carbon monoxide and Inflammation studies

Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

Excerpt	Relevance	Reference
"This study aimed to assess whether pretreatment with carbon monoxide-releasing molecule-2 (CORM-2) could ameliorate inflammation by regulating differentiation of CD4 + T cells in intestinal mucosa of rats undergoing hemorrhagic shock."	8.12	Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. ( Du, F; Niu, Q; Wang, X; Yang, X, 2022)
"The inhalation of carbon monoxide (CO) gas and the administration of CO-releasing molecules were shown to inhibit the development of intestinal inflammation in a murine colitis model."	8.02	Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. ( Higashimura, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Mizushima, K; Naito, Y; Okayama, T; Takagi, T; Uchiyama, K, 2021)
" The potential of CO-releasing molecules (CORMs), substances that release CO (Carbon monoxide) within animal tissues, for treating paraquat-induced ROS generation and inflammation is investigated here."	8.02	The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis. ( Chang, CY; Cheng, CH; Chiu, HY; Chuu, JJ; Huang, KC; Li, JC; Lin, LS; Wang, SM; Yeh, CH, 2021)
"The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO-1) cascade."	7.96	The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. ( El-Gowilly, SM; El-Mas, MM; Wedn, AM, 2020)
"Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood."	7.85	Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. ( Dahmen, U; Dirsch, O; Dong, W; Guo, E; Hu, J; Jiang, X; Liu, A; Liu, S; Sun, J; Yang, J; Yang, Y, 2017)
"Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated."	7.81	Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015)
" Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear."	7.80	Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014)
"Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae."	7.76	Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. ( Cheng, S; Keaney, JF; Lyass, A; Massaro, JM; O'Connor, GT; Vasan, RS, 2010)
"We assumed that the level of expired-air carbon monoxide may not useful in assessing the severity of inflammation in COPD (Tab."	7.74	Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD? ( Hanta, I; Kocabas, A; Olgunus, O; Satar, S; Seydaoglu, G, 2007)
"To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms."	7.74	[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007)
" We assessed a panel of circulating biomarkers indicative of inflammation and oxidants and measured plasma nicotine and exhaled carbon monoxide (CO) levels before and after the sessions."	5.51	Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness. ( Araujo, JA; Brecht, ML; Cheng, CW; Dobrin, D; Gupta, R; Means, A; Nettle, CO; Rezk-Hanna, M; Tashkin, DP, 2022)
"Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation."	5.48	Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018)
"Resolution of acute inflammation is an active event accompanied by biosynthesis of specialized proresolving mediators (SPM)."	5.39	Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. ( Chiang, N; Choi, AM; Dalli, J; Kibi, M; Mirakaj, V; Serhan, CN; Shinohara, M, 2013)
"Sepsis is characterized by a systemic response to severe infection."	5.35	Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008)
"CO protects against systemic effects of hemorrhagic shock and resuscitation."	5.33	Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005)
"Haem-oxygenase-1 (HO-1) is an enzyme responsible for the degradation of haem that can suppress inflammation, through the production of carbon monoxide (CO)."	4.93	Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance. ( Alvarez-Lobos, MM; Bueno, SM; Carreño, LJ; Espinoza, JA; Kalergis, AM; Mackern-Oberti, JP; Riedel, CA; Riquelme, SA, 2016)
"Carbon monoxide derived from haem oxygenase (HO)-2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO-1 has anti-inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation."	4.89	Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics. ( Bharucha, A; Farrugia, G; Gibbons, SJ; Verhulst, PJ, 2013)
" Beneficial protective effects of HO-1 in inflammation are not only mediated via enzymatic degradation of proinflammatory free heme, but also via production of the anti-inflammatory compounds bilirubin and carbon monoxide."	4.86	Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. ( Blasczyk, R; Eiz-Vesper, B; Immenschuh, S; Paine, A, 2010)
"This study aimed to assess whether pretreatment with carbon monoxide-releasing molecule-2 (CORM-2) could ameliorate inflammation by regulating differentiation of CD4 + T cells in intestinal mucosa of rats undergoing hemorrhagic shock."	4.12	Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. ( Du, F; Niu, Q; Wang, X; Yang, X, 2022)
"The inhalation of carbon monoxide (CO) gas and the administration of CO-releasing molecules were shown to inhibit the development of intestinal inflammation in a murine colitis model."	4.02	Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. ( Higashimura, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Mizushima, K; Naito, Y; Okayama, T; Takagi, T; Uchiyama, K, 2021)
" The potential of CO-releasing molecules (CORMs), substances that release CO (Carbon monoxide) within animal tissues, for treating paraquat-induced ROS generation and inflammation is investigated here."	4.02	The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis. ( Chang, CY; Cheng, CH; Chiu, HY; Chuu, JJ; Huang, KC; Li, JC; Lin, LS; Wang, SM; Yeh, CH, 2021)
"The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO-1) cascade."	3.96	The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. ( El-Gowilly, SM; El-Mas, MM; Wedn, AM, 2020)
" Carbon monoxide (CO) arising from heme degradation, catalyzed particularly by heme oxygenase-1 (HO-1), has been shown to own cytoprotective effects including anti-inflammation and antioxidant."	3.96	Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes. ( Cheng, CY; Chu, PM; Chuang, CC; Huang, HW; Lee, IT; Lin, WN; Vo, TTT, 2020)
"Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood."	3.85	Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. ( Dahmen, U; Dirsch, O; Dong, W; Guo, E; Hu, J; Jiang, X; Liu, A; Liu, S; Sun, J; Yang, J; Yang, Y, 2017)
"Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated."	3.81	Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015)
" Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear."	3.80	Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014)
"Levels of a biological marker of inflammation (carbon monoxide) were assessed by measurement of end-tidal carbon monoxide (ETCO) and lung function by measurement of functional residual capacity (FRC) and compliance (Crs) and resistance (Rrs) of the respiratory system on days 3 and 14 after birth."	3.77	Prediction of bronchopulmonary dysplasia. ( Greenough, A; Kennedy, C; May, C; Patel, S; Peacock, JL; Pollina, E; Rafferty, GF, 2011)
"Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae."	3.76	Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. ( Cheng, S; Keaney, JF; Lyass, A; Massaro, JM; O'Connor, GT; Vasan, RS, 2010)
"To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms."	3.74	[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007)
"We assumed that the level of expired-air carbon monoxide may not useful in assessing the severity of inflammation in COPD (Tab."	3.74	Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD? ( Hanta, I; Kocabas, A; Olgunus, O; Satar, S; Seydaoglu, G, 2007)
"The results demonstrate that inhaled carbon monoxide significantly reduces CPB-induced inflammation via suppression of tumor necrosis factor alpha, and interleukin-1beta expression and elevation of interleukin 10."	3.74	Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs. ( Doenst, T; Geiger, KK; Goebel, U; Loop, T; Mecklenburg, A; Pahl, HL; Roesslein, M; Schlensak, C; Schmidt, R; Schwer, CI; Siepe, M; Stein, P, 2008)
"The source of exhaled carbon monoxide (CO) and the relationship to airway inflammation are not clear."	3.71	Alterations in exhaled gas profile during allergen-induced asthmatic response. ( Dweik, RA; Erzurum, SC; Hammel, J; Khatri, SB; Laskowski, D; McCarthy, K; Ozkan, M, 2001)
"Since chronic obstructive pulmonary disease (COPD) is characterised by inflammation and oxidative stress, low-dose CO could be of therapeutic use."	2.73	Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. ( Bathoorn, E; Boezen, HM; Kerstjens, HA; Koeter, GH; Postma, DS; Slebos, DJ; van der Toorn, M; van Oosterhout, AJ, 2007)
"Carbon monoxide (CO) has long been known as a "silent killer" because of its ability to bind hemoglobin (Hb), leading to reduced oxygen carrying capacity of Hb, which is the main cause of CO poisoning (COP) in humans."	2.72	Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. ( Chang, CP; Chen, RJ; Chen, TH; Chen, YY; Guo, HR; Huang, CC; Lee, YH; Wang, YJ; Yeh, YL, 2021)
"Bilirubin proved to be an efficient free radicals scavenger and modulator of immune responses."	2.66	Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. ( Kapka-Skrzypczak, L; Kurzepa, J; Osiak, W; Wątroba, S, 2020)
"Although many diseases, including cancer, hematological diseases, hypertension, heart failure, inflammation, sepsis, neurodegeneration, and sleep disorders, have been linked to abnormal endogenous CO metabolism and functions, CO administration has therapeutic potential in inflammation, sepsis, lung injury, cardiovascular diseases, transplantation, and cancer."	2.48	Carbon monoxide: an unusual drug. ( Ascenzi, P; di Masi, A; Gullotta, F, 2012)
"Lung inflammation is a pivotal phenomenon in the pathogenesis of cystic fibrosis."	2.44	[Measurement of pulmonary inflammation in cystic fibrosis]. ( Abely, M; Chiron, R; Fayon, M, 2008)
"Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects."	1.72	Delivery of therapeutic carbon monoxide by gas-entrapping materials. ( Aragon, A; Becker, SL; Bi, J; Bosch, DE; Boyce, H; Byrne, JD; Coleman, MC; Cotoia, AT; Csizmadia, E; Feig, VR; Gallo, D; Hayward, A; Ishida, K; Jeck, WR; Jenkins, J; Kezar, KM; Kim, H; Kuosmanen, JLP; Langer, R; Lee, GR; Lee, JS; Longhi, MS; Lopes, A; Otterbein, LE; Shankar, S; Spitz, DR; Steiger, C; Tift, M; Traverso, G; Wainer, J; Wentworth, AJ; Witt, E; Wong, K, 2022)
"Psoriasis is a chronic autoimmune disease mediated by dysregulated immune responses in dendritic cells (DC) and T cells."	1.48	Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment. ( Campbell, NK; Dunne, A; Fitzgerald, HK; Fletcher, JM; Hambly, R; Kirby, B; Malara, A; Sweeney, CM, 2018)
"Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation."	1.48	Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018)
"The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation."	1.43	Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis. ( Agusti, A; Antó, JM; Barreiro, E; Garcia-Aymerich, J; Gómez, F; Marín, A; Monsó, E; Noguera, A; Núñez, B; Sauleda, J, 2016)
"procumbens in carrageenan-induced hyperalgesia in rats."	1.42	Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. ( Aricò, G; Chiechio, S; Di Benedetto, G; Parenti, C; Parenti, R; Scoto, GM, 2015)
"Carbon monoxide (CO) has been recently reported as the main anti-inflammatory mediator of the haem-degrading enzyme haem-oxygenase 1 (HO-1)."	1.42	Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility. ( Bueno, SM; Kalergis, AM; Riquelme, SA, 2015)
"Resolution of acute inflammation is an active event accompanied by biosynthesis of specialized proresolving mediators (SPM)."	1.39	Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. ( Chiang, N; Choi, AM; Dalli, J; Kibi, M; Mirakaj, V; Serhan, CN; Shinohara, M, 2013)
"Carbon monoxide (CO) has anti-inflammatory properties at low concentrations but its effects on reproductive tissues is unclear."	1.39	Does carbon monoxide inhibit proinflammatory cytokine production by fetal membranes? ( Hanna, N; Klimova, NG; Peltier, MR, 2013)
"Ozone was a predictor of C-reactive protein and ICAM-1."	1.38	Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. ( Baccarelli, A; Bind, MA; Schwartz, J; Suh, H; Tarantini, L; Vokonas, P; Zanobetti, A, 2012)
"These chronic metabolic diseases are associated with elevated inflammatory activities."	1.37	The role of carbon monoxide in metabolic disease. ( Chung, HT; Joe, Y; Kim, S; Kim, SK; Min, TS; Ryu, DG; Uddin, JM; Zheng, M, 2011)
"Sepsis is characterized by a systemic response to severe infection."	1.35	Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008)
"CO protects against systemic effects of hemorrhagic shock and resuscitation."	1.33	Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005)
"In a model of acute lung injury in mice, CO blocked expression of Egr-1, a central mediator of inflammation, and decreased tissue damage; inhibition of PPARgamma abrogated both effects."	1.33	Carbon monoxide orchestrates a protective response through PPARgamma. ( Bach, FH; Bilban, M; Chin, BY; d'Avila, JC; Esterbauer, H; Ifedigbo, E; Otterbein, LE; Otterbein, SL; Robson, SC; Usheva, A; Wagner, O, 2006)
"Arterial thrombosis is a critical event in the pathogenesis of lesion development."	1.33	Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. ( Chau, LY; Chen, YH; Chiang, MT; Tsai, HL, 2006)
"Pretreatment with aspirin or bilirubin at low micromolar concentrations protected endothelial cells from hydrogen peroxide-mediated toxicity."	1.32	Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. ( Abate, A; Becker, JC; Dennery, PA; Grosser, N; Oberle, S; Pohle, T; Schröder, H; Seidman, DS; Vreman, HJ, 2003)
"After 30 min of hemorrhagic shock, mice were resuscitated with shed blood to restore mean arterial blood pressure to baseline."	1.31	Hemorrhage and resuscitation induce delayed inflammation and pulmonary dysfunction in mice. ( Claridge, JA; Enelow, RI; Young, JS, 2000)

