carbon monoxide has been researched along with Melanoma in 4 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) induces DNA damage via a chloroethyl adduct at the O(6) position of guanine, which can be repaired by O(6)-alkylguanine DNA alkyltransferase (AGT) expressed in melanoma." | 9.11 | Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. ( Dolan, E; Gajewski, TF; Gerson, SL; Lin, S; Liu, L; Sosman, J; Vokes, EE, 2005) |
| "1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) induces DNA damage via a chloroethyl adduct at the O(6) position of guanine, which can be repaired by O(6)-alkylguanine DNA alkyltransferase (AGT) expressed in melanoma." | 5.11 | Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. ( Dolan, E; Gajewski, TF; Gerson, SL; Lin, S; Liu, L; Sosman, J; Vokes, EE, 2005) |
| " The data support the hypothesis that LAK cells have an additional toxic effect on the lung." | 1.29 | Pulmonary toxicity of recombinant interleukin-2 plus lymphokine-activated killer cell therapy. ( Galimberti, M; Manzi, R; Rizzi, M; Villani, F, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Venkatesh, Y | 1 |
| Vangala, V | 1 |
| Mengji, R | 1 |
| Chaudhuri, A | 1 |
| Bhattacharya, S | 1 |
| Datta, PK | 1 |
| Banerjee, R | 1 |
| Jana, A | 1 |
| Singh, NDP | 1 |
| Zhai, T | 1 |
| Zhong, W | 1 |
| Gao, Y | 1 |
| Zhou, H | 1 |
| Zhou, Z | 1 |
| Liu, X | 1 |
| Yang, S | 1 |
| Yang, H | 1 |
| Gajewski, TF | 1 |
| Sosman, J | 1 |
| Gerson, SL | 1 |
| Liu, L | 1 |
| Dolan, E | 1 |
| Lin, S | 1 |
| Vokes, EE | 1 |
| Villani, F | 1 |
| Galimberti, M | 1 |
| Rizzi, M | 1 |
| Manzi, R | 1 |
1 trial available for carbon monoxide and Melanoma
| Article | Year |
|---|---|
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineopla | 2005 |
3 other studies available for carbon monoxide and Melanoma
| Article | Year |
|---|---|
One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Carbon Monoxide; Cell Line, Tumor; Dioxoles; | 2022 |
Tumor Microenvironment-Activated Nanoparticles Loaded with an Iron-Carbonyl Complex for Chemodynamic Immunotherapy of Lung Metastasis of Melanoma
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Monoxide; Cell Line, Tumor; Cell Proliferation; Dr | 2021 |
Pulmonary toxicity of recombinant interleukin-2 plus lymphokine-activated killer cell therapy.
Topics: Adult; Carbon Monoxide; Dose-Response Relationship, Drug; Female; Humans; Immunotherapy; Interleukin | 1993 |