carbon monoxide has been researched along with Leigh Disease in 1 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Alternative experimental strategies to reduce oxygen delivery, including breathing carbon monoxide (600 ppm in air) or severe anemia, can reverse neurological disease." | 3.91 | Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. ( Ast, T; Brepoels, K; Carmeliet, P; Galkin, A; Goldberger, O; Ichinose, F; Jain, IH; Marutani, E; Mootha, VK; Schleifer, G; Schoonjans, L; Stepanova, A; Wang, H; Wojtkiewicz, GR; Zapol, WM; Zazzeron, L, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, IH | 1 |
| Zazzeron, L | 1 |
| Goldberger, O | 1 |
| Marutani, E | 1 |
| Wojtkiewicz, GR | 1 |
| Ast, T | 1 |
| Wang, H | 1 |
| Schleifer, G | 1 |
| Stepanova, A | 1 |
| Brepoels, K | 1 |
| Schoonjans, L | 1 |
| Carmeliet, P | 1 |
| Galkin, A | 1 |
| Ichinose, F | 1 |
| Zapol, WM | 1 |
| Mootha, VK | 1 |
1 other study available for carbon monoxide and Leigh Disease
| Article | Year |
|---|---|
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Topics: Anemia; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Carbon Monoxide; Disease Model | 2019 |