carbon monoxide has been researched along with Disease Models, Animal in 250 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we examined the therapeutic performance of a biomimetic carbon monoxide (CO) delivery system, CO-enriched red blood cells (CO-RBCs), on experimental animal models of an acute kidney injury (AKI) induced by traumatic and nontraumatic rhabdomyolysis, including CS and rhabdomyolysis with massive hemorrhage shock." | 7.96 | Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury. ( Enoki, Y; Fukagawa, M; Ishima, Y; Maeda, H; Maruyama, T; Matsumoto, K; Nagasaki, T; Nishida, K; Ogaki, S; Ooi, K; Otagiri, M; Sekijima, H; Taguchi, K; Watanabe, H; Yanagisawa, H, 2020) |
| "BACKGROUND Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis." | 7.96 | Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture. ( Dong, J; Liu, X; Qin, H; Shao, M; Wang, H; Wu, F; Zhang, H; Zhang, J; Zhang, S; Zhang, W; Zhao, H; Zhao, Y; Zhao, Z, 2020) |
| "The purpose of the present study was to investigate the effect of carbon monoxide (CO) released from CO‑releasing molecule 2 (CORM‑2) on mice with acute pancreatitis (AP)." | 7.91 | Carbon monoxide releasing molecule‑2 (CORM‑2)‑liberated CO ameliorates acute pancreatitis. ( Liu, Y; Qin, W; Sun, B; Wang, X; Xu, X, 2019) |
| "Carbon monoxide (CO) releasing molecule (CORM)-3, a water-soluble CORM, has protective effects against inflammatory and ischemia/reperfusion injury." | 7.91 | Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation. ( Fu, L; Kong, XJ; Li, CC; Li, Y; Qi, MM; Song, PP; Wang, XD; Wang, XP; Zhang, DX; Zhang, LM, 2019) |
| "The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration." | 7.88 | The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. ( Aki, T; Nagano, S; Uemura, K; Unuma, K; Watanabe, R, 2018) |
| "The discovery of carbon monoxide (CO) and hydrogen sulfide (H2S) as pathogenic signaling molecules in airway-related diseases has led to significant insights into the pathophysiologic mechanisms underlying the development of allergic rhinitis (AR)." | 7.81 | Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs. ( Che, N; Ge, R; Yan, Z; Yu, S; Zhang, X, 2015) |
| "Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet." | 7.81 | Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats. ( Chang, R; Huang, J; Huang, Z; Li, Y; Lin, J; Wang, P; Wu, H, 2015) |
| "Treatment with a carbon monoxide-releasing molecule (tricarbonyldichlororuthenium(II) dimer, CORM-2) or a classical heme oxygenase 1 inducer (cobalt protoporphyrin IX, CoPP) has potent anti-inflammatory effects, but the role played by these treatments in the antinociceptive effects of morphine during acute and chronic pain was not evaluated." | 7.79 | Effects of treatment with a carbon monoxide-releasing molecule and a heme oxygenase 1 inducer in the antinociceptive effects of morphine in different models of acute and chronic pain in mice. ( Gou, G; Hervera, A; Leánez, S; Pol, O, 2013) |
| "Clinical reports describe life-threatening cardiac arrhythmias after environmental exposure to carbon monoxide (CO) or accidental CO poisoning." | 7.78 | Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. ( Bernus, O; Boycott, HE; Boyle, JP; Dallas, ML; Duke, A; Elies, J; Milligan, CJ; Peers, C; Reboul, C; Richard, S; Scragg, JL; Steele, DS; Thireau, J; Yang, Z, 2012) |
| " In this study, we assessed the role of CO donor, methylene chloride (MC), on modulation of lung inflammation during sepsis." | 7.76 | Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators. ( Dou, L; He, J; Pan, X; Pang, Q; Xu, W; Zeng, S; Zeng, Y, 2010) |
| "To investigate the anti-atherotic effects of heme-L-lysinate in a rabbit model of atherosclerosis and related machanisms." | 7.76 | [The anti-athetotic effects of heme-L-lysinate in a rabbit model of atherosclerosis]. ( Wang, XB; Wei, WL, 2010) |
| "Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects." | 7.75 | Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. ( Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Motterlini, R; Neviere, R, 2009) |
| "To explore the role of hydrogen sulfide/cystathionine-gamma-lyase (H(2)S/CSE) system in lipopolysaccharide (LPS)- induced acute lung injury (ALI) in rats and the underlying mechanisms." | 7.75 | [Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats]. ( Huang, XL; Ling, YL; Tian, FJ; Wei, P; Zhou, XH, 2009) |
| "The aim of this study is to investigate the effect of heme oxygenase-1 (HO-1)/carbon monoxide (CO) system in pulmonary ischemia-reperfusion injury (PIRI) in rabbits." | 7.75 | Role of heme oxygenase-1/carbon monoxide system in pulmonary ischemia-reperfusion injury. ( Jia, X; Lin, L; Shi, L; Wang, F; Wang, W, 2009) |
| "In previous work we have demonstrated that delivery of low concentrations (250 ppm) of carbon monoxide by means of inhalation to donors, recipients, or both protects transplanted lungs from ischemia-reperfusion injury (improved gas exchange, diminished intragraft and systemic inflammation, and retention of graft vascular endothelial cell ultrastructure)." | 7.74 | Carbon monoxide-saturated preservation solution protects lung grafts from ischemia-reperfusion injury. ( Kohmoto, J; McCurry, KR; Nakao, A; Sugimoto, R; Ueda, H; Wang, Y; Zhan, J, 2008) |
| "We aimed to investigate the toxicity of carbon monoxide (CO) in rats with right ventricle (RV) remodeling induced by hypoxic pulmonary hypertension (PHT)." | 7.74 | Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension. ( Antier, D; Bonnet, P; Eder, V; Gautier, M; Hanton, G; Le Net, JL, 2007) |
| "To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms." | 7.74 | [The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007) |
| "Carbon monoxide with hypoxia and hypoxemic hypoxia both result in similar depression of cardiac function." | 7.74 | Carbon monoxide has direct toxicity on the myocardium distinct from effects of hypoxia in an ex vivo rat heart model. ( Jay, G; Suner, S, 2008) |
| "To investigate the role of carbon monoxide (CO) in the pathogenesis of asthma." | 7.70 | [Evidence of increased endogenous carbon monoxide production in asthma]. ( Jiang, D; Li, H; Shi, Y, 1999) |
| "Pulmonary carbon monoxide (CO) excretion rates (VeCO) were 50% greater, on average, in Bolivian squirrel monkeys (BoSMs) which exhibit a unique fasting hyperbilirubinemia (FH), than in fasted control Brazilian squirrel monkeys (BrSMs)." | 7.68 | Increased carbon monoxide excretion in Bolivian squirrel monkeys with fasting hyperbilirubinemia. ( Cornelius, CE; Rodgers, PA; Tarkington, BK; Vreman, HJ, 1990) |
| " Severe carbon monoxide poisoning with fatal levels of HbCO (greater than 50 percent) was found at the end of smoke inhalation." | 7.68 | The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. ( Li, A; Wang, CZ; Yang, ZC, 1990) |