Research

Studies (167)

Authors

Clinical Trials (15)

Trial Overview

Trial Outcomes

Interleukin 10 (IL-10) Levels

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (2.99)	18.2507
2000's	56 (33.53)	29.6817
2010's	84 (50.30)	24.3611
2020's	22 (13.17)	2.80

Authors	Studies
Gottfried, I	1
Schottlender, N	1
Ashery, U	1
Gasier, HG	1
Suliman, HB	3
Piantadosi, CA	3
Dias-Pedroso, D	1
Ramalho, JS	1
Sardão, VA	1
Jones, JG	1
Romão, CC	2
Oliveira, PJ	1
Vieira, HLA	1
Hsu, CY	1
Vo, TTT	2
Lee, CW	1
Chen, YL	1
Lin, WN	2
Cheng, HC	1
Vo, QC	1
Lee, IT	2
Byrne, JD	1
Gallo, D	4
Boyce, H	1
Becker, SL	1
Kezar, KM	1
Cotoia, AT	1
Feig, VR	1
Lopes, A	1
Csizmadia, E	1
Longhi, MS	1
Lee, JS	1
Kim, H	1
Wentworth, AJ	1
Shankar, S	1
Lee, GR	2
Bi, J	1
Witt, E	1
Ishida, K	1
Hayward, A	1
Kuosmanen, JLP	1
Jenkins, J	1
Wainer, J	1
Aragon, A	1
Wong, K	1
Steiger, C	1
Jeck, WR	1
Bosch, DE	1
Coleman, MC	1
Spitz, DR	1
Tift, M	1
Langer, R	1
Otterbein, LE	11
Traverso, G	1
Sherman, HT	1
Liu, K	1
Kwong, K	1
Chan, ST	1
Li, AC	1
Kong, XJ	1
Cazuza, RA	1
Batallé, G	1
Bai, X	1
Leite-Panissi, CRA	1
Pol, O	2
Zhao, WM	1
Wang, ZJ	1
Shi, R	1
Zhu, YY	1
Zhang, S	1
Wang, RF	1
Wang, DG	1
Niu, Q	3
Du, F	3
Yang, X	6
Wang, X	6
Percival, E	1
Collison, AM	1
da Silva Sena, CR	1
De Queiroz Andrade, E	1
De Gouveia Belinelo, P	1
Gomes, GMC	1
Oldmeadow, C	1
Murphy, VE	1
Gibson, PG	2
Karmaus, W	1
Mattes, J	1
Leake, A	1
Salem, K	1
Madigan, MC	1
Shukla, A	1
Hong, G	1
Zuckerbraun, BS	4
Tzeng, E	1
Ryter, SW	11
Guo, D	1
Hu, H	1
Pan, S	1
Wedn, AM	1
El-Gowilly, SM	1
El-Mas, MM	1
Joe, Y	8
Chen, Y	2
Park, J	2
Kim, HJ	3
Rah, SY	2
Ryu, J	2
Cho, GJ	4
Choi, HS	1
Park, JW	1
Kim, UH	2
Chung, HT	10
Yang, PM	1
Cheng, KC	1
Yuan, SH	1
Wung, BS	1
Cheng, CY	1
Huang, HW	1
Chuang, CC	1
Chu, PM	1
Osiak, W	1
Wątroba, S	1
Kapka-Skrzypczak, L	1
Kurzepa, J	1
Takagi, T	2
Naito, Y	2
Higashimura, Y	1
Uchiyama, K	1
Okayama, T	1
Mizushima, K	2
Katada, K	1
Kamada, K	1
Ishikawa, T	1
Itoh, Y	1
Campbell, NK	2
Fitzgerald, HK	2
Dunne, A	2
Chen, RJ	1
Lee, YH	1
Chen, TH	1
Chen, YY	1
Yeh, YL	1
Chang, CP	1
Huang, CC	1
Guo, HR	1
Wang, YJ	1
Huang, KC	1
Li, JC	1
Wang, SM	1
Cheng, CH	1
Yeh, CH	1
Lin, LS	1
Chiu, HY	1
Chang, CY	1
Chuu, JJ	1
Rezk-Hanna, M	1
Gupta, R	1
Nettle, CO	1
Dobrin, D	1
Cheng, CW	1
Means, A	1
Brecht, ML	1
Tashkin, DP	1
Araujo, JA	1
Shefa, U	1
Yeo, SG	1
Kim, MS	2
Song, IO	1
Jung, J	1
Jeong, NY	1
Huh, Y	1
Wallace, JL	3
Ianaro, A	2
de Nucci, G	1
Schallner, N	1
Lieberum, JL	1
LeBlanc, RH	1
Fuller, PM	1
Hanafy, KA	1
Lee, DW	1
Shin, HY	1
Jeong, JH	1
Han, J	1
Ryu, S	1
Nakahira, K	4
Moon, JS	1
Mangano, K	2
Cavalli, E	1
Mammana, S	1
Basile, MS	1
Caltabiano, R	1
Pesce, A	1
Puleo, S	1
Atanasov, AG	1
Magro, G	1
Nicoletti, F	2
Fagone, P	2
Bauer, B	1
Göderz, AL	1
Braumüller, H	1
Neudörfl, JM	1
Röcken, M	1
Wieder, T	1
Schmalz, HG	2
Wu, J	1
Zhang, R	1
Hu, G	1
Zhu, HH	1
Gao, WQ	1
Xue, J	2
Belcher, JD	3
Chen, C	3
Nguyen, J	3
Abdulla, F	2
Zhang, P	2
Nguyen, H	1
Nguyen, P	1
Killeen, T	1
Miescher, SM	1
Brinkman, N	1
Nath, KA	1
Steer, CJ	1
Vercellotti, GM	3
Taguchi, K	1
Nagao, S	1
Maeda, H	1
Yanagisawa, H	1
Sakai, H	1
Yamasaki, K	1
Wakayama, T	1
Watanabe, H	1
Otagiri, M	1
Maruyama, T	1
Pereira, MLM	1
Marinho, CRF	1
Epiphanio, S	1
Pan, LL	1
Liu, XH	1
Zhu, YZ	1
Malara, A	1
Hambly, R	1
Sweeney, CM	1
Kirby, B	1
Fletcher, JM	1
Minegishi, S	1
Sagami, I	1
Negi, S	1
Kano, K	1
Kitagishi, H	1
Gomperts, E	1
Kiser, ZM	1
Levy, H	1
Kim, SK	2
Park, SU	1
Kim, J	1
Surh, YJ	2
Motterlini, R	10
Nikam, A	1
Manin, S	1
Ollivier, A	1
Wilson, JL	2
Djouadi, S	1
Muchova, L	1
Martens, T	1
Rivard, M	1
Foresti, R	4
Wang, SB	1
Zhang, C	1
Chen, ZX	1
Ye, JJ	1
Peng, SY	1
Rong, L	1
Liu, CJ	1
Zhang, XZ	1
Li, Y	1
Shu, Y	1
Jiao, X	1
Xie, X	1
Zhang, J	2
Tang, B	1
Choi, AM	7
Chiang, N	1
Shinohara, M	1
Dalli, J	1
Mirakaj, V	1
Kibi, M	1
Serhan, CN	1
Stockfelt, L	1
Sallsten, G	1
Almerud, P	1
Basu, S	1
Barregard, L	1
Young, M	1
Burhop, K	1
Tran, P	1
Klimova, NG	1
Hanna, N	1
Peltier, MR	1
Lee, S	1
Lee, SJ	1
Coronata, AA	1
Fredenburgh, LE	1
Chung, SW	2
Perrella, MA	2
Gibbons, SJ	1
Verhulst, PJ	1
Bharucha, A	1
Farrugia, G	1
Negrete, R	1
Hervera, A	1
Leánez, S	1
Qin, W	1
Lv, W	1
Sun, B	2
Kong, JS	1
Jeong, SO	1
Patterson, EK	1
Fraser, DD	1
Capretta, A	1
Potter, RF	1
Cepinskas, G	1
Guarnieri, MJ	1
Diaz, JV	1
Basu, C	1
Diaz, A	1
Pope, D	1
Smith, KR	1
Smith-Sivertsen, T	1
Bruce, N	1
Solomon, C	1
McCracken, J	1
Balmes, JR	1
Babu, D	1
Lefebvre, RA	1
Nikolic, I	1
Vujicic, M	1
Stojanovic, I	1
Stosic-Grujicic, S	1
Saksida, T	1
Stamellou, E	1
Storz, D	1
Botov, S	1
Ntasis, E	1
Wedel, J	1
Sollazzo, S	1
Krämer, BK	1
van Son, W	2
Seelen, M	2
Schmidt, A	1
Hafner, M	1
Yard, BA	2
Riquelme, SA	2
Bueno, SM	2
Kalergis, AM	2
Ahmed, A	1
Ramma, W	1
Chang, M	1
Sharma, V	1
Habtezion, A	1
Simpson, JL	1
Guest, M	1
Boggess, MM	1
Kim, W	1
Kim, HU	1
Lee, HN	1
Kim, SH	1
Kim, C	1
Cha, YN	1
Jang, J	1
Kim, K	1
Suh, YG	1
Jin, HO	1
Lee, JK	1
Qin, S	1
Du, R	1
Yin, S	1
Liu, X	2
Xu, G	1
Cao, W	1
Flannigan, KL	1
Cirino, G	1
Zhao, Z	1
Chen, R	1
Lin, Z	1
Cai, J	1
Yang, Y	2
Yang, D	1
Norback, D	1
Kan, H	1
Sulaieva, O	1
Parenti, C	1
Aricò, G	1
Chiechio, S	1
Di Benedetto, G	1
Parenti, R	1
Scoto, GM	1
Bikov, A	1
Hull, JH	1
Kunos, L	1
Pang, L	1
Zhang, N	1
Dong, N	1
Wang, DW	1
Xu, DH	1
Meng, XW	1
Uddin, MJ	1
Li, CS	1
Zhang, Q	1
Núñez, B	1
Sauleda, J	1
Garcia-Aymerich, J	1
Noguera, A	1
Monsó, E	1
Gómez, F	1
Barreiro, E	1
Marín, A	1
Antó, JM	1
Agusti, A	1
Carreño, LJ	1
Espinoza, JA	1
Mackern-Oberti, JP	1
Alvarez-Lobos, MM	1
Riedel, CA	1
Utiyama, DM	1
Yoshida, CT	1
Goto, DM	1
de Santana Carvalho, T	1
de Paula Santos, U	1
Koczulla, AR	1
Saldiva, PH	1
Nakagawa, NK	1
Qureshi, OS	1
Zeb, A	1
Akram, M	1
Kang, JH	1
Kim, HS	1
Majid, A	1
Han, I	1
Chang, SY	1
Bae, ON	1
Kim, JK	1
Bouillaud, F	1
Almeida, AS	1
Vieira, HL	2
Ouidja, MO	1
Dubois-Randé, JL	1
Sun, J	1
Guo, E	1
Yang, J	1
Liu, S	1
Hu, J	1
Jiang, X	1
Dirsch, O	1
Dahmen, U	1
Dong, W	1
Liu, A	1
Loboda, A	1
Jazwa, A	1
Grochot-Przeczek, A	1
Rutkowski, AJ	1
Cisowski, J	1
Agarwal, A	1
Jozkowicz, A	2
Dulak, J	2
Schmidtko, A	1
Gao, W	1
König, P	1
Heine, S	1
Ruth, P	1
Schlossmann, J	1
Koesling, D	1
Niederberger, E	1
Tegeder, I	1
Friebe, A	1
Geisslinger, G	1
Fayon, M	1
Chiron, R	1
Abely, M	1
Idriss, NK	1
Blann, AD	1
Lip, GY	1
Zhou, HC	1
Ding, WG	1
Cui, XG	1
Pan, P	2
Zhang, B	1
Li, WZ	1
Tomiyama, K	1
Ikeda, A	1
Ueki, S	2
Nakao, A	2
Stolz, DB	1
Koike, Y	1
Afrazi, A	1
Gandhi, C	1
Tokita, D	1
Geller, DA	1
Murase, N	3
Pae, HO	4
Lee, YC	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Cognitive Improvement After cARotid stEnting in HyperBaric Oxygen Therapy Trial (CARE-HBOT)[NCT05980195]		90 participants (Anticipated)	Interventional	2023-08-31	Not yet recruiting
The Effects of Probiotics and Oxytocin Nasal Spray on Social Behaviors of ASD Children- A Pilot Study[NCT03337035]	Phase 1	35 participants (Actual)	Interventional	2018-12-01	Completed
Investigating the Cardiovascular Toxicity of Exposure to Electronic Hookah Smoking[NCT03690427]		19 participants (Actual)	Interventional	2018-12-11	Completed
A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001]	Phase 2	0 participants (Actual)	Interventional	2013-10-31	Withdrawn (stopped due to Sangart ceased operations)
Pravastatin to Prevent Preeclampsia and Reduce Maternal-Neonatal Mortality and Morbidity in High Risk Preeclampsia Patients[NCT03648970]	Phase 2	280 participants (Anticipated)	Interventional	2018-03-01	Recruiting
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nasal Lavage and miRNAs in Blood[NCT02136550]		36 participants (Anticipated)	Interventional	2013-02-28	Active, not recruiting
The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers[NCT04688177]		52 participants (Actual)	Observational	2020-12-03	Completed
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers[NCT02469428]		14 participants (Actual)	Interventional	2013-12-31	Completed
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311]	Phase 4	70 participants (Actual)	Interventional	2006-10-31	Completed
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337]	Phase 4	37 participants (Actual)	Interventional	2006-10-31	Completed
Pulmonary Abnormalities, Diastolic Dysfunction, and World Trade Center Exposure: Implications for Diagnosis and Treatment[NCT01466218]		1,012 participants (Actual)	Observational	2011-11-30	Completed
Measuring Knowledge and Behavior After an Educational Program on Air Pollution as a Health Risk Reduction Strategy[NCT04563052]		40 participants (Actual)	Interventional	2020-01-28	Completed
Modification of Chronic Inflammation by Inhaled Carbon Monoxide in Patients With Stable COPD[NCT00122694]	Phase 2	20 participants	Interventional	2005-01-31	Completed
A Phase Ib Trial of Inhaled Carbon Monoxide for the Treatment of Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)[NCT04870125]	Phase 1	36 participants (Anticipated)	Interventional	2023-12-06	Recruiting
Asthma Inflammation Research[NCT01536522]	Early Phase 1	60 participants (Anticipated)	Interventional	2011-01-31	Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Serum IL-10 (anti-inflammatory biomarker) (NCT03690427)
Timeframe: A change between two points is reported below (e.g., value at post-exposure session minus value at pre-exposure session).

