carbon monoxide has been researched along with Innate Inflammatory Response in 167 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to assess whether pretreatment with carbon monoxide-releasing molecule-2 (CORM-2) could ameliorate inflammation by regulating differentiation of CD4 + T cells in intestinal mucosa of rats undergoing hemorrhagic shock." | 8.12 | Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. ( Du, F; Niu, Q; Wang, X; Yang, X, 2022) |
| "The inhalation of carbon monoxide (CO) gas and the administration of CO-releasing molecules were shown to inhibit the development of intestinal inflammation in a murine colitis model." | 8.02 | Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. ( Higashimura, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Mizushima, K; Naito, Y; Okayama, T; Takagi, T; Uchiyama, K, 2021) |
| " The potential of CO-releasing molecules (CORMs), substances that release CO (Carbon monoxide) within animal tissues, for treating paraquat-induced ROS generation and inflammation is investigated here." | 8.02 | The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis. ( Chang, CY; Cheng, CH; Chiu, HY; Chuu, JJ; Huang, KC; Li, JC; Lin, LS; Wang, SM; Yeh, CH, 2021) |
| "The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO-1) cascade." | 7.96 | The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. ( El-Gowilly, SM; El-Mas, MM; Wedn, AM, 2020) |
| "Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood." | 7.85 | Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. ( Dahmen, U; Dirsch, O; Dong, W; Guo, E; Hu, J; Jiang, X; Liu, A; Liu, S; Sun, J; Yang, J; Yang, Y, 2017) |
| "Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated." | 7.81 | Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015) |
| " Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear." | 7.80 | Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014) |
| "Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae." | 7.76 | Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. ( Cheng, S; Keaney, JF; Lyass, A; Massaro, JM; O'Connor, GT; Vasan, RS, 2010) |
| "We assumed that the level of expired-air carbon monoxide may not useful in assessing the severity of inflammation in COPD (Tab." | 7.74 | Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD? ( Hanta, I; Kocabas, A; Olgunus, O; Satar, S; Seydaoglu, G, 2007) |
| "To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms." | 7.74 | [The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007) |
| " We assessed a panel of circulating biomarkers indicative of inflammation and oxidants and measured plasma nicotine and exhaled carbon monoxide (CO) levels before and after the sessions." | 5.51 | Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness. ( Araujo, JA; Brecht, ML; Cheng, CW; Dobrin, D; Gupta, R; Means, A; Nettle, CO; Rezk-Hanna, M; Tashkin, DP, 2022) |
| "Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation." | 5.48 | Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018) |
| "Resolution of acute inflammation is an active event accompanied by biosynthesis of specialized proresolving mediators (SPM)." | 5.39 | Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. ( Chiang, N; Choi, AM; Dalli, J; Kibi, M; Mirakaj, V; Serhan, CN; Shinohara, M, 2013) |
| "Sepsis is characterized by a systemic response to severe infection." | 5.35 | Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008) |
| "CO protects against systemic effects of hemorrhagic shock and resuscitation." | 5.33 | Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005) |
| "Haem-oxygenase-1 (HO-1) is an enzyme responsible for the degradation of haem that can suppress inflammation, through the production of carbon monoxide (CO)." | 4.93 | Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance. ( Alvarez-Lobos, MM; Bueno, SM; Carreño, LJ; Espinoza, JA; Kalergis, AM; Mackern-Oberti, JP; Riedel, CA; Riquelme, SA, 2016) |
| "Carbon monoxide derived from haem oxygenase (HO)-2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO-1 has anti-inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation." | 4.89 | Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics. ( Bharucha, A; Farrugia, G; Gibbons, SJ; Verhulst, PJ, 2013) |
| " Beneficial protective effects of HO-1 in inflammation are not only mediated via enzymatic degradation of proinflammatory free heme, but also via production of the anti-inflammatory compounds bilirubin and carbon monoxide." | 4.86 | Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. ( Blasczyk, R; Eiz-Vesper, B; Immenschuh, S; Paine, A, 2010) |
| "This study aimed to assess whether pretreatment with carbon monoxide-releasing molecule-2 (CORM-2) could ameliorate inflammation by regulating differentiation of CD4 + T cells in intestinal mucosa of rats undergoing hemorrhagic shock." | 4.12 | Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. ( Du, F; Niu, Q; Wang, X; Yang, X, 2022) |
| "The inhalation of carbon monoxide (CO) gas and the administration of CO-releasing molecules were shown to inhibit the development of intestinal inflammation in a murine colitis model." | 4.02 | Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. ( Higashimura, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Mizushima, K; Naito, Y; Okayama, T; Takagi, T; Uchiyama, K, 2021) |
| " The potential of CO-releasing molecules (CORMs), substances that release CO (Carbon monoxide) within animal tissues, for treating paraquat-induced ROS generation and inflammation is investigated here." | 4.02 | The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis. ( Chang, CY; Cheng, CH; Chiu, HY; Chuu, JJ; Huang, KC; Li, JC; Lin, LS; Wang, SM; Yeh, CH, 2021) |
| "The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO-1) cascade." | 3.96 | The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. ( El-Gowilly, SM; El-Mas, MM; Wedn, AM, 2020) |
| " Carbon monoxide (CO) arising from heme degradation, catalyzed particularly by heme oxygenase-1 (HO-1), has been shown to own cytoprotective effects including anti-inflammation and antioxidant." | 3.96 | Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes. ( Cheng, CY; Chu, PM; Chuang, CC; Huang, HW; Lee, IT; Lin, WN; Vo, TTT, 2020) |
| "Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood." | 3.85 | Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. ( Dahmen, U; Dirsch, O; Dong, W; Guo, E; Hu, J; Jiang, X; Liu, A; Liu, S; Sun, J; Yang, J; Yang, Y, 2017) |
| "Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated." | 3.81 | Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015) |
| " Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear." | 3.80 | Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014) |
| "Levels of a biological marker of inflammation (carbon monoxide) were assessed by measurement of end-tidal carbon monoxide (ETCO) and lung function by measurement of functional residual capacity (FRC) and compliance (Crs) and resistance (Rrs) of the respiratory system on days 3 and 14 after birth." | 3.77 | Prediction of bronchopulmonary dysplasia. ( Greenough, A; Kennedy, C; May, C; Patel, S; Peacock, JL; Pollina, E; Rafferty, GF, 2011) |