| "The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension." | 7.67 | Carbon monoxide enhances development of hypertension in Dahl rats. ( Drew, RT; Shiotsuka, RN; Wehner, RW, 1984) |
| "Hemorrhagic shock was induced in adult male Sprague‑Dawley rats under sevoflurane anesthesia by bleeding using a heparinized syringe to maintain a mean arterial pressure of 30±5 mmHg for 60 min." | 5.56 | Exogenous carbon monoxide protects against mitochondrial DNA‑induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation. ( Fu, L; Gui, CX; Kang, LQ; Kong, XJ; Li, Y; Liu, FH; Song, YC; Wang, XD; Wang, XP; Zhang, DX; Zhang, LM; Zheng, WC, 2020) |
| "High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN)." | 5.51 | Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus. ( Chen, YM; Cui, W; Fu, LY; Gao, HL; Kang, KB; Kang, YM; Liang, YF; Liu, KL; Qi, J; Shi, XL; Xin, GR; Yu, XJ; Zhang, DD, 2019) |
| "Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation." | 5.48 | Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018) |
| " Although this is in line with previous systemic CO dosing protocols, GI muscular inflammation and transit retardation by small intestinal manipulation, performed at 1 h after gavage of 20 tablets, was not prevented while the positive control - intravenous nitrite - prevented POI." | 5.48 | Investigation of orally delivered carbon monoxide for postoperative ileus. ( Lefebvre, RA; Meinel, L; Steiger, C; Van Dingenen, J; Zehe, M, 2018) |
| "Preeclampsia is a pregnancy complication which manifests as new-onset hypertension, proteinuria, and a spectrum of other symptoms." | 5.46 | Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension. ( Arany, M; Cockrell, K; Gadepalli, RSV; George, EM; Granger, JP; Rimoldi, JM; Stec, DE, 2017) |
| "Carbon monoxide (CO) is a gaseous neurotransmitter in the central nervous system that stimulates VP neuronal firing activity." | 5.43 | A Functional Coupling Between Carbon Monoxide and Nitric Oxide Contributes to Increased Vasopressin Neuronal Activity in Heart Failure rats. ( Biancardi, VC; Reis, WL; Stern, JE; Zhou, Y, 2016) |
| "To investigate this, we created a hemorrhagic shock model rat, followed by resuscitation with RBC and CO-RBC." | 5.40 | Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats. ( Ishima, Y; Maruyama, T; Ogaki, S; Otagiri, M; Taguchi, K; Watanabe, H, 2014) |
| "Even after successful resuscitation, hemorrhagic shock frequently causes pulmonary inflammation that induces acute lung injury (ALI)." | 5.39 | Inhalation of carbon monoxide following resuscitation ameliorates hemorrhagic shock-induced lung injury. ( Kawanishi, S; Maeda, S; Matsumi, M; Morimatsu, H; Morita, K; Nakao, A; Omori, E; Sato, K; Shimizu, H; Takahashi, T, 2013) |
| "Carbon monoxide (CO) is an endogenous gaseous regulatory molecule, and exogenously delivered CO in low concentrations provides potent cytoprotection." | 5.36 | Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs. ( Castillo-Rama, M; Echeverri, GJ; Ekser, B; Ezzelarab, M; Faleo, G; Murase, N; Nakao, A; Nalesnik, MA; Ozaki, KS; Ross, MA; Stolz, DB; Ueki, S; Yoshida, J, 2010) |
| "CO protects against systemic effects of hemorrhagic shock and resuscitation." | 5.33 | Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005) |
| "Carbon monoxide (CO) has emerged as a potently protective, homeostatic molecule that prevents the development of vascular disorders when administered prophylactically." | 5.33 | Carbon monoxide reverses established pulmonary hypertension. ( Billiar, TR; Chin, BY; Czsimadia, E; Ifedigbo, E; Kanno, S; Otterbein, LE; Rao, J; Shimoda, L; Wegiel, B; Zuckerbraun, BS, 2006) |
| "Oxygen therapy is the specific treatment for CO poisoning, but the treatment of CN toxicity is controversial." | 5.29 | Combined carbon monoxide and cyanide poisoning: a place for treatment. ( Breen, PH; Isserles, SA; Roizen, MF; Taitelman, UZ; Westley, J, 1995) |
| "The amiodarone-treated animals showed a significant reduction in the coefficient of diffusion (kCO) and a significant increase in lung hydroxyproline levels as compared to the control group." | 5.29 | Amiodarone-induced pulmonary fibrosis in Fischer 344 rats. ( Gairola, CG; Lai, YL; Reinhart, PG, 1996) |
| "Pretreatment with pentobarbital Na (30 mg/kg, i." | 5.28 | Carbon monoxide (CO)-induced hypoxia in mice: evaluation as an experimental model of cerebral ischemia for drug screening. ( Hiramatsu, Y; Kato, Y; Koida, M; Muguruma, K; Nakamuta, H; Ogawa, Y; Yasuda, K, 1989) |
| "No myocardial infarctions were observed, and the ECG showed a transitory injury current in only one animal." | 5.26 | Failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (Macaca fascicularis). ( Dhindsa, DS; Hill, J; Malinow, MR; McLaughlin, P; McNulty, WP; Metcalfe, J; Ochsner, AJ, 1976) |
| " In the present study, we examined the therapeutic performance of a biomimetic carbon monoxide (CO) delivery system, CO-enriched red blood cells (CO-RBCs), on experimental animal models of an acute kidney injury (AKI) induced by traumatic and nontraumatic rhabdomyolysis, including CS and rhabdomyolysis with massive hemorrhage shock." | 3.96 | Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury. ( Enoki, Y; Fukagawa, M; Ishima, Y; Maeda, H; Maruyama, T; Matsumoto, K; Nagasaki, T; Nishida, K; Ogaki, S; Ooi, K; Otagiri, M; Sekijima, H; Taguchi, K; Watanabe, H; Yanagisawa, H, 2020) |
| "BACKGROUND Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis." | 3.96 | Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture. ( Dong, J; Liu, X; Qin, H; Shao, M; Wang, H; Wu, F; Zhang, H; Zhang, J; Zhang, S; Zhang, W; Zhao, H; Zhao, Y; Zhao, Z, 2020) |
| " Alternative experimental strategies to reduce oxygen delivery, including breathing carbon monoxide (600 ppm in air) or severe anemia, can reverse neurological disease." | 3.91 | Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. ( Ast, T; Brepoels, K; Carmeliet, P; Galkin, A; Goldberger, O; Ichinose, F; Jain, IH; Marutani, E; Mootha, VK; Schleifer, G; Schoonjans, L; Stepanova, A; Wang, H; Wojtkiewicz, GR; Zapol, WM; Zazzeron, L, 2019) |
| "The present study aimed to investigate the effect of carbon monoxide (CO)‑releasing molecule‑2 (CORM‑2) on pancreatic function in sepsis‑model mice." | 3.91 | Protective effects of carbon monoxide releasing molecule‑2 on pancreatic function in septic mice. ( Liu, Y; Qin, W; Sun, B; Wang, X; Xu, X, 2019) |
| "The purpose of the present study was to investigate the effect of carbon monoxide (CO) released from CO‑releasing molecule 2 (CORM‑2) on mice with acute pancreatitis (AP)." | 3.91 | Carbon monoxide releasing molecule‑2 (CORM‑2)‑liberated CO ameliorates acute pancreatitis. ( Liu, Y; Qin, W; Sun, B; Wang, X; Xu, X, 2019) |