Interleukin 6 (IL-6) Levels

Intervention	pg/mL (Mean)
Electronic Hookah	0.03
Traditional Hookah	-0.01

Plasma IL-6 (inflammatory biomarker). (NCT03690427)
Timeframe: A change between two points is reported below (e.g., value at post-exposure session minus value at pre-exposure session).

Arylesterase Activity

Intervention	pg/mL (Mean)
Electronic Hookah	0.13
Traditional Hookah	0.04

"Arylesterase activity (lipid peroxidation biomarker) was determined by the rate of hydrolysis of phenyl acetate to phenol. Briefly, 4 mL plasma was incubated with 3.5 mM phenyl acetate in 9 mM Tris-HCl buffer (pH, 8.0) containing 0.9 mM CaCl2 at RT. The kinetics of phenol formation were determined by recording the absorbance at 270 nm every 15 s for 2 min.~Unit of Measure: nanomoles of product formed per minute per milliliter of plasma." (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions.

Augmentation Index (AI)

Intervention	units/mL:see Outcome Measure Description (Mean)
	Arylesterase activity before exposure session	Arylesterase activity after exposure session
Electronic Hookah	277.36	295.78
Traditional Hookah	281.38	285.06

AI was used to measure central stiffness. It was calculated as the ratio of augmentation pressure (difference between the second and first systolic peaks of the aortic pressure waveform) and pulse pressure expressed as a percentage. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Carbon Monoxide (CO) Levels

Intervention	percentage of the pulse pressure (Mean)
	AI before exposure session	AI after exposure session
Electronic Hookah	7.97	13.55
Traditional Hookah	7.79	10.66

Exhaled CO levels (smoking or vaping exposure biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Carotid-Femoral Pulse Wave Velocity (Cf-PWV)

Intervention	ppm (Mean)
	CO before exposure session	CO after exposure session
Electronic Hookah	2.58	2.31
Traditional Hookah	3.38	40.19

Using applanation tonometry, cf-PWV was used to measure central arterial stiffness. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Endothelium-independent Vasodilator Function (Control Test for Endothelium-dependent Vasodilator Function)

Intervention	m/sec (Mean)
	cf-PWV before exposure session	cf-PWV after exposure session
Electronic Hookah	8.20	8.94
Traditional Hookah	8.15	8.71

As a control test for the assessment of endothelium-dependent vasodilator function, using ultrasound the brachial artery, endothelium-independent dilatation was assessed by administering sublingual nitroglycerin. This measure was assessed 10 minutes after FMD testing. Ultrasound images were recorded continuously for a total of 10 minutes (NCT03690427)
Timeframe: Pre- and post- sublingual administration of nitroglycerin (0.15 mg), which was administrated before and after e-hookah vaping.

Flow-Mediated Dilation (FMD)

Intervention	percentage of arterial diameter (Mean)
	Dilation before e-hookah vaping	Dilation after e-hookah vaping
Electronic Hookah	27.15	25.17

Using ultrasound, FMD of the brachial artery induced by reactive hyperemia, was used to measure endothelium-dependent vasodilator function. Baseline diameter and velocity were recorded for 45 seconds and resumed 30 seconds before cuff deflation and continuously for 2 minutes after deflation to obtain true peak vasodilatory response. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Flow-Mediated Dilation (FMD)

Intervention	percentage of arterial diameter (Mean)
	FMD before exposure session	FMD after exposure session
Electronic Hookah	6.11	4.79
Traditional Hookah	5.89	7.31

Using ultrasound, FMD of the brachial artery, induced by reactive hyperemia, was used to measure endothelium-dependent vasodilator function after intravenous infusion of antioxidant ascorbic acid. Infusion of antioxidant ascorbic acid was done before the e-hookah vaping session. (NCT03690427)
Timeframe: Effect of FMD with e-hookah vaping examined after pretreatment of intravenous infusion of antioxidant ascorbic acid (administered over 60 minutes at 0.5 mL min-1)

HDL Oxidant Index (HOI)

Intervention	percentage of arterial diameter (Mean)
	FMD before e-hookah vaping	FMD after e-hookah vaping
Electronic Hookah	9.46	8.74

Capacity was determined as the ability of HDL to inhibit LDL-induced oxidation of dihydrodichlorofluorescein into the fluorescent dichlorofluorescein. Capacity was expressed as an HDL oxidative index, determined by the ratio of dichlorofluorescein fluorescence in the presence and absence of HDL. An index of < 1.0 denotes protective antioxidant HDL, whereas an index of > 1.0 indicates pro-oxidant HDL. (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

High-sensitivity C-reactive Protein (Hs-CRP) Levels

Intervention	index (Mean)
	HOI before exposure session	HOI after exposure session
Electronic Hookah	0.57	0.58
Traditional Hookah	0.56	0.52

Plasma hs-CRP (inflammatory biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Nicotine Levels

Intervention	mg/L (Mean)
	hs-CRP before exposure session	hs-CRP after exposure session
Electronic Hookah	0.72	0.76
Traditional Hookah	0.77	0.77

Plasma nicotine levels (smoking or vaping exposure biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Paraoxonase-1 (PON-1) Activity

Intervention	ng/mL (Mean)
	Plasma nicotine before exposure session	Plasma nicotine after exposure session
Electronic Hookah	0.59	5.83
Traditional Hookah	0.82	6.96

"PON-1 activity was determined by the ability of PON-1, associated with HDL, to hydrolyze paraoxon substrate. The hydrolysis of paraoxon (diethyl-p-nitrophenyl phosphate) to p-nitrophenol by PON-1 was determined by incubating 5 mL of plasma with 1.0 mM paraoxon in 100 mM tris-HCl buffer (pH, 8.5).~Unit of Measure: expressed as micromoles of p-nitrophenol formed per minute for every 1 mL plasma." (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Tumor Necrosis Factor-α (TNFα) Concentrations

Intervention	units/mL:see Outcome Measure Description (Mean)
	PON-1 before exposure session	PON-1 after exposure session
Electronic Hookah	1071.24	1151.73
Traditional Hookah	709.32	701.29

Plasma TNFα (inflammatory biomarker) (NCT03690427)
Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Change in Nitric Oxide Formation From Baseline to 3 Months

Intervention	pg/mL (Mean)
	TNFα before exposure session	TNFα after exposure session
Electronic Hookah	0.69	0.76
Traditional Hookah	0.85	0.82

Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)

Change in Nitric Oxide Formation From Baseline to 3 Months.

Intervention	ng/mL (Mean)
Arm 1 of 5 Randomized Treatment Arms	27.6
Arm 2 of 5 Randomized Treatment Arms	27.0
Arm 3 of 5 Randomized Treatment Arms	31.4
Arm 4 of 5 Randomized Treatment Arms	25.7
Arm 5 of 5 Randomized Treatment Arms	28.3

Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)

