carbon tetrachloride has been researched along with Chemical and Drug Induced Liver Injury in 1972 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxymatrine (OMT) is able to effectively protect against hepatic fibrosis because of its anti-inflammatory property, while the underlying mechanism remains incompletely understood." | 7.83 | Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. ( Bai, ZF; Chai, X; Cui, HR; Li, GQ; Li, RS; Liu, HM; Meng, YK; Wang, HB; Wang, JB; Xiao, XH; Zhang, ZF; Zhao, HW, 2016) |
| "Launaea procumbens methanol extract (LPME) was evaluated against carbon tetrachloride (CCl4)-induced pancreatic oxidative damage and hyperglycemia in rats." | 7.81 | Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study. ( Ahmed, M; Khan, MR; Khan, RA; Sahreen, S; Shah, NA, 2015) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 7.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| " In this study, we investigated the role of Pin1 in carbon tetrachloride (CCl(4))-induced apoptosis and necrosis of hepatocytes during acute liver injury of mice." | 7.78 | Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. ( Cho, BH; Jeong, YJ; Kim, JC; Park, BH; Risal, P, 2012) |
| " In this study, we investigated whether 3-genes iPSC transplantation is capable of rescuing carbon tetrachloride (CCl(4))-induced fulminant hepatic failure and hepatic encephalopathy in mice." | 7.78 | Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. ( Chang, HM; Chang, YL; Chen, HL; Chen, LK; Chen, SY; Chen, YJ; Chiang, CH; Chien, Y; Hsieh, JH; Huo, TI; Jeng, SY; Lai, YH; Li, HY; Liao, YW; Peng, CH, 2012) |
| " The study also investigated the ability of MHN-02 to attenuate lethality, liver injury, the production of inflammatory cytokines, and the production of oxidized products using a carbon tetrachloride-induced rat model of severe fulminant hepatitis." | 7.77 | A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis. ( Asai, K; Azami, T; Hirate, H; Kawashima, A; Mizuochi, Y; Sasaki, H; Sobue, K; Sugiura, T; Takayanagi, T, 2011) |
| "pDNA was instilled onto the liver surface in normal and carbon tetrachloride-induced hepatitis mice." | 7.77 | Safety of liver surface instillation of plasmid DNA in normal and carbon tetrachloride-induced hepatitis mice. ( Fumoto, S; Furukawa, H; Nakamura, J; Nishida, K, 2011) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 7.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 7.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "Fluphenazine (FP) treatment (50 mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 7.69 | Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis. ( Bernacchi, AS; Castro, GD; Castro, JA; de Ferreyra, EC; San Martin, MF, 1995) |
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 7.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| "Hepatic granulomas induced by a single or several subcutaneous injections of carbon tetrachloride (CCl4) in Balb/c mice were examined electronmicroscopically and immunocytochemically." | 7.68 | Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride. ( Lukita-Atmadja, W; Sato, T; Wake, K, 1993) |
| "Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives." | 7.67 | Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model. ( Bodor, N; Brey, W; el Koussi, A; Houck, HJ; Loftsson, T; Raad, I; Rand, KH; Rocca, J, 1987) |
| "Studies in the rat with hepatic necrosis induced by carbon tetrachloride showed that the abnormalities in one-stage coagulation tests and the increased catabolism of fibrinogen were similar to those found in man with acute viral or drug-induced hepatic necrosis." | 7.65 | Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen. ( Flute, PT; Pannell, G; Rake, MO; Shilkin, KB; Williams, R, 1973) |
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 6.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| " The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days." | 5.36 | Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity. ( Anuradha, CV; Pooranaperundevi, M; Sumiyabanu, MS; Sundarapandiyan, R; Viswanathan, P, 2010) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 5.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 5.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| "CCl4 produced hepatocellular necrosis." | 5.29 | Effects of alcohol, carbon tetrachloride, and choline deficiency on iron metabolism in the rat. ( Batey, RG; Johnston, R, 1993) |
| "The mechanism of carbon tetrachloride (CCl4)-induced hepatotoxicity, especially necrosis and fatty liver, has long been a challenging subject of many researchers from various fields over the past 50 years." | 4.83 | [Learning toxicology from carbon tetrachloride-induced hepatotoxicity]. ( Masuda, Y, 2006) |
| "One of the principles of prevention and non-medicamentous treatment of liver diseases, including hepatitis of different etiology, is the normalization of the diet through the consumption of food with physiologically active ingredients, in particular betulin, which helps to eliminate the causes of metabolic and oxidative disorders within liver cells." | 4.31 | [Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis]. ( Averyanova, EV; Chugunova, OV; Mazko, ON; Shkolnikova, MN, 2023) |
| " The animals were divided into five groups: control group (the rats were simulated carbon tetrachloride poisoning and its correction by administering of olive oil and normal saline in equivalent doses), acute carbon tetrachloride hepatitis (single intraperitoneal injection of 50% carbon tetrachloride oil solution at the dose of 2 ml/kg-1 of body weight and simulation of treatment by administration of normal saline in equivalent doses), acute carbon tetrachloride hepatitis + L-ornithine (1000 mg×kg-1), acute carbon tetrachloride hepatitis + L-arginine (500 mg×kg-1) and acute carbon tetrachloride hepatitis + combination of substances." | 4.02 | Assessment of nitrogen metabolism in rats on the background of acute toxic hepatitis and it's correction with l-arginin and l-ornitin. ( Danchak, SV; Krekhovska-Lepiavkob, OM; Lokay, BA; Mazur, LP; Yastremska, SO, 2021) |
| "Norfloxacin administration is useful in preventing bacterial infections in cirrhosis but associated to the generation of resistant species." | 3.88 | Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis. ( Bellot, P; Francés, R; García, I; Gimenez, P; Gómez-Hurtado, I; González-Navajas, JM; Guarner, F; Manichanh, C; Ramos, JM; Such, J; Zapater, P, 2018) |
| " As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP against carbon tetrachloride (CCl4)-induced liver injury." | 3.85 | Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. ( Bao, X; Brenner, DA; Cong, M; Fan, X; Jia, J; Kisseleva, T; Liu, T; Wang, P; You, H; Zhai, Q; Zhang, D; Zhao, W; Zhuang, H, 2017) |
| " Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment." | 3.83 | CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. ( Aldridge, V; Buckley, CD; Croft, AP; Fear, J; Garg, A; Haldar, D; Hedegaard, D; Henderson, NC; Naylor, AJ; Newsome, PN; Reynolds, GM; Weston, CJ; Wilhelm, A, 2016) |
| "Oxymatrine (OMT) is able to effectively protect against hepatic fibrosis because of its anti-inflammatory property, while the underlying mechanism remains incompletely understood." | 3.83 | Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. ( Bai, ZF; Chai, X; Cui, HR; Li, GQ; Li, RS; Liu, HM; Meng, YK; Wang, HB; Wang, JB; Xiao, XH; Zhang, ZF; Zhao, HW, 2016) |
| "Launaea procumbens methanol extract (LPME) was evaluated against carbon tetrachloride (CCl4)-induced pancreatic oxidative damage and hyperglycemia in rats." | 3.81 | Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study. ( Ahmed, M; Khan, MR; Khan, RA; Sahreen, S; Shah, NA, 2015) |
| " Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure." | 3.80 | Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure. ( Azarnia, M; Ghasemi, M; Jamali, M; Mirabolghasemi, G; Naghizadeh, MM; Nazarian, S; Rajabi, M; Tahamtani, Y, 2014) |
| " Carbon tetrachloride (CCl4) treatment can cause steatosis in rats that models both alcoholic and non-alcoholic fatty liver disease in humans." | 3.80 | Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation. ( Dai, MG; Dai, N; Wang, HF; Zhu, L; Zou, Y, 2014) |
| " After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
| " DPP8 and DPP9 expression were measured in epidermal growth factor (EGF) treated Huh7 hepatoma cells, in fibrotic liver samples from mice treated with carbon tetrachloride (CCl₄) and from multidrug resistance gene 2 (Mdr2/Abcb4) gene knockout (gko) mice with biliary fibrosis, and in human end stage primary biliary cirrhosis (PBC)." | 3.79 | Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. ( Ajami, K; Bertolino, P; Chen, Y; Chowdhury, S; Gorrell, MD; McCaughan, GW; Popov, Y; Schuppan, D; Wang, XM; Yao, TW; Yu, DM, 2013) |
| "The aim of the present work is to investigate the potential of Physalis peruviana fruits as a hepatorenal protective agent against carbon tetrachloride (CCl4)-induced hepatic and renal fibrosis." | 3.79 | Golden berry juice attenuates the severity of hepatorenal injury. ( El-Gengaihi, SE; Hamed, MA; Khalaf-Allah, Ael-R; Mohammed, MA, 2013) |
| " In this study, we investigated the role of Pin1 in carbon tetrachloride (CCl(4))-induced apoptosis and necrosis of hepatocytes during acute liver injury of mice." | 3.78 | Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. ( Cho, BH; Jeong, YJ; Kim, JC; Park, BH; Risal, P, 2012) |
| "To study the mechanism of liver injury induced by carbon tetrachloride (CCl(4)) in rats with non-alcoholic fatty liver disease (NAFLD), and the therapeutic effects of the extract mixture of Dangyao (Swertia pseudochinensis Hara) and Shuifeiji (Silybum marianum Gaertn) on NAFLD rats with liver injury." | 3.78 | [Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease]. ( Ji, G; Li, DF; Liu, P; Liu, T; Mao, ZM; Song, HY; Yang, LL; Zheng, PY, 2012) |
| " In this study, we investigated whether 3-genes iPSC transplantation is capable of rescuing carbon tetrachloride (CCl(4))-induced fulminant hepatic failure and hepatic encephalopathy in mice." | 3.78 | Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. ( Chang, HM; Chang, YL; Chen, HL; Chen, LK; Chen, SY; Chen, YJ; Chiang, CH; Chien, Y; Hsieh, JH; Huo, TI; Jeng, SY; Lai, YH; Li, HY; Liao, YW; Peng, CH, 2012) |
| " Carbon tetrachloride and methionine/choline deficiency were used as chronic liver injury models." | 3.77 | Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. ( Beaven, SW; Bensinger, S; Hong, C; Tontonoz, P; Tsukamoto, H; Wang, J; Wroblewski, K, 2011) |
| " The study also investigated the ability of MHN-02 to attenuate lethality, liver injury, the production of inflammatory cytokines, and the production of oxidized products using a carbon tetrachloride-induced rat model of severe fulminant hepatitis." | 3.77 | A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis. ( Asai, K; Azami, T; Hirate, H; Kawashima, A; Mizuochi, Y; Sasaki, H; Sobue, K; Sugiura, T; Takayanagi, T, 2011) |
| "pDNA was instilled onto the liver surface in normal and carbon tetrachloride-induced hepatitis mice." | 3.77 | Safety of liver surface instillation of plasmid DNA in normal and carbon tetrachloride-induced hepatitis mice. ( Fumoto, S; Furukawa, H; Nakamura, J; Nishida, K, 2011) |
| " Liver oxidative stress and inflammation were examined by detecting the liver malondialdehyde level and glutathione and superoxide dismutase activity, and serum tumour necrosis factor-alpha level, respectively." | 3.76 | Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice. ( Dong, W; Hao, X; Ren, X; Yan, F; Yang, L, 2010) |
| "6 g/kg bw) significantly reduced the serum levels of alanine aminotransferase and aspartate aminotransferase in rats treated with CCl4, and also decreased the thiobarbituric acid reactive substances, hydroxyproline and excessive inflammation in the livers of CCl4-treated rats." | 3.76 | Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats. ( Hsu, CC; Hsu, CL; Yen, GC, 2010) |
| " The prolongation of narcolepsy induced by pentobarbital was shortened significantly by the extract." | 3.76 | The effectiveness of ethanolic extract of Amaranthus tricolor L.: A natural hepatoprotective agent. ( Al-Dosari, MS, 2010) |
| " In this study, apolipoprotein E-deficient (ApoE-/-) mice were evaluated to define potential effects of hypercholesterolemia on the severity of carbon tetrachloride (CCl4)-induced liver injury." | 3.75 | Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. ( Arroyo, V; Bataller, R; Camps, J; Clària, J; Ferré, N; González-Périz, A; Guardiola, F; Horrillo, R; Joven, J; López-Parra, M; Martínez-Clemente, M; Planagumà, A; Tres, A, 2009) |
| "We investigated the effect of human umbilical mesenchymal stem cells (HUMSCs) from Wharton's jelly on carbon tetrachloride (CCl4)-induced liver fibrosis in rats." | 3.75 | The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. ( Chen, TH; Chen, YM; Fu, TW; Fu, YS; Hung, SC; Ko, TL; Shih, YH; Tsai, PC, 2009) |
| "The liver injury in the model rat was induced by alpha-naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl(4) ) respectively, and the effects of Yinchenhao Decoction (, YCHD), a proved effective Chinese medical formula for treating the dampness-heat jaundice syndrome in clinic, on the two liver injury models were evaluated by analyzing the serum level of alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), malondialchehyche (MDA), total bilirubin (T-BIL), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) as well as the ratio of liver weight to body weight." | 3.75 | Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride. ( Cao, HX; Jiang, XG; Liu, L; Lu, HT; Sun, H; Sun, WJ; Wang, P; Wang, XJ; Wu, ZM; Zhang, GM; Zhou, J, 2009) |
| " In our present study, an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) method has been established and validated for simultaneous quantitation of 22 BAs and a metabonomic study was performed based on the chemometric analysis of the serum samples from carbon tetrachloride (CCl4)- and alpha-naphthylisothiocyanate (ANIT)-induced liver failure rats." | 3.74 | Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. ( He, Y; Hu, Z; Li, W; Wang, C; Wang, Z; Xiong, A; Yang, L, 2008) |
| " Ten weeks of carbon tetrachloride injections caused subacute hepatic damage, manifested as significantly less body weight gain and hepatic protein content, and a higher liver weight, serum aspartate aminotransferase and alanine aminotransferase levels, hepatic malondialdehyde (an index for lipid peroxidation), and hydroxyproline (an index for collagen synthesis) concentrations." | 3.74 | Hepatoprotective effects of Artemisiae capillaris herba and Picrorrhiza rhizoma combinations on carbon tetrachloride-induced subacute liver damage in rats. ( Kim, HH; Ku, SK; Lee, HS, 2008) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 3.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| " The results indicated that long-term VI-28 treatment invariably protected against oxidative tissue damage in the rat models of cerebral/myocardial ischemia-reperfusion injury, CCl4 hepatotoxicity, and gentamicin nephrotoxicity." | 3.74 | Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. ( Chen, N; Chiu, PY; Ko, KM; Leung, HY; Poon, MK; Siu, AH, 2008) |
| " In leptin-deficient mice, it was associated with exaggerated activation of NF-kappa B and STAT3 during the priming phase, abrogation of tumor necrosis factor (TNF) and interleukin (IL)-6 release at the time of G1/S transition, and failure of hepatocyte induction of cyclin D1 and cell cycle entry." | 3.72 | Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. ( Farrell, GC; Field, J; Leclercq, IA, 2003) |
| " The cytoprotective effect of central TRH on CCl(4)-induced acute hepatocellular necrosis was abolished by hepatic branch vagotomy, atropine, indomethacin and N(G)-nitro-L-arginine methyl ester, but not by 6-hydroxydopamine." | 3.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| "5% inhibition on the vascular permeability change induced by intraperitoneal injection of acetic acid, but it could not inhibit croton oil-induced ear edema." | 3.71 | Anti-oxidative, anti-inflammatory and hepato-protective effects of Ligustrum robustum. ( But, PP; Dong, H; Fung, KP; He, ZD; Lau, KM, 2002) |
| "When carbon tetrachloride (CCl4) was administered to rats, a localized region of hepatic edema could be detected within 1 h by in vivo proton magnetic resonance imaging." | 3.69 | In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl4-induced hepatotoxicity in rats. ( Janzen, EG; Reinke, LA; Towner, RA; Yamashiro, S, 1994) |
| "Fluphenazine (FP) treatment (50 mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 3.69 | Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis. ( Bernacchi, AS; Castro, GD; Castro, JA; de Ferreyra, EC; San Martin, MF, 1995) |
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 3.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| " In this study, we describe a rat model of fatigue assessment using a swim tank, and we used this model to document the degree of fatigue in rat models of cholestasis caused by bile duct resection (BDR) and of hepatitis caused by carbon tetrachloride (CCl4) administration." | 3.69 | Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. ( Maric, M; Swain, MG, 1997) |
| "Hepatic granulomas induced by a single or several subcutaneous injections of carbon tetrachloride (CCl4) in Balb/c mice were examined electronmicroscopically and immunocytochemically." | 3.68 | Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride. ( Lukita-Atmadja, W; Sato, T; Wake, K, 1993) |
| "The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl4)-induced hepatotoxicity in mice." | 3.68 | Protective effects of tetrahydroneopterin against free radical-induced injury. ( Icho, T; Kajiwara, Y; Kitabatake, K; Kojima, S; Kubota, K; Shinohara, N, 1993) |
| "Hepatic necrosis produced by carbon tetrachloride (0." | 3.68 | Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine. ( Harbison, RD; James, RC; Roberts, SM; Seng, JE, 1991) |
| "Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip." | 3.68 | Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats. ( Garg, KN; Mehrotra, GC; Singh, J, 1990) |
| "Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives." | 3.67 | Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model. ( Bodor, N; Brey, W; el Koussi, A; Houck, HJ; Loftsson, T; Raad, I; Rand, KH; Rocca, J, 1987) |
| " Similar findings were obtained in rats with CCl4 liver damage or gentamicin nephrotoxicity, except that those rats hardly exhibited anemia because of a simultaneous occurrence of hemoconcentration." | 3.67 | The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats. ( Furuhama, K; Igarashi, K; Kato, M; Onodera, T; Suzuki, N, 1987) |
| " Centrilobular necrosis and marked elevation of serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) activities were induced by carbon tetrachloride (0." | 3.67 | Potentiation of carbon tetrachloride hepatotoxicity by hypoxia. ( Shibayama, Y, 1986) |
| "We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma." | 3.67 | An investigation into the association between liver damage and metastatic uveal melanoma. ( Albert, DM; Fournier, GA; Hatfield, RM; Pascal, SG; Saulenas, AM; Seddon, JM, 1985) |
| "A rat model of enflurane-associated hepatotoxicity was compared with the halothane-hypoxia (HH) model (adult male rats, phenobarbital induction, 1% halothane, 14% O2, for 2 hr)." | 3.67 | Comparison of the requirements for hepatic injury with halothane and enflurane in rats. ( Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG, 1985) |
| "Studies in the rat with hepatic necrosis induced by carbon tetrachloride showed that the abnormalities in one-stage coagulation tests and the increased catabolism of fibrinogen were similar to those found in man with acute viral or drug-induced hepatic necrosis." | 3.65 | Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen. ( Flute, PT; Pannell, G; Rake, MO; Shilkin, KB; Williams, R, 1973) |
| "Sixty chronic active hepatitis patients complicated with hyperbilirubinemia (total bilirubin > 171 mumol/L) were treated with combined treatment of Ganyan IV and Western medicine." | 2.68 | [Clinical and experimental study on effect of ganyan IV in treatment of chronic active hepatitis complicated with hyperbilirubinemia]. ( Hu, YH; Liao, ZR; Zou, GM, 1996) |
| "Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other organs and many studies confirm its benefits against oxidative stress including lipid peroxidation, protein mutilation and molecular degeneration in various organs, including the liver." | 2.53 | Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review. ( Alatorre-Jiménez, MA; Almeida-Souza, P; Cantín-Golet, A; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Reiter, RJ; Reyes-Gonzales, MC; Ruiz-Ruiz, FJ; Tan, DX, 2016) |
| "It is often assumed that at a younger age populations are at higher risk of toxic effects from exposure to toxic chemicals." | 2.39 | Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity. ( Dalu, A; Mehendale, HM, 1996) |
| " It appears that a greater bioactivation of CCl4 in chlordecone treated animals resulted in an initial potentiation of toxic events in the liver cells." | 2.37 | Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride. ( Mehendale, HM, 1984) |
| "Most adverse drug reactions affecting the liver and producing jaundice are unpredictable, delayed in onset, and only hypothetically related to microsomal metabolism in some instances." | 2.35 | Hepatic drug metabolism and adverse hepatic drug reactions. ( Schaffner, F, 1975) |
| " Rodent models of D-GalN-induced fibrosis are not recommended due to the long incubation period and weak toxic effect." | 1.91 | Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity. ( Bogunia, E; Czekaj, P; Grajoszek, A; Hermyt, M; Kolanko, E; Król, M; Limanówka, Ł; Michalik, M; Pająk, J; Prusek, A; Sikora, B; Skubis-Sikora, A, 2023) |
| " Hepatic cell injury occurs by the activation of reactive oxygen species (ROS) that are generated by carbon tetrachloride (CCl4), xenobiotics, and other toxic substances through cytochrome P450-dependent steps resulting from the covalent bond formation with lipoproteins and nucleic acids." | 1.91 | An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity. ( Afrin, SS; Aktar, F; Akter, T; Amran, MS; Anjum, J; Bahar, NB; Chowdhury, AA; Chowdhury, JA; Jahan, I; Kabir, S; Koly, FJ; Reza, MS; Sen, P; Sultana, A; Tahsin, MR; Tasnim, S; Tithi, TI; Zaman, TS, 2023) |
| " However, rats fed with CPS exhibited mitigation of CCl4-induced toxic effects on hematological parameters and hepatotoxicity." | 1.91 | Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity. ( Abdel-Hameed, SM; Gazwi, HSS; Soltan, OIA, 2023) |
| "The changes that follow liver fibrosis were assessed by measurement of hepatic enzymes (ALT, AST and ALP), histopathological examination using hematoxylin and eosin stain, special stains, and α-smooth muscle actin (α-SMA) immunostaining, measuring oxidative stress markers (MDA, GSH, NOx and MnSOD) and transforming growth factor-beta 1 (TGF-β1) in liver." | 1.72 | Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride. ( Ahmed, AA; Ahmed, MA; El-Bakry, MH; Hasan, A; Omar, ZMM, 2022) |
| "Post quercetin treatment improved liver function parameters in the hepatotoxic Wistar rats by augmenting bilirubin content, SGOT and SGPT activity." | 1.72 | Nonlinear molecular dynamics of quercetin in Gynocardia odorata and Diospyros malabarica fruits: Its mechanistic role in hepatoprotection. ( Alkahtani, S; Baishya, D; Ghosh, A; Mishra, R; Mukerjee, N; Patel, H; Sarmah, P; Varma, RS, 2022) |
| "Carbon tetrachloride (CCl4) is a dynamic environmental toxin released from chemical factories and its concentration in the atmosphere is accelerating at an alarming proportion." | 1.72 | Phytochemical Screening and Protective Effects of Prunus persica Seeds Extract on Carbon Tetrachloride-Induced Hepatic Injury in Rats. ( Butt, AM; Ijaz, B; Nazar, R; Qamar, R; Rehman, S; Shah, SM; Shahid, I; Sheikh, AK; Tasawar, N, 2022) |
| "Chronic hepatitis B (CHB) patients with liver fibrosis were enrolled and assigned to receive either nucleoside/nucleotide analogues (NAs) or NAs plus YQHX." | 1.62 | Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling. ( Dong, S; Hou, M; Li, L; Li, W; Liu, L; Nan, Y; Tang, Y; Zhang, X; Zhang, Y; Zhao, D; Zhao, W, 2021) |
| "Canagliflozin (CANA) is a sodium-glucose cotransporter 2 inhibitor that was recently approved for treating diabetes." | 1.62 | Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase. ( Ding, Y; Dong, R; Meng, S; Wang, H; Wang, S; Yin, L, 2021) |
| "However, successful therapy for liver fibrosis is still lacking." | 1.62 | Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl ( Ding, Y; Huang, C; Li, J; Ma, T; Xu, S; Zhang, Y; Zhao, H; Zhu, H, 2021) |
| "Ursolic acid (UA) is a potent plant-based hepatoprotective agent having poor bioavailability, which hampers its therapeutic efficacy." | 1.62 | Synergistic effect of ursolic acid and piperine in CCl ( Biswas, S; Haldar, PK; Kar, A; Mukherjee, PK; Sharma, N, 2021) |
| " Groups D, E, and F were intragastrically dosed with ZQRGD." | 1.62 | Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis. ( Che, JY; Chen, TT; He, J; He, Y; Shao, M; Shi, LP; Wang, J; Xie, T; Yuan, Z; Zhou, M, 2021) |
| "Liver fibrosis is the result of an excessive accumulation of extracellular matrix that develops when inflammation and chronic injury form scar tissue in the liver." | 1.62 | Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice. ( A M Alameen, A; Alzahrani, B; Tantawy, A, 2021) |
| " Nevertheless, low solubility and bioavailability hamper the application of SA." | 1.56 | Development of TPGS/F127/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity. ( Adu-Frimpong, M; Deng, W; Li, W; Li, Y; Ma, P; Sun, C; Xu, X; Yu, J; Zhang, H; Zhu, Y, 2020) |
| "The present work investigated anti-prostate cancer and hepatoprotective activities of flavonoid derivatives from H." | 1.56 | Isolation and characterization of flavonoid derivatives with anti-prostate cancer and hepatoprotective activities from the flowers of Hosta plantaginea (Lam.) Aschers. ( He, J; Ma, Q; Sang, Z; Wei, R; Zhong, G, 2020) |
| "To investigate comparative in vitro and in vivo performance of lipid vesicular and particulate systems in escalating oral bioavailability for superior hepatoprotection." | 1.56 | Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. ( Dhawan, V; Fahr, A; Lokras, A; Nagarsenker, M; Saraf, M; Sutariya, B; Thamm, J; Warawdekar, U, 2020) |
| "Apigenin (APG) is a flavonoid, which exhibits efficient anti-liver fibrosis activity, but its underlying mechanisms were rarely studied." | 1.56 | Transcriptomics and proteomics analysis of system-level mechanisms in the liver of apigenin-treated fibrotic rats. ( Hu, J; Qiao, M; Yang, J; Zhao, Y; Zhu, Y, 2020) |
| "The poncirin treatment was also evaluated against the pro-inflammatory cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) using enzyme link immunosorbant assay (ELISA)." | 1.56 | Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice. ( Ahmed, N; Ali, H; Baig, MW; Khan, A; Khan, S; Tipu, MK; Ullah, H; Ullah, N, 2020) |
| "Baicalein has shown extensive bioactivity." | 1.56 | A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis. ( Li, P; Li, Q; Wang, Y; Yu, Z, 2020) |
| "The current research on the treatment of liver fibrosis mainly focuses on the activation of hepatic stellate cell, in addition to protecting liver cells." | 1.56 | Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice. ( Bai, J; Bi, Z; Li, H; Li, X; Ma, B; Ma, X; Ning, W; Shao, S; Wei, Y; Xie, C; Yang, C; Zhang, L; Zhang, R; Zhang, S; Zhou, H, 2020) |
| "Liver fibrosis will develop into liver cirrhosis unless the damaging factors are removed." | 1.56 | Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis. ( Guan, W; Lai, J; Lu, H; Sun, Y; Wu, X; Zhang, S, 2020) |
| "8) against the toxic group (51." | 1.56 | Hepatoprotective and antioxidant activity of Dicliptera bupleuroides Nees. extracts on paracetamol induced hepatotoxicity in rats. ( Akbar, S; Bushra, R; Ghayas, S; Hussain, K; Ishtiaq, S, 2020) |
| "Berberine (BBR) is an isoquinoline alkaloid, reported to have multiple pharmacological functions." | 1.51 | Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways. ( Gu, JG; Han, CY; Liu, CY; Sun, TT; Wang, SS; Xv, GP, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to liver injury caused by stimulants such as drugs and poisons." | 1.51 | Jiang-Zhi granules decrease sensitivity to low-dose CCl ( Song, H; Yang, L; Zheng, P; Zhou, Y, 2019) |
| " However, these bioactivities have been hampered by chemical instability, poor water solubility, rapid metabolism, and low bioavailability of PAP." | 1.51 | Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol-bound punicic acid for increased antihepatotoxic activity. ( Adu-Frimpong, M; Deng, W; Firempong, CK; Mukhtar, YM; Omari-Siaw, E; Wang, Q; Xu, X; Yu, J; Yu, Q, 2019) |
| "Rosiglitazone (RGZ) is a highly potent agonist of PPARγ." | 1.51 | Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis. ( Chen, SZ; Li, JJ; Li, YY; Yu, FX; Zheng, YH; Zhi, SC, 2019) |
| "To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal model." | 1.51 | Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex. ( Bannerjee, S; Bhattacharjee, P; Biswas, S; Harwansh, RK; Mukherjee, PK, 2019) |
| " However, close attention should be paid to the possible side effects and oral dosage of YCHT in clinics." | 1.51 | Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl ( Chen, M; Hu, P; Huang, C; Liu, F; Liu, H; Pan, G; Peng, H; Qiao, S; Tian, X; Wang, Y; Yin, H, 2019) |
| "Results indicate that the treatment of BM-MSCs in combination with silymarin had a better hepatoprotective and antimutagenic effect and represents a novel strategy for the treatment of hepatotoxicity." | 1.51 | Human bone marrow-derived mesenchymal stromal cells in combination with silymarin regulate hepatocyte growth factor expression and genotoxicity in carbon tetrachloride induced hepatotoxicity in Wistar rats. ( Aithal, AP; Bairy, LK; Rao, MK; Seetharam, RN, 2019) |
| "As the first step in revealing the hepatoprotective chemical base of YCHT, we aimed to clarify the absorbed ingredients and associated metabolic pathways for orally dosed YCHT in both normal and liver injury rats from a liver-centric perspective." | 1.51 | Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl ( Chen, M; Hu, P; Huang, C; Liu, F; Liu, H; Tian, X; Wang, Y; Yin, H, 2019) |
| " However, the bioavailability of FA is not optimal, owing to its limited aqueous solubility." | 1.51 | Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex. ( Hsu, CM; Tsai, FJ; Tsai, Y; Yu, SC, 2019) |
| "Ketoconazole pretreatment adult male rats were intraperitoneally injected with carbon tetrachloride for 24 hr and various hepatic parameters were analyzed." | 1.51 | Ketoconazole pretreatment ameliorates carbon tetrachloride-induced acute liver injury in rats by suppressing inflammation and oxidative stress. ( Huang, K; Peng, C; Zhou, Y; Zhou, Z, 2019) |
| "Cuminaldehyde self-emulsified nanoemulsion (CuA-SEN) was prepared and optimised to improve its oral bioavailability and antihepatotoxicity." | 1.51 | Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice. ( Adu-Frimpong, M; Firempong, CK; Lijun, Z; Mukhtar, YM; Omari-Siaw, E; Qiuyu, W; Xu, X; Yang, Q; Yu, J, 2019) |
| "Ketoconazole is a first orally available anti-fungal drug which has been reported as a potent inhibitor of human cytochrome P-450." | 1.51 | Hepatoprotective effect of ketoconazole in chronic liver injury model. ( Ahmed, M; Akhtar, U; Ali, G; Shehzad, U; Tayyeb, A, 2019) |
| "Malondialdehyde (MDA) levels were decreased by 20." | 1.51 | Effect of Camellia sinensis, Hypericum perforatum and Urtica dioica on kidney and liver injury induced by carbon tetrachloride in rats. ( Caglar, HG; Demirel, M; Koktasoglu, F; Koyuncu, I; Meydan, S; Sarikaya, A; Selek, S, 2019) |
| "An animal model of chronic liver failure was developed, and undifferentiated human cord blood mesenchymal stem cells, in vitro hepato-genically differentiated mesenchymal stem cells, or freshly isolated rat hepatocytes were transplanted into a CCL4 cirrhotic experimental model." | 1.48 | Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study. ( Atta, S; Demerdash, Z; El Baz, H; Hammam, O; Hassan, S; Kamel, M; Khalil, H; Meshaal, S; Raafat, I; Salah, F, 2018) |
| " Pharmacokinetic behaviors of silybin in rats were altered by co-administration of tangeretin, in terms of increased AUC and Cmax of silybin by comparing with that of silybin given alone." | 1.48 | Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. ( Feng, SL; Li, YZ; Liu, CX; Liu, L; Liu, ZQ; Xie, Y; Yuan, ZW; Zhou, H, 2018) |
| "The effect of stevia on liver cirrhosis has not been previously investigated." | 1.48 | Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. ( Buendia-Montaño, LD; Camacho, J; Casas-Grajales, S; Galindo-Gómez, S; Hernández-Aquino, E; Muriel, P; Ramos-Tovar, E; Tsutsumi, V, 2018) |
| "Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production." | 1.48 | Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes. ( Han, X; Kuang, Y; Wang, Y; Xu, M; Yang, Q; Zhao, Y, 2018) |
| "Ellagic acid (EA) is a strong antioxidant matter having protecting effect particularly on the liver." | 1.48 | Ellagic acid impedes carbontetrachloride-induced liver damage in rats through suppression of NF-kB, Bcl-2 and regulating Nrf-2 and caspase pathway. ( Aslan, A; Erman, O; Gok, O; Kuloglu, T, 2018) |
| "Maltol pretreatment groups did not show significant cell nuclear condensation and fragmentation, indicating that maltol inhibited CCl₄-induced cell apoptosis." | 1.48 | The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response. ( He, YF; Hou, JG; Jiang, S; Li, W; Liu, W; Ren, S; Wang, YP; Wang, Z; Zhou, YD, 2018) |
| "Sesamol is a phenolic component of sesame seed oil, which has been established as an antioxidant and also possesses potential for hepatoprotection." | 1.43 | Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats. ( Kakkar, V; Kaur, IP; Khullar, N; Singh, N, 2016) |
| " The LD50 value at 24 h was approximately 5950 mg/kg." | 1.43 | Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. ( El-Hadary, AE; Ramadan Hassanien, MF, 2016) |
| "Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, and inducible nitric oxide synthase mRNA levels." | 1.43 | Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. ( Bak, J; Cheong, KO; Chung, HY; Je, NK; Kim, KW; Lee, C; Moon, JO; Shin, DS; Yoon, S, 2016) |
| "In the present study, a formulation system consisting of cholesterol and phosphatidyl choline was used to prepare an effective chlorogenic acid-loaded liposome (CAL) with an improved oral bioavailability and an increased antioxidant activity." | 1.43 | Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. ( Feng, Y; Firempong, CK; Omari-Siaw, E; Pu, Z; Sun, C; Wan, J; Xu, X; Xu, Y; Yu, J; Yuan, Y; Zhu, Y, 2016) |
| "Carbon tetrachloride (CCl4 ) was used to induce acute and chronic liver injury in TWEAK KO mice." | 1.43 | Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation. ( Adams, DH; Afford, SC; Amatucci, A; Burkly, LC; Hübscher, S; Humphreys, E; Munir, M; Resheq, Y; Reynolds, G; Shepherd, EL; Weston, CJ; Wilhelm, A, 2016) |
| "Oleanolic acid (OA) is a well-known pentacyclic triterpenoid compound, which has been used as a dietary supplement and is supplied as an over-the-counter drug for the treatment of human liver diseases." | 1.43 | Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4. ( Jiang, T; Li, G; Peng, W; Sun, W; Yu, R; Yu, Z, 2016) |
| "Ritonavir is an antiretroviral drug to treat HIV AIDS and inhibits cytochrome P450 3A4." | 1.43 | Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function. ( Goud, T; Maddi, S; Nayakanti, D; Thatipamula, RP, 2016) |
| "Carbon tetrachloride (CCl4) is a liver toxicant, and CCl4-induced liver injury in mouse is a classical animal model of chemical liver injury." | 1.43 | Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice. ( Chen, X; Cui, X; Ge, J; Liu, Z; Niu, L; Qi, Y; Wu, Q; Xie, D, 2016) |
| "Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in permanent liver damage." | 1.43 | Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. ( Harpavat, S; Kim, KH; Lee, JM; Moore, DD; Zhou, Y, 2016) |
| "The present in vivo study revealed that the long term usage of ZES was safe for organs in laboratory animals." | 1.43 | Pharmacological safety evaluation of a traditional herbal medicine "Zereshk-e-Saghir" and assessment of its hepatoprotective effects on carbon tetrachloride induced hepatic damage in rats. ( Mandegary, A; Nematollahi, MH; Pardakhty, A; Sarhadynejad, Z; Sattaie-Mokhtari, S; Sharififar, F, 2016) |
| "Quercetin (QT) is a natural flavonoid with various biological activities and pharmacological actions." | 1.43 | Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats. ( Chen, X; Gu, L; Hu, G; Jia, J; Liu, Z; Zhang, K; Zhang, M; Zhang, Y, 2016) |
| "Liver fibrosis is a consequence of chronic liver lesion, which can progress into liver cirrhosis even hepatocarcinoma." | 1.43 | Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis. ( Chen, QL; Dong, S; Hu, YY; Li, XY; Liu, P; Song, YN; Su, SB; Sun, Y; Wei, B, 2016) |
| " These findings were confirmed with the histopathological observations, where SFEE was capable of reversing the toxic effects of CCl4 on liver cells compared to that observed in CCl4-intoxicated animals." | 1.43 | Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats. ( Abouzied, MM; Eltahir, HM; Hamed, AN; Wahid, A, 2016) |
| "Here, we use experimental models of liver fibrosis to show that deficiency of the scavenger receptor, stabilin-1, exacerbates fibrosis and delays resolution during the recovery phase." | 1.43 | Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury. ( Adams, DH; Dawes, H; Elima, K; Gerke, H; Hübscher, SG; Jalkanen, S; Karikoski, M; Laurila, J; Ohlmeier, S; Patten, DA; Rantakari, P; Salmi, M; Shetty, S; Valtonen, J; Weston, CJ, 2016) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| "Liver fibrosis is a global health problem and previous studies have demonstrated that reactive oxygen species (ROS) play important roles in fibrogenesis." | 1.43 | Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. ( Gao, Y; Gu, J; Kong, X; Sun, X; Wen, Y; Xia, Q; Yu, C; Yu, Y, 2016) |
| " Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor therapeutic application." | 1.42 | Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial. ( Bothiraja, C; Channekar, PR; Chaudhari, PD; Galgatte, UC; Shaikh, KS; Thingale, AD, 2015) |
| "Carbon tetrachloride (CCl(4)) was administered to induce acute liver injury in wild-type or COX-1-deficient mice." | 1.42 | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. ( Fung, ML; Huang, H; Lau, KS; Liong, EC; Nanji, AA; On Tse, W; Pan, J; Tipoe, GL; Xiao, J; Xing, F, 2015) |
| "1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks." | 1.42 | Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol. ( Baiev, DS; Biryukova, MS; Ivanova, EP; Nepomnyashchikh, GI; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA, 2015) |
| "Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent form of human hepatic disease and feeding mice a high-fat, high-caloric (HFHC) diet is a standard model of NAFLD." | 1.42 | Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet. ( Anderson, K; Cheverud, J; Green, RM; Hall, RA; Jafari, N; Kenney-Hunt, J; Lammert, F; Pasricha, S, 2015) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "CCl4-induced liver fibrosis protects mice against lethal dose of APAP, Possibly by a mechanism involving inhibition of the cytoplasmic translocation of HMGB1." | 1.42 | [Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury]. ( Bai, L; Chen, Y; Duan, Z; Ren, F; Zhang, X; Zheng, S; Zu, K, 2015) |
| " The toxic rat group received CCl4, while the treatment group received CCl4+P." | 1.42 | Effects of Pistacia Atlantica Extract on Erythrocyte Membrane Rigidity, Oxidative Stress, and Hepatotoxicity Induced by CCl4 in Rats. ( Mirzaei, A; Tolooei, M, 2015) |
| "Sesamin was administered in two different dose (5 and 10 ml/kg bw) to evaluate the hepatoprotective activity." | 1.42 | Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat. ( Liu, L; Lv, D; Zhu, CQ, 2015) |