| "Carbon monoxide (CO) releasing molecule (CORM)-3, a water-soluble CORM, has protective effects against inflammatory and ischemia/reperfusion injury." | 3.91 | Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation. ( Fu, L; Kong, XJ; Li, CC; Li, Y; Qi, MM; Song, PP; Wang, XD; Wang, XP; Zhang, DX; Zhang, LM, 2019) |
| "The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration." | 3.88 | The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. ( Aki, T; Nagano, S; Uemura, K; Unuma, K; Watanabe, R, 2018) |
| "The discovery of carbon monoxide (CO) and hydrogen sulfide (H2S) as pathogenic signaling molecules in airway-related diseases has led to significant insights into the pathophysiologic mechanisms underlying the development of allergic rhinitis (AR)." | 3.81 | Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs. ( Che, N; Ge, R; Yan, Z; Yu, S; Zhang, X, 2015) |
| "Hemin can reduce blood pressure and urinary protein in rats with gestational hypertension possibly by up-regulating HO activity, enhancing carbon monoxide production, reducing sFlt-1 and increasing VEGF in the placental tissue." | 3.81 | [Therapeutic effect of hemin on gestational hypertension in rats and the mechanism]. ( Cheng, CX; Li, RZ; Long, ML; Xia, AB, 2015) |
| "Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet." | 3.81 | Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats. ( Chang, R; Huang, J; Huang, Z; Li, Y; Lin, J; Wang, P; Wu, H, 2015) |
| "Inhaled carbon monoxide (CO) appears to have beneficial effects on endotoxemia-induced impairment of hypoxic pulmonary vasoconstriction (HPV)." | 3.81 | Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. ( Busch, CJ; Busch, T; Jahn, N; Kaisers, UX; Koel-Simmelink, MJ; Lamberts, RR; Loer, SA; Oswald, DD; Teunissen, CE; Voelker, MT; Weimann, J, 2015) |
| "Treatment with a carbon monoxide-releasing molecule (tricarbonyldichlororuthenium(II) dimer, CORM-2) or a classical heme oxygenase 1 inducer (cobalt protoporphyrin IX, CoPP) has potent anti-inflammatory effects, but the role played by these treatments in the antinociceptive effects of morphine during acute and chronic pain was not evaluated." | 3.79 | Effects of treatment with a carbon monoxide-releasing molecule and a heme oxygenase 1 inducer in the antinociceptive effects of morphine in different models of acute and chronic pain in mice. ( Gou, G; Hervera, A; Leánez, S; Pol, O, 2013) |
| "Heme oxygenase-1 (HO-1) and its metabolic by-product, carbon monoxide (CO), protect against intestinal inflammation in experimental models of colitis, but little is known about their intestinal immune mechanisms." | 3.79 | Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. ( Borst, LB; Hansen, JJ; Kobayashi, T; Mackey, LC; Maharshak, N; Moeser, AJ; Onyiah, JC; Otterbein, LE; Plevy, SE; Rawls, JF; Russo, SM; Sheikh, SZ; Steinbach, EC, 2013) |
| "CORM-3 and CORM-A1 inhibited thrombosis in vivo, however CORM-A1, which slowly releases carbon monoxide, and displayed a relatively weak hypotensive effect had a more pronounced antithrombotic effect associated with a stronger inhibition of platelet aggregation associated with a decrease in active plasminogen activator inhibitor-1 concentration." | 3.78 | Antithrombotic properties of water-soluble carbon monoxide-releasing molecules. ( Brzoska, T; Buczko, W; Chlopicki, S; Fedorowicz, A; Grochal, E; Kramkowski, K; Leszczynska, A; Mann, B; Mogielnicki, A; Motterlini, R; Urano, T, 2012) |
| "Clinical reports describe life-threatening cardiac arrhythmias after environmental exposure to carbon monoxide (CO) or accidental CO poisoning." | 3.78 | Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. ( Bernus, O; Boycott, HE; Boyle, JP; Dallas, ML; Duke, A; Elies, J; Milligan, CJ; Peers, C; Reboul, C; Richard, S; Scragg, JL; Steele, DS; Thireau, J; Yang, Z, 2012) |
| " In this study, we assessed the role of CO donor, methylene chloride (MC), on modulation of lung inflammation during sepsis." | 3.76 | Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators. ( Dou, L; He, J; Pan, X; Pang, Q; Xu, W; Zeng, S; Zeng, Y, 2010) |
| "To investigate the anti-atherotic effects of heme-L-lysinate in a rabbit model of atherosclerosis and related machanisms." | 3.76 | [The anti-athetotic effects of heme-L-lysinate in a rabbit model of atherosclerosis]. ( Wang, XB; Wei, WL, 2010) |
| "Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects." | 3.75 | Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. ( Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Motterlini, R; Neviere, R, 2009) |
| "To explore the role of hydrogen sulfide/cystathionine-gamma-lyase (H(2)S/CSE) system in lipopolysaccharide (LPS)- induced acute lung injury (ALI) in rats and the underlying mechanisms." | 3.75 | [Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats]. ( Huang, XL; Ling, YL; Tian, FJ; Wei, P; Zhou, XH, 2009) |
| "The aim of this study is to investigate the effect of heme oxygenase-1 (HO-1)/carbon monoxide (CO) system in pulmonary ischemia-reperfusion injury (PIRI) in rabbits." | 3.75 | Role of heme oxygenase-1/carbon monoxide system in pulmonary ischemia-reperfusion injury. ( Jia, X; Lin, L; Shi, L; Wang, F; Wang, W, 2009) |
| "In previous work we have demonstrated that delivery of low concentrations (250 ppm) of carbon monoxide by means of inhalation to donors, recipients, or both protects transplanted lungs from ischemia-reperfusion injury (improved gas exchange, diminished intragraft and systemic inflammation, and retention of graft vascular endothelial cell ultrastructure)." | 3.74 | Carbon monoxide-saturated preservation solution protects lung grafts from ischemia-reperfusion injury. ( Kohmoto, J; McCurry, KR; Nakao, A; Sugimoto, R; Ueda, H; Wang, Y; Zhan, J, 2008) |
| "We aimed to investigate the toxicity of carbon monoxide (CO) in rats with right ventricle (RV) remodeling induced by hypoxic pulmonary hypertension (PHT)." | 3.74 | Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension. ( Antier, D; Bonnet, P; Eder, V; Gautier, M; Hanton, G; Le Net, JL, 2007) |
| " Potential cerebroprotective vascular effects of CORM-A1 (2 mg/kg ip, 30 min before seizures) were tested 2 days after bicuculline-induced epileptic seizures (late postictal period)." | 3.74 | Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury. ( Fedinec, AL; Leffler, CW; Parfenova, H; Tcheranova, D; Zimmermann, A, 2007) |
| "To investigate the inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns and its potential mechanisms." | 3.74 | [The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. ( Chen, X; Chen, ZY; Gediminas, C; Kazuhiro, K; Sun, BW, 2007) |
| "Carbon monoxide with hypoxia and hypoxemic hypoxia both result in similar depression of cardiac function." | 3.74 | Carbon monoxide has direct toxicity on the myocardium distinct from effects of hypoxia in an ex vivo rat heart model. ( Jay, G; Suner, S, 2008) |