| "Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae." | 3.76 | Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. ( Cheng, S; Keaney, JF; Lyass, A; Massaro, JM; O'Connor, GT; Vasan, RS, 2010) |
| "To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms." | 3.74 | [The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007) |
| "We assumed that the level of expired-air carbon monoxide may not useful in assessing the severity of inflammation in COPD (Tab." | 3.74 | Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD? ( Hanta, I; Kocabas, A; Olgunus, O; Satar, S; Seydaoglu, G, 2007) |
| "The results demonstrate that inhaled carbon monoxide significantly reduces CPB-induced inflammation via suppression of tumor necrosis factor alpha, and interleukin-1beta expression and elevation of interleukin 10." | 3.74 | Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs. ( Doenst, T; Geiger, KK; Goebel, U; Loop, T; Mecklenburg, A; Pahl, HL; Roesslein, M; Schlensak, C; Schmidt, R; Schwer, CI; Siepe, M; Stein, P, 2008) |
| "The source of exhaled carbon monoxide (CO) and the relationship to airway inflammation are not clear." | 3.71 | Alterations in exhaled gas profile during allergen-induced asthmatic response. ( Dweik, RA; Erzurum, SC; Hammel, J; Khatri, SB; Laskowski, D; McCarthy, K; Ozkan, M, 2001) |
| "Since chronic obstructive pulmonary disease (COPD) is characterised by inflammation and oxidative stress, low-dose CO could be of therapeutic use." | 2.73 | Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. ( Bathoorn, E; Boezen, HM; Kerstjens, HA; Koeter, GH; Postma, DS; Slebos, DJ; van der Toorn, M; van Oosterhout, AJ, 2007) |
| "Carbon monoxide (CO) has long been known as a "silent killer" because of its ability to bind hemoglobin (Hb), leading to reduced oxygen carrying capacity of Hb, which is the main cause of CO poisoning (COP) in humans." | 2.72 | Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. ( Chang, CP; Chen, RJ; Chen, TH; Chen, YY; Guo, HR; Huang, CC; Lee, YH; Wang, YJ; Yeh, YL, 2021) |
| "Bilirubin proved to be an efficient free radicals scavenger and modulator of immune responses." | 2.66 | Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. ( Kapka-Skrzypczak, L; Kurzepa, J; Osiak, W; Wątroba, S, 2020) |
| "Although many diseases, including cancer, hematological diseases, hypertension, heart failure, inflammation, sepsis, neurodegeneration, and sleep disorders, have been linked to abnormal endogenous CO metabolism and functions, CO administration has therapeutic potential in inflammation, sepsis, lung injury, cardiovascular diseases, transplantation, and cancer." | 2.48 | Carbon monoxide: an unusual drug. ( Ascenzi, P; di Masi, A; Gullotta, F, 2012) |
| "Lung inflammation is a pivotal phenomenon in the pathogenesis of cystic fibrosis." | 2.44 | [Measurement of pulmonary inflammation in cystic fibrosis]. ( Abely, M; Chiron, R; Fayon, M, 2008) |
| "Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects." | 1.72 | Delivery of therapeutic carbon monoxide by gas-entrapping materials. ( Aragon, A; Becker, SL; Bi, J; Bosch, DE; Boyce, H; Byrne, JD; Coleman, MC; Cotoia, AT; Csizmadia, E; Feig, VR; Gallo, D; Hayward, A; Ishida, K; Jeck, WR; Jenkins, J; Kezar, KM; Kim, H; Kuosmanen, JLP; Langer, R; Lee, GR; Lee, JS; Longhi, MS; Lopes, A; Otterbein, LE; Shankar, S; Spitz, DR; Steiger, C; Tift, M; Traverso, G; Wainer, J; Wentworth, AJ; Witt, E; Wong, K, 2022) |
| "Psoriasis is a chronic autoimmune disease mediated by dysregulated immune responses in dendritic cells (DC) and T cells." | 1.48 | Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment. ( Campbell, NK; Dunne, A; Fitzgerald, HK; Fletcher, JM; Hambly, R; Kirby, B; Malara, A; Sweeney, CM, 2018) |
| "Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation." | 1.48 | Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018) |
| "The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation." | 1.43 | Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis. ( Agusti, A; Antó, JM; Barreiro, E; Garcia-Aymerich, J; Gómez, F; Marín, A; Monsó, E; Noguera, A; Núñez, B; Sauleda, J, 2016) |
| "procumbens in carrageenan-induced hyperalgesia in rats." | 1.42 | Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. ( Aricò, G; Chiechio, S; Di Benedetto, G; Parenti, C; Parenti, R; Scoto, GM, 2015) |
| "Carbon monoxide (CO) has been recently reported as the main anti-inflammatory mediator of the haem-degrading enzyme haem-oxygenase 1 (HO-1)." | 1.42 | Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility. ( Bueno, SM; Kalergis, AM; Riquelme, SA, 2015) |
| "Resolution of acute inflammation is an active event accompanied by biosynthesis of specialized proresolving mediators (SPM)." | 1.39 | Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. ( Chiang, N; Choi, AM; Dalli, J; Kibi, M; Mirakaj, V; Serhan, CN; Shinohara, M, 2013) |
| "Carbon monoxide (CO) has anti-inflammatory properties at low concentrations but its effects on reproductive tissues is unclear." | 1.39 | Does carbon monoxide inhibit proinflammatory cytokine production by fetal membranes? ( Hanna, N; Klimova, NG; Peltier, MR, 2013) |
| "Ozone was a predictor of C-reactive protein and ICAM-1." | 1.38 | Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. ( Baccarelli, A; Bind, MA; Schwartz, J; Suh, H; Tarantini, L; Vokonas, P; Zanobetti, A, 2012) |
| "These chronic metabolic diseases are associated with elevated inflammatory activities." | 1.37 | The role of carbon monoxide in metabolic disease. ( Chung, HT; Joe, Y; Kim, S; Kim, SK; Min, TS; Ryu, DG; Uddin, JM; Zheng, M, 2011) |
| "Sepsis is characterized by a systemic response to severe infection." | 1.35 | Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008) |
| "CO protects against systemic effects of hemorrhagic shock and resuscitation." | 1.33 | Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005) |
| "In a model of acute lung injury in mice, CO blocked expression of Egr-1, a central mediator of inflammation, and decreased tissue damage; inhibition of PPARgamma abrogated both effects." | 1.33 | Carbon monoxide orchestrates a protective response through PPARgamma. ( Bach, FH; Bilban, M; Chin, BY; d'Avila, JC; Esterbauer, H; Ifedigbo, E; Otterbein, LE; Otterbein, SL; Robson, SC; Usheva, A; Wagner, O, 2006) |
| "Arterial thrombosis is a critical event in the pathogenesis of lesion development." | 1.33 | Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. ( Chau, LY; Chen, YH; Chiang, MT; Tsai, HL, 2006) |
| "Pretreatment with aspirin or bilirubin at low micromolar concentrations protected endothelial cells from hydrogen peroxide-mediated toxicity." | 1.32 | Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. ( Abate, A; Becker, JC; Dennery, PA; Grosser, N; Oberle, S; Pohle, T; Schröder, H; Seidman, DS; Vreman, HJ, 2003) |