| "Givinostat treatment increased intracellular reactive oxygen species production, decreased mitochondrial membrane potential, and promoted mitochondrial permeability transition pore opening." | 1.42 | Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. ( Meng, WY; Shi, M; Wang, N; Wang, T; Wang, YG; Wei, J; Xu, L, 2015) |
| " Phyllanthin along with piperine (a nutraceutical bioenhancer) was formulated as a mixed micellar lipid formulation (MMLF) in the present study and investigated to resolve the low bioavailability and enhance hepatoprotective effects on oral administration." | 1.42 | Antioxidant and hepatoprotective effects of mixed micellar lipid formulation of phyllanthin and piperine in carbon tetrachloride-induced liver injury in rodents. ( Mishra, SH; Nagar, PA; Rajpara, A; Sethiya, NK; Shah, P, 2015) |
| "Phyllanthin was found to effectively bind to serine (Ser) 280 at the active site of ALK5 by forming hydrogen bonds." | 1.42 | Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice. ( Jyothilakshmi, V; Krithika, R; Prashantha, K; Verma, RJ, 2015) |
| "Prednisolone treatment prevents T/NKT cell hepatitis but exacerbates hepatotoxin-induced liver injury by inhibiting macrophage- and neutrophil-mediated phagocytic and hepatic regenerative functions." | 1.40 | Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice. ( Feng, D; Gao, B; Kwon, HJ; Park, O; Won, YS, 2014) |
| " Oral bioavailability and hepatoprotective effects of orally dosed CoQ10 samples were also evaluated in rats." | 1.40 | Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system. ( Hashimoto, N; Nakamura, T; Onoue, S; Terasawa, N; Yamada, S; Yuminoki, K, 2014) |
| "In the present study, liver fibrosis was induced in wild-type (WT), TLR7-deficient, and IFN-α/β receptor-1 (IFNAR1)-deficient mice and TLR7-mediated signaling was assessed in liver cells isolated from these mice." | 1.40 | Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. ( Kim, B; Kim, JW; Lim, CW; Park, S; Roh, YS; Seki, E, 2014) |
| "Methylene blue (MB) has recently been considered for new therapeutic applications." | 1.40 | Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA. ( Hwang, SJ; Kim, SG; Lee, CG; Wu, HM, 2014) |
| "Salvianolic acid A (Sal A) was considered to be the compound with highest activity in Salvia miltiorrhiza (danshen)." | 1.40 | Transformation of salvianolic acid B to salvianolic acid a in aqueous solution and the in vitro liver protective effect of the main products. ( Chen, Z; Kan, S; Li, J; Shao, L, 2014) |
| "Riboflavin was administered at 30 and 100mg/kg by oral gavage to test its protective effect on hepatic injury biochemically and histopathologically in the blood/liver and liver respectively." | 1.40 | Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. ( Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Imam, F; Iqbal, M; Nadeem, A, 2014) |
| "Bifendate or MnSODm was intragastrically administered per day for 7 days." | 1.40 | Hepatoprotective effects of Mimic of Manganese superoxide dismutase against carbon tetrachloride-induced hepatic injury. ( Li, HL; Wang, YH; Xu, XJ, 2014) |
| "The carbon tetrachloride (CCI4) was used to prepare the acute liver injury rat model." | 1.40 | [Protection and bidirectional effect of rhubarb anthraquinone and tannins for rats' liver]. ( Bai, ZF; Hao, QX; Li, Y; Ma, ZJ; Qin, LS; Wang, JB; Xiao, XH; Yan, D; Zeng, LN; Zhang, P; Zhang, YM; Zhao, HP; Zhao, KJ; Zhao, YL, 2014) |
| "The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders." | 1.40 | Effect of apitherapy formulations against carbon tetrachloride-induced toxicity in Wistar rats after three weeks of treatment. ( Andritoiu, CV; Andritoiu, V; Ochiuz, L; Popa, M, 2014) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances." | 1.40 | Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats. ( Guelfi, M; Maioli, MA; Medeiros, HC; Mingatto, FE; Moreira, PR; Pereira, FT, 2014) |
| "Cupressuflavone pretreatment markedly inhibited the CCl4-induced increase in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, creatinine, uric acid, urea, and malondialdehyde levels in a dose-dependent manner (p < 0." | 1.40 | Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. ( Abdel-Daim, MM; Al-Sayed, E, 2014) |
| " The inability of BSS to protect against gentamicin nephrotoxicity was likely due to the relatively low bioavailability of BSS in rat kidneys." | 1.40 | β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling. ( Chan, WM; Chen, JH; Ko, KM; Leong, PK; Leung, HY; Wong, HS, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Acute hepatic injury and liver fibrosis in mice were induced by CCl4." | 1.40 | Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis. ( Liu, CH; Liu, ZL; Shen, L; Tao, YY; Yan, XC; Zhou, T, 2014) |
| " officinalis is safe and possesses antihepatotoxic potential." | 1.39 | Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn. ( Ahmad, F; Tabassum, N, 2013) |
| " After oral administration of NOB/SD (2 mg NOB/kg) in rats, compared with crystalline NOB, improved pharmacokinetic behavior was observed with increases of bioavailability and hepatic delivery by ca." | 1.39 | Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects. ( Asakawa, T; Hashimoto, N; Hiza, A; Kan, T; Nakamura, T; Ogawa, K; Onoue, S; Tsukaguchi, Y; Uchida, A; Yamada, S; Yuminoki, K, 2013) |
| " At the studying of the bile formation and bile secretion functions in the conditions of the toxic tetrachlormethane lesion the hepatoprotective effect of the dosage form was confirmed, which was realized by the increasing of the speed of bile secretion and its volume." | 1.39 | [Studying of hepatoprotective properties of dry extract from apricot leaves on the model of liver lesion by tetrachloromethane]. ( Fira, LS; Likhatskiĭ, PG; Medvid', II; Pyla, VP; Shtroblia, AL; Vashkeba, EM, 2013) |
| " Histological examinations revealed that SP2 was more potent than SP1 in protecting the liver from toxic injury of CCl4 and preserving the hepatocyte ultrastructure." | 1.39 | Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4. ( Bayat, N; Çelik, A; Kepekçi, RA; Polat, S; Saygideger, SD, 2013) |
| "Extent of fibrosis was examined by Masson's stain and measuring hydroxyproline levels." | 1.39 | Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators. ( Abdel-Naim, AB; Algandaby, MM; Breikaa, RM; El-Demerdash, E, 2013) |
| " The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs (NSAIDs) and carbon tetrachloride (CCl4)." | 1.39 | Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis. ( Asif, HM; Jamil, A; Jamil, MS; Mahmood, Z; Roohi, M; Saeed, A; Usmanghani, K, 2013) |
| "The purpose of this study was to develop a novel silymarin-loaded solid nanoparticle system with enhanced oral bioavailability and an ability to provide excellent hepatic protection for poorly water-soluble drugs using Shirasu porous glass (SPG) membrane emulsification and a spray-drying technique." | 1.39 | Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation. ( Bae, ON; Choi, HG; Hwang, du H; Kim, DW; Kim, JO; Kim, YI; Shin, YJ; Yang, KY; Yong, CS; Yousaf, AM, 2013) |
| "Quercetin is a plant-based antioxidant traditionally used as a treatment for hepatic injury, but its poor solubility affects its bioavailability." | 1.39 | Protective effects of quercetin and quercetin-5',8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice. ( Cui, Y; Han, Y; Sun, Y; Yang, X; Zhao, Y, 2013) |
| " Liver function tests and histopathological evaluation were carried out at the end of dosing using standards kits." | 1.39 | Hepatoprotective effect of herbal drug on CCl(4) induced liver damage. ( Feroz, Z; Khan, RA, 2013) |
| "Fucoxanthin was immunohistochemically shown to increase heme oxygenase-1 expression in the cultured liver cells of Hc cells and TRL1215 cells." | 1.39 | The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity. ( Kaneko, M; Mori, M; Nagamine, T; Nakazato, K, 2013) |
| " It could be concluded that honey and KGE protect SD rats against the severe CCl(4)-induced hepatic and renal toxic effects." | 1.38 | Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats. ( Abdel-Wahhab, MA; Al-Gahazali, MA; El Denshary, ES; Hassan, NS; Mannaa, FA; Salem, HA, 2012) |
| "Carbon tetrachloride (CCl(4)) is a well-known model for inducing chemical hepatic injury in Swiss albino mice." | 1.38 | Protective effects of lycorine against carbon tetrachloride induced hepatotoxicity in Swiss albino mice. ( Ilavenil, S; Kaleeswaran, B; Ravikumar, S, 2012) |
| " However, DDB therapeutic effectiveness is restricted by its low oral bioavailability that arises from its poor solubility and dissolution." | 1.38 | Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation. ( Abdelbary, GA; Aburahma, MH, 2012) |
| " In conclusion, we discovered metabolite biomarkers belonging to three different metabolic pathways to check for liver toxicity with mass spectrometry from a metabolomics study that could be used to evaluate hepatotoxicity induced by drugs or other toxic compounds." | 1.38 | Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. ( Chung, BC; Jung, BH; Kumar, BS; Kwon, OS, 2012) |
| "Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process." | 1.38 | Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. ( Fiel, MI; Ge, X; Lu, Y; Mormone, E; Nieto, N, 2012) |
| "Carbon tetrachloride was used to induce acute liver injury in mice; cells or secreted proteins were administered by intrasplenic or intraperitoneal injection, respectively." | 1.38 | Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. ( Ahn, EK; Chenoweth, JG; Choi, TH; Heo, J; Hoeppner, DJ; Hong, SH; Kang, GY; Kim, JH; Kim, SE; Kim, SK; Kim, Y; Kwon, H; Lee, JH; Lim, HJ; McKay, RD; Park, HS; Song, KW; Tesar, PJ; Woo, DH; You, HJ, 2012) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver injury in TP knockout (TP(-/-)) mice and wild-type (WT) mice." | 1.38 | Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. ( Ae, T; Hosono, K; Ito, Y; Koizumi, W; Majima, M; Minamino, T; Narumiya, S; Ohkubo, H; Sakagami, H; Sato, T; Shibuya, A; Suzuki, T, 2012) |
| " The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values." | 1.38 | Hepatoprotective effect of Filipendula hexapetala Gilib. (Rosaceae) in carbon tetrachloride-induced hepatotoxicity in rats. ( Cebović, T; Maksimović, Z, 2012) |
| "Oleuropein is a non-toxic secoiridoid found in the leaves and fruits of olive (Olea europaea L." | 1.38 | Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. ( Domitrović, R; Jakovac, H; Marchesi, VV; Rahelić, D; Romić, Ž; Šain, I, 2012) |
| " The plant proved to be safe for human use because it did not induce any signs of toxicity or mortality in mice when administered orally at doses up to 5000 mg kg(-1)." | 1.38 | Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats. ( Alqasoumi, SI; Awaad, AS; El-Gindi, OD; El-Sayed, DF; Soliman, GA, 2012) |
| "Phenacetin metabolism was impaired more severely in 6 rats that died than in 21 living rats (P < 0." | 1.38 | Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury. ( Cai, M; He, P; Li, X; Liu, Z; Qu, Z; Wang, X; Xiao, J; Zhou, M, 2012) |
| " Group II was toxic control and was given a single dose of CCl(4) on 8th days." | 1.38 | Lygodium flexuosum extract down regulates the expression of proinflammatory cytokines in CCl4-induced hepatotoxicity. ( Asha, VV; Wills, PJ, 2012) |
| "Carbon tetrachloride (CCl(4)) has been used extensively to study xenobiotic-induced oxidative liver injury." | 1.38 | Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. ( Deng, X; Jia, M; Jiang, R; Jing, Y; Li, L; Wan, J; Wu, K; Zhang, L, 2012) |
| " The toxic chemicals tested were carbon tetrachloride, cisplatin (a popular anti-tumor agent), and a widely used herbicide, paraquat." | 1.38 | Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat. ( Ishida, I; Isoda, K; Nagai, Y; Shimizu, Y; Tezuka, E; Tezuka, M; Yufu, T, 2012) |
| "Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity." | 1.38 | CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. ( Khan, MR; Khan, RA; Sahreen, S, 2012) |
| "Metabolomics has been frequently used in pharmacodynamic studies, especially those on traditional Chinese medicine (TCM)." | 1.38 | Radix Paeoniae Rubra and Radix Paeoniae Alba Attenuate CCl4-induced acute liver injury: an ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) based metabolomic approach for the pharmacodynamic study of Traditional Chinese Medicines (TCMs) ( Shi, YH; Teng, ZQ; Wang, R; Xiong, AZ; Yang, L; Yang, QW, 2012) |
| "Gold particles have been used in complementary medicine for decades, and many beneficial effects have been reported." | 1.38 | Effects of nanogold on the alleviation of carbon tetrachloride-induced hepatic injury in rats. ( Chen, YJ; Chen, YP; Chuu, JJ; Dai, ZH; Lee, KY; Lee, SL; Liu, PC, 2012) |
| " In conclusion, the nanoemulsification method may be applied for poor water-soluble ethanolic herbal extracts to reduce the dosage and time." | 1.38 | Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats. ( Deepa, V; Goparaju, A; Murthy, PB; Reddy, PN; Sridhar, R, 2012) |
| "Berberine was administered as a single dose at 5 and 10mg/kg intraperitoneally (i." | 1.37 | Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. ( Blagojević, G; Domitrović, R; Jakovac, H, 2011) |
| "Carbon tetrachloride (CCl(4)) is a common hepatotoxin used in experimental models to elicit liver injury." | 1.37 | Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. ( Fan, ST; Jiang, PP; Jor, IW; Lee, CY; Ling, WL; Man, K; Sit, WH; Tam, KT; Wan, JM; Wong, LL, 2011) |
| "Carbon tetrachloride treatment alone caused a decrease in total cytochrome P450 content, an increase in CYP2E1 and CYP3A1 messenger RNA (mRNA) levels, and an increase in CYP2E1 and a decrease in CYP3A1 enzymatic activity." | 1.37 | Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir. ( Hong, Z; Hu, J; Li, T; Lin, J; Zhao, J; Zhou, J, 2011) |
| " Experiment lasted 11 days and dosing was via oral route." | 1.37 | Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats. ( Adesanoye, OA; Bamidele, TO; Ekor, M; Kale, OE; Odewabi, AO; Oritogun, KS, 2011) |
| "Cornuside treatment inhibited the formation of liver nitrite, and reduced the overexpression of iNOS and COX-2 proteins, but restored the liver CYP2E1 content as compared with the CCl₄-treated rats." | 1.37 | Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury. ( Choi, YH; Jin, GY; Li, GZ; Song, SZ; Yan, GH, 2011) |
| "Oxidative stress is related to the liver fibrosis, anticipating the hepatic stellate cells' (HSC) activation." | 1.37 | Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis. ( Catoi, C; Clichici, S; Daicoviciu, D; Decea, N; Filip, A; Gherman, C; Login, C; Mocan, T; Moldovan, R; Muresan, A; Nagy, A, 2011) |
| "Esculetin (ESC) is a coumarin that is present in several plants such as Fraxinus rhynchophylla and Artemisia capillaris." | 1.37 | Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. ( Chang, WT; Chiu, CS; Huang, CY; Huang, TH; Liao, JC; Peng, WH; Tien, YC, 2011) |
| "Pretreatment with vanillin prior the administration of CCl(4) significantly prevented the decrease of protein synthesis and the increase in plasma alanine (ALT) and aspartate (AST) aminotransferases." | 1.37 | Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats. ( Boudawara, T; Chtourou, Y; Fetoui, H; Garoui, el M; Makni, M; Zeghal, N, 2011) |
| " However, some herbs, such as rhubarb, have been documented as having both therapeutic and toxic effects on the liver, leading to the complex problem of distinguishing the benefits from the risks of using this herb." | 1.37 | Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. ( Fang, F; Jin, C; Kong, WJ; Liu, DJ; Wang, HJ; Wang, JB; Xiao, XH; Zhang, L; Zhao, HP; Zhao, YL, 2011) |
| "The methanol extract was purified by repeated column chromatography, resulting in the identification of five metabolites whose hepatoprotective effects were evaluated by measuring aspartate transaminase, alanine transaminase, alkaline phosphatase, glutamate, total bilirubin level, lactate dehydrogenase, total serum protein, and lipid peroxidation (thiobarbituric acid reactive substances assay) in CCl(4)-induced hepatic injury in mice." | 1.37 | Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice. ( Anaya Sosa, I; Hoyo Vadillo, C; Perez Gutierrez, RM; Victoria, TC, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " These results suggest that the extract as well as the constituents could protect the hepatocytes from CCl(4)-induced liver damage perhaps, by their anti-oxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl(4)." | 1.36 | In vitro antioxidant and in vivo prophylactic effects of two gamma-lactones isolated from Grewia tiliaefolia against hepatotoxicity in carbon tetrachloride intoxicated rats. ( Dandin, CJ; Khadeer Ahamed, MB; Krishna, V, 2010) |
| "The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats." | 1.36 | Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats. ( Abdel Salam, OM; Shafee, N; Sleem, AA, 2010) |
| "Baicalein treatment (20, 40, or 80 mg/kg for 10 weeks) dose-dependently decreased levels of these markers." | 1.36 | Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. ( Che, QM; Pu, XP; Sun, H; Zhao, X, 2010) |
| "Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective." | 1.36 | Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010) |
| " The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days." | 1.36 | Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity. ( Anuradha, CV; Pooranaperundevi, M; Sumiyabanu, MS; Sundarapandiyan, R; Viswanathan, P, 2010) |
| " Although andrographolide has antihepatotoxic activity, its bioavailability from A." | 1.36 | Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome. ( Maiti, K; Mukherjee, K; Mukherjee, PK; Murugan, V; Saha, BP, 2010) |
| "Glycogen was decreased by CCl(4), while celecoxib partially prevented and reversed this effect." | 1.36 | Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat. ( Castro-Sánchez, L; Chávez, E; Moreno, MG; Muriel, P; Salazar, EP; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2010) |
| "All mice developed liver fibrosis." | 1.36 | Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. ( Brenner, DA; Gu, G; Iwaisako, K; Kisseleva, T; Osterreicher, CH; Scholten, A; Scholten, D, 2010) |
| "Marimastat-treated animals demonstrated significantly attenuated liver injury and inflammation but a 25% increase in collagen deposition." | 1.36 | Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. ( de Meijer, VE; Le, HD; Meisel, JA; Nosé, V; Popov, Y; Puder, M; Schuppan, D; Sverdlov, DY, 2010) |
| "Although pharmacokinetic alternations by hepatic injury have been extensively studied, little is known about the potential influence of hepatoprotective agent's treatment." | 1.36 | Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers. ( Dai, C; Hao, H; Kang, A; Li, J; Liang, Y; Sun, S; Wang, G; Xie, L; Xie, T; Xie, Y; Zheng, X, 2010) |
| "Hydroxyproline, which is an indicator of fibrosis in liver tissue, was high in the ethanol-treated control group." | 1.36 | Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. ( Firdous, AP; Kuttan, R; Preethi, KC; Sindhu, ER, 2010) |
| "Embelin treatment significantly prevented NDEA or CCl4 induced increase in biochemical marker enzymes: glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, glutathione-S-transferase, lipid peroxidase as well as hypoproteinemia, hypoalbuminuria and glutathione depletion." | 1.36 | Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver. ( Bhagwat, S; Gupta, S; Khade, B; Maru, G; Poojari, R, 2010) |
| "Treatment with trazodone or nefazodone caused a dose-dependent decrease in serum nitric oxide levels compared with the CCl(4) control group." | 1.36 | Effect of trazodone and nefazodone on hepatic injury induced by carbon tetrachloride. ( Abdel Salam, OM; Shafee, N; Sleem, AA, 2010) |
| "Fulminant hepatitis or acute liver failure (ALF), initiated by viral infection or hepatic toxin, is a devastating medical complication without effective therapeutic treatment." | 1.35 | Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. ( Han, YP; Yan, C; Zhou, L, 2008) |
| "Several in vitro studies have demonstrated the ability of pure trans-resveratrol (t-Res) to act as an anti-oxidant, but the scientific literature is lacking in in vivo studies dealing with dietary t-Res bioavailability in oxidative stress models." | 1.35 | Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. ( Caporaso, N; Fogliano, V; Milani, S; Morisco, F; Ottanelli, B; Vitaglione, P, 2009) |
| "Carbon tetrachloride (CCl(4)) is a well-known model compound for inducing chemical hepatic injury." | 1.35 | An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine. ( Lin, Y; Liu, C; Si, D; Zhang, Z, 2009) |
| "Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always associated with inflammation that contributes to fibrogenesis." | 1.35 | Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. ( Gao, B; Gershwin, ME; Jeong, WI; Lian, ZX; Park, O; Wang, H; Wang, L, 2009) |
| " Histopathological results also suggested the hepatoprotective activity of ononitol monohydrate with no adverse effect." | 1.35 | Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats. ( Agastian, P; Dhanasekaran, M; Ignacimuthu, S, 2009) |
| "Toxic hepatitis was induced by a single carbon tetrachloride injection in Gas6 deficient (Gas6(-/-)) mice and liver recovery was compared with wild-type animals." | 1.35 | Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. ( Brouillet, A; Chobert, MN; Deveaux, V; Lafdil, F; Laperche, Y; Mavier, P; Nakano, T; Zafrani, ES, 2009) |
| "Dicofol pretreatment at 25mg/kg increased CCl4-induced serum alanine aminotransferase activity by 4." | 1.35 | Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. ( Chan, PK; Chan, WH; Chou, CP; Liao, JW; Ueng, TH; Wei, CF, 2009) |
| " In the time course study, rats were dosed at 0." | 1.35 | Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride-induced hepatic injury in the Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2009) |
| "The progression of toxic hepatitis is accompanied by the activation of oxidative processes in the liver associated with an enhancement of the mitochondrial respiratory chain activity and superoxide anion production (O(2)(*-))." | 1.35 | Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis. ( Arkadyeva, A; Emelyanova, L; Morozov, V; Sakuta, G; Shiryaeva, A, 2009) |
| "Carbon tetrachloride (CCl4) is a xenobiotic used extensively to induce oxidative stress and is one of the most widely used hepatic toxins for experimental induction of liver fibrosis in the laboratory." | 1.35 | Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. ( Ho, PC; Hsieh, YS; Huang, CY; Liu, JY; Liu, YC; Shyu, JC; Tsai, CC; Tsai, JH; Wu, TT, 2008) |
| " In conclusion, our results indicate that, although sage tea did not have toxic effects of its own, herb-drug interactions are possible and may affect the efficacy and safety of concurrent medical therapy with drugs that are metabolized by phase I enzymes." | 1.34 | Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice. ( Fernandes-Ferreira, M; Lima, CF; Pereira-Wilson, C, 2007) |
| "Co-treatment with salvianolic acid A (20 mg/kg, intraperitoneally), a water-soluble extract from a Chinese traditional drug, Radix Salvia miltiorrhiza, significantly decreased CCl(4)-induced hepatotoxicity." | 1.34 | Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. ( Liu, Y; Ren, F; Tan, YF; Wen, T; Wu, H; Wu, ZM, 2007) |
| "Bakuchiol treatment stimulated the activation of extracellular signal-regulated kinase 1/2 (ERK), c-Jun NH2-terminal protein kinase (JNK), and p38 mitogen-activated protein kinases (MAPK) in vitro." | 1.34 | Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. ( Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ, 2007) |
| "We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium in 66 rabbits randomly treated with 0." | 1.34 | The pharmacodynamics of mivacurium in the rabbit with carbon tetrachloride-induced liver disease. ( Cheong, MA; Kim, KS; Lee, GS, 2007) |
| "Pretreatment with kahweol and cafestol prior to the administration of CCl(4) significantly prevented the increase in the serum levels of hepatic enzyme markers (alanine aminotransferase and aspartate aminotransferase) and reduced oxidative stress, such as reduced glutathione content and lipid peroxidation, in the liver in a dose-dependent manner." | 1.34 | Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. ( Choi, JH; Jeong, HG; Lee, KJ, 2007) |
| "Genistein has anti-inflammatory and antinecrotic effects on experimental liver damage caused by CCl4." | 1.34 | Protective role of genistein in acute liver damage induced by carbon tetrachloride. ( Akdemir, F; Bahcecioglu, IH; Dagli, AF; Kuzu, N; Metin, K; Orhan, C; Ozercan, IH; Sahin, K; Yalniz, M, 2007) |
| "Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities." | 1.34 | Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. ( Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK, 2007) |
| " Treatment of the toxic hepatitis with heptral increased the level of cytochrome P450, cytochrome b5, glutation activity of glutationetranspherase glutathione and reduced content of homocysteine." | 1.34 | [Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]. ( Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN, 2007) |
| "Oleanolic acid is a naturally derived triterpene used clinically in the treatment of hepatitis in China, but its poor solubility often leads to poor bioavailability." | 1.33 | Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect. ( Chen, Y; Liu, J; Xu, H; Yang, X; Zhao, X, 2005) |
| " The rats of model group and treatment group were given small dosage of CCL4 combined with a fat-rich diet, and those of control group were given normal diet." | 1.33 | Effect of Sinai san decoction on the development of non-alcoholic steatohepatitis in rats. ( Sun, LJ; Zhang, DB; Zhang, Q; Zhao, Y, 2005) |
| " PGE2 administration started 3 h after the additional dosing of CCl4 and PGE2 effect on hepatorenal function was examined on days 1, 2, 3, and 7." | 1.33 | PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. ( Armendáriz-Borunda, J; Covarrubias, A; Cruz, C; Estanes, A; Islas-Carbajal, MC; Panduro, A; Pedraza-Chaverrí, J; Rincón-Sánchez, AR; Rivas-Estilla, AM, 2005) |
| "Gabexate mesilate treatment significantly decreased the elevation of serum transaminase levels and improved liver histology 24 h after the administration of CCl4 (0." | 1.33 | Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats. ( Goto, T; Kataoka, E; Lin, JG; Mikami, K; Miura, K; Ohshima, S; Segawa, D; Shibuya, T; Watanabe, D; Watanabe, S; Yoneyama, K, 2005) |
| "The p8 protein is a transcription factor that regulates the expression of genes involved in cell defense against the adverse effects of stress." | 1.33 | Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. ( Arnaud, C; Dagorn, JC; Garcia, S; Iovanna, JL; Malicet, C; Rocchi, P; Taïeb, D; Vasseur, S, 2005) |
| "Bakuchiol treatment (25 and 50 mg/kg, p." | 1.33 | Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo. ( Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ, 2005) |
| "Bicyclol is a novel synthetic drug for the treatment of chronic viral hepatitis in China." | 1.33 | Mechanism of protective action of bicyclol against CCl-induced liver injury in mice. ( Li, Y; Liu, GT; Wei, HL; Xu, JY; Yu, LH; Zhang, H, 2005) |
| "Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing." | 1.33 | Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice. ( Hennig, GE; Manautou, JE; Silva, VM, 2006) |
| " It has been shown to metabolize 4-hydroxynonenal (4-HNE) with high catalytic efficiency through its conjugation to glutathione (GSH) and has been suggested to be a major component of cellular defense against toxic electrophiles such as 4-HNE generated during LPO." | 1.33 | The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice. ( Awasthi, YC; Boor, PJ; Ceci, JD; Dwivedi, S; Sharma, A; Sharma, R; Zimniak, P, 2006) |
| " Aiming at improving its poor bioavailability from oral products, silymarin hybrid liposomes are introduced in this work for buccal administration after investigating their stability and in vivo hepatoprotective efficiency." | 1.33 | Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance. ( Afifi, NN; El-Samaligy, MS; Mahmoud, EA, 2006) |
| "Carbon tetrachloride (CCl(4)) treatment of rats causes lipid peroxidation of cell membranes and produces massive hepatic injury." | 1.33 | Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. ( Akagi, R; Katayama, H; Kawakami, T; Morita, K; Nakahira, K; Sassa, S; Shimizu, H; Takahashi, T; Takeuchi, M; Yokoyama, M, 2006) |
| " The results showed that the inhibitory effect of DMF and its crude triterpenoids on lipid peroxidation occurred in a dose-response manner in an AAPH/linoleic acid system." | 1.32 | Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. ( Song, TY; Yen, GC, 2003) |
| "Tectorigenin was isolated from the flowers of pueria thunbergiana as an inhibitor of beta-glucuronidase, and serum ALT, AST and biological parameters as markers for its hepatoprotective activity were measured on CCl4-induced liver injury in mice." | 1.32 | Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury. ( Bae, EA; Choo, MK; Kim, DH; Lee, HW, 2003) |
| "We have developed a type 2 diabetes rat model that closely resembles the diabetic patients and takes only 24 days to develop robust diabetes." | 1.32 | Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. ( Dnyanmote, AV; Latendresse, JR; Limaye, PB; Mehendale, HM; Sawant, SP; Shankar, K, 2004) |
| "Acanthoic acid pretreatment (100 mg/kg per day for four consecutive days, p." | 1.32 | Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo. ( Kim, YH; Lee, JJ; Park, EJ; Sohn, DH; Zhao, YZ, 2004) |
| "Liver cirrhosis was produced by an 8-week intraperitoneal injection of CCl(4) in male Sprague-Dawley rats." | 1.32 | Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats. ( Goto, T; Kataoka, E; Lin, JG; Mikami, K; Miura, K; Odashima, M; Ohshima, S; Otaka, M; Segawa, D; Watanabe, D; Watanabe, S; Yoneyama, K, 2004) |
| "Portal hypertension was successfully induced in 15 dogs." | 1.32 | [Morphology of portal hypertension at the early stage of liver damage induced by CCl4: an experimental study with dogs]. ( Wei, YW; Xue, DB; Zhang, RP; Zhang, WH, 2004) |
| "Carbon tetrachloride (CCl(4)) is a known hepatotoxic compound working through the generation of reactive free radicals." | 1.32 | Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. ( Bhattacharya, S; Das, RK; Das, S, 2004) |
| "Liver-necrosis was observed in CCl(4)-injected rats without pretreatment of flaxseed extract." | 1.31 | Protective effect of a lignan-containing flaxseed extract against CCl(4)-induced hepatic injury. ( Arikawa, J; Endoh, D; Hayashi, M; Kon, Y; Okui, T; Ozawa, S; Yamato, O, 2002) |
| "Acute toxic hepatitis in male Wistar rats was produced by single injection of 40% CCl(4) (0." | 1.31 | Liver resistance to CCl(4)-induced injury after stimulation of macrophages with various preparations. ( Kutina, SN; Zubakhin, AA, 2000) |
| "Pretreatment with gadolinium chloride, a selective blocker of Kupffer cells, considerably potentiated damage to hepatocytes leading to generalization of this process, delayed inflammatory infiltration, and inhibited reparative processes." | 1.31 | Liver resistance to toxic effects of CCl(4) under conditions of gadolinium chloride depression of Kupffer cells. ( Cyrendorzhiev, DD; Kutina, SN; Zubakhin, AA, 2000) |
| " Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use." | 1.31 | The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity. ( Blazka, ME; Bruccoleri, A; Gallucci, RM; Luster, MI; Matheson, JM; Simeonova, PP; Yucesoy, B, 2000) |
| "Metallothionein and zinc have been implicated in cellular defense against a number of cytotoxic agents." | 1.31 | Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice. ( Cousins, RJ; Davis, SR; Samuelson, DA, 2001) |
| "(Cucurbitaceae) were tested for their hepatoprotective activity against CCl(4) induced hepatotoxicity in albino rats." | 1.31 | Hepatoprotective activity of Luffa echinata fruits. ( Ahmed, B; Alam, T; Khan, SA, 2001) |
| "Treatment with ursolic acid also significantly reversed the decreased superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase activities and glutathione levels in the liver, as the concentration of reduced glutathione was increased and the content of oxidized glutathione decreased in ursolic acid treated groups." | 1.31 | Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. ( Benedi, J; de las Heras, B; Martin-Aragón, S; Sanchez-Reus, MI, 2001) |
| "Carbon tetrachloride was injected intraperitoneally into mice deficient in plasminogen, fibrinogen, or both, and to normal littermates, followed by determination of the phenotype of HSCs, matrix deposition, and apoptosis." | 1.31 | Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury. ( Bezerra, JA; Degen, JL; Kelley-Loughnane, N; Melin-Aldana, H; Ng, VL; Sabla, GE, 2001) |
| " We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1)." | 1.31 | Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. ( Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y, 2002) |
| "Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS)." | 1.30 | Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. ( Basnet, P; Hase, K; Kadota, S; Kasimu, R; Namba, T, 1997) |
| " The results of these studies demonstrated that CS-mediated protection is not selective for a particular species, organ system or toxic chemical." | 1.30 | Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. ( Fariss, MW; Lippman, HR; Mumaw, VR; Ray, SD, 1997) |
| " No toxicologically significant differences in pharmacokinetic parameters as a function of Emulphor concentration were found." | 1.30 | Effect of Emulphor, an emulsifier, on the pharmacokinetics and hepatotoxicity of oral carbon tetrachloride in the rat. ( Bruckner, JV; Sanzgiri, UY, 1997) |
| "Astilbine was capable to restore lipoperoxides and tissue prostanoids to basal values." | 1.30 | Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: effect of astilbin. ( Bioque, G; Closa, D; Gelpí, E; Hotter, G; León, OS; Rósello-Catafau, J; Torres, M, 1997) |
| " Pretreating mice with Sch A at a daily oral dose of 1 mmol/kg for 3 days did not protect against CCl4 hepatotoxicity, whereas pretreatment with Sch B or Sch C at the same dosage regimen produced almost complete protection." | 1.30 | Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice. ( Che, CT; Ip, SP; Ko, KM; Ma, CY, 1997) |
| "Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90)." | 1.30 | Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction. ( Roberts, SM; Salminen, WF; Voellmy, R, 1997) |
| "The aim of this work was to determine if the inhibition or stimulation of NO synthesis modulates liver damage induced by the chronic administration of CCl4." | 1.30 | Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride. ( Muriel, P, 1998) |
| "Carbon tetrachloride-injected rats were given liquid diets with and without betaine for 7 d." | 1.30 | Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. ( Barak, AJ; Beckenhauer, HC; Junnila, M; Rahko, T, 1998) |
| "Potent antidotal effects on mushroom poisoning in beagle dogs ingested with aqueous extract of Amanita virosa was observed; beagle dogs completely survived, even when AU administration was withheld for half an hour after mushroom poisoning." | 1.30 | Liver-protective activities of aucubin derived from traditional oriental medicine. ( Chang, IM, 1998) |
| "Pretreatment with oleanolic acid prior to the administration of carbon tetrachloride significantly prevented the increase in serum alanine aminotransferase and lactate dehydrogenase activity and liver lipid peroxidation in a dose-dependent manner." | 1.30 | Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury. ( Jeong, HG, 1999) |
| " Rats or mice were dosed with VA (retinol) at 75 mg/kg/day, po, for 7 days." | 1.29 | Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents. ( Hill, DA; Hooser, SB; Mobley, SA; Rosengren, RJ; Sipes, IG, 1994) |
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 1.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| "Colchicine was administered 2 h prior to CCl4 or corn oil injection." | 1.29 | Effect of antimitotic agent colchicine on carbon tetrachloride toxicity. ( Mehendale, HM; Rao, VC, 1993) |
| "CCl4 produced hepatocellular necrosis." | 1.29 | Effects of alcohol, carbon tetrachloride, and choline deficiency on iron metabolism in the rat. ( Batey, RG; Johnston, R, 1993) |
| " The pharmacokinetic analysis of these data showed that the decreased total plasma clearance of ICG in GAL and CCl4 rats results from both lowered influx across the sinusoidal plasma membrane of hepatocytes and the decreased hepatic plasma flow." | 1.29 | Pharmacokinetics of indocyanine green in rats with experimentally induced hepatic diseases. ( Kimura, T; Kurosaki, Y; Nakayama, S; Nakayama, T; Yamao, T, 1993) |
| " In the initial 3-week dose-response study, as the daily dose of VA increased so did the degree of potentiation of CCl4 hepatotoxicity." | 1.29 | Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury. ( Earnest, DL; elSisi, AE; Hall, P; Sim, WL; Sipes, IG, 1993) |
| " From these experiments, we conclude that retinol pretreatment decreases the severity of 2-nitronaphthalene and paraquat-induced pulmonary toxicity, apparently by inhibiting the inflammatory responses associated with the progression of toxic injury." | 1.29 | Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat. ( Sauer, JM; Sipes, IG, 1995) |
| "The present study was designed to evaluate the effects of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (PMC) in combination with garlic oil against chemical-induced hepatic injury in rats and mice." | 1.29 | Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice. ( Chung, HC; Hong, SY; Jung, KH; Kim, SG; Nam, SY, 1995) |
| " Light microscopic examination of sections of the liver taken 5 weeks after dosing of CCl4 showed hydropic degeneration of hepatocytes around the central veins and lipid vacuolation in mid-zonal and some periportal hepatocytes." | 1.29 | Abnormal expressions of hepatocellular proteins and extracellular matrix in CCL4-induced liver injury in rats. ( Chen, L; Yang, X; Zhong, X; Zhou, J, 1996) |
| " Animals pretreated with this hepatotoxic agent showed a significant prolongation in the half-life of diazepam in plasma that is due more to an increase in volume of distribution rather than to a decrease in clearance." | 1.28 | Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury. ( Díaz-García, JM; Fos-Galve, D; Oliver-Botana, J, 1992) |
| " The peak elevation in urinary taurine occurred within the first 48 h after dosing but there was still significant taurinuria 72 and 96 h after the intermediate dose (1 ml." | 1.28 | Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride-treated rats. ( Scales, MD; Timbrell, JA; Turton, JA; Waterfield, CJ, 1991) |
| " Impairment of xenobiotic biotransformation was confirmed by elevated pentobarbital sleeping time in animals under the same CCl4 dosing regimen." | 1.28 | Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat. ( Crofton, KM; Llorens, J, 1991) |
| " In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion." | 1.28 | Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990) |
| " Liver samples were collected from these mice 5 days before (by biopsy) and 18 days after dosing with CCl4 (1 ml/kg, i." | 1.28 | Evidence of clonal proliferation of hepatocytes after carbon-tetrachloride-induced hepatic injury in PGK-1 mosaic mice. ( Kamiyama, S; Koizumi, A; Tsukada, M; Wada, Y, 1990) |
| "Hyperbilirubinemia was observed early in ponies of the ligated group; most of the bilirubin was of the conjugated type." | 1.28 | Serum lipid and lipoprotein changes in ponies with experimentally induced liver disease. ( Bauer, JE; Campbell, M; McMurphy, R; Meyer, DJ, 1990) |
| "142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals." | 1.28 | In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity. ( Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D, 1989) |
| "Kopsinine is an indole alkaloid." | 1.28 | [Protective action of kopsinine against experimental liver injuries in mice]. ( Huang, WY; Liu, GT, 1989) |
| " This dosing regimen also resulted in a significant decrease in thymus weights; however, there were no significant effects on liver, kidney, lung, or body weights." | 1.28 | Suppression of humoral and cell-mediated immune responses by carbon tetrachloride. ( Holsapple, MP; Jordan, SD; Kaminski, NE, 1989) |
| "Medroxyprogesterone acetate (MPA) has an inducing effect on the hepatic drug-metabolizing enzyme system in the rat." | 1.27 | Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury. ( Kärki, NT; Saarni, HU; Sotaniemi, EA; Stengård, J, 1983) |