Article	Year
Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement. Biomolecules, 2021, 10-15, Volume: 11, Issue:10 Topics: Aged; Brain; Carbon Monoxide; Cognition; Humans; Hyperbaric Oxygenation; Inflammation; Mitochondria;	2021
Environmental factors influencing the risk of ANCA-associated vasculitis. Frontiers in immunology, 2022, Volume: 13 Topics: Air Pollutants; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutroph	2022
Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation. Archives of biochemistry and biophysics, 2019, 12-15, Volume: 678 Topics: Animals; Autophagy; Carbon Monoxide; Heme Oxygenase-1; Humans; Inflammation; Mitochondria	2019
Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Bilirubin; Carbon Monoxide; Heme; Humans; Infant, Newborn; Infant, Newborn, Diseases; Inflammation;	2020
Regulation of inflammation by the antioxidant haem oxygenase 1. Nature reviews. Immunology, 2021, Volume: 21, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Monoxide; Dendritic Cells; Enzyme Induction;	2021
Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Archives of toxicology, 2021, Volume: 95, Issue:4 Topics: Animals; Autophagy; Biomarkers; Carbon Monoxide; Carbon Monoxide Poisoning; Cytokines; Exosomes; Hum	2021
Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. BioMed research international, 2017, Volume: 2017 Topics: Alzheimer Disease; Carbon Monoxide; Cardiovascular System; Gasotransmitters; Humans; Hydrogen Sulfid	2017
Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. Digestive diseases and sciences, 2017, Volume: 62, Issue:9 Topics: Animals; Carbon Monoxide; Gasotransmitters; Gastric Mucosa; Gastrointestinal Agents; Gastrointestina	2017
Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome? Frontiers in cellular and infection microbiology, 2018, Volume: 8 Topics: Acute Lung Injury; Animals; Capillary Permeability; Carbon Monoxide; Cytokines; Disease Models, Anim	2018
[Role Ofhydrogen Sulfide on Inflammatory Immune Disorders in Cardiovascular Diseases]. Sheng li ke xue jin zhan [Progress in physiology], 2017, Volume: 48, Issue:1 Topics: Carbon Monoxide; Cardiovascular Diseases; Humans; Hydrogen Sulfide; Immune System Diseases; Inflamma	2017
Carbon monoxide in exhaled breath testing and therapeutics. Journal of breath research, 2013, Volume: 7, Issue:1 Topics: Acute Lung Injury; Anesthesia; Animals; Asthma; Biomarkers; Breath Tests; Carbon Monoxide; Cystic Fi	2013
Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics. Alimentary pharmacology & therapeutics, 2013, Volume: 38, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Gastrointestinal Diseases; Gastrointestinal Trac	2013
Heme oxygenase-1 as a target for drug discovery. Antioxidants & redox signaling, 2014, Apr-10, Volume: 20, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Drug Discovery; Enzyme Induction; Heme Oxygenase	2014
Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. Current pharmaceutical design, 2014, Volume: 20, Issue:35 Topics: Animals; Carbon Monoxide; Cell Survival; Energy Metabolism; Humans; Hydrogen Sulfide; Inflammation;	2014
CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation. British journal of pharmacology, 2015, Volume: 172, Issue:6 Topics: Acute Disease; Animals; Carbon Monoxide; Cytokines; Gastrointestinal Diseases; Gastrointestinal Trac	2015
Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm? British journal of pharmacology, 2015, Volume: 172, Issue:6 Topics: Animals; Carbon Monoxide; Drug Design; Female; Humans; Hydrogen Sulfide; Inflammation; Oxidative Str	2015
Protective role of hemeoxygenase-1 in gastrointestinal diseases. Cellular and molecular life sciences : CMLS, 2015, Volume: 72, Issue:6 Topics: Animals; Biliverdine; Carbon Monoxide; Gastrointestinal Diseases; Gastrointestinal Tract; Gene Expre	2015
Gaseous mediators in resolution of inflammation. Seminars in immunology, 2015, Volume: 27, Issue:3 Topics: Anti-Inflammatory Agents; Apoptosis; Carbon Monoxide; Cytoprotection; Gasotransmitters; Homeostasis;	2015
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. Translational research : the journal of laboratory and clinical medicine, 2016, Volume: 167, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Genetic Therapy; Heme Oxygenase-1; Humans; Infla	2016
Gaseous mediator-based anti-inflammatory drugs. Current opinion in pharmacology, 2015, Volume: 25 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Gasotransmitters; Humans; Hydroge	2015
Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea. Sleep medicine reviews, 2016, Volume: 27 Topics: Biomarkers; Breath Tests; Carbon Monoxide; Humans; Inflammation; Nitric Oxide; Sleep Apnea, Obstruct	2016
Carbon monoxide in the treatment of sepsis. American journal of physiology. Lung cellular and molecular physiology, 2015, Dec-15, Volume: 309, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Heme Oxygenase (Decyclizing); Humans; Inflammati	2015
Mitochondrial Quality Control as a Therapeutic Target. Pharmacological reviews, 2016, Volume: 68, Issue:1 Topics: Carbon Monoxide; Erythropoietin; Estrogens; Free Radical Scavengers; Heme Oxygenase-1; Humans; Hydro	2016
Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance. Immunology, 2016, Volume: 149, Issue:1 Topics: Animals; Antigen Presentation; Carbon Monoxide; Drug Design; Heme Oxygenase-1; Humans; Immune System	2016
Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxidants & redox signaling, 2008, Volume: 10, Issue:10 Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cardiovascular Agents; Cardiovascular Diseases; Ch	2008
[Measurement of pulmonary inflammation in cystic fibrosis]. Revue des maladies respiratoires, 2008, Volume: 25, Issue:6 Topics: Adult; Age Factors; Antioxidants; Biopsy; Breath Tests; Bronchi; Bronchoalveolar Lavage; Carbon Mono	2008
Hemoxygenase-1 in cardiovascular disease. Journal of the American College of Cardiology, 2008, Sep-16, Volume: 52, Issue:12 Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Cardiovascular Diseases; Diabetes Mellitus; Heme	2008
Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy. Recent patents on inflammation & allergy drug discovery, 2008, Volume: 2, Issue:3 Topics: Animals; Carbon Monoxide; Drug Delivery Systems; Heme Oxygenase-1; Humans; Hypersensitivity; Inflamm	2008
Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases! Pharmacology & therapeutics, 2009, Volume: 123, Issue:3 Topics: Animals; Carbon Monoxide; Cardiovascular System; Humans; Hydrogen Sulfide; Inflammation; Nitric Oxid	2009
Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule. Current opinion in pharmacology, 2009, Volume: 9, Issue:4 Topics: Animals; Anti-Infective Agents; Carbon Monoxide; Carbon Monoxide Poisoning; Humans; Inflammation; My	2009
Subtle interplay of endogenous bioactive gases (NO, CO and H(2)S) in inflammation. Archives of pharmacal research, 2009, Volume: 32, Issue:8 Topics: Animals; Carbon Monoxide; Heme Oxygenase-1; Humans; Hydrogen Sulfide; Inflammation; Mitogen-Activate	2009
Mechanisms of cell protection by heme oxygenase-1. Annual review of pharmacology and toxicology, 2010, Volume: 50 Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cytoprotection; Gene Expression Regulation, Enzymo	2010
Carbon monoxide: endogenous mediator, potential diagnostic and therapeutic target. Annals of medicine, 2010, Volume: 42, Issue:1 Topics: Animals; Biomarkers; Carbon Monoxide; Cardiovascular Diseases; Exhalation; Gene Expression; Heme Oxy	2010
Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochemical pharmacology, 2010, Dec-15, Volume: 80, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Bilirubin; Carbon Monoxide; Endothelial Cells; Endothelium, Vascu	2010
The therapeutic potential of carbon monoxide. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:9 Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Homeostasis; Humans; Inflammation; Organ Transpla	2010
The role of brain gaseous transmitters in the regulation of the circulatory system. Current pharmaceutical biotechnology, 2011, Volume: 12, Issue:9 Topics: Animals; Blood Circulation; Brain; Carbon Monoxide; Hydrogen Sulfide; Inflammation; Nitric Oxide	2011
Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer. Immunotherapy, 2011, Volume: 3, Issue:4 Suppl Topics: Animals; Autoimmune Diseases; Carbon Monoxide; Cross-Priming; Cytoprotection; Heme Oxygenase-1; Huma	2011
Therapeutic potential of carbon monoxide in multiple sclerosis. Clinical and experimental immunology, 2012, Volume: 167, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Autoimmunity; Boranes; Carbon Monoxide; Carbonates; Cardiotonic A	2012
Carbon monoxide: an unusual drug. IUBMB life, 2012, Volume: 64, Issue:5 Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Enzyme Induction; Heme Oxygenase-1; Humans; Infla	2012
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation, 2004, Jun-01, Volume: 109, Issue:21 Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi	2004
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation, 2004, Jun-01, Volume: 109, Issue:21 Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi	2004
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation, 2004, Jun-01, Volume: 109, Issue:21 Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi	2004
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation, 2004, Jun-01, Volume: 109, Issue:21 Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Cardiovascular Diseases; Disease Susceptibility; Epi	2004
Heme oxygenase-1 and cardiovascular disease. Histology and histopathology, 2006, Volume: 21, Issue:6 Topics: Animals; Atherosclerosis; Bilirubin; Cadmium Chloride; Carbon Monoxide; Cardiovascular Diseases; Cel	2006
Carbon monoxide: the bad and the good side of the coin, from neuronal death to anti-inflammatory activity. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Carbon Monoxide Poisoning; Cell Death; Heme Oxyg	2006
[Inflammation and oxidative stress]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Sep-10, Volume: 95, Issue:9 Topics: Carbon Monoxide; Cytokines; Free Radicals; Heme Oxygenase-1; Humans; Inflammation; Inflammation Medi	2006
Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities. Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 5 Topics: Carbon Monoxide; Humans; Inflammation; Ischemia; Lipids; Solubility; Vasodilation	2007
Spotlight on microcirculation: an update. Cardiovascular research, 1999, Volume: 42, Issue:3 Topics: Aging; Animals; Carbon Monoxide; Cardiovascular Diseases; Endothelium, Vascular; Endotoxemia; Humans	1999
Gas analysis. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:2 Pt 2 Topics: Adult; Age Factors; Asthma; Biomarkers; Breath Tests; Carbon Monoxide; Child; Cystic Fibrosis; Elect	2000
Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule. Antioxidants & redox signaling, 2002, Volume: 4, Issue:2 Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cell Hypoxia; Disease	2002