| "After 30 min of hemorrhagic shock, mice were resuscitated with shed blood to restore mean arterial blood pressure to baseline." | 1.31 | Hemorrhage and resuscitation induce delayed inflammation and pulmonary dysfunction in mice. ( Claridge, JA; Enelow, RI; Young, JS, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (2.99) | 18.2507 |
| 2000's | 56 (33.53) | 29.6817 |
| 2010's | 84 (50.30) | 24.3611 |
| 2020's | 22 (13.17) | 2.80 |
| Authors | Studies |
|---|---|
| Gottfried, I | 1 |
| Schottlender, N | 1 |
| Ashery, U | 1 |
| Gasier, HG | 1 |
| Suliman, HB | 3 |
| Piantadosi, CA | 3 |
| Dias-Pedroso, D | 1 |
| Ramalho, JS | 1 |
| Sardão, VA | 1 |
| Jones, JG | 1 |
| Romão, CC | 2 |
| Oliveira, PJ | 1 |
| Vieira, HLA | 1 |
| Hsu, CY | 1 |
| Vo, TTT | 2 |
| Lee, CW | 1 |
| Chen, YL | 1 |
| Lin, WN | 2 |
| Cheng, HC | 1 |
| Vo, QC | 1 |
| Lee, IT | 2 |
| Byrne, JD | 1 |
| Gallo, D | 4 |
| Boyce, H | 1 |
| Becker, SL | 1 |
| Kezar, KM | 1 |
| Cotoia, AT | 1 |
| Feig, VR | 1 |
| Lopes, A | 1 |
| Csizmadia, E | 1 |
| Longhi, MS | 1 |
| Lee, JS | 1 |
| Kim, H | 1 |
| Wentworth, AJ | 1 |
| Shankar, S | 1 |
| Lee, GR | 2 |
| Bi, J | 1 |
| Witt, E | 1 |
| Ishida, K | 1 |
| Hayward, A | 1 |
| Kuosmanen, JLP | 1 |
| Jenkins, J | 1 |
| Wainer, J | 1 |
| Aragon, A | 1 |
| Wong, K | 1 |
| Steiger, C | 1 |
| Jeck, WR | 1 |
| Bosch, DE | 1 |
| Coleman, MC | 1 |
| Spitz, DR | 1 |
| Tift, M | 1 |
| Langer, R | 1 |
| Otterbein, LE | 11 |
| Traverso, G | 1 |
| Sherman, HT | 1 |
| Liu, K | 1 |
| Kwong, K | 1 |
| Chan, ST | 1 |
| Li, AC | 1 |
| Kong, XJ | 1 |
| Cazuza, RA | 1 |
| Batallé, G | 1 |
| Bai, X | 1 |
| Leite-Panissi, CRA | 1 |
| Pol, O | 2 |
| Zhao, WM | 1 |
| Wang, ZJ | 1 |
| Shi, R | 1 |
| Zhu, YY | 1 |
| Zhang, S | 1 |
| Wang, RF | 1 |
| Wang, DG | 1 |
| Niu, Q | 3 |
| Du, F | 3 |
| Yang, X | 6 |
| Wang, X | 6 |
| Percival, E | 1 |
| Collison, AM | 1 |
| da Silva Sena, CR | 1 |
| De Queiroz Andrade, E | 1 |
| De Gouveia Belinelo, P | 1 |
| Gomes, GMC | 1 |
| Oldmeadow, C | 1 |
| Murphy, VE | 1 |
| Gibson, PG | 2 |
| Karmaus, W | 1 |
| Mattes, J | 1 |
| Leake, A | 1 |
| Salem, K | 1 |
| Madigan, MC | 1 |
| Shukla, A | 1 |
| Hong, G | 1 |
| Zuckerbraun, BS | 4 |
| Tzeng, E | 1 |
| Ryter, SW | 11 |
| Guo, D | 1 |
| Hu, H | 1 |
| Pan, S | 1 |
| Wedn, AM | 1 |
| El-Gowilly, SM | 1 |
| El-Mas, MM | 1 |
| Joe, Y | 8 |
| Chen, Y | 2 |
| Park, J | 2 |
| Kim, HJ | 3 |
| Rah, SY | 2 |
| Ryu, J | 2 |
| Cho, GJ | 4 |
| Choi, HS | 1 |
| Park, JW | 1 |
| Kim, UH | 2 |
| Chung, HT | 10 |
| Yang, PM | 1 |
| Cheng, KC | 1 |
| Yuan, SH | 1 |
| Wung, BS | 1 |
| Cheng, CY | 1 |
| Huang, HW | 1 |
| Chuang, CC | 1 |
| Chu, PM | 1 |
| Osiak, W | 1 |
| Wątroba, S | 1 |
| Kapka-Skrzypczak, L | 1 |
| Kurzepa, J | 1 |
| Takagi, T | 2 |
| Naito, Y | 2 |
| Higashimura, Y | 1 |
| Uchiyama, K | 1 |
| Okayama, T | 1 |
| Mizushima, K | 2 |
| Katada, K | 1 |
| Kamada, K | 1 |
| Ishikawa, T | 1 |
| Itoh, Y | 1 |
| Campbell, NK | 2 |
| Fitzgerald, HK | 2 |
| Dunne, A | 2 |
| Chen, RJ | 1 |
| Lee, YH | 1 |
| Chen, TH | 1 |
| Chen, YY | 1 |
| Yeh, YL | 1 |
| Chang, CP | 1 |
| Huang, CC | 1 |
| Guo, HR | 1 |
| Wang, YJ | 1 |
| Huang, KC | 1 |
| Li, JC | 1 |
| Wang, SM | 1 |
| Cheng, CH | 1 |
| Yeh, CH | 1 |
| Lin, LS | 1 |
| Chiu, HY | 1 |
| Chang, CY | 1 |
| Chuu, JJ | 1 |
| Rezk-Hanna, M | 1 |
| Gupta, R | 1 |
| Nettle, CO | 1 |
| Dobrin, D | 1 |
| Cheng, CW | 1 |
| Means, A | 1 |
| Brecht, ML | 1 |
| Tashkin, DP | 1 |
| Araujo, JA | 1 |
| Shefa, U | 1 |
| Yeo, SG | 1 |
| Kim, MS | 2 |
| Song, IO | 1 |
| Jung, J | 1 |
| Jeong, NY | 1 |
| Huh, Y | 1 |
| Wallace, JL | 3 |
| Ianaro, A | 2 |
| de Nucci, G | 1 |
| Schallner, N | 1 |
| Lieberum, JL | 1 |
| LeBlanc, RH | 1 |
| Fuller, PM | 1 |
| Hanafy, KA | 1 |
| Lee, DW | 1 |
| Shin, HY | 1 |
| Jeong, JH | 1 |
| Han, J | 1 |
| Ryu, S | 1 |
| Nakahira, K | 4 |
| Moon, JS | 1 |
| Mangano, K | 2 |
| Cavalli, E | 1 |
| Mammana, S | 1 |
| Basile, MS | 1 |
| Caltabiano, R | 1 |
| Pesce, A | 1 |
| Puleo, S | 1 |
| Atanasov, AG | 1 |
| Magro, G | 1 |
| Nicoletti, F | 2 |
| Fagone, P | 2 |
| Bauer, B | 1 |
| Göderz, AL | 1 |
| Braumüller, H | 1 |
| Neudörfl, JM | 1 |
| Röcken, M | 1 |
| Wieder, T | 1 |
| Schmalz, HG | 2 |
| Wu, J | 1 |
| Zhang, R | 1 |
| Hu, G | 1 |
| Zhu, HH | 1 |
| Gao, WQ | 1 |
| Xue, J | 2 |
| Belcher, JD | 3 |
| Chen, C | 3 |
| Nguyen, J | 3 |
| Abdulla, F | 2 |
| Zhang, P | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cognitive Improvement After cARotid stEnting in HyperBaric Oxygen Therapy Trial (CARE-HBOT)[NCT05980195] | 90 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | |||
| The Effects of Probiotics and Oxytocin Nasal Spray on Social Behaviors of ASD Children- A Pilot Study[NCT03337035] | Phase 1 | 35 participants (Actual) | Interventional | 2018-12-01 | Completed | ||
| Investigating the Cardiovascular Toxicity of Exposure to Electronic Hookah Smoking[NCT03690427] | 19 participants (Actual) | Interventional | 2018-12-11 | Completed | |||
| A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001] | Phase 2 | 0 participants (Actual) | Interventional | 2013-10-31 | Withdrawn (stopped due to Sangart ceased operations) | ||
| Pravastatin to Prevent Preeclampsia and Reduce Maternal-Neonatal Mortality and Morbidity in High Risk Preeclampsia Patients[NCT03648970] | Phase 2 | 280 participants (Anticipated) | Interventional | 2018-03-01 | Recruiting | ||
| Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nasal Lavage and miRNAs in Blood[NCT02136550] | 36 participants (Anticipated) | Interventional | 2013-02-28 | Active, not recruiting | |||
| The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers[NCT04688177] | 52 participants (Actual) | Observational | 2020-12-03 | Completed | |||
| Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers[NCT02469428] | 14 participants (Actual) | Interventional | 2013-12-31 | Completed | |||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311] | Phase 4 | 70 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337] | Phase 4 | 37 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Pulmonary Abnormalities, Diastolic Dysfunction, and World Trade Center Exposure: Implications for Diagnosis and Treatment[NCT01466218] | 1,012 participants (Actual) | Observational | 2011-11-30 | Completed | |||
| Measuring Knowledge and Behavior After an Educational Program on Air Pollution as a Health Risk Reduction Strategy[NCT04563052] | 40 participants (Actual) | Interventional | 2020-01-28 | Completed | |||
| Modification of Chronic Inflammation by Inhaled Carbon Monoxide in Patients With Stable COPD[NCT00122694] | Phase 2 | 20 participants | Interventional | 2005-01-31 | Completed | ||
| A Phase Ib Trial of Inhaled Carbon Monoxide for the Treatment of Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)[NCT04870125] | Phase 1 | 36 participants (Anticipated) | Interventional | 2023-12-06 | Recruiting | ||
| Asthma Inflammation Research[NCT01536522] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2011-01-31 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Serum IL-10 (anti-inflammatory biomarker) (NCT03690427)
Timeframe: A change between two points is reported below (e.g., value at post-exposure session minus value at pre-exposure session).