| "Carbon tetrachloride was injected s." | 1.27 | Strain differences in mice in carbon tetrachloride-induced liver injury. ( Bhathal, PS; Mackay, IR; Rose, NR; Whittingham, S, 1983) |
| " After dosing 100 microliter CCl4/kg, the response of OCT activity was 10- and 20-times higher than that of GOT and GPT, respectively." | 1.27 | Comparative study on the sensitivity of several serum enzymes in detecting hepatic damage in rats. ( Baumann, M; Berauer, M, 1985) |
| "Post-treatment with methoxsalen must be given early and is only partially effective in mice." | 1.27 | The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. ( Amouyal, G; Carrion-Pavlov, Y; Degott, C; Descatoire, V; Geneve, J; Labbe, G; Larrey, D; Letteron, P; Pessayre, D; Tinel, M, 1987) |
| "Administration of acetone to rats in amounts larger than or equal to a minimal effective dosage (MED) is known to potentiate the severity of the liver damage produced by CCl4 alone." | 1.27 | Assessment of the minimal effective dose of acetone for potentiation of the hepatotoxicity induced by trichloroethylene-carbon tetrachloride mixtures. ( Brodeur, J; Charbonneau, M; Greselin, E; Perreault, F; Plaa, GL, 1988) |
| "Sodium propionate (3 mmol/kg) was injected IV into 6 healthy sheep before and after they were given carbon tetrachloride (20% CCl4 in mineral oil; 0." | 1.27 | Propionate loading test for liver function during experimental liver necrosis in sheep. ( Bruss, ML; Gröhn, Y; Lindberg, LA, 1985) |
| "Pretreatment with phenobarbital (0." | 1.27 | Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats. ( Loeser, W; Siegers, CP, 1985) |
| "Treatment with cycloheximide and a hepatotoxic dose of CCl4 (well tolerated in normal animals) is acutely toxic in animals bearing the Ehrlich ascites tumour." | 1.26 | The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice. ( Parry, EW, 1980) |
| " The blood concentrations of 2-butanol, 3-hydroxy-2-butanone and 2,3-butanediol detected 4 h after dosing were 3." | 1.26 | Potentiation of CCl4 hepatotoxicity in rats by a metabolite of 2-butanone: 2,3-butanediol. ( Dietz, FK; Traiger, GJ, 1979) |
| " The result suggests that the acquired resistance to a toxic dose of furylfuramide is due to the acceleration of detoxication of the drug." | 1.26 | Development of resistance to hepatotoxic effect of furylfuramide by pretreatment with its subnecrotic doses and carbon tetrachloride. ( Horiuchi, T; Ohtsubo, K; Saito, M, 1978) |
| "The tumour growth, dehydration and burning of rats as well as sleep deprivation, overheating, lanthanum and ruthenium red have been shown to cause changes in the activity of some enzyme-systems located in endoplasmic reticulum." | 1.26 | Effect of different factors modifying the activity of some enzyme systems of the endoplastic reticulum on the sensitivity of cell organelles against the damaging action of chemical agents. I: Interrelations between the activity of some enzyme systems loca ( Geneva, L; Georgiev, G; Popov, CS; Yantchev, I, 1976) |
| " These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency." | 1.26 | Quantitative aspects in the assessment of liver injury. ( Plaa, GL, 1976) |
| " Prior dosing with phenobarbitone augments CCl4 toxicity only in the adult and the newborn but the foetus continues to be resistant." | 1.25 | Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. ( Chopra, P; Das, PK; Dhar, A; Nayak, NC, 1975) |
| "Mice were given a first dose of dimethylnitrosamine (DMN) and the LD50 of a second dose determined at various times later." | 1.25 | The effect of a dose of dimethylnitrosamine on the toxicity of a subsequent dose and on the toxicity of carbon tetrachloride in mice. ( Pound, AW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 376 (19.07) | 18.7374 |
| 1990's | 209 (10.60) | 18.2507 |
| 2000's | 383 (19.42) | 29.6817 |
| 2010's | 857 (43.46) | 24.3611 |
| 2020's | 147 (7.45) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 2 |
| Chen, Y | 28 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Krekhovska-Lepiavkob, OM | 1 |
| Lokay, BA | 1 |
| Yastremska, SO | 1 |
| Danchak, SV | 1 |
| Mazur, LP | 1 |
| Ogbonna Okoro, C | 1 |
| Aloke, C | 1 |
| Ibiam, UA | 1 |
| Obasi, NA | 1 |
| Orji, OU | 1 |
| Ogbonnia, EC | 1 |
| Ogbu, PN | 1 |
| Emelike, CU | 1 |
| Ufebe, GO | 1 |
| Nwamaka Ezeani, N | 1 |
| Zhao, W | 4 |
| Zhang, X | 15 |
| Hou, M | 2 |
| Zhang, Y | 28 |
| Tang, Y | 4 |
| Li, L | 19 |
| Dong, S | 3 |
| Liu, L | 8 |
| Zhao, D | 1 |
| Li, W | 12 |
| Nan, Y | 1 |
| Xu, G | 2 |
| Lv, X | 1 |
| Feng, Y | 8 |
| Li, H | 15 |
| Chen, C | 5 |
| Lin, H | 1 |
| Wang, C | 11 |
| Chen, J | 14 |
| Sun, J | 3 |
| Wang, S | 13 |
| Ding, Y | 4 |
| Dong, R | 1 |
| Wang, H | 21 |
| Yin, L | 8 |
| Meng, S | 1 |
| Lafoz, E | 1 |
| Campreciós, G | 1 |
| García-Calderó, H | 1 |
| Anton, A | 1 |
| Vilaseca, M | 1 |
| Ruart, M | 1 |
| Guasch, E | 1 |
| Garrabou, G | 1 |
| Delgado, TC | 1 |
| Martínez-Chantar, ML | 2 |
| García-Martínez, R | 1 |
| Gracia-Sancho, J | 1 |
| Hernández-Gea, V | 1 |
| García-Pagán, JC | 1 |
| Zhu, H | 3 |
| Zhao, H | 6 |
| Xu, S | 2 |
| Li, J | 31 |
| Huang, C | 9 |
| Ma, T | 1 |
| Shaban, NZ | 5 |
| Yehia, SA | 1 |
| Awad, D | 1 |
| Shaban, SY | 1 |
| Saleh, SR | 1 |
| Le, TV | 1 |
| Dinh, NBT | 1 |
| Dang, MT | 1 |
| Phan, NCL | 1 |
| Dang, LTT | 1 |
| Grassi, G | 1 |
| Holterman, AXL | 1 |
| Le, HM | 1 |
| Truong, NH | 1 |
| Biswas, S | 2 |
| Kar, A | 1 |
| Sharma, N | 5 |
| Haldar, PK | 1 |
| Mukherjee, PK | 5 |
| Sherikar, A | 1 |
| Siddique, MUM | 1 |
| More, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Effect of Oral Administration of a Herbarium Mixture (Guazuma Ulmifolia and Tecoma Stans) on Metabolic Profile in Type 2 Diabetic Patients[NCT03313856] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2010-01-10 | Completed | ||
| A Phase II Study of PD-0332991 in Adult Patients With Advanced Hepatocellular Carcinoma[NCT01356628] | Phase 2 | 23 participants (Actual) | Interventional | 2011-05-25 | Active, not recruiting | ||
| A Multiple-Dose Research Study on Safety Evaluation of the GD Antrodia Camphorata in 30 Healthy Adult Subjects[NCT01007656] | 31 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number and nature of adverse events as a measure of safety and tolerability. Safety analysis will be conducted on all patients who receive at least one dose of PD-0332991 during the study period or follow-up. An adverse event is any unfavorable and unintended sign, symptom, syndrome or illness that develops during the period of observation in the clinical study, including a new illness or condition, worsening of a concomitant illnesses or condition, effect of the study medication or combination of 2 or more factors. (NCT01356628)
Timeframe: From date of randomization through study completion, assessed up to 100 months
| Intervention | Adverse Events (Number) |
|---|---|
| PD-0332991 | 504 |
Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST Version 1.1), as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). The appearance of one or more new lesions is also considered progression. (NCT01356628)
Timeframe: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months
| Intervention | months (Mean) |
|---|---|
| PD-0332991 | 8 |
(NCT01007656)
Timeframe: 90 days
| Intervention | g/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 4.74 |
(NCT01007656)
Timeframe: 90 days
| Intervention | U/L (Mean) |
|---|---|
| GD Antrodia Camphorata | 55.81 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 9.32 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 173.13 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 0.84 |
Direct bilirubin is referred to as conjugated bilirubin, which is water-soluble. It's taken up by the liver cells and conjugated to form the water-soluble bilirubin diglucuronide. It's used to diagnose and/or monitor liver diseases, such as cirrhosis, hepatitis or gallstones. If direct bilirubin is elevated more than unconjugated bilirubin, there's typically a problem associated with decreased elimination of bilirubin by the liver cells. (NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 0.10 |
(NCT01007656)
Timeframe: 90 days
| Intervention | g/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 2.51 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 80.13 |
(NCT01007656)
Timeframe: 90 days
| Intervention | U/L (Mean) |
|---|---|
| GD Antrodia Camphorata | 17.42 |
(NCT01007656)
Timeframe: 90 days
| Intervention | U/L (Mean) |
|---|---|
| GD Antrodia Camphorata | 21.48 |
(NCT01007656)
Timeframe: 90 days
| Intervention | U/L (Mean) |
|---|---|
| GD Antrodia Camphorata | 21.94 |
Bilirubin is released into the blood when red blood cells break down. The liver uses bilirubin to make bile. Normally there is only a small amount of bilirubin in the blood. High levels may be caused by liver or blood problems. (NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 0.73 |
The total protein test measures the total amount of two classes of proteins in the blood, albumin and globulin. (NCT01007656)
Timeframe: 90 days
| Intervention | g/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 7.25 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 56.39 |
(NCT01007656)
Timeframe: 90 days
| Intervention | mg/dL (Mean) |
|---|---|
| GD Antrodia Camphorata | 5.47 |
41 reviews available for carbon tetrachloride and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Therapeutic effects of N-acetyl-L-cysteine on liver damage induced by long-term CCl4 administration.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Ch | 2018 |
Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and D | 2019 |
Animal models of drug-induced liver injury.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2019 |
[Hepatoprotective effects of extracts and polysaccharides from seaweed].
Topics: Acetaminophen; Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2014 |
Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review.
Topics: Aflatoxins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hum | 2016 |
Role of hemostatic factors in hepatic injury and disease: animal models de-liver.
Topics: Animals; Bile Ducts; Blood Coagulation; Blood Coagulation Disorders; Carbon Tetrachloride; Chemical | 2016 |
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Liver; Hu | 2016 |
[Meta-analysis on impact of Danshen on liver regeneration in rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2012 |
Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model.
Topics: Age Factors; Alkanes; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2003 |
Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2003 |
[Learning toxicology from carbon tetrachloride-induced hepatotoxicity].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Liver; Hepatocytes; Lip | 2006 |
[Application of mesenchymal stem cells to liver regenerative medicine].
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical an | 2008 |
Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Cytochr | 1984 |
A new direction in the study of carbon tetrachloride hepatotoxicity.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Compartmentation; Chemi | 1983 |
Mechanisms of cell injury with hepatotoxic chemicals.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1984 |
Free-radical mechanisms in tissue injury.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Cell Survival; Chemical and Drug Induced Liver Injury; C | 1984 |
Calcium and the mechanisms of liver necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; Galac | 1982 |
Alterations in chemically induced tissue injury related to all-trans-retinol pretreatment in rodents.
Topics: Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Etha | 1995 |
[Etiological mechanism of toxic hepatitis].
Topics: Alcohol Drinking; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug-Relate | 1995 |
Liver damage due to free radicals.
Topics: Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 1993 |
Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity.
Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone | 1996 |
The liver as a target for chemical-chemical interactions.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Drug Antagoni | 1997 |
Sinusoidal intercellular adhesion molecule-1 up-regulation precedes the accumulation of leukocyte function antigen-1-positive cells and tissue necrosis in a model of carbontetrachloride-induced acute rat liver injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Separation; Chemical and Drug Induced Liver Injur | 1998 |
[Inhibitory effect of green tea infusion of hepatotoxicity].
Topics: Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Flavonoids; Galacto | 1998 |
NSAID zaltoprofen improves the decrease in body weight in rodent sickness behavior models: proposed new applications of NSAIDs (Review).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Body Weight; Carbon Tetrachloride; Ch | 2002 |
Hepatic drug metabolism and adverse hepatic drug reactions.
Topics: Adaptation, Biological; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poiso | 1975 |
Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Synergism; | 1989 |
Regulation of extrarenal erythropoietin production.
Topics: Angiotensin II; Animals; Atmospheric Pressure; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1989 |
Mechanisms of carbon tetrachloride hepatotoxicity.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enz | 1989 |
[Biochemical semiology of the liver in ruminants].
Topics: 5'-Nucleotidase; Alanine Transaminase; Alkaline Phosphatase; Animals; Arginase; Artiodactyla; Aspart | 1986 |
[Biochemical and pharmacologic effects of wuweizi (Schizandra chinensis (Turcz.) Baill.) and its chemical contents on animal livers].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-45 | 1988 |
Free radicals and tissue injury: fact and fiction.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fr | 1987 |
Solvent toxicology: recent advances in the toxicology of benzene, the glycol ethers, and carbon tetrachloride.
Topics: Animals; Benzene; Blood Cells; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1987 |
The biochemical pathology of toxic cell death.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membra | 1985 |
[Environmental pollutants and toxic hepatitis].
Topics: Carbon Monoxide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Environmental Exposur | 1985 |
Metabolism of volatile anaesthetics.
Topics: Adipose Tissue; Anesthetics; Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 1972 |
Halothane hepatitis. Current concepts.
Topics: Anesthesia, General; Animals; B-Lymphocytes; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1974 |
Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1973 |
Intravascular coagulation in liver disease.
Topics: Animals; Blood Coagulation Factors; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Di | 1974 |
[Alcohol and liver disorders].
Topics: Adult; Alcoholic Beverages; Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liv | 1969 |
3 trials available for carbon tetrachloride and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Influence of liver's oxide-reductive homeostasis disorder for AKBR values in rabbit's arterial blood.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Homeostasis; Ketone B | 2007 |
[Clinical and experimental study on effect of ganyan IV in treatment of chronic active hepatitis complicated with hyperbilirubinemia].
Topics: Adolescent; Adult; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Thera | 1996 |
1929 other studies available for carbon tetrachloride and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Assessment of nitrogen metabolism in rats on the background of acute toxic hepatitis and it's correction with l-arginin and l-ornitin.
Topics: Animals; Arginine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced L | 2021 |
Studies on Ethanol Extracts of
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2021 |
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Topics: Adult; Animals; Antifibrotic Agents; Antiviral Agents; Carbon Tetrachloride; Case-Control Studies; C | 2021 |
Study on the effect of active components of Schisandra chinensis on liver injury and its mechanisms in mice based on network pharmacology.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Disease Mod | 2021 |
Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase.
Topics: Activating Transcription Factor 4; Adenylate Kinase; Animals; Aspartate-Ammonia Ligase; Canagliflozi | 2021 |
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats.
Topics: Animals; Caloric Restriction; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Energy I | 2021 |
Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and | 2021 |
A Titanium (IV)-Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Chemical | 2021 |
Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroquine; Disea | 2022 |
Synergistic effect of ursolic acid and piperine in CCl
Topics: Alkaloids; Animals; Benzodioxoles; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hum | 2021 |
Preparation and Evaluation of Silymarin-Loaded Solid Eutectic for Enhanced Anti-Inflammatory, Hepatoprotective Effect:
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Carrageenan; Central Nervous System Depress | 2021 |
A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Plant Ext | 2020 |
Protective Effect of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Supplem | 2021 |
The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Carbon Tetrachloride; Carica | 2021 |
Effects and mechanisms of ziqi ruangan decoction on hepatic fibrosis.
Topics: Actins; Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Antioxidants; Carbon Tetrachloride; | 2021 |
Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachloride.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Ci | 2022 |
Topics: Agaricales; Animals; Animals, Outbred Strains; Antioxidants; Carbon Tetrachloride; Chemical and Drug | 2022 |
Protective Effects of Naringenin from
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Citrus sinensis | 2022 |
Traditional Mongolian medicine (HHQG) attenuates CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokines; Liver; Macrophage | 2022 |
Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2022 |
Beneficial effects of coconut oil (Cocos nucifera) on hematobiochemicl and histopathological markers in CCL4-intoxicated rabbits.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coconut Oil; Cocos; Rabbits | 2022 |
Nonlinear molecular dynamics of quercetin in Gynocardia odorata and Diospyros malabarica fruits: Its mechanistic role in hepatoprotection.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cyto | 2022 |
Nicotine exposure of male mice protects offspring against carbon tetrachloride-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; | 2022 |
S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Dr | 2022 |
Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2022 |
Silibinin Schiff Base Derivatives Counteract CCl
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2022 |
Protective effects of dexpanthenol in carbon tetrachloride-induced myocardial toxicity in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipid Peroxidat | 2022 |
Is human umbilical cord mesenchymal stem cell-derived conditioned medium effective against oxidative and inflammatory status in CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Culture Media, | 2022 |
RIPK1 in Liver Parenchymal Cells Limits Murine Hepatitis during Acute CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Drug | 2022 |
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Fibr | 2022 |
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury.
Topics: Animals; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide | 2022 |
The underlying hepatoprotective mechanism of PKC#963 in alcohol or carbon tetrachloride induced liver injury via inhibition of iNOS, COX-2, and p-STAT3 and enhancement of SOD and catalase.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injur | 2023 |
Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrac | 2022 |
Hepatoprotective effect of Cordia rothii extract against CCl
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced | 2022 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Protective Effects of
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 2022 |
A novel type lavandulyl flavonoid from Sophora flavescens as potential anti-hepatic injury agent that inhibit TLR2/NF-κB signaling pathway.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Humans; Liver; Mi | 2023 |
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flax; Hydrogen | 2023 |
Peptides from Antarctic krill (
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Euphausiacea; Kelch-Like ECH- | 2023 |
Dynamics of Chronic Liver Injury in Experimental Models of Hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Human | 2023 |
Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS.
Topics: Acetaminophen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Hepatocytes; H | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acrylamides; Actins; Adult; African People; Air Pollutants; Alanine Transaminase; Androgens; Animals | 2023 |
Serum metabolome profiling, network pharmacology analysis, and experimental validation of Anoectochilus roxburghii in the treatment of carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2023 |
An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity.
Topics: Alanine Transaminase; Animals; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2023 |
[Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis].
Topics: Alkaline Phosphatase; Animals; Animals, Laboratory; Antioxidants; Carbon Tetrachloride; Chemical and | 2023 |
Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Flavono | 2023 |
Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.
Topics: Adjuvants, Immunologic; Amino Acids; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced L | 2023 |
Hepatodamianol as hepatoprotective constituent of Turnera diffusa.
Topics: Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Plant Extracts; T | 2023 |
Antioxidant and hepatopreventive effects of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipid Peroxidat | 2021 |
Structural characterization and in vitro hepatoprotective activity of polysaccharide from pine nut (Pinus koraiensis Sieb. et Zucc.).
Topics: Alanine Transaminase; Aspartate Aminotransferases; Carbohydrate Sequence; Carbon Tetrachloride; Cell | 2019 |
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Berberine; Carbon Tetrachloride; Chemical and Dru | 2019 |
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Doc | 2019 |
Jiang-Zhi granules decrease sensitivity to low-dose CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diet, High-Fat; Drugs, Chines | 2019 |
Disodium Guanylate Alleviates Acute Hepatic Injury Induced by Carbon Tetrachloride Via Antioxidative Stress and Antiapoptosis In Vivo and In Vitro.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Guan | 2019 |
Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Immune System; Immunomodulati | 2019 |
Hesperetin derivative attenuates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; C | 2019 |
Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Carbon Tetrachlori | 2019 |
[Effects of total C-21 steroidal glucosides from Cynanchum auriculatum on oxidative stress pathway in mice with liver injury].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cynanchum; Glucosides; Hepato | 2019 |
In vitro hepatoprotective activity of Sargassum wightii against CCl4 induced hepatic damage.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorocebus aethio | 2019 |
Therapeutic applications of adipose-derived mesenchymal stem cells on acute liver injury in canines.
Topics: Adipose Tissue; Administration, Intravenous; Alanine Transaminase; Animals; Aspartate Aminotransfera | 2019 |
Endogenous beta-galactosidase activity marks a TREM2-expressing Kupffer cell population in injured livers of Lgr5-LacZ and wild-type mice.
Topics: Animals; beta-Galactosidase; Carbon Tetrachloride; Cell Lineage; Cells, Cultured; Chemical and Drug | 2020 |
Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents, Local | 2020 |
A strategy for quality evaluation of salt-treated Apocyni Veneti Folium and discovery of efficacy-associated markers by fingerprint-activity relationship modeling.
Topics: Animals; Apocynum; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromat | 2019 |
Cross-regulation by TLR4 and T cell Ig mucin-3 determines severity of liver injury in a CCl4-induced mouse model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2020 |
Evaluation of biological activities and in vivo amelioration of CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response R | 2020 |
Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice.
Topics: Acute Disease; Acute-On-Chronic Liver Failure; Adult; Animals; Carbon Tetrachloride; Chemical and Dr | 2020 |
SanWeiGanJiang San relieves liver injury via Nrf2/Bach1.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Carbon Tetrachloride; Chemical and Drug Induced | 2020 |
Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.
Topics: Adenosine Triphosphate; Animals; Antigens, Differentiation, T-Lymphocyte; bcl-X Protein; Carbon Tetr | 2020 |
Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade.
Topics: Animals; Carbon Tetrachloride; Carnitine O-Palmitoyltransferase; CDC2 Protein Kinase; Cells, Culture | 2020 |
Genipin Ameliorates Carbon Tetrachloride-Induced Liver Injury in Mice via the Concomitant Inhibition of Inflammation and Induction of Autophagy.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2019 |
Inhibiting alpha subunit of eukaryotic initiation factor 2 dephosphorylation protects injured hepatocytes and reduces hepatocyte proliferation in acute liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2019 |
Accelerated liver recovery after acute CCl
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2020 |
Development of TPGS/F127/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Indu | 2020 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
Endoplasmic Reticulum Stress Increases Multidrug-resistance Protein 2 Expression and Mitigates Acute Liver Injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 2020 |
Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen Type I | 2020 |
AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity
Topics: Animals; Antioxidants; Apoptosis; Benzamides; Carbon Tetrachloride; Cells, Cultured; Chemical and Dr | 2020 |
Isolation and characterization of flavonoid derivatives with anti-prostate cancer and hepatoprotective activities from the flowers of Hosta plantaginea (Lam.) Aschers.
Topics: Antineoplastic Agents; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Flav | 2020 |
Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver; Liver Cir | 2020 |
Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Indu | 2020 |
Transcriptomics and proteomics analysis of system-level mechanisms in the liver of apigenin-treated fibrotic rats.
Topics: Alanine Transaminase; Albumins; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Apigenin; A | 2020 |
Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.
Topics: Animals; Biopsy; Capillaries; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2020 |
Evaluation of Hepatoprotective Activity of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clerodendrum; C | 2020 |
Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity.
Topics: Acanthaceae; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrac | 2020 |
Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS.
Topics: Angiotensin-Converting Enzyme 2; Animals; Antioxidants; Autophagy; Carbon Tetrachloride; Cells, Cult | 2020 |
Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.
Topics: Animals; Antioxidant Response Elements; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced L | 2020 |
Lignans from Schisandra chinensis ameliorate alcohol and CCl
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver I | 2020 |
Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Flavonoids; Mice; | 2020 |
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Topics: Acetaminophen; Animals; Blood Platelets; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2020 |
A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol; Disease Models, | 2020 |
Dysregulation of UDP-glucuronosyltransferases in CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Gene Expression Reg | 2020 |
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Carbon Tetrachloride; Carcinogenesis; Car | 2021 |
Dihydro-stilbene gigantol relieves CCl
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Bibenzyls; Carbon Tetrachlori | 2020 |
A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Chemical and Dru | 2020 |
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Intubation, Ga | 2020 |
Celastrol ameliorates acute liver injury through modulation of PPARα.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Mice; Mice, 129 Strain; | 2020 |
Hepatoprotective effects of Di Wu Yang Gan: A medicinal food against CCl
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; C | 2020 |
Isolation and purification of immune cells from the liver.
Topics: Animals; Carbon Tetrachloride; Cell Separation; Chemical and Drug Induced Liver Injury; Collagenases | 2020 |
Dendrobium nobile Lindl. alkaloids-mediated protection against CCl
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2020 |
Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation.
Topics: Animals; Carbon Tetrachloride; Caspases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CY | 2020 |
Inhibition of eIF2
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; eIF-2 K | 2020 |
[Mechanism of psoralen in aggravating hepatotoxicity induced by CCl_4 by delaying liver regeneration].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2020 |
Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice.
Topics: Animals; Apoptosis; Biopsy; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2020 |
Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Chemical and Drug Induced Liver Injury; Disease Models | 2020 |
Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2020 |
Protective Effect of Antioxidative Liposomes Co-encapsulating Astaxanthin and Capsaicin on CCl
Topics: Acute Disease; Animals; Antioxidants; Capsaicin; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2020 |
A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo.
Topics: Animals; Antioxidants; Biphenyl Compounds; Caffeic Acids; Carbon Tetrachloride; Catalase; Chemical a | 2021 |
Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Capsaicin; Carbon Tetrachloride; Cell Line; Cell Proliferation; C | 2020 |
A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Li | 2021 |
Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo.
Topics: alpha-Amylases; alpha-Glucosidases; Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride; Chem | 2020 |
Pilea umbrosa ameliorate CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2020 |
The evaluation of hepatoprotective effects of flavonoids from
Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Liver; NF-kappa B; Oxidati | 2022 |
Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2020 |
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2021 |
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Che | 2020 |
Recovery Dynamics of Intestinal Bacterial Communities of CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dysbiosis; Gastrointestinal M | 2020 |
Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bile Ducts; Carbon Tetrachloride; Cell Proliferation; | 2021 |
Marchantia polymorpha L. Flavonoids Protect Liver From CCl4-Induced Injury by Antioxidant and Gene-Regulatory Effects.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Hum | 2022 |
Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats.
Topics: Acetaminophen; Acute Disease; Amino Acids; Animals; Biomarkers; Bromobenzenes; Carbon Tetrachloride; | 2020 |
Codonopis bulleynana Forest ex Diels (cbFeD) effectively attenuates hepatic fibrosis in CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Chemota | 2021 |
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Topics: AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Ind | 2021 |
Hepatoprotective effect of apolipoprotein A4 against carbon tetrachloride induced acute liver injury through mediating hepatic antioxidant and inflammation response in mice.
Topics: Animals; Antioxidants; Apolipoproteins A; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2021 |
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2021 |
Phenolic compounds and hepatoprotective potential of Anastatica hierochuntica ethanolic and aqueous extracts against CCl4-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Brassicaceae; Carbon Tetrachloride; Chem | 2020 |
Hepatoprotective Impact of Geraniol Against CCl
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemica | 2020 |
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl
Topics: Amygdalin; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; Cell Proliferation; C | 2021 |
Curcumin-containing Silver Nanoparticles Prevent Carbon Tetrachloride- induced Hepatotoxicity in Mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Liver; Male; Metal | 2021 |
Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cell Proliferati | 2020 |
Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil.
Topics: Alanine Transaminase; Animals; Antifungal Agents; Antioxidants; Aspartate Aminotransferases; Carbon | 2021 |
Branched-chain amino acids and l-carnitine attenuate lipotoxic hepatocellular damage in rat cirrhotic liver.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Carnitine; Cell Death; Chemical and Drug | 2021 |
LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, | 2022 |
Phytochemical Screening and Protective Effects of Prunus persica Seeds Extract on Carbon Tetrachloride-Induced Hepatic Injury in Rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Mice; Ox | 2022 |
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2021 |
RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; CRISPR-Cas S | 2021 |
The novel effect of propranolol in glibenclamide induced hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2020 |
Hepatoprotective and antioxidant activity of Dicliptera bupleuroides Nees. extracts on paracetamol induced hepatotoxicity in rats.
Topics: Acanthaceae; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Carbon Tetrachloride; C | 2020 |
Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver | 2021 |
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Bile Acids and Salts; Biomarkers; Carbon Tet | 2021 |
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Galactosamine; Hum | 2021 |
Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl
Topics: Animals; Animals, Outbred Strains; Antioxidants; Carbon Tetrachloride; Cells, Cultured; Chemical and | 2021 |
Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2020 |
Heliconia rostrata rhizomes mitigate chemical-induced liver injury by debilitating oxidative stress in HepG2 cells and rats.
Topics: Animals; Antioxidants; Body Weight; Carbon Tetrachloride; Cell Death; Chemical and Drug Induced Live | 2021 |
Structural characterization and hepatoprotective activity of a galactoglucan from Poria cocos.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Constitutive Andro | 2021 |
The protective effects of the
Topics: Agaricales; Agrocybe; Animals; Antioxidants; Basidiomycota; Carbon Tetrachloride; Chemical and Drug | 2022 |
Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion.
Topics: Acetaminophen; Animals; Animals, Genetically Modified; Blood Circulation; Carbon Tetrachloride; Cart | 2021 |
Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2021 |
Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Ind | 2021 |
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Indu | 2021 |
Hepatoprotective effect of ethanolic extract of sugarcane (
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemica | 2021 |
Amelioration of Experimental Hepatotoxicity in Rats by Portulaca oleracea Linn. from Kashmir Himalaya.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver Diseases; | 2022 |
Protective effect of Phaeoporus obliquus polysaccharide against acute liver injury induced by carbon tetrachloride and alcohol in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2021 |
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Heme Oxygenase (Decyclizing); | 2021 |
Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2021 |
Comparison of the Effects of Intraperitoneal Injection with Carbon Tetrachloride on Acute Liver Toxicity in Male and Female Kunming Mice.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2021 |
Hepatoprotective effect of Spirulina platensis against carbon tetrachloride-induced liver injury in male rats.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2021 |
Downregulation of fibrosis and inflammatory signalling pathways in rats liver
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2021 |
Caveolin-1 Deficiency Protects Mice Against Carbon Tetrachloride-Induced Acute Liver Injury Through Regulating Polarization of Hepatic Macrophages.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Caveolin 1; Chemical and Drug Induced Liver In | 2021 |
Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.
Topics: Activins; Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; | 2017 |
Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corydalis; Liver; | 2017 |
The Protective Effects of Helix B Surface Peptide on Experimental Acute Liver Injury Induced by Carbon Tetrachloride.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; A | 2017 |
Gallic Acid and Dodecyl Gallate Prevents Carbon Tetrachloride-Induced Acute and Chronic Hepatotoxicity by Enhancing Hepatic Antioxidant Status and Increasing p53 Expression.
Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2017 |
Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress.
Topics: Animals; Antioxidants; Biopsy; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver | 2017 |
Effect of oxymatrine HSPC liposomes on improving bioavailability, liver target distribution and hepatoprotective activity of oxymatrine.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biological Availability; Carb | 2017 |
In Vitro Antioxidant Activities of Enzymatic Hydrolysate from Schizochytrium sp. and Its Hepatoprotective Effects on Acute Alcohol-Induced Liver Injury In Vivo.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cata | 2017 |
Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Epithelial-Mesench | 2017 |
Antioxidant and hepatoprotective activities of Dicoma anomala\
Sond. aqueous root extract against carbon tetrachloride-induced\
liver damage in Wistar rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Asteraceae; Carbon Tetrach | 2016 |
Hepatoprotective effects of Vaccinium arctostaphylos against CCl4-induced acute liver injury in rats.
Topics: Animals; Antioxidants; Arctostaphylos; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced L | 2017 |
Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Respons | 2017 |
Silymarin-Loaded Eudragit Nanoparticles: Formulation, Characterization, and Hepatoprotective and Toxicity Evaluation.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2017 |
Apocynin prevented inflammation and oxidative stress in carbon tetra chloride induced hepatic dysfunction in rats.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; | 2017 |
2-Hydroxy-4-methoxy benzoic acid attenuates the carbon tetra chloride-induced hepatotoxicity and its lipid abnormalities in rats via anti-inflammatory and antioxidant mechanism.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoates; Carbon Tetrachloride; Chemical and Drug | 2017 |
Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Chemical and Drug Induced Li | 2017 |
[STUDY OF HEPATOPROTECTIVE PROPERTIES OF RNA-CONTAINING DRUG "RN-13" ON THE MODEL OF ACUTE TETRAHLLORMETHANE INDUCED HEPATITIS IN RATS].
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection | 2017 |
Transplant of Hepatocytes, Undifferentiated Mesenchymal Stem Cells, and In Vitro Hepatocyte-Differentiated Mesenchymal Stem Cells in a Chronic Liver Failure Experimental Model: A Comparative Study.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical and Drug | 2018 |
Hepatoprotective Effect of Aqueous Extract from the Seeds of Orychophragmus violaceus against Liver Injury in Mice and HepG2 Cells.
