 |
Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzazepines; Carbon Tetrachloride; Chem | 1991 |
Mucosal lesions of the stomach in liver cirrhosis with a special reference to phospholipid metabolism.
Topics: Animals; Bile Reflux; Carbon Tetrachloride; Disease Models, Animal; Gastric Mucosa; Liver Cirrhosis, | 1991 |
The hepatic microcirculation in experimental cirrhosis. A scanning electron microscopy study of microcorrosion casts.
Topics: Animals; Carbon Tetrachloride; Corrosion Casting; Disease Models, Animal; Liver; Liver Cirrhosis, Ex | 1991 |
Pneumococcal pneumonia in a rat model of cirrhosis: effects of cirrhosis on pulmonary defense mechanisms against Streptococcus pneumoniae.
Topics: Animals; Antigens, Bacterial; Carbon Tetrachloride; Complement System Proteins; Disease Models, Anim | 1991 |
A rodent model of cirrhosis, ascites, and bacterial peritonitis.
Topics: Animals; Ascites; Bacterial Infections; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosi | 1991 |
Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "low-dose" carbon tetrachloride vapor in the rat.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, | 1991 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; O | 1991 |
Impaired hepatic handling and processing of lysophosphatidylcholine in rats with liver cirrhosis.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Carbon Radioisotopes; Carbon Tetrachloride; | 1991 |
Two rat models of hepatic fibrosis. A morphologic and molecular comparison.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Collagen; Disease Models, Animal; Gene Expr | 1990 |
Availability of exchange blood transfusion and plasma exchange in treatment of acute liver failure.
Topics: Acute Disease; Animals; Blood Transfusion; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1990 |
Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury.
Topics: Acute Disease; Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 1989 |
Problems with animal models of chronic liver disease: suggestions for improvement in standardization.
Topics: Animals; Behavior, Animal; Carbon Tetrachloride; Chronic Disease; Disease Models, Animal; Hepatic En | 1989 |
Longitudinal study of renal prostaglandin excretion in cirrhotic rats: relationship with the renin-aldosterone system.
Topics: 6-Ketoprostaglandin F1 alpha; Aldosterone; Animals; Carbon Tetrachloride; Disease Models, Animal; Ki | 1988 |
Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Synergism; Ethanol; Liver; Liver Cirrhos | 1988 |
The effect of prostaglandins, branched-chain amino acids and other drugs on the outcome of experimental acute porcine hepatic failure.
Topics: Acetylcysteine; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Carbon Tetrachloride; | 1987 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
[Substance-induced liver injury as a model for evaluating hepatoprotective drugs].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 1985 |
[Changes in the bile secretion and bile ductules in the course of development of experimental hepatitis and liver cirrhosis].
Topics: Acute Disease; Adenosine Triphosphatases; Animals; Bile; Bile Ducts; Carbon Tetrachloride; Chemical | 1971 |
[Experimental carbon tetrachloride poisoning and fat embolism in rabbits].
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Disease Models, | 1974 |
Experimental siderosis and liver injury in the rhesus monkey.
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Haplorhini; | 1972 |
The effects of azathioprine on CCl4 induced cirrhosis in the rat.
Topics: Adenosine Triphosphate; Animals; Azathioprine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1974 |
[Behavior of serum protein fractions--especially of glycoproteins--in an inflammation model under varied response conditions].
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Ceruloplasmin; Disease Models, Animal; Electrophoresi | 1971 |
[Comparative studies on the induction of chronic hepatitis in the rat].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Diabetes Mel | 1971 |
Effect of sirepar on experimental cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fatty Liver; Liver; Liver Cirrhosis; Liver Ex | 1970 |
Studies on the effect of various anthelmintics upon Fasciola hepatica in albino rats.
Topics: Age Factors; Animals; Anthelmintics; Carbon Tetrachloride; Disease Models, Animal; Fasciola hepatica | 1970 |