| Intervention | pg/mL (Mean) |
|---|---|
| Electronic Hookah | 0.03 |
| Traditional Hookah | -0.01 |
Plasma IL-6 (inflammatory biomarker). (NCT03690427)
Timeframe: A change between two points is reported below (e.g., value at post-exposure session minus value at pre-exposure session).
| Intervention | pg/mL (Mean) |
|---|---|
| Electronic Hookah | 0.13 |
| Traditional Hookah | 0.04 |
"Arylesterase activity (lipid peroxidation biomarker) was determined by the rate of hydrolysis of phenyl acetate to phenol. Briefly, 4 mL plasma was incubated with 3.5 mM phenyl acetate in 9 mM Tris-HCl buffer (pH, 8.0) containing 0.9 mM CaCl2 at RT. The kinetics of phenol formation were determined by recording the absorbance at 270 nm every 15 s for 2 min.~Unit of Measure: nanomoles of product formed per minute per milliliter of plasma." (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions.
| Intervention | units/mL:see Outcome Measure Description (Mean) | |
|---|---|---|
| Arylesterase activity before exposure session | Arylesterase activity after exposure session | |
| Electronic Hookah | 277.36 | 295.78 |
| Traditional Hookah | 281.38 | 285.06 |
AI was used to measure central stiffness. It was calculated as the ratio of augmentation pressure (difference between the second and first systolic peaks of the aortic pressure waveform) and pulse pressure expressed as a percentage. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | percentage of the pulse pressure (Mean) | |
|---|---|---|
| AI before exposure session | AI after exposure session | |
| Electronic Hookah | 7.97 | 13.55 |
| Traditional Hookah | 7.79 | 10.66 |
Exhaled CO levels (smoking or vaping exposure biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | ppm (Mean) | |
|---|---|---|
| CO before exposure session | CO after exposure session | |
| Electronic Hookah | 2.58 | 2.31 |
| Traditional Hookah | 3.38 | 40.19 |
Using applanation tonometry, cf-PWV was used to measure central arterial stiffness. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | m/sec (Mean) | |
|---|---|---|
| cf-PWV before exposure session | cf-PWV after exposure session | |
| Electronic Hookah | 8.20 | 8.94 |
| Traditional Hookah | 8.15 | 8.71 |
As a control test for the assessment of endothelium-dependent vasodilator function, using ultrasound the brachial artery, endothelium-independent dilatation was assessed by administering sublingual nitroglycerin. This measure was assessed 10 minutes after FMD testing. Ultrasound images were recorded continuously for a total of 10 minutes (NCT03690427)
Timeframe: Pre- and post- sublingual administration of nitroglycerin (0.15 mg), which was administrated before and after e-hookah vaping.
| Intervention | percentage of arterial diameter (Mean) | |
|---|---|---|
| Dilation before e-hookah vaping | Dilation after e-hookah vaping | |
| Electronic Hookah | 27.15 | 25.17 |
Using ultrasound, FMD of the brachial artery induced by reactive hyperemia, was used to measure endothelium-dependent vasodilator function. Baseline diameter and velocity were recorded for 45 seconds and resumed 30 seconds before cuff deflation and continuously for 2 minutes after deflation to obtain true peak vasodilatory response. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | percentage of arterial diameter (Mean) | |
|---|---|---|
| FMD before exposure session | FMD after exposure session | |
| Electronic Hookah | 6.11 | 4.79 |
| Traditional Hookah | 5.89 | 7.31 |
Using ultrasound, FMD of the brachial artery, induced by reactive hyperemia, was used to measure endothelium-dependent vasodilator function after intravenous infusion of antioxidant ascorbic acid. Infusion of antioxidant ascorbic acid was done before the e-hookah vaping session. (NCT03690427)
Timeframe: Effect of FMD with e-hookah vaping examined after pretreatment of intravenous infusion of antioxidant ascorbic acid (administered over 60 minutes at 0.5 mL min-1)
| Intervention | percentage of arterial diameter (Mean) | |
|---|---|---|
| FMD before e-hookah vaping | FMD after e-hookah vaping | |
| Electronic Hookah | 9.46 | 8.74 |
Capacity was determined as the ability of HDL to inhibit LDL-induced oxidation of dihydrodichlorofluorescein into the fluorescent dichlorofluorescein. Capacity was expressed as an HDL oxidative index, determined by the ratio of dichlorofluorescein fluorescence in the presence and absence of HDL. An index of < 1.0 denotes protective antioxidant HDL, whereas an index of > 1.0 indicates pro-oxidant HDL. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | index (Mean) | |
|---|---|---|
| HOI before exposure session | HOI after exposure session | |
| Electronic Hookah | 0.57 | 0.58 |
| Traditional Hookah | 0.56 | 0.52 |
Plasma hs-CRP (inflammatory biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | mg/L (Mean) | |
|---|---|---|
| hs-CRP before exposure session | hs-CRP after exposure session | |
| Electronic Hookah | 0.72 | 0.76 |
| Traditional Hookah | 0.77 | 0.77 |
Plasma nicotine levels (smoking or vaping exposure biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | ng/mL (Mean) | |
|---|---|---|
| Plasma nicotine before exposure session | Plasma nicotine after exposure session | |
| Electronic Hookah | 0.59 | 5.83 |
| Traditional Hookah | 0.82 | 6.96 |
"PON-1 activity was determined by the ability of PON-1, associated with HDL, to hydrolyze paraoxon substrate. The hydrolysis of paraoxon (diethyl-p-nitrophenyl phosphate) to p-nitrophenol by PON-1 was determined by incubating 5 mL of plasma with 1.0 mM paraoxon in 100 mM tris-HCl buffer (pH, 8.5).~Unit of Measure: expressed as micromoles of p-nitrophenol formed per minute for every 1 mL plasma." (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | units/mL:see Outcome Measure Description (Mean) | |
|---|---|---|
| PON-1 before exposure session | PON-1 after exposure session | |
| Electronic Hookah | 1071.24 | 1151.73 |
| Traditional Hookah | 709.32 | 701.29 |
Plasma TNFα (inflammatory biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions
| Intervention | pg/mL (Mean) | |
|---|---|---|
| TNFα before exposure session | TNFα after exposure session | |
| Electronic Hookah | 0.69 | 0.76 |
| Traditional Hookah | 0.85 | 0.82 |
Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| Arm 1 of 5 Randomized Treatment Arms | 27.6 |
| Arm 2 of 5 Randomized Treatment Arms | 27.0 |
| Arm 3 of 5 Randomized Treatment Arms | 31.4 |
| Arm 4 of 5 Randomized Treatment Arms | 25.7 |
| Arm 5 of 5 Randomized Treatment Arms | 28.3 |
Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| 1 of 5 Randomized Treatment Arms | 10.0 |
| 2 of 5 Randomized Treatment Arms | 11.2 |
| 3 of 5 Randomized Treatment Arms | 10.0 |
| 4 of 5 Randomized Treatment Arms | 11.0 |
| 5 of 5 Randomized Treatment Arms | 9.6 |
47 reviews available for carbon monoxide and Innate Inflammatory Response
| Article | Year |
|---|---|
Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.