Topics: Animals; Brassicaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hep G2 Cells; H | 2017 |
Role of growth factor receptor-bound 2 in CCl
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced Live | 2017 |
Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrachloride; Cell Line; Cells, Cultured; Chem | 2017 |
Comparative study on Artemisia halodendron Turcz. and its two related plants by GC-MS analysis and protective effect against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Artemisia; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 2018 |
Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical a | 2017 |
Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride‑induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; Cells, | 2017 |
YAP determines the cell fate of injured mouse hepatocytes in vivo.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; cdc42 GTP-Binding Protein; Cell | 2017 |
4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endocanna | 2017 |
Pien Tze Huang Gan Bao attenuates carbon tetrachloride‑induced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Her | 2017 |
Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cell Proliferation; C | 2017 |
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Design; Liver; Male; Mic | 2017 |
Seabuckthorn berry polysaccharide protects against carbon tetrachloride-induced hepatotoxicity in mice via anti-oxidative and anti-inflammatory activities.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2017 |
Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl
Topics: Amino Acids; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese H | 2017 |
Mosapride Stabilizes Intestinal Microbiota to Reduce Bacterial Translocation and Endotoxemia in CCl
Topics: Animals; Bacterial Translocation; Benzamides; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2017 |
Hepatoprotective and antioxidant effects of single clove garlic against CCl
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachl | 2017 |
Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Bacterial Translocation; Carbon Tetrachloride; | 2018 |
Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver | 2017 |
Von Willebrand factor protects against acute CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endothelium, Vascular; Extrac | 2017 |
Hepatoprotective effects of Yulangsan flavone against carbon tetrachloride (CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; China; Drugs, Chinese Herbal; | 2017 |
Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
Topics: Acetaminophen; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Flavonoids; | 2017 |
The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2017 |
Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Carbon Tetrachlor | 2018 |
Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Compu | 2017 |
Protective potential of Parrotiopsis jacquemontiana (Decne) Rehder on carbon tetrachloride induced hepatotoxicity in experimental rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Dise | 2017 |
S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Typ | 2018 |
Protective effects of traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2017 |
[Protective effects of five different types of Dendrobium on CCl4-induced liver injury in mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; China; Dendrobium; Liver; Mic | 2017 |
Chinese herbal formula Fuzheng Huayu alleviates CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2B1; Cyto | 2018 |
A hepatonephro-protective phenolic-rich extract from red onion (Allium cepa L.) peels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemi | 2017 |
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Enhance | 2018 |
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2018 |
Biogenic selenium and its hepatoprotective activity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line; Chemical and | 2017 |
The potential protective effect of Commelina nudiflora L. against carbon tetrachloride (CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Commelina; Dose | 2017 |
A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Hep | 2017 |
Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl
Topics: Acetates; Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Antioxidants; Biomarkers | 2018 |
Abrogation of carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats by Ajwa date fruit extract through ameliorating oxidative stress and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2017 |
Allium tuberosum: Antidiabetic and hepatoprotective activities.
Topics: Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Live | 2017 |
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytokines; E | 2017 |
Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats: Hepatoprotection at molecular level.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytoprotection; Inf | 2018 |
Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response.
Topics: Animals; Butylated Hydroxyanisole; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dua | 2018 |
S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Li | 2018 |
Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2018 |
Hepatoprotective properties for Salvia cryptantha extract on carbon tetrachloride-induced liver injury.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Camphanes; Carbon Tetrachloride; Caspa | 2017 |
The Hepatoprotective Effect of Selenium-Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride-Induced Chronic Liver Injury in Rats.
Topics: Acacia; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical a | 2018 |
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 9; Chemical and Drug Induced Liver Injury; Curcumi | 2018 |
Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Euphorbiaceae; Hep | 2018 |
Potential roles of AMP-activated protein kinase in liver regeneration in mice with acute liver injury.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemic | 2018 |
mRNA chip-based analysis on transcription factor regulatory network central nodes of protection targets of Deproteinized Extract of Calf Blood on acute liver injury in mice.
Topics: Animals; Blood; Carbon Tetrachloride; Cattle; Cell Extracts; Chemical and Drug Induced Liver Injury; | 2018 |
Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Blood Urea Nitrog | 2017 |
Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10.
Topics: Actins; Androstadienes; Animals; Anti-Inflammatory Agents; Aromatase Inhibitors; Bile Ducts; Carbon | 2017 |
Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2018 |
Validation of the antihyperglycaemic and hepatoprotective activity of the flavonoid rich fraction of Brachychiton rupestris using in vivo experimental models and molecular modelling.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2018 |
Effective Protection on Acute Liver Injury by Halo Tag-Flanked Recombinant Fibroblast Growth Factor 7.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Chemical and Drug Induced L | 2018 |
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MELILOTUS OFFICINALIS L. AGAINST PARACETAMOL AND CARBON TETRACHLORIDE INDUCED HEPATIC INJURY IN MICE.
Topics: Acetaminophen; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cy | 2017 |
Chemical composition and hepatoprotective effect of free phenolic extract from barley during malting process.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liv | 2018 |
Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway.
Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; | 2018 |
Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation.
Topics: Animals; Apigenin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Gene | 2018 |
Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL‑7702 cell line.
Topics: Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; C | 2018 |
Metabolic profiling of endogenous bile acids: a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Carbon | 2018 |
Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Crot | 2018 |
Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Line; Chemica | 2018 |
Dual protective effect of ginger and rosemary extracts against CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Ox | 2018 |
Antioxidant, Hepatoprotective, and Antidepression Effects of
Topics: Animals; Antidepressive Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2018 |
Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Dise | 2018 |
Dimethylthiourea ameliorates carbon tetrachloride-induced acute liver injury in ovariectomized mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2018 |
Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice.
Topics: Activating Transcription Factor 4; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbo | 2018 |
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 2018 |
Protective effect of an arabinogalactan from black soybean against carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactans; Glyc | 2018 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2018 |
Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Citric Acid Cyc | 2018 |
Consumption of Goats' Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated Gut Microbiota Imbalance.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2018 |
Ellagic acid impedes carbontetrachloride-induced liver damage in rats through suppression of NF-kB, Bcl-2 and regulating Nrf-2 and caspase pathway.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Dam | 2018 |
Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 2018 |
Antioxidant and Hepatoprotective Activities of Crude Polysaccharide Extracts from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by Ultrasonic-Circulating Extraction.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2018 |
Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Cytopr | 2018 |
The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Becaplermin; Carbon Tetrach | 2018 |
Lycium europaeum Linn as a source of polysaccharide with in vitro antioxidant activities and in vivo anti-inflammatory and hepato-nephroprotective potentials.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Carrageen | 2018 |
Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; D | 2018 |
DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; DNA (Cytosine-5-)- | 2018 |
Protective aptitude of Periploca hydaspidis Falc against CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Periploca; Plant | 2018 |
Hyaluronan as a mediator for the hepatoprotective effect of Diosmin/Hesperidin complex.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diosmin; Drug Combinations; G | 2018 |
Hepatoprotective Effects of
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hot Temperature; Lactobacillu | 2018 |
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response | 2018 |
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Down-Regulat | 2018 |
Hepatoprotective potential of Malvaviscus arboreus against carbon tetrachloride-induced liver injury in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; | 2018 |
The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Flavorin | 2018 |
Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice.
Topics: Animals; Apoptosis; Biological Products; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2018 |
Pharmacokinetics and Preventive Effects of Sulfo-Albumin as a Novel Macromolecular Hydrogen Sulfide Prodrug on Carbon Tetrachloride-Induced Hepatic Injury.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2018 |
Polyphenols in Liubao Tea Can Prevent CCl₄-Induced Hepatic Damage in Mice through Its Antioxidant Capacities.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2018 |
[Comparative Study on Protection Effects of CCl4-Induced Acute Liver Injury of Different Prepared Products from Gardenia jasminoides Fruits in Rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Fruit; | 2016 |
Utility of Serum miR-122, Liver Enzymes, and Hepatic Histopathology in Response to Hepatotoxicants in Sprague-Dawley Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aniline Compounds; Animals; Biomarkers; Carbon Tetrachlo | 2018 |
Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice.
Topics: Animals; Benzofurans; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Concanavalin A; | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
The hydroethanolic Litchi chinensis leaf extract alleviate hepatic injury induced by carbon tetrachloride (CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Inflamm | 2018 |
Antioxidant Activity and Protective Effect of Carob Honey in CCl
Topics: Acute Kidney Injury; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induce | 2018 |
Potentials of Differentiated Human Cord Blood-Derived Unrestricted Somatic Stem Cells in Treatment of Liver Cirrhosis.
Topics: Adult Stem Cells; Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferatio | 2019 |
Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultu | 2019 |
Protective effects of
Topics: Animals; Anti-Inflammatory Agents; Antimutagenic Agents; Bidens; Carbon Tetrachloride; Chemical and | 2021 |
Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol-bound punicic acid for increased antihepatotoxic activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Carbon Tetrachloride; Chem | 2019 |
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Typ | 2019 |
Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Arylamine N-Acetyltransferase; Autophagosomes; Au | 2019 |
Protective Effects of Morus Root Extract (MRE) Against Lipopolysaccharide-Activated RAW264.7 Cells and CCl4-Induced Mouse Hepatic Damage.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2018 |
[Protective effects of Sedum sarmentosum under different soil moisture in CCl₄-induced damage in HepG2 cells].
Topics: Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Pl | 2018 |
Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Concanavalin A | 2018 |
The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Actinobacteria; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2019 |
Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice.
Topics: Animals; Antioxidants; Brassica rapa; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2019 |
Expression of Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and CD147 in the Traditional Chinese Medicine "Compound T11" for Treatment of Chronic Liver Injury.
Topics: Animals; Basigin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose | 2019 |
Potential anti-inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride-mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2019 |
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Collagen T | 2018 |
Phytochemical analysis and hepatoprotective effect of polyherbal formulation on CCl4 induced hepatotoxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2018 |
Ameliorative effect of Homalium zeylanicum against carbon tetrachloride-induced oxidative stress and liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2019 |
Protective effect of phenolic acids from Chebulae Fructus immaturus on carbon tetrachloride induced acute liver injury via suppressing oxidative stress, inflammation and apoptosis in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis; Liver; | 2020 |
Metabolic profile and hepatoprotective effect of Aeschynomene elaphroxylon (Guill. & Perr.).
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fab | 2019 |
Liver Macrophage Depletion Ameliorates The Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver.
Topics: Animals; Biometry; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2019 |
Standardized
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipid Peroxidat | 2020 |
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2019 |
Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Typ | 2019 |
Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Apoptosis; Carbon Tetrachlo | 2019 |
A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection.
Topics: A549 Cells; Aniline Compounds; Animals; Benzopyrans; Carbon Tetrachloride; Chemical and Drug Induced | 2019 |
Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Indu | 2019 |
Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-β1 Pathway.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chenopodium qui | 2019 |
Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Chemical and Dr | 2019 |
Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl
Topics: Administration, Oral; Animals; Area Under Curve; Carbon Tetrachloride; Cell Survival; Chemical and D | 2019 |
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas | 2021 |
Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clodronic Acid; Collagen Type | 2019 |
Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury.
Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemi | 2019 |
Multiomics analysis profile acute liver injury module clusters to compare the therapeutic efficacy of bifendate and muaddil sapra.
Topics: Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Humans; Metabolome | 2019 |
Human bone marrow-derived mesenchymal stromal cells in combination with silymarin regulate hepatocyte growth factor expression and genotoxicity in carbon tetrachloride induced hepatotoxicity in Wistar rats.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2019 |
Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl
Topics: Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Li | 2019 |
Optimization, characterization and hepatoprotective effect of polysaccharides isolated from Stipa parviflora Desf. against CCl
Topics: Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug I | 2019 |
Hepatoprotective effect of a polysaccharide from Radix Cyathulae officinalis Kuan against CCl
Topics: Amaranthaceae; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2019 |
Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Biocompatible Materials; Carbon Tetrachloride; Cell Line | 2019 |
Hepatoprotective effects of an Acer tegmentosum Maxim extract through antioxidant activity and the regulation of autophagy.
Topics: Acer; Animals; Antioxidants; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Cell Survival; Chemi | 2019 |
Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Respiration; Chemical and Drug Induced Liver Injury; | 2019 |
Methanol extract of Muntingia calabura leaves attenuates CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response R | 2019 |
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Elect | 2019 |
TG101348, a selective JAK2 antagonist, ameliorates hepatic fibrogenesis
Topics: 3T3 Cells; Animals; Carbon Tetrachloride; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; | 2019 |
Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe.
Topics: Animals; Anthraquinones; Blood Glucose; Boron Compounds; Carbon Tetrachloride; Chemical and Drug Ind | 2019 |
In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe.
Topics: Amino Acid Sequence; Animals; Carbon Tetrachloride; Cell Line, Tumor; Chemical and Drug Induced Live | 2019 |
Zerumbone Protects against Carbon Tetrachloride (CCl
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2019 |
In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Chemical and Drug Indu | 2019 |
Ketoconazole pretreatment ameliorates carbon tetrachloride-induced acute liver injury in rats by suppressing inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2019 |
Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice.
Topics: Animals; Benzaldehydes; Biological Availability; Carbon Tetrachloride; Catalase; Chemical and Drug I | 2019 |
Phase-contrast computed tomography: A correlation study between portal pressure and three dimensional microvasculature of ex vivo liver samples from carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computed Tomography Angiograp | 2019 |
In vivo hepatoprotective and In vitro radical scavenging activities of Cucumis ficifolius A. rich root extract.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cucumis; | 2019 |
Antioxidant Properties of Solenostemma argel Effervescent Tablets.
Topics: Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Li | 2019 |
Hepatoprotective effect of ketoconazole in chronic liver injury model.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Death; Chemical and Drug Induced Liver Injury; Disease M | 2019 |
The ameliorations of Ganoderma applanatum residue polysaccharides against CCl
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fungal Polysacc | 2019 |
Effect of Camellia sinensis, Hypericum perforatum and Urtica dioica on kidney and liver injury induced by carbon tetrachloride in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Camellia sinensis; Carbon Tetrachloride; Catalase; Chemi | 2019 |
Resolution of Murine Toxic Hepatic Injury Quantified With Ultrasound Entropy Metrics.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Entro | 2019 |
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug | 2019 |
The Matrine Derivate MASM Inhibits Recruitment of Gr1hi Monocyte and Alleviates Liver Injury.
Topics: Alkaloids; Animals; Anthracenes; Anti-Inflammatory Agents; Antigens, Ly; Carbon Tetrachloride; Chemi | 2019 |
MSC-triggered metabolomic alterations in liver-resident immune cells isolated from CCl
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Tetrachloride; Cell Separation; Cells, Cultured; Chem | 2019 |
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2019 |
Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury.
Topics: Animals; Anti-Inflammatory Agents; Bile Ducts; Carbon Tetrachloride; Cell Communication; Chemical an | 2019 |
Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Flavano | 2019 |
Hepatoprotective effects of a traditional Chinese medicine formula against carbon tetrachloride-induced hepatotoxicity in vivo and in vitro.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2019 |
Repeated versus single transplantation of mesenchymal stem cells in carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Extracellula | 2013 |
Accumulation of xenotransplanted canine bone marrow cells in NOD/SCID/γc(null) mice with acute hepatitis induced by CCl4.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2013 |
Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Survival; Che | 2013 |
Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat: a novel study.
Topics: Amylases; Animals; Antioxidants; Asteraceae; Blood Glucose; Carbon Tetrachloride; Chemical and Drug | 2015 |
Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
Topics: Acetone; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis | 2013 |
Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies.
Topics: Abelmoschus; Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Chemical and Drug Induce | 2013 |
The protective effect of silymarin on the carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio).
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carps; Chemical and Drug Induced Liver Injury; Humans; | 2013 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
The protective effects of n-acetylcysteine against acute hepatotoxicity.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Ch | 2013 |
[Improvement of carbon tetrachloride drug-induced liver injury model in vitro].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced L | 2012 |
Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blotting, Western; Body Weight | 2013 |
Marrow-derived mesenchymal stem cells restore biochemical markers of acute liver injury in experimental model.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Bone M | 2013 |
Hepatoprotective potential of new steroid against carbon tetrachloride-induced hepatic injury.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Biomark | 2013 |
Wu-Chia-Pi solution attenuates carbon tetrachloride-induced hepatic injury through the antioxidative abilities of its components acteoside and quercetin.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induc | 2012 |
Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; bcl-2-Associated X Protein; bcl-X Protei | 2013 |
Hepatoprotective activity of Hepax-a polyherbal formulation.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Humans | 2011 |
Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Pl | 2011 |
Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Paeonia; | 2013 |
Hepatoprotective role of Abelmoschus esculentus (Linn.) Moench., on carbon tetrachloride-induced liver injury.
Topics: Abelmoschus; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Hep G2 | 2013 |
Hormetic effect of Rosa laevigata Michx in CCl₄-induced hepatotoxicity and the presumptive role of PPARs.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Male; Rosa | 2013 |
Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4 -injured rat liver model via increased autophagic mechanism.
Topics: Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cell Differentiation; Cell Growth Processes; Ch | 2013 |
Response to: "Hormetic effect of Rosa laevigata Michx in CCl₄-induced hepatotoxicity and the presumptive role of PPARs".
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonoids; Male; Rosa | 2013 |
Protective effect of Sida cordata leaf extract against CCl(4) induced acute liver toxicity in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Femal | 2013 |
Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Dose- | 2013 |
Extraction, characterization and biological activities of polysaccharides from Amomum villosum.
Topics: Alanine Transaminase; Amomum; Animals; Antineoplastic Agents; Antioxidants; Aspartate Aminotransfera | 2013 |
Protective effects of Keemun black tea polysaccharides on acute carbon tetrachloride-caused oxidative hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Chemi | 2013 |
Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cul | 2013 |
In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Enzym | 2013 |
Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model.
Topics: Alkaline Phosphatase; Aloe; Animals; Bilirubin; Blood Proteins; Carbon Tetrachloride; Chemical and D | 2013 |
Lymph flow and contractile activity of mesenteric lymph nodes in rats with toxic hepatitis effects of antioxidants.
Topics: alpha-Tocopherol; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2013 |
Protective effects of the flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2013 |
Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.
Topics: Adult; Aged; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette | 2013 |
Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calorimetry, Differential Scanning; Carb | 2013 |
Association of age-dependent liver injury and fibrosis with immune cell populations.
Topics: Age Factors; Aging; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced L | 2013 |
[Protective effects of polysaccharides from Dendrobium huoshanense on CCl4-induced acute liver injury in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
[Intervention effect of aqueous fractions from Boschniakia rossica on hepatic oxidative stress in mice with liver injury induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 2013 |
Generation of functional hepatocyte-like cells from human pluripotent stem cells in a scalable suspension culture.
Topics: Activins; Albumins; Animals; Biological Transport; Bioreactors; Carbocyanines; Carbon Tetrachloride; | 2013 |
Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glycosaminoglycans; Hepatocyt | 2013 |
Toxicological evaluation of Terminalia paniculata bark extract and its protective effect against CCl4-induced liver injury in rodents.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Caspase 3; Cell Li | 2013 |
Jaggery protects hepatorenal injury induced by acute exposure to carbon tetrachloride in Wistar rats.
Topics: Acute Kidney Injury; Adenosine Triphosphatases; Administration, Oral; Animals; Carbon Tetrachloride; | 2013 |
Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts.
Topics: Alkaloids; Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induce | 2013 |
[Studying of hepatoprotective properties of dry extract from apricot leaves on the model of liver lesion by tetrachloromethane].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injur | 2013 |
Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dise | 2013 |
Role of activin A in carbon tetrachloride-induced acute liver injury.
Topics: Activins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 2013 |
Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2013 |
Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
Topics: Acute Disease; Alanine Transaminase; Animals; Antrodia; Aspartate Aminotransferases; Carbon Tetrachl | 2013 |
Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa Libosch.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Rapid and scalable human stem cell differentiation: now in 3D.
Topics: Animals; Carbon Tetrachloride; Cell Culture Techniques; Cell- and Tissue-Based Therapy; Chemical and | 2013 |
Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride | 2005 |
Enhanced intestinal absorption activity and hepatoprotective effect of herpetrione via preparation of nanosuspensions using pH-dependent dissolving-precipitating/homogenization process.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug | 2013 |
Hepatoprotective action of Orthosiphon diffusus (Benth.) methanol active fraction through antioxidant mechanisms: an in vivo and in vitro evaluation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; | 2013 |
[Protective effect of Tanreqing injection on acute hepatic injury induced by CCl4 in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury.
Topics: Alanine Transaminase; Aldehydes; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransf | 2014 |
Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury.
Topics: Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induc | 2013 |
Characterisation of polysaccharides from green tea of Huangshan Maofeng with antioxidant and hepatoprotective effects.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Camellia sinensis; Carbon | 2013 |
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
The hepatoprotective effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Coumarins; Glutathi | 2013 |
Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Iridoid Glucosides; L | 2013 |
Protective effects of the apigenin-O/C-diglucoside saponarin from Gypsophila trichotoma on carbone tetrachloride-induced hepatotoxicity in vitro/in vivo in rats.
Topics: Animals; Antioxidants; Apigenin; Carbon Tetrachloride; Caryophyllaceae; Chemical and Drug Induced Li | 2014 |
Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoni | 2013 |
Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Tetrachloride; Chemical and Dru | 2013 |
Study of the hepatoprotective effect of Juniperus phoenicea constituents.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; D | 2013 |
Hepatoprotective effect of manganese chloride against CCl4-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorides; Cytoprotection; Do | 2013 |
Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Desi | 2013 |
Protective effects of Ziyang tea polysaccharides on CCl4-induced oxidative liver damage in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Camellia sinensis; Carbon | 2014 |
A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL1; Disease Mode | 2014 |
Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis.
Topics: Animals; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced L | 2013 |
Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antigens, CD; Antigens, Differentiation, Myelom | 2014 |
Structural characterization and antioxidant activity of a low-molecular polysaccharide from Dendrobium huoshanense.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Dendr | 2013 |
Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Chick | 2016 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Model | 2014 |
Antioxidant and hepatoprotective activity of Fagonia schweinfurthii (Hadidi) Hadidi extract in carbon tetrachloride induced hepatotoxicity in HepG2 cell line and rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cell | 2013 |
Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glucose; Immunohistochemistry | 2013 |
Golden berry juice attenuates the severity of hepatorenal injury.
Topics: Alkaloids; Animals; Antioxidants; Beverages; Bilirubin; Biomarkers; Carbon Tetrachloride; Chemical a | 2013 |
Protection of a new heptapeptide from Carapax trionycis against carbon tetrachloride-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animal Shells; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetra | 2013 |
Smooth muscle α actin (Acta2) and myofibroblast function during hepatic wound healing.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cell Proliferation; Chem | 2013 |
'Ashvagandharishta' prepared using yeast consortium from Woodfordia fruticosa flowers exhibit hepatoprotective effect on CCl4 induced liver damage in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catalase; Chemical and Drug Induced L | 2014 |
Protective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver.
Topics: Acetates; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavo | 2016 |
NMR-based metabonomic and quantitative real-time PCR in the profiling of metabolic changes in carbon tetrachloride-induced rat liver injury.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2014 |
Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments.
Topics: Age Factors; Animals; Blotting, Western; Carbon Tetrachloride; CCAAT-Enhancer-Binding Protein-alpha; | 2014 |
Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Dioxole | 2014 |
Study of hepatoprotective effects of xymedon.
Topics: Alanine Transaminase; Animals; Animals, Outbred Strains; Aspartate Aminotransferases; Blood Glucose; | 2013 |
Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Live | 2014 |
The pro-fibrotic effects of pregnancy in a carbon-tetrachloride-induced liver injury in mouse model.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Chemical and Drug I | 2014 |
The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Carnitine; Chemical and Drug Induced Liver Injury; Di | 2013 |
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.
Topics: Animals; Calgranulin A; Calgranulin B; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2014 |
Ex vivo assessment of carbon tetrachloride (CCl(4))-induced chronic injury using polarized light spectroscopy.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2013 |
Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2014 |
Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; | 2014 |
Metabonomics study on the hepatoprotective effect of polysaccharides from different preparations of Angelica sinensis.
Topics: Alanine Transaminase; Angelica sinensis; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Te | 2014 |
Protective effects of quercetin and quercetin-5',8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2013 |
Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis.
Topics: Animals; Biomarkers; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; C | 2014 |
Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2014 |
Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cationic Amino Acid Transporter 1; CCAAT-Enhancer-Binding Protein-alp | 2014 |
Chronological changes in circulating levels of soluble tumor necrosis factor receptors 1 and 2 in rats with carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Chemica | 2014 |
Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial.
Topics: Animals; Biocompatible Materials; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dite | 2015 |
[Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Bilirubin; Carbon Tetrachloride; C | 2013 |
[Protective effect of purple sweet potato flavonoids on CCL4-induced acute liver injury in mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flavo | 2013 |
Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries.
Topics: Acute Disease; Administration, Oral; Animals; Anthocyanins; Antioxidants; Biomarkers; Carbon Tetrach | 2014 |
Antihepatotoxic effect of tadehaginoside, extracted from Tadehagi triquetrum (L.), against CCl4-lesioned rats through activating the Nrf2 signaling pathway and attenuating the inflammatory response.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coumaric Acids; Fabaceae; Gen | 2014 |
Aqueous extract of Gracilaria tenuistipitata suppresses LPS-induced NF-κB and MAPK activation in RAW 264.7 and rat peritoneal macrophages and exerts hepatoprotective effects on carbon tetrachloride-treated rat.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; | 2014 |
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Tetrachloride; Cell Diffe | 2014 |
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug | 2014 |
Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chalcones; Chemical and Drug Induced Liver Injury; Gen | 2014 |
Hepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4 induced hepatic injury in swiss albino mice.
Topics: Amorphophallus; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver | 2014 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Dr | 2014 |
Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and in vitro evaluation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2014 |
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
Topics: Angiotensin II; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; D | 2014 |
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Gene Dele | 2014 |
Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; | 2014 |
Antioxidant and hepatoprotective effects of Solanum xanthocarpum leaf extracts against CCl4-induced liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Plant Ext | 2014 |
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Topics: ADAM Proteins; Alanine Transaminase; Animals; Antibodies, Monoclonal; Antigens, CD; Biomarkers; Carb | 2014 |
Phenolic composition, DNA damage protective activity and hepatoprotective effect of free phenolic extract from Sphallerocarpus gracilis seeds.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Apiaceae; Aspartate Aminotransferases; Carbon T | 2014 |
Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury.
Topics: Animals; Antigens, CD1d; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2014 |
Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Fabac | 2014 |
Protective effect of Actiniopteris radiata (Sw.) Link. against CCl₄ induced oxidative stress in albino rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Gluta | 2014 |
Naringenin attenuates CCl4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavanones; Gene Expression R | 2014 |
Transformation of salvianolic acid B to salvianolic acid a in aqueous solution and the in vitro liver protective effect of the main products.
Topics: Antioxidants; Benzofurans; Biphenyl Compounds; Caffeic Acids; Carbon Tetrachloride; Cell Line; Chemi | 2014 |
Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol 7-a | 2014 |
The biliary epithelium gives rise to liver progenitor cells.
Topics: Acetaminophen; Animals; Bile Ducts; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, | 2014 |
Structural characterisation of algae Costaria costata fucoidan and its effects on CCl₄-induced liver injury.
Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Hydroxyl Radical; Phae | 2014 |
Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats.
Topics: Animals; Azadirachta; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Limonins | 2014 |
Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, | 2014 |
Hepatoprotective and antioxidant activities of Hepacare®, a herbal formulation against carbon tetrachloride-induced liver injury.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response R | 2015 |
Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2014 |
High-mobility group box 1 exacerbates CCl₄-induced acute liver injury in mice.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Carbon Tetrachloride; Chemical and Drug Induc | 2014 |
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2014 |
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Carbon Tetrachloride; Cell Death; Chemical an | 2014 |
R2* and R2 mapping for quantifying recruitment of superparamagnetic iron oxide-tagged endothelial progenitor cells to injured liver: tracking in vitro and in vivo.
Topics: Animals; Carbon Tetrachloride; Cell Tracking; Chemical and Drug Induced Liver Injury; Contrast Media | 2014 |
Effects of fish oil on cell proliferation and liver injury in an experimental model of acute hepatic injury induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injur | 2014 |
Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachl | 2014 |
Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-κB, and pro-fibrotic factor TGF-β1 mediating inflammatory signaling.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation | 2016 |
Determination of DNA damage in experimental liver intoxication and role of N-acetyl cysteine.
Topics: Acetylation; Acetylcysteine; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2014 |
Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2014 |
The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation; Liver; Liver | 2014 |
Antioxidant and hepatoprotective activity of Veronica ciliata Fisch. extracts against carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Mice; Pla | 2014 |
Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2014 |
Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Chemical and Dr | 2014 |
The effects of grape seed and colchicine on carbon tetrachloride induced hepatic damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Colchicine; Dis | 2014 |
The protective effect of Phoenix dactylifera L. seeds against CCl4-induced hepatotoxicity in rats.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2014 |
Hepatoprotective and antioxidant effect of Bauhinia hookeri extract against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive compounds by HPLC-PDA-ESI-MS/MS.
Topics: Animals; Antioxidants; Bauhinia; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2014 |
The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2014 |
Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice.
Topics: Animals; Antioxidants; Body Weight; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver | 2014 |
Hepatoprotective effects of Mimic of Manganese superoxide dismutase against carbon tetrachloride-induced hepatic injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomimetic Materials; Biphenyl Compounds | 2014 |
Protective effects of Baccharis dracunculifolia leaves extract against carbon tetrachloride- and acetaminophen-induced hepatotoxicity in experimental animals.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Baccharis; Carbon Tetrachloride; Chemical and Drug | 2014 |
Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Betaine; Carbon Tetrachlor | 2014 |
Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Lipid P | 2014 |
Hepatoprotective effect of superfine particles of herbal medicine against CCl4-induced acute liver damage in rats.
Topics: Acute Disease; Animals; Antioxidants; bcl-2-Associated X Protein; Biomarkers; Carbon Tetrachloride; | 2014 |
Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Iodide P | 2014 |
Effect of leaf extracts of Taraxacum officinale on CCl4 induced hepatotoxicity in rats, in vivo study.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Phytotherapy; Pl | 2014 |
Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ferns; Liver; | 2014 |
Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Kupffer Cells; Liver; MAP Kin | 2014 |
Fatty acid binding protein 7 regulates phagocytosis and cytokine production in Kupffer cells during liver injury.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; | 2014 |
[Protection and bidirectional effect of rhubarb anthraquinone and tannins for rats' liver].
Topics: Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2014 |
Hepatoprotective activity of Gentiana veitchiorum Hemsl. against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2014 |
Phosphate-dependent glutaminase response to liver injury and hyperbaric oxygenation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Glutaminase; Hepatect | 2014 |
Origin of myofibroblasts in the fibrotic liver in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen Type I; | 2014 |
Protective effect of Aframomum melegueta phenolics against CCl₄-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; C | 2014 |
[Metabonomic study on protective effect of xiaoyao powder for acute hepatic injury in rats].
Topics: Amino Acids; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2014 |
Characterization of polysaccharides with antioxidant and hepatoprotective activities from the wild edible mushroom Russula vinosa Lindblad.
Topics: Agaricales; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrach | 2014 |
Potential protection of vitamin C against liver-lesioned mice.
Topics: Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2014 |
Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl₄-treated rats.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatic | 2015 |
Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Hep G2 | 2015 |
Icaritin ameliorates carbon tetrachloride-induced acute liver injury mainly because of the antioxidative function through estrogen-like effects.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Chemica | 2014 |
Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts.
Topics: Abrus; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Carrageenan; Chemical an | 2014 |
Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induced Liver Injury; G | 2014 |
Effect of apitherapy formulations against carbon tetrachloride-induced toxicity in Wistar rats after three weeks of treatment.
Topics: Administration, Oral; Animals; Apitherapy; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Antioxidative and chemopreventive effects of Nephrolepis biserrata against carbon tetrachloride (CCl4)-induced oxidative stress and hepatic dysfunction in rats.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2015 |
Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, H | 2014 |
Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp.
Topics: Animals; Antioxidants; Basic-Leucine Zipper Transcription Factors; Carbon Tetrachloride; Chemical an | 2014 |
Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Bixaceae; Carbon Tetrachloride; Carotenoids; Chemical and Drug Induced Liver | 2014 |
Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corn Oil; | 2014 |
Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Carbon Tetrachloride; Caspase 3; Caspase 9; | 2014 |
Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions.
Topics: Andrographis; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; C | 2014 |
Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice.
Topics: Animals; Antioxidants; Biflavonoids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; C | 2014 |
Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats.
Topics: Animals; Bone Morphogenetic Protein 7; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2014 |
β-sitosterol protects against carbon tetrachloride hepatotoxicity but not gentamicin nephrotoxicity in rats via the induction of mitochondrial glutathione redox cycling.
Topics: Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Live | 2014 |
Hepatoprotective effect of the aqueous extract of Simarouba amara Aublet (Simaroubaceae) stem bark against carbon tetrachloride (CCl4)-induced hepatic damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Plant Bark; Plan | 2014 |
Antioxidant activity in vitro and hepatoprotective effect of Phlomis maximowiczii in vivo.
Topics: Alanine Transaminase; Aldehydes; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachl | 2014 |
Antioxidant activities in vitro and hepatoprotective effects of Nelumbo nucifera leaves in vivo.
Topics: Alanine Transaminase; Aldehydes; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachl | 2014 |
In vitro antioxidant and in vivo hepatoprotective activity of leave extract of Raphanus sativus in rats using CCL4 model.
Topics: Alanine Transaminase; Aldehydes; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachl | 2014 |
Comparative anti-inflammatory and hepatoprotective activities of Astragalus gummifer Labill herb and roots in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Astragalus gum | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
The protective effect of Esculentoside A on experimental acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2014 |
Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis.
Topics: Actins; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetr | 2014 |
Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzodioxoles; Car | 2016 |
CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DNA Damage | 2014 |
Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclin A; Cyclin D1; Epiderma | 2015 |
Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice.
Topics: Angelica; Animals; Astragalus Plant; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; F | 2015 |
Differences in antioxidant activities of outdoor- and indoor-cultivated Agaricus brasiliensis, and protective effects against carbon tetrachloride-induced acute hepatic injury in mice.
Topics: Agaricus; Agriculture; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bio | 2014 |
Hepatoprotective effect of ethanol extract from Berchemia lineate against CCl4-induced acute hepatotoxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2015 |
Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; | 2015 |
Hepatoprotective properties of aqueous leaf extract of Persea Americana, Mill (Lauraceae) 'avocado' against CCL4-induced damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2014 |
NF-κB activation and proinflammatory cytokines mediated protective effect of Indigofera caerulea Roxb. on CCl4 induced liver damage in rats.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2014 |
Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Buthionine Sulfoximine; Carbon Tetrachlo | 2015 |
Green tea extract supplementation depresses carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Mice; Oxidative Stress; Phyto | 2014 |
Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; DNA-Bindi | 2015 |
Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl₄-induced injury.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Complemen | 2015 |
Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2014 |
Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2015 |
Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.
Topics: Animals; Aryldialkylphosphatase; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2014 |
Differential protective effects of polyphenol extracts from apple peels and fleshes against acute CCl₄-induced liver damage in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Body | 2015 |
Protective effect of aqueous extracts from Rhizopus oryzae on liver injury induced by carbon tetrachloride in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromodeoxyuridine; | 2015 |
Portal blood arterialization with an extracorporeal device to treat toxic acute hepatic failure in a swine model.
Topics: Animals; Biomarkers; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease M | 2014 |
Pharmacological Potential of Tetrahydrofurano/Pyrano Quinoline and Benzo[b]furoindolyl Derivatives in Acute Inflammation, Pain and Oxidative Stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzofurans; Carbon Tetrachloride; Carr | 2015 |
Systemic treatment of acute liver failure with adipose derived stem cells.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Ce | 2015 |
[Hepatorotective activity of honeysuckle fruit extract in carbon tetrachloride intoxicated rats].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fruit; | 2014 |
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Caspase 12; Caspase 3; Caspase 9; Chemical and | 2014 |
Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity.
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induc | 2015 |
Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Female; Liver; Olean | 2015 |
Humic acid and glucan: protection against liver injury induced by carbon tetrachloride.
Topics: Animals; Aspartate Aminotransferases; beta-Glucans; Camellia sinensis; Carbon Tetrachloride; Chemica | 2015 |
Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cult | 2015 |
Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromosomes; Diet, High-Fat; | 2015 |
Hepatoprotective and antioxidant effects of wheat, carrot, and mango as nutraceutical agents against CCl4-induced hepatocellular toxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Daucus carota; | 2015 |
Evaluation of the effectiveness of Piper cubeba extract in the amelioration of CCl4-induced liver injuries and oxidative damage in the rodent model.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2015 |
Hepatoprotective effects of lignans extract from Herpetospermum caudigerum against CCl₄-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2015 |
Two-signal requirement for growth-promoting function of Yap in hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Carbon Tetrachloride; Cell Cycle P | 2015 |
Therapeutic efficacy of Nigella sativa Linn. seed extract against CCl4 induced hepatic injury in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2015 |
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2015 |
Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Methanol; Plant Extract | 2015 |
Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Alisma; Animals; Apoptosis; Aspartate Aminotransferases; ATP Binding Cassette | 2015 |
Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC/MS Q-TOF.
Topics: Animals; Biomarkers; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chro | 2015 |
Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl4-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2015 |
Caffeic acid phenethyl ester inhibits liver fibrosis in rats.
Topics: Alcohol Drinking; Animals; Antioxidants; Biomarkers; Caffeic Acids; Carbon Tetrachloride; Chemical a | 2015 |
Optical diagnosis of the progression and reversal of CCl4-induced liver injury in rodent model using minimally invasive autofluorescence spectroscopy.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disea | 2015 |
Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota).
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induc | 2015 |
Cytotoxicity and hepatoprotective attributes of methanolic extract of Rumex vesicarius L.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Antioxidants; Aspartat | 2015 |
Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Carbon Tetrachloride; CD11b Antigen; Chemical and Drug Induced Liver Injury; Disease Models | 2015 |
Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Cell Survival; Chemical and Drug Induced Live | 2015 |
Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2015 |
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 2015 |
Protective effect of Terminalia muelleri against carbon tetrachloride-induced hepato and nephro-toxicity in mice and characterization of its bioactive constituents.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response R | 2016 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Contrast-enhanced ultrasound for quantitative assessment of portal pressure in canine liver fibrosis.
Topics: Animals; Area Under Curve; Biopsy; Blood Flow Velocity; Blood Pressure Determination; Carbon Tetrach | 2015 |
Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2015 |
Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Pri | 2015 |
Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Dependovirus; Extr | 2015 |
Sesamol loaded solid lipid nanoparticles: a promising intervention for control of carbon tetrachloride induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzodioxoles; Carbon Tetr | 2015 |
[Protective effects and possible mechanisms of hepatic fibrosis against APAP-induced lethal injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus.