Article	Year
Carbon monoxide (CO) correlates with symptom severity, autoimmunity, and responses to probiotics treatment in a cohort of children with autism spectrum disorder (ASD): a post-hoc analysis of a randomized controlled trial. BMC psychiatry, 2022, 08-08, Volume: 22, Issue:1 Topics: Autism Spectrum Disorder; Autoantibodies; Autoimmunity; Biomarkers; Carbon Monoxide; Child; Humans;	2022
The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers. Environmental health : a global access science source, 2023, Dec-05, Volume: 22, Issue:1 Topics: Air Pollutants; Air Pollution; Ammonia; Asthma; Carbon Monoxide; Female; Humans; Infant; Inflammatio	2023
Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness. Chest, 2022, Volume: 161, Issue:1 Topics: Adult; Antioxidants; Aryldialkylphosphatase; C-Reactive Protein; Carbon Monoxide; Carboxylic Ester H	2022
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. PloS one, 2014, Volume: 9, Issue:3 Topics: Adult; Air Pollutants; Carbon Monoxide; Cohort Studies; Cross-Sectional Studies; Female; Fibronectin	2014
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. The European respiratory journal, 2007, Volume: 30, Issue:6 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo	2007
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. The European respiratory journal, 2007, Volume: 30, Issue:6 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo	2007
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. The European respiratory journal, 2007, Volume: 30, Issue:6 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo	2007
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. The European respiratory journal, 2007, Volume: 30, Issue:6 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carbon Monoxide; Eosinophils; Female; Fo	2007

