carbon tetrachloride has been researched along with Cirrhoses, Experimental Liver in 921 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the role of tolvaptan in regulating aquaporin (AQP)-2 expression and fecal water content in cirrhotic rats with ascites." | 7.83 | Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. ( Chen, C; Chen, RP; Huang, XL; Huang, ZM; Lin, HH; Zhang, WY, 2016) |
| " This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension." | 7.75 | Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats. ( Alatsakis, M; Ballas, KD; Marakis, GN; Pavlidis, TE; Psarras, K; Rafailidis, S; Sakantamis, AK; Tzioufa-Asimakopoulou, V, 2009) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 7.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| "The role of heat shock pretreatment in the induction of tolerance for ischemia-reperfusion injury was investigated in rat livers with fibrosis produced by carbon tetrachloride (CCI4) injected subcutaneously." | 7.70 | Induction of heat shock response: effect on the rat liver with carbon tetrachloride-induced fibrosis from ischemia-reperfusion injury. ( Kimoto, S; Kume, M; Morimoto, T; Okamoto, R; Shimabukuro, T; Yamamoto, Y; Yamaoka, Y, 1998) |
| "Hepatic granulomas induced by a single or several subcutaneous injections of carbon tetrachloride (CCl4) in Balb/c mice were examined electronmicroscopically and immunocytochemically." | 7.68 | Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride. ( Lukita-Atmadja, W; Sato, T; Wake, K, 1993) |
| " To assess the metabolic response to starvation in an animal model of cirrhosis, glycogen and fuel metabolism were characterized in rats with CCl4-induced cirrhosis studied 2 wk after 10 weekly doses of CCl4." | 7.68 | Decreased hepatic glycogen content and accelerated response to starvation in rats with carbon tetrachloride-induced cirrhosis. ( Brass, EP; Krahenbuhl, S; Weber, FL, 1991) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 7.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 7.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 6.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "Curcumin is a phytophenolic compound, which is highly efficacious for treating several inflammatory diseases." | 5.35 | Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. ( Moreno, MG; Muriel, P; Reyes-Gordillo, K; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| " To establish new clinical therapies for patients with liver cirrhosis using autologous BMC, we developed a new in vivo murine model using green fluorescent protein (GFP) and repeated carbon tetrachloride (CCl(4)) injection." | 4.84 | Autologous bone marrow cell infusion therapy for liver cirrhosis. ( Sakaida, I, 2008) |
| "Norfloxacin administration is useful in preventing bacterial infections in cirrhosis but associated to the generation of resistant species." | 3.88 | Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis. ( Bellot, P; Francés, R; García, I; Gimenez, P; Gómez-Hurtado, I; González-Navajas, JM; Guarner, F; Manichanh, C; Ramos, JM; Such, J; Zapater, P, 2018) |
| "To investigate the role of tolvaptan in regulating aquaporin (AQP)-2 expression and fecal water content in cirrhotic rats with ascites." | 3.83 | Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. ( Chen, C; Chen, RP; Huang, XL; Huang, ZM; Lin, HH; Zhang, WY, 2016) |
| "Cirrhotic patients often demonstrate glucose intolerance, one of the possible causes being a decreased glycogen-synthesizing capacity of the liver." | 3.80 | Activity of glycogen synthase and glycogen phosphorylase in normal and cirrhotic rat liver during glycogen synthesis from glucose or fructose. ( Bezborodkina, NN; Chestnova, AY; Kudryavtsev, BN; Okovity, SV, 2014) |
| "Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis." | 3.80 | Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis. ( Chang, HC; Chen, RJ; Chiu, YW; Huang, CY; Kuo, YC; Lin, JA; Lin, YM; Liu, JY; Tsai, CH; Tsai, FJ, 2014) |
| " After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
| " DPP8 and DPP9 expression were measured in epidermal growth factor (EGF) treated Huh7 hepatoma cells, in fibrotic liver samples from mice treated with carbon tetrachloride (CCl₄) and from multidrug resistance gene 2 (Mdr2/Abcb4) gene knockout (gko) mice with biliary fibrosis, and in human end stage primary biliary cirrhosis (PBC)." | 3.79 | Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. ( Ajami, K; Bertolino, P; Chen, Y; Chowdhury, S; Gorrell, MD; McCaughan, GW; Popov, Y; Schuppan, D; Wang, XM; Yao, TW; Yu, DM, 2013) |
| " Carbon tetrachloride and methionine/choline deficiency were used as chronic liver injury models." | 3.77 | Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. ( Beaven, SW; Bensinger, S; Hong, C; Tontonoz, P; Tsukamoto, H; Wang, J; Wroblewski, K, 2011) |
| " In the present study, we address the role of Gas6 in steatohepatitis and progression to liver fibrosis using Gas6-deficient mice fed a choline-deficient ethionine-supplemented diet (CDE) or receiving a chronic carbon tetrachloride (CCl(4)) treatment." | 3.77 | Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice. ( Brouillet, A; Chobert, MN; Couchie, D; Fourcot, A; Laperche, Y; Mavier, P; Zafrani, ES, 2011) |
| " We used antibiotic (norfloxacin) and different probiotic treatments to change the status of gut flora in the cirrhotic rats and evaluated BT, liver function, and endotoxemia in the different models." | 3.76 | Intestinal flora imbalance results in altered bacterial translocation and liver function in rats with experimental cirrhosis. ( Chen, L; Chen, S; Chen, Y; Deng, H; Gao, Z; Gu, Y; Zhang, G; Zhang, W, 2010) |
| " This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension." | 3.75 | Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats. ( Alatsakis, M; Ballas, KD; Marakis, GN; Pavlidis, TE; Psarras, K; Rafailidis, S; Sakantamis, AK; Tzioufa-Asimakopoulou, V, 2009) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 3.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| " CCl4 administration resulted in hepatic necrosis and significant increases in plasma transaminase activities as well as hepatic malondialdehyde (MDA) and diene conjugate (DC) levels in the liver of rats." | 3.74 | Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. ( Cevikbaş, U; Koçak-Toker, N; Mehmetçik, G; Ozdemirler, G; Uysal, M, 2008) |
| "Carbon tetrachloride (CCl4)-induced hepatic fibrosis has been considered to be linked to oxidative stress and mediated by aldehydic lipid peroxidation products." | 3.73 | F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis? ( Arezzini, B; Comporti, M; Gardi, C; Monaco, B; Sgherri, C; Signorini, C, 2005) |
| "The role of heat shock pretreatment in the induction of tolerance for ischemia-reperfusion injury was investigated in rat livers with fibrosis produced by carbon tetrachloride (CCI4) injected subcutaneously." | 3.70 | Induction of heat shock response: effect on the rat liver with carbon tetrachloride-induced fibrosis from ischemia-reperfusion injury. ( Kimoto, S; Kume, M; Morimoto, T; Okamoto, R; Shimabukuro, T; Yamamoto, Y; Yamaoka, Y, 1998) |
| "5 mg/kg from the beginning of the induction of dimethylnitrosamine liver cirrhosis to day 28, dHGF dose-dependently ameliorated thrombocytopenia and completely prevented it at a dose of 0." | 3.69 | Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis. ( Fujise, N; Higashio, K; Masunaga, H; Shiota, A; Yamashita, Y; Yasuda, H, 1997) |
| " We investigated to what extent antipyrine clearance and metabolite formation are impaired in two models of liver cirrhosis in the rat, namely micronodular cirrhosis induced by chronic exposure to phenobarbital/CCl4 and biliary cirrhosis induced by bile duct ligation." | 3.68 | Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition. ( Buters, JT; Reichen, J; Zysset, T, 1993) |
| "Hepatic granulomas induced by a single or several subcutaneous injections of carbon tetrachloride (CCl4) in Balb/c mice were examined electronmicroscopically and immunocytochemically." | 3.68 | Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride. ( Lukita-Atmadja, W; Sato, T; Wake, K, 1993) |
| " Artificial-chylomicron delipidation and remnant disappearance from plasma were investigated in rats with carbon tetrachloride-induced hepatic cirrhosis or with cholestasis due to bile-duct ligation." | 3.68 | Chylomicron metabolism in experimental cirrhosis and cholestasis. ( Albuquerque, MR; Damião, AO; Laudanna, AA; Quintão, EC; Sipahi, AM, 1993) |
| " To assess the metabolic response to starvation in an animal model of cirrhosis, glycogen and fuel metabolism were characterized in rats with CCl4-induced cirrhosis studied 2 wk after 10 weekly doses of CCl4." | 3.68 | Decreased hepatic glycogen content and accelerated response to starvation in rats with carbon tetrachloride-induced cirrhosis. ( Brass, EP; Krahenbuhl, S; Weber, FL, 1991) |
| "We sought to develop a rodent model of spontaneous bacterial peritonitis and report here the preliminary results of carbon tetrachloride-induced cirrhosis in which ascites and bacterial peritonitis predictably develop." | 3.68 | A rodent model of cirrhosis, ascites, and bacterial peritonitis. ( Kanel, G; Mellencamp, MA; Runyon, BA; Sugano, S, 1991) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 3.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| "To determine whether interstitial pulmonary edema occurs or not in experimental cirrhotic rats, male Sprague-Dawley rats were given carbon tetrachloride subcutaneously in order to induce liver cirrhosis." | 3.67 | Pulmonary interstitial edema in experimental cirrhosis of the liver in rats. ( Furukawa, T; Inokuchi, K; Yasumoto, K, 1984) |
| " To investigate the effect of liver injury on the removal and the production of acetaldehyde, we produced fibrosis and cirrhosis (by chronic administration of carbon tetrachloride) and fatty liver (with very small doses of dimethylnitrosamine) in rats." | 3.67 | High levels of acetaldehyde in nonalcoholic liver injury after threonine or ethanol administration. ( Baraona, E; Hernández-Muñoz, R; Lieber, CS; Ma, XL, 1989) |
| "The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA)." | 3.67 | Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis. ( Lekholm, U; Stenman, G, 1989) |
| "The present study investigated whether, in rats with portal hypertension due to cirrhosis of the liver induced by carbon tetrachloride, blood volume restitution following a hemorrhage produces an increase of portal pressure beyond control values, as observed in rats with prehepatic portal hypertension." | 3.67 | Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting. ( Arderiu, M; Bosch, J; Kravetz, D; Pilar Pizcueta, M; Rodés, J, 1989) |
| " Experimental liver cirrhosis was induced by subcutaneous injections of 50% carbon tetrachloride in a dose of 2 mL/kg body weight twice a week for 16 weeks." | 3.67 | Pancreatic endocrine function in cirrhotic rats. ( Baba, S; Fujii, M; Fujisawa, T; Nakamura, T; Oka, T; Okabayashi, Y; Otsuki, M; Tani, S, 1988) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 3.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| " We induced cirrhosis with hypertrophy in rats by simultaneous treatment with CCl4 and phenobarbital (PB) and devised a hierarchy of structure applicable to the sampling and morphometric analysis of untreated and PB-treated control livers and of cirrhotic livers." | 3.66 | A morphometric analysis of the hypertrophy of experimental liver cirrhosis. ( Buschmann, RJ; Ryoo, JW, 1983) |
| "In the context of basic research in liver fibrosis and cirrhosis, it is essential to keep in mind that the capacity of the organ to recover spontaneously might be a significant limitation to long-term studies that use experimental models of liver cirrhosis." | 2.82 | Liver cirrhosis: An overview of experimental models in rodents. ( Dias, ML; Dos Santos Goldenberg, RC; Faccioli, LAP; Paranhos, BA, 2022) |
| "Liver cirrhosis was produced by weekly feeding of CCl(4) for 8 weeks." | 2.77 | Gender different response to immunonutrition in liver cirrhosis with sepsis in rats. ( Chen, CY; Hwang, TL, 2012) |
| "Hepatorenal syndrome is still one of the most important challenges of medicine in the 21st century." | 2.41 | [Hepatorenal syndrome in view of experimental studies]. ( Saracyn, M, 2002) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 2.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "TGF-β signaling links HSC activation to liver fibrosis and tumorigenesis." | 1.62 | Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries. ( Ge, G; Lin, M; Peng, YJ; Ren, Z; Shang, G; Tang, XT; Wang, SS; Yin, X; Yuan, J; Zhou, BO, 2021) |
| "Mice with liver fibrosis after BDL had increased hepatic PFKFB3; injection of 3PO immediately after the surgery prevented HSC activation and reduced the severity of liver fibrosis compared with mice given vehicle." | 1.56 | CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis. ( Bartrons, R; Fernandez, M; Gallego, J; Manzano, A; Mejias, M; Mendez, R; Naranjo-Suarez, S; Pell, N; Ramirez, M; Suñer, C, 2020) |
| "Rosiglitazone (RGZ) is a highly potent agonist of PPARγ." | 1.51 | Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis. ( Chen, SZ; Li, JJ; Li, YY; Yu, FX; Zheng, YH; Zhi, SC, 2019) |
| "An animal model of chronic liver failure was developed, and undifferentiated human cord blood mesenchymal stem cells, in vitro hepato-genically differentiated mesenchymal stem cells, or freshly isolated rat hepatocytes were transplanted into a CCL4 cirrhotic experimental model." | 1.48 | Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study. ( Atta, S; Demerdash, Z; El Baz, H; Hammam, O; Hassan, S; Kamel, M; Khalil, H; Meshaal, S; Raafat, I; Salah, F, 2018) |
| "Thymosin β4 (Tβ4) has been shown to have beneficial effects in a number of pathological processes." | 1.46 | Thymosin β4 attenuates liver fibrosis via suppressing Notch signaling. ( Hong, Y; Yao, Q; Zheng, L, 2017) |
| " Therefore, the effects of the orally bioavailable synthetic triterpenoid 2-cyano-3,12-dioxooleana- 1,9(11)-dien-28-oate-ethyl amide (CDDO-EA, RTA 405), which has potent antioxidative and antiinflammatory properties, was evaluated in a chronic carbon tetrachloride (CCl(4))-induced model of liver cirrhosis and hepatocellular carcinoma (HCC)." | 1.43 | The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury. ( Cusimano, FA; Getachew, Y; Gopal, P; Reisman, SA; Shay, JW, 2016) |
| "Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, and inducible nitric oxide synthase mRNA levels." | 1.43 | Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. ( Bak, J; Cheong, KO; Chung, HY; Je, NK; Kim, KW; Lee, C; Moon, JO; Shin, DS; Yoon, S, 2016) |
| " We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepatic fibrosis progression/reversalin vivousing chronic administration of irreversible LOX inhibitor β-aminopropionitrile (BAPN, or vehicle as control) in C57Bl/6J mice with carbon tetrachloride (CCl4)-induced fibrosis." | 1.43 | Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice. ( Greenstein, A; Ikenaga, N; Liu, SB; Peng, ZW; Popov, Y; Schuppan, D; Smith, V; Sverdlov, DY, 2016) |
| "Hepatocarcinogenesis was significantly accelerated in the fibrotic livers compared to those of the control, significantly decreasing the life span of the mice." | 1.43 | Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. ( Ahn, SH; Cho, KJ; Chung, SI; Han, KH; Ju, HL; Kim, DY; Moon, H; Ro, SW, 2016) |
| "Chlordecone is a chlorinated pesticide used in the 1990s." | 1.43 | Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice. ( Gelu-Simeon, M; Genet, V; Lucas-Clerc, C; Piquet-Pellorce, C; Samson, M; Tabet, E; Tiaho, F, 2016) |
| "Upon carbon tetrachloride treatment, a higher lipid content and the presence of catabolic products indicated cirrhosis in tissue samples." | 1.43 | Hepatic cirrhosis and recovery as reflected by Raman spectroscopy: information revealed by statistical analysis might lead to a prognostic biomarker. ( Bauer, M; Fröhlich, E; Galler, K; Kortgen, A; Neugebauer, U; Popp, J, 2016) |
| "Givinostat treatment increased intracellular reactive oxygen species production, decreased mitochondrial membrane potential, and promoted mitochondrial permeability transition pore opening." | 1.42 | Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. ( Meng, WY; Shi, M; Wang, N; Wang, T; Wang, YG; Wei, J; Xu, L, 2015) |
| "Serum levels of Slit2 in patients with liver fibrosis were determined by ELISA." | 1.42 | Activation of Slit2-Robo1 signaling promotes liver fibrosis. ( Cao, L; Chang, J; Ding, Y; Gou, H; Gu, Q; Ji, X; Lan, T; Li, C; Li, J; Ou, Y; Qi, C; Qiao, L; Wang, L; Wen, D; Wu, T; Zhang, Q; Zheng, L, 2015) |
| " The dose-response curve to norepinephrine in mesenteric arteriole was shifted to the right, and EC50 was significantly increased in cirrhotic patients and rats." | 1.39 | Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats. ( Chen, W; Huo, YM; Liu, DJ; Qin, J; Sang, JY; Wu, ZY; Xu, J, 2013) |
| " The underlying mechanisms may relate to rescue NO bioavailability from macrophage-derived peroxynitrite in portal triads." | 1.39 | Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis. ( Cai, DY; Deng, B; Liu, XT; Song, YJ; Wang, YQ; Xu, XY; Yang, SJ; Zhang, T; Zhao, X, 2013) |
| "Hepatorenal syndrome is one of the serious complications of cirrhosis and closely associated with the increasing intra-abdominal pressure (IAP)." | 1.39 | Hepatorenal syndrome: insights into the mechanisms of intra-abdominal hypertension. ( Chang, Y; Ding, T; Li, Z; Qi, X; Wang, F; Wang, S; Xiao, C; Yang, C; Zhang, Z, 2013) |
| " Moreover, we evaluated endothelial function by dose-relaxation curves to acetylcholine, hepatic NO bioavailability and TXA2 production." | 1.39 | Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; Di Pascoli, M; Diví, M; García-Pagán, JC; Gracia-Sancho, J; Rodríguez-Vilarrupla, A; Rosado, E; Vilaseca, M, 2013) |
| "Largazole is a novel histone deacetylase (HDAC) inhibitor." | 1.39 | A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling. ( Friedman, SL; Ji, L; Kwong, S; Lam, W; Li, F; Liu, Y; Lui, EL; Ren, Q; Tang, S; Wang, J; Wang, X; Wang, Z; Xu, Z; Ye, T; Zhang, H; Zhou, S, 2013) |
| "Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process." | 1.38 | Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. ( Fiel, MI; Ge, X; Lu, Y; Mormone, E; Nieto, N, 2012) |
| "Elastin has been linked to maturity of liver fibrosis." | 1.38 | Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. ( Aucott, RL; Benyon, RC; Duffield, JS; Fallowfield, JA; Forbes, SJ; Hartland, SN; Iredale, JP; Pellicoro, A; Ramachandran, P; Robson, AJ; Snowdon, VK; Vernon, M, 2012) |
| "Xanthohumol was applied orally at a dose of 1 mg/g body weight 2 days prior as well as during and after exposure to CCl(4)." | 1.38 | Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis. ( Dorn, C; Heilmann, J; Hellerbrand, C, 2012) |
| "Tectorigenin was also able to inhibit the increase in the liver lipid peroxidation (LPO), as well as the decrease in the activities of liver superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), caused by liver fibrosis." | 1.38 | The therapeutic effects of tectorigenin on chemically induced liver fibrosis in rats and an associated metabonomic investigation. ( Chen, YX; Cui, JT; Gao, XX; Jiang, CP; Shi, DH; Wang, YR; Wu, JH, 2012) |
| "Hydroxyproline content was decreased in both NIM811 groups compared with the model (P < 0." | 1.37 | N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. ( Jia, J; Wang, H; Wang, T; You, H; Zhang, Y, 2011) |
| "5-fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of the rats at a dose of 1." | 1.37 | Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats. ( Arimori, K; Hatakeyama, K; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2011) |
| "Losartan treatment increased sinusoidal diameter, sinusoidal blood flow and portal vein flow after partial hepatectomy (P<0." | 1.37 | Role of angiotensin-1 receptor blockade in cirrhotic liver resection. ( Bahde, R; Hölzen, JP; Kebschull, L; Minin, E; Palmes, D; Schmidt, HH; Siaj, R; Spiegel, HU; Stöppeler, S; Zibert, A, 2011) |
| "Cirrhotic portal hypertension is characterized by mesenteric arterial vasodilation and hyporeactivity to vasoconstrictors." | 1.37 | Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats. ( Angeli, P; Bolognesi, M; Calabrese, F; Di Pascoli, M; Gatta, A; Lunardi, F; Merkel, C; Pontisso, P; Sacerdoti, D; Turato, C; Verardo, A; Zampieri, F, 2011) |
| " Using a bivascular liver perfusion dose-response curves to adenosine of the HA were performed in the presence and the absence of pan-adenosine blocker (8-SPT), A1 blocker (caffeine) or nitric oxide synthase-blocker (l-NMMA) after preconstriction with an alpha1-agonist (methoxamine)." | 1.36 | A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver. ( Groszmann, RJ; Mehal, WZ; Ripoll, C; Zipprich, A, 2010) |
| "Liver fibrosis was induced in Sprague-Dawley rats (n = 12) by repetitive dosing of carbon tetrachloride (CCl(4))." | 1.36 | Diffusion tensor imaging of liver fibrosis in an experimental model. ( Cheung, JS; Chow, AM; Fan, SJ; Gao, DS; Man, K; Wu, EX, 2010) |
| "Pirfenidone is a synthetic molecule which oxidative action has not been tested in cirrhosis." | 1.35 | Potent antioxidant role of pirfenidone in experimental cirrhosis. ( Armendáriz-Borunda, J; Castrejón-Gómez, E; López-Reyes, A; Ruiz-Corro, L; Salazar-Montes, A, 2008) |
| "Curcumin is a phytophenolic compound, which is highly efficacious for treating several inflammatory diseases." | 1.35 | Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. ( Moreno, MG; Muriel, P; Reyes-Gordillo, K; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| "These models represent, respectively, a secondary biliary cirrhosis and alcoholic cirrhosis." | 1.35 | Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation. ( Colle, I; De Vos, M; Geerts, AM; Praet, M; Van Vlierberghe, H; Vanheule, E, 2008) |
| "Glycogen was almost depleted by CCl4 but was partially preserved by trolox." | 1.35 | Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis. ( Fernández-Martínez, E; Galicia-Moreno, M; Moreno, MG; Muriel, P; Pérez-Alvarez, VM; Reyes-Gordillo, K; Rodríguez-Rivera, A; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| " NO scavenging by superoxide (O(2)(-)) further contributes to a reduction of NO bioavailability in cirrhotic livers." | 1.35 | Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension. ( Bosch, J; Chu, Y; García-Pagán, JC; Gracia-Sancho, J; Heistad, DD; Laviña, B; Rodríguez-Vilarrupla, A, 2009) |
| "Substance P (SP) is a vasodilator that may contribute to systemic and splanchnic vasodilatation in cirrhosis." | 1.35 | Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis. ( Afdhal, NH; Bodkin, S; Cardenas, A; Kenney, T; Lamorte, WW; Lowe, R; Oh, S, 2008) |