Topics: Acacia; Animals; Antioxidants; Antiviral Agents; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2015 |
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Caspase 3; Chemical an | 2015 |
Deceleration of liver regeneration by knockdown of augmenter of liver regeneration gene is associated with impairment of mitochondrial DNA synthesis in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
A biochemical and immunohistochemical study of the protective effects of carnosine for carbon tetrachloride induced liver injury in rats.
Topics: Albinism; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carnosine; Ch | 2015 |
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Topics: Animals; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Free Radical Scave | 2015 |
Carbon tetrachloride-induced liver injury in mice is tissue factor dependent.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA, | 2015 |
Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Proliferation; | 2015 |
Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Caspase Inhibitors; Cell Prolif | 2015 |
Carbon tetrachloride-induced hepatic and renal damages in rat: inhibitory effects of cacao polyphenol.
Topics: Acute Kidney Injury; Animals; Antioxidants; Cacao; Carbon Tetrachloride; Chemical and Drug Induced L | 2015 |
Effects of polysaccharides from selenium-enriched Pyracantha fortuneana on mice liver injury.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease M | 2015 |
Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; bcl-X Protein; Biomarkers; Carbon Tetrac | 2015 |
Parboiled Germinated Brown Rice Protects Against CCl4-Induced Oxidative Stress and Liver Injury in Rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; DNA Damage; Germina | 2016 |
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Antigens, CD; Antigens, Neoplasm; Becaplermin; Carbon | 2016 |
Protective effect and antioxidant role of sweetgum (Liquidambar orientalis) oil against carbon tetrachloride-induced hepatotoxicity and oxidative stress in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipid Peroxidat | 2016 |
Lipid Peroxidation-Antioxidant Defense System during Toxic Liver Damage and Its Correction with a Nanocomposite [corrected] Substance Containing Selenium and Arabinogalactan.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactans; Lipi | 2015 |
Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hep G2 Cells; H | 2016 |
Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytopro | 2015 |
[Effects of 4-phenylbutyric acid on carbon tetrachloride-induced acute liver injury in mice].
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2015 |
Effects of Pistacia Atlantica Extract on Erythrocyte Membrane Rigidity, Oxidative Stress, and Hepatotoxicity Induced by CCl4 in Rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Disea | 2015 |
The influence of the Xymedon preparation (Hydroxyethyldimethyldihydropyrimidine) on the rat liver recovery under toxic damage induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Compounding; Female; Liv | 2015 |
Hepatoprotective effects of Micromeria croatica ethanolic extract against CCl4-induced liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lamiaceae; Liver; Male; Mice; | 2015 |
Anti-fibrotic effects of the Masson pine pollen aqueous extract on hepatic fibrosis rat model.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2015 |
Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dioxoles; Disea | 2015 |
Human Adipose-Derived Mesenchymal Stem Cells Promote Liver Regeneration.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2015 |
Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Topics: Acetylation; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbamates; Carbon Tetrachloride; Ce | 2015 |
Quercetin protects mouse liver against CCl₄-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrach | 2015 |
Preventive effects of the polysaccharide of Larimichthys crocea swim bladder on carbon tetrachloride (CCl4)-induced hepatic damage.
Topics: Animal Structures; Animals; Biological Products; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 2015 |
Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4‑induced fibrosis in mice.
Topics: Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2015 |
SHSST-cyclodextrin complex inhibits TGF-β/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Connective Tissue Growth Fact | 2015 |
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, | 2015 |
Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner.
Topics: Adult; Aged; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Mov | 2015 |
Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cichorium intybus; Female; Fl | 2015 |
Antioxidant and hepatoprotective effects of mixed micellar lipid formulation of phyllanthin and piperine in carbon tetrachloride-induced liver injury in rodents.
Topics: Administration, Oral; Alkaloids; Animals; Antioxidants; Benzodioxoles; Carbon Tetrachloride; Chemica | 2015 |
Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla.
Topics: Adult; Amides; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Feasibility St | 2016 |
Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2015 |
N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced L | 2015 |
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Carbon Te | 2016 |
Antioxidative Activity of Platinum Nanocolloid and Its Protective Effect Against Chemical-Induced Hepatic Cellular Damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Colloids; Cytop | 2015 |
Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice.
Topics: Animals; Bauhinia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Hig | 2015 |
Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2015 |
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; | 2015 |
Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2016 |
Hepatoprotective effects of polysaccharide isolated from Agaricus bisporus industrial wastewater against CCl₄-induced hepatic injury in mice.
Topics: Agaricus; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 2016 |
Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-(13)C]pyruvate.
Topics: Alanine; Animals; Carbon Tetrachloride; Carbon-13 Magnetic Resonance Spectroscopy; Chemical and Drug | 2015 |
Transplantation of human adipose stem cell-derived hepatocyte-like cells with restricted localization to liver using acellular amniotic membrane.
Topics: Adipocytes; Amnion; Animals; Antigens, Differentiation; Carbon Tetrachloride; Cells, Cultured; Chemi | 2015 |
Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocyti | 2015 |
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2016 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2015 |
Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2015 |
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Carbon Tetrachloride; Case-Control Studies; C | 2016 |
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice.
Topics: Age Factors; Aging; Animals; Carbon Tetrachloride; Cell Movement; Cells, Cultured; Chemical and Drug | 2016 |
Hepatoprotective and antioxidant effect of ellagitannins and galloyl esters isolated from Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in HepG2 cells.
Topics: Alanine Transaminase; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; C | 2016 |
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2015 |
Resveratrol can prevent CCl₄-induced liver injury by inhibiting Notch signaling pathway.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dise | 2016 |
Antioxidant and Hepatoprotective Activities of Mycelia Selenium Polysaccharide by Hypsizigus marmoreus SK-02.
Topics: Agaricales; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liv | 2016 |
Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice.
Topics: Animals; Antigens, Ly; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; | 2016 |
D-Pinitol Protects Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2015 |
Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate.
Topics: Alanine Transaminase; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2016 |
A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs.
Topics: Acetaminophen; Animals; Atorvastatin; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Li | 2016 |
MiR-17~92 ablation impairs liver regeneration in an estrogen-dependent manner.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclin-De | 2016 |
Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Cell Line; Chemical and Drug Induced Li | 2016 |
The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2016 |
Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Catechols; Chemic | 2016 |
Protective effect of a polysaccharide from Rhizoma Atractylodis Macrocephalae on acute liver injury in mice.
Topics: Animals; Antioxidants; Atractylodes; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Li | 2016 |
Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2016 |
Group IVA phospholipase A(2) deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.
Topics: Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Live | 2016 |
Protective Effects of Extract from Sclerotium of the King Tuber Medicinal Mushroom, Pleurotus tuberregium (Higher Basidiomycetes) on Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Albino Rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Nigeria; Pleurotus; Pr | 2015 |
Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation.
Topics: Administration, Oral; Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical | 2016 |
Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway.
Topics: Adenoviridae; Animals; beta Catenin; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induce | 2016 |
Protective effects of Chaenomeles thibetica extract against carbon tetrachloride-induced damage via the MAPK/Nrf2 pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2016 |
Protective Effect of Gallotannin-Enriched Extract Isolated from Galla Rhois against CCl₄-Induced Hepatotoxicity in ICR Mice.
Topics: Animals; Antioxidants; Aphids; Apoptosis; Apoptosis Regulatory Proteins; Biological Products; Biomar | 2016 |
Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2016 |
Protective effect of wedelolactone against CCl4-induced acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; C | 2016 |
Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; C | 2016 |
Telmisartan ameliorates carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Carbon Te | 2017 |
Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study.
Topics: alpha-Macroglobulins; Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injur | 2016 |
Intact Endogenous Metabolite Analysis of Mice Liver by Probe Electrospray Ionization/Triple Quadrupole Tandem Mass Spectrometry and Its Preliminary Application to in Vivo Real-Time Analysis.
Topics: Amino Acids; Animals; Carbohydrates; Carbon Tetrachloride; Carboxylic Acids; Chemical and Drug Induc | 2016 |
Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2016 |
New mechanism in the modulation of carbon tetrachloride hepatotoxicity in rats using different natural antioxidants.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Drug | 2016 |
Expansion and Hepatic Differentiation of Adult Blood-Derived CD34+ Progenitor Cells and Promotion of Liver Regeneration After Acute Injury.
Topics: Animals; Antigens, CD34; Carbon Tetrachloride; Cell Differentiation; Chemical and Drug Induced Liver | 2016 |
Effect of Microenvironment on Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Hepatocytes In Vitro and In Vivo.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Chemical and Drug Induced Liver Inj | 2016 |
BLOOD CHOLINESTERASE ACTIVITIES AFTER MALATHION POISONING IN LIVER INJURY.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholinesterases; Insecticides | 1999 |
Protective effects of L-carnosine on CCl4 -induced hepatic injury in rats.
Topics: Actins; Animals; Biomarkers; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury | 2016 |
Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin.
Topics: Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; China; Chrom | 2016 |
Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function.
Topics: Alloxan; Animals; Blood Glucose; Carbamates; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2016 |
Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways.
Topics: Alanine Transaminase; Alkaloids; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; | 2016 |
Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycl | 2016 |
Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chalcone; Chemical and Drug Induced Liver Injury; Femal | 2016 |
Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.
Topics: Action Potentials; Animals; Carbon Tetrachloride; Cardiomyopathies; Cardiotonic Agents; Chemical and | 2016 |
Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical an | 2016 |
San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Animals; beta-Cyclodextrins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Syne | 2016 |
Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium-Binding Pr | 2016 |
Antifibrotic effect of meloxicam in rat liver: role of nuclear factor kappa B, proinflammatory cytokines, and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2016 |
Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats.
Topics: Acetates; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoc | 2016 |
Effects of platelet-rich plasma on liver regeneration in CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Connective Tissue; Disease Mo | 2016 |
Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Conne | 2016 |
Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury.
Topics: Animals; Autocrine Communication; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2016 |
Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride-mediated oxidative hepatocellular damage in rat model.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curc | 2016 |
Effects of Rhus tripartitum fruit extract on CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cisplati | 2016 |
Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.
Topics: Animals; Carbon Tetrachloride; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; G | 2016 |
The immature rat as a potential model for chemical risks to children: Ontogeny of selected hepatic P450s.
Topics: Activation, Metabolic; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Ch | 2016 |
Corosolic acid suppresses the expression of inflammatory marker genes in CCL4-induced-hepatotoxic rats.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Int | 2016 |
Serum metabonomics study of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced acute hepatotoxicity in rats by (1)H NMR analysis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corydalis; Magnetic Resonance | 2016 |
Pharmacological safety evaluation of a traditional herbal medicine "Zereshk-e-Saghir" and assessment of its hepatoprotective effects on carbon tetrachloride induced hepatic damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Berb | 2016 |
Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug | 2016 |
Beneficial Effects of Silymarin After the Discontinuation of CCl4-Induced Liver Fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2016 |
Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Gene E | 2016 |
Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; L | 2016 |
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules, Neuronal; Chemical and Drug Induced Liver In | 2016 |
Phytochemical, antioxidant and hepatoprotective effects of Alnus nitida bark in carbon tetrachloride challenged Sprague Dawley rats.
Topics: Alnus; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromato | 2016 |
Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
Topics: Aldehyde Reductase; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Carbon Tetrachloride; Chemical | 2016 |
Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Carbon Tetrachloride; Cell Survival; C | 2016 |
Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Gluta | 2016 |
Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcuma; Curcumin; Glutathion | 2016 |
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Topics: Acetaminophen; Adult; Aged; Animals; Biomarkers; Blood Chemical Analysis; Carbon Tetrachloride; Chem | 2016 |
Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.
Topics: Animals; Autophagy; Carbon Tetrachloride; Caspase 9; Chemical and Drug Induced Liver Injury; Female; | 2016 |
Suppressive Effect of Kampo Formula "Juzen-taiho-to" on Carbon Tetrachloride-Induced Hepatotoxicity in Mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Calcium; Carbon Tetrachlor | 2016 |
Cornigerin, a new sesqui-lignan from the hepatoprotective fractions of Cynara cornigera L.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Fractionation; Cynar | 2016 |
Protective effects of seed melon extract on CCl
Topics: Actins; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2016 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepat | 2016 |
Preventative Effect of Vitamin E on Mast Cells in Carbon Tetrachlorideinduced Acute Liver Damage.
Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2016 |
The hepatoprotective activity of olive oil and Nigella sativa oil against CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipids; Male; Nigella sativa; | 2016 |
Methanol extract of Nymphaea lotus ameliorates carbon tetrachloride-induced chronic liver injury in rats via inhibition of oxidative stress.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Methanol; Nymphaea; Oxi | 2017 |
Cystathionine γ-Lyase Deficiency Exacerbates CCl
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2017 |
Essential Oils from Thyme (Thymus vulgaris): Chemical Composition and Biological Effects in Mouse Model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemotaxis; Cytokines; Edema; | 2016 |
Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
Topics: Alcohol Oxidoreductases; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced | 2017 |
Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrach | 2017 |
The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill.
Topics: Administration, Oral; Alanine Transaminase; Animals; Biomarkers; Body Weight; Carbon Tetrachloride; | 2017 |
Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil.
Topics: Allyl Compounds; Animals; Antioxidants; Brain; Brassica; Carbon Tetrachloride; Chemical and Drug Ind | 2017 |
Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice.
Topics: Animals; Autophagy; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2017 |
The antioxidative and hepatoprotective effects comparison of Chinese angelica polysaccharide(CAP)and selenizing CAP (sCAP) in CCl
Topics: Angelica sinensis; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2017 |
Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Ascorbic Ac | 2017 |
Transdifferentiation of human male germline stem cells to hepatocytes in vivo via the transplantation under renal capsules.
Topics: Albumins; alpha 1-Antitrypsin; Animals; Blotting, Western; Carbon Tetrachloride; Cell Transdifferent | 2017 |
Hepatoprotective standardized EtOH-water extract of the leaves of Ziziphus jujuba.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Mice; Pl | 2017 |
Inulin-type fructan and infusion of Artemisia vulgaris protect the liver against carbon tetrachloride-induced liver injury.
Topics: Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fruc | 2017 |
Ciliary neurotrophic factor analogue aggravates CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ciliary Neurotrophic Factor; | 2017 |
Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway.
Topics: Animals; Antioxidant Response Elements; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and | 2017 |
Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Mice; Orc | 2017 |
C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice.
Topics: Adaptation, Physiological; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Li | 2017 |
Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astragalus propinquus; Carbon Tetr | 2017 |
Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coreopsis; Cytokines; Flowers | 2017 |
Metron factor-1 prevents liver injury without promoting tumor growth and metastasis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells | 2008 |
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type IV; | 2008 |
Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2008 |
Saengshik, a formulated health food, prevents liver damage in CCl4-induced mice and increases antioxidant activity in elderly women.
Topics: Agaricales; Aged; Aging; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Live | 2008 |
Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug In | 2008 |
Hepatic protection by noni fruit juice against CCl(4)-induced chronic liver damage in female SD rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation.
Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Caspases | 2008 |
Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Dose- | 2008 |
Hepatoprotective activity of Amaranthus spinosus in experimental animals.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amaranthus; Animals; Aspartate Aminotransferases; Biliru | 2008 |
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Am | 1981 |
Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation.
Topics: Animals; Antioxidants; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Live | 2009 |
Quantitative rat liver function test by galactose single point method.
Topics: Alanine Transaminase; Animals; Animals, Laboratory; Aspartate Aminotransferases; Carbon Tetrachlorid | 2008 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Hepatoprotective effect of Hibiscus hispidissimus Griffith, ethanolic extract in paracetamol and CCl4 induced hepatotoxicity in Wistar rats.
Topics: Acetaminophen; Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2008 |
Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; D | 2009 |
Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Choleretic activity of 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol on the model of CCl4-induced hepatitis.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholagogues and Cholere | 2008 |
The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat.
Topics: Acetates; Alanine Transaminase; Animals; Bilirubin; Carbon Tetrachloride; Catalase; Chemical and Dru | 2009 |
Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and | 2008 |
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Prolifer | 2009 |
Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Glutathi | 2009 |
Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cloning, Molecular; Free Radi | 2008 |
Prevention of CCl4-induced liver damage by ginger, garlic and vitamin E.
Topics: Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Garlic; | 2007 |
Hepatoprotective effects of Artemisiae capillaris herba and Picrorrhiza rhizoma combinations on carbon tetrachloride-induced subacute liver damage in rats.
Topics: Alanine Transaminase; Animals; Artemisia; Aspartate Aminotransferases; Body Weight; Carbon Tetrachlo | 2008 |
Effects of the extracts of Pycanthus angolensis against chemically induced acute hepatotoxicity.
Topics: Alkaloids; Animals; Antioxidants; Bile Acids and Salts; Carbon Tetrachloride; Carbon Tetrachloride P | 2007 |
An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 2009 |
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols.
Topics: Animals; Apolipoproteins E; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine | 2009 |
Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Chemical and Drug Induced Liver Injury; DNA Pri | 2009 |
Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease.
Topics: Animals; Aryldialkylphosphatase; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemo | 2009 |
Hepatoprotective properties of fractions from meadowsweet extract during experimental toxic hepatitis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Filipendula; Live | 2008 |
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosylceramides; Hepatic | 2009 |
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cell Movement; Cell Proliferation; Cells, Cultured | 2009 |
Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Dose-Response Relationsh | 2009 |
Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats.
Topics: Animals; Animals, Suckling; Blood Chemical Analysis; Blotting, Western; Carbon Tetrachloride; Carbon | 2009 |
Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aryldialkylphosphatase; Aspartate Aminotransferases; Carbon Tetrachlo | 2009 |
Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats.
Topics: Animals; Astragalus propinquus; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chroni | 2009 |
Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cassia; Chemical and Drug Induced Liver Injury; Glutath | 2009 |
Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Mice; | 2009 |
A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Carboxypeptidase B2; Cell Division; Cells, Cultured; C | 2009 |
Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced L | 2009 |
The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Differentiati | 2009 |
Hepato and reno protective action of Calendula officinalis L. flower extract.
Topics: Acute Disease; Animals; Antioxidants; Calendula; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2009 |
Hepatoprotective and curative properties of Kombucha tea against carbon tetrachloride-induced toxicity.
Topics: Acetobacter; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbo | 2009 |
Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coculture | 2009 |
Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 2009 |
Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.
Topics: Acute Disease; Animals; Axl Receptor Tyrosine Kinase; Carbon Tetrachloride; Cell Proliferation; Chem | 2009 |
Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.
Topics: Animals; Carbon Tetrachloride; cdc42 GTP-Binding Protein; Cell Proliferation; Chemical and Drug Indu | 2009 |
Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure.
Topics: Animals; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene Expression Profi | 2009 |
Thyroid modulation of TNF-dependent apoptosis and formation of chronic liver disease in endogenous intoxication in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Female; | 2009 |
Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; Chemica | 2009 |
Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Annonaceae; Aspartate | 2009 |
Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Injury; | 2009 |
Radical scavenging abilities and hepatoprotective effect of [N, N'-Bis (salicylidene) ethane-1, 2-diaminato] oxovanadium (IV) complex in CCl4-treated rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Free | 2010 |
Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Carbon Tetra | 2009 |
Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.
Topics: Abietanes; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose | 2009 |
Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Asteraceae; Blood Proteins; Carbon Tetra | 2009 |
Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Adhesion; Cell Differen | 2009 |
Protective effect of Millettia reticulata Benth against CCl(4)-induced hepatic damage and inflammatory action in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2009 |
Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride-induced hepatic injury in the Hanover Wistar rat.
Topics: Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 2009 |
Hepatoprotective effect of Carissa carandas Linn root extract against CCl4 and paracetamol induced hepatic oxidative stress.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Apocynaceae; Aspartate Aminotransferases; Carbo | 2009 |
Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disaccharides; | 2009 |
Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Mode | 2009 |
Bioactive microbial metabolites from glycyrrhetinic acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Biotransformation; Carbon Tetrachloride; Chemical and Drug Ind | 2010 |
Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2011 |
Antioxidant and antigenotoxic activities of purple grape juice--organic and conventional--in adult rats.
Topics: Animals; Antimutagenic Agents; Antioxidants; Beverages; Brain; Carbon Tetrachloride; Catalase; Catec | 2009 |
Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats.
Topics: Animals; Antioxidants; Berberine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzy | 2010 |
Rubus sanctus protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachlori | 2009 |
Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride.
Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 2009 |
Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyperaceae; Plant Extracts; R | 2010 |
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2010 |
In vitro antioxidant and in vivo prophylactic effects of two gamma-lactones isolated from Grewia tiliaefolia against hepatotoxicity in carbon tetrachloride intoxicated rats.
Topics: Animals; Antioxidants; Biomarkers; Caproates; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2010 |
Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood; Carbon Tetr | 2010 |
Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Regulation; | 2010 |
Comparative evaluation of the protective potentials of human paraoxonase 1 and 3 against CCl4-induced liver injury.
Topics: Adenoviridae; Animals; Apoptosis; Aryldialkylphosphatase; Carbon Tetrachloride; Chemical and Drug In | 2010 |
Taohe Chengqi Tang ameliorates acute liver injury induced by carbon tetrachloride in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2010 |
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Topics: Adenovirus E1A Proteins; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Cycle; Cell | 2010 |
Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity.
Topics: Analysis of Variance; Animals; Biomarkers; Blood Glucose; Carbon Tetrachloride; Carbon Tetrachloride | 2010 |
[Evaluation of antioxidant and hepatoprotective properties of strain Lactobacillus casei 114001 in carbon tetrachloride-induced liver toxicity model].
Topics: Alanine Transaminase; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride | 2009 |
Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats.
Topics: Animals; Antioxidants; Bilirubin; Biomarkers; Brassicaceae; Carbon Tetrachloride; Carbon Tetrachlori | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
Predose blood gene expression profiles might identify the individuals susceptible to carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene Expression; Gene Express | 2010 |
Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 2010 |
Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrach | 2010 |
TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon | 2010 |
[Expression of keratin 8 in carbon tetrachloride-induced liver injury of mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Keratin-8; Male; Mice | 2010 |
Sida rhombifolia ssp. retusa seed extract inhibits DEN induced murine hepatic preneoplasia and carbon tetrachloride hepatotoxicity.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferase, Mitochondrial; Carbon Tetrachloride; Chem | 2009 |
Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats.
Topics: Acetaminophen; Alkaloids; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 2009 |
FXR regulates liver repair after CCl4-induced toxic injury.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2010 |
Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Line; Cell | 2010 |
Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2010 |
Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.
Topics: Andrographis; Animals; Anti-Inflammatory Agents; Biological Availability; Carbon Tetrachloride; Carb | 2010 |
Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antioxidants; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2010 |
Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Cycle; Cell Cycle Proteins; Cell Proliferatio | 2010 |
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Chemical and Dru | 2010 |
Shifts in the lymph flow and the lymph composition in toxic hepatitis and their correction by protective substances.
Topics: alpha-Tocopherol; Animals; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2009 |
3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats.
Topics: Alkynes; Animals; Ascorbic Acid; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Inj | 2010 |
Bone marrow mononuclear cell transplantation improves survival and induces hepatocyte proliferation in rats after CCl(4) acute liver damage.
Topics: Alanine Transaminase; Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Proliferation | 2010 |
Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2010 |
Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice.
Topics: Actins; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Catechin; Chemical and Drug Induced | 2010 |
Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via a tumor necrosis factor-alpha-dependent mechanism.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Inter | 2010 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice.
Topics: Animals; Aprotinin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Rela | 2010 |
In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline.
Topics: Animals; Carbolines; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 2010 |
Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Topics: Animals; Bile Ducts; Biomarkers; Calcium-Binding Proteins; Carbon Tetrachloride; Cell Lineage; Cell | 2010 |
Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats.
Topics: Adenosine Triphosphatases; Animals; Blood Chemical Analysis; Butea; Carbon Tetrachloride; Carbon Tet | 2011 |
Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl(4) in male rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; G | 2011 |
Enhancement of P-glycoprotein expression by hepatocyte transplantation in carbon tetrachloride-induced rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfam | 2010 |
Inhibitory effect of MIL glycoprotein on expression of pro-inflammatory mediators in carbon tetrachloride-induced mice liver damage.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 2010 |
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Down-Re | 2010 |
Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2011 |
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cannabinoids; Carbon Tetrachl | 2010 |
Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatectomy; Hepatocytes; Liv | 2010 |
Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.
Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Carbon Tet | 2010 |
Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2010 |
In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Artemisia absinthium; Asparta | 2010 |
Hepatoprotective activities of two Ethiopian medicinal plants.
Topics: Acanthaceae; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2010 |
Protective activity of Jiang-Zhi-Li-Gan against carbon tetrachloride-induced hepatic injury in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2010 |
Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotra | 2010 |
Lack of guanylate cyclase C results in increased mortality in mice following liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury | 2010 |
Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coumarins; Diet | 2010 |
Hepatoprotective, immunomodulatory, and anti-inflammatory activities of selenocystine in experimental liver injury of rats.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyc | 2011 |
Protective effect of partially purified 35 kDa protein from silk worm (Bombyx mori) fecal matter against carbon tetrachloride induced hepatotoxicity and in vitro anti-viral properties.
Topics: Animals; Antioxidants; Antiviral Agents; Bombyx; Camelus; Capripoxvirus; Carbon Tetrachloride; Chemi | 2010 |
Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium-Binding Proteins; Carbon Tetrachloride; Carbon Tetrach | 2011 |
A novel hepatoprotective saponin from Celosia cristata L.
Topics: Animals; Carbon Tetrachloride; Celosia; Chemical and Drug Induced Liver Injury; Dimethylformamide; D | 2010 |
Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol; Cy | 2010 |
Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage.
Topics: Animals; Annona; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Re | 2010 |
Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2010 |
Anti-fibrotic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta in a rat model of CCl(4)-injured liver: potential application to the treatment of hepatic diseases.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cell Differentiation; Cell Line; Cells, Cultured; | 2010 |
Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Caffeine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Femal | 2012 |
Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2010 |
Protective effects of Pergularia daemia roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemi | 2010 |
[Studies on the chemical constituents of Kalimeris indica].
Topics: Anthraquinones; Anti-Inflammatory Agents; Asteraceae; Benzaldehydes; Carbon Tetrachloride; Cell Surv | 2010 |
Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl(4))-induced hepatocyte damage in common carp (Cyprinus carpio).
Topics: Animals; Antioxidants; Aspartate Aminotransferase, Cytoplasmic; Carbon Tetrachloride; Carps; Cells, | 2011 |
Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced | 2011 |
[Hemorheological effects of thiophane on tetrachloromethane induced hepatic damage].
Topics: Animals; Blood Viscosity; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 2010 |
The protective effect of ENA Actimineral resource A on CCl4-induced liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cytoc | 2011 |
Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Topics: Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 2010 |
Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Chemical and | 2010 |
Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical and Drug In | 2011 |
Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Diosge | 2011 |
The effectiveness of ethanolic extract of Amaranthus tricolor L.: A natural hepatoprotective agent.
Topics: Amaranthus; Animals; Antioxidants; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
Protective effects of water extract of clam on normal and CCl₄-induced damage in primary cultured rat hepatocytes.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Corbicula; Glut | 2010 |
Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Berberine; Carbon Tetrachloride; Chemical and D | 2011 |
Antihepatotoxic and antioxidant activities of methanol extract and isolated compounds from Ficus chlamydocarpa.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Carb | 2010 |
Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzoquinones; Carbon Tetrachloride; Chemical and Dr | 2010 |
Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; | 2011 |
Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity.
Topics: Amino Acids; Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Chemical and Drug Induce | 2011 |
A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2011 |
Hepatoprotective and TNF-α inhibitory activity of Zosima absinthifolia extracts and coumarins.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apiaceae; Aspartate Aminotransferases; Carb | 2011 |
Immunomodulative effects of mesenchymal stem cells derived from human embryonic stem cells in vivo and in vitro.
Topics: Animals; Antigens, Surface; Base Sequence; Carbon Tetrachloride; Cell Differentiation; Cell Line; Ch | 2011 |
Hepatoprotection of Graptopetalum paraguayense E. Walther on CCl₄-induced liver damage and inflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2011 |
Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir.
Topics: Alkaloids; Animals; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced | 2011 |
Effects of Phyllanthus acidus (L.) Skeels fruit on carbon tetrachloride-induced acute oxidative damage in livers of rats and mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2011 |
Protective effects of CAPE on liver injury induced by CCL₄: an electron microscopy study.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Male; Microsco | 2011 |
SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Chenodeoxycholic A | 2011 |
Ferulic acid protects against carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carbon Tetrachloride; Chemical | 2011 |
Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Fu | 2012 |
Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced L | 2011 |
Hepatoprotective activity of Luffa acutangula against CCl4 and rifampicin induced liver toxicity in rats: a biochemical and histopathological evaluation.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2010 |
Placenta extract promote liver regeneration in CCl4-injured liver rat model.
Topics: Actins; Albumins; Alkyl and Aryl Transferases; Animals; ATP-Binding Cassette Transporters; Carbon Te | 2011 |
Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Con | 2011 |
Evaluation of the antioxidant and hepatoprotective effect of Majoon-e-Dabeed-ul-ward against carbon tetrachloride induced liver injury.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2012 |
Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation.
Topics: Alanine Transaminase; Animals; Antioxidants; Apiaceae; Aspartate Aminotransferases; Carbon Tetrachlo | 2011 |
Anti-inflammatory properties of Ajuga bracteosa in vivo and in vitro study and their effects on mouse model of liver fibrosis.
Topics: Ajuga; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
Hepatoprotective activity of punarnavashtak kwath, an Ayurvedic formulation, against CCl4-induced hepatotoxicity in rats and on the HepG2 cell line.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2011 |
Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bloo | 2011 |
Early growth response (EGR)-1 is required for timely cell-cycle entry and progression in hepatocytes after acute carbon tetrachloride exposure in mice.
Topics: Animals; Carbon Tetrachloride; Cell Cycle; Cell Proliferation; Chemical and Drug Induced Liver Injur | 2011 |
Protective effects of hyperoside against carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Artemisia; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 2011 |
Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrach | 2011 |
Protective effects of lycorine against carbon tetrachloride induced hepatotoxicity in Swiss albino mice.
Topics: Amaryllidaceae Alkaloids; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2012 |
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2011 |
Protective effect of chrysin on carbon tetrachloride (CCl4)-induced tissue injury in male Wistar rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2011 |
Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase | 2011 |
Inflammation does not always kill hepatocytes during liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2011 |
Hepatoprotective effects of lychee (Litchi chinensis Sonn.): a combination of antioxidant and anti-apoptotic activities.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Carbon Tetrachloride; Chemica | 2011 |
In vitro and in vivo antioxidant effects of the ethanolic extract of Swertia chirayita.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Kidney; Liver; | 2011 |
Studies on the antioxidant and hepatoprotective activities of polysaccharides from Talinum triangulare.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response R | 2011 |
Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Ginkgo | 2011 |
Hepatoprotective effect of Crossostephium chinensis (L.) Makino in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Asteraceae; Carbon Tetrach | 2011 |
Non-invasive oxidative stress markers for liver fibrosis development in the evolution of toxic hepatitis.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2011 |
Hepatoprotective effect of ghrelin on carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cyto | 2011 |
The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Couma | 2011 |
Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug | 2011 |
Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit.
Topics: Animals; Antioxidants; Ascorbic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2011 |
S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2012 |
Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat.
Topics: Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hy | 2011 |
A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2011 |
Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hippophae; Live | 2011 |
Safety of liver surface instillation of plasmid DNA in normal and carbon tetrachloride-induced hepatitis mice.
Topics: Animals; Carbon Tetrachloride; Catheters; Chemical and Drug Induced Liver Injury; Dose-Response Rela | 2011 |
Chlorella vulgaris extract ameliorates carbon tetrachloride-induced acute hepatic injury in mice.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2013 |
Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Artemisia; As | 2011 |
Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta.
Topics: Animals; Antioxidants; Ascomycota; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cul | 2013 |
[Protective effects of shaoganduogan on hepatocyte mitochondria in subacute liver injury rat induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Hepato | 2011 |
Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2011 |
Antioxidant and antihepatotoxic effect of Spirulina laxissima against carbon tetrachloride induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biological Products; Biomarkers; Carbon Tetrachloride; Chemical and Drug Indu | 2011 |
Andrographis paniculata ameliorates carbon tetrachloride (CCl(4))-dependent hepatic damage and toxicity: diminution of oxidative stress.
Topics: Andrographis; Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Carbon Tetrachloride | 2011 |
Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavones; Gene Exp | 2011 |
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.
Topics: Acute Disease; Animals; Aptamers, Nucleotide; Bone Marrow Cells; Carbon Tetrachloride; Cells, Cultur | 2012 |
An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents.
Topics: Animals; Anthraquinones; Artemisia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ch | 2011 |
Effect of fermented Angelicae gigantis Radix on carbon tetrachloride-induced hepatotoxicity and oxidative stress in rats.
Topics: Adipose Tissue, White; Angelica; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induc | 2012 |
Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Body Weight; Capsaicin; Carbon Tetrachloride | 2012 |
Antioxidant, hepatoprotective, and ameliorative effects of methanolic extract of leaves of Grewia mollis Juss. on carbon tetrachloride-treated albino rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachl | 2012 |
Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2011 |
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2011 |
Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Disea | 2011 |
Hepatoprotective effects and mechanisms of dehydrocavidine in rats with carbon tetrachloride-induced hepatic fibrosis.
Topics: Animals; Antioxidants; Apoptosis; Berberine Alkaloids; Carbon Tetrachloride; Chemical and Drug Induc | 2011 |
(Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury.
Topics: Alanine Transaminase; Aldehyde Reductase; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical a | 2012 |
Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2011 |
Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 2011 |
A novel fluorinated stilbene exerts hepatoprotective properties in CCl(4)-induced acute liver damage.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cho | 2011 |
Hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in carbon tetrachloride induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Biological Products; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2011 |
Liver fibrosis protects mice from acute hepatocellular injury.
Topics: Acute Disease; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Int | 2012 |
Antioxidant activities of the leaves of Chrysophyllum albidum G.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2011 |
Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Caspase | 2011 |
[The study of susceptibility to carbon tetrachloride and benzene in offspring of expanded simple tandem repeats mutation mice exposed to formaldehyde].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzene; Carbon Tetrachloride; Chemical | 2011 |
Neutralization of chemokine CXCL14 (BRAK) expression reduces CCl4 induced liver injury and steatosis in mice.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2011 |
Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl₄ induced hepatic oxidative damage and renal failure in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrach | 2011 |
Hepatoprotective action of Radix Paeoniae Rubra aqueous extract against CCl4-induced hepatic damage.
Topics: Animals; Antioxidants; Biphenyl Compounds; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 2011 |
Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced rat hepatic injury.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachlor | 2011 |
Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography; C | 2011 |
Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Adhesion; Cell Proliferation; Cell Transdifferentiati | 2011 |
Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2011 |
Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice.
Topics: Alanine Transaminase; Andrographis; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetra | 2011 |
Protective effect of red-stemmed type of Ipomoea aquatica Forsk against CCl4-induced oxidative damage in mice.
Topics: alpha-Tocopherol; Animals; Anthocyanins; Antioxidants; beta Carotene; Carbon Tetrachloride; Chemical | 2011 |
Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2011 |
CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.
Topics: Animals; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; C | 2012 |
Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Calori | 2012 |
Hepatoprotective effects of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone on CCl4-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrach | 2011 |
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bio | 2012 |
Hepatoprotective effect of Solanum xanthocarpum fruit extract against CCl4 induced acute liver toxicity in experimental animals.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2011 |
Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 2012 |
Attenuation of CCl(4)-induced hepatic oxidative stress in rat by Launaea procumbens.
Topics: Animals; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; DNA F | 2013 |
Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.
Topics: Actins; Animals; Antioxidants; Carbon Tetrachloride; Case-Control Studies; Cell Movement; Cell Proli | 2012 |
Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Cell Separation | 2012 |
Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemica | 2012 |
Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biotransformation; Body We | 2011 |
Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing.
Topics: Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug-Rel | 2012 |
Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Hepatoc | 2012 |
Effects of manual acupuncture at GB34 on carbon tetrachloride-induced acute liver injury in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 2011 |
Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats.
Topics: Animals; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Fun | 2012 |
Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbon Tetrachloride; C | 2012 |
Hepatoprotective effect of Filipendula hexapetala Gilib. (Rosaceae) in carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 2012 |
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2012 |
[Expression of NMDA receptor subunits in rat prefrontal cortex with CCL4-induced hepatic damage after a treatment with Rosmarinus officinalis L].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Plant E | 2012 |
[Hepatoprotective effect of thiophane in rats with experimental carbon tetrachloride-induced hepatitis].
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Carbohydrate Me | 2011 |
Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyperus | 2012 |
Augmenter of liver regeneration may be a candidate for prognosis of HBV related acute-on-chronic liver failure as a regenerative marker.
Topics: Analysis of Variance; Animals; Biomarkers; Carbon Tetrachloride; Case-Control Studies; Chemical and | 2012 |
Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemoki | 2012 |
Ex vivo-expanded bone marrow stem cells home to the liver and ameliorate functional recovery in a mouse model of acute hepatic injury.
Topics: Acute Disease; Alanine Transaminase; Albumins; Animals; Aspartate Aminotransferases; Biomarkers; Bon | 2012 |
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Indu | 2012 |
The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Body Weight; Carbon Tetrachlo | 2011 |
The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical a | 2012 |
[Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Euphorbiaceae; Liver; Plant E | 2010 |
Protective effects of lotus (Nelumbo nucifera Gaertn) germ oil against carbon tetrachloride-induced injury in mice and cultured PC-12 cells.
Topics: Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; DNA Damage; Glutath | 2012 |
Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; | 2012 |
In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia.