Article	Year
The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle. Exercise and sport sciences reviews, 2022, 01-01, Volume: 50, Issue:1 Topics: Carbon Monoxide; Humans; Inflammation; Muscle, Skeletal; Stress, Physiological	2022
Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells. Molecular neurobiology, 2022, Volume: 59, Issue:2 Topics: Animals; Carbon Monoxide; Inflammation; Lipopolysaccharides; Mice; Microglia; Neuroglobin; Nitric Ox	2022
Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells. Biochemical pharmacology, 2022, Volume: 198 Topics: Angiotensin II; Anti-Inflammatory Agents; Carbon Monoxide; Humans; Inflammation; Interleukin-6; Janu	2022
Delivery of therapeutic carbon monoxide by gas-entrapping materials. Science translational medicine, 2022, 06-29, Volume: 14, Issue:651 Topics: Animals; Carbon Monoxide; Colitis; Gases; Inflammation; Inflammatory Bowel Diseases; Swine	2022
Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice. Brain research bulletin, 2022, 10-01, Volume: 188 Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Carbon Monoxide; Central Nervous System; Chronic	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock. International immunopharmacology, 2022, Volume: 113, Issue:Pt B Topics: Animals; Carbon Monoxide; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Rats; Reperfusi	2022
Systemic vasoprotection by inhaled carbon monoxide is mediated through prolonged alterations in monocyte/macrophage function. Nitric oxide : biology and chemistry, 2020, 01-01, Volume: 94 Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cells	2020
Oligodendrocyte dysfunction and regeneration failure: A novel hypothesis of delayed encephalopathy after carbon monoxide poisoning. Medical hypotheses, 2020, Volume: 136 Topics: Animals; Astrocytes; Axons; Brain; Brain Diseases; Carbon Monoxide; Carbon Monoxide Poisoning; Cell	2020
The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Endotoxemia; Female; Heme Oxygena	2020
Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis. Cell reports, 2020, 01-28, Volume: 30, Issue:4 Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Autophagosomes; Calcium; Carbon Monoxi	2020
Carbon monoxide‑releasing molecules protect against blue light exposure and inflammation in retinal pigment epithelial cells. International journal of molecular medicine, 2020, Volume: 46, Issue:3 Topics: Apoptosis; Carbon Monoxide; Cell Line; Cell Survival; Glutathione Disulfide; Humans; Inflammation; L	2020
Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes. Cytokine, 2020, Volume: 133 Topics: Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Humans; Inflammasomes;	2020
Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats. Nitric oxide : biology and chemistry, 2021, 02-01, Volume: 107 Topics: Administration, Rectal; Animals; Carbon Monoxide; Cells, Cultured; Chemokine CXCL1; Colitis; Colon;	2021
The effects of carbon monoxide releasing molecules on paraquat-induced pulmonary interstitial inflammation and fibrosis. Toxicology, 2021, 05-30, Volume: 456 Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Cell Line; Cell Survival; Dose-Response Relationship,	2021
Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice. Stroke, 2017, Volume: 48, Issue:9 Topics: Animals; Apoptosis; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Carbo	2017
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochemical and biophysical research communications, 2017, 11-18, Volume: 493, Issue:2 Topics: Animals; Carbon Monoxide; Glycolysis; Hyperglycemia; Inflammasomes; Inflammation; Macrophages; Male;	2017
Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis. Journal of cellular physiology, 2018, Volume: 233, Issue:5 Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Concanavalin A; Cytokines; Disease Models, Animal; He	2018
Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents. ChemMedChem, 2017, 12-07, Volume: 12, Issue:23 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Crystallography, X-Ray; Dendritic	2017
Carbon Monoxide Impairs CD11b Journal of immunology (Baltimore, Md. : 1950), 2018, 03-15, Volume: 200, Issue:6 Topics: Animals; Antigens, Ly; Carbon Monoxide; CD11b Antigen; Cell Movement; Chemokine CCL2; Disease Models	2018
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. PloS one, 2018, Volume: 13, Issue:4 Topics: Aldehydes; Anemia, Sickle Cell; Animals; Carbon Monoxide; Cytokines; Disease Models, Animal; Female;	2018
Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. Drug delivery, 2018, Volume: 25, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Biomimetics; Carbon Monoxide; Cell Line; Cytokines; Disease Model	2018
Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment. Scientific reports, 2018, 07-06, Volume: 8, Issue:1 Topics: Abietanes; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cell Differentiation; Cell Prol	2018
Circadian clock disruption by selective removal of endogenous carbon monoxide. Scientific reports, 2018, 08-10, Volume: 8, Issue:1 Topics: Animals; Carbon Monoxide; Circadian Clocks; CLOCK Proteins; Gene Expression Regulation; Inflammation	2018
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia. PloS one, 2018, Volume: 13, Issue:10 Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Antisickling Agents; Carbon Monoxide; Disease Mo	2018
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell death & disease, 2018, 10-17, Volume: 9, Issue:11 Topics: Active Transport, Cell Nucleus; Animals; Antimetabolites; Autophagy; Basic Helix-Loop-Helix Leucine	2018
HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide. Redox biology, 2019, Volume: 20 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Monoxide; Cells, Cultured; Cytokines; Diseas	2019
A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation. ACS nano, 2019, 05-28, Volume: 13, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbon Dioxide; Carbon Monoxide; Cell Line	2019
An H Chemical communications (Cambridge, England), 2019, May-28, Volume: 55, Issue:44 Topics: Carbon Monoxide; Fluorescence; Hydrogen Sulfide; Inflammation; Magnetic Resonance Spectroscopy; Mass	2019
Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. Journal of immunology (Baltimore, Md. : 1950), 2013, Jun-15, Volume: 190, Issue:12 Topics: Animals; Apoptosis; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Humans; Inflammation; Inflam	2013
Short-term chamber exposure to low doses of two kinds of wood smoke does not induce systemic inflammation, coagulation or oxidative stress in healthy humans. Inhalation toxicology, 2013, Volume: 25, Issue:8 Topics: Adult; Air Pollutants; Biomarkers; Blood Coagulation; Carbon Dioxide; Carbon Monoxide; Female; Human	2013
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood, 2013, Oct-10, Volume: 122, Issue:15 Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Disease Models, Animal; Female; Guaiacol; Heme Oxygen	2013
Does carbon monoxide inhibit proinflammatory cytokine production by fetal membranes? Journal of perinatal medicine, 2013, Volume: 41, Issue:6 Topics: Amnion; Anti-Inflammatory Agents; Bacterial Infections; Carbon Monoxide; Chorion; Cytokines; Decidua	2013
Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxidants & redox signaling, 2014, Jan-20, Volume: 20, Issue:3 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carbon Monoxide; Cell Prolif	2014
Treatment with a carbon monoxide-releasing molecule inhibits chronic inflammatory pain in mice: nitric oxide contribution. Psychopharmacology, 2014, Volume: 231, Issue:5 Topics: Animals; Carbon Monoxide; Chronic Pain; Freund's Adjuvant; Heme Oxygenase-1; Hyperalgesia; Inflammat	2014
Effect of carbon monoxide-releasing molecules II-liberated CO on suppressing inflammatory response in sepsis by interfering with nuclear factor kappa B activation. PloS one, 2013, Volume: 8, Issue:10 Topics: Animals; Carbon Monoxide; Cell Adhesion; Human Umbilical Vein Endothelial Cells; Humans; Inflammatio	2013
Carbon monoxide protects against hepatic ischemia/reperfusion injury via ROS-dependent Akt signaling and inhibition of glycogen synthase kinase 3β. Oxidative medicine and cellular longevity, 2013, Volume: 2013 Topics: Administration, Inhalation; Animals; Carbon Monoxide; Cyclic AMP Response Element-Binding Protein; E	2013
Carbon monoxide-releasing molecule 3 inhibits myeloperoxidase (MPO) and protects against MPO-induced vascular endothelial cell activation/dysfunction. Free radical biology & medicine, 2014, Volume: 70 Topics: Carbon Monoxide; Cell Adhesion; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endot	2014
Carbon monoxide-releasing molecule-A1 inhibits Th1/Th17 and stimulates Th2 differentiation in vitro. Scandinavian journal of immunology, 2014, Volume: 80, Issue:2 Topics: Animals; Antibodies; Apoptosis; Boranes; Carbon Monoxide; Carbonates; CD28 Antigens; CD3 Complex; Ce	2014
Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation. Redox biology, 2014, Volume: 2 Topics: Apoptosis; Carbon Monoxide; Coordination Complexes; Cyclohexanones; Gene Expression Regulation; Huma	2014
Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility. Immunology, 2015, Volume: 144, Issue:2 Topics: Animals; Antimetabolites; Carbon Monoxide; Cell Movement; Dendritic Cells; Enzyme Activation; Heme O	2015
Occupational exposures, smoking and airway inflammation in refractory asthma. BMC pulmonary medicine, 2014, Dec-19, Volume: 14 Topics: Aged; Asthma; Asthma, Occupational; Australia; Breath Tests; Carbon Monoxide; Cell Count; Female; Hu	2014
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide. Antioxidants & redox signaling, 2015, Jul-10, Volume: 23, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Monoxide; Cytoskeletal Proteins; Disease Model	2015
Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015, Volume: 64, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carbon Monoxide; Cytokines; Female; Inflamm	2015
Ambient carbon monoxide associated with alleviated respiratory inflammation in healthy young adults. Environmental pollution (Barking, Essex : 1987), 2016, Volume: 208, Issue:Pt A Topics: Adult; Air Pollutants; Biomarkers; Breath Tests; Carbon Monoxide; China; Exhalation; Female; Humans;	2016
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. Molecules (Basel, Switzerland), 2015, Sep-15, Volume: 20, Issue:9 Topics: Analgesics; Animals; Carbon Monoxide; Carrageenan; Harpagophytum; Heme Oxygenase (Decyclizing); Hype	2015
Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses. Inflammation, 2016, Volume: 39, Issue:2 Topics: Animals; Brain Injuries; Carbon Monoxide; Carbon Monoxide Poisoning; Edema; Erythropoietin; Hippocam	2016
Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model. Mediators of inflammation, 2015, Volume: 2015 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Cytokines; Disease Models, Anim	2015
Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis. Archivos de bronconeumologia, 2016, Volume: 52, Issue:7 Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Carbon Dioxide; Carbon Monoxide; Cohort Studi	2016
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation. Clinics (Sao Paulo, Brazil), 2016, Volume: 71, Issue:6 Topics: Adult; Carbon Monoxide; Cell Count; Cotinine; Female; Humans; Inflammation; Interleukin-6; Interleuk	2016
Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 108 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cell Survival; Drug Carriers; Drug Delivery Syst	2016
Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus. Free radical biology & medicine, 2017, Volume: 104 Topics: Adenosine Triphosphate; Animals; Brain; Carbon Monoxide; Cell Line; Glycolysis; Heme Oxygenase-1; In	2017
Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2017, Volume: 23, Issue:4 Topics: Acetylation; Animals; Carbazoles; Carbon Monoxide; HMGB1 Protein; Inflammation; Liver; Liver Transpl	2017
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Aug-20, Volume: 28, Issue:34 Topics: Animals; Behavior, Animal; Carbon Monoxide; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I;	2008
Carbon monoxide inhalation ameliorates conditions of lung grafts from rat brain death donors. Chinese medical journal, 2008, Aug-05, Volume: 121, Issue:15 Topics: Administration, Inhalation; Animals; Apoptosis; Brain Death; Carbon Monoxide; Extracellular Signal-R	2008
Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:5 Topics: Animals; Animals, Genetically Modified; Carbon Monoxide; Flow Cytometry; Genes, Reporter; Green Fluo	2008
Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:3 Topics: Animals; Animals, Newborn; Apoptosis; Bilirubin; Carbon Monoxide; Cells, Cultured; Cerebral Cortex;	2009
Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1. Inflammation, 2009, Volume: 32, Issue:2 Topics: Animals; Arthritis, Experimental; Carbon Monoxide; Cartilage, Articular; Chemokine CCL2; Collagen; F	2009
Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress. Advances in experimental medicine and biology, 2009, Volume: 643 Topics: Animals; Carbon Monoxide; Cytokines; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Inflammation;	2009
Exhaled carbon monoxide as a noninvasive marker of airway neutrophilia after lung transplantation. Transplantation, 2009, May-27, Volume: 87, Issue:10 Topics: Adult; Airway Obstruction; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; C-Reactive Protei	2009