| "Melatonin treatment significantly reduced MDA levels and elevated SOD and GSH-Px activities in rats received CCl(4) plus melatonin." | 1.35 | Inhibition of carbon tetrachloride-mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis. ( Kus, I; Ogeturk, M; Pekmez, H; Sahin, S; Sarsilmaz, M; Yekeler, H, 2008) |
| "Glycogen was decreased markedly by CCl(4) and resveratrol prevented almost completely this effect." | 1.35 | Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats. ( Chávez, E; Moreno, MG; Muriel, P; Reyes-Gordillo, K; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| "Carbon tetrachloride (CCl4) is a xenobiotic used extensively to induce oxidative stress and is one of the most widely used hepatic toxins for experimental induction of liver fibrosis in the laboratory." | 1.35 | Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. ( Ho, PC; Hsieh, YS; Huang, CY; Liu, JY; Liu, YC; Shyu, JC; Tsai, CC; Tsai, JH; Wu, TT, 2008) |
| "Hepatic fibrosis models were induced by subcutaneous injection of CCl(4) at a dosage of 3 mL/kg in rats." | 1.34 | Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. ( Cheng, YA; Dang, SS; Li, ZF; Liu, ZG; Song, P; Wang, BF, 2007) |
| " A threefold stimulation of collagen fractional synthesis was observed under the maximum dosage of carbon tetrachloride (CCl(4); 1." | 1.34 | Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions. ( Awada, M; Bautista, A; Gardner, JL; Hellerstein, MK; Lindwall, G; Turner, SM, 2007) |
| "Hydroxyproline was 504." | 1.34 | Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats. ( Cao, BQ; Chen, R; Huang, SB; Lin, JZ; Lin, N; Tang, ZF; Xiang, P; Xu, RY; Zhong, YS, 2007) |
| "6 and 30% decrease in ALT and AST, while DDB (75 mg/kg) combined with silymarin (22 mg/kg) resulted in 58." | 1.34 | Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats. ( Abdel-Salam, OM; Morsy, FA; Sleem, AA, 2007) |
| "Curcumin treatment could reduce the expression of PDGF-BB, P < 0." | 1.34 | [The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine]. ( Fang, L; He, YJ; Lu, X; Shu, JC; Wang, HL; Ye, GR, 2007) |
| " PGE2 administration started 3 h after the additional dosing of CCl4 and PGE2 effect on hepatorenal function was examined on days 1, 2, 3, and 7." | 1.33 | PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. ( Armendáriz-Borunda, J; Covarrubias, A; Cruz, C; Estanes, A; Islas-Carbajal, MC; Panduro, A; Pedraza-Chaverrí, J; Rincón-Sánchez, AR; Rivas-Estilla, AM, 2005) |
| "Pioglitazone treatment was introduced at various time points." | 1.33 | Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats. ( Horsmans, Y; Leclercq, IA; Sempoux, C; Stärkel, P, 2006) |
| " These results indicated that chronic administration of S." | 1.33 | Water-soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. ( Chang, HH; Chiu, JH; Lee, TY; Lin, HC; Wang, GJ; Yang, YY, 2006) |
| "No curcumin was given to one group of the model rats and it served as the control." | 1.33 | [Prophylactic effect of curcumin on hepatic fibrosis and its relationship with activated hepatic stellate cells]. ( Fang, L; He, YJ; Lü, X; Sheng, Y; Shu, JC, 2006) |
| "kg(-1) twice a week; IL-10 treated group (E): besides same dosage of CCl(4) given, intraperitoneal injection with IL-10 4 ug." | 1.32 | Effects of transmitters and interleukin-10 on rat hepatic fibrosis induced by CCl4. ( Chen, ZX; Huang, YH; Li, B; Li, D; Wang, XZ; Zhang, LJ, 2003) |
| "We analyzed the effects of protein deficiency on liver Cu, Fe, Zn, Mn, and Se in carbon tetrachloride (CCl4)-induced liver cirrhosis, the relation of protein undernutrition and these trace elements with the activity of some hepatic antioxidative enzymatic mechanisms, and the relation of all of them with morphological and biochemical changes in 40 male adult Sprague-Dawley rats divided in four groups." | 1.32 | Effects of protein deficiency on liver trace elements and antioxidant activity in carbon tetrachloride-induced liver cirrhosis. ( Abreu-González, P; Galindo-Martín, L; González-Reimers, E; López-Lirola, A; Martínez-Riera, A; Olivera, RM; Sánchez-Sanchez, JJ; Santolaria-Fernández, F, 2003) |
| "Thalidomide + CCl(4) treated rats showed minor histological alterations and thinner bands of collagen." | 1.32 | Thalidomide ameliorates carbon tetrachloride induced cirrhosis in the rat. ( Fernández-Martínez, E; García, J; Lara-Ochoa, F; Muriel, P; Pérez-Alvarez, V; Ponce, S; Shibayama, M; Tsutsumi, V, 2003) |
| "Transforming growth factor beta1 (TGF-beta1) is a pleiotropic cytokine, which displays potent profibrogenic effects and is highly expressed in fibrotic livers." | 1.32 | A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. ( Blanco, G; Borrás-Cuesta, F; Bustos, M; Castilla-Cortázar, I; Dotor, J; Ezquerro, IJ; Greenwel, P; Lasarte, JJ; Lechuga, Mdel C; Peñuelas, I; Prieto, J; Rodríguez, C; Rojkind, M, 2003) |
| "Candesartan cilexetil treatment significantly reduced the fibrosis development." | 1.32 | Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis. ( Bayram, I; Ozbek, H; Tuncer, I; Ugras, S, 2003) |
| "Throughout different stages of liver fibrosis, leptin immunoreactivity was localized in activated hepatic stellate cells only, whereas immunoreactivity for the receptor was mainly seen on hepatocytes." | 1.32 | Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. ( Bornstein, SR; Fölsch, UR; Kloehn, S; Mönig, H; Otte, C; Otte, JM; Strodthoff, D, 2004) |
| "Perindopril treatment significantly reduced mean fibrosis score, messenger RNA and protein levels of AT1 receptor, protein levels of TGF-beta1 and PDGF-BB, Serum levels of HA and LN, and MMP-2 activity." | 1.32 | [Perindopril attenuates the progression of CCl4-inducing rat hepatic fibrosis]. ( Li, X; Meng, Y; Wu, PS; Yang, XS; Zhang, ZS; Zou, JL, 2004) |
| "Portal hypertension was successfully induced in 15 dogs." | 1.32 | [Morphology of portal hypertension at the early stage of liver damage induced by CCl4: an experimental study with dogs]. ( Wei, YW; Xue, DB; Zhang, RP; Zhang, WH, 2004) |
| "Carbon tetrachloride is a hepatotoxic agent which generates haloalkane radicals during its biotransformation in the liver and is widely used to make the experimental model of hepatic damage." | 1.32 | Effects of selenium on histopathological and enzymatic changes in experimental liver injury of rats. ( Aksoy, N; Bitiren, M; Karakilçik, AZ; Musa, D; Ozardali, I; Zerin, M, 2004) |
| "Carbon tetrachloride was injected subcutaneously to the mice in the latter 3 groups every 3 days for 1 month." | 1.32 | [Protective effects of bicyclol on liver fibrosis induced by carbon tetrachloride]. ( Li, Y; Liu, GT, 2004) |
| "In bleomycin-induced pulmonary fibrosis, there is increased expression of alpha8beta1 by interstitial fibroblasts, the majority of which coexpress alpha smooth muscle actin, a marker of tissue myofibroblasts." | 1.31 | Expression of the integrin alpha8beta1 during pulmonary and hepatic fibrosis. ( Breuss, JM; Fallon, JT; Levine, D; Milner, TA; Rockey, DC; Schnapp, LM, 2000) |
| "In summary, osteopenia characterized by loss of bone mass and preserved bone composition was found in rats with advanced cirrhosis induced by CCl4 and phenobarbital in drinking water." | 1.31 | Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrhosis. ( Castilla-Cortázar, I; Cemborain, A; Delgado, G; Díaz-Sánchez, M; García, M; Muguerza, B; Picardi, A, 2000) |
| "Bile duct ligation resulted in biliary cirrhosis; CYP1A, CYP2C and CYP3A content was decreased and the caffeine, aminopyrine, and erythromycin breath tests were reduced whereas CYP2E1 content and the nitrosodimethylamine breath test were unchanged compared with controls." | 1.31 | Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis. ( Bastien, MC; Leblond, F; Pichette, V; Villeneuve, JP, 2000) |
| " Chronic administration of CCl(4) (10 weeks) induced a cirrhotic state, characterized by increased liver fibronectin and collagen types I and III content, enhanced expression of alpha-1 (I) collagen mRNA, portal hypertension, and liver dysfunction." | 1.31 | Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats. ( De Sánchez, VC; Díaz-Muñoz, M; Hernández-Muñoz, R; López, V; Sánchez-Sevilla, L; Suárez-Cuenca, JA; Trejo-Solís, C; Yáñez, L, 2001) |
| " Chronic administration of AG did not modify significantly any parameter in cirrhotic and control animals." | 1.31 | [Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites]. ( Atucha, NM; Eleno, N; Fortepiani, LA; García-Estañ, J; López-Novoa, JM; Martínez-Salgado, C; Ortiz, MC, 2001) |
| "To realize the roles of peripheral vasodilatation and atrial natriuretic peptide in the formation of cirrhotic ascites, the effects of long-term administration of octreotide on carbon tetrachloride-induced cirrhotic rats were evaluated." | 1.30 | Effects of long-term administration of octreotide on sodium retention and atrial natriuretic peptide in carbon tetrachloride-induced cirrhotic rats. ( Chao, Y; Chen, CC; Chien, CH; Hwu, CM; Lee, FY; Lee, SD; Tsai, YT; Wang, PS; Wang, SS; Wu, SL, 1997) |
| "The carbon tetrachloride-treated rats were randomly assigned to three groups: no treatment, Salvia for 12 weeks from the onset of carbon tetrachloride treatment, and Salvia for 2 weeks after the completion of the 10-week course." | 1.30 | Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. ( Ang, HK; Ho, JM; Tan, CE; Wasser, S, 1998) |
| "As phenobarbital also has a hepatotrophic effect, its role in liver regeneration following partial hepatectomy (HTX) is not elucidated." | 1.30 | Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration. ( Hashimoto, M; Kothary, PC; Raper, SE, 1999) |
| "Acute pancreatitis was induced by the closed duodenal loop (CDL) method, immediately after which PGE1 (60 ng/kg/min) was infused intravenously via the jugular vein." | 1.30 | Exacerbation of acute pancreatitis in the presence of chronic liver injury in rats, with special reference to therapeutic efficacy of prostaglandin E1. ( Imamura, M; Mikami, Y; Takahashi, H; Yamauchi, H, 1999) |
| "In experimental models of liver fibrosis, CTGF accumulated in parallel with the development of septal fibrosis and cirrhosis." | 1.30 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis. ( Ba, N; Bedossa, P; Dargere, D; De Gouville, AC; Gauthier, JM; Huet, S; Martinez, V; Paradis, V; Ratziu, V; Sobesky, R; Vidaud, M, 1999) |
| " As the result, the urinary excretion of Nam, N1-methyl-4-pyridone-3-carboxamide (4-Py), Nam + N1-methylnicotinamide (MNA) + N1-methyl-2-pyridone-5-carboxamide (2-Py) + 4-Py was lower in the CCl4-treated groups than in the non-treated group (control) regardless of the experimental period (1 mo and 2 mo) or dosing amount of CCl4 (0." | 1.30 | Tryptophan-niacin metabolism in liver cirrhosis rat caused by carbon tetrachloride. ( Egashira, Y; Isagawa, A; Komine, T; Ohta, T; Sanada, H; Shibata, K; Yamada, E, 1999) |
| "Nuclear localization was found in biliary cirrhosis only." | 1.29 | Differential effect of micronodular and biliary cirrhosis on epidermal growth factor receptor expression in the rat. ( Marti, U; Oguey, D; Reichen, J, 1994) |
| "Theophylline (3 mg/kg) was administered intravenously on two separate occasions, 24 hours apart, during which time the rats breathed either room air or oxygen (95%) from 1 hour before dosing until the end of plasma sampling with a randomized order of gas exposure." | 1.29 | Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats. ( Angus, PW; Hickey, PL; McLean, AJ; Morgan, DJ, 1995) |
| "Adenosine treatment to CCl4-poisoned rats was able to counteract the effect of the hepatotoxin on the redox equilibrium; hence, it could be linked to the beneficial action of the nucleoside in the maintenance of mitochondrial function." | 1.29 | Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R, 1994) |
| "Captopril-pretreated rats with cirrhosis had a significantly higher RBF (+26%) and 24-hour urinary sodium excretion (+52%) but no significant differences in GFR and SNGFR compared to cirrhotic rats without captopril pretreatment." | 1.29 | Renal effects of atrial natriuretic peptide in cirrhotic rats with and without captopril pretreatment. ( Brabant, G; Brunkhorst, R; Koch, KM; Malcharzik, C; Wrenger, E, 1993) |
| "Lactic acidosis has been described in patients with liver disease." | 1.29 | Colchicine alters lactate utilization in isolated hepatocytes of rats treated with CCl4 and ethanol. ( Barrio, E; Cutrín, C; Meniño, MJ; Parafita, MA; Vieira, R, 1993) |
| "Antipyrine extraction was decreased by 90% in acute liver injury, compared with 33% in cirrhosis, suggesting a much greater reduction of microsomal enzyme activity in the former group." | 1.29 | Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat. ( Fenyves, D; Gariépy, L; Villeneuve, JP, 1993) |
| "Since portal hypertension affects the gastric mucosa, leading to congestive gastropathy and thus to increased incidence of bleeding, it is one of the possible causes of increased permeability of gastric mucosal capillaries." | 1.29 | Increased capillary endothelial leakage in portal hypertensive gastric mucosa: fluorescence microscopy in CCl4-induced cirrhotic rats. ( Aletras, H; Eleftheriadis, E; Karkavelas, G; Kotzampassi, K; Papadimitriou, C, 1995) |
| "Chronic damage to liver parenchyma was induced in rabbits by the long-term administration of carbon tetrachloride." | 1.29 | Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). III. Chronic CCl4-induced liver damage with eventual cirrhosis in rabbits. ( Bieńkiewicz, M; Kapuściński, J; Kuroszczyk, J; Liniecki, J; Tuszyner, K, 1995) |
| " This increase was abolished by chronic administration of N(omega)-nitro-L-arginine methyl ester." | 1.29 | Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. ( Ginés, P; Martin, PY; McMurtry, I; Morris, K; Niederberger, M; Schrier, RW; Tsai, P, 1996) |
| "All carbon tetrachloride-treated rats had cirrhosis at the end of the study." | 1.29 | Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. ( Alonso, E; Caballería, J; Cabré, M; Camps, J; Deulofem, R; Gassó, M; Giménez, A; Mato, JM; Pajares, M; Parés, A; Rodés, J; Rubio, M; Varela, G, 1996) |
| "Adenosine treatment of CCl4-poisoned rats partially prevented the alterations in mitochondria membrane composition and prevented, almost completely, the impairment of mitochondria function induced by CCl4." | 1.28 | Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R, 1992) |
| "A common model for producing experimental liver cirrhosis is the administration of CCl4 to phenobarbital (PhB)-stimulated rats." | 1.28 | Liver cirrhosis in rats: regeneration and assessment of the role of phenobarbital. ( Ahren, B; Alumets, J; Bengmark, S; Foss, A; Jeppsson, B; Rozga, J, 1991) |
| "Rats treated with carbon tetrachloride showed such changes in internal conditions as the following: mild inflammatory alterations, tendency to anemia, severe liver-cell injury, and liver dysfunction." | 1.28 | [A study on erythrocyte-membrane osmotic resistance and periodontal changes in rats treated with carbon tetrachloride]. ( Fujita, K, 1990) |
| " No significant side effects were observed, despite a long-term administration of the acyclic retinoid." | 1.28 | Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats. ( Kato, M; Moriwaki, H; Muto, Y; Noma, A; Nozaki, Y; Okuno, M; Suzuki, Y; Tagaya, O, 1990) |
| " Reversibility of cirrhosis was dosage dependent; complete recovery occurred in the low- but not the high-dose group by Day 15." | 1.28 | Assessment of hepatic indicators of subchronic carbon tetrachloride injury and recovery in rats. ( Allis, JW; Seely, JC; Simmons, JE; Ward, TR, 1990) |
| "Tegafur (FT) is a masked compound of 5-fluorouracil (5-FU) and supposed to be activated in the liver." | 1.28 | [Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction]. ( Imai, S; Nio, Y; Ohgaki, K; Shiraishi, T; Tobe, T, 1989) |
| "Propranolol-treated rats had significantly lower cardiac output (-31%) and heart rate (-26%) than controls (p less than 0." | 1.28 | Propranolol decreases portal pressure without changing portocollateral resistance in cirrhotic rats. ( Bosch, J; de Lacy, AM; Kravetz, D; Pizcueta, MP; Rodés, J, 1989) |
| "Colchicine treatment reversed almost completely the alterations." | 1.27 | Heterogeneity of changes on the disposition of aspirin in rats with CCl4-induced chronic liver damage. ( Amezcua, JL; Favari, L; Mourelle, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 166 (18.02) | 18.7374 |
| 1990's | 239 (25.95) | 18.2507 |
| 2000's | 252 (27.36) | 29.6817 |
| 2010's | 236 (25.62) | 24.3611 |
| 2020's | 28 (3.04) | 2.80 |
| Authors | Studies |
|---|---|
| Lafoz, E | 1 |
| Campreciós, G | 1 |
| García-Calderó, H | 2 |
| Anton, A | 1 |
| Vilaseca, M | 2 |
| Ruart, M | 1 |
| Guasch, E | 1 |
| Garrabou, G | 1 |
| Delgado, TC | 1 |
| Martínez-Chantar, ML | 3 |
| García-Martínez, R | 1 |
| Gracia-Sancho, J | 4 |
| Hernández-Gea, V | 2 |
| García-Pagán, JC | 6 |
| Skurikhin, EG | 1 |
| Afanas'ev, SA | 1 |
| Zhukova, MA | 1 |
| Rebrova, TY | 1 |
| Muslimova, EF | 1 |
| Pan, ES | 1 |
| Ermakova, NN | 1 |
| Pershina, OV | 1 |
| Pakhomova, AV | 1 |
| Putrova, OD | 1 |
| Sandrikina, LA | 1 |
| Kogai, LV | 1 |
| Dygai, AM | 1 |
| Faccioli, LAP | 1 |
| Dias, ML | 1 |
| Paranhos, BA | 1 |
| Dos Santos Goldenberg, RC | 1 |
| Wu, JC | 1 |
| Chen, R | 3 |
| Luo, X | 2 |
| Li, ZH | 1 |
| Luo, SZ | 1 |
| Xu, MY | 1 |
| Ge, MX | 1 |
| Liu, HT | 1 |
| Zhang, N | 1 |
| Niu, WX | 1 |
| Lu, ZN | 1 |
| Bao, YY | 1 |
| Huang, R | 3 |
| Yu, DK | 1 |
| Shao, RG | 1 |
| He, HW | 1 |
| Zhang, B | 6 |
| Ji, LH | 1 |
| Zhang, CG | 2 |
| Zhao, G | 2 |
| Wu, ZY | 3 |
| Kurahashi, T | 1 |
| Yoshida, Y | 3 |
| Ogura, S | 2 |
| Egawa, M | 2 |
| Furuta, K | 2 |
| Hikita, H | 1 |
| Kodama, T | 1 |
| Sakamori, R | 1 |
| Kiso, S | 3 |
| Kamada, Y | 3 |
| Wang, IC | 1 |
| Eguchi, H | 1 |
| Morii, E | 1 |
| Doki, Y | 1 |
| Mori, M | 1 |
| Kalinichenko, VV | 1 |
| Tatsumi, T | 1 |
| Takehara, T | 2 |
| Hammoutene, A | 1 |
| Biquard, L | 1 |
| Lasselin, J | 1 |
| Kheloufi, M | 1 |
| Tanguy, M | 1 |
| Vion, AC | 1 |
| Mérian, J | 1 |
| Colnot, N | 1 |
| Loyer, X | 1 |
| Tedgui, A | 1 |
| Codogno, P | 1 |
| Lotersztajn, S | 2 |
| Paradis, V | 2 |
| Boulanger, CM | 1 |
| Rautou, PE | 1 |
| Zhao, J | 3 |
| Han, M | 2 |
| Zhou, L | 3 |
| Liang, P | 2 |
| Wang, Y | 14 |
| Feng, S | 1 |
| Lu, H | 3 |
| Yuan, X | 2 |
| Han, K | 1 |
| Chen, X | 7 |
| Liu, S | 4 |
| Cheng, J | 1 |
| She, S | 1 |
| Wu, X | 4 |
| Zheng, D | 1 |
| Pei, X | 2 |
| Ma, J | 2 |
| Sun, Y | 4 |
| Zhou, J | 3 |
| Nong, L | 1 |
| Guo, C | 1 |
| Lv, P | 4 |
| Song, Q | 1 |
| Zheng, C | 1 |
| Liang, W | 1 |
| Huang, S | 1 |
| Li, Q | 3 |
| Liu, Z | 6 |
| Song, Z | 1 |
| Li, Y | 12 |
| Zhang, Y | 8 |
| Kong, W | 1 |
| You, H | 3 |
| Xi, J | 1 |
| Zhang, S | 4 |
| Liu, H | 3 |
| Yin, M | 1 |
| Hausser, A | 1 |
| Ishikawa, E | 1 |
| Yamasaki, S | 1 |
| Jin, ZG | 1 |
| Sharma, A | 1 |
| Verma, AK | 1 |
| Kofron, M | 1 |
| Kudira, R | 1 |
| Miethke, A | 1 |
| Wu, T | 3 |
| Wang, J | 9 |
| Gandhi, CR | 6 |
| Mejias, M | 1 |
| Gallego, J | 1 |
| Naranjo-Suarez, S | 1 |
| Ramirez, M | 1 |
| Pell, N | 1 |
| Manzano, A | 1 |
| Suñer, C | 1 |
| Bartrons, R | 1 |
| Mendez, R | 1 |
| Fernandez, M | 3 |
| Huang, Y | 3 |
| Lou, A | 1 |
| Wang, GZ | 1 |
| Hu, Y | 1 |
| Huang, W | 1 |
| Zhu, X | 3 |
| Chen, T | 2 |
| Lin, J | 2 |
| Meng, Y | 3 |
| Li, X | 12 |
| Karpińska, G | 1 |
| Dobrowolski, JC | 1 |
| Yinda, CK | 1 |
| Rector, A | 1 |
| Zeller, M | 1 |
| Conceição-Neto, N | 1 |
| Heylen, E | 1 |
| Maes, P | 1 |
| Ghogomu, SM | 1 |
| Van Ranst, M | 1 |
| Matthijnssens, J | 1 |
| Arthanari, SK | 1 |
| Vanitha, J | 1 |
| Ganesh, M | 1 |
| Venkateshwaran, K | 1 |
| de Lama Caro-Patón, G | 1 |
| García-Salido, A | 1 |
| Iglesias-Bouzas, MI | 1 |
| Guillén, M | 1 |
| Cañedo-Villaroya, E | 1 |
| Martínez-Romera, I | 1 |
| Serrano-González, A | 1 |
| Casado-Flores, J | 1 |
| Gale, P | 2 |
| Li, H | 7 |
| Lucero-Prisno, DE | 1 |
| Abdullah, AS | 1 |
| Huang, J | 3 |
| Laurence, C | 1 |
| Liang, X | 1 |
| Ma, Z | 1 |
| Mao, Z | 1 |
| Ren, R | 1 |
| Wu, S | 1 |
| Wang, N | 4 |
| Wang, P | 4 |
| Wang, T | 6 |
| Yan, H | 1 |
| Zou, Y | 2 |
| Olsen, KM | 1 |
| Gabler, NK | 1 |
| Rademacher, CJ | 1 |
| Schwartz, KJ | 1 |
| Schweer, WP | 1 |
| Gourley, GG | 1 |
| Patience, JF | 1 |
| Rauch, JC | 1 |
| Stokes, RS | 1 |
| Shike, DW | 1 |
| Luebbe, KM | 1 |
| Stalker, LA | 1 |
| Klopfenstein, TJ | 1 |
| Funston, RN | 1 |
| Unger, PA | 1 |
| Lighaam, LC | 1 |
| Vermeulen, E | 1 |
| Kruithof, S | 1 |
| Makuch, M | 1 |
| Culver, EL | 1 |
| van Bruggen, R | 1 |
| Remmerswaal, EBM | 1 |
| Ten Berge, IJM | 1 |
| Emmens, RW | 1 |
| Niessen, HWM | 1 |
| Barnes, E | 1 |
| Wolbink, GJ | 1 |
| van Ham, SM | 1 |
| Rispens, T | 1 |
| Liang, JX | 1 |
| Liu, J | 8 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| The Role of Microbiome Reprogramming on Liver Fat Accumulation[NCT03914495] | 57 participants (Actual) | Interventional | 2019-05-21 | Terminated (stopped due to PI carefully considered multiple factors and decided to close study to any further enrollment.) | |||
| A Phase 2 Trial of N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy[NCT03499249] | Phase 2 | 16 participants (Anticipated) | Interventional | 2018-05-18 | Active, not recruiting | ||
| Phase 1/2 Study of Human Menstrual Blood-derived Mesenchymal Stem Cells Transplantation for the Evaluation of the Efficacy and Safety in Patients With Liver Cirrhosis[NCT01483248] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2010-10-31 | Enrolling by invitation | ||
| Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia[NCT03395028] | Early Phase 1 | 6 participants (Actual) | Interventional | 2018-01-15 | Completed | ||
| Galectin-3 as a Predictor for Thromboembolic Formation in Patients With Non Valvular Atrial Fibrillation Assessed by CHA₂DS₂-VASc Scoring[NCT03413072] | 140 participants (Anticipated) | Observational | 2018-06-30 | Not yet recruiting | |||
| Impact of Implementing a Nurse Caring Behavior Protocol on Postoperative Cardiac Patient Satisfaction: A Randomized Controlled Trial[NCT05446844] | 60 participants (Actual) | Interventional | 2019-10-01 | Completed | |||
| A Phase 1, Randomised, Double-Blind, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of XFB-19 in Healthy Adult Volunteers[NCT05361733] | Phase 1 | 40 participants (Anticipated) | Interventional | 2022-08-05 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for carbon tetrachloride and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Liver cirrhosis: An overview of experimental models in rodents.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis; Liver Cirrhosis, Expe | 2022 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Ligation; Liver Cirrhosis, Experimental; Rats; Time Facto | 2012 |
[Hepatorenal syndrome in view of experimental studies].