Topics: Aged; Brain; Carbon Monoxide; Cognition; Humans; Hyperbaric Oxygenation; Inflammation; Mitochondria; | 2021 |
Environmental factors influencing the risk of ANCA-associated vasculitis.
Topics: Air Pollutants; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutroph | 2022 |
Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation.
Topics: Animals; Autophagy; Carbon Monoxide; Heme Oxygenase-1; Humans; Inflammation; Mitochondria | 2019 |
Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases.
Topics: Bilirubin; Carbon Monoxide; Heme; Humans; Infant, Newborn; Infant, Newborn, Diseases; Inflammation; | 2020 |
Regulation of inflammation by the antioxidant haem oxygenase 1.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Monoxide; Dendritic Cells; Enzyme Induction; | 2021 |
Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes.
Topics: Animals; Autophagy; Biomarkers; Carbon Monoxide; Carbon Monoxide Poisoning; Cytokines; Exosomes; Hum | 2021 |
Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair.
Topics: Alzheimer Disease; Carbon Monoxide; Cardiovascular System; Gasotransmitters; Humans; Hydrogen Sulfid | 2017 |
Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury.
Topics: Animals; Carbon Monoxide; Gasotransmitters; Gastric Mucosa; Gastrointestinal Agents; Gastrointestina | 2017 |
Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?
Topics: Acute Lung Injury; Animals; Capillary Permeability; Carbon Monoxide; Cytokines; Disease Models, Anim | 2018 |
[Role Ofhydrogen Sulfide on Inflammatory Immune Disorders in Cardiovascular Diseases].
Topics: Carbon Monoxide; Cardiovascular Diseases; Humans; Hydrogen Sulfide; Immune System Diseases; Inflamma | 2017 |
Carbon monoxide in exhaled breath testing and therapeutics.
Topics: Acute Lung Injury; Anesthesia; Animals; Asthma; Biomarkers; Breath Tests; Carbon Monoxide; Cystic Fi | 2013 |
Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Gastrointestinal Diseases; Gastrointestinal Trac | 2013 |
Heme oxygenase-1 as a target for drug discovery.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Drug Discovery; Enzyme Induction; Heme Oxygenase | 2014 |
Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress.
Topics: Animals; Carbon Monoxide; Cell Survival; Energy Metabolism; Humans; Hydrogen Sulfide; Inflammation; | 2014 |
CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation.
Topics: Acute Disease; Animals; Carbon Monoxide; Cytokines; Gastrointestinal Diseases; Gastrointestinal Trac | 2015 |
Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm?
Topics: Animals; Carbon Monoxide; Drug Design; Female; Humans; Hydrogen Sulfide; Inflammation; Oxidative Str | 2015 |
Protective role of hemeoxygenase-1 in gastrointestinal diseases.
Topics: Animals; Biliverdine; Carbon Monoxide; Gastrointestinal Diseases; Gastrointestinal Tract; Gene Expre | 2015 |
Gaseous mediators in resolution of inflammation.
Topics: Anti-Inflammatory Agents; Apoptosis; Carbon Monoxide; Cytoprotection; Gasotransmitters; Homeostasis; | 2015 |
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Genetic Therapy; Heme Oxygenase-1; Humans; Infla | 2016 |
Gaseous mediator-based anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Gasotransmitters; Humans; Hydroge | 2015 |
Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea.
Topics: Biomarkers; Breath Tests; Carbon Monoxide; Humans; Inflammation; Nitric Oxide; Sleep Apnea, Obstruct | 2016 |
Carbon monoxide in the treatment of sepsis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Heme Oxygenase (Decyclizing); Humans; Inflammati | 2015 |
Mitochondrial Quality Control as a Therapeutic Target.
Topics: Carbon Monoxide; Erythropoietin; Estrogens; Free Radical Scavengers; Heme Oxygenase-1; Humans; Hydro | 2016 |
Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance.
Topics: Animals; Antigen Presentation; Carbon Monoxide; Drug Design; Heme Oxygenase-1; Humans; Immune System | 2016 |
Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities.
Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cardiovascular Agents; Cardiovascular Diseases; Ch | 2008 |
[Measurement of pulmonary inflammation in cystic fibrosis].
Topics: Adult; Age Factors; Antioxidants; Biopsy; Breath Tests; Bronchi; Bronchoalveolar Lavage; Carbon Mono | 2008 |
Hemoxygenase-1 in cardiovascular disease.
Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Cardiovascular Diseases; Diabetes Mellitus; Heme | 2008 |
Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy.
Topics: Animals; Carbon Monoxide; Drug Delivery Systems; Heme Oxygenase-1; Humans; Hypersensitivity; Inflamm | 2008 |
Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!
Topics: Animals; Carbon Monoxide; Cardiovascular System; Humans; Hydrogen Sulfide; Inflammation; Nitric Oxid | 2009 |
Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule.
Topics: Animals; Anti-Infective Agents; Carbon Monoxide; Carbon Monoxide Poisoning; Humans; Inflammation; My | 2009 |
Subtle interplay of endogenous bioactive gases (NO, CO and H(2)S) in inflammation.
Topics: Animals; Carbon Monoxide; Heme Oxygenase-1; Humans; Hydrogen Sulfide; Inflammation; Mitogen-Activate | 2009 |
Mechanisms of cell protection by heme oxygenase-1.
Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cytoprotection; Gene Expression Regulation, Enzymo | 2010 |
Carbon monoxide: endogenous mediator, potential diagnostic and therapeutic target.
Topics: Animals; Biomarkers; Carbon Monoxide; Cardiovascular Diseases; Exhalation; Gene Expression; Heme Oxy | 2010 |
Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential.