Focus on carbon monoxide: a modulator of neutrophil oxidants and elastase spatial localization? American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:3 Topics: Animals; Carbon Monoxide; Humans; Inflammation; Leukocyte Elastase; Neutrophils; Oxidants	2009
Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats. Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:10 Topics: Acute Lung Injury; Administration, Inhalation; Animals; Apoptosis; Brain Death; Carbon Monoxide; Cas	2010
Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. Circulation, 2010, Oct-12, Volume: 122, Issue:15 Topics: Adult; Carbon Monoxide; Cardiovascular Diseases; Cross-Sectional Studies; Data Collection; Exhalatio	2010
Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation. Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:7 Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Carboxyhemoglobin; Cells, Cultured; Disease Model	2010
[Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2009, Volume: 25, Issue:2 Topics: Animals; Carbon Monoxide; Down-Regulation; Inflammation; Intercellular Adhesion Molecule-1; Intestin	2009
Prediction of bronchopulmonary dysplasia. Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:6 Topics: Biomarkers; Birth Weight; Breath Tests; Bronchopulmonary Dysplasia; Carbon Monoxide; Female; Functio	2011
An increase in exhaled CO concentration in systemic inflammation/sepsis. Journal of breath research, 2010, Volume: 4, Issue:4 Topics: Anesthesia; Biomarkers; Breath Tests; Carbon Monoxide; Critical Illness; Exhalation; Heme Oxygenase-	2010
Inflammatory markers: exhaled nitric oxide and carbon monoxide during the ovarian cycle. Inflammation, 2012, Volume: 35, Issue:2 Topics: Adult; Breath Tests; Carbon Monoxide; Exhalation; Female; Humans; Inflammation; Male; Menstrual Cycl	2012
Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response. Molecular immunology, 2011, Volume: 48, Issue:15-16 Topics: Animals; Blotting, Western; C-Reactive Protein; Carbon Monoxide; Endoplasmic Reticulum; Enzyme-Linke	2011
The role of carbon monoxide in metabolic disease. Annals of the New York Academy of Sciences, 2011, Volume: 1229 Topics: Animals; Apoptosis; Carbon Monoxide; Endoplasmic Reticulum; Heme Oxygenase-1; Humans; Inflammation;	2011
Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death. Transplant international : official journal of the European Society for Organ Transplantation, 2012, Volume: 25, Issue:1 Topics: Adenosine; Allopurinol; Animals; Apoptosis; Carbon Monoxide; Cold Temperature; Cytosol; Death; Gluta	2012
Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages. PloS one, 2011, Volume: 6, Issue:10 Topics: Animals; Carbon Monoxide; Early Growth Response Protein 1; Gene Expression; Inflammation; Ion Channe	2011
Inhibition of VCAM-1 expression in endothelial cells by CORM-3: the role of the ubiquitin-proteasome system, p38, and mitochondrial respiration. Free radical biology & medicine, 2012, Feb-15, Volume: 52, Issue:4 Topics: Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Chemokines; Down-Regulation; Enzyme Acti	2012
Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. Epidemiology (Cambridge, Mass.), 2012, Volume: 23, Issue:2 Topics: Aged; Air Pollution; Biomarkers; Blood Coagulation Disorders; C-Reactive Protein; Carbon; Carbon Mon	2012
Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways. Blood, 2012, Mar-15, Volume: 119, Issue:11 Topics: Animals; Antimetabolites; Antimicrobial Cationic Peptides; Blotting, Western; Carbon Monoxide; Carci	2012
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice. PloS one, 2012, Volume: 7, Issue:6 Topics: Adipose Tissue; Adiposity; Animals; Bilirubin; Blotting, Western; Carbon Monoxide; Cell Movement; Di	2012
Air pollution and autonomic and vascular dysfunction in patients with cardiovascular disease: interactions of systemic inflammation, overweight, and gender. American journal of epidemiology, 2012, Jul-15, Volume: 176, Issue:2 Topics: Aged; Air Pollutants; Air Pollution; Autonomic Nervous System Diseases; Blood Pressure Monitoring, A	2012
Preconditioning triggered by carbon monoxide (CO) provides neuronal protection following perinatal hypoxia-ischemia. PloS one, 2012, Volume: 7, Issue:8 Topics: Animals; Apoptosis; Carbon Monoxide; Carotid Artery, Common; Caspase 3; Cells, Cultured; Hippocampus	2012
Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study. The European respiratory journal, 2013, Volume: 42, Issue:6 Topics: Adult; Age Factors; Aged; Aged, 80 and over; C-Reactive Protein; Carbon Monoxide; Cross-Sectional St	2013
Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats. Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:1 Topics: Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Fe	2013
Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility. Gut, 2003, Volume: 52, Issue:9 Topics: Animals; Bethanechol; Blotting, Northern; Carbon Monoxide; Cyclooxygenase 2; Cytokines; Gastrointest	2003
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo	2003
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo	2003
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo	2003
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo	2003
Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice. Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:4 Topics: Adenoviridae; Animals; Apoptosis; Carbon Monoxide; Enzyme Induction; Genetic Therapy; Heme Oxygenase	2003
Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study. Journal of exposure analysis and environmental epidemiology, 2005, Volume: 15, Issue:4 Topics: Air Pollutants; Carbon Monoxide; Cardiovascular Diseases; Dust; Environmental Monitoring; Factor VII	2005
Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. British journal of pharmacology, 2005, Volume: 145, Issue:6 Topics: Animals; Carbon Monoxide; Cell Line; Cell Survival; Glutathione; Heme Oxygenase (Decyclizing); Heme	2005
Carbon monoxide protects against the development of experimental necrotizing enterocolitis. American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 289, Issue:3 Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Carbon Monoxide; Cell Culture Tech	2005
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. Shock (Augusta, Ga.), 2005, Volume: 23, Issue:6 Topics: Adenosine Triphosphate; Air; Animals; Carbon Monoxide; Cell Death; Cell Survival; Cytokines; Disease	2005
Portal hypertension produces an evolutive hepato-intestinal pro- and anti-inflammatory response in the rat. Cytokine, 2005, Aug-07, Volume: 31, Issue:3 Topics: Animals; Carbon Monoxide; Collateral Circulation; Heme Oxygenase (Decyclizing); Hypertension, Portal	2005
Carbon monoxide orchestrates a protective response through PPARgamma. Immunity, 2006, Volume: 24, Issue:5 Topics: Animals; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Early Growth Response Protein 1	2006
Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. Journal of biomedical science, 2006, Volume: 13, Issue:5 Topics: Animals; Apolipoproteins E; Carbon Monoxide; Carotid Artery, Common; Fibrin; Fibrinogen; Heme Oxygen	2006
ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation. The Journal of biological chemistry, 2006, Oct-27, Volume: 281, Issue:43 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cell Culture Techniques; Cell Line; Enzyme Activ	2006
Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. British journal of pharmacology, 2006, Volume: 149, Issue:4 Topics: Animals; Biliverdine; Carbon Monoxide; Carrageenan; Cell Adhesion; Cell Movement; Deuteroporphyrins;	2006
Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction. Transplantation, 2006, Oct-15, Volume: 82, Issue:7 Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; CD3 Complex; Cytokines; Dendritic Cells; Enzyme-Linked	2006
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. The Journal of biological chemistry, 2007, Jan-19, Volume: 282, Issue:3 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carbon Monoxide; Endothelial Cells; E	2007
Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice. The Journal of surgical research, 2007, May-01, Volume: 139, Issue:1 Topics: Animals; Burns; Carbon Monoxide; Cell Adhesion; Inflammation; Intercellular Adhesion Molecule-1; Lun	2007
A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia. Pharmacological reports : PR, 2006, Volume: 58 Suppl Topics: Animals; Carbon Monoxide; Cell Line; Cell Survival; Enzyme Activation; Guanylate Cyclase; Heme Oxyge	2006
The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells. British journal of pharmacology, 2007, Volume: 150, Issue:8 Topics: Anti-Inflammatory Agents; Caco-2 Cells; Carbon Monoxide; CCAAT-Enhancer-Binding Proteins; Cytokines;	2007
Effect of smoking cessation on markers of inflammation and endothelial cell activation among individuals with high risk for cardiovascular disease. Scandinavian journal of clinical and laboratory investigation, 2007, Volume: 67, Issue:6 Topics: Adult; Biomarkers; C-Reactive Protein; Carbon Monoxide; Cardiovascular Diseases; Endothelial Cells;	2007
Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD? Bratislavske lekarske listy, 2007, Volume: 108, Issue:6 Topics: Aged; Breath Tests; Carbon Monoxide; Female; Forced Expiratory Volume; Humans; Inflammation; Male; M	2007
[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2007, Volume: 23, Issue:3 Topics: Animals; Burns; Carbon Monoxide; Cell Adhesion; Disease Models, Animal; Inflammation; Intercellular	2007
Anti-inflammatory effects of HO-1 activity in vascular endothelial cells, commentary on "Carbon monoxide donors or heme oxygenase (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death". Free radical biology & medicine, 2008, Feb-01, Volume: 44, Issue:3 Topics: Carbon Monoxide; Cell Death; Endothelium, Vascular; Heme Oxygenase-1; Humans; Inflammation; Interleu	2008
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. The Journal of clinical investigation, 2008, Volume: 118, Issue:1 Topics: Animals; Antimetabolites; Carbon Monoxide; Enterococcus faecalis; Escherichia coli; Escherichia coli	2008
Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration. American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationsh	2008
Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters. The European respiratory journal, 2008, Volume: 32, Issue:1 Topics: Adolescent; Adult; Carbon Monoxide; Cohort Studies; Female; Fires; Health Surveys; Humans; Inflammat	2008
Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation. Current pharmaceutical design, 2008, Volume: 14, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbon Monoxide; Cytokines; Heme Oxygenase	2008
Carbon monoxide in biological systems: an experimental and clinical study. Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:5 Topics: Animals; Blood Donors; Carbon Monoxide; Cytokines; Humans; Inflammation; Swine	2008
Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology. Inhalation toxicology, 2008, Volume: 20, Issue:7 Topics: Acetaldehyde; Acrolein; Animals; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Carboxyhemoglobin; F	2008
Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs. Anesthesiology, 2008, Volume: 108, Issue:6 Topics: Animals; Antimetabolites; Apoptosis; Blood Gas Analysis; Blotting, Northern; Carbon Monoxide; Carbox	2008
Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis. Radiation research, 1994, Volume: 140, Issue:3 Topics: Animals; Carbon Monoxide; Inflammation; Lung; Male; Mast Cells; Mice; Mice, Inbred Strains; Pulmonar	1994
A regulatory role for carbon monoxide in mast cell function. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Animals; Calcium; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Fluorometry; Histamine Release; Inflammat	1998
Exhaled monoxides in asymptomatic atopic subjects. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29, Issue:9 Topics: Adolescent; Adult; Breath Tests; Bronchoconstrictor Agents; Carbon Monoxide; Female; Humans; Hyperse	1999
Increased carbon monoxide in exhaled air of patients with cystic fibrosis. Thorax, 1999, Volume: 54, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Breath Tests; Carbon Monoxide; Cystic Fibrosis; Female; Humans; Infl	1999
Hemorrhage and resuscitation induce delayed inflammation and pulmonary dysfunction in mice. The Journal of surgical research, 2000, Volume: 92, Issue:2 Topics: Animals; Blood Pressure; Carbon Monoxide; Female; Inflammation; Lung; Mice; Peak Expiratory Flow Rat	2000
Alterations in exhaled gas profile during allergen-induced asthmatic response. American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 1 Topics: Adult; Allergens; Asthma; Breath Tests; Bronchial Provocation Tests; Carbon Dioxide; Carbon Monoxide	2001
Health effects of subchronic exposure to low levels of wood smoke in rats. Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 65, Issue:1 Topics: Air Pollutants; Air Pollution; Animals; Body Weight; Carbon Monoxide; Equipment Design; Hydrocarbons	2002
Exhaled markers of inflammation. Current opinion in allergy and clinical immunology, 2001, Volume: 1, Issue:3 Topics: Biomarkers; Breath Tests; Carbon Monoxide; Humans; Hydrocarbons; Inflammation; Leukotrienes; Lung Di	2001