Topics: Animals; Carbon Tetrachloride; Hepatorenal Syndrome; Humans; Kidney; Kidney Failure, Chronic; Liver | 2002 |
Targeted treatments for cirrhosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Differentiati | 2004 |
Autologous bone marrow cell infusion therapy for liver cirrhosis.
Topics: Albumins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differ | 2008 |
Animal models of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Experimental; Liver Diseases | 1993 |
Prevention and treatment of liver fibrosis based on pathogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Cytochrome P-450 CYP2E1; Fat Emulsions, In | 1999 |
Cirrhosis of the liver: a reversible disease?
Topics: Animals; Carbon Tetrachloride; Collagen; Diet; Ethionine; Female; Humans; Liver; Liver Cirrhosis; Li | 1979 |
Hepatocyte swelling and portal hypertension.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatomegaly; Hypertension, Portal; Liver; Li | 1992 |
[The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Topics: Animals; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Penici | 1990 |
The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Extracellular Matrix; Female; Fibronectins; Laminin; Liver; | 1985 |
3 trials available for carbon tetrachloride and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development.
Topics: Adult; Aged; Animals; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Carbon Tetrachloride Pois | 2013 |
Gender different response to immunonutrition in liver cirrhosis with sepsis in rats.
Topics: Animals; Carbon Tetrachloride; Diet; Female; Interleukin-10; Interleukin-1beta; Interleukin-6; Liver | 2012 |
907 other studies available for carbon tetrachloride and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats.
Topics: Animals; Caloric Restriction; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Energy I | 2021 |
Age-Related Features of the Viscosity of Plasma and Mitochondrial Membranes of Hepatocytes in Liver Cirrhosis.
Topics: Age Factors; Animals; Carbon Tetrachloride; Cell Membrane; Ethanol; Hepatocytes; Liver; Liver Cirrho | 2021 |
MicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cohort Studies; Down-Regulation; G1 Ph | 2019 |
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.
Topics: Animals; Carbon Tetrachloride; Cell Line; Common Bile Duct; Gene Expression Regulation; Hepatic Stel | 2020 |
Gender differences in vascular reactivity of mesenteric arterioles in portal hypertensive and non-portal hypertensive rats.
Topics: Animals; Arterioles; Carbon Tetrachloride; Female; Gonadal Steroid Hormones; Humans; Hypertension, P | 2019 |
Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cells, Cultured; Chemokine CCL2; Disease M | 2020 |
A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis.
Topics: Adult; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carbon Tetrachloride; Cells, Cult | 2020 |
TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways.
Topics: Adenine; Alanine; Animals; Antiviral Agents; Carbon Tetrachloride; Disease Models, Animal; DNA-Bindi | 2020 |
PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Polarity; C | 2020 |
Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Progression; Hepatic Stellate Cells; Humans; | 2020 |
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against Decapentaplegic, and CCAAT/Enhancer-Binding Protein C/EBP Transcription Factors.
Topics: Animals; Carbon Tetrachloride; CCAAT-Enhancer-Binding Protein-delta; Cell Transdifferentiation; Cell | 2020 |
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Gene Expression Regulation; Gene Knockdown Techniques; Gly | 2020 |
Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS.
Topics: Angiotensin-Converting Enzyme 2; Animals; Antioxidants; Autophagy; Carbon Tetrachloride; Cells, Cult | 2020 |
Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells.
Topics: Animals; Carbon Tetrachloride; Cholestasis; Female; Fibroblasts; Hedgehog Proteins; Humans; Liver; L | 2020 |
Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Capsaicin; Carbon Tetrachloride; Cell Line; Cell Proliferation; C | 2020 |
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2021 |
SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling.
Topics: Animals; Benzamides; Carbon Tetrachloride; Cell Line; Dioxoles; Disease Models, Animal; Drug Liberat | 2020 |
Codonopis bulleynana Forest ex Diels (cbFeD) effectively attenuates hepatic fibrosis in CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Chemota | 2021 |
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Topics: AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Ind | 2021 |
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2021 |
Hepatoprotective Impact of Geraniol Against CCl
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemica | 2020 |
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl
Topics: Amygdalin; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; Cell Proliferation; C | 2021 |
Branched-chain amino acids and l-carnitine attenuate lipotoxic hepatocellular damage in rat cirrhotic liver.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Carnitine; Cell Death; Chemical and Drug | 2021 |
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2021 |
RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; CRISPR-Cas S | 2021 |
Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer-Associated Fibroblasts Formed After Chronic Liver Injuries.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Cancer-Associated Fibroblasts; Ca | 2021 |
Inhibition of the transient receptor potential vanilloid 3 channel attenuates carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdow | 2021 |
Single-Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell-Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice.
Topics: Animals; Carbon Tetrachloride; Cell Lineage; Cells, Cultured; Gene Expression Regulation; Gene Knock | 2021 |
Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Interleukin-6; Ligation; Liver Cirrhosis, Bil | 2017 |
Fermented milk containing Lactobacillus paracasei subsp. paracasei CNCM I-1518 reduces bacterial translocation in rats treated with carbon tetrachloride.
Topics: Animals; Bacterial Translocation; beta-Defensins; Carbon Tetrachloride; Dysbiosis; Fermentation; Gas | 2017 |
Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical and Drug | 2018 |
Role of growth factor receptor-bound 2 in CCl
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Live | 2017 |
Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical a | 2017 |
Mosapride Stabilizes Intestinal Microbiota to Reduce Bacterial Translocation and Endotoxemia in CCl
Topics: Animals; Bacterial Translocation; Benzamides; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2017 |
Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Bacterial Translocation; Carbon Tetrachloride; | 2018 |
Thymosin β4 attenuates liver fibrosis via suppressing Notch signaling.
Topics: Animals; Carbon Tetrachloride; Cell Line; Down-Regulation; Gene Expression; Hepatic Stellate Cells; | 2017 |
S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Typ | 2018 |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Down-Regulation; End Stage Liver Disease; Endothelia | 2017 |
Chinese herbal formula Fuzheng Huayu alleviates CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2B1; Cyto | 2018 |
Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling.
Topics: Actins; Animals; Autophagy; Bacterial Translocation; Carbon Tetrachloride; Cells, Cultured; Collagen | 2017 |
Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl
Topics: Acetates; Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Antioxidants; Biomarkers | 2018 |
Abrogation of carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats by Ajwa date fruit extract through ameliorating oxidative stress and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2017 |
Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats: Hepatoprotection at molecular level.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytoprotection; Inf | 2018 |
Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl
Topics: Antioxidants; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Q | 2018 |
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Topics: Acetaminophen; Aged; Animals; Carbon Tetrachloride; Case-Control Studies; Female; Hematopoietic Stem | 2019 |
Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2018 |
Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; | 2018 |
Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Cytopr | 2018 |
The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Becaplermin; Carbon Tetrach | 2018 |
Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; D | 2018 |
DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; DNA (Cytosine-5-)- | 2018 |
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-catenin signalling pathway.
Topics: Animals; Carbon Tetrachloride; Disease Progression; Drug Synergism; Drug Therapy, Combination; Hepat | 2018 |
Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Carbamates; Carbon Tetrachloride; Cell Count; Cells, C | 2019 |
Potentials of Differentiated Human Cord Blood-Derived Unrestricted Somatic Stem Cells in Treatment of Liver Cirrhosis.
Topics: Adult Stem Cells; Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferatio | 2019 |
Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultu | 2019 |
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Typ | 2019 |
γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Drug Evaluation, Preclinical; Garcinia mangostana; Gene Kn | 2019 |
Expression of Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and CD147 in the Traditional Chinese Medicine "Compound T11" for Treatment of Chronic Liver Injury.
Topics: Animals; Basigin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose | 2019 |
Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Dependovirus; Down-Regulation; Extracellular Matrix; Female; Gene Exp | 2019 |
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Collagen T | 2018 |
Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Typ | 2019 |
SVIP alleviates CCl
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Survival; Disease Models, Animal; Hep G2 Cells; Hepat | 2019 |
Dimethylfumarate ameliorates hepatic injury and fibrosis induced by carbon tetrachloride.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen T | 2019 |
Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl
Topics: Acyltransferases; Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Proteins; Carbon Tetrachlo | 2019 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas | 2021 |
Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clodronic Acid; Collagen Type | 2019 |
Phase-contrast computed tomography: A correlation study between portal pressure and three dimensional microvasculature of ex vivo liver samples from carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computed Tomography Angiograp | 2019 |
MANF regulates splenic macrophage differentiation in mice.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Humans; Liver Cirrhosis, Experimental; Macropha | 2019 |
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy.
Topics: Animals; B7-H1 Antigen; Carbon Tetrachloride; Cell Line, Tumor; Disease Progression; Female; Gene Tr | 2019 |
Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cell Line; Extracellular Matrix; Gene Knockdown Techniques; Hepatic S | 2019 |
The Therapeutic Mechanisms of Propolis Against CCl
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Cytokines; Hepatic Stellate Ce | 2019 |
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug | 2019 |
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2019 |
Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling.
Topics: Animals; Carbon Tetrachloride; Cell Line; Enzyme Inhibitors; Hepatic Stellate Cells; Indoleamine-Pyr | 2019 |
Symbiotic formulation in experimentally induced liver fibrosis in rats: intestinal microbiota as a key point to treat liver damage?
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Cytokines | 2013 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
Regeneration of cirrhotic liver in rabbits after intrahepatic injection of cryoprecipitate.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Factor VIII; Fibrinogen; Hepatocytes; Liver; Live | 2013 |
Dietary supplementation of blueberry juice enhances hepatic expression of metallothionein and attenuates liver fibrosis in rats.
Topics: Actins; Animals; Beverages; Blueberry Plants; Carbon Tetrachloride; Collagen Type III; Dietary Suppl | 2013 |
Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Dose-Response Relationship, Drug; Fla | 2013 |
Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.
Topics: Adult; Aged; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette | 2013 |
Association of age-dependent liver injury and fibrosis with immune cell populations.
Topics: Age Factors; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced L | 2013 |
Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats.
Topics: Adult; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Carbon Tetrachloride; Dose-Response Rela | 2013 |
CHOP-mediated hepcidin suppression modulates hepatic iron load.
Topics: Animals; Carbon Tetrachloride; CCAAT-Enhancer-Binding Protein-alpha; Female; Gene Expression Regulat | 2013 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced chronic injury in rats.
Topics: Alanine Transaminase; Animals; Aprotinin; Aspartate Aminotransferases; Carbon Tetrachloride; Chemica | 2013 |
Protective effect of the herbal medicine Gan‑fu‑kang against carbon tetrachloride‑induced liver fibrosis in rats.
Topics: Actins; Animals; beta Catenin; Biomarkers; Carbon Tetrachloride; Collagen Type I; Collagen Type III; | 2013 |
Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Diet, High-Fat; Dysbiosis; Gastrointestinal | 2014 |
Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Caspase 3; Hepatocyte Growth Factor; Hepatocytes; | 2013 |
Effects of Fufang Biejia Ruangan pills on hepatic fibrosis in vivo and in vitro.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Cell C | 2013 |
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Stellate Cells; Hepatitis; Humans; Liver Cirrhosis, Experimen | 2014 |
Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis.
Topics: Animals; Antihypertensive Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chro | 2013 |
Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Drug Therapy, Combination; Fatty Acids, Omega-3; | 2014 |
[Effect of shuganjianpifang on the expression of BCL-2 and BAX in rats livers with hepatic fibrosis].
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; C | 2013 |
Hepatorenal syndrome: insights into the mechanisms of intra-abdominal hypertension.
Topics: Albumins; Animals; Biomarkers; Blood Urea Nitrogen; Carbon Tetrachloride; Creatinine; Hepatorenal Sy | 2013 |
Protective effect of Bifidobacterium pseudocatenulatum CECT7765 against induced bacterial antigen translocation in experimental cirrhosis.
Topics: Animals; Antigens, Bacterial; Bacterial Translocation; Bifidobacterium; Carbon Tetrachloride; DNA, B | 2014 |
[Compound nutrients promote liver rehabilitation and regeneration in rats with CCl4;-induced liver cirrhosis].
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Gene Expression Regulation; Hepatocyte Growth Factor; | 2013 |
Role of gap junctions modulating hepatic vascular tone in cirrhosis.
Topics: Acetylcholine; Animals; Carbon Tetrachloride; Common Bile Duct; Connexins; Dose-Response Relationshi | 2014 |
Activity of glycogen synthase and glycogen phosphorylase in normal and cirrhotic rat liver during glycogen synthesis from glucose or fructose.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Fructose; Glucose; Glucose Intolerance; Glycogen; Glyco | 2014 |
Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis.
Topics: Animals; Biomarkers; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; C | 2014 |
[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Colchicine; Cytokines; Disease Models, Animal; Gene Expression Regula | 2013 |
Vascular endothelial growth factor promotes fibrosis resolution and repair in mice.
Topics: Adenoviridae; Animals; Antibodies, Neutralizing; Apoptosis; Bile Ducts; Capillary Permeability; Carb | 2014 |
Liposomal oxymatrine in hepatic fibrosis treatment: formulation, in vitro and in vivo assessment.
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chemistry, Pharmaceutical; Cytoprotection; Dimethylnitrosa | 2014 |
Hepatopulmonary syndrome: the role of intra-abdominal hypertension and a novel mouse model.
Topics: Albumins; Alkalosis, Respiratory; Animals; Blood Gas Analysis; Carbon Tetrachloride; Hepatopulmonary | 2014 |
Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats.
Topics: Allyl Compounds; Animals; Carbon Tetrachloride; Collagen; Hepatic Stellate Cells; Liver; Liver Cirrh | 2014 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Dr | 2014 |
Hydroxysafflor yellow A suppresses liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chalcone; Diet, High-Fat; Down-Regulation; Enzyme- | 2014 |
Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Fibrosis; Liver Cirrhosis, Experimen | 2014 |
VSL#3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Ascites; Bacterial Translocation; Carbon Tetrachloride; Disease Models, Animal; Intestinal | 2015 |
Establishment of a liver fibrosis model in cynomolgus monkeys.
Topics: Animals; Biopsy; Carbon Tetrachloride; Disease Progression; Hepatocytes; Liver; Liver Cirrhosis, Exp | 2014 |
Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cichorium intybus; Cytoprotection; Dose-Res | 2014 |
Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2014 |
Mest attenuates CCl4-induced liver fibrosis in rats by inhibiting the Wnt/β-catenin signaling pathway.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Cells, Cultured; Hepatic Stellate Cells; Liver Cirrhosi | 2014 |
Differential effect of liver cirrhosis on the pregnane X receptor-mediated induction of CYP3A1 and 3A2 in the rat.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Gene Express | 2014 |
Prostacyclin decreases splanchnic vascular contractility in cirrhotic rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterioles; Carbon Tetrachloride; Cyclic AMP-Dependent Protei | 2014 |
Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Carbon Tetrachloride; | 2014 |
Bacterial translocation and endotoxemia after pringle maneuver in cirrhotic rats.
Topics: Animals; Bacterial Translocation; Blood Loss, Surgical; Carbon Tetrachloride; Constriction; Digestiv | 2015 |
Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice.
Topics: Actins; Adiponectin; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Collagen; Disease | 2014 |
Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats.
Topics: Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2014 |
Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression.
Topics: Actins; Adenoviridae; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain | 2014 |
A study of free portal pressure in cynomolgus monkeys with different degrees of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Macaca fascicularis; Male; Portal Pres | 2014 |
Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice.
Topics: Adult; Adult Stem Cells; Alanine Transaminase; Alginates; Animals; Aspartate Aminotransferases; Bile | 2015 |
Mesenchymal stem cells mitigate cirrhosis through BMP7.
Topics: Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Cells, Cultured; Gene Expression Regula | 2015 |
Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cult | 2015 |
[Effect of alcohol extract of Plumula Nelumbini on carbon tetrachloride induced rat liver fibrosis: an experimental study].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Ethanol; Hepat | 2014 |
Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cytokines; Hepatic Stellate Cells; Inflamma | 2015 |
Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cardiomyopathies; Cardiotonic Agents; Cyclodextrins; Flava | 2015 |
Protective effects of Ocimum gratissimum polyphenol extract on carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Lipid Peroxidation; Liv | 2015 |
Anti-fibrotic effect of plumbagin on CCl₄-lesioned rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachlorid | 2015 |
The carbon tetrachloride model in mice.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; European Union; Guidelines as Topic; Humans; | 2015 |
Caffeic acid phenethyl ester inhibits liver fibrosis in rats.
Topics: Alcohol Drinking; Animals; Antioxidants; Biomarkers; Caffeic Acids; Carbon Tetrachloride; Chemical a | 2015 |
Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Diethylnitrosamine; Gene Expression Profiling; Gene | 2016 |
Contrast-enhanced ultrasound for quantitative assessment of portal pressure in canine liver fibrosis.
Topics: Animals; Area Under Curve; Biopsy; Blood Flow Velocity; Blood Pressure Determination; Carbon Tetrach | 2015 |
Preventative effects of prostaglandin E1 in combination with iodized olive oil on liver fibrosis after transcatheter arterial chemoembolization in a rabbit model of CCl4-induced liver fibrosis.
Topics: Alanine Transaminase; Alprostadil; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachlo | 2015 |
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Caspase 3; Chemical an | 2015 |
Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, | 2016 |
Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytopro | 2015 |
IGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats.
Topics: Animals; Apoptosis; Caco-2 Cells; Carbon Tetrachloride; Claudin-1; Endotoxins; Humans; Hypertension, | 2015 |
Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2015 |
Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Topics: Acetylation; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbamates; Carbon Tetrachloride; Ce | 2015 |
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Cell Transdifferentiation; Cells, Cul | 2015 |
Activation of Slit2-Robo1 signaling promotes liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cell Line; Cells, Cultured; Female; Hepatic Ste | 2015 |
Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats.
Topics: Animals; Artemisinins; Artesunate; Body Weight; Carbon Tetrachloride; Drugs, Chinese Herbal; Endotox | 2015 |
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Topics: alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers, Tumor; Carbon Tetrachloride; Carcinogens; Cell | 2015 |
Yiguanjian decoction and its ingredients inhibit angiogenesis in carbon tetrachloride-induced cirrhosis mice.
Topics: Actins; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Hyd | 2015 |
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; | 2015 |
The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Cell Line, Tumor; Cytochrome P-450 CYP2E1; Cytokines; Disease Progres | 2016 |
Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-β1.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type III; Down-Regulation; Extracellular Matrix; Imm | 2015 |
Transplantation of mesenchymal stem cells expressing TIMP-1-shRNA improves hepatic fibrosis in CCl₄-treated rats.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Disease Models, Animal; Genetic Therapy; Genetic V | 2015 |
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation.
Topics: Adenoviridae; Animals; Apoptosis; Carbon Tetrachloride; Catalytic Domain; Cell Proliferation; Collag | 2015 |
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2016 |
Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.
Topics: Aminopropionitrile; Animals; Carbon Tetrachloride; Collagen; Collagen Type I; Collagen Type I, alpha | 2016 |
Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Catechols; Chemic | 2016 |
Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.
Topics: Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; Ge | 2016 |
Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 2016 |
The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis.
Topics: Animals; Carbon Tetrachloride; DNA; Fatty Liver, Alcoholic; Female; Interferon-gamma; Liver Cirrhosi | 2016 |
Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway.
Topics: Adenoviridae; Animals; beta Catenin; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induce | 2016 |
Protective Effect of Gallotannin-Enriched Extract Isolated from Galla Rhois against CCl₄-Induced Hepatotoxicity in ICR Mice.
Topics: Animals; Antioxidants; Aphids; Apoptosis; Apoptosis Regulatory Proteins; Biological Products; Biomar | 2016 |
Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis.
Topics: Animals; Anti-Inflammatory Agents; Artemisinins; Artesunate; Bacteria; Bacterial Translocation; Carb | 2016 |
New role and molecular mechanism of Gadd45a in hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Cycle Proteins; Cells, Cultured; Collagen Type I; Hepati | 2016 |
Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Carbon Tetrachloride; Citrus; Dietary Fiber; Dietary S | 2016 |
Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites.
Topics: Animals; Aquaporin 2; Ascites; Benzazepines; Carbon Tetrachloride; Colon; Diarrhea; Dose-Response Re | 2016 |
New mechanism in the modulation of carbon tetrachloride hepatotoxicity in rats using different natural antioxidants.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Drug | 2016 |
Comparative study of antifibrotic activity of some magnesium-containing supplements on experimental liver toxicity. Molecular study.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Dietary Supplements; Female; Liver; Liver C | 2017 |
Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycl | 2016 |
Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.
Topics: Action Potentials; Animals; Carbon Tetrachloride; Cardiomyopathies; Cardiotonic Agents; Chemical and | 2016 |
Antifibrotic effect of meloxicam in rat liver: role of nuclear factor kappa B, proinflammatory cytokines, and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2016 |
Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Conne | 2016 |
Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Immunity, Innate; Interferon Type I; Interle | 2017 |
Hepatic cirrhosis and recovery as reflected by Raman spectroscopy: information revealed by statistical analysis might lead to a prognostic biomarker.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Data Interpretation, Statistical; Liver; Liver Cirrhosis, | 2016 |
Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hepatic Stellate Cells; | 2016 |
Suppression of MicroRNA-219-5p Activates Keratinocyte Growth Factor to Mitigate Severity of Experimental Cirrhosis.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Carbon Tetrachloride; Female; Fibroblast Growth Fac | 2016 |
Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carthamus tinctori | 2017 |
Mesenchymal Stem Cells with Enhanced Bcl-2 Expression Promote Liver Recovery in a Rat Model of Hepatic Cirrhosis.
Topics: Animals; Antigens; Biomarkers; Carbon Tetrachloride; Cell Shape; Disease Models, Animal; Gene Expres | 2016 |
Effects of Nuclear Factor-E2-related factor 2/Heme Oxygenase 1 on splanchnic hemodynamics in experimental cirrhosis with portal hypertension.
