carbon monoxide and Respiratory Insufficiency studies

Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.

Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Carbon monoxide poisoning may damage the brain and adrenal glands, but it is unclear whether it is associated with adrenal insufficiency."	8.12	Association between carbon monoxide poisoning and adrenal insufficiency: a nationwide cohort study. ( Chen, YC; Guo, HR; Ho, CH; Hsu, CC; Huang, CC; Lin, HJ; Su, SB; Wang, JJ, 2022)
" Severe carbon monoxide poisoning with fatal levels of HbCO (greater than 50 percent) was found at the end of smoke inhalation."	7.68	The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. ( Li, A; Wang, CZ; Yang, ZC, 1990)
" Computed tomography-measured sarcopenia, and pulmonary function (forced expiratory volume in first second/forced vital capacity/diffusion capacity for carbon monoxide) were compared pretherapy and posttherapy."	5.51	CROSS Versus FLOT Regimens in Esophageal and Esophagogastric Junction Adenocarcinoma: A Propensity-Matched Comparison. ( Cools-Lartigue, J; Cunningham, M; Davern, M; Donlon, NE; Donohoe, CL; Ferri, L; Kamilli, A; King, S; Lowery, M; Moran, B; Mueller, C; Ravi, N; Reynolds, JV; Sheppard, A, 2022)
"Carbon monoxide poisoning may damage the brain and adrenal glands, but it is unclear whether it is associated with adrenal insufficiency."	4.12	Association between carbon monoxide poisoning and adrenal insufficiency: a nationwide cohort study. ( Chen, YC; Guo, HR; Ho, CH; Hsu, CC; Huang, CC; Lin, HJ; Su, SB; Wang, JJ, 2022)
" In multivariate analysis, chronic graft-versus-host disease (relative risk, 16) and pretransplantation diffusion capacity for carbon monoxide or forced expiratory volume in the first second <80% predicted were independently associated with a late decrease in PF from baseline (relative risk, 7)."	3.73	Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. ( Barrett, AJ; Childs, R; Karimpour, S; Mielke, S; Montero, A; Rezvani, K; Savani, BN; Shenoy, A; Singh, A; Srinivasan, R, 2006)
" Severe carbon monoxide poisoning with fatal levels of HbCO (greater than 50 percent) was found at the end of smoke inhalation."	3.68	The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. ( Li, A; Wang, CZ; Yang, ZC, 1990)
"To define the relationship between hypoxemia and VCO/VCO2 deficit."	1.31	[Pulmonary circulatory amputation in chronic respiratory insufficiency. Simple, anodyne, and fast evaluation]. ( Bréant, J; Fleury, MF, 2001)

Research

Studies (33)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Disease Progression at Baseline With Decline in FEV1 Greater Than 10%

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (48.48)	18.7374
1990's	5 (15.15)	18.2507
2000's	9 (27.27)	29.6817
2010's	1 (3.03)	24.3611
2020's	2 (6.06)	2.80