Topics: Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carbon Tetrachloride; Catalase; Chelating | 2012 |
Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride; | 2012 |
Adenovirus-mediated dual gene expression of human interleukin-10 and hepatic growth factor exerts protective effect against CCl4-induced hepatocyte injury in rats.
Topics: Adenoviridae; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury | 2012 |
In vitro and in vivo hepatoprotective activity of Cissampelos pareira against carbon-tetrachloride induced hepatic damage.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Cissampelos; H | 2011 |
Hepatoprotective activity of methanolic extract of Hiptage bengalensis leaves against CCl₄-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2012 |
Expression patterns of heat shock protein 25 in carbon tetrachloride-induced rat liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Data Interpretatio | 2013 |
Therapeutic potential of mesenchymal stem cells overexpressing human forkhead box A2 gene in the regeneration of damaged liver tissues.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Differentiation; Cell Lineage; Cells, Cultured; Chem | 2012 |
Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon tetrachloride-induced liver damage in experimental model.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Pois | 2013 |
Phytochemical analysis, hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Euphorbiaceae; | 2012 |
Protective effect of Ssanghwa-tang fermented by Lactobacillus fermentum against carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bioreactors; Carbon Tetrachloride; Chemi | 2011 |
Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Differentiation; Cell Survival; Cell- and Tissue-B | 2012 |
Effect of trazodone and nefazodone on hepatic injury induced by carbon tetrachloride.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2010 |
[A preliminary study of anti-aging and wound healing of recombination cytoglobin].
Topics: Adenoviridae; Aging; Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Catalase; Ce | 2012 |
Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diclofenac; Dis | 2011 |
Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Diosgen | 2012 |
Impairment of α(2)-macroglobulin synthesis in experimental hepatopathic rats treated with turpentine oil.
Topics: Acetaminophen; Acute Disease; alpha-Macroglobulins; Analgesics, Non-Narcotic; Animals; Carbon Tetrac | 2012 |
Meloxicam modulates oxidative stress status, inhibits prostaglandin E2, and abrogates apoptosis in carbon tetrachloride-induced rat hepatic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carbon Tetrachloride; Caspase 3; Chemic | 2012 |
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity.
Topics: Acetaminophen; Actins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galact | 2012 |
Hepatoprotective activity of Feronia limonia root.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrach | 2012 |
A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1.
Topics: Aldehydes; Animals; Binding Sites; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2012 |
Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CCL5; Disease Model | 2012 |
Lygodium flexuosum extract down regulates the expression of proinflammatory cytokines in CCl4-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Medium optimization and potential hepatoprotective effect of mycelial polysaccharides from Pholiota dinghuensis Bi against carbon tetrachloride-induced acute liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Curative and protective effects of L-arginine on carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Arginine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catalase; Chemical and Drug | 2012 |
Pharmacological evaluation of Ipomoea asarifolia (Desr.) against carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 2012 |
Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats.
Topics: Actins; Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2012 |
Protection of the extracts of Lentinus edodes mycelia against carbon-tetrachloride-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Northern; Carbon Tetrachloride | 2012 |
Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice.
Topics: Alanine Transaminase; Amitrole; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Catalase | 2012 |
Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cassia; Chemical a | 2012 |
Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cata | 2012 |
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
Topics: Animals; Apoptosis; Carbon Tetrachloride; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase | 2012 |
Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2012 |
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
Topics: Analysis of Variance; Animals; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced | 2012 |
Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.
Topics: Acetyltransferases; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocyt | 2012 |
Hydroxysafflor yellow A attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting ERK5 signaling.
Topics: Actins; Animals; Carbon Tetrachloride; Carthamus; Chalcone; Chemical and Drug Induced Liver Injury; | 2012 |
Protective role of antithrombin in mouse models of liver injury.
Topics: Animals; Antithrombins; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2012 |
Protective effects of Moutan Cortex Radicis against acute hepatotoxicity.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Bilirubin; Carbon Tetrachloride; Chemical a | 2011 |
Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced | 2013 |
Hepatoprotective activity of Sonchus asper against carbon tetrachloride-induced injuries in male rats: a randomized controlled trial.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl₄-treated mice.
Topics: Actins; Administration, Oral; Albumins; alpha-Fetoproteins; Animals; Antigens, Differentiation; Biom | 2012 |
Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid.
Topics: Animals; Antioxidants; Betulinic Acid; Bignoniaceae; Biomarkers; Carbon Tetrachloride; Chemical and | 2012 |
Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl4-induced liver injury in rats.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carbon Tetrachlorid | 2012 |
Protective effects of a purified saponin mixture from Astragalus corniculatus Bieb., in vivo hepatotoxicity models.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Astragalus | 2013 |
[Protective effect of silymarin on liver injury in mice induced by carbon tetrachloride].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora.
Topics: Animals; Antioxidants; Bilirubin; Biomarkers; Blood Urea Nitrogen; Carbon Tetrachloride; Chemical an | 2012 |
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.
Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2012 |
Changes in the activity of matrix metalloproteinases in regenerating rat liver after CCl4-induced injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Extracellular Matrix; Hepatoc | 2003 |
Hepatoprotective and antioxidant effect of tender coconut water on carbon tetrachloride induced liver injury in rats.
Topics: Animals; Antioxidants; Beverages; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coco | 2003 |
Investigation of the hepatoprotective effects of Sesame (Sesamum indicum L.) in carbon tetrachloride-induced liver toxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Chemical and Drug Induced Liver Injury; Choline | 2012 |
Upregulation of Sirt1 in carbon-tetrachloride-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride; | 2013 |
Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cata | 2012 |
Hepatoprotective activity of Allium paradoxum.
Topics: Alkaline Phosphatase; Allium; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical a | 2012 |
Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Blood Urea Nitrog | 2012 |
A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Cytokin | 2013 |
Hepatoprotective effects of the polysaccharide isolated from Tarphochlamys affinis (Acanthaceae) against CCl4-induced hepatic injury.
Topics: Acanthaceae; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotrans | 2012 |
Protective effect of transplantation of neonatal liver cell nuclei on the model of acute toxic hepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2012 |
Antioxidant and hepatoprotective activity of an ethanol extract of Syzygium jambos (L.) leaves.
Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induc | 2012 |
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Hepa | 2012 |
Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2012 |
Mesenchymal stem cells restore CCl4-induced liver injury by an antioxidative process.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induc | 2012 |
CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2012 |
Measuring covalent binding in hepatotoxicity.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Li | 2007 |
Dynamic contrast-enhanced optical imaging of in vivo organ function.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Contrast Media; Image Interpr | 2012 |
Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucoside.
Topics: Animals; Biphenyl Compounds; Butylene Glycols; Carbon Tetrachloride; Catalase; Chemical and Drug Ind | 2013 |
Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amides; Animals; Aspartate Aminotransferases; Carbon Tet | 2012 |
Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Artemisia; Aspartate Aminotransferases; Carbon Tetrachl | 2013 |
Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats.
Topics: Alkaline Phosphatase; Animals; Bilirubin; Carbon Tetrachloride; Catalase; Chemical and Drug Induced | 2013 |
Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liv | 2012 |
Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L.
Topics: Animals; Antioxidants; Apiaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavo | 2012 |
Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2013 |
[Determination of cefuroxime in liver-injured rat plasma by ultra fast liquid chromatography-tandem mass spectrometry via acidified protein precipitation].
Topics: Animals; Carbon Tetrachloride; Cefuroxime; Chemical and Drug Induced Liver Injury; Chemical Precipit | 2012 |
Radix Paeoniae Rubra and Radix Paeoniae Alba Attenuate CCl4-induced acute liver injury: an ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) based metabolomic approach for the pharmacodynamic study of Traditional Chinese Medicines (TCMs)
Topics: Animals; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2012 |
Hepatoprotective efficacy of Sharbat-e-Deenar against carbon tetrachloride-induced liver damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2012 |
Hepatoprotective effect of herbal drug on CCl(4) induced liver damage.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Carbon Tetrachloride; Ch | 2013 |
Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Primers; F | 2013 |
Effects of nanogold on the alleviation of carbon tetrachloride-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Cell | 2012 |
Nanoemulsified ethanolic extract of Pyllanthus amarus Schum & Thonn ameliorates CCl4 induced hepatotoxicity in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 2012 |
Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts.
Topics: Animals; Antioxidants; Asparagus Plant; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug | 2012 |
[Protective effects of PEG modified recombinant cytoglobin on acute liver injury in mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoglobin; Free Radical Scav | 2012 |
GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride; | 2013 |
Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; Ileum; Immunohis | 2012 |
Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury.
Topics: Animals; Biliary Tract; Carbon Tetrachloride; Cell Lineage; Cell Transdifferentiation; Cells, Cultur | 2013 |
The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Line; Cell Su | 2013 |
Engraftment potential of spheroid-forming hepatic endoderm derived from human embryonic stem cells.
Topics: Albumins; Animals; Biomarkers; Bone Morphogenetic Protein 4; Carbon Tetrachloride; Cell Culture Tech | 2013 |
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Ch | 2013 |
Reversal of carbon tetrachloride-induced hepatic injury by aqueous extract of Artemisia absinthium in Sprague-Dawley rats.
Topics: Animals; Antioxidants; Artemisia absinthium; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2012 |
Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Extracts; Chemical and Drug Induced Liver Injury; | 2002 |
Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Carrier Proteins; CCAAT-Enhancer-Binding Proteins; Che | 2002 |
Anti-inflammatory and hepatoprotective activity of peh-hue-juwa-chi-cao in male rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2002 |
Ameliorative effect of Silene aprica on liver injuries induced by carbon tetrachloride and acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetr | 2002 |
Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransfer | 2002 |
Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.
Topics: Abietanes; Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2002 |
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E.
Topics: Adenoviridae; Animals; Calcium-Binding Proteins; Carbon Tetrachloride; Carrier Proteins; Cell Cycle | 2002 |
Protective effect of a lignan-containing flaxseed extract against CCl(4)-induced hepatic injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; Drug Administrati | 2002 |
Anti-oxidative, anti-inflammatory and hepato-protective effects of Ligustrum robustum.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Capillary Permea | 2002 |
Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Jordan; Liver; | 2002 |
Enzyme release from injured, preserved, and ex vivo reperfused liver does not indicate malfunction.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 2002 |
Early gene expression of hepatocyte growth factor in mononuclear phagocytes of rat liver after administration of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Count; Cells, Cultured; Chemical and Drug Induced Liver Injury; | 2002 |
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Dr | 2002 |
Potential role of regucalcin as a specific biochemical marker of chronic liver injury with carbon tetrachloride administration in rats.
Topics: Animals; Biomarkers; Calcium-Binding Proteins; Carbon Tetrachloride; Carboxylic Ester Hydrolases; Ch | 2002 |
Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine | 2003 |
Pien Tze Huang protects the liver against carbon tetrachloride-induced damage.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Mice; | 2002 |
The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2002 |
Hepatoprotective and antihyperliposis activities of in vitro cultured Anoectochilus formosanus.
Topics: Adipose Tissue; Animals; Antioxidants; Aurothioglucose; Carbon Tetrachloride; Chemical and Drug Indu | 2003 |
[The further studies on the pharmacological actions of Bupleurum smithii var. parvifolium].
Topics: Analgesics; Animals; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, | 1998 |
Biomedicine. Love, honor, and protect (your liver).
Topics: Animals; Carbon Tetrachloride; Cell Communication; Cell Division; Chemical and Drug Induced Liver In | 2003 |
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2003 |
[Study on hepatic-protective effect of "yinzhihuang" granula].
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Car | 2001 |
Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.
Topics: Animals; Carbon Tetrachloride; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Cinnam | 2003 |
Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Cordyceps; D | 2003 |
Effect of D-003, a mixture of high molecular weight primary acids from sugar cane wax, on CL4C-induced liver acute injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids; He | 2002 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2003 |
Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Chemical and Drug In | 2003 |
Hepatoprotective effect of Foeniculum vulgare essential oil.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2003 |
Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.
Topics: Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Cyclin D1; Fat | 2003 |
Combined histomorphometric and gene-expression profiling applied to toxicology.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Data Interpretation, Statisti | 2003 |
Hepatoprotective activity of leaves of Kalanchoe pinnata Pers.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; India; K | 2003 |
Efficacy of different Cynara scolymus preparations on liver complaints.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Carbon Tetrachloride; Chemical and | 2003 |
Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Basidiomycota; Biphenyl Co | 2003 |
Glycosmis arborea extract as a hepatoprotective agent.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Body Weight; Carbon Tetrachlorid | 2003 |
Renal effects of selective cyclooxygenase inhibition in experimental liver disease.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygen | 2003 |
Clinical usefulness of edaravone for acute liver injury.
Topics: Animals; Antipyrine; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Edarav | 2003 |
Hepatoprotective effect of the extract and isocytisoside from Aquilegia vulgaris.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; Liv | 2003 |
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Che | 2003 |
Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Topics: Animals; Antirheumatic Agents; ATP-Binding Cassette Transporters; Carbon Tetrachloride; Carrier Prot | 2003 |
Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2003 |
Alleviating effects of si-ni-san, a traditional Chinese prescription, on experimental liver injury and its mechanisms.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Respons | 2003 |
The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Ch | 2003 |
Effect of propriety herbal formulation against chronic carbon tetrachloride induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachlori | 2002 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Immunohistochemistry; Male; N | 2003 |
[Prednisone in the evolution of experimental toxic hepatitis from carbon tetrachloride: histological findings].
Topics: Biological Evolution; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Prednison | 1959 |
Liver and plasma phosphatides during the initial stages of carbon tetrachloride intoxication in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1963 |
Cell proliferation and fiber formation in chronic carbon tetrachloride intoxication. A morphologic and chemical study.
Topics: Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Hepatitis; Liver Cirrho | 1963 |
[Serum enzymes as indicators of experimental carbon tetrachloride damage and its therapeutic modification].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fructo | 1962 |
[Hepato-protective action of oxypurines in experimental poisoning of rats with carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis; Orotic Acid; Purin | 1963 |
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE IN MICE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorp | 1963 |
SOME OBSERVATIONS ON THE POSSIBLE MEDIATION OF CARBON TETRACHLORIDE HEPATOTOXICITY THROUGH THE CENTRAL NERVOUS SYSTEM.
Topics: Adrenal Medulla; Brain; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catecholamines; Cats; | 1963 |
SERUM LIPOPROTEIN LEVELS IN RATS WITH LIVER DAMAGE INDUCED BY CARBON TETRACHLORIDE.
Topics: Blood Proteins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Live | 1963 |
LIVER PARENCHYMAL CELL INJURY. I. INITIAL ALTERATIONS OF THE CELL FOLLOWING POISONING WITH CARBON TETRACHLORIDE.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Chemical and | 1963 |
HEPATIC PARENCHYMAL CELL ALTERATIONS AFTER LONG-TERM CARBON TETRACHLORIDE ADMINISTRATION. A LIGHT AND ELECTRON MICROSCOPIC STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electr | 1963 |
BILIARY DUCTULES AND BILE SECRETION.
Topics: Amides; Bile; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholagogues | 1963 |
[ACTION OF ALPHA-TOCOPHEROL IN EXPERIMENTAL HEPATIC NECROSIS BY CARBON TETRACHLORIDE].
Topics: Alanine Transaminase; alpha-Tocopherol; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Te | 1963 |
RAT LIVER ADENOSINETRIPHOSPHATASE. CHANGES FOLLOWING EXPERIMENTAL CARBON TETRACHLORIDE ADMINISTRATION.
Topics: Adenosine Triphosphatases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1963 |
[EFFECT OF ASCORBIC ACID ON EXPERIMENTAL LIVER DAMAGE. I. SERUM TRANSAMINASE IN CARBON TETRACHLORIDE LESIONS].
Topics: Alanine Transaminase; Ascorbic Acid; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbo | 1963 |
[EXAMINATION OF SOME ENZYME ACTIVITIES IN THE MOUSE LIVER AND KIDNEY BEFORE AND AFTER CARBON TETRACHLORIDE OR URANYL NITRATE ADMINISTRATION].
Topics: Acid Phosphatase; Alkaline Phosphatase; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemic | 1963 |
[RESEARCH ON THE PROBLEM OF MODIFICATION OF EXPERIMENTAL LIVER DAMAGE BY CARBON TETRACHLORIDE IN CHICKENS].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1963 |
[THE EFFECT OF MAGNESIUM AND VITAMIN E ON THE ACUTE CARBON TETRACHLORIDE DAMAGE OF THE RAT LIVER].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1963 |
[THE EFFECT OF SERUM FROM PARTIALLY HEPATECTOMIZED RATS ON CHRONIC LIVER DAMAGE CAUSED BY CARBON TETRACHLORIDE].
Topics: Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1963 |
[EXAMINATION OF THE EFFECT OF SEROTONIN IN THE EARLY PHASE OF LIVER DAMAGE CAUSED BY CARBON TETRACHLORIDE].
Topics: Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug | 1963 |
[EFFECT OF NUCLEOTIDES ON HEPATIC GLUTAMIC-PYRUVIC TRANSAMINASE IN RATS INTOXICATED WITH CARBON TETRACHLORIDE].
Topics: Alanine Transaminase; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induce | 1963 |
[ON THE MECHANISM OF ACTION OF CARBON TETRACHLORIDE IN INDUCING CHANGES IN SOME SERUM ENZYMES OF PROBABLE HEPATIC ORIGIN].
Topics: Adrenal Glands; Adrenalectomy; Alanine Transaminase; Aspartate Aminotransferases; Body Temperature; | 1963 |
THE EFFECT OF CASTRATION AND TESTOSTERONE TREATMENT ON LIVER HEALING IN MALE RATS AFTER CARBON TETRACHLORIDE INJURY.
Topics: Alanine Transaminase; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Castration; Chemical and | 1964 |
THE EFFECT OF SPINAL CORD TRANSECTION ON CARBON TETRACHLORIDE HEPATOTOXICITY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1964 |
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE - A LONG TERM STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1963 |
THE USE OF THE OSMIUM-ETHYL GALLATE TECHNIQUE IN THE STUDY OF CARBON TETRACHLORIDE LIVER INJURY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gallic | 1964 |
[COLLAGENASE ACTIVITY OF CERTAIN HEPATIC EXTRACTS. ITS CHANGES IN THE CARBON TETRACHLORIDE-POISONED RAT].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1964 |
[EVALUATION OF HEPATIC LESIONS OF VARIOUS ORIGINS BY MEANS OF FUNCTION TESTS. I. TREATMENT WITH CARBON TETRACHLORIDE].
Topics: Biopsy; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury | 1963 |
RELATIVE HEPATOTOXICITY: PENTANE, TRICHLOROETHYLENE, BENZENE, CARBON TETRACHLORIDE.
Topics: Aspartate Aminotransferases; Benzene; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1964 |
ENDOTOXIN SUSCEPTIBILITY FOLLOWING HEPATIC INJURY BY CARBON TETRACHLORIDE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chick | 1964 |
[EFFECT OF PARTIAL HEPATECTOMY ON THE RESTITUTION OF THE ANGIOARCHITECTONICS IN THE LIVER OF RATS WITH CARBON TETRACHLORIDE CIRRHOSIS].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepate | 1964 |
ENZYME ACTIVITIES DURING HEPATIC INJURY CAUSED BY CARBON TETRACHLORIDE.
Topics: Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; He | 1964 |
[ON THE PROBLEM OF THE PREDNISONE EFFECT IN ACUTE LIVER DAMAGE (CARBON TETRACHLORIDE IN RAT LIVER)].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepati | 1964 |
EFFECT OF IRON LOADING UPON THE FORMATION OF COLLAGEN IN THE HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE.
Topics: Alanine Transaminase; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; | 1964 |
[STUDY OF ENZYME ACTIVITY IN THE BLOOD OF RATS INTOXICATED WITH CARBON TETRACHLORIDE AND PROTECTED WITH METHIONINE METHYLSULFONIUM CHLORIDE].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Clinic | 1964 |
[A STUDY OF THE FREE AMINO ACIDS IN THE SERUM OF LIVER DISEASES].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Blood; Carbon Tetrachloride; Chemical and Drug Ind | 1964 |
[ON SOME SEROLOGICAL FEATURES IN RATS POISONED WITH CARBON TETRACHLORIDE].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Comple | 1964 |
[FORMATION OF THE SERUM PROTEIN-BOUND CARBOHYDRATE- AND HAPTOGLOBIN-LEVEL IN EXPERIMENTAL LIVER DAMAGE IN RATS].
Topics: Biphenyl Compounds; Blood Proteins; Carbohydrates; Carbon Tetrachloride; Chemical and Drug Induced L | 1964 |
STUDIES ON CARBON TETRACHLORIDE INTOXICATION. II. DEPRESSED AMINO ACID INCORPORATION INTO MITOCHONDRIAL PROTEIN AND CYTOCHROME C.
Topics: Amino Acids; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1964 |
THE EFFECT OF LIVER IMBALANCE ON THE DEVELOPMENT OF ORAL TUMORS IN MICE FOLLOWING THE APPLICATION OF BENZPYRENE OR TOBACCO TAR.
Topics: Alcohols; Benzopyrenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Hepat | 1964 |
CHANGES IN LIPID METABOLISM DURING THE DEVELOPMENT OF THE FATTY LIVER.
Topics: Adipose Tissue; Amides; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1964 |
[THE EFFECT OF SERUM FROM SUBTOTALLY HEPATECTOMIZED RATS ON CHRONIC LIVER DAMAGE CAUSED BY CARBON TETRACHLORIDE].
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 1964 |
[ACTION OF ADENOSINE MONOPHOSPHORIC ACID ON CARBON TETRACHLORIDE-INDUCED TOXIC HEPATITIS].
Topics: Adenine Nucleotides; Adenosine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and D | 1964 |
CARBON TETRACHLORIDE HEPATOTOXICITY: THE DIRECT ACTION OF CCL4 ON THE LIVER.
Topics: Bile; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1964 |
THE EFFECT OF CARBON TETRACHLORIDE ON HEPATIC LIPID METABOLISM.
Topics: Acetates; Alanine Transaminase; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 1964 |
[RELATIONS BETWEEN THE ANTINECROTIC AND HEPATOPROTECTIVE ACTION OF ESSENTIAL PHOSPHOLIPIDS AND ENZYMATIC ACTIVITY IN THE BLOOD OF RATS POISONED WITH CARBON TETRACHLORIDE].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbon Tetrachloride | 1964 |
THE SYNTHESIS OF SULPHATED MUCOPOLYSACCHARIDE AT SITES OF HEPATIC FIBROSIS INDUCED BY CARBON TETRACHLORIDE, AMYLOIDOSIS AND THE IMPLANTATION OF CATGUT.
Topics: Amyloidosis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catgut; Chemical and Drug Induced | 1964 |
LIVER PARENCHYMAL CELL INJURY. II. CYTOCHEMICAL EVENTS CONCERNED WITH MITOCHONDRIAL DYSFUNCTION FOLLOWING POISONING WITH CARBON TETRACHLORIDE.
Topics: Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1964 |
[ON SOME PARTICULAR MANIFESTATIONS DERIVED FROM THE ASSOCIATED ACTION OF CARBON TETRACHLORIDE AND MINERAL OILS].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dermat | 1964 |
[THALIDOMIDE EMBRYOPATHY IN RABBITS FOLLOWING TRANSIENT LIVER DAMAGE IN THE MOTHER BY CARBON TETRACHLORIDE].
Topics: Abnormalities, Drug-Induced; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1964 |
A CORRELATION OF THE EFFECTS OF CERVICAL CORDOTOMY, HYPOTHERMIA AND CATECHOLAMINES ON CARBON TETRACHLORIDE-INDUCED HEPATIC NECROSIS.
Topics: Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catecholamines; Chemical and | 1965 |
EFFECT OF DIETARY PROTEIN ON CARBON TETRACHLORIDE-INDUCED HEPATIC FIBROGENESIS IN ALBINO RATS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietar | 1965 |
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1965 |
SOME SEROLOGICAL PECULIARITIES IN RATS INTOXICATED BY CARBON TETRACHLORIDE.
Topics: Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1964 |
ALTERATIONS OF AMMONIA METABOLISM IN THE CEREBRAL CORTEX OF RATS WITH HEPATIC DAMAGE INDUCED BY CARBON TETRACHLORIDE.
Topics: Aminobutyrates; Ammonia; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cere | 1965 |
THE INFLUENCE OF OROTIC ACID ON LIVER PARENCHYMA. IV. CHANGES IN SERUM AND LIVER LIPIDS DUE TO CHRONIC CARBON TETRACHLORIDE INTOXICATION.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Choles | 1964 |
PRELIMINARY STUDIES ON EXPERIMENTAL HYPERBILIRUBINEMIA AND HEPATIC COMA IN THE HORSE.
Topics: Ammonia; Animals; Blood Chemical Analysis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1965 |
EFFECTS OF CARBON TETRACHLORIDE ON GUINEA PIG LIVER.
Topics: Amino Acids; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1965 |
CARDIAC HYPERTROPHY IN RATS WITH CARBON TETRACHLORIDE CIRRHOSIS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cardiomegaly; Chemical and Drug Induced Liver | 1965 |
ANTIDOTAL EFFECT OF AMINOACETONITRILE AGAINST THE BIOCHEMICAL INJURY OF THE MICROSOMAL AMINO-ACID INCORPORATING SYSTEM INDUCED IN VIVO BY CARBON TETRACHLORIDE OR DIMETHYLNITROSAMINE.
Topics: Amino Acids; Aminoacetonitrile; Antidotes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1965 |
HEPATIC AND SERUM CHANGES FOLLOWING REPEATED ADMINISTRATION OF SMALL AMOUNTS OF CARBON TETRACHLORIDE TO SHEEP.
Topics: Animals; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1965 |
TOLERANCE TO CARBON TETRACHLORIDE IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug T | 1965 |
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch | 1965 |
FIBROGENESIS ALONG THE HEPATIC SINUSOIDS IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS. AN ELECTRON MICROSCOPIC STUDY.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Collag | 1965 |
EXPERIMENTAL LIVER POISONING OF THE FROG (RANA PIPIENS) WITH CARBON TETRACHLORIDE. I. LIVER-GLYCOGEN STORAGE, BLOOD-GLUCOSE LEVEL, AND CYTOCHROME-OXIDASE ACTIVITY.
Topics: Animals; Anura; Arachis; Blood Glucose; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Pois | 1965 |
RATE OF INCREASE IN PLASMA LEVELS OF CYTOPLASMIC AND MITOCHONDRIAL ENZYMES IN EXPERIMENTAL CARBON TETRACHLORIDE HEPATOTOXICITY.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbon Tetrachloride | 1965 |
ENHANCEMENT OF THE POLYURIDYLIC ACID-DIRECTED PHENYLALANINE POLYMERIZATION IN LIVER-MICROSOME PREPARATIONS FROM RATS TREATED WITH CARBON TETRACHLORIDE OR DIMETHYLNITROSAMINE.
Topics: Amino Acids; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I | 1965 |
PLASMA FREE FATTY ACID TURNOVER IN CARBON TETRACHLORIDE-TREATED RATS.
Topics: Blood Volume; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1965 |
[DIRECT CARBON TETRACHLORIDE EFFECT OF THE MEMBRANE SYSTEM OF THE CELL].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Chemical and Drug Induced Liver | 1965 |
A NOTE ON THE RELATIVE TOXIC ACTIVITIES OF TETRACHLOROMETHANE AND TRICHLORO-FLUORO-METHANE ON THE RAT.
Topics: Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1965 |
Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.
Topics: Actins; Animals; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2003 |
Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.
Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 2003 |
Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Injections, Int | 2003 |
Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2004 |
Apoptosis of hepatic stellate cells in carbon tetrachloride induced acute liver injury of the rat: analysis of isolated hepatic stellate cells.
Topics: Acute Disease; Alanine Transaminase; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachl | 2003 |
4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells.
Topics: Actins; Acute Disease; Aldehydes; Animals; Apoptosis; Carbon Tetrachloride; Cell Death; Cells, Cultu | 2004 |
The regulation of liver regeneration by the plasmin/alpha 2-antiplasmin system.
Topics: alpha-2-Antiplasmin; Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver I | 2004 |
Electrophysiological effects of anthopleurin-Q on rat hepatocytes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Calcium Channels; Carbon Tetrac | 2004 |
Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Basidiomycota; Carbon Tetrachloride; Cell Extracts; Chemical and Drug Induced | 2003 |
Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine.
Topics: Administration, Oral; Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; | 2003 |
Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice.
Topics: Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Hepatectomy; H | 2004 |
Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO(2) on CCl(4)-induced liver damage.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bupl | 2004 |
Comparing an in vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese | 2004 |
Effects of lycopene-beadlet or tomato-powder feeding on carbon tetrachloride-induced hepatotoxicty in rats.
Topics: Administration, Oral; Animal Feed; Animals; Antioxidants; Carbon Tetrachloride; Carotenoids; Chemica | 2004 |
Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Rel | 2004 |
Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ferns; Hexobarbital; Lipid Pe | 2004 |
Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity.
Topics: Aging; Animals; Blotting, Western; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induced Liv | 2004 |
Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatocytes; M | 2004 |
Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Heat-Shock | 2004 |
Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Hepatocytes; Liver | 2004 |
Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Car | 2003 |
Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lawsonia Plant; Liver Functio | 2003 |
Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Drug Evaluati | 2004 |
[Morphology of portal hypertension at the early stage of liver damage induced by CCl4: an experimental study with dogs].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2004 |
Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Fats; Lipid Peroxidat | 2003 |
Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caf | 2004 |
Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Chemical | 2002 |
Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytotoxins; Dr | 2004 |
Free radical oxidation and catalytic activity of aconitate hydratase in rat liver under normal conditions and during toxic hepatitis.
Topics: Aconitate Hydratase; Animals; Antioxidants; Calcium; Carbon Tetrachloride; Chemical and Drug Induced | 2004 |
Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2004 |
In vitro biosynthesis of plasma proteins under ischemic conditions of closed-circuit perfusion of healthy and intoxicated rabbit liver.
Topics: Acute-Phase Proteins; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2004 |
Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Catalase; Chemical | 2004 |
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2004 |
Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cucurbi | 1999 |
Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation.
Topics: Aniline Compounds; Animals; Bile Ducts; Biological Transport, Active; Carbon Tetrachloride; Chemical | 2005 |
Reevaluation of bone marrow-derived cells as a source for hepatocyte regeneration.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Chemical | 2004 |
Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat.
Topics: Acanthaceae; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; L | 2005 |
Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Car | 2005 |
Hepatoprotective properties of Commiphora opobalsamum ("Balessan"), a traditional medicinal plant of Saudi Arabia.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Commiphora; Female; Liver Dis | 2004 |
Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect.
Topics: Administration, Oral; Alanine Transaminase; Animals; Calorimetry, Differential Scanning; Carbon Tetr | 2005 |
Hepatoprotective activity of the constituents in Swertia pseudochinensis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2005 |
Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2005 |
Effect of Sinai san decoction on the development of non-alcoholic steatohepatitis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Chemi | 2005 |
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enz | 2005 |
Expression of osteoactivin in rat and human liver and isolated rat liver cells.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Lineage; Cells, Cultured; Chemical and Drug Induc | 2005 |
Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.
Topics: Acetaminophen; Aflatoxin B1; Albumins; Animals; Benzoquinones; Blotting, Western; Carbon Tetrachlori | 2005 |
Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance-spectroscopy-based metabonomic analysis.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Ind | 2005 |
PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage.
Topics: Acute-Phase Proteins; Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced L | 2005 |
Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Disea | 2005 |
[Protective effect of orgnoselenium from Se-enriched lactobacillus on lipid peroxidation reaction and NK cell activity in spleen of liver injury mice].
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Glut | 2005 |
Mechanisms of apigenin-7-glucoside as a hepatoprotective agent.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Antioxidants; Apigenin; Aspartate Aminot | 2005 |
Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Replication; Male; Phylla | 2005 |
Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus flavonoid as compared to vitamin E in CCl4 induced liver damage in rats.
Topics: Allyl Compounds; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ficus; Flavo | 2005 |
Protective effect of fufanghuangqiduogan against acute liver injury in mice.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2005 |
Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl(4)-induced hepatic damage of HEAI extract.
Topics: Animals; Basidiomycota; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver In | 2005 |
Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats.
Topics: Acute Disease; Alanine Transaminase; Allyl Compounds; Animals; Aspartate Aminotransferases; Biphenyl | 2005 |
Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Hepatocytes; | 2005 |
Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA- | 2005 |
Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cinnamates; Disease Models, A | 2005 |
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2005 |
[L-[1-13C] phenylalanie breath test as a quantitative liver function assessment--a study on rats].
Topics: Animals; Breath Tests; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemic | 2005 |
Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; | 2005 |
Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonate 5-Lipoxygenase; Carbon Tetrachloride; Carr | 2005 |
Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animal Feed; Animals; Aspartate Aminotransferases; Carbo | 2005 |
[The effect and mechanism of Nocardia rubra cell wall skeleton treatment on mice with acute hepatitis induced by CCl4].
Topics: Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Wall Ske | 2005 |
Chemistry and hepatoprotective activity of an active fraction from Barleria prionitis Linn. in experimental animals.
Topics: Acanthaceae; Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug I | 2005 |
Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Flavonols; Free | 2005 |
Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2005 |
Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis, Animal; Lamiaceae; | 2005 |
Effects of dietary supplementation with vitamin E and selenium on rat hepatic stellate cell apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diet | 2005 |
Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 2005 |
L-[1-13C] phenylalanine breath test results reflect the activity of phenylalanine hydroxylase in carbon tetrachloride acute injured rat liver.
Topics: Acute Disease; Animals; Breath Tests; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 2006 |
Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Amaranth Dye; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Li | 2006 |
Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Chemical and Drug Induced Live | 2006 |
Hepatoprotection of oleanolic acid is related to its inhibition on mitochondrial permeability transition.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Carbon Tetrachloride; Chemical | 2005 |
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransf | 2005 |
Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.
Topics: Acetaminophen; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2006 |
Regulation of hepatocyte engraftment and proliferation after cytotoxic drug-induced perturbation of the rat liver.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Carbon Tetrac | 2005 |
Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.
Topics: Animals; bcl-X Protein; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Concanavalin A | 2004 |
The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver.
Topics: Animals; Calendula; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chrysanthemum; Cor | 2005 |
Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fruit; Liver; Male; Opuntia; | 2005 |
Distribution and isoforms of epimorphin in carbon tetrachloride-induced acute liver injury in mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Blotting, Western; Carbon Tetrachloride; Cell Aggregat | 2005 |
The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice.
Topics: Aldehydes; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2006 |
[Comparing studies on the differences of CCl4 liver injury and immunity liver injury mice models].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2005 |
Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats.
Topics: Alkaline Phosphatase; Animals; Beta vulgaris; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Comparative evaluation of hepatoprotective activity of carotenoids of microalgae.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bacterial Proteins | 2005 |
Protective effect of glycoprotein isolated from Ulmus davidiana Nakai on carbon tetrachloride-induced mouse liver injury.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Cell Line; Chemical and Drug Induced Liver In | 2006 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tet | 2005 |
Spermine increases arginase activity in the liver after carbon tetrachloride-induced hepatic injury in Long-Evans rats.
Topics: Animals; Arginase; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Live | 2006 |
Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats.
Topics: Albumins; alpha-Fetoproteins; Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation | 2006 |
Hepatic stellate cells express synemin, a protein bridging intermediate filaments to focal adhesions.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver I | 2006 |
Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.
Topics: 2-Acetylaminofluorene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride | 2006 |
In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; C | 2006 |
Hepatoprotective effect of a hot-water extract from the edible thorny oyster Spondylus varius on carbon tetrachloride-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2006 |
Hepatoprotective effect of extracts from Pergularia daemia Forsk.
Topics: Administration, Oral; Animals; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2006 |
Crotalic and emarginellic acids: two triterpenes from Crotalaria emarginella and anti-inflammatory and anti-hepatotoxic activity of crotalic acid.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cro | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
Hepatoprotective activity of Hemidesmus indicus R. br. in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2006 |
(14)C-lidocaine disposition in serum and tissues of normal and liver diseased rats.
Topics: Anesthetics, Local; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced L | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug | 2006 |
Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Chemical and Drug Induced | 2006 |
Glycoprotein isolated from Ulmus davidiana NAKAI protects against carbon tetrachloride-induced liver injury in the mouse.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Catalase; Cell Survival; Cells, Cultured; Chemi | 2006 |
[Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat].
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2006 |
Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance.
Topics: Administration, Buccal; Alanine Transaminase; Amines; Animals; Antioxidants; Aspartate Aminotransfer | 2006 |
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids, M | 2006 |
Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Carb | 2006 |
Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 2006 |
Enhanced therapeutic potential of naringenin-phospholipid complex in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Chemi | 2006 |
Antioxidative and in vitro hepatoprotective activity of Bupleurum kaoi leaf infusion.
Topics: Acetaminophen; Animals; Antioxidants; Biphenyl Compounds; Bupleurum; Carbon Tetrachloride; Cells, Cu | 2006 |
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Resp | 2006 |
In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice.
Topics: Animals; Animals, Newborn; Antigens, CD34; Bone Marrow; Carbon Tetrachloride; Cell Differentiation; | 2006 |
Dynamic changes of heme oxygenase-1 and carbon monoxide production in acute liver injury induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Monoxide; Carb | 2006 |
Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell | 2006 |
Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCl4-induced liver damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2006 |
Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Diet; Dietary Fats | 2006 |
[Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation].
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hematopoie | 2006 |
Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Carbon Tet | 2007 |
The hepatoprotective activity of kinsenoside from Anoectochilus formosanus.
Topics: 4-Butyrolactone; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lethal Dose | 2007 |
Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice.
Topics: Animals; Antioxidants; Beverages; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyto | 2007 |
Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L.