Topics: Animals; Arterioles; Carbon Tetrachloride; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemodyna | 2017 |
Enhanced actions of insulin-like growth factor-I and interferon-alpha co-administration in experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Drug Therapy, Combination; Insulin-Like Growth Factor I; Interferon-a | 2009 |
Ischemic preconditioning and intermittent clamping confer protection against ischemic injury in the cirrhotic mouse liver.
Topics: Animals; Carbon Tetrachloride; Constriction; Ischemic Preconditioning; Liver; Liver Cirrhosis, Exper | 2008 |
Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Carbon Tetrachloride; Cynara scolymus; Glutathion | 2008 |
Potent antioxidant role of pirfenidone in experimental cirrhosis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachl | 2008 |
[Morphometry of hepatocyte mitochondrial apparatus in normal and cirrhotic rat liver].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chronic Disease; H | 2008 |
[Effect of peptide YY on hepatic fibrosis in rats].
Topics: Animals; Carbon Tetrachloride; Immunohistochemistry; Liver Cirrhosis, Experimental; Male; Peptide YY | 2008 |
The effect of terguride in carbon tetrachloride-induced liver fibrosis in rat.
Topics: Actins; Animals; Blood Chemical Analysis; Carbon Tetrachloride; Female; Immunohistochemistry; Lisuri | 2008 |
Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; Carbon Tetrach | 2008 |
Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation.
Topics: Animals; Ascites; Carbon Tetrachloride; Common Bile Duct; Disease Progression; Hypertension, Portal; | 2008 |
Senescence of activated stellate cells limits liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cellular Senescence; Female; Fibroblasts; Humans; Ki | 2008 |
Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type | 2008 |
Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Humans; Hydroxyproline; Image Processing, C | 2008 |
Nitric oxide and vascular remodeling modulate hepatic arterial vascular resistance in the isolated perfused cirrhotic rat liver.
Topics: Adrenergic alpha-Agonists; Animals; Bile Ducts; Carbon Tetrachloride; Dose-Response Relationship, Dr | 2008 |
Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Blotting, Western; Carbon Tetrach | 2008 |
Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Endothelium, Vascular; Gene Transfer Techniques; Geneti | 2009 |
Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis.
Topics: Analgesics; Anesthesia; Animals; Biopsy; Blood Flow Velocity; Carbon Tetrachloride; Dose-Response Re | 2008 |
Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Esophageal and Gastric Varices; Hypertension, Portal; Liver Cirrhosis | 2009 |
Development of a new animal model of liver cirrhosis in swine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats.
Topics: Administration, Oral; Animals; Apoptosis; Carbon Tetrachloride; Drugs, Chinese Herbal; Hepatic Stell | 2009 |
[Curative effect of interferon-alpha on rat liver fibrosis induced by CCl4].
Topics: Actins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Collagen Type I; Interferon-a | 2008 |
Inhibition of carbon tetrachloride-mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Glutathione Pero | 2008 |
Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatectomy; Liver Cirrhosis, Experimental; M | 2008 |
Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis.
Topics: Albumins; Animals; Azo Compounds; Bone Marrow Transplantation; Carbon Tetrachloride; Central Nervous | 2008 |
An ultrasound and histomorphological analysis of experimental liver cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Ethanol; Female; Fluorescent Antibody Technique; Liver Cirrhosis, Exp | 2008 |
Embryonic stem cells reduce liver fibrosis in CCl4-treated mice.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Collagen; Embryonic Stem Cells; Female; Green F | 2008 |
An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Ligation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosi | 2008 |
Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease.
Topics: Animals; Aryldialkylphosphatase; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemo | 2009 |
Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis.
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Cardiac Output; Diuresis; Dose-Response Rela | 2009 |
Retinoid metabolism in the small intestine during development of liver cirrhosis.
Topics: Alcohol Oxidoreductases; Animals; Biomarkers; Carbon Tetrachloride; Chromatography, High Pressure Li | 2009 |
[Prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts].
Topics: Animals; Biomarkers; Body Weight; Carbon Tetrachloride; Collagen Type III; Drugs, Chinese Herbal; Hy | 2008 |
The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Dose-Response Relationship, Drug; Fermentation; Hydr | 2009 |
Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Copper; Female; Hepatolenticular Dege | 2009 |
[Effect of aspartame on the liver cirrhosis model induced by the complex factors].
Topics: Animals; Aspartame; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Liver; Liver Cirrhosis, E | 2009 |
N-acetylcysteine prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver C | 2009 |
Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Cell- and Tissue-Based Therapy; Fetal Bloo | 2009 |
Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide.
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain; Hepatic Stellate Cel | 2009 |
Suppression of carbon tetrachloride-induced liver fibrosis by transplantation of a clonal mesenchymal stem cell line derived from rat bone marrow.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line, Tumor; | 2009 |
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati | 2009 |
[Establishment of liver fibrosis in rabbit model and quantitative study on hepatic perfusion with dynamic whole-liver 3D MR imaging].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Image Interpretation, Computer-Assisted; Imag | 2009 |
Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent (99m)Tc-mebrofenin.
Topics: Aniline Compounds; Animals; ATP-Binding Cassette Transporters; Carbon Tetrachloride; Glycine; Imino | 2009 |
Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Collagen; Gene Expression; Liver Cirrhosis, Experi | 2009 |
[Syndrome identification of CCl4 induced liver fibrosis model rats based on syndrome detecting from recipe used].
Topics: Animals; Carbon Tetrachloride; Diagnosis, Differential; Drugs, Chinese Herbal; Liver Cirrhosis, Expe | 2009 |
[Effects of transforming growth factor beta 3 on the histopathology and expression of collagen I in experimental hepatic fibrotic rats].
Topics: Animals; Carbon Tetrachloride; Collagen Type I; Dependovirus; Disease Models, Animal; Genetic Therap | 2009 |
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.
Topics: Animals; Antigens, CD; Apoptosis; Cadherins; Carbon Tetrachloride; Caspase 3; Cells, Cultured; Cyclo | 2009 |
Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; | 2009 |
Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride-induced liver fibrosis model.
Topics: Alanine Transaminase; Animals; Aorta, Abdominal; Carbon Tetrachloride; Genotype; Hyperemia; Hyperten | 2009 |
Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Computational Biology; Hepatic Stellate Cells; Liver Cirrh | 2009 |
In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force.
Topics: Animals; Carbon Tetrachloride; Collagen; Elasticity; Elasticity Imaging Techniques; Feasibility Stud | 2009 |
Alterations in mechanical properties of mesenteric resistance arteries in experimental portal hypertension.
Topics: Animals; Biomechanical Phenomena; Blood Pressure; Carbon Tetrachloride; Elasticity; Hypertension, Po | 2009 |
Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Adhesion; Cell Differen | 2009 |
Helicobacter pylori promotes hepatic fibrosis in the animal model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Calcium-Binding Proteins; Ca | 2009 |
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Epith | 2009 |
A novel model of CCl4-induced cirrhosis with ascites in the mouse.
Topics: Administration, Inhalation; Animals; Ascites; Carbon Tetrachloride; Cytokines; Disease Models, Anima | 2009 |
QUANTITATIVE STUDY OF COLLAGEN CONTENT IN EXPERIMENTAL CIRRHOSIS.
Topics: Animals; Carbon Tetrachloride; Collagen; Liver Cirrhosis; Liver Cirrhosis, Experimental; Rats | 1947 |
Antifibrotic effects of ZK14, a novel nitric oxide-donating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCl4-induced hepatic fibrosis.
Topics: Animals; Apoptosis; Biphenyl Compounds; Carbon Tetrachloride; Caspase 3; Caspase 9; Cell Line; Dose- | 2010 |
[Prevention of CC14-induced liver fibrosis by Periplaneta americana extract].
Topics: Animals; Carbon Tetrachloride; Collagen; Hyaluronic Acid; Laminin; Liver; Liver Cirrhosis, Experimen | 2009 |
Effects of Danggui Buxue Decoction () on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats.
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Hepatic Stellate Cells; Lipid Peroxidation; Li | 2009 |
CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis.
Topics: Animals; Blood Platelets; Carbon Tetrachloride; Chemotaxis; Hepatic Stellate Cells; Hepatitis C; Hum | 2010 |
[Effects of Smad4 on liver fibrosis and hepatocarcinogenesis in mice treated with CCl4/ethanol].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Liver Cirrhosis, Experimenta | 2010 |
Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Glucose; Insulin; Insulin Resistance; Insulin Secretion; | 2010 |
[Observation on experimental liver fibrosis and hepatic carcinogenesis of HBV gene knock-in transgenic mice induced by CCl4/ethanol].
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Ethanol; Female; Gene Knock-In Techniques; He | 2010 |
Potential protective effects of a traditional Chinese herb, Litsea coreana Levl., on liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Electrop | 2010 |
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachlo | 2010 |
Combinatorial gene therapy renders increased survival in cirrhotic rats.
Topics: Adenoviridae; Animals; Base Sequence; Carbon Tetrachloride; DNA Primers; Gene Expression; Genetic Th | 2010 |
Vascular corrosion casting: analyzing wall shear stress in the portal vein and vascular abnormalities in portal hypertensive and cirrhotic rodents.
Topics: Animals; Carbon Tetrachloride; Corrosion Casting; Hypertension, Portal; Liver; Liver Cirrhosis, Expe | 2010 |
Intestinal flora imbalance results in altered bacterial translocation and liver function in rats with experimental cirrhosis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; Bifidobacterium; Carbon Tetrachloride; Endo | 2010 |
Bee venom inhibits hepatic fibrosis through suppression of pro-fibrogenic cytokine expression.
Topics: Actins; Alanine Transaminase; Animals; Apitherapy; Aspartate Aminotransferases; Bee Venoms; Carbon T | 2010 |
[Effects of blueberry on the expression patterns of heme oxygenase-1 in rats with hepatic fibrosis].
Topics: Animals; Blueberry Plants; Carbon Tetrachloride; Drugs, Chinese Herbal; Heme Oxygenase (Decyclizing) | 2010 |
Diffusion tensor imaging of liver fibrosis in an experimental model.
Topics: Animals; Carbon Tetrachloride; Diffusion Tensor Imaging; Liver; Liver Cirrhosis, Experimental; Male; | 2010 |
[Effect of Xiaozheng Rongmu powder for the treatment of liver cirrhosis in rats].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Liver Cirrhosis, Experimental; Male; Phytother | 2010 |
The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Down-Regulation; Hepatic Stellate Cells; Liposomes; Liver C | 2011 |
Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Choline Deficiency; C | 2011 |
Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver.
Topics: Animals; Carbon Tetrachloride; Endothelium, Vascular; Gene Expression Regulation; Hemodynamics; Hydr | 2011 |
A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice.
Topics: Active Transport, Cell Nucleus; Alkadienes; Animals; Carbon Tetrachloride; Carbon Tetrachloride Pois | 2011 |
Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; | 2011 |
Chinese medicinal herbs in treating model rats with hepatic fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Drugs, | 2009 |
Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse.
Topics: Amnion; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Female; Hepa | 2011 |
N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D.
Topics: Actins; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Carbon Tet | 2011 |
Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Tetrachloride; Dihydrouracil Dehy | 2011 |
Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice.
Topics: Animals; Axl Receptor Tyrosine Kinase; Carbon Tetrachloride; Cell Proliferation; Choline Deficiency; | 2011 |
Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4.
Topics: Animals; Aspirin; Blotting, Western; Carbon Tetrachloride; Cell Nucleus; Chronic Disease; Collagen; | 2012 |
Attenuated liver fibrosis after bile duct ligation and defective hepatic stellate cell activation in neural cell adhesion molecule knockout mice.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Cell Separation; Cells, Cultured; Cholesta | 2011 |
Role of angiotensin-1 receptor blockade in cirrhotic liver resection.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Biomarkers; Carbo | 2011 |
Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Animals; Bile Ducts; Biomarkers; Blotting, Western; Carbon Tetrachloride; Epit | 2011 |
[Effect of interferon-α on rat liver fibrosis induced by CCl(4)].
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Hepatic Stellate Cells; Interferon-a | 2011 |
[Effects of Chinese herbal medicine Yinchenhao Decoction on expressions of apoptosis-related genes in dimethylnitrosamine- or carbon tetrachloride-induced liver cirrhosis in rats].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carbon Tetrachloride; Caspase 3; Drug | 2011 |
NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Collage | 2011 |
NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation.
Topics: Animals; Carbon Tetrachloride; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclin-Depe | 2011 |
Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Analysis of Variance; Animals; Carbon Tetrachloride; Con | 2011 |
[Effects of Chinese herbal medicine Yiguanjian Decoction on collagen metabolism of hepatic tissues in rats with CCl4-induced liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Liver; Liver Cirrhosis, Experimental | 2011 |
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
Topics: Amino-Acid N-Acetyltransferase; Animals; Blotting, Western; Carbon Tetrachloride; Cell Nucleus; Chro | 2011 |
Effects of Shugan-Huayu powder, a traditional Chinese medicine, on hepatic fibrosis in rat model.
Topics: Actins; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; | 2010 |
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.
Topics: Acute Disease; Animals; Aptamers, Nucleotide; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultur | 2012 |
[Chinese herbal medicine Xiayuxue Decoction inhibits liver angiogenesis in rats with carbon tetrachloride-induced liver fibrosis].
Topics: Actins; Animals; Carbon Tetrachloride; CD55 Antigens; Drugs, Chinese Herbal; Liver; Liver Cirrhosis, | 2011 |
11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Carbon Tetrachloride; Cytochrome P-450 Enzym | 2011 |
Preparation and evaluation of hepatic stellate cell selective, surface conjugated, peroxisome proliferator-activated receptor-gamma ligand loaded liposomes.
Topics: Albumins; Animals; Biological Availability; Biomarkers; Carbon Tetrachloride; Drug Delivery Systems; | 2012 |
(Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury.
Topics: Alanine Transaminase; Aldehyde Reductase; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical a | 2012 |
Liver fibrosis protects mice from acute hepatocellular injury.
Topics: Acute Disease; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Int | 2012 |
Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats.
Topics: 2-Acetylaminofluorene; Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Car | 2012 |
Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74.
Topics: AMP-Activated Protein Kinases; Animals; Antigens, Differentiation, B-Lymphocyte; Carbon Tetrachlorid | 2011 |
A novel marker for assessment of liver matrix remodeling: an enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M).
Topics: Animals; Bile Ducts; Biomarkers; Bone Neoplasms; Breast Neoplasms; Carbon Tetrachloride; Collagen Ty | 2011 |
ED50 and recovery times after propofol in rats with graded cirrhosis.
Topics: Alanine Transaminase; Anesthetics, Intravenous; Animals; Aspartate Aminotransferases; Biomarkers; Ca | 2012 |
Imatinib mesylate improves liver regeneration and attenuates liver fibrogenesis in CCL4-treated mice.
Topics: Animals; Apoptosis; Benzamides; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, | 2012 |
Insights antifibrotic mechanism of methyl palmitate: impact on nuclear factor kappa B and proinflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Cytokines; Liver; | 2012 |
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proli | 2012 |
Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Movement; Chimer | 2012 |
Prevention of fibrosis progression in CCl4-treated rats: role of the hepatic endocannabinoid and apelin systems.
Topics: Animals; Apelin; Apelin Receptors; Apoptosis; Blood Pressure; Cannabinoid Receptor Modulators; Carbo | 2012 |
Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Denaturing Gradient Gel Electrophoresis; End | 2011 |
Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl(4)-induced advanced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular M | 2012 |
Morphological and biomechanical remodeling of the hepatic portal vein in a swine model of portal hypertension.
Topics: Animals; Biomechanical Phenomena; Carbon Tetrachloride; Compliance; Down-Regulation; Elastic Modulus | 2012 |
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Elastin; Liver; Liver Cirrhosis, Experimental; Macrophages; Matrix Me | 2012 |
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related | 2012 |
Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cytoglobin; Embryo, Mammalian; Endothelin-1; Female; Hepa | 2012 |
Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Disease Models, Animal; Fatty Liver; Female | 2012 |
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carcinoma, | 2012 |
Sulfasalazine prevents the increase in TGF-β, COX-2, nuclear NFκB translocation and fibrosis in CCl4-induced liver cirrhosis in the rat.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrach | 2012 |
Therapeutic potential of mesenchymal stem cells overexpressing human forkhead box A2 gene in the regeneration of damaged liver tissues.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, Cultured; Chem | 2012 |
[Dynamic change of lipid peroxidation-related protein expression and the intervention effects of Yiguanjian decoction in a rat model of CCl4-induced liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Lipid Peroxidation; Liver Cirrhosis, Experimen | 2012 |
The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor.
Topics: Adaptive Immunity; Animals; Apoptosis; Camphanes; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; | 2012 |
Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Image Processing, Computer-Assisted; Liver; Li | 2012 |
Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Disease Progression; Gene Expression Regul | 2012 |
Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats.
Topics: Actins; Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2012 |
Effect of recombinant human growth hormone and interferon gamma on hepatic collagen synthesis and proliferation of hepatic stellate cells in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type I | 2012 |
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.
Topics: Animals; Bile Ducts; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Line; Collagen Type I; | 2012 |
Hydroxysafflor yellow A attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting ERK5 signaling.
Topics: Actins; Animals; Carbon Tetrachloride; Carthamus; Chalcone; Chemical and Drug Induced Liver Injury; | 2012 |
Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl₄-treated mice.
Topics: Actins; Administration, Oral; Albumins; alpha-Fetoproteins; Animals; Antigens, Differentiation; Biom | 2012 |
Lactobacillus johnsonii La1 without antioxidants does not decrease bacterial translocation in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Antioxidants; Bacterial Translocation; Carbon Tetrachloride; Lactobacillus; Liver Cirrhosis | 2012 |
Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model.
Topics: Animals; Blood Vessels; Carbon Tetrachloride; Caveolins; Cell Proliferation; Endothelial Cells; Endo | 2013 |
Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease.
Topics: Amino Acids, Branched-Chain; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carb | 2012 |
Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Benzopyrans; Butoxamine; Carbon Tetrachloride; DNA, | 2012 |
Erythropoietin decreases carbon tetrachloride-induced hepatic fibrosis by inhibiting transforming growth factor-beta.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Erythropoietin; Fibronectins; Hepatic Stellate Cells | 2012 |
The therapeutic effects of tectorigenin on chemically induced liver fibrosis in rats and an associated metabonomic investigation.
Topics: Animals; Carbon Tetrachloride; Collagen; Dose-Response Relationship, Drug; Glutathione Peroxidase; I | 2012 |
Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chondroitin Sulfate Proteoglycans; Col | 2012 |
Inhibitory effects of salvianolic acid B on CCl(4)-induced hepatic fibrosis through regulating NF-κB/IκBα signaling.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzofurans; Bilirubin; Carbon Tetrachlo | 2012 |
Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2013 |
[The anti-portal hypertension effect of oleanolic acid in CCl4-induced cirrhosis rats].
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Liver; Liv | 2012 |
Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Dru | 2013 |
A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.
Topics: Acetylation; Angiogenesis Inhibitors; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Depsipept | 2013 |
Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Body Weight; Carbon Tetrachloride; Ca | 2013 |
Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Re | 2013 |
High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis.
Topics: Animals; Bile; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Collagen; Diet; Liver; Li | 2002 |
In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats.
Topics: Animals; Blotting, Far-Western; Carbon Tetrachloride; Endothelium, Vascular; Gene Transfer Technique | 2002 |
Potentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in rats.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Enzyme Inhibitors; Liver Cirrhosis, Experimental; Mal | 2002 |
Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Collagenases; Hepatocytes; Kinetics; Live | 2003 |
Rats made cirrhotic by chronic CCl4 treatment still exhibit anticipatory activity to a restricted feeding schedule.
Topics: Animals; Biological Clocks; Body Weight; Carbon Tetrachloride; Circadian Rhythm; Drinking Behavior; | 2002 |
[Effects of panax notoginseng saponins on the expression of tumor necrosis factor alpha and secretion phospholipase A2 in rats with liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Ginsenosides; Liver; Liver Cirrhosis, Experimental; Mal | 2003 |
The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats.
Topics: Animals; Astragalus propinquus; Carbon Tetrachloride; Collagen Type I; Drugs, Chinese Herbal; Hydrox | 2003 |
Intestinal mucosal oxidative damage and bacterial translocation in cirrhotic rats.
Topics: Animals; Bacterial Translocation; Biomarkers; Carbon Tetrachloride; Cecum; Enterococcus faecalis; En | 2003 |
Iron overload enhances the development of experimental liver cirrhosis in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Iron Carbonyl Compounds; Iron Overl | 2003 |
Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration.
Topics: Animals; Carbon Tetrachloride; Cytokines; Drug Administration Schedule; Leptin; Liver; Liver Cirrhos | 2003 |
Hepatic osteodystrophy in rats results mainly from portasystemic shunting.
Topics: Absorptiometry, Photon; Animals; Bone Density; Carbon Tetrachloride; Disease Models, Animal; Female; | 2003 |
Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Cordyceps; D | 2003 |
Effects of transmitters and interleukin-10 on rat hepatic fibrosis induced by CCl4.
Topics: Angiotensin II; Animals; Calcitonin Gene-Related Peptide; Carbon Tetrachloride; Endothelins; Epopros | 2003 |
[Influence of Cordyceps sinensis on pancreatic islet beta cells in rats with experimental liver fibrogenesis].
Topics: Animals; Carbon Tetrachloride; Cordyceps; Female; Insulin; Insulin Secretion; Islets of Langerhans; | 2003 |
A combination of Ang II and carbon tetrachloride accelerates process of hepatic fibrosis.
Topics: Alanine Transaminase; Angiotensin II; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Li | 2003 |
Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis.
Topics: Activin Receptors, Type II; Animals; Apoptosis; Carbon Tetrachloride; Disease Progression; Gene Expr | 2003 |
Reduction in hepatic endothelin-1 clearance in cirrhosis.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Endothelin-1; Liver; Liver Cirrhosis, Experimental; M | 2003 |
Effects of protein deficiency on liver trace elements and antioxidant activity in carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Diet; Glutathione Peroxidase; Lipid Peroxidation; Liver | 2003 |
[Therapeutic effects of octreotide on hepatofibrosis-induced with carbon tetrachloride in rats].
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type III; Hyaluronic Acid; Laminin; | 2003 |
AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4).
Topics: Animals; Base Sequence; Carbon Tetrachloride; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hydrox | 2003 |
[Effects of glycyrrhizin on genes expression during the process of liver fibrosis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Gene Expression Regulation; | 2003 |
Thalidomide ameliorates carbon tetrachloride induced cirrhosis in the rat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Drug Evaluation, Preclini | 2003 |
A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury.
Topics: Amino Acid Sequence; Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Molecular Sequenc | 2003 |
[Action of lipocaic in experimental liver cirrhosis induced by carbon tetrachloride and its effect on the so-called regeneration following lobectomy in cirrhotic livers].
Topics: Animals; Carbon Tetrachloride; Lipotropic Agents; Liver; Liver Cirrhosis, Experimental; Regeneration | 1952 |
[Effect of cortisone on the development of experimental cirrhosis by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Cortisone; Liver Cirrhosis, Experimental | 1953 |
[Carbon tetrachloride cirrhosis and restoration of the liver].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver Cirrhosis; Liver Cirrhos | 1953 |
[Effect of adenylpyrophosphate on liver cirrhosis due to CCl4 and on regenerative capacity of liver in this disease].
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Liver | 1954 |
Effect of cortisone on carbon tetrachloride cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Cortisone; Fibrosis; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1954 |
[Effect of ACTH on experimental carbon tetrachloride cirrhosis].
Topics: Adrenocorticotropic Hormone; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Ci | 1954 |
A study of the effects of the surgical treatment of experimentally produced liver disease.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatitis; Hypertension; Liver Cirrho | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Effect of the antidiuretic hormone on carbon tetrachloride induced cirrhosis in rats].