Authors	Studies
Donlon, NE	1
Moran, B	1
Kamilli, A	1
Davern, M	1
Sheppard, A	1
King, S	1
Donohoe, CL	1
Lowery, M	1
Cunningham, M	1
Ravi, N	1
Mueller, C	1
Cools-Lartigue, J	1
Ferri, L	1
Reynolds, JV	1
Huang, CC	1
Ho, CH	1
Chen, YC	1
Hsu, CC	1
Lin, HJ	1
Wang, JJ	1
Su, SB	1
Guo, HR	1
Weinreich, UM	1
Thomsen, LP	1
Brock, C	1
Karbing, DS	1
Rees, SE	1
Semeniuk, GB	1
Chien, JW	1
Sullivan, KM	1
Matejovic, M	1
Rokyta, R	1
Radermacher, P	1
Krouzecky, A	1
Sramek, V	1
Novak, I	1
KREUKNIET, J	1
VISSER, BF	1
DECHOUX, J	1
PIVOTEAU, C	1
Gu, Z	1
Januszkiewicz, AJ	1
Mayorga, MA	1
Coleman, GD	1
Morrissette, CR	1
Baser, S	1
Shannon, VR	1
Eapen, GA	1
Jimenez, CA	1
Onn, A	1
Keus, L	1
Lin, E	1
Morice, RC	1
Takeda, S	1
Funakoshi, Y	1
Kadota, Y	1
Koma, M	1
Maeda, H	1
Kawamura, S	1
Matsubara, Y	1
Savani, BN	1
Montero, A	1
Srinivasan, R	1
Singh, A	1
Shenoy, A	1
Mielke, S	1
Rezvani, K	1
Karimpour, S	1
Childs, R	1
Barrett, AJ	1
Irrazabal, CL	1
Capdevila, AA	1
Revich, L	1
Del Bosco, CG	1
Luna, CM	1
Vujacich, P	1
Villa, R	1
Jorge, MA	1
Lewis, BM	1
Bork, B	1
Randowa, D	1
Fisher, CJ	1
Johanson, WG	1
Holcomb, JR	1
Coalson, JJ	1
Bréant, J	3
Fleury, MF	3
Goudin, J	1
Bance, N	1
Cerfolio, RJ	1
Allen, MS	1
Trastek, VF	1
Deschamps, C	1
Scanlon, PD	1
Pairolero, PC	1
Melendez, JA	1
Barrera, R	1
Patsch, J	1
Guenard, H	1
Denjean, A	1
Chaussain, M	1
de Lattre, J	1
Gamain, B	1
Vanuxem, D	1
Guillot, C	1
Fornaris, E	1
Weiller, PJ	1
Grimaud, C	1
Subramanian, VA	1
Berger, RL	1
Wang, CZ	1
Li, A	1
Yang, ZC	1
Arturson, G	1
Petro, W	1
Harzendorf, E	1
Wuthe, H	1
Lachmann, B	1
Vogel, J	1
Vandenbergh, E	1
Clement, J	1
Van de Woestijne, KP	1
Roullier, A	1
Homasson, JP	1
Lavandier, M	1
Moline, J	1
Baudouin, J	1
Lacoste, J	1
Vorob'eva, ZV	1
Khabakov, AI	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
High Intensity Respiratory Muscle Training as a Pre-habilitation in Lung Surgery[NCT04826575]		150 participants (Anticipated)	Interventional	2021-03-25	Recruiting
Phase II Trial of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for Treatment of Bronchiolitis Obliterans Syndrome[NCT01287078]	Phase 2	25 participants (Actual)	Interventional	2011-01-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Participants with progressive disease at baseline with decline in FEV1 greater than 10% (NCT01287078)
Timeframe: 18 weeks

Disease Progression at Baseline With Stablization of FEV1

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	2
Inhaled Cyclosporine in Lung Transplant Recipients	0

Participants with progressive disease at baseline with stablization of FEV1 (NCT01287078)
Timeframe: 18 weeks

Disease Stability at Baseline With Stablization in FEV1 and Greater Than 25% Decline in Systemic Immunosuppression

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	2
Inhaled Cyclosporine in Lung Transplant Recipients	0

Participants with stable disease at baseline with stablization in FEV1 and greater than 25% decline in systemic immunosuppression (NCT01287078)
Timeframe: 18 weeks

Overall Non-response to Treatment

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	3
Inhaled Cyclosporine in Lung Transplant Recipients	0

Participants who did not respond to treatment with cyclosporine inhalation solution (CIS) (NCT01287078)
Timeframe: 18 weeks

Overall Response to Treatment Based on Positive Response to Cyclosporine Inhalation Solution (CIS)

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	7
Inhaled Cyclosporine in Lung Transplant Recipients	2

Participants who responded to treatment with cyclosporine inhalation solution (CIS) (NCT01287078)
Timeframe: 18 weeks

Stable Disease at Baseline With Stablization of FEV1 and no Change or Increase in Systemic Immunosuppresion

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	9
Inhaled Cyclosporine in Lung Transplant Recipients	0

Participants with stable disease at baseline with stablization of FEV1 and no change or increase in systemic immunosuppresion (NCT01287078)
Timeframe: 18 weeks

Stable or Progressive Disease at Baseline With Greater Than 20% of Decline in FEV1

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	4
Inhaled Cyclosporine in Lung Transplant Recipients	2

Participants with stable or progressive disease at baseline with greater than 20% of decline in FEV1 (NCT01287078)
Timeframe: 18 weeks

Stable or Progressive Disease at Baseline With Improvement of FEV1

Intervention	Participants (Count of Participants)
Inhaled Cyclosporine in HSCT Recipients	1
Inhaled Cyclosporine in Lung Transplant Recipients	0

Participants with stable or progressive disease at baseline with improvement of FEV1 (NCT01287078)
Timeframe: 18 weeks

Article	Year
CROSS Versus FLOT Regimens in Esophageal and Esophagogastric Junction Adenocarcinoma: A Propensity-Matched Comparison. Annals of surgery, 2022, 11-01, Volume: 276, Issue:5 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Esophageal Neoplasm	2022
[Measurement of global diffusion capacity for CO, membrane diffusion capacity for CO and capillary blood volume in patients with bronchial emphysema after fominoben HCl. Short- and long-time trials (author's transl)]. Arzneimittel-Forschung, 1979, Volume: 29, Issue:2 Topics: Adult; Blood Volume; Capillaries; Carbon Monoxide; Cell Membrane; Chronic Disease; Clinical Trials a	1979