Topics: Animals; Anti-Inflammatory Agents; Bilirubin; Carbon Monoxide; Endothelial Cells; Endothelium, Vascu | 2010 |
The therapeutic potential of carbon monoxide.
Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Homeostasis; Humans; Inflammation; Organ Transpla | 2010 |
The role of brain gaseous transmitters in the regulation of the circulatory system.
Topics: Animals; Blood Circulation; Brain; Carbon Monoxide; Hydrogen Sulfide; Inflammation; Nitric Oxide | 2011 |
Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer.
Topics: Animals; Autoimmune Diseases; Carbon Monoxide; Cross-Priming; Cytoprotection; Heme Oxygenase-1; Huma | 2011 |
Therapeutic potential of carbon monoxide in multiple sclerosis.
Topics: Animals; Anti-Inflammatory Agents; Autoimmunity; Boranes; Carbon Monoxide; Carbonates; Cardiotonic A | 2012 |
Carbon monoxide: an unusual drug.
Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Enzyme Induction; Heme Oxygenase-1; Humans; Infla | 2012 |
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.
Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi | 2004 |
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.
Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi | 2004 |
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.
Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi | 2004 |
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.
Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi | 2004 |
Heme oxygenase-1 and cardiovascular disease.
Topics: Animals; Atherosclerosis; Bilirubin; Cadmium Chloride; Carbon Monoxide; Cardiovascular Diseases; Cel | 2006 |
Carbon monoxide: the bad and the good side of the coin, from neuronal death to anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Carbon Monoxide Poisoning; Cell Death; Heme Oxyg | 2006 |
[Inflammation and oxidative stress].
Topics: Carbon Monoxide; Cytokines; Free Radicals; Heme Oxygenase-1; Humans; Inflammation; Inflammation Medi | 2006 |
Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities.
Topics: Carbon Monoxide; Humans; Inflammation; Ischemia; Lipids; Solubility; Vasodilation | 2007 |
Spotlight on microcirculation: an update.
Topics: Aging; Animals; Carbon Monoxide; Cardiovascular Diseases; Endothelium, Vascular; Endotoxemia; Humans | 1999 |
Gas analysis.
Topics: Adult; Age Factors; Asthma; Biomarkers; Breath Tests; Carbon Monoxide; Child; Cystic Fibrosis; Elect | 2000 |
Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule.
Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cell Hypoxia; Disease | 2002 |
5 trials available for carbon monoxide and Innate Inflammatory Response
| Article | Year |
|---|---|
Carbon monoxide (CO) correlates with symptom severity, autoimmunity, and responses to probiotics treatment in a cohort of children with autism spectrum disorder (ASD): a post-hoc analysis of a randomized controlled trial.
Topics: Autism Spectrum Disorder; Autoantibodies; Autoimmunity; Biomarkers; Carbon Monoxide; Child; Humans; | 2022 |
The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers.
Topics: Air Pollutants; Air Pollution; Ammonia; Asthma; Carbon Monoxide; Female; Humans; Infant; Inflammatio | 2023 |
Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness.
Topics: Adult; Antioxidants; Aryldialkylphosphatase; C-Reactive Protein; Carbon Monoxide; Carboxylic Ester H | 2022 |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women.
Topics: Adult; Air Pollutants; Carbon Monoxide; Cohort Studies; Cross-Sectional Studies; Female; Fibronectin | 2014 |
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo | 2007 |
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo | 2007 |
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo | 2007 |
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo | 2007 |
115 other studies available for carbon monoxide and Innate Inflammatory Response
| Article | Year |
|---|---|
The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle.
Topics: Carbon Monoxide; Humans; Inflammation; Muscle, Skeletal; Stress, Physiological | 2022 |
Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells.
Topics: Animals; Carbon Monoxide; Inflammation; Lipopolysaccharides; Mice; Microglia; Neuroglobin; Nitric Ox | 2022 |
Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells.
Topics: Angiotensin II; Anti-Inflammatory Agents; Carbon Monoxide; Humans; Inflammation; Interleukin-6; Janu | 2022 |
Delivery of therapeutic carbon monoxide by gas-entrapping materials.
Topics: Animals; Carbon Monoxide; Colitis; Gases; Inflammation; Inflammatory Bowel Diseases; Swine | 2022 |
Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Carbon Monoxide; Central Nervous System; Chronic | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock.
Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi | 2022 |
Systemic vasoprotection by inhaled carbon monoxide is mediated through prolonged alterations in monocyte/macrophage function.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cells | 2020 |
Oligodendrocyte dysfunction and regeneration failure: A novel hypothesis of delayed encephalopathy after carbon monoxide poisoning.
Topics: Animals; Astrocytes; Axons; Brain; Brain Diseases; Carbon Monoxide; Carbon Monoxide Poisoning; Cell | 2020 |
The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Endotoxemia; Female; Heme Oxygena | 2020 |
Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Autophagosomes; Calcium; Carbon Monoxi | 2020 |
Carbon monoxide‑releasing molecules protect against blue light exposure and inflammation in retinal pigment epithelial cells.
Topics: Apoptosis; Carbon Monoxide; Cell Line; Cell Survival; Glutathione Disulfide; Humans; Inflammation; L | 2020 |
Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes.
Topics: Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Humans; Inflammasomes; | 2020 |
Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.
Topics: Administration, Rectal; Animals; Carbon Monoxide; Cells, Cultured; Chemokine CXCL1; Colitis; Colon; | 2021 |
The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis.
Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Cell Line; Cell Survival; Dose-Response Relationship, | 2021 |
Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice.
Topics: Animals; Apoptosis; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Carbo | 2017 |
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages.
Topics: Animals; Carbon Monoxide; Glycolysis; Hyperglycemia; Inflammasomes; Inflammation; Macrophages; Male; | 2017 |
Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis.
Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Concanavalin A; Cytokines; Disease Models, Animal; He | 2018 |
Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Crystallography, X-Ray; Dendritic | 2017 |
Carbon Monoxide Impairs CD11b
Topics: Animals; Antigens, Ly; Carbon Monoxide; CD11b Antigen; Cell Movement; Chemokine CCL2; Disease Models | 2018 |
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.
Topics: Aldehydes; Anemia, Sickle Cell; Animals; Carbon Monoxide; Cytokines; Disease Models, Animal; Female; | 2018 |
Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity.
Topics: Animals; Anti-Inflammatory Agents; Biomimetics; Carbon Monoxide; Cell Line; Cytokines; Disease Model | 2018 |
Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.
Topics: Abietanes; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cell Differentiation; Cell Prol | 2018 |
Circadian clock disruption by selective removal of endogenous carbon monoxide.
Topics: Animals; Carbon Monoxide; Circadian Clocks; CLOCK Proteins; Gene Expression Regulation; Inflammation | 2018 |
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Antisickling Agents; Carbon Monoxide; Disease Mo | 2018 |
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.
Topics: Active Transport, Cell Nucleus; Animals; Antimetabolites; Autophagy; Basic Helix-Loop-Helix Leucine | 2018 |
HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Monoxide; Cells, Cultured; Cytokines; Diseas | 2019 |
A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbon Dioxide; Carbon Monoxide; Cell Line | 2019 |
An H
Topics: Carbon Monoxide; Fluorescence; Hydrogen Sulfide; Inflammation; Magnetic Resonance Spectroscopy; Mass | 2019 |
Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.