| " The use of tin mesoporphyrin (SnMP) has been proposed for interdicting the development of severe hyperbilirubinemia in a variety of conditions." | 3.73 | The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model. ( Contag, CH; DeSandre, GH; Morioka, I; Stevenson, DK; Wong, RJ, 2006) |
| "Recently, heme oxygenase-carbon monoxide (HO-CO) pathway has been reported to be involved in the development of lipopolysaccharide (LPS) fever." | 3.73 | Central heme oxygenase-carbon monoxide pathway participates in the lipopolysaccharide-induced tolerance in rats. ( Branco, LG; Dias, MB; Raffaini, MS, 2006) |
| "To investigate the role of carbon monoxide (CO) in the pathogenesis of asthma." | 3.70 | [Evidence of increased endogenous carbon monoxide production in asthma]. ( Jiang, D; Li, H; Shi, Y, 1999) |
| "Effective alveolar volume, diffusing capacity for carbon monoxide (DCOsb), volume-corrected diffusing capacity (D/VA), static lung compliance (Cst), and lung distensibility were measured in 16 sheep seropositive for maedi-visna virus (MVV) immediately before they were killed." | 3.69 | Pathophysiologic correlations in lymphoid interstitial pneumonia. ( Begara, I; Collie, DD; Luján, L; Warren, PM; Watt, NJ, 1994) |
| "Pulmonary carbon monoxide (CO) excretion rates (VeCO) were 50% greater, on average, in Bolivian squirrel monkeys (BoSMs) which exhibit a unique fasting hyperbilirubinemia (FH), than in fasted control Brazilian squirrel monkeys (BrSMs)." | 3.68 | Increased carbon monoxide excretion in Bolivian squirrel monkeys with fasting hyperbilirubinemia. ( Cornelius, CE; Rodgers, PA; Tarkington, BK; Vreman, HJ, 1990) |
| " Severe carbon monoxide poisoning with fatal levels of HbCO (greater than 50 percent) was found at the end of smoke inhalation." | 3.68 | The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury. ( Li, A; Wang, CZ; Yang, ZC, 1990) |
| "The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension." | 3.67 | Carbon monoxide enhances development of hypertension in Dahl rats. ( Drew, RT; Shiotsuka, RN; Wehner, RW, 1984) |
| "The role of increased heme catabolism in neonatal hyperbilirubinemia was investigated in rhesus (Macaca mulatta) neonates through the measurement of carbon monoxide excretion rates (VECO), blood carboxyhemoglobin content (HbCO), and plasma bilirubin concentrations." | 3.67 | Carbon monoxide excretion as an index of bilirubin production in rhesus monkeys. ( Gale, R; Rodgers, PA; Stevenson, DK; Vreman, HJ, 1989) |
| "Rats prenatally exposed to a low concentration of carbon monoxide which results in carboxyhemoglobin levels equivalent to those maintained by human cigarette smokers, show reduced birth weight and decreased weight gain." | 3.65 | Toxicity of mild prenatal carbon monoxide exposure. ( Annau, Z; Fechter, LD, 1977) |
| "In a porcine model of hemorrhagic shock, the administration of rhIL-11 at the start of resuscitation significantly improved the cardiac output and blood pressure." | 2.71 | Administration of recombinant interleukin-11 improves the hemodynamic functions and decreases third space fluid loss in a porcine model of hemorrhagic shock and resuscitation. ( Alam, HB; Honma, K; Keith, JC; Koles, NL; Olsen, C; Pollack, M; Rhee, P; Rollwagen, FM, 2005) |
| " Although the effectiveness of HbVs, including their physicochemical characteristics and pharmacological effects, has been reported, data on the pharmacokinetic properties of HbVs are limited." | 2.58 | [Safety Evaluation of Cellular-type Artificial Blood Based on Pharmacokinetic Analysis and Its Use in Medical Gas Delivery]. ( Taguchi, K, 2018) |
| "Carbon monoxide (CO) is a product of HO catalysis of heme." | 2.49 | Therapeutic applications of carbon monoxide. ( Haslip, M; Knauert, M; Lee, PJ; Vangala, S, 2013) |
| "Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options." | 1.72 | Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling. ( Deng, Y; Hu, Y; Liu, J; Wang, Q; Wang, Y; Xiong, W; Xu, Y; Yu, J; Zhang, L; Zhou, Q, 2022) |
| "Hemorrhagic shock was induced in adult male Sprague‑Dawley rats under sevoflurane anesthesia by bleeding using a heparinized syringe to maintain a mean arterial pressure of 30±5 mmHg for 60 min." | 1.56 | Exogenous carbon monoxide protects against mitochondrial DNA‑induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation. ( Fu, L; Gui, CX; Kang, LQ; Kong, XJ; Li, Y; Liu, FH; Song, YC; Wang, XD; Wang, XP; Zhang, DX; Zhang, LM; Zheng, WC, 2020) |
| "High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN)." | 1.51 | Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus. ( Chen, YM; Cui, W; Fu, LY; Gao, HL; Kang, KB; Kang, YM; Liang, YF; Liu, KL; Qi, J; Shi, XL; Xin, GR; Yu, XJ; Zhang, DD, 2019) |
| "Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ transplantation." | 1.48 | Carbon monoxide protects the kidney through the central circadian clock and CD39. ( Câmara, NOS; Correa-Costa, M; Csizmadia, E; Gallo, D; Gomperts, E; Hauser, CJ; Ji, X; Lieberum, JL; Otterbein, LE; Robson, SC; Wang, B, 2018) |
| "Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenotype and inhibited neutrophil infiltration in the pancreas, resulting in a significant inflammation." | 1.48 | Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. ( Maeda, H; Maruyama, T; Nagao, S; Otagiri, M; Sakai, H; Taguchi, K; Wakayama, T; Watanabe, H; Yamasaki, K; Yanagisawa, H, 2018) |
| " Although this is in line with previous systemic CO dosing protocols, GI muscular inflammation and transit retardation by small intestinal manipulation, performed at 1 h after gavage of 20 tablets, was not prevented while the positive control - intravenous nitrite - prevented POI." | 1.48 | Investigation of orally delivered carbon monoxide for postoperative ileus. ( Lefebvre, RA; Meinel, L; Steiger, C; Van Dingenen, J; Zehe, M, 2018) |
| "Preeclampsia is a pregnancy complication which manifests as new-onset hypertension, proteinuria, and a spectrum of other symptoms." | 1.46 | Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension. ( Arany, M; Cockrell, K; Gadepalli, RSV; George, EM; Granger, JP; Rimoldi, JM; Stec, DE, 2017) |
| "Carbon monoxide (CO) is a gaseous neurotransmitter in the central nervous system that stimulates VP neuronal firing activity." | 1.43 | A Functional Coupling Between Carbon Monoxide and Nitric Oxide Contributes to Increased Vasopressin Neuronal Activity in Heart Failure rats. ( Biancardi, VC; Reis, WL; Stern, JE; Zhou, Y, 2016) |
| "Hemolytic anemia is a major side effect of ribavirin antiviral treatment for chronic hepatitis C." | 1.43 | Rapid CO breath test screening of drugs for protective effects on ribavirin-induced hemolysis in a rabbit model: a pilot study. ( Cao, P; Du, LT; Huang, JL; Ji, KM; Ji, YQ; Ma, YJ; Wu, CH; Zang, DY; Zhang, HD; Zhu, GL, 2016) |