Article	Year
Association between carbon monoxide poisoning and adrenal insufficiency: a nationwide cohort study. Scientific reports, 2022, 09-28, Volume: 12, Issue:1 Topics: Adrenal Insufficiency; Carbon Monoxide; Carbon Monoxide Poisoning; Child; Child, Preschool; Cohort S	2022
Diffusion capacity of the lung for carbon monoxide - A potential marker of impaired gas exchange or of systemic deconditioning in chronic obstructive lung disease? Chronic respiratory disease, 2015, Volume: 12, Issue:4 Topics: Aged; Blood Gas Analysis; Blood Glucose; Carbon Dioxide; Carbon Monoxide; Cohort Studies; Female; Fo	2015
[Fire disaster and smoke inhalation]. Medicina, 2008, Volume: 68, Issue:6 Topics: Air Pollutants; Carbon Monoxide; Humans; Inhalation Exposure; Respiratory Insufficiency; Smoke; Smok	2008
Carbon monoxide diffusion capacity: how low can you go for hematopoietic cell transplantation eligibility? Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009, Volume: 15, Issue:4 Topics: Adult; Carbon Monoxide; Diffusion; Female; Guidelines as Topic; Hematologic Neoplasms; Hematopoietic	2009
Effect of prone position on hepato-splanchnic hemodynamics in acute lung injury. Intensive care medicine, 2002, Volume: 28, Issue:12 Topics: Acute Disease; Adult; Aged; Analysis of Variance; Carbon Monoxide; Coloring Agents; Critical Illness	2002
[THE DIFFUSION CAPACITY OF THE LUNGS FOR CARBON MONOXIDE DETERMINED WITH THE AID OF ARTERIAL AND ALVEOLAR CARBON DIOXIDE PRESSURE IN PATIENTS WITH VENTILATION DISORDERS]. Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere, 1963, Volume: 277 Topics: Asthma; Carbon Dioxide; Carbon Monoxide; Humans; Lung; Pulmonary Emphysema; Respiration Disorders; R	1963
[STUDY OF RESPIRATORY DISORDERS IN PNEUMOCONIOSIS PATIENTS BY MEASURING THE ALVEOLO-CAPILLARY DIFFUSION OF CARBON MONOXIDE]. Medicina thoracalis, 1964, Volume: 21 Topics: Asthma; Capillaries; Carbon Monoxide; Diagnosis, Differential; Humans; Pneumoconiosis; Pulmonary Alv	1964
Consequences of brief exposure to high concentrations of carbon monoxide in conscious rats. Inhalation toxicology, 2005, Dec-01, Volume: 17, Issue:13 Topics: Administration, Inhalation; Animals; Carbon Monoxide; Carbon Monoxide Poisoning; Dose-Response Relat	2005
Pulmonary dysfunction as a major cause of inoperability among patients with non-small-cell lung cancer. Clinical lung cancer, 2006, Volume: 7, Issue:5 Topics: Aged; Carbon Monoxide; Carcinoma, Non-Small-Cell Lung; Exercise Test; Female; Forced Expiratory Volu	2006
Fall in diffusing capacity associated with induction therapy for lung cancer: a predictor of postoperative complication? The Annals of thoracic surgery, 2006, Volume: 82, Issue:1 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbon Monoxide; Carcinoma, La	2006
Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:12 Topics: Adolescent; Adult; Carbon Monoxide; Child; Chronic Disease; Comorbidity; Disease Progression; Female	2006
Early and late complications among 15 victims exposed to indoor fire and smoke inhalation. Burns : journal of the International Society for Burn Injuries, 2008, Volume: 34, Issue:4 Topics: Adolescent; Adult; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Creatine Kinase; Critical Care; Fe	2008
An analog computer analysis of regional diffusing capacity in airflow obstruction. Journal of applied physiology, 1967, Volume: 22, Issue:6 Topics: Acetylene; Adult; Aged; Asthma; Carbon Monoxide; Computers, Analog; Female; Humans; Lung; Male; Midd	1967
[Disturbances in diffusion in chronic pulmonary diseases (Carbon monoxide method)]. Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1967, Volume: 35, Issue:5 Topics: Adolescent; Adult; Aged; Carbon Monoxide; Female; Humans; Lung Diseases; Male; Middle Aged; Pulmonar	1967
Physiology of respiration. Emergency medicine clinics of North America, 1983, Volume: 1, Issue:2 Topics: Adult; Airway Resistance; Carbon Monoxide; Female; Humans; Hypoxia; Lung Compliance; Lung Volume Mea	1983
Experimental diffuse alveolar damage in baboons. The American review of respiratory disease, 1982, Volume: 126, Issue:1 Topics: Acute Disease; Animals; Carbon Monoxide; Disease Models, Animal; Male; Oleic Acid; Oleic Acids; Oxyg	1982