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1956 |
[Increased growth in rats with liver lesions induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Growth; Liver Cirrhosis, Experimental; Rats | 1956 |
[Increased growth in rats with liver lesions induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Growth; Liver Cirrhosis, Experimental; Rats | 1956 |
[Increased growth in rats with liver lesions induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Growth; Liver Cirrhosis, Experimental; Rats | 1956 |
[Increased growth in rats with liver lesions induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Growth; Liver Cirrhosis, Experimental; Rats | 1956 |
[Electrophoretic data on blood proteins in CCl4-induced cirrhosis in albino rats].
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Humans; Liver Cirrhos | 1957 |
[Chemical and histochemical aspects of the development of connective tissue in carbon tetrachloride-induced experimental cirrhosis in rats].
Topics: Animals; Carbon Tetrachloride; Connective Tissue; Liver Cirrhosis, Experimental; Rats | 1957 |
[Histochemical localization and chemical determination of the alkaline phosphatase activity of the liver in cirrhosis caused by carbon tetrachloride in white rats].
Topics: Alkaline Phosphatase; Animals; Biological Phenomena; Carbon Tetrachloride; Liver Cirrhosis; Liver Ci | 1957 |
[Histochemical picture and acid phosphatase activity of the liver in cirrhosis caused by carbon tetrachloride in white rats].
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; Pho | 1957 |
[Effect of splenectomy on experimental liver cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Spleen; Splenectomy | 1958 |
[Effect of administration of estrogens on experimental carbon tetrachloride cirrhosis in rats].
Topics: Animals; Carbon Tetrachloride; Estradiol Congeners; Estrogens; Liver Cirrhosis, Experimental; Rats | 1957 |
[Interference of 5-hydroxytryptamine with the development of experimental cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Serotonin; Serotonin Agents | 1958 |
Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis.
Topics: Actins; Amides; Animals; Carbon Tetrachloride; Enzyme Inhibitors; Infusion Pumps, Implantable; Infus | 2003 |
[Influence of several hormones on the morphological behavior of the rat pituitary and adrenal glands during experimental liver cirrhosis induced by carbon tetrachloride].
Topics: Adrenal Glands; Animals; Carbon Tetrachloride; Hormones; Leadership; Liver Cirrhosis, Experimental; | 1960 |
[Effect of experimental liver cirrhosis and of CC1-4 intoxication on glucuronic transferase activity in rat livers].
Topics: Animals; Carbon Tetrachloride; Glucuronosyltransferase; Humans; Liver; Liver Cirrhosis, Experimental | 1961 |
Inhibition of experimental cirrhosis by carbon tetrachloride following treatment with aminoacetonitrile.
Topics: Aminoacetonitrile; Animals; Carbon Tetrachloride; Cyanides; Liver Cirrhosis, Experimental | 1961 |
Liver regeneration after partial hepatectomy in carbon tetrachloride-induced cirrhosis in the rat.
Topics: Animals; Carbon Tetrachloride; Digestion; Hepatectomy; Liver; Liver Cirrhosis; Liver Cirrhosis, Expe | 1961 |
[Methods of induction in rabbits of cirrhosis of the liver with splenomegaly and ascites by means of carbon tetrachloride].
Topics: Animals; Ascites; Carbon Tetrachloride; Lagomorpha; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1960 |
[Hepatic oxytoxinases in the course of experimental cirrhosis induced by carbon tetrachloride in the rabbit].
Topics: Animals; Carbon Tetrachloride; Endopeptidases; Hydrolases; Liver Cirrhosis, Experimental; Oxytocin; | 1961 |
[Studies on the hormonal treatment of chronic liver diseases. Note V. Action of cortisone acetate on the histological and histochemical picture and on the hexosamine and hydroxyproline content of the cirrhotic liver (carbon tetrachloride-induced)].
Topics: Amino Sugars; Animals; Carbon Tetrachloride; Cortisone; Hexosamines; Hydroxyproline; Liver Cirrhosis | 1959 |
[Experimental cirrhosis induced by carbon tetrachloride. Effects of hormone treatment].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Prednisolone; Testosterone | 1959 |
[Cell respiration of hepatic tissue in experimental cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Cell Respiration; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1959 |
[Histochemical changes in carbon tetrachloride-induced cirrhosis of rats after partial hepatectomy].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver Cirrhosis; Liver C | 1962 |
[Morphological and functional phases of development of experimental liver cirrhosis under the influence of carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1962 |
Cell proliferation and fiber formation in chronic carbon tetrachloride intoxication. A morphologic and chemical study.
Topics: Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Hepatitis; Liver Cirrho | 1963 |
[Studies on therapeutic alteration of experimental liver cirrhosis in rats. III. Carbon tetrachloride cirrhosis in rats and its therapeutic alteration by gluco corticoids with and without simultaneous administration of antibiotics and androgens].
Topics: Adrenal Cortex Hormones; Androgens; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Car | 1963 |
[RESEARCH ON THE PROBLEM OF MODIFICATION OF EXPERIMENTAL LIVER DAMAGE BY CARBON TETRACHLORIDE IN CHICKENS].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1963 |
[THE EFFECT OF MAGNESIUM AND VITAMIN E ON THE ACUTE CARBON TETRACHLORIDE DAMAGE OF THE RAT LIVER].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1963 |
[COLLAGENASE ACTIVITY OF CERTAIN HEPATIC EXTRACTS. ITS CHANGES IN THE CARBON TETRACHLORIDE-POISONED RAT].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1964 |
[STUDIES ON EXPERIMENTAL HEPATIC PATHOLOGY. I. MORPHOPATHOLOGY OF ACUTE POISONING DUE TO CARBON TETRACHLORIDE IN THE SYRIAN GOLDEN HAMSTER].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cricetinae; Kidney; Liver Cirrhosis; | 1964 |
[EFFECT OF PARTIAL HEPATECTOMY ON THE RESTITUTION OF THE ANGIOARCHITECTONICS IN THE LIVER OF RATS WITH CARBON TETRACHLORIDE CIRRHOSIS].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepate | 1964 |
RENAL GLOMERULAR LESIONS AFTER ADMINISTRATION OF CARBON TETRACHLORIDE AND ETHIONINE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Electrons; Ethionine; Kidney Glomerulus; Liver | 1964 |
EFFECT OF DIETARY PROTEIN ON CARBON TETRACHLORIDE-INDUCED HEPATIC FIBROGENESIS IN ALBINO RATS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietar | 1965 |
PORTAL VENOUS PRESSURE IN ACUTE HEPATIC NECROSIS AND EARLY CIRRHOSIS DUE TO CARBON TETRACHLORIDE.
Topics: Blood Pressure; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis; Liver Cirrhos | 1965 |
CHANGES OF MAST CELL POPULATION IN RAT LIVER DURING DEVELOPMENT OF CARBON TETRACHLORIDE-INDUCED CIRRHOSIS.
Topics: Carbon Tetrachloride; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental; Mast Cells; Pathology; | 1965 |
[MINICIONE G, PAGNINI P, GORI F: (DEVELOPMENT OF EXPERIMENTAL CIRRHOSIS FROM CARBON TETRACHLORIDE IN THE "REGENERATED" LIVER OF RATS SUBJECTED TO WIDE HEPATECTOMY)].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver Cirrhosis; Liver C | 1964 |
INFLUENCE OF CARBON TETRACHLORIDE-INDUCED CIRRHOSIS ON THE INCIDENCE OF RESTRAINT-STRESS EROSIONS IN THE STOMACH OF RATS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Fatty Liver; Gastric Mucosa; Incidence; Inject | 1965 |
FIBROGENESIS ALONG THE HEPATIC SINUSOIDS IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS. AN ELECTRON MICROSCOPIC STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1965 |
[Iron deposit in rats with experimental liver cirrhosis (carbon tetrachloride) and enteral iron loading].
Topics: Animals; Carbon Tetrachloride; Hemochromatosis; Iron; Liver Cirrhosis, Experimental; Rats | 1960 |
Carbon tetrachloride cirrhosis in rats. 1. The influence of age, sex, and gonadectomy; 2. The changes in the livers of the fetuses born to mothers exposed to carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Female; Fetus; Humans; Liver Cirrhosis; Liver Cirrhosis, Experimental | 1962 |
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Collagen Type I; DNA-Binding Proteins; Dow | 2003 |
Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2003 |
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Adiponectin; Animals; Becaplermin; Carbon Tetrachlorid | 2003 |
The chalcone butein from Rhus verniciflua shows antifibrogenic activity.
Topics: Animals; Carbon Tetrachloride; Chalcone; Chalcones; Collagen Type I; DNA Primers; Dose-Response Rela | 2003 |
Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Gene Expression Regulation; Immunohistochemistry; | 2004 |
[Perindopril attenuates the progression of CCl4-inducing rat hepatic fibrosis].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2004 |
Histochemical and microchemical changes in experimental cirrhosis and hepatoma formation in mice by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Cirrhosis, Experime | 1951 |
Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Collagen; Culture Media; Disease Models, Animal; Gene E | 2004 |
Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Estradiol; Female; Fibrosis; Hepatocytes; Liver; Liv | 2004 |
High-density lipoproteins reduce the effect of endotoxin on cytokine production and systemic hemodynamics in cirrhotic rats with ascites.
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Cytokines; Endotoxins; Hemodynamics; Injecti | 2004 |
Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Diterpenes; Ginkgolides; Lactones; Liver Cirrhosis, E | 2004 |
Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis.
Topics: Animals; beta-Galactosidase; Carbon Tetrachloride; Cell Line; Cellular Senescence; DNA-Binding Prote | 2004 |
Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Progression; Endothelin Receptor Antagonists; Endothelin-1; H | 2004 |
Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin/STAP as liver fibrogenesis-related markers.
Topics: Animals; Biomarkers; Calcium-Binding Proteins; Carbon Tetrachloride; Cell Count; Cytoglobin; Extrace | 2004 |
[Obstruction of TGF-beta1 signal transduction can decrease the process of hepatocellular carcinoma in mice induced by CCl4/ethanol].
Topics: Adenoviridae; Animals; Antisense Elements (Genetics); Carbon Tetrachloride; Cell Transformation, Neo | 2004 |
[Morphology of portal hypertension at the early stage of liver damage induced by CCl4: an experimental study with dogs].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2004 |
[Comparison of An-Fa-Te with Bie-Jia-Ruan-Gan-Tablet on prevention of liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Cattle; Drugs, Chinese Herbal; Liver; Liver Cirrhosis, Experimental; | 2004 |
Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cholagogues and Choleretics; Drugs, Chinese Herbal; | 2004 |
A role for thrombin in liver fibrosis.
Topics: Actins; Aminopyridines; Animals; Blood Coagulation; Carbon Tetrachloride; Gene Expression Regulation | 2004 |
[Expression of type I inositol 1,4,5-triphosphate receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis].
Topics: Animals; Arterioles; Calcium Channels; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Inosito | 2004 |
Hypoxia potentiates transforming growth factor-beta expression of hepatocyte during the cirrhotic condition in rat liver.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; DNA-Binding Proteins; Hepatocytes; Hypoxia | 2004 |
Effects of selenium on histopathological and enzymatic changes in experimental liver injury of rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2004 |
Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury.
Topics: Actins; Adipocytes; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Female; Fibronectins; | 2005 |
Immunomodulatory effect of oxymatrine on induced CCl4-hepatic fibrosis in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Interle | 2004 |
[Effects of perindopril and valsartan on the expression of TGF beta 1 and TGF beta receptor II mRNA, Smad3 and Smad7 in experimental hepatic fibrotic rats].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poison | 2004 |
[The expression of platelet-derived growth factor (PDGF) receptor-beta and its correlation with extracellular matrix in hepatic tissue in hepatic fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Collagen Type I; Collagen Type III; E | 2004 |
[Effects of combination therapy of rehin and tetramethylpyrazine on experimental hepatic fibrosis induced by tetrachloride].
Topics: Animals; Anthraquinones; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Therapy, Combina | 2004 |
G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Lineage; Cell Mo | 2005 |
Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Epithelial Sodium Channels; Kidney; Liver Cir | 2005 |
[Protective effects of bicyclol on liver fibrosis induced by carbon tetrachloride].
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; DNA-Binding Proteins; Lipid Peroxidation; Liver; | 2004 |
Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver Cirrhosis, Expe | 2005 |
PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage.
Topics: Acute-Phase Proteins; Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced L | 2005 |
Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Colchicine; Collagen; Liv | 2005 |
The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Cyclooxygenase 2 Inhibitors; K | 2005 |
A novel sodium overload test predicting ascites decompensation in rats with CCl4-induced cirrhosis.
Topics: Animals; Ascites; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hemodynamics; Homeostasis; | 2005 |
Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Dose-Response Relationship, Drug; Hydroxypro | 2005 |
Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Glutathione Peroxi | 2005 |
[Effect of antioxidant on hepatic stellate cell proliferation and apoptosis during recovery from liver fibrosis].
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Dietary Supplements; Hep | 2005 |
Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age.
Topics: Aging; Animals; Carbon Tetrachloride; Cells, Cultured; Interferon-alpha; Liver Cirrhosis, Experiment | 2005 |
Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Carbon Tetrachloride; Cycl | 2005 |
[Proteomic analysis of proliferation and apoptosis in carbon tetrachloride induced rat liver fibrosis].
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Caspase 12; Cell Prolifera | 2005 |
[Flk1+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice].
Topics: Animals; Carbon Tetrachloride; Female; Liver Cirrhosis, Experimental; Male; Mesenchymal Stem Cell Tr | 2005 |
Expression of basic fibroblast growth factor in rat liver fibrosis and hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Fibroblast Growth Factor 2; Hepatocytes; Liver; Live | 2005 |
F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen; DNA; Dose-Response Rel | 2005 |
Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.
Topics: Animals; Biomarkers; Biopsy; Carbon Tetrachloride; Disease Models, Animal; Female; Fluorescent Antib | 2005 |
The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2006 |
Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Differentiation; | 2006 |
Retinoid metabolism during development of liver cirrhosis.
Topics: Aging; Animals; Carbon Tetrachloride; Disease Progression; Female; Liver Cirrhosis, Experimental; Ma | 2005 |
Honokiol protects against carbon tetrachloride induced liver damage in the rat.
Topics: Animals; Bilirubin; Biphenyl Compounds; Carbon Tetrachloride; Hepatic Veno-Occlusive Disease; Lignan | 2005 |
Ginkgo biloba extract alleviates liver fibrosis induced by CCl in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen Type I; G | 2005 |
[60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Dose-Response Relationship, Drug; Fullerenes; Liver; Li | 2005 |
[Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Ginkgo biloba; | 2005 |
[Treatment of CCl4 induced chronic liver injury with bone marrow mesenchymal stem cells overexpressing hepatocyte growth factor].
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Differentiati | 2005 |
[Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats].
Topics: Animals; Carbon Tetrachloride; Ginkgolides; Hypertension, Portal; Injections, Intravenous; Lactones; | 2005 |
Insulin-like growth factor I improves intestinal barrier function in cirrhotic rats.
Topics: Animals; Bacterial Translocation; Carbon Tetrachloride; Cells, Cultured; Cyclooxygenase 2; Electric | 2006 |
[Experimental study of liver fibrosis reversal effect of warming-yang compound formula ganzhifu].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Collagen Type I; Collagen Type IV; Dr | 2006 |
Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Methionine A | 2006 |
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Choline; Collagen Type I; Disease Progression; Hypoglycem | 2006 |
Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Carcino | 2006 |
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibroblasts; Galectin 3; Humans; Inflammation; Liver; Liver Cirrhosis | 2006 |
[The changes of advanced glycation end products in a rat liver fibrosis model and the interventional effect of aminoguanidin].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Glycation End Products, Advanced; Gua | 2006 |
[Detecting the activity of antibodies induced by recombinant TGFbeta1 vaccine].
Topics: Animals; Antibodies; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Female; Hepatitis B Core | 2006 |
Cytoglobin overexpression protects against damage-induced fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cytoglobin; Dependovirus; Gene Expression Regulation | 2006 |
Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats.
Topics: Actins; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Carbon Tetrachloride; Drug Sy | 2006 |
Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Dependovirus; Gene Transfer, Horizontal; Genetic Therapy; Heme Oxygen | 2006 |
[Dynamic change of metabolism related protein in liver tissue of rats' model of hepatic fibrosis and regulatory effect of fuzheng huayu decoction on it].
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Hydroxyproline; Liver; Liver Cirrhosis, Experi | 2006 |
[Effects of extracts of Rhizoma curcumae on angiotensin II and its type 1 receptor expression in rat liver fibrosis induced by CCl4].
Topics: Angiotensin II; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Curcuma; Drugs, Chine | 2006 |
Water-soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Carbon Tetrachloride; Caspase 3; Caspase 8; | 2006 |
Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Body Weight; | 2007 |
[Study on pathogenesis of CCl4 induced cirrhosis formation in rats based on the recipe used].
Topics: Animals; Carbon Tetrachloride; Diagnosis, Differential; Drugs, Chinese Herbal; Hydroxyproline; Liver | 2006 |
The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis.
Topics: Adrenomedullin; Animals; Calcitonin Receptor-Like Protein; Carbon Tetrachloride; Gene Expression Reg | 2006 |
Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Disease Models, Animal; Female; Liver Cirrhosis, Experime | 2006 |
[Prophylactic effect of curcumin on hepatic fibrosis and its relationship with activated hepatic stellate cells].
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Curcumin; Enzyme Inhibitor | 2006 |
[The effect of Fuzheng Huayu Decoction on the hepatic proteome during the formation and resolution of rat liver fibrosis].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Liver; Liver C | 2006 |
[Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Lidocaine; Liver; Liver Cirrhosis, Ex | 2006 |
The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis.
Topics: Animals; Biopterins; Carbon Tetrachloride; Endothelium, Vascular; Liver Cirrhosis, Experimental; Mal | 2006 |
Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats.
Topics: Animals; Bile Ducts; Blood Pressure; Carbon Tetrachloride; Hepatorenal Syndrome; Kidney; Ligation; L | 2006 |
Up-regulation of Metabotropic glutamate receptor 3 (mGluR3) in rat fibrosis and cirrhosis model of persistent hypoxic condition.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Hypoxia; Immunohistochemistry; Live | 2007 |
[Effect of prostaglandin E1 on the expression of tissue inhibitor of metalloproteinase-1 in experimental liver fibrosis rats].
Topics: Alprostadil; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Female; Liver Cirrhosis, | 2006 |
The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation.
Topics: Animals; Ascites; Ascitic Fluid; Bacterial Translocation; Carbon Tetrachloride; Cytokines; DNA, Bact | 2006 |
Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Di | 2006 |
Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Down-Regul | 2006 |
Hemodynamic changes with liver fibrosis measured by dynamic contrast-enhanced MRI in the rat.
Topics: Animals; Aorta, Abdominal; Area Under Curve; Carbon Tetrachloride; Contrast Media; Gadolinium DTPA; | 2006 |
Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Desmin; Glutathione Peroxidase; Immunohist | 2006 |
Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; | 2007 |
Expression of mRNAs related to connective tissue metabolism in rat hepatic stellate cells and myofibroblasts.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Connective Tissue; Extracellular Matrix; Fibroblasts | 2007 |
Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain; Dalteparin; | 2007 |
The role of food restriction on CCl4-induced cirrhosis model in rats.
Topics: Animals; Carbon Tetrachloride; Food Deprivation; Kaplan-Meier Estimate; Liver; Liver Cirrhosis, Expe | 2007 |
Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Hyaluronic Acid; Laminin; Liver; Liver Cirrhosi | 2007 |
Bacterial translocation is downregulated by anti-TNF-alpha monoclonal antibody administration in rats with cirrhosis and ascites.
Topics: Animals; Antibodies, Monoclonal; Ascitic Fluid; Bacterial Translocation; Carbon Tetrachloride; Disea | 2007 |
[Experimental study of two histological quantitative methods of hepatic fibrosis].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Female; Hydrox | 2007 |
FR-167653, a selective p38 MAPK inhibitor, exerts salutary effect on liver cirrhosis through downregulation of Runx2.
Topics: Animals; Carbon Tetrachloride; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Dose-Res | 2007 |
Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions.
Topics: Administration, Oral; Alanine; Animals; Atorvastatin; Carbon Tetrachloride; Collagen; Deuterium Oxid | 2007 |
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cicatrix; Liver; Liver Cirrhosis, Experimental; Macrophages; Matrix M | 2007 |
Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Carbon Tetrachloride; Glutathione; G | 2008 |
Quercetin prevents oxidative stress in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Glutathione Peroxidase; Lipid Peroxidation; Liver Cirrhosis | 2007 |
Lymphocyte-hepatic stellate cell proximity suggests a direct interaction.
Topics: Actins; Animals; Carbon Tetrachloride; CD11c Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lym | 2007 |
Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Collagen; Disease Mod | 2007 |
Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: exacerbation by caspase and serine protease inhibition.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Caspase Inhibitors; Cell Survival; Cytochromes | 2007 |
A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspergillus; Carbon Tetrachloride; Colla | 2007 |
Development of an experimental model of induced bacterial peritonitis in cirrhotic rats with or without ascites.
Topics: Animals; Anti-Bacterial Agents; Ascites; Bacterial Infections; Carbon Tetrachloride; Ceftriaxone; Di | 2007 |
Effects and mechanisms of extract from Paeonia lactiflora and Astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Astragalus Plant; Carbon Tetrachloride; | 2007 |
Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver.
Topics: Animals; Carbon Tetrachloride; Contrast Media; Hepatic Artery; Hepatic Veins; Liver; Liver Cirrhosis | 2007 |
Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution.
Topics: Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Cytokines; Glucosylceramides; Killer Cell | 2007 |
[The effects of endothelial progenitor cell transplantation in carbon tetrachloride induced hepatic fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Endothelial Cells; Female; Liver Cirrhosis, Experimental; Rats; Rats, | 2007 |
Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats.
Topics: Adjuvants, Immunologic; Animals; Antioxidants; Carbon Tetrachloride; Dioxoles; Dose-Response Relatio | 2007 |
Functional hepatic recovery after xenotransplantation of cryopreserved fetal liver cells or soluble cell-factor administration in a cirrhotic rat model: are viable cells necessary?
Topics: Animals; Bilirubin; Carbon Tetrachloride; Cell Extracts; Cell Respiration; Cell Survival; Cryopreser | 2008 |
Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Carbon Tetrachloride; Cell Line; Cell Survival; Che | 2007 |
Gene expression profile analysis of the spontaneous reversal of rat hepatic fibrosis by cDNA microarray.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Gene Expression; Gene Expression Profiling; Immun | 2007 |
A novel synthetic oleanolic acid derivative (CPU-II2) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells.
Topics: Actins; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line; Cell Survival; Col | 2008 |
Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Division; Cell Lineage; Cell Separation; C | 2008 |
Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Folic Acid; Gene Expression Regulation; Lipid Peroxidation | 2008 |
[The expression of Na+/H- exchanger mRNA in rat liver fibrotic tissues induced by CCl4].
Topics: Animals; Carbon Tetrachloride; H(+)-K(+)-Exchanging ATPase; Liver; Liver Cirrhosis, Experimental; Ma | 2007 |
Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Ce | 2008 |
[Akt gene therapy for cirrhotic rats with portal hypertension].
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Genetic Therapy; Hypert | 2008 |
Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Communication; Cell Proliferation; Cells, Cultured; Cytokines; H | 2008 |
[The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine].
Topics: Alanine Transaminase; Animals; Becaplermin; Carbon Tetrachloride; Curcumin; Cytokines; Drugs, Chines | 2007 |
[Effect of silencing connective tissue growth factor on rat liver fibrosis and the accumulation of extracellular matrix].
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Extracellular Matrix; Gene Silencing | 2008 |
[Inducing rat liver cirrhosis by adjusting the dosage of CCl4 according to body weight changes].
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Experimental; M | 2008 |
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.