| "Hydrogen (H2) has anti-inflammation, anti-apoptosis, and anti-oxidative stress effects." | 1.42 | H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. ( Chen, H; Chen, Y; Li, Y; Liu, L; Wang, G; Xie, K; Yu, Y, 2015) |
| "Inhaled carbon monoxide (CO) gas has therapeutic potential for patients with acute respiratory distress syndrome if a safe, evidence-based dosing strategy and a ventilator-compatible CO delivery system can be developed." | 1.42 | Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. ( Baron, RM; Choi, AM; Davies, JD; Fredenburgh, LE; Harris, RS; Hess, DR; Kraft, BD; Piantadosi, CA; Roggli, VL; Stenzler, A; Suliman, HB; Thompson, BT; Welty-Wolf, KE; Winkler, T; Wolf, MA, 2015) |
| "To investigate this, we created a hemorrhagic shock model rat, followed by resuscitation with RBC and CO-RBC." | 1.40 | Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats. ( Ishima, Y; Maruyama, T; Ogaki, S; Otagiri, M; Taguchi, K; Watanabe, H, 2014) |
| "Acute necrotizing pancreatitis was induced by retrograde intraductal injection of sodium taurocholate in rats." | 1.39 | Heme oxygenase 1-generated carbon monoxide and biliverdin attenuate the course of experimental necrotizing pancreatitis. ( Berberat, PO; Bergmann, F; Ceyhan, GO; Fischer, L; Friess, H; Giese, N; Künzli, BM; Mitkus, T; Nuhn, P, 2013) |
| "Carbon monoxide (CO) is an important effector-signaling molecule involved in various pathophysiological processes." | 1.39 | Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN/LPS-induced acute liver injury in mice. ( Li, F; Liu, Y; Wen, T; Wen, Z, 2013) |
| "Carbon monoxide (CO) treatment improves pathogenic outcome of autoimmune diseases by promoting tolerance." | 1.39 | Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes. ( Anegon, I; Bach, JM; Blancou, P; Piaggio, E; Pogu, S; Rémy, S; Rigaud, K; Simon, T; Tardif, V, 2013) |
| "Even after successful resuscitation, hemorrhagic shock frequently causes pulmonary inflammation that induces acute lung injury (ALI)." | 1.39 | Inhalation of carbon monoxide following resuscitation ameliorates hemorrhagic shock-induced lung injury. ( Kawanishi, S; Maeda, S; Matsumi, M; Morimatsu, H; Morita, K; Nakao, A; Omori, E; Sato, K; Shimizu, H; Takahashi, T, 2013) |
| "Carbon monoxide (250 ppm) was given for 1 hour after termination of CPB." | 1.37 | Postconditioning of the lungs with inhaled carbon monoxide after cardiopulmonary bypass in pigs. ( Brehm, K; Goebel, U; Loop, T; Priebe, HJ; Schibilsky, D; Schlensak, C; Schwer, CI; Siepe, M, 2011) |
| "Carbon monoxide (CO) is an endogenous gaseous regulatory molecule, and exogenously delivered CO in low concentrations provides potent cytoprotection." | 1.36 | Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs. ( Castillo-Rama, M; Echeverri, GJ; Ekser, B; Ezzelarab, M; Faleo, G; Murase, N; Nakao, A; Nalesnik, MA; Ozaki, KS; Ross, MA; Stolz, DB; Ueki, S; Yoshida, J, 2010) |
| "Up to 60% of the mice showed dyspnea, airway obstruction and hypoxemia and died between days 7 and 12 post-infection." | 1.36 | VEGF promotes malaria-associated acute lung injury in mice. ( Ataíde, R; Campos, MG; Carapau, D; Costa-Silva, A; Dias, S; Epiphanio, S; Félix, N; Marinho, CR; Monteiro, CA; Mota, MM; Pamplona, A; Pena, AC, 2010) |
| " These studies highlight the complexity of interspecies variation of dose-response relationships of CO to COHb levels and to the anti-inflammatory functions of CO." | 1.36 | Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation. ( Channell, MM; Choi, AM; McDonald, JD; Mitchell, LA; Royer, CM; Ryter, SW, 2010) |
| "Carbon monoxide (CO) is a biologically active molecule produced in the body by the stress-inducible enzyme, heme oxygenase." | 1.35 | Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis. ( Alber, S; Choi, AM; Kaminski, N; Lin, L; Morse, D; Watkins, S; Zheng, L; Zhou, Z, 2009) |
| "Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of morbidity and mortality in the intensive care unit, but despite continuing research few effective therapies have been identified." | 1.33 | Effects of inhaled carbon monoxide on acute lung injury in mice. ( Choudhury, S; Falusi, B; Ghosh, S; Goddard, ME; Marczin, N; Takata, M; Wilson, MR; Yamamoto, H, 2005) |
| "CO protects against systemic effects of hemorrhagic shock and resuscitation." | 1.33 | Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. ( Billiar, TR; Gallo, D; Ifedigbo, E; Liu, F; McCloskey, CA; Otterbein, LE; Zuckerbraun, BS, 2005) |
| "In a model of acute lung injury in mice, CO blocked expression of Egr-1, a central mediator of inflammation, and decreased tissue damage; inhibition of PPARgamma abrogated both effects." | 1.33 | Carbon monoxide orchestrates a protective response through PPARgamma. ( Bach, FH; Bilban, M; Chin, BY; d'Avila, JC; Esterbauer, H; Ifedigbo, E; Otterbein, LE; Otterbein, SL; Robson, SC; Usheva, A; Wagner, O, 2006) |
| "Carbon monoxide (CO) has emerged as a potently protective, homeostatic molecule that prevents the development of vascular disorders when administered prophylactically." | 1.33 | Carbon monoxide reverses established pulmonary hypertension. ( Billiar, TR; Chin, BY; Czsimadia, E; Ifedigbo, E; Kanno, S; Otterbein, LE; Rao, J; Shimoda, L; Wegiel, B; Zuckerbraun, BS, 2006) |
| "Sepsis was induced in male Sprague-Dawley rats by cecal ligation and puncture (CLP)." | 1.32 | Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats. ( Iwasashi, H; Kondo, N; Matsuno, S; Oikawa, M; Suzuki, M; Unno, M; Utiyama, T, 2003) |
| "Carbon monoxide (CO) has long been considered a toxic substance." | 1.32 | [The effects of inhaled carbon monoxide on lung injury in rats caused by lipopolysaccharide]. ( Fujimoto, J; Kudoh, I; Miyazaki, H; Ohta, M; Tazawa, T; Yamada, H, 2003) |
| "Human emphysema is a progressive, destructive lung disease that produces morphologic and functional heterogeneity throughout its course." | 1.32 | Physiologic responses of sheep to two different methods of papain exposure. ( Henderson, AC; Hoffman, A; Ingenito, E; Tsai, L, 2003) |
| "In models of smoke inhalation injury and carbon monoxide poisoning blood carboxy-hemoglobin (COHb) levels decrease faster than predicted by the generally recognized half-life of COHb." | 1.31 | Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide. ( Goodwin, CW; Ikeuchi, H; Mason, AD; Pruitt, BA; Shimazu, T; Sugimoto, H, 2000) |
| "A diffuse nonspecific interstitial pneumonitis was present in lungs of immunodeficient mice, and flow cytometry indicated that both lymphocytes and macrophages were activated." | 1.30 | Pulmonary mechanical and immunologic dysfunction in a murine model of AIDS. ( Cohen, DA; Gillespie, MN; Hartsfield, CL; Lai, YL; Lipke, D, 1997) |
| "Oxygen therapy is the specific treatment for CO poisoning, but the treatment of CN toxicity is controversial." | 1.29 | Combined carbon monoxide and cyanide poisoning: a place for treatment. ( Breen, PH; Isserles, SA; Roizen, MF; Taitelman, UZ; Westley, J, 1995) |