Topics: Animals; Cajanus; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relati | 2006 |
Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury.
Topics: Actins; Animals; Antigens, CD34; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachlorid | 2006 |
Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice.
Topics: Aldehydes; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Cy | 2007 |
Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Extracellula | 2007 |
Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dis | 2007 |
Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats.
Topics: Animals; Antioxidants; Camellia; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 2007 |
Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Caffeic Acids; Carbon Tetr | 2007 |
Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cath | 2007 |
Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2007 |
Rheumatoid factor induction in murine models of liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autoimmunity; Carbon Tetrachloride; Chem | 2007 |
Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Caffeic Acids; Carbon Tetr | 2007 |
The effect of oculo-acupuncture on acute hepatic injury induced by carbon tetrachloride in dogs.
Topics: Acupuncture Points; Acupuncture Therapy; Alanine Transaminase; Animals; Aspartate Aminotransferases; | 2007 |
Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2007 |
Involvement of transforming growth factor-beta in the expression of gicerin, a cell adhesion molecule, in the regeneration of hepatocytes.
Topics: Animals; Carbon Tetrachloride; CD146 Antigen; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2007 |
[Cystic degeneration in liver injury induced by CCl4 in SD rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cysts; Disease Models, Animal | 2006 |
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Caspase 3; Cells, Cult | 2007 |
Hepatoprotective effect of a protein-enriched fraction from the maggots (Musca domestica) against CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2007 |
Identification and properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 2007 |
Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Filipendula; Li | 2006 |
Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered.
Topics: Animals; Ascitic Fluid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Injections, In | 2007 |
[Committed differentiation of transplanted bone derived mesenchymal stem cells and their potential to amend damaged liver functions: in vivo experiment with mice].
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Transdifferentiation; Cells, Cultured; Che | 2007 |
[Hepatocyte mitochondrion respiratory chain in rats with experimental toxic hepatitis].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochromes c; Dinitrophenols | 2007 |
Yellow tea is more potent than other types of tea in suppressing liver toxicity induced by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Beverages; Camellia sinensis; Carbon Tetrachloride; Chemical and Drug Induced | 2007 |
Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2007 |
The pharmacodynamics of mivacurium in the rabbit with carbon tetrachloride-induced liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholinesterases; | 2007 |
Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Chemi | 2007 |
Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats.
Topics: Acetates; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Free Radica | 2007 |
Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 2007 |
Evaluation of hepatoprotective activity of Clerodendrum serratum L.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clerodendrum; Cytoprotection; | 2007 |
Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2007 |
Protective role of genistein in acute liver damage induced by carbon tetrachloride.
Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2007 |
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical | 2007 |
Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2007 |
Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells.
Topics: Animals; Carbon Tetrachloride; Carrier Proteins; Carrier State; Chemical and Drug Induced Liver Inju | 2007 |
Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apoptosis; Carbon Tetrach | 2007 |
Protective effect of some tropical vegetables against CCl4-induced hepatic damage.
Topics: Alanine Transaminase; Amaranthus; Animals; Aspartate Aminotransferases; Blood Proteins; Carbon Tetra | 2007 |
Preventive effect of D-002, a mixture of long-chain alcohols from beeswax, on the liver damage induced with CCl4 in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Alcohols; | 2007 |
Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cupressus | 2007 |
[The tracking of allogenic grafted rat bone marrow stem cells in rat liver and their role on repairing injured liver].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow Transplantation; Carbon Tetr | 2007 |
Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats.
Topics: Alkaline Phosphatase; Andrographis; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachl | 2008 |
Calotropis procera latex affords protection against carbon tetrachloride induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calotropis; Carbon Tetrachloride; Catala | 2007 |
Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Carbon Tetrachloride; Cell Line; Cell Survival; Che | 2007 |
In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2007 |
Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ether; Free Radica | 2007 |
Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 2007 |
Hepatoprotective activity of Clerodendrum inerme against CCl4 induced hepatic injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Blo | 2007 |
Radical scavenging activity of Trianthema triquetra in male albino rats intoxicated with CCl4.
Topics: Aizoaceae; Animals; Ascorbic Acid; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver I | 2007 |
Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glucans; Liver; | 2008 |
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; | 2008 |
Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2008 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 2007 |
Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransferases; Biotransformation; Ca | 2007 |
Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.
Topics: Animals; Carbon Tetrachloride; Carnosine; Chemical and Drug Induced Liver Injury; Cholecalciferol; C | 2008 |
Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase | 2008 |
Changes in the concentration of tissue inhibitor of type 1 metalloproteinases in blood serum and liver of mice with CCl4-induced hepatitis.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepat | 2007 |
Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells.
Topics: Animals; Carbon Tetrachloride; Cell Death; Ceramides; Chemical and Drug Induced Liver Injury; Ethano | 2008 |
Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Animals; Aspartate Aminotransferas | 2007 |
Superiority of serum type-I arginase and ornithine carbamyltransferase in the detection of toxicant-induced acute hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Arginase; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 2008 |
[Effect of Danxiongfang and its components on experimental liver injury models induced by CCl4 in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2007 |
Liver protective effects of Morinda citrifolia (Noni).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Comparison of the preventive activity of isorhamnetin glycosides from atsumi-kabu (red turnip, Brassica, campestris L.) leaves on carbon tetrachloride-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Brassica; Carbon Tetrachloride; Chemical | 2008 |
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Cryptomeria; Cyclo | 2008 |
Intake of purple grape juice as a hepatoprotective agent in Wistar rats.
Topics: Animals; Anthocyanins; Antioxidants; Beverages; Carbon Tetrachloride; Catalase; Chemical and Drug In | 2008 |
Reduced liver injury in the interleukin-6 knockout mice by chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene Expression Re | 2008 |
Clearance of bacterial lipopolysaccharides and lipid A by the liver and the role of argininosuccinate synthase.
Topics: Animals; Argininosuccinate Synthase; Carbon Tetrachloride; Cell Culture Techniques; Cell Line, Trans | 2008 |
Critical role of CD44 in hepatotoxin-mediated liver injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; H | 2008 |
Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression.
Topics: Activins; Animals; Autocrine Communication; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug | 2008 |
Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachlori | 2008 |
[Study of hepatoprotective activity of ethylmethylhydroxypyridine fumarate and lipoate in the experimental toxic hepatitis].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Femal | 2007 |
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu.
Topics: Acetic Acid; Alcoholic Beverages; Animals; Antioxidants; Carbon Tetrachloride; Carcinoma, Hepatocell | 2008 |
Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Caspase 3; Caspase 8; Catalase; Chemical and Drug Indu | 2008 |
Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; D | 2008 |
Antioxidant and hepatoprotective effects of Cyathea phalerata Mart. (Cyatheaceae).
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; Dos | 2008 |
Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Flavonoids; | 2008 |
EVP-ABD-enhanced MRI to evaluate diffuse liver disease in a rat model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Contrast Media; Disease Model | 2008 |
[Pharmacological studies on liver-acting agents. 1. Comparative study of the toxicity of ethionine and CCl-4 and their effects on the liver].
Topics: Animals; Blood Proteins; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1966 |
Biochemical changes in rat liver after acute beryllium poisoning.
Topics: Acid Phosphatase; Animals; Berylliosis; Blood Glucose; Calcium; Carbon Tetrachloride; Chemical and D | 1967 |
Potentiation of carbon tetrachloride toxicity by dimethyl sulphoxide.
Topics: Animals; Aspartate Aminotransferases; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 1967 |
[Studies of liver and bile duct functions. 3. 131-I-rose bengal test of experimental liver disorders in rabbits].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Iodine Radioisoto | 1967 |
Liver function: postprandial urea nitrogen elevation and indocyanine green clearance in the dog.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biopsy; Blood Urea Nitrogen; Carbon Tetr | 1967 |
Serum transaminase levels in treated fasciola hepatica infected sheep.
Topics: Alanine Transaminase; Animals; Anthelmintics; Aspartate Aminotransferases; Biphenyl Compounds; Carbo | 1967 |
[Experimental study on the significance of rheumatic serum reaction in liver diseases--serological observation of the rabbit administered with carbon tetrachloride].
Topics: Animals; Antibody Formation; Antigens; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1967 |
Induced susceptibility of sheep to carbon tetrachloride intoxication.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1967 |
[Lipoprotein biosynthesis in the liver in various conditions].
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In Vitro Tec | 1967 |
The role of the liver in the development of hypercholesterolaemia in atherosclerosis.
Topics: Animals; Aorta; Arteriosclerosis; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced L | 1967 |
Serum gamma-glutamyl transpeptidase activity in healthy cats and cats with induced hepatic disease.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Cat Diseases; Cats; Chemi | 1983 |
Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatotoxicity.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Inter | 1980 |
Potentiation of CCl4 lethality by chlordecone.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Synergism; | 1982 |
Effect of cortisone on the behavior of serotonin, 5-hydroxy-indoloacetic acid and monoaminooxidase in the liver tissue, the blood and the urine in experimental rabbit liver injury with CCl4.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cortisone; Hydroxyindoleaceti | 1982 |
Nuclear magnetic resonance imaging of experimentally induced liver disease.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethionine; Humans; Iron; Iron | 1983 |
Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: a light and electron microscopic study.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlordecone; Cy | 1983 |
Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: a morphometric and biochemical study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Nucleus; Chem | 1983 |
Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease | 1983 |
[Experimental and clinical studies on enzymes of mitochondria in various liver diseases; with special reference to alcoholic liver disease (author's transl)].
Topics: 1-Naphthylisothiocyanate; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and D | 1980 |
The damage of the hepatic mixed functional oxygenase system by CCl4: significance of incorporation of 14CCl4 metabolites in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Choleca | 1982 |
Free radical formation in vivo and hepatotoxicity due to anesthesia with halothane.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclic N-Oxides; Electron Spi | 1982 |
Carbon tetrachloride-induced liver injury in the rabbit.
Topics: Animals; Arachidonic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome | 1983 |
[Effects of cianidanol (KB-53) on experimental liver injury in mice--histopathological, histochemical and enzyme-histochemical studies].
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Benzopyrans; Carbon Tetrachloride; Catechin | 1983 |
Effects of medroxyprogesterone acetate on hepatic glucose metabolism and microsomal enzyme activity in rats with normal and altered liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1984 |
Effect of realimentation after several days' pure carbohydrate intake on DNA synthesis in regenerating rat liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diet; Dietary Carbohydrates; | 1980 |
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; C | 1984 |
Protection of hepatocytes with hyperoxia against carbon tetrachloride-induced injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachlori | 1984 |
Studies on the mechanism of glutathione prevention of carbon tetrachloride-induced liver injury.
Topics: Animals; Arachidonic Acids; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1983 |
Strain differences in mice in carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Glycocholic Acid; Liv | 1983 |
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; | 1983 |
Genetics of carbon tetrachloride-induced liver injury in mice. II. Multigenic regulation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Genotype; Glycocholic | 1984 |
Late preventive effects of phenylmethylsulfonyl-fluoride on carbon tetrachloride-induced liver necrosis.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1984 |
Free radicals in vivo. Covalent binding to lipids.
Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1984 |
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1981 |
[Studies on comprehensive evaluation of toxic liver injury (author's transl)].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hematolo | 1981 |
Clearance of lactate dehydrogenase by SJL/J mice infected with lactate dehydrogenase-elevating virus.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; L-Lactate Dehydrogena | 1983 |
Biliary excretion of antibiotics in rats.
Topics: Animals; Anti-Bacterial Agents; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1983 |
Effect of an acute dose of ethanol on the hepatotoxicity due to carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1983 |
Sensitivity of serum glutamic oxaloacetic transaminase and bile acid levels for the detection of experimental liver injury in rats.
Topics: Animals; Aspartate Aminotransferases; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug | 1981 |
Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Immunity, Cellular; Liver; Li | 1980 |
Acute effects of selected hepatotoxic agents on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Acute Disease; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug | 1982 |
Possible role of lipid peroxidation in the actions of acrylonitrile on the adrenals, liver and gastrointestinal tract.
Topics: Acrylonitrile; Adrenal Gland Diseases; Animals; Carbon Tetrachloride; Chemical and Drug Induced Live | 1982 |
[Changes in the anti-heparin activity of platelet-free plasma in rats with induced inflammation and after administration of CC14 (author's transl)].
Topics: Animals; Blood Coagulation Factors; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In | 1982 |
Plasma lipoprotein pattern in relation to liver histology after toxic hepatitis and experimental biliary obstruction in rabbits.
Topics: Alanine Transaminase; Allylisopropylacetamide; Animals; Aspartate Aminotransferases; Carbon Tetrachl | 1982 |
Hepatotoxicity of trichloroethylene-carbon tetrachloride mixtures in rats. A possible consequence of the potentiation by trichloroethylene of carbon tetrachloride-induced lipid peroxidation and liver lesions.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Lipid Metabolism | 1982 |
[Effect of crude drugs on experimental liver damages I. The active principle of Zedoariae Rhizoma (author's transl)].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; | 1982 |
[Effect of exogenous RNA on the regenerating activity of the liver after partial hepatectomy and after damage of the hepatic tissue by tetrachloromethane].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatectomy; Liver Diseases; | 1982 |
[Changes in the alkaline phosphatase activity and properties of the blood serum in sheep with experimental liver disease].
Topics: Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme | 1980 |
Studies on the prevention of CCl4 induced liver necrosis by agents having effects on cell membrane.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; | 1980 |
The protection of coenzyme Q10 against carbon tetrachloride hepatotoxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induc | 1981 |
[Mechanisms of the retabolil restoration of liver functions in a toxic lesion from tetrachloromethane].
Topics: Anabolic Agents; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Evaluat | 1981 |
Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Guanine; Liver Extracts; | 1981 |
The effect of dibutyl sulphide on hepatocytes studied by means of the isolated rat liver perfusion after preceding exposure to tetrachloromethane and phenobarbital in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Perfus | 1981 |
[Morphological studies on the protective effect of small doses of carbon tetrachloride on the rat liver].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D | 1980 |
Attachment to collagen by isolated hepatocytes from rats with induced hepatic fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion; Chemical and Drug Induced Liver Injury; Collagen; Live | 1980 |
Serum bile acid concentration in some experimental liver lesions of rat.
Topics: Alanine Transaminase; Aniline Compounds; Animals; Bile Acids and Salts; Bile Ducts; Carbon Tetrachlo | 1980 |
Cell-mediated immunity to liver antigen in toxic liver injury. I. Occurrence and specificity.
Topics: Animals; Antigens; Carbon Tetrachloride; Cell Migration Inhibition; Chemical and Drug Induced Liver | 1980 |
Increased susceptibility of rabbits to intravenous challenge with Mycobacterium avium after mild hepatitis produced by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Mycobacterium avium; O | 1980 |
Two rapid methods for the simultaneous gas-liquid chromatographic determination of carbon tetrachloride and chloroform in biological material and expired air.
Topics: Air; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform | 1980 |
The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Ehrlich Tumor; Chemical and Drug Induced Liver Injury; Cyc | 1980 |
Pyrazole prevention of CC14-induced ultrastructural changes in rat liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Glutat | 1980 |
Effect of fasting, diethyl maleate, and alcohols on carbon tetrachloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 1980 |
[Influence of pretreatment with carbon tetrachloride on paracetamol-induced hepatotoxicity].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1980 |
Tumor necrosis factor-alpha and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Arginine; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical | 1995 |
Effect of carbon tetrachloride intoxication and ethanol ingestion on interferon production in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1994 |
Sulfatide, a specific sugar ligand for L-selectin, blocks CCl4-induced liver inflammation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Adhesion; Cel | 1995 |
Impaired glucose uptake and intact gluconeogenesis in perfused rat liver after carbon tetrachloride injury.
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gluconeogenesi | 1995 |
Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 1995 |
Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Liver; Mic | 1995 |
[Evaluation of hepatic blood flow using 99mTc-GSA in rats with hepatic blood flow manipulation].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatic Artery; Ligation; Liv | 1995 |
Preventive effect of dai-saiko-to (da-chai-hu-tang) extract on disrupted hepatic active oxygen metabolism in rats with carbon tetrachloride-induced liver injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartic Acid; Carbon Tetrachloride; Chemical a | 1995 |
Anti-inflammatory and hepatoprotective effects of Solanum alatum.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carrageenan; Chemi | 1995 |
[Protective effects of the stem of Berchemia racemosa Sieb. et Zucc. on experimental liver injuries].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cho | 1995 |
Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents.
Topics: Alanine Transaminase; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 1994 |
Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; F | 1995 |
Preventive effect of taraxasteryl acetate from Inula britannica subsp. japonica on experimental hepatitis in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; Inula; Liver F | 1995 |
Exacerbation of carbon tetrachloride-induced liver injury in the rat by methamphetamine.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Carbon Tetrachloride; Chemical and Drug Induced | 1995 |
Protective effects of the nucleic acid components on CCL4-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1994 |
Changes in the virulence of Mycobacterium bovis (BCG Phipps) in carbon tetrachloride treated mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Male; Mice; Mycobacte | 1994 |
In vivo correlation between liver and blood energy status as evidenced by chronic treatment of carbon tetrachloride and adenosine to rats.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood; C | 1994 |
Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin.
Topics: Amino Acid Sequence; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1993 |
Effect of ursodeoxycholic acid on in vivo and in vitro toxic liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Car | 1994 |
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Topics: 1-Propanol; Acetaminophen; Animals; Cadmium; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1994 |
In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl4-induced hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Edema; Kupffer Cells; Liver D | 1994 |
Hepatoprotective effects of Taiwan folk medicine: wedelia chinensis on three hepatotoxin-induced hepatotoxicity.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotr | 1994 |
[The effect of chorionic gonadotropin on normalization of lipid peroxidation].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Lipid | 1994 |
[The effect of chorionic gonadotropin on lactate dehydrogenase and alcohol dehydrogenase in pathologically changed liver].
Topics: Alcohol Dehydrogenase; Animals; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Inj | 1994 |
Protective effect of Trionyx carapax on CCl4-induced hepatic injury is mediated by uracil.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1994 |
Protection of carbon tetrachloride hepatotoxicity by cinchona alkaloids.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Carbon Tetrachloride; Chemical and | 1994 |
Effects of liver damage induced by carbon tetrachloride on glutathione and glutathione-dependent enzymes in rat gastric mucosa.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; gamma-Glutamyltransferase; Ga | 1993 |
Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Carboxylic Es | 1993 |
Cytoprotective effect of prostaglandin E2 and I2 in experimental liver damage.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dinoprostone; Epoprostenol; L | 1994 |
Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents.
Topics: Administration, Inhalation; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetra | 1993 |
Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis.
Topics: Animals; Body Temperature; Calcium; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug In | 1993 |
Effect of antimitotic agent colchicine on carbon tetrachloride toxicity.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Biotransformation | 1993 |
Ca-efflux, from direct membrane injury by CCl4, is elicited by amphiphilic vehicles in vitro.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Electron Spin Resona | 1993 |
Effects of alcohol, carbon tetrachloride, and choline deficiency on iron metabolism in the rat.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Choline Deficiency; Ethanol; | 1993 |
Granuloma formation in the liver of Balb/c mice intoxicated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Desmin; Granuloma; Immunoenzy | 1993 |
Effects of mild zinc deficiency, plus or minus acute phase response, on CCl4 hepatotoxicity.
Topics: Acute-Phase Reaction; Animals; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver | 1994 |
Protective effect of dantrolene sodium on carbon tetrachloride induced liver injury in the rat.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1993 |
Pharmacokinetics of indocyanine green in rats with experimentally induced hepatic diseases.
Topics: Acute Disease; Animals; Bile; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1993 |
Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 1993 |
Pharmacological and pathological studies on Taiwan folk medicine (IX): The hepatoprotective effect of the methanolic extract from echinops grijisii.
Topics: 1-Butanol; Acetates; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biopsy; Butanols; C | 1993 |
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; | 1993 |
Biochemical and morphological studies on the effects of anthocyans and vitamin E on carbon tetrachloride induced liver injury.
Topics: Alanine Transaminase; Animals; Anthocyanins; Antioxidants; Aspartate Aminotransferases; Carbon Tetra | 1993 |
Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical and Drug Induced | 1993 |
Protective effects of tetrahydroneopterin against free radical-induced injury.
Topics: Animals; Biopterins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Doxorubicin; Edem | 1993 |
Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: comparison with carbon tetrachloride.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Interacti | 1993 |
Determination of 4-hydroxynonenal by high-performance liquid chromatography with electrochemical detection.
Topics: Aldehydes; Animals; Bromobenzenes; Bromotrichloromethane; Carbon Tetrachloride; Cell Line; Chemical | 1993 |
Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Carbon Tetrachloride; Chemical and Dr | 1993 |
Combined effects of streptozotocin-induced diabetes plus 4-methylpyrazole treatment on rat liver cytochrome P4502E1.
Topics: Animals; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 C | 1993 |
Characterization of vitamin A potentiation of carbon tetrachloride-induced liver injury.
Topics: 1-Propanol; Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug In | 1993 |
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: enhanced lipid peroxidation without enhanced biotransformation.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Li | 1993 |
Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injur | 1993 |
Volatile organic solvents in correction fluids: identification and potential hazards.
Topics: Adolescent; Carbon Tetrachloride; Central Nervous System Diseases; Chemical and Drug Induced Liver I | 1993 |
Effect of hepatoprotective ayurvedic drugs on lipolytic activities during CCl4 induced acute hepatic injury in albino rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; India; Lipase; Liver; Liver D | 1993 |
Elevation of cystathionine gamma-lyase activity in the serum of rats treated with a single dose of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cystathionine gamma-Lyase; Li | 1995 |
Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature Regulation; Calmodulin; Carbon Tetrachloride; Chemical and Drug Induced Li | 1995 |
Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Gadolinium; L | 1995 |
Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice.
Topics: 1-Propanol; Administration, Oral; Allyl Compounds; Animals; Antioxidants; Carbon Tetrachloride; Cell | 1995 |
Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Epidermal | 1996 |
[Protective effects of liu tea on CCl4 injured liver and its working mechanism].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1995 |
Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Histamine; Histidine Decarbox | 1996 |
The nature and significance of liver cell vacuolation following hepatocellular injury--an analysis based on observations on rats rendered tolerant to hepatotoxic damage.
Topics: Adaptation, Physiological; Aflatoxin B1; Alanine Transaminase; Animals; Aspartate Aminotransferases; | 1996 |
Methanol potentiation of carbon tetrachloride hepatotoxicity: the central role of cytochrome P450.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syste | 1996 |
Histopathological evaluation on the effect of red propolis on liver damage induced by CCl4 in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1996 |
Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Galactosa | 1996 |
Prolonged decrease in hepatic connexin32 in chronic liver injury induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Blotting, Northern; Carbon Tetrachloride; Cell Division; Chemical and | 1996 |
[Expression and significance of PKC alpha in regenerating liver of rats after partial hepatectomy and CCl4 administration].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatectomy; Immunohistochemi | 1996 |
[Stimulation of regenerative processes and correction of the functional activity of the liver in its partial resection and toxic lesions].
Topics: Animals; Anti-Bacterial Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; G | 1996 |
Differential expression of cysteine-rich intestinal protein in liver and intestine in CCl4-induced inflammation.
Topics: Animals; Carbon Tetrachloride; Carrier Proteins; Chemical and Drug Induced Liver Injury; Diet; Immun | 1996 |
Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721).
Topics: Alkaline Phosphatase; Amifostine; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1995 |
Further evidence for zinc as a hepatoprotective agent in rat liver toxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Lipid Peroxidati | 1995 |
Dose- and route-dependent alterations in metabolism and toxicity of chemical compounds in ethanol-treated rats: difference between highly (chloroform) and poorly (carbon tetrachloride) metabolized hepatotoxic compounds.
Topics: Administration, Inhalation; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug I | 1997 |
Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis; Dise | 1997 |
Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Galact | 1997 |
Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Ch | 1997 |
Effect of Emulphor, an emulsifier, on the pharmacokinetics and hepatotoxicity of oral carbon tetrachloride in the rat.
Topics: Administration, Oral; Alanine Transaminase; Animals; Area Under Curve; Carbon Tetrachloride; Chemica | 1997 |
Evaluation of four prescriptions of traditional Chinese medicine: syh-mo-yiin, guizhi-fuling-wan, shieh-qing-wan and syh-nih-sann on experimental acute liver damage in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1997 |
Pre- and postprandial total serum bile acid concentration following acute liver damage in dogs.
Topics: Acute Disease; Animals; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1997 |
Enhancement of lipid peroxidation in the liver of mice exposed to magnetic fields.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Electromagnetic Fields; Lipid | 1997 |
Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; C | 1996 |
Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: effect of astilbin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced | 1997 |
Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo.
Topics: Administration, Oral; Animals; Biological Assay; Carbon Tetrachloride; Cataract; Chemical and Drug I | 1997 |
Abnormal expressions of hepatocellular proteins and extracellular matrix in CCL4-induced liver injury in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Extracellular Matr | 1996 |
alpha-Tocopheryl hemisuccinate administration increases rat liver subcellular alpha-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1997 |
The effect of aflatoxin B1 on the expression of early response genes and transforming growth factor-alpha in CCl4 induced rat liver injury.
Topics: Aflatoxin B1; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug Induced Liver Injury; Ge | 1997 |
Cytosolic NADPH-UQ reductase-linked recycling of cellular ubiquinol: its protective effect against carbon tetrachloride hepatotoxicity in rat.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Liver; Male; Microso | 1997 |
Hepatic ultrasonographic findings in experimental carbon tetrachloride intoxication of the dog.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tetrachloride; Chemical a | 1997 |
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooc | 1997 |
Gene expression in liver after toxic injury: analysis of heat shock response and oxidative stress-inducible genes.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA-Binding Proteins; Ferriti | 1997 |
Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: effects of insulin and Schisandrin B treatment.
Topics: Alanine Transaminase; Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride; Chemical and Drug | 1997 |
Zeaxanthin dipalmitate from Lycium chinense has hepatoprotective activity.
Topics: Animals; beta Carotene; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Indu | 1997 |
Curative effects of mandur bhasma on liver and kidney of albino rats after induction of acute hepatitis by CCl(4).
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Kidney; Liver; Male; Medicine | 1997 |
Protection against hepatotoxicity by a single dose of amphetamine: the potential role of heat shock protein induction.
Topics: Acetaminophen; Amphetamine; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced | 1997 |
Esculetin prevents liver damage induced by paracetamol and CCL4.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1998 |
Green tea suppresses D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1998 |
Gamma-glutamylcysteinylethyl ester attenuates progression of carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1998 |
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bil | 1998 |
Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DN | 1998 |
The recovering effect of betaine on carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Betaine; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induce | 1998 |
Inhibitory effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on hepatic triglyceride accumulation with the progression of carbon tetrachloride-induced acute liver injury in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Ulcer Agents; Aspartate Aminotransferases; | 1998 |
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagenases; Gene | 1998 |
Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Blood Urea Nitrogen; Bromobenzenes; Carbon | 1998 |
Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Animals; Carbon Tetrachloride; Chemical and Drug In | 1998 |
Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality.
Topics: Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Chlordecone; C | 1998 |
Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride.
Topics: Animals; Arginine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Drug Inte | 1998 |
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Topics: Animals; Biliary Tract; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1998 |
Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Betaine; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced | 1998 |
Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Movement; Chemical and Drug Induced Liver Injury; | 1998 |
Mechanism of the protective effects of sumac gall extract and gallic acid on the progression of CCl4-induced acute liver injury in rats.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Animals; Carbon Tetrachloride; Chem | 1998 |
Effect of pretreatment of rats with an urinary preparation on liver injuries induced by carbon tetrachloride and alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 1998 |
Hepatoprotective activity of scopoletin, a constituent of Solanum lyratum.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Live | 1998 |
Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression.
Topics: Animals; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induce | 1998 |
TA1 oncofetal rat liver cDNA and putative amino acid permease: temporal correlation with c-myc during acute CCl4 liver injury and variation of RNA levels in response to amino acids in hepatocyte cultures.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Carbon Tetrachloride; Cell Survival; Cells, Cult | 1999 |
Endogenous glucocorticoids released during acute toxic liver injury enhance hepatic IL-10 synthesis and release.
Topics: Acute Disease; Adrenalectomy; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1999 |
Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair.
Topics: Animals; Carbon Tetrachloride; Cell Adhesion Molecules; Cells, Cultured; Chemical and Drug Induced L | 1999 |
Oxidative injury induced cyclooxygenase activation in experimental hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dinoprost; Enzyme Activation; | 1999 |
Effect of central corticotropin-releasing factor on carbon tetrachloride-induced acute liver injury in rats.
Topics: Acute Disease; Animals; Atropine; Brain; Carbon Tetrachloride; Chemical and Drug Induced Liver Injur | 1999 |
Liver-protective activities of aucubin derived from traditional oriental medicine.
Topics: Amanita; Animals; Antiviral Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Do | 1998 |
Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Li | 1999 |
Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1999 |
Nitric oxide increases hepatic arterial blood flow in rats with carbon tetrachloride-induced acute hepatic injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inhibit | 1999 |
Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries.
Topics: Alanine Transaminase; Aniline Hydroxylase; Animals; Antioxidants; Aspartate Aminotransferases; Bepri | 1999 |
The protective action of thymol against carbon tetrachloride hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Antioxidants; Butylated Hydroxytoluene; Carbon | 1999 |
Astilbin selectively induces dysfunction of liver-infiltrating cells--novel protection from liver damage.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA | 1999 |
Development of a hepatocyte-specific prostaglandin E(1) polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dinoprostone; | 1999 |
Effects of dietary polyunsaturated fatty acids and nucleotides on tissue fatty acid profiles of rats with carbon tetrachloride-induced liver damage.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Fats; Fatty Acids; Li | 1999 |
Evaluation of hepatoprotective activity of Cassia fistula leaf extract.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 1999 |
Susceptibility to chlordecone-carbon tetrachloride induced hepatotoxicity and lethality is both age and sex dependent.
Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemi | 1999 |
Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Tetrachloride; Cell Division; Cell Mov | 1999 |
Hepatoprotective action of adenovirus-transferred HNF-3gamma gene in acute liver injury caused by CCl(4).
Topics: Acute Disease; Adenoviridae; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1999 |
Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 1999 |
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DNA-B | 2000 |
Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Carbon Tetrachloride | 1999 |
Low-dose gamma-ray irradiation reduces oxidative damage induced by CCl4 in mouse liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1999 |
Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glucuronid | 2000 |
Differential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury.
Topics: Activin Receptors; Activins; Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced | 2000 |
Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; In | 2000 |
Antioxidant and hepatoprotective actions of the medicinal herb Artemisia campestris from the Okinawa Islands.
Topics: Animals; Antioxidants; Artemisia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Free | 2000 |
Rifampicin suppresses hepatic CYP2E1 expression and minimizes DNA injury caused by carbon tetrachloride in perivenular hepatocytes of mice.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome | 2000 |
Protective effect of curcumin in rat liver injury induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; | 2000 |
Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbon Tetrachloride; Chemical and D | 2000 |
Protective effects of seaweeds against liver injury caused by carbon tetrachloride in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, | 2000 |
Interaction of albumin mRNA with proteins from rat liver with CCl(4)-induced injury.
Topics: Acute-Phase Reaction; Albumins; Amanitins; Animals; Base Sequence; Binding, Competitive; Carbon Tetr | 2000 |
Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzoquinones; Carbon Tetrachloride; Che | 2000 |
Carbon tetrachloride treatment induces anorexia independently of hepatitis in rats.
Topics: Animals; Anorexia; Appetite Regulation; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced | 2000 |
Platelet-endothelial cell adhesion molecule-1 gene expression in liver sinusoidal endothelial cells during liver injury and repair.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endothelium, Vascular; Gene E | 2000 |
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemic | 2000 |
Targeted delivery of prostaglandin E1 to hepatocytes using galactosylated liposomes.
Topics: Alanine Transaminase; Alprostadil; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 2000 |
FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; | 2000 |
Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Male; | 2000 |
Decrease of platelet-endothelial cell adhesion molecule 1-gene-expression in inflammatory cells and in endothelial cells in the rat liver following CCl(4)-administration and in vitro after treatment with TNFalpha.
Topics: Animals; Carbon Tetrachloride; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Endo | 2000 |
Yang-Gan-Wan protects mice against experimental liver damage.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models | 2000 |
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
Topics: Acetaminophen; Animals; Antioxidants; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Li | 2000 |
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.
Topics: 1-Naphthylisothiocyanate; Aminophenols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liv | 2000 |
Liver resistance to CCl(4)-induced injury after stimulation of macrophages with various preparations.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induc | 2000 |
Liver resistance to toxic effects of CCl(4) under conditions of gadolinium chloride depression of Kupffer cells.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gadolinium; Kupffer Cells; Li | 2000 |
Hepatoprotective effects of Turkish folk remedies on experimental liver injury.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2000 |
Effect of liquid extract from fresh Abutilon indicum leaves and Allium cepa bulbs on paracetamol and carbontetrachloride induced hepatotoxicity.
Topics: Acetaminophen; Allium; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride; Chemical and Drug In | 2000 |
Antioxidant and hepatoprotective effects of Acathopanax senticosus.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetr | 2000 |
Three-dimensional observations of spatial arrangement of hepatic zonation and vein system in mice and house musk shrews.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Di | 2000 |
The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2000 |
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
Topics: Albumins; Animals; Anthraquinones; Antineoplastic Agents; Aspartate Aminotransferases; Blotting, Nor | 2000 |
Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary | 2001 |
Ampelopsis brevipedunculata (Vitaceae) extract inhibits a progression of carbon tetrachloride-induced hepatic injury in the mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs | 2000 |
Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1(I) and alpha1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs.
Topics: Acute-Phase Reaction; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collage | 2001 |
Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice.
Topics: Acute Disease; Animals; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2001 |
[The protective effect of hepatocyte growth-promoting factor (pHGF) against carbon tetrachloride-induced acute liver injury in rats. II. Protective effects on cell membrane injury].
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cel | 2001 |
Carbon tetrachloride-induced acute liver injury in Mini and Wistar rats.
Topics: Alkaline Phosphatase; Animals; Animals, Genetically Modified; Apoptosis; Aspartate Aminotransferases | 2001 |
Hepatoprotective activity of Luffa echinata fruits.
Topics: Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Animals; Aspartate Aminotransferas | 2001 |
Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury.
Topics: Animals; Carbon Tetrachloride; cdc25 Phosphatases; Cell Adhesion Molecules; Cell Cycle Proteins; Che | 2001 |
Kinetics and mechanisms of hepatic acute phase response to subtotal partial hepatectomy and cultural impact on environmental hepatic end-stage liver injury in the homeless.
Topics: Acute-Phase Reaction; Aflatoxin B1; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2001 |
Hepatoprotective activity of indigtone--a bioactive fraction from Indigofera tinctoria Linn.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fabaceae; Female; Hepatocytes | 2001 |
The role of Smad3 in mediating mouse hepatic stellate cell activation.
Topics: Actins; Animals; Carbon Tetrachloride; Cattle; Cell Division; Cells, Cultured; Chemical and Drug Ind | 2001 |
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ber | 2000 |
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Carbon Tetrachloride; Carcinogens; Chemical a | 2001 |
Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical a | 2001 |
The usefulness of antioxidative enzymes for the estimation of synthetic effects of PGE1 analogue.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Combinatio | 2001 |
Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Cata | 2001 |
Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Flavanones; | 2001 |
Effect of central urocortin on carbon tetrachloride-induced acute liver injury in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; Carbon Tetrachlori | 2001 |
Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat.
Topics: Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorzox | 2001 |
Induction of hepatic tissue-type plasminogen activator and type 1 plasminogen activator-inhibitor gene expressions and appearance of their translation products in the bile following acute liver injury in rats.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 2001 |
Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury.
Topics: Afibrinogenemia; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Dise | 2001 |
Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Extracellular Matr | 2001 |
The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2001 |
Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Division; Cell Line; Cells, Cultured; Chemical an | 2002 |
Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action.
Topics: Alkyl and Aryl Transferases; Animals; Benzopyrans; Carbon Tetrachloride; Cell Line; Cell Survival; C | 2002 |
[Expression of eNOS and IL-10 gene in signal transduction for liver regeneration].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Flow Cytometry; Gene Exp | 1998 |
Hepatoprotective action of abhrak bhasma, an ayurvedic drug in albino rats against hepatitis induced by CCl4.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Lipoprotein Lipase; Liver; Ma | 2001 |
Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Electro | 2002 |
Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dos | 2002 |
Involvement of endogenous CRF in carbon tetrachloride-induced acute liver injury in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Atropine Derivatives; Carbon Tetrachloride; Chemical a | 2002 |
Mast cell density: a quantitative index of acute liver inflammation.
Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell | 2002 |
Free radical scavenging action of the medicinal herb Limonium wrightii from the Okinawa islands.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2002 |
Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl(4)-induced toxicity: action mechanism and structure-activity relationship.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cinnamates; | 2002 |
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Diab | 2002 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; C | 2002 |
Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in the alleviation of carbon tetrachloride-induced acute hepatotoxicity in the rat.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Evaluatio | 2002 |
Use of plasma arginase and gamma-glutamyl transpeptidase as specific indicators of heptocellular or hepatobiliary disease in the dog.
Topics: Animals; Arginase; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Extrah | 1979 |
Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.