Topics: Animals; Arsenamide; Carbon Tetrachloride; Disease Models, Animal; Female; Genetic Predisposition to | 2008 |
Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Mitochondrial protection by low doses of insulin-like growth factor- I in experimental cirrhosis.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Caspase 3; Electron Transport Chain Com | 2008 |
Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats.
Topics: Adenoviridae; Animals; Bile Ducts; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Ce | 2008 |
Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies.
Topics: Actins; Animals; Anticoagulants; Carbon Tetrachloride; Factor V; Gene Expression; Hydroxyproline; Li | 2008 |
The role of hepatic arterial flow on portal venous and hepatic venous wedged pressure in the isolated perfused CCl4-cirrhotic liver.
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Hepatic Artery; Hepatic Veins; Liver; Liver Cirr | 2008 |
The effect of cirrhosis and ethanol ingestion on hepatic iron deposition in the rat.
Topics: Animals; Carbon Tetrachloride; Choline Deficiency; Ethanol; Iron; Liver; Liver Cirrhosis, Experiment | 1967 |
The utilisation of proline by the sinusoidal cells of mouse liver damaged by hepatotoxic agents.
Topics: Animals; Autoradiography; Benzene; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Mice; Prolin | 1967 |
Experimental hepatocerebral disease. Astrocytic changes in the globus pallidus of rats with carbon tetrachloride induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Globus Pallidus; Liver Cirrhosis, Experimental; Male; N | 1967 |
Morphological and biochemical study of the hepatoprotective effect of AICA-phosphate.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Tetrachloride; Imidazoles; Liver Cirrhosis, Experimental | 1980 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1983 |
Experimental cirrhosis and deposition of glomerular IgA immune complexes.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Glomerular Mesangium; Immunoglobulin A; Liv | 1984 |
A morphometric analysis of the hypertrophy of experimental liver cirrhosis.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Connective Tissue; Hepatomegaly; Hypertroph | 1983 |
Microsomal protein synthesis and induction of cytochrome P-450 in cirrhotic rat liver.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Liver Cirrhosis, Experim | 1984 |
Pulmonary interstitial edema in experimental cirrhosis of the liver in rats.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Lung; Male; Pulmonary Edema; Ra | 1984 |
Standardized micronodular cirrhosis in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Dose-Response Relationship, Drug | 1984 |
Effect of carbon tetrachloride--alcohol-induced liver fibrosis on microsomal mixed-function oxidases and the cytosolic glutathione-conjugating system in rat liver.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytosol; Ethanol; Female; Glutathione | 1983 |
Controlled induction of cirrhosis in the rat.
Topics: Aging; Animals; Ascites; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver; | 1983 |
Fibrogenesis in rat liver injured by carbon tetrachloride. An immunohistochemical study.
Topics: Animals; Carbon Tetrachloride; Collagen; Fatty Liver; Liver; Liver Cirrhosis, Experimental; Rats | 1982 |
High yield micronodular cirrhosis in the rat.
Topics: Animals; Ascites; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver; Liver | 1982 |
Qualitative study on the Kupffer cells in the liver of ethanol- and carbon tetrachloride-treated rats.
Topics: Animals; Ascitic Fluid; Carbon Tetrachloride; Cell Adhesion; Ethanol; Kupffer Cells; Liver Cirrhosis | 1982 |
[Effect of malotilate (diisopropyl 1, 3-dithiol-2-ylidenemalonate) on chronic liver injury caused by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hydroxyproline; Liver; Liver Cirrhosi | 1982 |
Exercise in rats with liver injury induced by carbon tetrachloride or bile duct obstruction. Blood cholic acid and liver histology.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cholic Acids; Glycocholic Acid; Liver Cirrhosis | 1982 |
[Effect of vitamin B 12 on liver regeneration without hepatectomy and before hepatectomy after previous induction of liver cirrhosis by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Female; Hepatectomy; Liver Cirrhosis, Experimental; Liver Regeneratio | 1980 |
A bovine muscle extract with anti-cirrhotic and anti-inflammatory properties in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cattle; Collagen; Female; Inflammation; Liv | 1981 |
Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hepatomegaly; Liver; L | 1981 |
Role of vasopressin in impaired water excretion in conscious rats with experimental cirrhosis.
Topics: Animals; Arginine Vasopressin; Blood Volume; Body Water; Carbon Tetrachloride; Diabetes Insipidus; K | 1981 |
Interstitial collagen polymorphism in rat liver with CCl4-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Cyanogen Bromide; Female; Humans; Liver; Liver Cirrhosis, A | 1980 |
Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats.
Topics: Animals; Aorta; Arginine; Blotting, Northern; Carbon Tetrachloride; Endothelium, Vascular; Enzyme In | 1995 |
Changes in expression of the albumin, fibronectin and type I procollagen genes in CCl4-induced liver fibrosis: effect of pyridoxol L,2-pyrrolidon-5 carboxylate.
Topics: Albumins; Animals; Blotting, Northern; Carbon Tetrachloride; Disease Models, Animal; Drug Combinatio | 1993 |
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
Topics: Acute-Phase Proteins; Animals; Antioxidants; Carbon Tetrachloride; Cytokines; Dexamethasone; Free Ra | 1995 |
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment.
Topics: Animals; Carbon Tetrachloride; Cystathionine; DNA; Folic Acid; Homocysteine; Liver; Liver Cirrhosis, | 1995 |
Alterations of trace elements in kidney, spleen and lungs in treated and untreated experimental liver cirrhosis.
Topics: Allopurinol; Animals; Carbon Tetrachloride; Kidney; Liver Cirrhosis, Experimental; Lung; Male; Rats; | 1995 |
Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver.
Topics: Adipocytes; Animals; Binding Sites; Blotting, Northern; Carbon Tetrachloride; Collagen; Gene Express | 1995 |
Expression of HGF and TGF-beta 1 mRNA after partial hepatectomy in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Hepatectomy; Hepatocyte Growth Factor; Liver Cirrhosis, Experimental; | 1995 |
Significance of aminopyrine breath test as a parameter of hepatic functional reserve in 40% partial hepatectomy of rats with CCl4-induced liver injury.
Topics: Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Breath Tests; Carbon Tetrac | 1995 |
Immunolocalization of heparin-binding growth factors (HBGF) types 1 and 2 in rat liver. Selective hyperexpression of HBGF-2 in carbon tetrachloride-induced fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblast Gr | 1993 |
Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; F | 1995 |
No effect of neutralizing antibody to TGF-beta 1 in acute CC14-induced liver fibrogenesis.
Topics: Acute Disease; Animals; Antibodies; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male | 1994 |
Differential effect of micronodular and biliary cirrhosis on epidermal growth factor receptor expression in the rat.
Topics: Animals; Blotting, Northern; Blotting, Western; Carbon Tetrachloride; ErbB Receptors; Liver; Liver C | 1994 |
Iron overload facilitates hepatic fibrosis in the rat alcohol/low-dose carbon tetrachloride model.
Topics: Animals; Carbon Tetrachloride; Ethanol; Female; Iron; Liver; Liver Cirrhosis, Experimental; Pregnanc | 1995 |
Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats.
Topics: Administration, Inhalation; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Liv | 1995 |
The role of the autonomic nervous system in chemically-induced liver damage and repair--using the essential hypertensive animal model (SHR).
Topics: Alanine Transaminase; Animals; Autonomic Nervous System; Carbon Tetrachloride; Histocytochemistry; H | 1995 |
Role of cirrhosis in the hemodynamic response to hemorrhage in portal hypertension.
Topics: Animals; Carbon Tetrachloride; Common Bile Duct; Hemodynamics; Hemorrhage; Hypertension, Portal; Lig | 1995 |
Influence of chronic liver damage on regeneration of the organ in rats.
Topics: Adenine Nucleotides; Animals; Body Weight; Carbon Tetrachloride; Energy Metabolism; Hepatectomy; Liv | 1995 |
Kupffer cell function in chronic liver injury and after partial hepatectomy.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Hepatectomy; Kupffer Cells; Liver; Liver Cirrhosis, | 1994 |
Bacterial translocation in cirrhotic rats. Its role in the development of spontaneous bacterial peritonitis.
Topics: Animals; Ascitic Fluid; Carbon Tetrachloride; Enterobacteriaceae; Intestines; Leukocyte Count; Liver | 1994 |
Assessment of the carbon tetrachloride-induced cirrhosis model for studies of nitrogen metabolism in chronic liver disease.
Topics: Amino Acids; Animals; Carbon Tetrachloride; Cholesterol; Disease Models, Animal; Fatty Acids, Nonest | 1994 |
Fibrogenic and collagenolytic activity in carbon-tetrachloride-injured rats: beneficial effects of zinc administration.
Topics: Animals; Carbon Tetrachloride; Collagen; Collagenases; Liver; Liver Cirrhosis, Experimental; Male; P | 1994 |
Insulin secretion in pancreatic islets from rats with cirrhosis.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Carbon Tetrachloride; Female; Glucose; Glucose Tolera | 1994 |
Effect of a balanced amino acid-based diet on the nitrogen metabolism in carbon tetrachloride-induced liver injury.
Topics: Amino Acids, Branched-Chain; Animals; Brain; Carbon Tetrachloride; Hepatic Encephalopathy; Liver Cir | 1994 |
Relationship between oxidative hepatic metabolism, urinary sodium excretion and sympathetic nerve activity in experimental cirrhosis in the rat.
Topics: Aminopyrine; Animals; Blood Pressure; Breath Tests; Carbon Tetrachloride; Glomerular Filtration Rate | 1995 |
[Experimental study on changes of the pulmonary vessels in the cirrhotic rats].
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Hemodynamics; Hypertension, Pulmonary; Liver Cir | 1995 |
Changes in distribution and activity of glutamine synthetase in carbon tetrachloride-induced cirrhosis in the rat: potential role in hyperammonemia.
Topics: Ammonia; Animals; Carbon Tetrachloride; Glutamate-Ammonia Ligase; Glutamine; Immunohistochemistry; L | 1994 |
CCL4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Copper; Disease Models, Animal; Estradiol; | 1994 |
Coexpression of the collagen-binding stress protein HSP47 gene and the alpha 1(I) and alpha 1(III) collagen genes in carbon tetrachloride-induced rat liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Desmin; Gene Expression Regulation; Heat-Shock Proteins; HS | 1994 |
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; | 1994 |
Detection of liver fibrosis with magnetic cross-relaxation.
Topics: Animals; Body Water; Carbon Tetrachloride; Hydroxyproline; Image Enhancement; Liver; Liver Cirrhosis | 1994 |
Effects of zinc on hepatic ornithine transcarbamylase (OTC) activity.
Topics: Ammonia; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental | 1993 |
Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats.
Topics: 3-Hydroxybutyric Acid; Adenosine; Animals; Carbon Tetrachloride; Collagen; Hydroxybutyrates; Lactate | 1994 |
Blunted natriuretic response to human urine extracts with Na+,K(+)-ATPase inhibiting activity in experimental cirrhosis.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Female; Hemodynamics; Humans; Liver Cirrhosis, Experi | 1994 |
Dynamics of hepatic collagen synthesis and intracellular degradation of newly synthesized collagen during chronic carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Collagen; Liver; Liver Cirrhosis, Experimental; Male | 1994 |
[Changes in the hemato-encephalic barrier in experimental liver cirrhosis].
Topics: Animals; Blood-Brain Barrier; Brain; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimen | 1993 |
IL-6 induces hepatic inflammation and collagen synthesis in vivo.
Topics: Adipocytes; Animals; Carbon Tetrachloride; Collagen; Hepatitis, Animal; Interleukin-6; Liver Cirrhos | 1994 |
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
Topics: Allantoin; Aluminum Hydroxide; Animals; Antacids; Aspirin; Carbon Tetrachloride; Diethylnitrosamine; | 1994 |
Nifedipine in rat liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Ethanol; Lactates; Lactic Acid; Liver; Liver Cirrhosis, Experimental; | 1994 |
Impaired function of pancreatic islets from rats with portal hypertension resulting from cirrhosis and partial portal vein ligation.
Topics: Animals; Carbon Tetrachloride; Glucagon; Hypertension, Portal; In Vitro Techniques; Insulin; Insulin | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats.
Topics: Animals; Carbon Tetrachloride; Cell Division; Collagen; Female; Fibroblasts; Immunoenzyme Techniques | 1994 |
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition.
Topics: Animals; Antipyrine; Bile Acids and Salts; Breath Tests; Carbon Tetrachloride; Lipids; Liver Cirrhos | 1993 |
Zinc supplementation in experimental liver cirrhosis: a morphological, structural and ultrastructural study.
Topics: Animals; Carbon Tetrachloride; Collagen; Liver; Liver Cirrhosis, Experimental; Male; Microscopy, Ele | 1993 |
Zinc counteracts experimentally-induced cirrhotic changes in rats.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Rats; Zinc | 1993 |
Role of hepatic vitamin A and lipocyte distribution in experimental hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Diterpenes; Hydroxyproline; Liver; Liver Cirrhosis, Experim | 1993 |
Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Hydroxyproline; Liver; Liver Cirrhosis, Experimenta | 1994 |
Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Desmin; Granuloma; Immunoenzy | 1993 |
Increase of hepatic mRNAS of profilin, actin and extracellular matrix proteins after carbon tetrachloride treatment and partial hepatectomy in rats.
Topics: Actins; Animals; Blotting, Northern; Carbon Tetrachloride; Contractile Proteins; Extracellular Matri | 1994 |
Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats.
Topics: Animals; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Cholesterol; Erythrocyte | 1994 |
Localization and mRNA steady-state level of cellular fibronectin in rat liver undergoing a CCl4-induced acute damage or fibrosis.
Topics: Animals; Carbon Tetrachloride; Female; Fibronectins; Liver; Liver Cirrhosis, Experimental; Rats; Rat | 1993 |
Renal effects of atrial natriuretic peptide in cirrhotic rats with and without captopril pretreatment.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Carbon Tetrachloride; Glomerular Filtration Rate; Kid | 1993 |
Hepatic enzyme activity is the major factor determining elimination rate of high-clearance drugs in cirrhosis.
Topics: Animals; Carbon Tetrachloride; Glucuronates; In Vitro Techniques; Kinetics; Liver; Liver Circulation | 1993 |
Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Acetaldehyde; Animals; Animals, Newborn; Body Weight; Carbon Tetrachloride; Diethylnitrosamine; Etha | 1993 |
Mononuclear phagocyte system responsiveness in CCl4-induced liver cirrhosis.
Topics: Animals; Bone Marrow; Carbon Tetrachloride; Kupffer Cells; Liver Cirrhosis, Experimental; Lung; Macr | 1993 |
Sex hormones and trace elements in rat CCL4-induced cirrhosis and hepatocellular carcinoma.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Copper; | 1993 |
The stellate cells phenotypic transformation in the CCl4- injured liver fibrosis of ICR mice: their desmin immunoreactivity and vitamin A storage.
Topics: Animals; Carbon Tetrachloride; Collagen; Desmin; Granuloma; Liver; Liver Cirrhosis, Experimental; Ma | 1993 |
Erythrocyte alterations correlate with CCl4 and biliary obstruction-induced liver damage in the rat.
Topics: Animals; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Cholestasis; Erythrocyte | 1993 |
Augmented portal flow in the isolated perfused cirrhotic rat liver: a haemodynamic and morphological study.
Topics: Animals; Carbon Tetrachloride; Cell Death; Liver; Liver Cirrhosis, Experimental; Male; Perfusion; Po | 1993 |
Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43.
Topics: Animals; Carbon Tetrachloride; Cell Division; Clone Cells; Connexins; Extracellular Matrix Proteins; | 1993 |
Reduced renal papillary plasma flow in non-ascitic cirrhotic rats.
Topics: Animals; Body Fluids; Carbon Tetrachloride; Diuresis; Hemodynamics; Kidney Medulla; Liver Cirrhosis, | 1993 |
Vasopressin gene expression in rats with experimental cirrhosis.
Topics: Animals; Arginine Vasopressin; Carbon Tetrachloride; Gene Expression; Hypothalamus; Liver Cirrhosis, | 1993 |
Colchicine alters lactate utilization in isolated hepatocytes of rats treated with CCl4 and ethanol.
Topics: Alcoholic Intoxication; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Colchicine; E | 1993 |
Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; beta 2-Microglobulin; Carbon Tetrachloride; Collagen; Gene Expression; Genes; Humans; Liver | 1993 |
Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Chlorpromazine; In Vitro Techniques; Liver; Liver Circula | 1993 |
Lipocytes from fibrotic rat liver have an impaired feedback response to procollagen propeptides.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Collagen; Feedback; Female; Ligation; Lipid Metabolism; L | 1993 |
Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis.
Topics: Actin Cytoskeleton; Actins; Animals; Carbon Tetrachloride; Cytoskeleton; Desmin; Disease Models, Ani | 1993 |
Induction of prothrombin biosynthesis and inhibition of gamma carboxylase activity in experimental models of liver regeneration and fibrosis.
Topics: Animals; Carbon Tetrachloride; Carbon-Carbon Ligases; Ligases; Liver; Liver Cirrhosis, Experimental; | 1993 |
Chylomicron metabolism in experimental cirrhosis and cholestasis.
Topics: Animals; Carbon Tetrachloride; Cholestasis; Cholesterol; Chylomicrons; Emulsions; Lipolysis; Liver C | 1993 |
Glutathione in plasma, liver, and kidney in the development of CCl4-induced cirrhosis of the rat.
Topics: Animals; Carbon Tetrachloride; Glutathione; Glutathione Disulfide; Humans; Kidney; Liver; Liver Cirr | 1995 |
Increased capillary endothelial leakage in portal hypertensive gastric mucosa: fluorescence microscopy in CCl4-induced cirrhotic rats.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Membrane Permeability; Endothelium, Vascular; Fluoresc | 1995 |
Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). III. Chronic CCl4-induced liver damage with eventual cirrhosis in rabbits.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Glycine; Imino Acids; Liver; Liver Cirrhosis, Expe | 1995 |
Role of vitamin A in liver fibrosis.
Topics: Animals; Antioxidants; beta Carotene; Carbon Tetrachloride; Carotenoids; Female; Liver Cirrhosis, Ex | 1995 |
Depressed sensitivity of the hepatoportal NaCl receptors in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Diet, Sodium-Restricted; Hypertonic Solutions; Isotonic | 1995 |
Acute-phase response in rat to carbon tetrachloride-azathioprine induced cirrhosis and partial hepatectomy of cirrhotic liver.
Topics: Acute-Phase Reaction; alpha 1-Antitrypsin; Animals; Antimetabolites; Azathioprine; Carbon Tetrachlor | 1996 |
Carbon tetrachloride-induced cirrhosis in rats: influence of the acute effects of the toxin on glucose metabolism.
Topics: Animals; Carbon Tetrachloride; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Insulin; In | 1996 |
Involvement of calcium in macrophage leukotriene release during experimental cirrhosis.
Topics: Analysis of Variance; Animals; Arachidonate 5-Lipoxygenase; Calcimycin; Calcium; Carbon Tetrachlorid | 1996 |
Oral supplementation with branched-chain amino acids improves transthyretin turnover in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Food, | 1996 |
Expression of extracellular matrix proteoglycans perlecan and decorin in carbon-tetrachloride-injured rat liver and in isolated liver cells.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Cells, Cultured; Decorin; Endothelium, Vascular; | 1996 |
Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats.
Topics: Animals; Binding, Competitive; Carbon Tetrachloride; Endothelins; Liver; Liver Cirrhosis, Experiment | 1996 |
Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers.
Topics: Animals; Carbon Tetrachloride; Desmin; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipid | 1996 |
Protein metabolism in cirrhotic rats: effect of dietary restriction.
Topics: Amino Acids; Animals; Body Weight; Carbon Tetrachloride; Food Deprivation; Intestine, Small; Kidney; | 1995 |
[The mechanism for splenic promoting effects on liver cirrhosis].
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Fibronectins; Laminin; Liver Cirrhosis, Ex | 1995 |
UDP glucuronosyltransferase in the cirrhotic rat liver.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Glucuronosyltransferase; Immunoblotting; Immunohi | 1996 |
[A quantitative study on alpha-1 adrenergic receptor in the liver of Wistar rats during the process of CCl4-induced hepatic cirrhosis].
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Radioligand Assay; Rats; | 1995 |
Paracrine renal endothelin system in rats with liver cirrhosis.
Topics: Animals; Bosentan; Carbon Tetrachloride; Endothelin Receptor Antagonists; Endothelins; Glomerular Fi | 1996 |
[99mTc-MIBI used for diagnosis of portal hypertension: an experimental study].
Topics: Administration, Rectal; Animals; Carbon Tetrachloride; Heart; Hypertension, Portal; Injections, Intr | 1995 |
Glial fibrillary acidic protein--a cell type specific marker for Ito cells in vivo and in vitro.
Topics: Animals; Biomarkers; Blotting, Northern; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; F | 1996 |
Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats.
Topics: Animals; Aorta; Ascites; Carbon Tetrachloride; Cyclic GMP; Hemodynamics; Hypertension, Portal; Ligat | 1996 |
A potential experimental model for the study of osteopenia in CCl4 liver cirrhotic rats.
Topics: Animals; Body Weight; Bone Diseases, Metabolic; Carbon Tetrachloride; Densitometry; Disease Models, | 1996 |
Histopathological sequence of hepatic and renal lesions in rats after cessation of the repeated administration of CCl4.
Topics: Animals; Carbon Tetrachloride; Drug Administration Schedule; Glomerulonephritis; Kidney; Liver; Live | 1995 |
Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat.
Topics: Animals; Apolipoproteins; Apolipoproteins A; Carbon Tetrachloride; Immunohistochemistry; Intestinal | 1996 |
Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Glutathione; Lipid Peroxides; Liver; Liver Cirrhosis, Exper | 1996 |
The effect of nicotine and its interaction with carbon tetrachloride in the rat liver.
Topics: Animals; Carbon Tetrachloride; Drug Interactions; Drug Synergism; Female; Injections, Subcutaneous; | 1995 |
Formylcolchicine bound to lactosaminated serum albumin is a more active antifibrotic agent than free colchicine.
Topics: Amino Sugars; Animals; Carbon Tetrachloride; Colchicine; Liver Cirrhosis, Experimental; Male; Protei | 1996 |
[Stimulation of regenerative processes and correction of the functional activity of the liver in its partial resection and toxic lesions].
Topics: Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; G | 1996 |
Enhancement of proliferation of intrasplenically transplanted hepatocytes in cirrhotic rats by hepatic stimulatory substance.
Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Cell Division; Cell Transplantation; Growth Substa | 1997 |
Liver metabolic zonation and hepatic microcirculation in carbon tetrachloride-induced experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Histocytochemistry; Liver; Liver Cirrhosis, Experimental; Male; Micro | 1997 |
Bone changes and mineral metabolism disorders in rats with experimental liver cirrhosis.
Topics: Animals; Bone and Bones; Calcium; Carbon Tetrachloride; Intestine, Small; Liver; Liver Cirrhosis, Ex | 1996 |
Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats.
Topics: Animals; Calcium-Transporting ATPases; Carbon Tetrachloride; Cholesterol; Colchicine; Erythrocyte Me | 1997 |
The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver.
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Disease Models, Animal; Female; Histamine; Hypertension | 1997 |
Effects of long-term administration of octreotide on sodium retention and atrial natriuretic peptide in carbon tetrachloride-induced cirrhotic rats.
Topics: Animals; Atrial Natriuretic Factor; Carbon Tetrachloride; Heart Atria; Hemodynamics; Hormones; Liver | 1997 |
[Inhibitory effect of tetrandrine on collagen synthesis of experimental hepatic fibrosis in rats].
Topics: Alkaloids; Animals; Benzylisoquinolines; Carbon Tetrachloride; Collagen; Liver; Liver Cirrhosis, Exp | 1996 |
Heterogeneity of liver cells expressing procollagen types I and IV in vivo.