| " Loss of organic anion accumulation and release into the incubation medium of tubular enzymes, mainly from the soluble fraction, are the toxic effects of the solvent." | 1.29 | In-vitro mechanisms of 1,2-dichloropropane nephrotoxicity using the renal cortical slice model. ( Maso, S; Meneghetti, P; Trevisan, A; Troso, O, 1993) |
| "The amiodarone-treated animals showed a significant reduction in the coefficient of diffusion (kCO) and a significant increase in lung hydroxyproline levels as compared to the control group." | 1.29 | Amiodarone-induced pulmonary fibrosis in Fischer 344 rats. ( Gairola, CG; Lai, YL; Reinhart, PG, 1996) |
| "Pretreatment with pentobarbital Na (30 mg/kg, i." | 1.28 | Carbon monoxide (CO)-induced hypoxia in mice: evaluation as an experimental model of cerebral ischemia for drug screening. ( Hiramatsu, Y; Kato, Y; Koida, M; Muguruma, K; Nakamuta, H; Ogawa, Y; Yasuda, K, 1989) |
| "No myocardial infarctions were observed, and the ECG showed a transitory injury current in only one animal." | 1.26 | Failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (Macaca fascicularis). ( Dhindsa, DS; Hill, J; Malinow, MR; McLaughlin, P; McNulty, WP; Metcalfe, J; Ochsner, AJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (7.60) | 18.7374 |
| 1990's | 22 (8.80) | 18.2507 |
| 2000's | 78 (31.20) | 29.6817 |
| 2010's | 116 (46.40) | 24.3611 |
| 2020's | 15 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Watabe, Y | 1 |
| Taguchi, K | 6 |
| Sakai, H | 4 |
| Enoki, Y | 2 |
| Maruyama, T | 5 |
| Otagiri, M | 5 |
| Kohno, M | 1 |
| Matsumoto, K | 2 |
| Hu, Y | 1 |
| Wang, Q | 1 |
| Yu, J | 2 |
| Zhou, Q | 1 |
| Deng, Y | 1 |
| Liu, J | 1 |
| Zhang, L | 1 |
| Xu, Y | 1 |
| Xiong, W | 1 |
| Wang, Y | 2 |
| Xu, Q | 1 |
| Rose, JJ | 1 |
| Chen, X | 3 |
| Wang, L | 1 |
| DeMartino, AW | 1 |
| Dent, MR | 1 |
| Tiwari, S | 1 |
| Bocian, K | 1 |
| Huang, XN | 1 |
| Tong, Q | 1 |
| McTiernan, CF | 1 |
| Guo, L | 1 |
| Alipour, E | 1 |
| Jones, TC | 1 |
| Ucer, KB | 1 |
| Kim-Shapiro, DB | 1 |
| Tejero, J | 1 |
| Gladwin, MT | 1 |
| Xue, Y | 1 |
| Zhang, D | 1 |
| Wei, Y | 1 |
| Guo, C | 1 |
| Song, B | 1 |
| Cui, Y | 1 |
| Zhang, C | 1 |
| Xu, D | 1 |
| Zhang, S | 2 |
| Fang, J | 3 |
| Jain, IH | 1 |
| Zazzeron, L | 2 |
| Goldberger, O | 1 |
| Marutani, E | 1 |
| Wojtkiewicz, GR | 1 |
| Ast, T | 1 |
| Wang, H | 5 |
| Schleifer, G | 1 |
| Stepanova, A | 1 |
| Brepoels, K | 1 |
| Schoonjans, L | 1 |
| Carmeliet, P | 1 |
| Galkin, A | 1 |
| Ichinose, F | 1 |
| Zapol, WM | 2 |
| Mootha, VK | 1 |
| Yang, X | 1 |
| de Caestecker, M | 1 |
| Otterbein, LE | 15 |
| Wang, B | 2 |
| Ogaki, S | 2 |
| Nagasaki, T | 1 |
| Yanagisawa, H | 2 |
| Nishida, K | 1 |
| Maeda, H | 5 |
| Sekijima, H | 1 |
| Ooi, K | 1 |
| Ishima, Y | 2 |
| Watanabe, H | 4 |
| Fukagawa, M | 1 |
| Joe, Y | 6 |
| Chen, Y | 6 |
| Park, J | 3 |
| Kim, HJ | 4 |
| Rah, SY | 1 |
| Ryu, J | 2 |
| Cho, GJ | 3 |
| Choi, HS | 1 |
| Ryter, SW | 11 |
| Park, JW | 2 |
| Kim, UH | 3 |
| Chung, HT | 6 |
| Fu, L | 2 |
| Zhang, DX | 2 |
| Zhang, LM | 2 |
| Song, YC | 1 |
| Liu, FH | 1 |
| Li, Y | 6 |
| Wang, XP | 2 |
| Zheng, WC | 1 |
| Wang, XD | 2 |
| Gui, CX | 1 |
| Kong, XJ | 2 |
| Kang, LQ | 1 |
| Kim, J | 2 |
| Song, HC | 1 |
| Zheng, M | 2 |
| Surh, YJ | 3 |
| Zhao, H | 1 |
| Qin, H | 2 |
| Zhang, J | 1 |
| Dong, J | 1 |
| Zhang, H | 1 |
| Liu, X | 1 |
| Zhao, Z | 1 |
| Zhao, Y | 1 |
| Shao, M | 1 |
| Wu, F | 1 |
| Zhang, W | 2 |
| Baugh, JJ | 1 |
| White, BA | 1 |
| Biddinger, PD | 1 |
| Raja, AS | 1 |
| Wittbold, KA | 1 |
| Sonis, JD | 1 |
| Yun, BJ | 1 |
| Sakihama, H | 1 |
| Lee, GR | 1 |
| Chin, BY | 3 |
| Csizmadia, E | 3 |
| Gallo, D | 6 |
| Qi, Y | 1 |
| Gagliani, N | 1 |
| Bach, FH | 3 |
| Jiang, M | 1 |
| Deng, Z | 1 |
| Zeng, S | 2 |
| Hao, J | 1 |
| Iqbal, J | 1 |
| Chamberlain, J | 1 |
| Alfaidi, M | 1 |
| Hughes, M | 1 |
| Alizadeh, T | 1 |
| Casbolt, H | 1 |
| Evans, P | 1 |
| Mann, B | 2 |
| Motterlini, R | 9 |
| Francis, S | 1 |
| Gunn, J | 1 |
| Gomperts, E | 3 |
| Belcher, JD | 4 |
| Coates, TD | 1 |
| Wood, J | 1 |
| Skolnick, BE | 1 |
| Levy, H | 2 |
| Vercellotti, GM | 4 |
| George, EM | 1 |
| Cockrell, K | 1 |
| Arany, M | 1 |
| Stec, DE | 2 |
| Rimoldi, JM | 1 |
| Gadepalli, RSV | 1 |
| Granger, JP | 1 |
| Kim, SK | 2 |
| Park, SU | 1 |
| Ha, Y | 1 |
| Lee, Y | 1 |
| Suh, M | 1 |
| Crocker, GH | 1 |
| Kwon, J | 1 |
| Kass, PH | 1 |
| Jones, JH | 1 |
| Mangano, K | 1 |
| Cavalli, E | 1 |
| Mammana, S | 1 |
| Basile, MS | 1 |
| Caltabiano, R | 1 |
| Pesce, A | 1 |
| Puleo, S | 1 |
| Atanasov, AG | 1 |
| Magro, G | 1 |
| Nicoletti, F | 1 |
| Fagone, P | 1 |
| Unuma, K | 1 |
| Aki, T | 1 |
| Nagano, S | 1 |
| Watanabe, R | 1 |
| Uemura, K | 1 |
| Lin, S | 1 |
| Juriasingani, S | 1 |
| Sener, A | 1 |
| Wu, J | 4 |
| Zhang, R | 1 |
| Hu, G | 1 |
| Zhu, HH | 1 |
| Gao, WQ | 1 |
| Xue, J | 1 |
| Correa-Costa, M | 1 |
| Lieberum, JL | 1 |
| Hauser, CJ | 1 |
| Ji, X | 1 |
| Câmara, NOS | 1 |
| Robson, SC | 2 |
| Chen, C | 3 |
| Nguyen, J | 3 |
| Abdulla, F | 2 |
| Zhang, P | 1 |
| Nguyen, H | 1 |
| Nguyen, P | 1 |
| Killeen, T | 1 |
| Miescher, SM | 1 |
| Brinkman, N | 1 |
| Nath, KA | 1 |
| Steer, CJ | 1 |
| Nagao, S | 2 |
| Yamasaki, K | 2 |
| Wakayama, T | 2 |
| Pereira, MLM | 1 |
| Marinho, CRF | 1 |
| Epiphanio, S | 3 |
| Serban, KA | 1 |
| Petrache, I | 1 |
| Van Dingenen, J | 1 |
| Steiger, C | 3 |
| Zehe, M | 1 |
| Meinel, L | 3 |
| Lefebvre, RA | 1 |
| Kiser, ZM | 1 |
| Nikam, A | 1 |
| Manin, S | 1 |
| Ollivier, A | 1 |
| Wilson, JL | 1 |
| Djouadi, S | 1 |
| Muchova, L | 2 |
| Martens, T | 1 |
| Rivard, M | 1 |
| Foresti, R | 2 |
| McRae, KE | 1 |
| Peterson, N | 1 |
| Dickson, MA | 1 |
| Smith, GN | 2 |
| Zheng, G | 1 |
| Zhan, Y | 1 |
| Luo, Z | 1 |
| Zheng, F | 1 |
| Zhou, Y | 2 |
| Wu, Y | 2 |
| Wang, S | 1 |
| Xiang, G | 1 |
| Xu, C | 1 |
| Xu, H | 1 |
| Tian, N | 1 |
| Zhang, X | 2 |
| Wollborn, J | 1 |
| Ruetten, E | 1 |
| Benk, C | 1 |
| Kari, FA | 1 |
| Wunder, C | 3 |
| Buerkle, H | 2 |
| Schick, MA | 2 |
| Goebel, U | 4 |
| Liu, Y | 3 |
| Wang, X | 6 |
| Xu, X | 2 |
| Qin, W | 2 |
| Sun, B | 2 |
| Slawik, A | 1 |
| Platt, N | 1 |
| Urban, JT | 1 |
| Yang, P | 1 |
| Huang, Y | 1 |
| Lu, S | 1 |
| Xu, F | 1 |
| Zhang, DD | 1 |
| Liang, YF | 1 |
| Qi, J | 1 |
| Kang, KB | 1 |
| Yu, XJ | 1 |
| Gao, HL | 1 |
| Liu, KL | 1 |
| Chen, YM | 1 |
| Shi, XL | 1 |
| Xin, GR | 1 |
| Fu, LY | 1 |
| Kang, YM | 1 |
| Cui, W | 1 |
| Qi, MM | 1 |
| Li, CC | 1 |
| Song, PP | 1 |
| Hervera, A | 1 |
| Gou, G | 1 |
| Leánez, S | 1 |
| Pol, O | 1 |
| Collino, M | 1 |
| Pini, A | 1 |
| Mugelli, N | 1 |
| Mastroianni, R | 1 |
| Bani, D | 1 |
| Fantozzi, R | 1 |
| Papucci, L | 1 |
| Fazi, M | 1 |
| Masini, E | 2 |
| Wang, QM | 1 |
| Yin, XY | 1 |
| Duan, ZJ | 1 |
| Guo, SB | 1 |
| Sun, XY | 1 |
| Hosick, PA | 1 |