Topics: alpha-Fetoproteins; Aminoacetonitrile; Animals; Carbon Tetrachloride; Chemical and Drug Induced Live | 1976 |
Potentiation of the hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (kepone) in the male rat.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Synergism; | 1979 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1975 |
Protection by propylthiouracil against carbon tetrachloride-induced liver damage.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1976 |
Relationship between lysosomal damage, fatty infiltration and hepatocellular necrosis in the course of acute liver injury induced by carbon tetrachloride in the rat.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1975 |
[Enzyme values of 2 liver homogenates in liver diseases].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Histocytochemistry; | 1977 |
Hepatotoxicity of o-ethyl-S-(2-dimethylaminoethyl) methylphosphonothioate in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Female; Liver; Organ | 1977 |
[Studies on the endocrine function of the pancreas with special regard to the alpha cell in subjects with various liver diseases. Part II Changes of plasma glucagon and insulin level in response to arginine treatment in rats with liver disorders induced b
Topics: Animals; Arginine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced L | 1977 |
[Changes of the regenerative activity of the liver damaged by tetrachlorome thane following previous administration of E.coli endotoxin].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endotoxins; Escherichia coli; | 1978 |
Modification of carbon tetrachloride hepatotoxicity by chemicals.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1977 |
Comparison of in vivo and in vitro drug metabolism in experimental hepatic injury in the rat.
Topics: Acetaminophen; Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Carbon Dioxide; Carbon | 1979 |
Halothane hepatotoxicity and fluoride production in mice and rats.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; | 1979 |
The mechanism of necrotic tissue removal in mouse liver following CCl4-induced injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximide; Eosinophils; L | 1979 |
Liver-protective principle of Thujopsis dolabrata leaves.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Japan; Liver; Mice; Plant Ext | 1979 |
[Analysis of radiorespirometric pattern in rats bearing liver injury treated with CCl4 (author's transl)].
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1979 |
Possible role of a new metal chelate in the treatment of carbon tetrachloride induced liver damage in squirrels.
Topics: Animals; Carbon Tetrachloride; Chelating Agents; Chemical and Drug Induced Liver Injury; Liver Disea | 1979 |
[Influence of different regimens of intermittent carbon tetrachloride action of the development of the hepatotoxic effect].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Hepatotoxicity of carbon tetrachloride in developing rats.
Topics: Acetoacetates; Aging; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1979 |
Protection of carbon tetrachloride-induced hepatotoxicity by zinc: role of metallothionein.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Potentiation of CCl4 hepatotoxicity in rats by a metabolite of 2-butanone: 2,3-butanediol.
Topics: Alanine Transaminase; Animals; Butanones; Butylene Glycols; Carbon Tetrachloride; Chemical and Drug | 1979 |
Influence of aliphatic alcohols on the hepatic response to halogenated olefins.
Topics: Alcohols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Sy | 1977 |
Drugs and what they do to the liver.
Topics: Adrenal Cortex Hormones; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Huma | 1978 |
Carbon tetrachloride activation, lipid peroxidation and liver necrosis in different strains of mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Lipid Me | 1978 |
Development of resistance to hepatotoxic effect of furylfuramide by pretreatment with its subnecrotic doses and carbon tetrachloride.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride; | 1978 |
Radioimmunoassay of plasma ligandin: a sensitive index of experimental hepatocellular necrosis.
Topics: Animals; Aspartate Aminotransferases; Blood Specimen Collection; Carbon Tetrachloride; Carbon Tetrac | 1978 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
Alanine aminotransferase (GPT) in rainbow trout: plasma enzyme levels as an index of liver damage.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1977 |
Studies on the role of protein syntheis in cell injury by toxic agents: I. Effect of cycloheximide administration on several factors modulating carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximi | 1977 |
Liver endoplasmic reticulum: target site of halocarbon metabolites.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Retic | 1977 |
Evidence for carbon tetrachloride- and ethanol-induced lipid peroxidation in vivo demonstrated by ethane production in mice and rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethane; Ethanol; Lipid Metabo | 1977 |
Effect of different factors modifying the activity of some enzyme systems of the endoplastic reticulum on the sensitivity of cell organelles against the damaging action of chemical agents. I: Interrelations between the activity of some enzyme systems loca
Topics: Acid Phosphatase; Aniline Hydroxylase; Animals; Burns; Carbon Tetrachloride; Chemical and Drug Induc | 1976 |
Quantitative aspects in the assessment of liver injury.
Topics: 1-Propanol; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1976 |
Mechanistic studies on carbon tetrachloride hepatoxicity in fasted and fed rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1975 |
Effects of chlordane pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordan; Cytochrome P-450 En | 1975 |
The effect of a dose of dimethylnitrosamine on the toxicity of a subsequent dose and on the toxicity of carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drug Int | 1975 |
Species differences in carbon tetrachloride-induced hepatotoxicity: the role of CCl4 activation and of lipid peroxidation.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1975 |
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature; | 1975 |
Manganese induced hepatic lesions in carbon tetrachloride pretreated rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 1975 |
Distribution and cellular origin of undulin in rat liver.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Adhesion Molecules, Neuronal; Chemical and Drug Induced | 1992 |
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Cell Size; Chemical and Drug Induced Liver Injury; C | 1992 |
[Effect of the root of Polygonum multiflorum Thunb. and its processed products on fat accumulation in the liver of mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Hot Te | 1992 |
Spin trapping of free radical metabolites of carbon tetrachloride in vitro and in vivo: effect of acute ethanol administration.
Topics: Animals; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induce | 1992 |
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.
Topics: Animals; Carbon Disulfide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome | 1992 |
Arachidonate metabolism in D-galactosamine or carbon tetrachloride-induced acute and chronic liver injuries in rats.
Topics: Acute Disease; Animals; Arachidonic Acids; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1992 |
Effect of adenosine 3',5'-cyclic monophosphate derivatives on acute liver injury induced by carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1992 |
Changes in DNA strand breaks in non-parenchymal cells following hepatocyte regeneration in CCl4-induced rat liver injury.
Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Liver | 1992 |
[Mechanisms of protective action of radix Salviae miltiorrhizae (RSM) against experimental hepatic injury in rats].
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P | 1992 |
The fate of collagen during experimental liver lesion with carbon tetrachloride in the presence and absence of colchicine.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Colchicine; Collagen; Female; | 1992 |
Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Proteins; Ca | 1992 |
[Effects of astragalus (ASI, SK) on experimental liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1992 |
Pharmacological and pathological studies on hepatic protective crude drugs from Taiwan (V): The effects of Bombax malabarica and Scutellaria rivularis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1992 |
Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis.
Topics: Actins; Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Desmin | 1992 |
Distribution of quinidine in rats with carbon tetrachloride-intoxicated hepatic disease.
Topics: Animals; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hydrogen-Ion | 1992 |
Comparison of the protective effect of Withaferin-'A' and hydrocortisone against CCL4 induced hepatotoxicity in rats.
Topics: Alkaline Phosphatase; Animals; Blood Proteins; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1992 |
Macrophage and perisinusoidal cell kinetics in acute liver injury.
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Carbon Tetrachloride; Chemical and Drug Induced | 1992 |
Effects of ethanol and carbon tetrachloride upon vitamin A status of rats.
Topics: Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1992 |
Protective effect of oral acetylcysteine against the hepatorenal toxicity of carbon tetrachloride potentiated by ethyl alcohol.
Topics: Acetylcysteine; Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; C | 1992 |
Immunolocalization of proliferating perisinusoidal cells in rat liver.
Topics: Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Desmin; DNA; I | 1992 |
[A study of the protective mechanism of hepatic stimulator substance against experimental acute liver failure in mice].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Growth Substance | 1992 |
Studies on folk medicine "thang-kau-tin" from Taiwan. (I). The anti-inflammatory and liver-protective effect.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carrageenan; Chemi | 1992 |
Prevention of carbon tetrachloride-induced liver necrosis by the chelator alizarin sodium sulfonate.
Topics: Animals; Anthraquinones; Body Temperature; Calcium; Carbon Tetrachloride; Chelating Agents; Chemical | 1992 |
Effect of olean-9(11), 12-diene-3 beta, 30-diol 3 beta, o-hemisuccinate Na salt, a glycyrrhetinic acid derivative, on peroxidation in CCl4 induced mouse acute hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1991 |
Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Induction; Extracellul | 1991 |
Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride-treated rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 1991 |
Carbon tetrachloride-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Calmodulin; Carbon Tetrachlorid | 1991 |
Biochemical assessment of the genotoxicity of the in vitro interaction between chlordecone and carbon tetrachloride in rat hepatocytes.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; DNA Damage; Live | 1991 |
Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 1991 |
Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1991 |
Evaluation of root quality of Bupleurum species by TLC scanner and the liver protective effects of "xiao-chai-hu-tang" prepared using three different Bupleurum species.
Topics: Animals; Calibration; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, | 1991 |
Investigations on the sensitivity of several biochemical and histological methods after liver intoxication induced by pentachlorophenol and carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; L | 1991 |
[Pharmacological study on anti-hepatitis effect of Cotinus coggygria Scop. Syrup].
Topics: Animals; Antibody Formation; Antiviral Agents; Bile; Carbon Tetrachloride; Chemical and Drug Induced | 1991 |
Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzazepines; Carbon Tetrachloride; Chem | 1991 |
Effects of small-intestinal factors on hepatocyte development and modification of chemical agent-induced hepatopathy in rat.
Topics: Animals; Biological Factors; Carbon Tetrachloride; Cell Count; Cells, Cultured; Chemical and Drug In | 1991 |
Identification and change in the receptor for hepatocyte growth factor in rat liver after partial hepatectomy or induced hepatitis.
Topics: Animals; Carbon Tetrachloride; Cell Membrane; Cells, Cultured; Chemical and Drug Induced Liver Injur | 1991 |
Free radical-induced liver injury. II. Effects of intraperitoneally administered 2,2'-azobis(2-amidinopropane) dihydrochloride on the fatty acid profiles of hepatic triacylglycerol and phospholipids.
Topics: Amidines; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Acids; Free R | 1991 |
Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Carbon Tetr | 1991 |
Temporal and spatial patterns of proto-oncogene expression at early stages of toxic liver injury in the rat.
Topics: Animals; Antibodies, Monoclonal; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gene | 1991 |
The pharmacological and pathological studies on Taiwan folk medicine (VI): The effects of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1991 |
Protective effects of misoprostol on carbon tetrachloride-induced liver damage in the rat.
Topics: Alprostadil; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced L | 1991 |
[Studies on warming the middle-jiao and analgesic effect of flos Caryophylli].
Topics: Analgesics; Animals; Anti-Ulcer Agents; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1991 |
Ethanol and food deprivation induced enhancement of hepatotoxicity in rats given carbon tetrachloride at low concentration.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; | 1991 |
Kupffer cells from carbon tetrachloride-injured rat livers produce chemotactic factors for fibroblasts and monocytes: the role of tumor necrosis factor-alpha.
Topics: Animals; Antibodies; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; | 1991 |
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; Aflatoxin B1; Alanine Transaminase; Animals; Arylsulfotransfer | 1991 |
Influence of liver damage on antipyrine metabolite formation in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antipyrine; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1991 |
Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clonidine; | 1991 |
Reestablishment of the heterogeneous distribution of hepatic glutamine synthetase during regeneration after CCl4-intoxication.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutamate-Ammonia Ligase; Imm | 1990 |
Enhancement of carbon tetrachloride-induced liver injury by a single dose of ethanol: proton magnetic resonance imaging (MRI) studies in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclic N-Oxides; Drug Synergi | 1991 |
The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azocines; Carbon Tetrachloride; Chemical | 1991 |
67Ga in transferrin-unbound form is taken up by inflamed liver of mouse treated with CCl4.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gallium Radioisotopes; Liver; | 1990 |
Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.
Topics: Animals; Aspartic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutamates; Li | 1990 |
Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cloning, Molecular; DNA; Endo | 1990 |
Hypoxia and CCl4-induced liver injury, but not acidosis, impair metabolism of cysteinyl leukotrienes in perfused rat liver.
Topics: Acidosis; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hypoxia; In V | 1990 |
Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Ind | 1990 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li | 1990 |
[Effects of indomethacin on 45Ca uptake and membrane fluidity of mitochondria and microsomes from rat liver].
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Indomethacin; Male; | 1990 |
Inhibition of carbon tetrachloride-induced lipid peroxidation by novel antioxidants in rat hepatic microsomes: dissociation from hepatoprotective effects in vivo.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Carbon Tetrachloride; Cell Surviv | 1990 |
Blood coagulation variations induced by carbon tetrachloride inhalation in Wistar rats.
Topics: Analysis of Variance; Animals; Blood Coagulation; Carbon Tetrachloride; Chemical and Drug Induced Li | 1990 |
Protection by pantethine, pantothenic acid and cystamine against carbon tetrachloride-induced hepatotoxicity in the rat.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1990 |
Availability of exchange blood transfusion and plasma exchange in treatment of acute liver failure.
Topics: Acute Disease; Animals; Blood Transfusion; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1990 |
Effect of alpha-blockade on liver regeneration after carbon tetrachloride intoxication in the rat.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1990 |
Evidence of clonal proliferation of hepatocytes after carbon-tetrachloride-induced hepatic injury in PGK-1 mosaic mice.
Topics: Aging; Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Clone C | 1990 |
Serum lipid and lipoprotein changes in ponies with experimentally induced liver disease.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholesterol, HDL; Cholesterol | 1990 |
[Use of hepatocytes cultured in microcarriers for correction of acute hepatic insufficiency].
Topics: Acute Disease; Albumins; Animals; Bilirubin; Carbon Tetrachloride; Cells, Cultured; Chemical and Dru | 1990 |
Lipid quantitation in formalin-fixed liver sections.
Topics: Animals; Azo Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fixatives; For | 1988 |
[Effect of carbon tetrachloride and chloroform on hematologic parameters in rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Erythrocyte Count | 1989 |
Protection from chlordecone (Kepone)-potentiated CCl4 hepatotoxicity in rats by fructose 1,6-diphosphate.
Topics: Acetyltransferases; Adenosine Triphosphate; Adenosylmethionine Decarboxylase; Alanine Transaminase; | 1989 |
[Effect of (+) cyanidanol-3 on experimental liver cirrhosis induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Female; Free Radica | 1989 |
[Protective effects of the pollen of Codonopsis pilosula (Franch.) Nannf. on liver lesions at the ultrastructural level].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fibrosis; Liver; Male | 1989 |
Further studies on the mechanism of the late protective effects of phenylmethylsulfonyl fluoride on carbon tetrachloride-induced liver necrosis.
Topics: Administration, Oral; Animals; Body Temperature; Calcium; Carbon Radioisotopes; Carbon Tetrachloride | 1989 |
[Pharmacological effects of reiousan on experimental hepatic injuries and hepatic functions].
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dru | 1989 |
[Activity of lysosomal enzymes in drug-induced lesions of the liver].
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cathepsins; Chemical and Drug Induced Liver Injury; | 1989 |
Role of peptide-leukotrienes in liver injury in mice.
Topics: Acetophenones; Animals; Autacoids; Benzoquinones; Carbon Tetrachloride; Chemical and Drug Induced Li | 1989 |
In vivo studies on halogen compound interactions. II. Effects of carbon tetrachloride plus 1,2-dibromoethane on relative liver weight and hepatic steatosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethylene Dibromide; Fatty Aci | 1989 |
Late preventive effects against carbon tetrachloride-induced liver necrosis of the calcium chelating agent Calcion.
Topics: Animals; Body Temperature; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chelating | 1989 |
Effects of valine on 15N incorporation into serum and tissue protein and non-protein fractions following 15N-L-leucine administration to normal and liver-injured rats.
Topics: Amino Acids; Animals; Brain; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; L | 1989 |
Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Probes; Galactosamine; In | 1989 |
Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury.
Topics: Acute Disease; Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 1989 |
Relationship between hepatic glutathione content and carbon tetrachloride-induced hepatotoxicity in vivo.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fasting | 1989 |
Effect of iron overload on spontaneous and xenobiotic-induced lipid peroxidation in vivo.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol | 1989 |
Variations in serum sorbitol dehydrogenase, aspartate transaminase, and isoenzyme 5 of lactate dehydrogenase activities in horses given carbon tetrachloride.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1989 |
Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure of rats.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Dimethylnitros | 1989 |
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Live | 1989 |
Intrasplenic hepatocyte transplantation in rats with experimental liver injury: morphological and morphometric studies.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Dise | 1989 |
The role of thromboxane A2 [TxA2] in liver injury in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alanine Transaminase; Animals; A | 1989 |
[Protective action of kopsinine against experimental liver injuries in mice].
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Indole Alkaloids; | 1989 |
Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis, Viral, Animal; Her | 1987 |
Laboratory assessment of hepatic injury in the woodchuck (Marmota monax).
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Proteins; Ca | 1985 |
1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induce | 1985 |
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Che | 1985 |
Comparative study on the sensitivity of several serum enzymes in detecting hepatic damage in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon | 1985 |
Effect of rioprostil and colchicine on CCl4-acute liver damage in rats. Relationship with plasma membrane lipids.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Carbon Tetrachloride; Cell Membrane; | 1987 |
Suppression of humoral and cell-mediated immune responses by carbon tetrachloride.
Topics: Animals; Antibody Formation; Blood Chemical Analysis; Body Weight; Carbon Tetrachloride; Chemical an | 1989 |
[Studies on jiangmeiling chongji].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Medicin | 1987 |
[Preliminary studies on effect of fruit juice of Actinidia chinensis Planch on experimental liver lesions in mice].
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; | 1987 |
Suppression of delayed-type hypersensitivity mediated by macrophage-like cells in mice with experimental liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver I | 1985 |
Mechanism of chemical-induced toxicity. II. Role of extracellular calcium.
Topics: Animals; Calcimycin; Calcium; Carbon Tetrachloride; Carmustine; Cell Separation; Cell Survival; Chem | 1985 |
Late preventive effects of trifluoperazine on carbon tetrachloride-induced hepatic necrosis.
Topics: Animals; Body Temperature; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liv | 1986 |
Ultrastructural observation and glucose-6-phosphatase determination on the repair of rat experimental hepatic lesions by qing kai ling No. 1.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphatase; Liver; | 1987 |
Tetrachloromethane metabolism in vivo under normoxia and hypoxia. Biochemical and histopathological effects relative to alkane exhalation.
Topics: Alkanes; Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Ethan | 1987 |
The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1987 |
[The effect of the infusion of Haploppapus baylahuen in dogs with liver damage induced by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Liver Dis | 1988 |
Effects of epidermal growth factor, glucagon and insulin on the hepatocytes after experimental liver cell necrosis. In vivo studies with monoclonal anti-bromo-deoxyuridine staining.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Epidermal Growth Factor; | 1988 |
Protection against carbon tetrachloride hepatotoxicity by 5,10-dihydroindeno[1,2-b]indole, a potent inhibitor of lipid peroxidation.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical and Drug Induced | 1988 |
Blood clearance of 99mTc-phytate for evaluation of hepatic dysfunction in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Male; | 1988 |
Blood clearance of 99mTc-phytate for evaluation of hepatic dysfunction in dogs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1988 |
[Protective effect of Polyporus umbellatus polysaccharide on toxic hepatitis in mice].
Topics: Animals; Basidiomycota; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Galactosamine; | 1988 |
[Morphologic study of CCl4-induced liver necrosis in rats and its treatment with a "hepatitis No. III" decoction].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 1988 |
[Kupffer cell-derived growth factor in fibroblasts in acute liver injury induced by carbon tetrachloride].
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibroblast Gro | 1988 |
Decreased diuretic response to furosemide in rats with acute hepatic failure.
Topics: Adrenalectomy; Aldosterone; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; D | 1988 |
[Protective effect of dahuang zhechong pills on experimental hepatic injury].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female | 1988 |
[Evaluation of serum cathepsin B-like activity in liver diseases].
Topics: Animals; Carbon Tetrachloride; Cathepsin B; Chemical and Drug Induced Liver Injury; Galactosamine; H | 1988 |
[Acute toxicity of local anesthetic in rats bearing carbon tetrachloride-induced hepatic lesion].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry | 1988 |
Effects of ventromedial and lateral hypothalamic stimulation on chemically-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Denerva | 1988 |
Assessment of the minimal effective dose of acetone for potentiation of the hepatotoxicity induced by trichloroethylene-carbon tetrachloride mixtures.
Topics: Acetone; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug In | 1988 |
Exchange blood transfusion for acute hepatic failure: its limited availability depending on the type of injury in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Blood Coagulation; Carbon Tetrachloride; Chemical and | 1988 |
Effect of branched-chain amino acid on 15N incorporation into liver and skeletal muscle proteins following [15N]-ammonium chloride administration to carbon tetrachloride-intoxicated rats.
Topics: Amino Acids, Branched-Chain; Ammonium Chloride; Animals; Carbon Tetrachloride; Chemical and Drug Ind | 1988 |
Lipid peroxidation and cell viability in isolated hepatocytes in a redesigned oxystat system: evaluation of the hypothesis that lipid peroxidation, preferentially induced at low oxygen partial pressures, is decisive for CCl4 liver cell injury.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; In Vitro Techn | 1988 |
Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III.
Topics: Animals; Antithrombin III; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnit | 1988 |
Ultrastructural studies on the effect of "gan fu kang" in preventing experimental liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 1988 |
Hepatic protection from chemical injury by isoflurane.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1988 |
[Hepatic lesions induced by drugs. Report of 26 cases].
Topics: Adult; Aged; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 1987 |
Effects of methyl (+) (3S)-1,2,3,4-tetrahydro-3-hydroxymethyl-beta-carboline-2- carbodithioate(THC), a new hepatoprotective agent, on protein synthesis and chronic liver injury induced by carbon tetrachroride in rats.
Topics: Animals; Body Weight; Carbolines; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Live | 1987 |
The influence of single or repeated phlebotomy on the physiological condition of normal and diseased rats.
Topics: Anemia; Animals; Blood Cell Count; Blood Pressure; Bloodletting; Carbon Tetrachloride; Chemical and | 1987 |
Protein synthesis in Ito cells (fat-storing cells) of cultured liver tissues from CCL4-treated mice. A light and electron microscopic autoradiographic study.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Culture Tech | 1987 |
In vivo protection by protein A of hepatic microsomal mixed function oxidase system of CCl4-administered rats.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydr | 1987 |
[Effects of one-day food restriction on the metabolism and toxicity of organic solvents in rats].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diet; Hydrocarbons; Inactivat | 1986 |
Potentiation of carbon tetrachloride hepatotoxicity by hypoxia.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1986 |
Changes of haemostaseological variables in carbon tetrachloride poisoning in rats.
Topics: Animals; Antithrombin III; Blood Coagulation Tests; Carbon Tetrachloride; Carbon Tetrachloride Poiso | 1985 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug I | 1986 |
Hyperbaric oxygen protection against carbon tetrachloride hepatotoxicity in the rat. Association with altered metabolism.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hyperbaric Oxygenation; Liver | 1986 |
Liver damage does not increase the sensitivity of mice to cyanide given acutely.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1985 |
[Substance-induced liver injury as a model for evaluating hepatoprotective drugs].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug | 1985 |
[Therapeutic effect of TRQ on chronic liver injury model in rats induced by CCl4].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachloride; Chemi | 1985 |
Propionate loading test for liver function during experimental liver necrosis in sheep.
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Glucon | 1985 |
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochro | 1985 |
An investigation into the association between liver damage and metastatic uveal melanoma.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cricetinae; Liver Diseases; L | 1985 |
Comparison of the requirements for hepatic injury with halothane and enflurane in rats.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical | 1985 |
Ethanol potentiation of carbon tetrachloride hepatotoxicity: possible role for the in vivo inhibition of aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytos | 1985 |
[Excretion of phenoltetrachlorophthalein in rats with experimental liver lesions].
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver Diseases; | 1985 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1985 |
Effect of phorone-induced glutathione depletion on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1985 |
The application of some liver function tests to sheep dosed with carbon tetrachloride and hexachlorphene.
Topics: Alkaline Phosphatase; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Car | 1971 |
The comparison of arginine content in serum proteins in rats with Guerin tumour and in experimental induced intoxication with CCl 4 and HgCl 2 .
Topics: Alkaline Phosphatase; Alpha-Globulins; Animals; Arginine; Beta-Globulins; Blood Proteins; Carbon Tet | 1971 |
Liver parenchymal cell injury. VII. Membrane denaturation following carbon tetrachloride.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; Chemi | 1971 |
Influence of cold environment on hepatic changes produced by repeated doses of carbon tetrachloride.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride | 1972 |
Distribution of clioquinol in rats with hepatic dysfunction.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clioquinol; Fatty Liver; Iodi | 1973 |
Prevention and treatment of carbon tetrachloride hepatotoxicity by cysteine: studies about its mechanism.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1974 |
Gamma-glutamyl transpeptidase: a clinical and experimental study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon | 1972 |
[Pharmacological study on thiamine triphosphate (TTP)].
Topics: Adenosine Triphosphatases; Animals; Anura; Blood Pressure; Carbon Tetrachloride; Cats; Cerebral Cort | 1967 |
Histochemical study of the effects of some anthelmintics in experimental fascioliasis in the rat.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Anilides; Animals; Anthelmintics; Carbon Tetrachlor | 1968 |
[Effect of xanthinol-nicotinate on detoxification processes in liver. Experimental studies on the model of hexobarbital-narcosis in rat].
Topics: Anesthesia, General; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dru | 1969 |
[Effect of carbon tetrachloride on the extent of incorporation of methionine-35S into proteins of various organs in guinea pigs].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1970 |
[Changes in the bile secretion and bile ductules in the course of development of experimental hepatitis and liver cirrhosis].
Topics: Acute Disease; Adenosine Triphosphatases; Animals; Bile; Bile Ducts; Carbon Tetrachloride; Chemical | 1971 |
The role of perisinusoidal cells in experimental hepatic fibrogenesis.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; En | 1972 |
Liver response tests. I. Exploratory studies on glucose 6-phosphatase and other liver enzymes.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cathepsins; Chemical and Drug Induced Liver Injury; | 1965 |
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1970 |
Differences in the carbon tetrachloride-induced damage to components of the smooth and rough endoplasmic reticulum from rat liver.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1973 |
Angiotensins lung converting enzyme.
Topics: Angiotensin II; Animals; Blood Pressure; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1973 |
Sulfaguanidine protection of mouse liver from carbon tetrachloride-induced necrosis.
Topics: Aniline Compounds; Animals; Autoradiography; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1973 |
Quantitative hepatic cytology. Experimental study.
Topics: Analysis of Variance; Animals; Biopsy; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Co | 1972 |
Hepatocellular tolerance to carbon tetrachloride induced injury in the rat: a study of its nature and possible mode of evolution.
Topics: Animals; Biopsy; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1974 |
Preventive effect of riboflavin 2',3',4',5'-tetrabutyrate on inactivation of rat liver microsomal enzymes induced by carbon tetrachloride.
Topics: Animals; Antioxidants; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and | 1974 |
The protective effect of nicotinamide on carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antidotes; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1967 |
Effect of carbon tetrachloride on induction of liver enzymes by acute stress or corticosterone.
Topics: Adrenalectomy; Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical a | 1969 |
Biochemical basis for the in vitro pro-oxidant action of carbon tetrachloride.
Topics: Aldehydes; Animals; Antimetabolites; Benzene; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1969 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; | 1971 |
[Effect of experimental liver damage on the reduction of testosterone and 4-androstene-3,17-dione].
Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1972 |
The effect of carbon tetrachloride on radiocerium metabolism in rats.
Topics: Animals; Carbon Tetrachloride; Cerium Isotopes; Chemical and Drug Induced Liver Injury; Female; Inje | 1974 |
The effects of phenobarbital and carbon tetrachloride on the rate of decline of body burdens of hexachlorobenzene in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Body Burden; Carbon Tetrachloride; Chemical a | 1974 |
Effect of splenectomy on acute hepatic injury by carbon tetrachloride in albino rats.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; | 1974 |
Time course of protection by N'N--diphenyl-p-phenylendiamine (DPPD) against carbon tetrachloride hepatotoxicy.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1974 |
Histopathological changes in rat incisors in experimental carbon tetrachloride intoxication.
Topics: Alkaline Phosphatase; Amelogenesis; Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Indu | 1973 |
[Effect of a second CCl 4 -intoxication on CCl 4 -damaged mouse liver].
Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Nucleus; Chemic | 1972 |
Pyrazole blockade of carbon tetrachloride activation and liver necrosis.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1972 |
[Effect of 6-ethoxy 2,2,4-trimethyl-1,2-dihydroquinoline (ethoxyquin) on carbon tetrachloride metabolism in the rat].
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachlor | 1973 |
[Comparative angiographic and scintigraphic studies in experimental parenchymatous and obstructive jaundice].
Topics: Alanine Transaminase; Alkaline Phosphatase; Angiography; Animals; Bilirubin; Blood Coagulation Tests | 1973 |
Effect of experimental hepatic injury on the clearance of phenobarbital and paraldehyde.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Carbon | 1973 |
Potentiation of CCl4-induced hepatotoxicity in the dog by chronic exposure to phenobarbital.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1973 |
Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen.
Topics: Animals; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Tests; Body Weight; | 1973 |
[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat. I].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1973 |
[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat. II].
Topics: Acrylates; Alanine Transaminase; Alkaline Phosphatase; Amides; Animals; Aspartate Aminotransferases; | 1973 |
Decreased toxicity of dimethylnitrosamine in rats after treatment with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylamines; DNA; Kidney; | 1973 |
Studies on hepatic uptake of antigen. II. The effect of hepatotoxins on the immune response.
Topics: Animals; Antibody Formation; Antigens; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1973 |
Phenobarbital and organic solvent toxicity.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1973 |
The metabolism of the isolated perfused canine liver.
Topics: Animals; Carbohydrate Metabolism; Carbon Dioxide; Carbon Tetrachloride; Chemical and Drug Induced Li | 1973 |
Studies on aminopeptidases in rat liver and plasma.
Topics: Aminopeptidases; Animals; Bromelains; Carbon Tetrachloride; Catheterization; Chemical and Drug Induc | 1973 |
[Morphological results of combined action of carbon tetrachloride and heightened room temperature in a short-time animal experiment].
Topics: Adrenal Glands; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 1973 |
Liver regeneration and uraemia.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Lectins; Liver; Liver Re | 1973 |
[An autoradiographic study of DNA and RNA synthesis in the liver cells of mice with chronic carbon tetrachloride poisoning].
Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1973 |
Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism--further studies on their mechanism of action.
Topics: Animals; Antimetabolites; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |
Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).
Topics: 1-Propanol; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1974 |
Dimethylsulfoxide increases the lethality of CCl4 in rats but decreases its hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1974 |
Susceptibility of rabbits to pyrogenic and lethal effects of endotoxin after acute liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endotoxins; Escherichia coli; | 1968 |
In-vivo nuclear localisation of human antinuclear antibodies in mice with carbon tetrachloride- and thioacetamide-induced hepatic necrosis.
Topics: Amides; Animals; Antibodies, Antinuclear; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1970 |
[Phosphofructaldose activity in acute liver damage of the horse].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fructose-Bisphosphate Aldolas | 1967 |
Age as a modifying factor of chronic hepatic injury in albino rats.
Topics: Age Factors; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dietary Fats; p- | 1967 |
The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.
Topics: Acetates; Amides; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1969 |
Hepatotoxicity of carbon tetrachloride in sheep. 2. Influence of ingestion of Heliotropium europaeum.
Topics: Animal Nutritional Physiological Phenomena; Animals; Aspartate Aminotransferases; Biopsy; Carbon Tet | 1972 |
Plasticizers in P.V.C. and the occurrence of hepatitis in a haemodialysis unit. A preliminary communication.
Topics: Adult; Antigen-Antibody Reactions; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1971 |
Carbon tetrachloride hepatotoxicity in female rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Lipid Metabolism; Liv | 1971 |
[Transitory cell antigens of rat liver. I. The secretion and synthesis of fetospecific serum proteins during hepatic development and regeneration].
Topics: Aging; Amniotic Fluid; Animals; Animals, Newborn; Blood Proteins; Cadmium; Carbon Isotopes; Carbon T | 1971 |
Selective potentiation of carbon tetrachloride hepatotoxicity by ethanol.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1971 |
3-Methylcholanthrene blocks hepatic necrosis induced by administration of bromobenzene or carbon tetrachloride.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Indu | 1971 |
Correlation between serum enzymes, isozyme patterns and histologically detectable organ damage.
Topics: Acetamides; Amino Alcohols; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1971 |
Lysosomal injury and hepatic necrosis. Effects of triton WR-1339 on liver cells in the rat.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Inju | 1971 |
[Comparative studies on the induction of chronic hepatitis in the rat].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Diabetes Mel | 1971 |
Resolution of microheterogeneous forms of glucose-6-phosphate dehydrogenase by electrophoresis on cellulose acetate.
Topics: Acetates; Animals; Carbon Tetrachloride; Cellulose; Chemical and Drug Induced Liver Injury; Electrop | 1971 |
Effect of carbon tetrachloride induced progressive liver damage on the metabolism of hexobarbital and bilirubin in vivo.
Topics: Animals; Bilirubin; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hexob | 1971 |
[Patterns of rat liver damage following intrasplenic injection of differentially dispersed carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1971 |
[Reduction of testosterone and androst-4en-3,17-dione in experimentally damaged rat liver].
Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1971 |
The essential role of the liver in detoxification of endotoxin.
Topics: Animals; Biotransformation; Blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chi | 1966 |
Effects of xylitol on carbohydrate metabolism in rat liver treated with carbon tetrachloride or alloxan.
Topics: Alcohols; Animals; Carbohydrate Metabolism; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug | 1969 |
Vitamin E, nicotinic acid, vitamin C and total belladonna alkaloids as liver cell regenerators.
Topics: Animals; Ascorbic Acid; Atropa belladonna; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1969 |
Effects of environmental agents at the level of enzyme-forming systems.
Topics: Aflatoxins; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Environment; Envi | 1969 |
Vitamin E and hepatotoxic agents. 3. Vitamin E, synthetic antioxidants and carbon tetrachloride toxicity in the rat.
Topics: Aniline Compounds; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1970 |
Effect of liver injury and of induced inflammation on the serum glycoprotein level.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Croton Oil; Glycoproteins; He | 1970 |
[Quinine oxidase in an experimental damage of rat liver].
Topics: Alcohol Oxidoreductases; Alcohols; Amides; Animals; Carbon Tetrachloride; Chemical and Drug Induced | 1970 |
[The influence of norepinephrine on the hepatotoxicity of carbon tetrachloride and allyl alcohol].
Topics: Alanine Transaminase; Alcohols; Alkenes; Allyl Compounds; Animals; Aspartate Aminotransferases; Carb | 1970 |
Inactivation of gastrin-like synthetic peptide by the liver and serum, and its clinical significance.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Gastric Juice; Gastrins; Live | 1971 |
Toxicity of carbon tetrachloride and other fasciocidal drugs in sheep and chickens.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Anthelmintics; Aspartate Aminotransferases; | 1971 |
Effect of pretreatment with barbiturates on carbon tetrachloride-induced hepato-toxicity in rats.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induc | 1971 |
Potentiation of carbon tetrachloride hepatotoxicity by ethanol and cold.
Topics: Alanine Transaminase; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 1971 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
[Studies on the mechanism of enzyme induction. XVI. Relationship between enzyme induction and repair in the case of ascorbic acid synthesis in rat liver following carbon tetrachloride damage].
Topics: Animals; Ascorbic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Inducti | 1971 |
[Histochemical and biochemical behavior of beta-glucuronidase in experimental liver parenchymal lesions].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glucuronidase; Histocytochemi | 1967 |
[Malformation and liver damage. On the necessary 2nd noxa in experimental thalidomide embryopathies].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Chemical and Dr | 1967 |
[The inhibition of carbon tetrachloride induced liver fibrosis in rats with aminoacetonitrile].
Topics: Acetates; Amines; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; C | 1967 |
Protection by reserpine of carbon tetrachloride-induced hepatic necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Histocytoche | 1968 |
Contribution to the study of carbon tetrachloride toxicity.
Topics: Alanine Transaminase; Animals; Blood Glucose; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1968 |
[Effect of the toxic damage to the liver by carbon tetrachloride on the content of collagen in granulation tissue of rats].
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Gr | 1968 |
A comparison of the chronic effects of irradiation upon the normal, damaged, and regenerating rat liver.
Topics: Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Iodine R | 1968 |
Sporidesmin poisoning in the sheep. I. Changes in bile secretion and the excretion of sporidesmin in bile.
Topics: Animals; Bile; Bile Ducts; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1968 |
[Effect of reticulo-endothelial system blockade and toxic lesion of liver cells on the dynamics of Coxsackie virus circulation in the blood].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coxsackievirus Infections; Li | 1968 |
Lipid metabolites of carbon tetrachloride.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1969 |
Portal hypertension in acute experimental veno-occlusive disease of the liver in rats.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure Determination; Carbon Tetrachloride; Chemical and Dr | 1969 |
Ornithine carbamyl transferase as a liver function test comparative studies in the dog, swine, and man.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arteries; Aspartate Aminotransferases; Biliary | 1969 |
The effect of trypan blue on the hepatotoxicity of carbon tetrachloride in the rat.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1969 |
Early incorporation of carbon-labeled carbon tetrachloride into rat liver particulate lipids and proteins.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1969 |
Catecholamine potentiation of carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Live | 1969 |
Clinical studies on serum ionic calcium in domestic animals. VI. Effect of intravenous injection of calcium ion solution in healthy animals and those with liver damage.
Topics: Animals; Bone Marrow; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dogs; I | 1965 |
Clinical studies on serum ionic calcium in domestic animals. VII. Effect of peroral administration of calcium on rabbits with liver damaged experimentally.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ions; Liver Diseases | 1965 |
Metabolism of radioactive zinc in the liver damaged with carbon tetrachloride. II. Autoradiographic studies.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1966 |
Phenothiazine inhibition of carbon tetrachloride cytotoxicity in vitro.
Topics: Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorprom | 1966 |
[Effect of manganese compounds on the fat content in the liver of animals poisoned by carbon tetrachloride].
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Ind | 1966 |