Topics: Adult; Animals; Carbon Tetrachloride; Desmin; Endothelium; Epithelial Cells; Epithelium; Extracellul | 1997 |
Lymph vessel expansion and function in the development of hepatic fibrosis and cirrhosis.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Kinetics; Liver; Liver Cirrhosis, Experimental; Lymphatic S | 1997 |
Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Dimet | 1997 |
Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites.
Topics: Animals; Ascites; Benzylidene Compounds; Carbon Tetrachloride; Enzyme Inhibitors; Hypertension, Port | 1997 |
gamma-Interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis.
Topics: Animals; Bicarbonates; Bile; Bile Ducts; Carbon Tetrachloride; Cell Division; Collagen; Interferon-g | 1997 |
Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hepatocyte Gro | 1997 |
Accelerated development of liver fibrosis in CCl4-treated rats by the weekly induction of acute phase response episodes: upregulation of alpha1(I) procollagen and tissue inhibitor of metalloproteinase-1 mRNAs.
Topics: Acute-Phase Reaction; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Pro | 1997 |
Up-regulation of type I procollagen C-proteinase enhancer protein messenger RNA in rats with CCl4-induced liver fibrosis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Protein 1; Bone Morphogenetic Protei | 1997 |
Impaired intestinal sugar transport in cirrhotic rats: correction by low doses of insulin-like growth factor I.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Blood Proteins | 1997 |
Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels.
Topics: Amino Acids; Ammonia; Animals; Carbon Tetrachloride; Dipeptides; Liver; Liver Cirrhosis, Experimenta | 1997 |
Cytoprotective activity in the gastric mucosa of rats exposed to carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Disease Models, Animal; Drug Resistance; Ethanol; Gastr | 1997 |
Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Catalase; Collagen; Insulin-Like Growth Factor I; Lipid Peroxidation; | 1997 |
Balance between oxidative damage and proliferative potential in an experimental rat model of CCl4-induced cirrhosis: protective role of adenosine administration.
Topics: Adenosine; Alkadienes; Animals; Carbon Tetrachloride; Cell Division; DNA; Enzymes; Glutathione; Live | 1997 |
Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Cell Culture Techniques; Fibroblasts; Fibronectin | 1997 |
Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Liver; Liver Cirrhosis, Experimental; Male; Pyridin | 1998 |
Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension.
Topics: Animals; Carbon Tetrachloride; Endothelium; Hypertension, Portal; Kupffer Cells; Ligation; Liver; Li | 1998 |
Diagnostic value of a superparamagnetic iron oxide in MR imaging of chronic liver disease in an animal model.
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Contrast Media; Ferric Compounds; Liver; Liver Cirrh | 1998 |
An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Hyper | 1998 |
Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Hepatocyte Growth Factor; Humans; Hyaluronic Aci | 1998 |
Induction of heat shock response: effect on the rat liver with carbon tetrachloride-induced fibrosis from ischemia-reperfusion injury.
Topics: Animals; Carbon Tetrachloride; Heat-Shock Proteins; Hot Temperature; HSP72 Heat-Shock Proteins; Isch | 1998 |
Spatial and temporal dynamics of hepatic stellate cell activation during oxidant-stress-induced fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Collagen; Free Radicals; Heme Oxygenase (Decyclizing); Immunohistoche | 1998 |
Glycogen-forming function of hepatocytes in the rat regenerating cirrhotic liver after a partial hepatectomy.
Topics: Animals; Biopsy; Carbon Tetrachloride; Glucose-6-Phosphatase; Glycogen; Glycogen Synthase; Hepatecto | 1998 |
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagenases; Gene | 1998 |
Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chick Embryo; Collagen; Enzyme Inhibitors; Female; G | 1998 |
Mast cell, myofibroblast and nerve terminal complexes in carbon tetrachloride-induced cirrhotic rat livers.
Topics: Actins; Animals; Carbon Tetrachloride; Cholinergic Fibers; Chymases; Extracellular Matrix; Fibroblas | 1998 |
Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4- plus ethanol-induced liver cirrhosis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Ethanol; Glycyrrhizic Acid; | 1998 |
Intrahepatic flow disturbance as detected by in vivo acridine orange staining in endothelin-1-treated and cirrhotic rats.
Topics: Acridine Orange; Animals; Carbon Tetrachloride; Endothelin-1; Femoral Vein; Liver; Liver Circulation | 1998 |
Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cytokines; Female; Hepatitis, Animal; Interleukin-10 | 1998 |
Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Movement; Chemical and Drug Induced Liver Injury; | 1998 |
Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal; Extracellular Matrix Proteins; Free Radical Sc | 1998 |
The protective effects of traditional Chinese medicine prescription, han-dan-gan-le, on CCl4-induced liver fibrosis in rats.
Topics: Animals; Astragalus propinquus; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Injections, S | 1998 |
Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing.
Topics: Animals; Aspartic Acid Endopeptidases; Carbon Tetrachloride; Cells, Cultured; Endothelin-1; Endothel | 1999 |
Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells.
Topics: Actins; Animals; Base Sequence; Carbon Tetrachloride; Cells, Cultured; Desmin; Glial Fibrillary Acid | 1999 |
Adenovirus-mediated gene expression in the septal cells of cirrhotic rat livers.
Topics: Adenoviridae; Adenoviridae Infections; Animals; Carbon Tetrachloride; Gene Expression; Gene Transfer | 1999 |
Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration.
Topics: Animals; Body Weight; Carbon Tetrachloride; Cell Division; DNA; Hepatectomy; Kinetics; Liver; Liver | 1999 |
Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis.
Topics: Animals; Base Sequence; Blotting, Northern; Carbon Tetrachloride; Dose-Response Relationship, Drug; | 1999 |
Changes of sinusoidal basement membrane collagens in early hepatic fibrosis induced with CCl4 in cynomolgus monkeys.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Basement Membrane; | 1999 |
Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites.
Topics: Animals; Ascites; Body Water; Carbon Tetrachloride; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygena | 1999 |
Evaluation of different models of experimentally induced liver cirrhosis for MRI research with correlation to histopathologic findings.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Chronic Disease; Follow-Up Studies; Liver; Liver Cirrhos | 1999 |
Differential effect of CCl4 on renal function in cirrhotic and non-cirrhotic rats.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Hemodynamics; Kidney; Kidney Function Tests; Liver; Li | 1999 |
Endothelin-induced contraction of the portal vein in cirrhosis.
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-3; Hyperte | 1999 |
Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice.
Topics: Animals; Bile Ducts; Blood; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver; Liver Cirrhosis, | 1999 |
[Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Ethanol; Glycyrrhizic Acid; Liver Cirrhosis, Ex | 1999 |
Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone.
Topics: Ammonia; Animals; Anti-Ulcer Agents; Carbon Tetrachloride; Disease Models, Animal; Diterpenes; Gastr | 1999 |
Exacerbation of acute pancreatitis in the presence of chronic liver injury in rats, with special reference to therapeutic efficacy of prostaglandin E1.
Topics: Acute Disease; alpha-Macroglobulins; Alprostadil; Amylases; Animals; Biomarkers; Carbon Tetrachlorid | 1999 |
Experimental cirrhosis of the liver and cytoprotective effects of alpha tocopherol.
Topics: Analysis of Variance; Animals; Antioxidants; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimen | 1999 |
Microvascular consequences of Kupffer cell modulation in rat liver fibrogenesis.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Gadolinium; Immunohis | 1999 |
Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats.
Topics: Animals; Carbon Tetrachloride; DNA Fragmentation; Hydroxyproline; Liver; Liver Cirrhosis, Experiment | 1999 |
Functional capacity of the cirrhotic liver after partial hepatectomy in the rat.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Hepatectomy; Liver Cirrhosis, Experimental; L | 1999 |
[Change in morphometric parameters in silver-stained nucleoli from hepatocytes of rats with liver cirrhosis and during rehabilitation from it].
Topics: Animals; Carbon Tetrachloride; Cell Nucleolus; Liver Cirrhosis, Experimental; Male; Nucleolus Organi | 1999 |
Hepatic production of apolar aldehydes in rats with carbon tetrachloride-induced cirrhosis.
Topics: Aldehydes; Animals; Antioxidants; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; | 1999 |
Expression of connective tissue growth factor in experimental rat and human liver fibrosis.
Topics: Adolescent; Adult; Animals; Bile Ducts; Carbon Tetrachloride; Cell Line, Transformed; Connective Tis | 1999 |
Expression of inositol 1,4,5-trisphosphate receptor isoforms in rat cirrhosis.
Topics: Animals; Bile Ducts; Calcium Channels; Carbon Tetrachloride; Immunohistochemistry; Inositol 1,4,5-Tr | 1999 |
Changes in growth factor and cytokine mRNA levels after hepatectomy in rat with CCl(4)-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cytokines; Growth Substances; Hepatectomy; Liver; Liver C | 1999 |
31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbon Tetrachloride; Carbon Tetrachloride P | 1999 |
Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice.
Topics: Animals; Carbon Tetrachloride; Female; Gene Expression; Hepatocyte Growth Factor; Interleukin-6; Liv | 1999 |
Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Collagen; Extracellular Matrix; Immun | 1999 |
Two assays for measuring fibrosis: reverse transcriptase-polymerase chain reaction of collagen alpha(1) (III) mRNA is an early predictor of subsequent collagen deposition while a novel serum N-terminal procollagen (III) propeptide assay reflects manifest
Topics: Animals; Base Sequence; Carbon Tetrachloride; Collagen; DNA Primers; Female; Fibronectins; Liver Cir | 1999 |
[Taurine inhibits deposition of extracellular matrix in experimental liver fibrosis in rats].
Topics: Animals; Carbon Tetrachloride; Extracellular Matrix Proteins; Liver Cirrhosis, Experimental; Rats; R | 1999 |
Tryptophan-niacin metabolism in liver cirrhosis rat caused by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Liver Cirrhosis, E | 1999 |
Expression of TNF-alpha and immunohistochemical distribution of hepatic macrophage surface markers in carbon tetrachloride-induced chronic liver injury in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Membrane; Immunoenzyme Techniques; Liver; Liver Cirr | 1999 |
Impaired pancreatic exocrine function in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Amylases; Animals; Carbon Tetrachloride; Cholecystokinin; Humans; In Vitro Techniques; Liver Cirrhos | 1999 |
Insulin secretion defects in liver cirrhosis can be reversed by glucagon-like peptide-1.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Culture Techniques; Dose-Response Relationship, | 2000 |
Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites.
Topics: Animals; Bacteria; Bacterial Translocation; Carbon Tetrachloride; Intestinal Absorption; Intestines; | 2000 |
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DNA-B | 2000 |
Restoration of the glycogen-forming function of hepatocytes in rats with liver cirrhosis is facilitated by a high-carbohydrate diet.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Dietary Carbohydrates; Flow Cytometry; Glucose-6-Pho | 1999 |
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Topics: Adenoviridae; Animals; Apoptosis; Carbon Tetrachloride; Gene Transfer Techniques; Genetic Therapy; G | 2000 |
Hepatocyte transplantation in rats with decompensated cirrhosis.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Transplantation; Graft Survival; Li | 2000 |
Splanchnic endotoxin levels in cirrhotic rats induced by carbon tetrachloride.
Topics: Animals; Ascites; Carbon Tetrachloride; Endotoxins; Hemodynamics; Liver Cirrhosis, Experimental; Mal | 2000 |
Hepatic regeneration and TGF-beta: growing to a prosperous perfection.
Topics: Animals; Carbon Tetrachloride; Cell Division; Gene Expression; Humans; Liver; Liver Cirrhosis, Exper | 2000 |
Transplanted hepatocytes engraft, survive, and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Survival; Cell Transplantation; Graft Survival; H | 2000 |
Increased natriuretic efficiency of furosemide in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Diuresis; Diuretics; Female; Furosemide; Hemodynamics; Kidney Tubules | 2000 |
Expression of the integrin alpha8beta1 during pulmonary and hepatic fibrosis.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Integrins; Ligation; Liver Cirrhosis, Experimental; Pulmo | 2000 |
Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Oxidation-Reduction; Prot | 1999 |
Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis.
Topics: Animals; Aquaporin 1; Aquaporin 2; Aquaporin 3; Aquaporin 6; Aquaporins; Carbon Tetrachloride; Carri | 2000 |
Impact of intrinsic blood flow regulation in cirrhosis: maintenance of hepatic arterial buffer response.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Female; Hepatic Artery; Homeostasis; Liver; Liver Cir | 2000 |
Plasma prolidase may be an index of liver fibrosis in the rat.
Topics: Animals; Carbon Tetrachloride; Dipeptidases; Liver Cirrhosis, Experimental; Rats | 2000 |
Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Benzoates; Carbon Tetrachloride; Cells, Cultured; Liver Cirrhosis, Experimental; Male; Mito | 2000 |
Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Collagenases; Gene Expression Regulation, Enzymologic; Liver Cirrhosi | 2000 |
Time-course of changes in hepatic lipid peroxidation and glutathione metabolism in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Inactiv | 2000 |
Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Anim | 2000 |
Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrhosis.
Topics: Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; Densitometry; | 2000 |
Effect of branched-chain amino acids on the composition and cytolytic activity of liver-associated lymphocytes in rats.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Flow Cytometry; Glutathione Transferase; | 2000 |
[Effect of "vilon" on cirrhotically changed rat liver. Liver regeneration, and status of glycogen-forming function of hepatocytes].
Topics: Animals; Carbon Tetrachloride; Dipeptides; Glucose-6-Phosphatase; Glycogen Synthase; Hepatocytes; Li | 2000 |
Hepatic microvascular features in experimental cirrhosis: a structural and morphometrical study in CCl4-treated rats.
Topics: Animals; Carbon Tetrachloride; Connective Tissue; Image Processing, Computer-Assisted; Liver; Liver | 2000 |
Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Isoenzymes; Liver; Liver Cirrhosis, B | 2000 |
The role of hepatocyte transplantation to treat chronic liver failure.
Topics: Ammonia; Animals; Bilirubin; Carbon Tetrachloride; Cell Transplantation; Chronic Disease; Hepatocyte | 2000 |
Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy.
Topics: Animals; Base Sequence; Carbon Tetrachloride; DNA Primers; Enzyme-Linked Immunosorbent Assay; Geneti | 2000 |
Suppression of hemopoiesis during CCl(4)-induced hepatic fibrosis: role of systemic endotoxemia.
Topics: Animals; Carbon Tetrachloride; Colony-Forming Units Assay; Endotoxemia; Hematopoiesis; Liver Cirrhos | 2000 |
Effect of fetal tissue transplantation on reparative processes in experimental liver cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Fetal T | 2000 |
Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-Asso | 2000 |
Enhanced expression of endothelin receptor subtypes in cirrhotic rat liver.
Topics: Animals; Carbon Tetrachloride; Endothelium, Vascular; Gold; Immunoenzyme Techniques; Kupffer Cells; | 2001 |
Hepatic paraoxonase activity alterations and free radical production in rats with experimental cirrhosis.
Topics: Alanine Transaminase; Animals; Aryldialkylphosphatase; Carbon Tetrachloride; Dietary Supplements; En | 2001 |
The antioxidant and hepatoprotective effects of zinc are related to hepatic cytochrome P450 depression and metallothionein induction in rats with experimental cirrhosis.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Catalase; Cytochrome P-450 Enzyme System; Enzym | 2001 |
Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats.
Topics: Adenosine; Animals; Carbon Tetrachloride; Cell Division; Collagen; DNA; Fibronectins; Hepatocytes; H | 2001 |
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
Topics: Acetylcysteine; Amino Acid Motifs; Animals; Apoptosis; Carbon Tetrachloride; Caspase Inhibitors; Cas | 2001 |
Gene-CYP11B2 expression in rat liver in hepatic fibrogenesis induced by CCl4.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP11B2; Gene Expression Regulation, Enzymologic; In | 2001 |
Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I.
Topics: Animals; Carbon Tetrachloride; CCAAT-Binding Factor; DNA Methylation; DNA-Binding Proteins; Gene Exp | 2002 |
[Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites].
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Guanid | 2001 |
Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats.
Topics: Administration, Inhalation; Animals; Carbon Tetrachloride; Cholinesterase Inhibitors; Growth Hormone | 2001 |
Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice.
Topics: Animals; Ascites; Carbon Tetrachloride; Chlorides; Drugs, Chinese Herbal; Liver; Liver Cirrhosis, Ex | 2002 |
Effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Digestive System; Enzyme Inhibitors; Gastrointestinal Motility; Human | 2002 |
[Expression of activins, follistatin mRNA in the development of hepatic fibrosis].
Topics: Activins; Animals; Carbon Tetrachloride; Follistatin; Gene Expression; Inhibin-beta Subunits; Liver | 2002 |
[Expression of integrin alpha 6 in hepatic sinusoidal capillaration].
Topics: Animals; Antigens, CD; Carbon Tetrachloride; Immunoblotting; Immunohistochemistry; Integrin alpha6; | 2002 |
[Relationship between plasma carbon monoxide and blood-brain barrier permeability in cirrhotic rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Pressure; Blood-Brain Barrier; Cap | 2002 |
[Amelioration of carbon tetrachloride-induced hepatic fibrosis in rats by treatment with salvia miltiorrhiza and taurine].
Topics: Alanine Transaminase; Albumins; Animals; Bilirubin; Carbon Tetrachloride; Female; Liver; Liver Cirrh | 2002 |
Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Carbo | 2002 |
Tropoelastin expression is up-regulated during activation of hepatic stellate cells and in the livers of CCl(4)-cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Electrophoresis, Aga | 2002 |
[Change in the mitotic activity of hepatocytes and resorption of necrotic areas in the formation of liver cirrhosis].
Topics: Animals; Carbon Tetrachloride; Iodized Oil; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Mi | 1976 |
Collagenase in experimental carbon tetrachloride cirrhosis of the liver.
Topics: Animals; Carbon Tetrachloride; Connective Tissue; Female; Liver; Liver Cirrhosis, Experimental; Micr | 1978 |
Collagen synthesis in explant cultures of normal and CCl4-treated mouse liver.
Topics: Animals; Carbon Tetrachloride; Collagen; Culture Techniques; Liver Cirrhosis, Experimental; Mice; Pr | 1979 |
Cirrhosis and the synthesis of proline and glycine in rat liver.
Topics: Animals; Carbon Tetrachloride; Collagen; Drug Interactions; Glycine; Liver; Liver Cirrhosis, Experim | 1979 |
Effects of essential fatty acid deficiency and carbon tetrachloride-induced liver cirrhosis on lipid and fatty acid compositions of oral palatal epithelium in rats.
Topics: Animals; Carbon Tetrachloride; Diet; Epithelium; Fatty Acids; Fatty Acids, Essential; Fatty Acids, U | 1976 |
A micropuncture study of salt and water retention in chronic experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Inulin; Kidney; Liver Cirrhosis | 1977 |
Actin-like contractile protein in carbon tetrachloride-induced cirrhosis in the rat.
Topics: Actins; Animals; Antibodies; Antigens; Carbon Tetrachloride; Contractile Proteins; Liver; Liver Cirr | 1977 |
Histochemical studies on the liver of Heteropneustes fossilis treated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Count; Cell Nucleus; DNA; Fishes; Liver; Liver Cirrhosis, Experi | 1976 |
Intrahepatic microvascular changes in carbon tetrachloride-induced cirrhotic livers in the rat.
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Erythrocytes; Hepatic Veins; Liver; Liver Circul | 1976 |
[D-penicillamine slowing down the spontaneous regression of carbon tetrachloride cirrhosis].
Topics: Animals; Carbon Tetrachloride; Collagen; Liver; Liver Cirrhosis, Experimental; Male; Penicillamine; | 1976 |
Malotilate completely inhibits CCl4-induced liver cirrhosis in rats: biochemical and morphological analysis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Lipids; Liver; Liver Cirrhosis, Experimental; Male; Malo | 1992 |
Zinc status in liver and gastrointestinal diseases.
Topics: Adult; Animals; Carbon Tetrachloride; Carrier Proteins; Chronic Disease; Copper; Gastrointestinal Di | 1992 |
Hepatocyte membrane stabilization by prostaglandins E1 and E2: favorable effects on rat liver injury.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Bucladesine; Carbon Tetrachloride; Cell Membra | 1992 |
Characterization of membrane fraction lipid composition and function of cirrhotic rat liver. Role of S-adenosyl-L-methionine.
Topics: Adenosine Triphosphatases; Animals; Calcium-Transporting ATPases; Carbon Tetrachloride; Cation Trans | 1992 |
Pressor response to a postural change in cirrhosis: an experimental study in the CCl4-treated rat.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Hemodynamics; Liver; Liver Cirrhosis, Experimental; N | 1992 |
Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbon Tetrachloride; Cholesterol | 1992 |
Arachidonate metabolism in D-galactosamine or carbon tetrachloride-induced acute and chronic liver injuries in rats.
Topics: Acute Disease; Animals; Arachidonic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1992 |
[Effects of spleen on inducing portal hypertension and liver cirrhosis in rats].
Topics: Animals; Carbon Tetrachloride; Ethanol; Hypertension, Portal; Liver Cirrhosis, Experimental; Male; R | 1992 |
Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration.
Topics: Animals; Carbon Tetrachloride; Collagen; Collagenases; Lipid Peroxidation; Liver; Liver Cirrhosis, E | 1992 |
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administrati | 1992 |
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu | 1992 |
Cirrhosis impairs serum bacteriostasis for Escherichia coli.
Topics: Animals; Apoproteins; Blood Bactericidal Activity; Carbon Tetrachloride; Escherichia coli; Iron; Liv | 1992 |
Splanchnic haemodynamic effects of ketanserin in anaesthetized cirrhotic rats.
Topics: Animals; Atenolol; Bile Acids and Salts; Blood Pressure; Carbon Tetrachloride; Chenodeoxycholic Acid | 1992 |
[Functional state of the hematopoietic system in different stages of CCL4-induced liver fibrosis in mice].
Topics: Animals; Carbon Tetrachloride; Colony-Forming Units Assay; Erythropoiesis; Hematopoiesis; Liver Cirr | 1992 |
Gastric mucosal blood flow distribution in the CCl4-induced cirrhotic rat--a model of portal hypertensive gastropathy?
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Disease Models, Animal; Gastric Mucosa; Hyperten | 1992 |
[Pathomorphology of acute and chronic stages of CCl4-induced liver fibrosis: immunohistochemical and in situ hybridization studies].
Topics: Animals; Carbon Tetrachloride; Extracellular Matrix Proteins; Humans; Immunoenzyme Techniques; In Si | 1992 |
Monitoring of serum markers for fibrosis during CCl4-induced liver damage. Effects of anti-fibrotic agents.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Biomarkers; Body Weight; Carbon Tetrachloride; Colchicine; | 1992 |
Zinc supplementation reduces blood ammonia and increases liver ornithine transcarbamylase activity in experimental cirrhosis.
Topics: Administration, Oral; Ammonia; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; | 1992 |
The effect of alcohol-induced hepatomegaly on portal hypertension in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Collagen; Ethanol; Hemodynamics; Hepatomegaly; Hypert | 1992 |
Collagenolytic cathepsin B and L activity in experimental fibrotic liver and human liver.
Topics: Animals; Carbon Tetrachloride; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Collagen; Cysteine | 1992 |
Transforming growth factor-alpha (TGF-alpha) improves hepatic DNA synthesis after hepatectomy in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; DNA; Hepatectomy; Liver; Liver Cirrhosis, Experimental; Liver Regener | 1992 |
Liver plasma membrane-associated fibroblast growth: stimulatory and inhibitory activities during experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Membrane; Connective Tissue; Edetic Acid; Fibrobl | 1992 |
The effects of hepatic fibrosis on Ito cell gene expression.