| AlAmodi, AA | 1 |
| Storm, MV | 1 |
| Gousset, MU | 1 |
| Pruett, BE | 1 |
| Gray, W | 1 |
| Stout, J | 1 |
| Mackern-Oberti, JP | 3 |
| Llanos, C | 3 |
| Carreño, LJ | 1 |
| Riquelme, SA | 2 |
| Jacobelli, SH | 1 |
| Anegon, I | 3 |
| Kalergis, AM | 3 |
| Choi, AM | 11 |
| Turedi, S | 1 |
| Yilmaz, SE | 1 |
| Mentese, A | 1 |
| Turkmen, S | 1 |
| Karaca, Y | 1 |
| Sen, O | 1 |
| Yulug, E | 1 |
| Gunduz, A | 1 |
| Young, M | 1 |
| Burhop, K | 1 |
| Tran, P | 1 |
| Barbour, AG | 1 |
| Hirsch, CM | 1 |
| Ghalyanchi Langeroudi, A | 1 |
| Meinardi, S | 1 |
| Lewis, ER | 1 |
| Estabragh, AS | 1 |
| Blake, DR | 1 |
| Yu, JK | 1 |
| Chang, KC | 2 |
| Kim, HK | 1 |
| Han, J | 1 |
| Giles, LV | 1 |
| Koehle, MS | 1 |
| Zacharia, VM | 1 |
| Manzanillo, PS | 1 |
| Nair, VR | 1 |
| Marciano, DK | 1 |
| Kinch, LN | 1 |
| Grishin, NV | 1 |
| Cox, JS | 1 |
| Shiloh, MU | 1 |
| Abid, S | 1 |
| Houssaïni, A | 1 |
| Mouraret, N | 1 |
| Marcos, E | 1 |
| Amsellem, V | 1 |
| Wan, F | 1 |
| Dubois-Randé, JL | 1 |
| Derumeaux, G | 1 |
| Boczkowski, J | 1 |
| Adnot, S | 1 |
| Linzke, N | 1 |
| Schumacher, A | 1 |
| Woidacki, K | 1 |
| Croy, BA | 1 |
| Zenclussen, AC | 1 |
| Madigan, M | 1 |
| Entabi, F | 1 |
| Zuckerbraun, B | 1 |
| Loughran, P | 1 |
| Tzeng, E | 1 |
| Li, CM | 2 |
| Li, L | 2 |
| Bai, JY | 1 |
| Sun, Y | 2 |
| Huang, S | 1 |
| Wang, GL | 2 |
| Li, M | 1 |
| Wegiel, B | 2 |
| Knauert, M | 1 |
| Vangala, S | 1 |
| Haslip, M | 1 |
| Lee, PJ | 1 |
| Chan, EC | 1 |
| Dusting, GJ | 1 |
| Liu, GS | 1 |
| Jiang, F | 1 |
| Schmidt, CB | 1 |
| Simon, T | 2 |
| Jara, E | 1 |
| Riedel, CA | 1 |
| Bueno, SM | 1 |
| Yin, H | 1 |
| Liao, L | 1 |
| Su, Q | 1 |
| Venditti, CC | 1 |
| Casselman, R | 1 |
| Young, I | 1 |
| Karumanchi, SA | 1 |
| Shen, WC | 1 |
| Qin, WT | 1 |
| Qiu, XF | 1 |
| Sun, BW | 4 |
| Yu, S | 1 |
| Yan, Z | 1 |
| Che, N | 1 |
| Ge, R | 1 |
| Meyer, G | 3 |
| André, L | 3 |
| Kleindienst, A | 1 |
| Singh, F | 1 |
| Tanguy, S | 2 |
| Richard, S | 4 |
| Obert, P | 3 |
| Boucher, F | 2 |
| Jover, B | 1 |
| Cazorla, O | 3 |
| Reboul, C | 4 |
| Guan, L | 2 |
| Zhang, YL | 1 |
| Li, ZY | 1 |
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| Dufour, F | 1 |
| Nalecz, KA | 1 |
| Nalecz, MJ | 1 |
| Nehlig, A | 1 |
| Jiang, D | 1 |
| Shi, Y | 1 |
| Li, H | 2 |
| Pan, J | 1 |
| Snider, GL | 1 |
| Celli, BR | 1 |
| Goldstein, RH | 1 |
| O'Brien, JJ | 1 |
| Lucey, EC | 1 |
| Turner, DM | 1 |
| Lee, PN | 1 |
| Roe, FJ | 1 |
| Gough, KJ | 1 |
| Clarkson, TB | 1 |
| Lehner, ND | 1 |
| Bullock, BC | 1 |
| Lofland, HB | 1 |
| Wagner, WD | 1 |
| Malinow, MR | 1 |
| McLaughlin, P | 1 |
| Dhindsa, DS | 1 |
| Metcalfe, J | 1 |
| Ochsner, AJ | 1 |
| Hill, J | 1 |
| McNulty, WP | 1 |
| Annau, Z | 1 |
| Reznik, G | 1 |
| Reznik-Schüller, H | 1 |
| Schostek, H | 1 |
| Deppe, K | 1 |
| Mohr, U | 1 |
| Ishimaru, H | 1 |
| Katoh, A | 1 |
| Suzuki, H | 1 |
| Fukuta, T | 1 |
| Muguruma, K | 2 |
| Nakamuta, H | 2 |
| Tsuji, M | 1 |
| Yanagita, K | 1 |
| Koida, M | 2 |
| Manno, K | 1 |
| Narama, I | 1 |
| Ogawa, Y | 2 |
| Hiramatsu, Y | 2 |
| Vasil'ev, GA | 1 |
| Khaĭtsev, NV | 1 |
| Doolittle, DJ | 1 |
| Rahn, CA | 1 |
| Lee, CK | 1 |
| Rodgers, PA | 2 |
| Cornelius, CE | 1 |
| Vreman, HJ | 2 |
| Tarkington, BK | 1 |
| Gering, SA | 1 |
| Folts, JD | 1 |
| Wang, CZ | 1 |
| Li, A | 1 |
| Yang, ZC | 1 |
| Yasuda, K | 1 |
| Kato, Y | 1 |
| Gale, R | 1 |
| Young, JS | 1 |
| Upchurch, MB | 1 |
| Kaufman, MJ | 1 |
| Demaria Pesce, VH | 1 |
| Stupfel, M | 1 |
| Gourlet, V | 1 |
| Lemercerre, C | 1 |
| Bloch, WN | 1 |
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| Busch, KA | 1 |
| Orthoefer, JG | 1 |
| Stara, JF | 1 |
| Pushpakom, R | 1 |
| Hogg, JC | 1 |
| Woolcock, AJ | 1 |
| Angus, AE | 1 |
| Macklem, PT | 1 |
| Thurlbeck, WM | 1 |
| Bertranou, E | 1 |
| Bourassa, MG | 1 |
| Grondin, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001] | Phase 2 | 0 participants (Actual) | Interventional | 2013-10-31 | Withdrawn (stopped due to Sangart ceased operations) | ||
| A Phase Ib Trial of Inhaled Carbon Monoxide for the Treatment of Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)[NCT04870125] | Phase 1 | 36 participants (Anticipated) | Interventional | 2023-12-06 | Recruiting | ||
| A Phase II Trial of Inhaled Carbon Monoxide for the Treatment of Acute Respiratory Distress Syndrome (ARDS)[NCT03799874] | Phase 2 | 32 participants (Anticipated) | Interventional | 2019-07-01 | Active, not recruiting | ||
| An Open-Label, Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-Aminolevulinic Acid Phosphate and Sodium Ferrous Citrate (5-ALA-Phosphate + SFC) in Subjects With SARS-CoV-2 Infection (COVID-19)[NCT04542850] | 15 participants (Actual) | Interventional | 2020-11-15 | Completed | |||
| The Effect of Blood Carboxyhemoglobin Levels on Total Antioxidant (Tas), Total Oxidant(Tos), Hypoxia Inducible Factor-1a (hif1a) During Low-flow and Normal-flow Anesthesia[NCT05661045] | 130 participants (Anticipated) | Observational | 2023-01-02 | Not yet recruiting | |||
| Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension Compared to Male Cirrhosis Patients Without Hypotension[NCT05051293] | 0 participants (Actual) | Observational | 2021-08-22 | Withdrawn (stopped due to Study will be changed from prospective to retrospective) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 reviews available for carbon monoxide and Disease Models, Animal
| Article | Year |
|---|---|
Carbon monoxide: An emerging therapy for acute kidney injury.
Topics: Acute Kidney Injury; Animals; Carbon Monoxide; Clinical Trials as Topic; Disease Models, Animal; Dru | 2020 |
To solve our new emergency care crisis, let's start with the old one.
Topics: Animals; Argon; Carbon Monoxide; Disease Models, Animal; Emergency Medical Services; Helium; Humans; | 2020 |
The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Clinical Trials as Topic; Disease Models, Animal; Hem | 2017 |
Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction?
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Fibrosis; Gasotransmitters; Humans; Hydrogen Sulfi | 2018 |
Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?
Topics: Acute Lung Injury; Animals; Capillary Permeability; Carbon Monoxide; Cytokines; Disease Models, Anim | 2018 |
[Safety Evaluation of Cellular-type Artificial Blood Based on Pharmacokinetic Analysis and Its Use in Medical Gas Delivery].
Topics: Acute Disease; Animals; Blood Substitutes; Carbon Monoxide; Disease Models, Animal; Drug Carriers; D | 2018 |
Gaseous therapeutics in acute lung injury.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; Hum | 2011 |
The health effects of exercising in air pollution.
Topics: Air Pollution; Animals; Carbon Monoxide; Cardiovascular Diseases; Cognition Disorders; Disease Model | 2014 |
Therapeutic applications of carbon monoxide.