[Gas exchange during spontaneous and controlled ventilation in obese subjects with chronic bronchitis. Value of normalized CO intake]. Revue de pneumologie clinique, 1993, Volume: 49, Issue:5 Topics: Adult; Aged; Blood Gas Analysis; Bronchitis; Carbon Monoxide; Chronic Disease; Female; Humans; Male;	1993
Lung resection in patients with compromised pulmonary function. The Annals of thoracic surgery, 1996, Volume: 62, Issue:2 Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Carbon Monoxide; Carcinoma; Contraindications; Female;	1996
Predictive respiratory complication quotient predicts pulmonary complications in thoracic surgical patients. The Annals of thoracic surgery, 1998, Volume: 66, Issue:1 Topics: Algorithms; Carbon Dioxide; Carbon Monoxide; Cause of Death; Critical Care; Databases as Topic; Fema	1998
[Pulmonary circulatory amputation in chronic respiratory insufficiency. Simple, anodyne, and fast evaluation]. Revue de pneumologie clinique, 2001, Volume: 57, Issue:6 Topics: Aged; Carbon Dioxide; Carbon Monoxide; Chronic Disease; Female; Humans; Hypoxia; Lung; Male; Middle	2001
[Arterio-alveolar difference in CO2 (AaDCO2) : measurement, interpretation, clinical value]. Le Poumon et le coeur, 1978, Volume: 34, Issue:2 Topics: Aged; Blood Gas Analysis; Carbon Dioxide; Carbon Monoxide; Humans; Methods; Models, Biological; Pulm	1978
Secondary polycythaemia in chronic respiratory insufficiency. Thorax, 1977, Volume: 32, Issue:3 Topics: Carbon Monoxide; Chronic Disease; Diphosphoglyceric Acids; Erythrocytes; Hemoglobins; Humans; Oxygen	1977
Carbon monoxide accumulation during extracoporeal membrane oxygenation for acute respiratory failure. The Annals of thoracic surgery, 1976, Volume: 22, Issue:2 Topics: Adult; Blood Gas Analysis; Carbon Monoxide; Extracorporeal Circulation; Humans; Hypoxia; Male; Oxyge	1976
[Alterations of pulmonary blood perfusion in chronic respiratory insufficiency. Evaluation by normalized carbon monoxide uptake measured at the patient's bedside after intensive care]. Revue de pneumologie clinique, 1990, Volume: 46, Issue:6 Topics: Adult; Aged; Blood Gas Analysis; Carbon Dioxide; Carbon Monoxide; Critical Care; Female; Humans; Mal	1990
The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. Chest, 1990, Volume: 97, Issue:3 Topics: Acute Disease; Animals; Bronchi; Carbon Monoxide; Carbon Monoxide Poisoning; Disease Models, Animal;	1990
Complete oxyhemoglobin dissociation curves in thermal trauma. Advances in experimental medicine and biology, 1972, Volume: 33, Issue:0 Topics: Adult; Age Factors; Binding Sites; Burns; Carbon Dioxide; Carbon Monoxide; Carboxyhemoglobin; Diphos	1972
[Pulmonary diffusion analysis using an own instrumental unit and a computer program for quick determination of total diffusion and its particular components]. Zeitschrift fur Erkrankungen der Atmungsorgane, 1974, Volume: 140, Issue:3 Topics: Apnea; Blood Volume; Capillaries; Carbon Dioxide; Carbon Monoxide; Computers; Diagnosis, Computer-As	1974
Course and prognosis of patients with advanced chronic obstructive pulmonary disease. Evaluation by means of functional indices. The American journal of medicine, 1973, Volume: 55, Issue:6 Topics: Adult; Aged; Blood Gas Analysis; Bronchitis; Carbon Dioxide; Carbon Monoxide; Electrocardiography; E	1973
[Determination of the membrane factor in alveolo-capillary exchanges. Clinical application]. Le Poumon et le coeur, 1973, Volume: 29, Issue:2 Topics: Capillaries; Capillary Permeability; Carbon Monoxide; Diffusion; Humans; Membranes; Methods; Models,	1973
[Functional respiratory investigations. Ductance of CO (carbon monoxide): global estimation of pulmonary exchanger, omitting blood tests]. La Presse medicale, 1971, Oct-02, Volume: 79, Issue:41 Topics: Adult; Blood Gas Analysis; Bronchitis; Carbon Monoxide; Chronic Disease; Humans; Infant, Newborn; Lu	1971
[Xenon 133 investigation of gas absorption in the lungs]. Meditsinskaia radiologiia, 1971, Volume: 16, Issue:4 Topics: Carbon Monoxide; Humans; Lung Diseases; Permeability; Radioisotopes; Respiratory Function Tests; Res	1971

carbon monoxide and Respiratory Insufficiency