Topics: Animals; Carbon Tetrachloride; Endothelium; Extracellular Matrix Proteins; Gene Expression Regulatio | 1992 |
Liver cirrhosis induced by carbon tetrachloride and the effect of superoxide dismutase and xanthine oxidase inhibitor treatment.
Topics: Allopurinol; Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosis, Ex | 1992 |
The pituitary in cirrhosis: ultrastructure, growth hormone, and prolactin concentrations.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Golgi Apparatus; Growth Hormone; Immunohistochemistry; | 1992 |
Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture.
Topics: Actins; Adipose Tissue; Animals; Carbon Tetrachloride; Cell Division; Cell Separation; Common Bile D | 1992 |
Abnormal lipid composition of microsomes from cirrhotic rat liver--does it contribute to decreased microsomal function?
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cholesterol; Endoplasmic Reticulum; Fatty Acids; Fluoresc | 1992 |
Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Desmin; Endotheli | 1991 |
The role of capillarization in hepatic failure: studies in carbon tetrachloride-induced cirrhosis.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Capillaries; Carbon Tetrachloride; Female; Ferriti | 1991 |
[A study on changes of liver and salivary glands in rats with experimentally induced liver injuries. Pathological and biochemical observations].
Topics: Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Immunohi | 1990 |
Mechanism of insulin resistance in CCl4-induced cirrhosis of rats.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Deoxyglucose; Epididymis; Glucose; Glucose Clamp Tech | 1992 |
[Hepatocytes from the liver of mice with experimental post-toxic cirrhosis stimulate in heterokaryons DNA synthesis in the nuclei of resting fibroblasts of the NIH 373 line].
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Nucleus; Cells, Cultured; Culture Media; DNA; Fem | 1991 |
Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Line; Collagen; Fibronectins; Interleukin-6; Liv | 1991 |
Regenerative ability of hepatocytes is inhibited in early stages of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; DNA; Female; Kinetics; Liver Cirrhosis, Experimental; Liver Regenerat | 1991 |
Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Benzazepines; Carbon Tetrachloride; Chronic Disease; Hydroxyproline; | 1991 |
In micronodular cirrhosis, hepatocytes retain a normal C-25 hydroxylation capacity toward vitamin D3: a study using the rat carbon tetrachloride-induced cirrhotic model.
Topics: Animals; Calcifediol; Carbon Tetrachloride; Cholecalciferol; Cytochrome P-450 Enzyme System; Hydroxy | 1991 |
Minor contribution of hepatocytes to collagen production in normal and early fibrotic rat livers.
Topics: Amino Acids; Animals; Carbon Tetrachloride; Collagen; Dimethylnitrosamine; Hydroxyproline; Liver; Li | 1991 |
Mucosal lesions of the stomach in liver cirrhosis with a special reference to phospholipid metabolism.
Topics: Animals; Bile Reflux; Carbon Tetrachloride; Disease Models, Animal; Gastric Mucosa; Liver Cirrhosis, | 1991 |
[Dynamic changes of Ito cells in experimental cirrhosis of rat].
Topics: Animals; Carbon Tetrachloride; Desmin; Fibronectins; Kupffer Cells; Liver; Liver Cirrhosis, Experime | 1991 |
The production of hepatic cirrhosis in rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Hyperplasia; Hypertrophy; Liver; Liver Cirrhos | 1991 |
Liver cirrhosis in rats: regeneration and assessment of the role of phenobarbital.
Topics: Animals; Carbon Tetrachloride; Hepatectomy; Liver; Liver Cirrhosis, Experimental; Liver Regeneration | 1991 |
Doses of endothelin have natriuretic effects in conscious rats with cirrhosis and ascites.
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Endothelins; Liver Cirrhosis, Experimental; | 1991 |
The hepatic microcirculation in experimental cirrhosis. A scanning electron microscopy study of microcorrosion casts.
Topics: Animals; Carbon Tetrachloride; Corrosion Casting; Disease Models, Animal; Liver; Liver Cirrhosis, Ex | 1991 |
Decreased hepatic glycogen content and accelerated response to starvation in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Carnitine; Energy Metabolism; Glycogen; Glycogen Synthase; Homeostasi | 1991 |
Ultrastructural localization of type IV collagen and laminin in the Disse space of rat liver with carbon tetrachloride induced fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Immunoenzyme Techniques; Laminin; Liver; Liver Cirrhosis, E | 1991 |
Collagenase of hepatocytes and sinusoidal liver cells in the reversibility of experimental cirrhosis of the liver.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; In Vitro Techniques; Liver; Liver Cirrhosis, Experi | 1990 |
Pneumococcal pneumonia in a rat model of cirrhosis: effects of cirrhosis on pulmonary defense mechanisms against Streptococcus pneumoniae.
Topics: Animals; Antigens, Bacterial; Carbon Tetrachloride; Complement System Proteins; Disease Models, Anim | 1991 |
A rodent model of cirrhosis, ascites, and bacterial peritonitis.
Topics: Animals; Ascites; Bacterial Infections; Carbon Tetrachloride; Disease Models, Animal; Liver Cirrhosi | 1991 |
Temporal relationship between the decrease in arterial pressure and sodium retention in conscious spontaneously hypertensive rats with carbon tetrachloride-induced cirrhosis.
Topics: Aldosterone; Animals; Blood Pressure; Carbon Tetrachloride; Creatinine; Hypertension; Liver Cirrhosi | 1991 |
CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Galactose; Liver; Liver Cirrhosis, Experimental; Male; Ph | 1991 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1991 |
Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "low-dose" carbon tetrachloride vapor in the rat.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, | 1991 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; O | 1991 |
Impaired hepatic handling and processing of lysophosphatidylcholine in rats with liver cirrhosis.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Carbon Radioisotopes; Carbon Tetrachloride; | 1991 |
Systemic and splanchnic hemodynamic effects of molsidomine in rats with carbon tetrachloride-induced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Hemodynamics; Liver Cirrhosis, Experimental; Male; Molsidomine; Rats; | 1991 |
[A study on erythrocyte-membrane osmotic resistance and periodontal changes in rats treated with carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Epithelial Attachment; Erythrocyte Membrane; Gingiva; Hemolysis; Live | 1990 |
Atrial natriuretic peptide, arginine vasopressin, aldosterone and plasma renin activity in carbon tetrachloride-induced cirrhosis in rats.
Topics: Aldosterone; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Carbon Tetrachloride; Liver; | 1990 |
Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Hydroxyp | 1990 |
Depressed function of Kupffer cells in rats with CCl4-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Endocytosis; Endotoxins; Kupffer Cells; Liver Cirrhosis, Experimental | 1990 |
Propranolol metabolism by isolated hepatocytes from normal and cirrhotic rat livers: the effect of albumin.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Survival; Liver; Liver Cirrhosis, Experimental; Male; | 1990 |
Two rat models of hepatic fibrosis. A morphologic and molecular comparison.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Collagen; Disease Models, Animal; Gene Expr | 1990 |
Assessment of hepatic indicators of subchronic carbon tetrachloride injury and recovery in rats.
Topics: Animals; Biological Transport, Active; Body Weight; Carbon Tetrachloride; Deoxyglucose; Dose-Respons | 1990 |
Regulation of TGF beta gene expression in rat liver intoxicated with carbon tetrachloride.
Topics: Actins; Animals; Carbon Tetrachloride; DNA Probes; Gene Expression Regulation; Liver; Liver Cirrhosi | 1990 |
Methylcellulose prevents the regression of carbon tetrachloride-induced liver fibrosis and cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; | 1990 |
Defect of sinusoidal Fc receptors and immune complex uptake in CCl4-induced liver cirrhosis in rats.
Topics: Animals; Antigen-Antibody Complex; Carbon Tetrachloride; Fibronectins; Lectins; Liver; Liver Cirrhos | 1990 |
Participation of hepatocytes on laminin gene expression during CCl4-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Gene Expression Regulation; Laminin; Liver; Liver Cirrhosis, Experime | 1990 |
The onset of sodium retention in experimental cirrhosis in rats is related to a critical threshold of liver function.
Topics: Aminopyrine; Animal Feed; Animals; Breath Tests; Carbon Tetrachloride; Creatine; Differential Thresh | 1990 |
Is macronodular liver cirrhosis an irreversible lesion? Changes in the intrahepatic micro-vasculature treated with estradiol benzoate in rats.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Estradiol; Liver; Liver Cirrhosis, Experimental; Methyld | 1990 |
Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats.
Topics: Adenine Nucleotides; Adenosine; Animals; Carbon Tetrachloride; Collagen; Fibrosis; Liver; Liver Cirr | 1990 |
Type I and type III procollagen peptides during hepatic fibrogenesis. An immunohistochemical and ELISA serum study in the CCl4 rat model.
Topics: Animals; Blood Chemical Analysis; Carbon Tetrachloride; Enzyme-Linked Immunosorbent Assay; Female; H | 1987 |
Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Colorimetry; Histocytochemistry; Liver; Liver Cirrhosis, Ex | 1989 |
[Effect of (+) cyanidanol-3 on experimental liver cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Female; Free Radica | 1989 |
[Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride; Cell Line; Colonic Ne | 1989 |
High levels of acetaldehyde in nonalcoholic liver injury after threonine or ethanol administration.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Animals; Carbon Tetrachloride; Dimethylnitrosamine; Ethanol; | 1989 |
Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbon Tetrachloride; Carcinoma, Squamous Cell; Female; L | 1989 |
Alterations of intestinal lymphatic system and mucosal immunity in CCl4-induced portal hypertensive rats.
Topics: Animals; Carbon Tetrachloride; Hypertension, Portal; Intestinal Mucosa; Intestine, Small; Liver Cirr | 1989 |
Functional changes of brain mitochondria during experimental hepatic encephalopathy.
Topics: Adenosine Triphosphatases; Ammonia; Animals; Brain Chemistry; Carbon Tetrachloride; Cytochromes; Fat | 1989 |
Propranolol decreases portal pressure without changing portocollateral resistance in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Cardiac Output; Collateral Circulation; Heart Rate; L | 1989 |
Carbon tetrachloride-induced experimental cirrhosis in the rat: a reappraisal of the model.
Topics: Amino Acids; Animals; Body Weight; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Liver | 1989 |
Increased serum type IV collagen peptide in carbon tetrachloride-treated rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Enzymes; Immunohistochemistry; Liver; Liver Cirrhosis, Expe | 1989 |
Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting.
Topics: Animals; Blood Volume; Carbon Tetrachloride; Collateral Circulation; Hemodynamics; Hemorrhage; Hyper | 1989 |
Orotic acid overproduction in experimental cirrhosis of rats.
Topics: Ammonia; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Orotic Acid; Rat | 1989 |
Mitochondrial function in carbon tetrachloride-induced cirrhosis in the rat. Qualitative and quantitative defects.
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Male; Mitochon | 1989 |
In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimental; Nuc | 1989 |
Thioacetamide- and carbon tetrachloride-induced liver cirrhosis.
Topics: Acetamides; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Lysosomes; Male; Ra | 1989 |
Alpha 1-antitrypsin and hepatic fibrosis.
Topics: alpha 1-Antitrypsin; Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Liver Dise | 1989 |
Lactate and pyruvate increase the incorporation of [3H]proline into collagen [3H]hydroxyproline in liver slices of CCl4 cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Cyclic AMP; Hydroxyproline; Lactates; Lactic Acid; Liver; L | 1987 |
Changes in concentrations of respiratory components and cytochrome oxidase activity in mitochondria obtained from carbon tetrachloride-induced cirrhotic rat liver.
Topics: Adenine Nucleotides; Animals; Carbon Tetrachloride; Electron Transport Complex IV; Humans; Liver Cir | 1988 |
Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase.
Topics: Animals; Carbon Tetrachloride; Collagen; Immunoenzyme Techniques; Immunohistochemistry; Liver; Liver | 1988 |
Changes in blood flow, portal pressure and shunting during the development of cirrhosis in response to beta-blockade.
Topics: Adrenergic beta-Antagonists; Animals; Carbon Tetrachloride; Dimethylnitrosamine; Liver; Liver Cirrho | 1987 |
Hepatotoxicity and metabolism of isoflurane in rats with cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Fluorides; Isoflurane; Liver; Liver C | 1989 |
Hepatic structural correlates of liver fibrosis: a morphometric analysis.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Female; Liver; Liver Cirrhosis, Experimental; Mitochond | 1989 |
Urea cycle enzyme activities are normal and inducible by a high-protein diet in CCl4 cirrhosis of rats.
Topics: Animals; Carbon Tetrachloride; Dietary Proteins; Liver Cirrhosis, Experimental; Male; Rats; Rats, In | 1989 |
Problems with animal models of chronic liver disease: suggestions for improvement in standardization.
Topics: Animals; Behavior, Animal; Carbon Tetrachloride; Chronic Disease; Disease Models, Animal; Hepatic En | 1989 |
[Scanning electron microscopical study of intrahepatic blood vessels during development of experimental cirrhosis in rats].
Topics: Animals; Carbon Tetrachloride; Female; Hepatic Artery; Hepatic Veins; Liver; Liver Cirrhosis, Experi | 1985 |
Alteration of thymus and of immune regulatory-antifibroblast factors in acute and chronic hepatic damage.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Count; Cell Division; Chronic Disease; Dimethylni | 1987 |
[Ultrastructural study of cells in the pseudolobules of experimental cirrhosis].
Topics: Animals; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimental; Male; Microvilli; Rats; | 1987 |
Anti-fibrotic effect of malotilate on liver fibrosis induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Collagen; Hydroxyproline; Liver Cirrhosis, Experimental; Male; Malona | 1986 |
[Study of the response of c-AMP, glucose and free fatty acids to stimulus with glucagon in rats in experimental hepatic cirrhosis].
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Cyclic AMP; Fatty Acids, Nonesterified; Glucagon; Live | 1987 |
Kinetic alterations of cytochrome c oxidase in carbon tetrachloride induced cirrhotic rat liver.
Topics: Adenosine Triphosphate; Animals; Carbon Tetrachloride; Cytochrome Reductases; Cytochrome-B(5) Reduct | 1987 |
Longitudinal study of renal prostaglandin excretion in cirrhotic rats: relationship with the renin-aldosterone system.
Topics: 6-Ketoprostaglandin F1 alpha; Aldosterone; Animals; Carbon Tetrachloride; Disease Models, Animal; Ki | 1988 |
Pancreatic endocrine function in cirrhotic rats.
Topics: Ammonia; Animals; Body Weight; Carbon Tetrachloride; Glucagon; Insulin; Islets of Langerhans; Liver | 1988 |
Heterogeneity of changes on the disposition of aspirin in rats with CCl4-induced chronic liver damage.
Topics: Aniline Hydroxylase; Animals; Aspirin; Carbon Tetrachloride; Carboxylic Ester Hydrolases; Colchicine | 1987 |
Diethyl-nitrosamine hepatocarcinogenesis in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Cirrhosis, Experimental; Liver Neoplasms, E | 1987 |
Potentiating effects of phenobarbitone on the induction of cirrhosis in rats by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Female; Liver; Liver Cirrhosis, Experimental; Necrosi | 1988 |
Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Synergism; Ethanol; Liver; Liver Cirrhos | 1988 |
Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis.
Topics: Animals; Carbon Tetrachloride; Galactose; Hemodynamics; Liver; Liver Cirrhosis, Experimental; Liver | 1988 |
[Kupffer cell-derived growth factor in fibroblasts in acute liver injury induced by carbon tetrachloride].
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibroblast Gro | 1988 |
Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats.
Topics: Adenine Nucleotides; Animals; Carbon Tetrachloride; Energy Metabolism; Kinetics; Lactates; Lactic Ac | 1988 |
Glutamate decarboxylase inhibition and vitamin B6 metabolism in brain of cirrhotic rats chronically treated with carbon tetrachloride.
Topics: Acetates; Animals; Brain; Carbon Tetrachloride; Enzyme Inhibitors; Glutamate Decarboxylase; Liver Ci | 1988 |
Ultrastructural study of cells in pseudolobules of the liver with experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Microvilli; Rats; Rats, Inbred | 1988 |
Experimental carbon tetrachloride-induced cirrhosis of the liver.
Topics: Animals; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimental; Rats; Rats, Inbred Stra | 1988 |
[Hepatic fibrosis and progesterone].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Carbo | 1988 |
Cell population kinetics of Kupffer cells during the onset of fibrosis in rat liver by chronic carbon tetrachloride administration.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cell Division; Histocytochemistry; Kinetics; Kupffer Cell | 1988 |
Effect of tryptophan on toxic cirrhosis induced by intermittent carbon tetrachloride intoxication in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimental; Necrosis; | 1988 |
Type IV collagen antigens in serum of rats with experimental fibrosis of the liver.
Topics: Animals; Antigens; Carbon Tetrachloride; Collagen; Female; Liver Cirrhosis, Experimental; Rats; Rats | 1987 |
Brain serotonin metabolism and behavior in rats with carbon tetrachloride-induced liver cirrhosis.
Topics: Animals; Behavior, Animal; Brain; Carbon Tetrachloride; Exploratory Behavior; Hepatic Encephalopathy | 1987 |
Polyamine biosynthesis and monooxygenase enzyme activity in rat liver cirrhosis and regeneration.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Cytochr | 1986 |
Insulin and glucagon production in experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Glucagon; In Vitro Techniques; Insulin; Liver Cirrhosis, Experimental | 1987 |
[Mechanisms of collagen resorption during the involution of liver cirrhosis].
Topics: Absorption; Animals; Carbon Tetrachloride; Collagen; Hepatectomy; Histocytochemistry; Liver; Liver C | 1987 |
Impaired androgen 16 alpha-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats.
Topics: Androgens; Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Cytochrome | 1987 |
Temporal relationship between the impairment of free water excretion and antidiuretic hormone hypersecretion in rats with experimental cirrhosis.
Topics: Animals; Ascites; Body Water; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Longitudinal Stud | 1987 |
Modulation of collagen synthesis by fat-storing cells, isolated from CCl4- or vitamin A-treated rats.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Collagen; Diterpenes; Endoplasmic Reticulum; Lipid M | 1987 |
Kupffer cell depletion associated with capillarization of liver sinusoids in carbon tetrachloride-induced rat liver cirrhosis.
Topics: Animals; Capillaries; Carbon Tetrachloride; Cell Count; Kupffer Cells; Liver; Liver Cirrhosis, Exper | 1987 |
Acute phase reactants enhance CCl4 induced liver cirrhosis in the rat.
Topics: Alanine Transaminase; Animals; C-Reactive Protein; Carbon Tetrachloride; Drug Synergism; Glutamate D | 1986 |
[Suppressive effect of tritoqualine (TRQ) on the acceleration of fibrosis in the liver].
Topics: Animals; Carbon Tetrachloride; Collagen; Histamine; Isoquinolines; Liver; Liver Cirrhosis, Experimen | 1986 |
Effect of malotilate on chronic liver injury induced by carbon tetrachloride in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride; Chronic Disease; Collagen; Liver; Liver Cirrhosis, Exper | 1986 |
Changes in prolinase and prolidase activity during CCl4 administration inducing liver cytolysis and fibrosis in rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Dipeptidases; Fibr | 1987 |
[Collagen resorption by macrophages and fibroblasts in liver cirrhosis].
Topics: Absorption; Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Histocytochemistry; Liver Cirrhosi | 1985 |
Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Liver; Liver Cirrhosis, Experimental; Male; Methods; | 1985 |
Hypergammaglobulinemia in experimental liver injury.
Topics: Animals; Blood Protein Disorders; Carbon Isotopes; Carbon Tetrachloride; Electrophoresis; gamma-Glob | 1967 |
[The influence of cortisone on proliferation and metabolism of the connective tissue in the experimental cirrhosis of the liver].
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Connective Tissue; Glucosamine; Glycosaminoglycans; | 1969 |
The role of perisinusoidal cells in experimental hepatic fibrogenesis.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; En | 1972 |
The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Ethanol; Fatty Li | 1971 |
Effect of angiotensin on water and electrolyte excretion in normal and cirrhotic rats.
Topics: Anesthesia; Angiotensin II; Animals; Carbon Tetrachloride; Diuresis; Ethanol; Liver Cirrhosis, Exper | 1972 |
Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury.
Topics: Animals; Carbon Tetrachloride; Collagen; Female; Galactose; Glucosyltransferases; Hexosyltransferase | 1974 |
Hepatic zinc concentrations in experimental cirrhosis induced with carbon tetrachloride and phenobarbitone.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Spec | 1974 |
Albumin content of hepatocytes in experimental cirrhosis.
Topics: Albumins; Animals; Carbon Tetrachloride; Fluorescent Antibody Technique; Liver; Liver Cirrhosis, Exp | 1972 |
[Electron microscopic study of the reversibility of sclerotic changes in the liver].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Collagen; Connective Tissue; Connecti | 1974 |
The effects of azathioprine on CCl4 induced cirrhosis in the rat.
Topics: Adenosine Triphosphate; Animals; Azathioprine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1974 |
Studies on iron absorption. VII. Iron absorption in rats with carbon tetrachloride (CCl4) induced damage and cirrhosis of the liver.
Topics: Absorption; Animals; Carbon Tetrachloride; Iron; Liver; Liver Cirrhosis, Experimental; Rats | 1967 |
Phagocytic activity in experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Division; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; M | 1968 |
Modification of chronic carbon tetrachloride hepatic injury by N,N'-diphenyl-p-phenylenediamine.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Necrosis; P | 1968 |
Porta-pulmonary venous anastomoses in experimental cirrhosis of the liver in rats.
Topics: Animals; Arteries; Barium Sulfate; Carbon Tetrachloride; Coronary Vessels; Esophagus; Hypoxia; Liver | 1972 |
[Liver cell regeneration during the development of liver cirrhosis in rats, induced by tetrachlormethane].
Topics: Animals; Carbon Tetrachloride; Histocytochemistry; Liver; Liver Cirrhosis; Liver Cirrhosis, Experime | 1971 |
Development of tumor in the course of spontaneous restoration of carbon tetrachloride induced cirrhosis of the liver in rats.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Liver Neoplasms; Rats | 1965 |
Influence of cirrhosis on production of atheroarteriosclerosis and thromboarteritis with vitamin D and dietary cholesterol.
Topics: Animals; Arteries; Arteriosclerosis; Bilirubin; Carbon Tetrachloride; Diet; Hypercholesterolemia; Li | 1969 |
Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.
Topics: Animals; Ascites; Carbon Tetrachloride; Gases; Hypertension, Portal; Liver Cirrhosis, Experimental; | 1969 |
A rapid method for producing cirrhosis of the liver in rats and its effect on microsomal enzyme activity.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Methods; Microsomes, Liver; Phenobarbi | 1970 |
Hepatic vein thrombosis. Increased incidence in rats given methylcholanthrene and carbon tetrachloride.
Topics: Age Factors; Animals; Budd-Chiari Syndrome; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Fe | 1970 |
Induced regeneration of the rat liver during experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Hepatectomy; Liver Cirrhosis, Experimental; Liver Regeneration; Male; | 1968 |
Effect of liver regeneration on the portal pressure and vascular pattern in normal and cirrhotic rats.
Topics: Animals; Blood Pressure Determination; Carbon Tetrachloride; Collagen; DNA; Hepatectomy; Hypertensio | 1968 |
[Characteristics of experimental liver cirrhosis related to the age of the animal].
Topics: Aging; Animals; Bile; Carbon Tetrachloride; DNA; Fatty Liver; Glycogen; Lipid Metabolism; Liver; Liv | 1968 |
[Zn 65 uptake in the cirrhotic liver of rats treated with carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Chronic Disease; Kidney; Liver; Liver Cirrhosis, Experimental; Rats; | 1968 |
In numero studies in a cell renewal system. Periodically adjusted cell renewal process.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Computers; DNA; Kinetics; Liver Cirrhosis; Liver Cir | 1965 |
Hepatic vascular changes in human and experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Hepatic Artery; Hepatic Veins; Humans; Liver Circulation; Liver Cirrh | 1966 |