carbon monoxide and Inflammation

Research Excerpts

Research

Studies (167)

Authors

Clinical Trials (15)

Trial Overview

Trial Outcomes

Interleukin 10 (IL-10) Levels

Interleukin 6 (IL-6) Levels

Arylesterase Activity

Augmentation Index (AI)

Carbon Monoxide (CO) Levels

Carotid-Femoral Pulse Wave Velocity (Cf-PWV)

Endothelium-independent Vasodilator Function (Control Test for Endothelium-dependent Vasodilator Function)

Flow-Mediated Dilation (FMD)

Flow-Mediated Dilation (FMD)

HDL Oxidant Index (HOI)

High-sensitivity C-reactive Protein (Hs-CRP) Levels

Nicotine Levels

Paraoxonase-1 (PON-1) Activity

Tumor Necrosis Factor-α (TNFα) Concentrations

Change in Nitric Oxide Formation From Baseline to 3 Months

Change in Nitric Oxide Formation From Baseline to 3 Months.

Reviews

Trials

Other Studies

Intervention	ng/mL (Mean)
1 of 5 Randomized Treatment Arms	10.0
2 of 5 Randomized Treatment Arms	11.2
3 of 5 Randomized Treatment Arms	10.0
4 of 5 Randomized Treatment Arms	11.0
5 of 5 Randomized Treatment Arms	9.6