Topics: Animals; Apoptosis; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Humans; Inflammation; Inflam | 2013 |
Short-term chamber exposure to low doses of two kinds of wood smoke does not induce systemic inflammation, coagulation or oxidative stress in healthy humans.
Topics: Adult; Air Pollutants; Biomarkers; Blood Coagulation; Carbon Dioxide; Carbon Monoxide; Female; Human | 2013 |
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Disease Models, Animal; Female; Guaiacol; Heme Oxygen | 2013 |
Does carbon monoxide inhibit proinflammatory cytokine production by fetal membranes?
Topics: Amnion; Anti-Inflammatory Agents; Bacterial Infections; Carbon Monoxide; Chorion; Cytokines; Decidua | 2013 |
Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carbon Monoxide; Cell Prolif | 2014 |
Treatment with a carbon monoxide-releasing molecule inhibits chronic inflammatory pain in mice: nitric oxide contribution.
Topics: Animals; Carbon Monoxide; Chronic Pain; Freund's Adjuvant; Heme Oxygenase-1; Hyperalgesia; Inflammat | 2014 |
Effect of carbon monoxide-releasing molecules II-liberated CO on suppressing inflammatory response in sepsis by interfering with nuclear factor kappa B activation.
Topics: Animals; Carbon Monoxide; Cell Adhesion; Human Umbilical Vein Endothelial Cells; Humans; Inflammatio | 2013 |
Carbon monoxide protects against hepatic ischemia/reperfusion injury via ROS-dependent Akt signaling and inhibition of glycogen synthase kinase 3β.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Cyclic AMP Response Element-Binding Protein; E | 2013 |
Carbon monoxide-releasing molecule 3 inhibits myeloperoxidase (MPO) and protects against MPO-induced vascular endothelial cell activation/dysfunction.
Topics: Carbon Monoxide; Cell Adhesion; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endot | 2014 |
Carbon monoxide-releasing molecule-A1 inhibits Th1/Th17 and stimulates Th2 differentiation in vitro.
Topics: Animals; Antibodies; Apoptosis; Boranes; Carbon Monoxide; Carbonates; CD28 Antigens; CD3 Complex; Ce | 2014 |
Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation.
Topics: Apoptosis; Carbon Monoxide; Coordination Complexes; Cyclohexanones; Gene Expression Regulation; Huma | 2014 |
Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility.
Topics: Animals; Antimetabolites; Carbon Monoxide; Cell Movement; Dendritic Cells; Enzyme Activation; Heme O | 2015 |
Occupational exposures, smoking and airway inflammation in refractory asthma.
Topics: Aged; Asthma; Asthma, Occupational; Australia; Breath Tests; Carbon Monoxide; Cell Count; Female; Hu | 2014 |
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Monoxide; Cytoskeletal Proteins; Disease Model | 2015 |
Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carbon Monoxide; Cytokines; Female; Inflamm | 2015 |
Ambient carbon monoxide associated with alleviated respiratory inflammation in healthy young adults.
Topics: Adult; Air Pollutants; Biomarkers; Breath Tests; Carbon Monoxide; China; Exhalation; Female; Humans; | 2016 |
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats.
Topics: Analgesics; Animals; Carbon Monoxide; Carrageenan; Harpagophytum; Heme Oxygenase (Decyclizing); Hype | 2015 |
Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses.
Topics: Animals; Brain Injuries; Carbon Monoxide; Carbon Monoxide Poisoning; Edema; Erythropoietin; Hippocam | 2016 |
Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Cytokines; Disease Models, Anim | 2015 |
Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Carbon Dioxide; Carbon Monoxide; Cohort Studi | 2016 |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
Topics: Adult; Carbon Monoxide; Cell Count; Cotinine; Female; Humans; Inflammation; Interleukin-6; Interleuk | 2016 |
Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cell Survival; Drug Carriers; Drug Delivery Syst | 2016 |
Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus.
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Monoxide; Cell Line; Glycolysis; Heme Oxygenase-1; In | 2017 |
Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats.
Topics: Acetylation; Animals; Carbazoles; Carbon Monoxide; HMGB1 Protein; Inflammation; Liver; Liver Transpl | 2017 |
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
Topics: Animals; Behavior, Animal; Carbon Monoxide; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; | 2008 |
Carbon monoxide inhalation ameliorates conditions of lung grafts from rat brain death donors.
Topics: Administration, Inhalation; Animals; Apoptosis; Brain Death; Carbon Monoxide; Extracellular Signal-R | 2008 |
Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats.
Topics: Animals; Animals, Genetically Modified; Carbon Monoxide; Flow Cytometry; Genes, Reporter; Green Fluo | 2008 |
Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Apoptosis; Bilirubin; Carbon Monoxide; Cells, Cultured; Cerebral Cortex; | 2009 |
Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1.
Topics: Animals; Arthritis, Experimental; Carbon Monoxide; Cartilage, Articular; Chemokine CCL2; Collagen; F | 2009 |
Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress.
Topics: Animals; Carbon Monoxide; Cytokines; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Inflammation; | 2009 |
Exhaled carbon monoxide as a noninvasive marker of airway neutrophilia after lung transplantation.
Topics: Adult; Airway Obstruction; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; C-Reactive Protei | 2009 |
Focus on carbon monoxide: a modulator of neutrophil oxidants and elastase spatial localization?
Topics: Animals; Carbon Monoxide; Humans; Inflammation; Leukocyte Elastase; Neutrophils; Oxidants | 2009 |
Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Apoptosis; Brain Death; Carbon Monoxide; Cas | 2010 |
Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community.
Topics: Adult; Carbon Monoxide; Cardiovascular Diseases; Cross-Sectional Studies; Data Collection; Exhalatio | 2010 |
Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation.
Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Carboxyhemoglobin; Cells, Cultured; Disease Model | 2010 |
[Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury].
Topics: Animals; Carbon Monoxide; Down-Regulation; Inflammation; Intercellular Adhesion Molecule-1; Intestin | 2009 |
Prediction of bronchopulmonary dysplasia.
Topics: Biomarkers; Birth Weight; Breath Tests; Bronchopulmonary Dysplasia; Carbon Monoxide; Female; Functio | 2011 |
An increase in exhaled CO concentration in systemic inflammation/sepsis.
Topics: Anesthesia; Biomarkers; Breath Tests; Carbon Monoxide; Critical Illness; Exhalation; Heme Oxygenase- | 2010 |
Inflammatory markers: exhaled nitric oxide and carbon monoxide during the ovarian cycle.
Topics: Adult; Breath Tests; Carbon Monoxide; Exhalation; Female; Humans; Inflammation; Male; Menstrual Cycl | 2012 |
Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response.
Topics: Animals; Blotting, Western; C-Reactive Protein; Carbon Monoxide; Endoplasmic Reticulum; Enzyme-Linke | 2011 |
The role of carbon monoxide in metabolic disease.
Topics: Animals; Apoptosis; Carbon Monoxide; Endoplasmic Reticulum; Heme Oxygenase-1; Humans; Inflammation; | 2011 |
Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; Carbon Monoxide; Cold Temperature; Cytosol; Death; Gluta | 2012 |
Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.
Topics: Animals; Carbon Monoxide; Early Growth Response Protein 1; Gene Expression; Inflammation; Ion Channe | 2011 |
Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration.
Topics: Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Chemokines; Down-Regulation; Enzyme Acti | 2012 |
Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort.
Topics: Aged; Air Pollution; Biomarkers; Blood Coagulation Disorders; C-Reactive Protein; Carbon; Carbon Mon | 2012 |
Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.
Topics: Animals; Antimetabolites; Antimicrobial Cationic Peptides; Blotting, Western; Carbon Monoxide; Carci | 2012 |
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice.
Topics: Adipose Tissue; Adiposity; Animals; Bilirubin; Blotting, Western; Carbon Monoxide; Cell Movement; Di | 2012 |
Air pollution and autonomic and vascular dysfunction in patients with cardiovascular disease: interactions of systemic inflammation, overweight, and gender.
Topics: Aged; Air Pollutants; Air Pollution; Autonomic Nervous System Diseases; Blood Pressure Monitoring, A | 2012 |
Preconditioning triggered by carbon monoxide (CO) provides neuronal protection following perinatal hypoxia-ischemia.
Topics: Animals; Apoptosis; Carbon Monoxide; Carotid Artery, Common; Caspase 3; Cells, Cultured; Hippocampus | 2012 |
Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; C-Reactive Protein; Carbon Monoxide; Cross-Sectional St | 2013 |
Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats.
Topics: Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Fe | 2013 |
Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility.
Topics: Animals; Bethanechol; Blotting, Northern; Carbon Monoxide; Cyclooxygenase 2; Cytokines; Gastrointest | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice.
Topics: Adenoviridae; Animals; Apoptosis; Carbon Monoxide; Enzyme Induction; Genetic Therapy; Heme Oxygenase | 2003 |
Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study.
Topics: Air Pollutants; Carbon Monoxide; Cardiovascular Diseases; Dust; Environmental Monitoring; Factor VII | 2005 |
Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages.
Topics: Animals; Carbon Monoxide; Cell Line; Cell Survival; Glutathione; Heme Oxygenase (Decyclizing); Heme | 2005 |
Carbon monoxide protects against the development of experimental necrotizing enterocolitis.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Carbon Monoxide; Cell Culture Tech | 2005 |
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.
Topics: Adenosine Triphosphate; Air; Animals; Carbon Monoxide; Cell Death; Cell Survival; Cytokines; Disease | 2005 |
Portal hypertension produces an evolutive hepato-intestinal pro- and anti-inflammatory response in the rat.
Topics: Animals; Carbon Monoxide; Collateral Circulation; Heme Oxygenase (Decyclizing); Hypertension, Portal | 2005 |
Carbon monoxide orchestrates a protective response through PPARgamma.
Topics: Animals; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Early Growth Response Protein 1 | 2006 |
Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice.
Topics: Animals; Apolipoproteins E; Carbon Monoxide; Carotid Artery, Common; Fibrin; Fibrinogen; Heme Oxygen | 2006 |
ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cell Culture Techniques; Cell Line; Enzyme Activ | 2006 |
Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation.
Topics: Animals; Biliverdine; Carbon Monoxide; Carrageenan; Cell Adhesion; Cell Movement; Deuteroporphyrins; | 2006 |
Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction.
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; CD3 Complex; Cytokines; Dendritic Cells; Enzyme-Linked | 2006 |
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carbon Monoxide; Endothelial Cells; E | 2007 |
Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice.
Topics: Animals; Burns; Carbon Monoxide; Cell Adhesion; Inflammation; Intercellular Adhesion Molecule-1; Lun | 2007 |
A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia.
Topics: Animals; Carbon Monoxide; Cell Line; Cell Survival; Enzyme Activation; Guanylate Cyclase; Heme Oxyge | 2006 |
The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells.
Topics: Anti-Inflammatory Agents; Caco-2 Cells; Carbon Monoxide; CCAAT-Enhancer-Binding Proteins; Cytokines; | 2007 |
Effect of smoking cessation on markers of inflammation and endothelial cell activation among individuals with high risk for cardiovascular disease.
Topics: Adult; Biomarkers; C-Reactive Protein; Carbon Monoxide; Cardiovascular Diseases; Endothelial Cells; | 2007 |
Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD?
Topics: Aged; Breath Tests; Carbon Monoxide; Female; Forced Expiratory Volume; Humans; Inflammation; Male; M | 2007 |
[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns].
Topics: Animals; Burns; Carbon Monoxide; Cell Adhesion; Disease Models, Animal; Inflammation; Intercellular | 2007 |
Anti-inflammatory effects of HO-1 activity in vascular endothelial cells, commentary on "Carbon monoxide donors or heme oxygenase (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death".
Topics: Carbon Monoxide; Cell Death; Endothelium, Vascular; Heme Oxygenase-1; Humans; Inflammation; Interleu | 2008 |
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.
Topics: Animals; Antimetabolites; Carbon Monoxide; Enterococcus faecalis; Escherichia coli; Escherichia coli | 2008 |
Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationsh | 2008 |
Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters.
Topics: Adolescent; Adult; Carbon Monoxide; Cohort Studies; Female; Fires; Health Surveys; Humans; Inflammat | 2008 |
Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbon Monoxide; Cytokines; Heme Oxygenase | 2008 |
Carbon monoxide in biological systems: an experimental and clinical study.
Topics: Animals; Blood Donors; Carbon Monoxide; Cytokines; Humans; Inflammation; Swine | 2008 |
Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology.
Topics: Acetaldehyde; Acrolein; Animals; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Carboxyhemoglobin; F | 2008 |
Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.
Topics: Animals; Antimetabolites; Apoptosis; Blood Gas Analysis; Blotting, Northern; Carbon Monoxide; Carbox | 2008 |
Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis.
Topics: Animals; Carbon Monoxide; Inflammation; Lung; Male; Mast Cells; Mice; Mice, Inbred Strains; Pulmonar | 1994 |
A regulatory role for carbon monoxide in mast cell function.
Topics: Animals; Calcium; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Fluorometry; Histamine Release; Inflammat | 1998 |
Exhaled monoxides in asymptomatic atopic subjects.
Topics: Adolescent; Adult; Breath Tests; Bronchoconstrictor Agents; Carbon Monoxide; Female; Humans; Hyperse | 1999 |
Increased carbon monoxide in exhaled air of patients with cystic fibrosis.
Topics: Adrenal Cortex Hormones; Adult; Breath Tests; Carbon Monoxide; Cystic Fibrosis; Female; Humans; Infl | 1999 |
Hemorrhage and resuscitation induce delayed inflammation and pulmonary dysfunction in mice.
Topics: Animals; Blood Pressure; Carbon Monoxide; Female; Inflammation; Lung; Mice; Peak Expiratory Flow Rat | 2000 |
Alterations in exhaled gas profile during allergen-induced asthmatic response.
Topics: Adult; Allergens; Asthma; Breath Tests; Bronchial Provocation Tests; Carbon Dioxide; Carbon Monoxide | 2001 |
Health effects of subchronic exposure to low levels of wood smoke in rats.
Topics: Air Pollutants; Air Pollution; Animals; Body Weight; Carbon Monoxide; Equipment Design; Hydrocarbons | 2002 |
Exhaled markers of inflammation.
Topics: Biomarkers; Breath Tests; Carbon Monoxide; Humans; Hydrocarbons; Inflammation; Leukotrienes; Lung Di | 2001 |