Topics: Animals; Carbon Monoxide; Clinical Trials as Topic; Disease Models, Animal; Humans | 2013 |
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Disease Models, Animal; Heme Oxygenase-1; Humans; | 2014 |
Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Carbon Monoxide; Cell Survival; Disease Models, Animal; Gene Targeting | 2014 |
Localized delivery of carbon monoxide.
Topics: Administration, Cutaneous; Administration, Inhalation; Administration, Oral; Animals; Biliverdine; C | 2017 |
A central role for free heme in the pathogenesis of severe malaria: the missing link?
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heme; Heme Oxygenase-1; Hemoglobins; Humans; Malar | 2008 |
Regulation of vulnerable plaque development by the heme oxygenase/carbon monoxide system.
Topics: Animals; Carbon Monoxide; Coronary Artery Disease; Disease Models, Animal; Heme Oxygenase (Decyclizi | 2010 |
The role of heme oxygenase and carbon monoxide in inflammatory bowel disease.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Enzyme Activation; Gastrointestinal Tract; Heme Ox | 2010 |
The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule.
Topics: Adrenomedullin; Animals; Biological Factors; Blood Pressure; Cannabinoid Receptor Modulators; Carbon | 2006 |
Therapeutic applications of carbon monoxide in lung disease.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Apoptosis; Asthma; Bleomycin; Carbon | 2006 |
[Hypertension in obese Zucker rat].
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hypertension; Insulin Resistance; Leptin; Natriure | 2006 |
The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure.
Topics: Animals; Carbon Monoxide; Critical Illness; Disease Models, Animal; Gene Expression Regulation, Enzy | 2008 |
Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule.
Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cell Hypoxia; Disease | 2002 |
Atherosclerosis in new world monkeys.
Topics: Age Factors; Alouatta; Animals; Aorta; Arteriosclerosis; Callitrichinae; Carbon Monoxide; Cholelithi | 1976 |
1 trial available for carbon monoxide and Disease Models, Animal
| Article | Year |
|---|---|
Administration of recombinant interleukin-11 improves the hemodynamic functions and decreases third space fluid loss in a porcine model of hemorrhagic shock and resuscitation.
Topics: Animals; Blood Pressure; Carbon Monoxide; Cardiac Output; Disease Models, Animal; Hemodynamics; Inte | 2005 |
228 other studies available for carbon monoxide and Disease Models, Animal
| Article | Year |
|---|---|
Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A.
Topics: Animals; Blood Substitutes; Bronchiolitis Obliterans; Carbon Monoxide; Disease Models, Animal; Disea | 2022 |
Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
Topics: Animals; beta Catenin; Bleomycin; Carbon Monoxide; Cell Differentiation; Cell Movement; Cell Prolife | 2022 |
Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning.
Topics: Animals; Carbon Monoxide; Carbon Monoxide Poisoning; Disease Models, Animal; Hemoglobins; Horses; Hu | 2022 |
Polymeric nano-micelle of carbon monoxide donor SMA/CORM2 ameliorates acetaminophen-induced liver injury via suppressing HMGB1/TLR4 signaling pathway.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Chemical and Drug Induced Liver I | 2023 |
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Topics: Anemia; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Carbon Monoxide; Disease Model | 2019 |
Carbon Monoxide Rescues the Developmental Lethality of Experimental Rat Models of Rhabdomyolysis-Induced Acute Kidney Injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Carbon Monoxide; Crush Syndrome; Disease Models, Animal; Dr | 2020 |
Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Autophagosomes; Calcium; Carbon Monoxi | 2020 |
Exogenous carbon monoxide protects against mitochondrial DNA‑induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; DNA, Mitochondrial; Hippocampus; Male; Pyroptosis; | 2020 |
CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway.
Topics: Aging; Animals; Caenorhabditis elegans; Carbon Monoxide; Cellular Senescence; Disease Models, Animal | 2020 |
Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.
Topics: Animals; Carbon Monoxide; Caspase 1; Cecum; Cytokines; Disease Models, Animal; Intestinal Mucosa; In | 2020 |
Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Bone Marrow Transplantation; Carbon Monoxide; Cell Diffe | 2021 |
Low Dose Soft X-Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti-Tumor Immunoresponse.
Topics: Animals; Cancer Vaccines; Carbon Monoxide; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal | 2021 |
Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model.
Topics: Animals; Apoptosis; Biomarkers; Boranes; Carbon Monoxide; Carbonates; Cardiovascular Agents; Caspase | 2021 |
Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carbon Monoxide; Disease Models, Animal; Female; G | 2017 |
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Topics: Activating Transcription Factor 4; AMP-Activated Protein Kinases; Animals; Autophagy; Carbon Monoxid | 2017 |
Insertable NO/CO Microsensors Recording Gaseous Vasomodulators Reflecting Differential Neuronal Activation Level with Respect to Seizure Focus.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Brain; Brain Chemistry; Carbon Monoxide; Dendrites; | 2017 |
Ventilatory response to carbon monoxide during exercise in hypoxia and hypercapnia.
Topics: Adult; Animals; Anthracenes; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Exercise Te | 2017 |
Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis.
Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Concanavalin A; Cytokines; Disease Models, Animal; He | 2018 |
The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide.
Topics: Actins; Animals; Carbon Monoxide; Cardiac Myosins; Cardiotonic Agents; Cell Line; Cytokines; Disease | 2018 |
Carbon Monoxide Impairs CD11b
Topics: Animals; Antigens, Ly; Carbon Monoxide; CD11b Antigen; Cell Movement; Chemokine CCL2; Disease Models | 2018 |
Carbon monoxide protects the kidney through the central circadian clock and CD39.
Topics: Animals; Antigens, CD; Apyrase; Carbon Monoxide; Disease Models, Animal; Humans; Kidney; Kidney Dise | 2018 |
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.
Topics: Aldehydes; Anemia, Sickle Cell; Animals; Carbon Monoxide; Cytokines; Disease Models, Animal; Female; | 2018 |
Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity.
Topics: Animals; Anti-Inflammatory Agents; Biomimetics; Carbon Monoxide; Cell Line; Cytokines; Disease Model | 2018 |
Mouse Models of COPD.
Topics: Animals; Biomarkers; Carbon Monoxide; Disease Models, Animal; Electronic Nicotine Delivery Systems; | 2018 |
Investigation of orally delivered carbon monoxide for postoperative ileus.
Topics: Administration, Oral; Animals; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Drug Deli | 2018 |
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Antisickling Agents; Carbon Monoxide; Disease Mo | 2018 |
HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Monoxide; Cells, Cultured; Cytokines; Diseas | 2019 |
CORM-A1 treatment leads to increased carbon monoxide in pregnant mice.
Topics: Animals; Blood Gas Analysis; Boranes; Carbon Monoxide; Carbonates; Disease Models, Animal; Female; H | 2018 |
Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation.
Topics: Animals; Biomarkers; Carbon Monoxide; Cell Count; Cell Death; Disease Models, Animal; Female; Inflam | 2019 |
Carbon monoxide improves haemodynamics during extracorporeal resuscitation in pigs.
Topics: Alarmins; Animals; Carbon Monoxide; Cardiopulmonary Resuscitation; Disease Models, Animal; Extracorp | 2020 |
Protective effects of carbon monoxide releasing molecule‑2 on pancreatic function in septic mice.
Topics: Animals; Biomarkers; Carbon Monoxide; Cytokines; Disease Models, Animal; Inflammation Mediators; Mic | 2019 |
User-oriented independent analysis of the toxic load model's ability to predict the effects of time-varying toxic inhalation exposures.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hydrogen Cyanide; Inhalation Exposure; Models, Bio | 2019 |
Novel Role of Carbon Monoxide in Improving Neurological Outcome After Cardiac Arrest in Aged Rats: Involvement of Inducing Mitochondrial Autophagy.
Topics: Animals; Autophagy; Brain; Brain Ischemia; Carbon Monoxide; Disease Models, Animal; Heart Arrest; Ma | 2019 |
Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Carbon | 2019 |
Carbon monoxide releasing molecule‑2 (CORM‑2)‑liberated CO ameliorates acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Carbon Monoxide; Ceruletide; Cytokines; Disease Models, Animal; In | 2019 |
Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Disease Models, Animal; Humans; Mitochondria; Neurons; Neuropr | 2019 |
Effects of treatment with a carbon monoxide-releasing molecule and a heme oxygenase 1 inducer in the antinociceptive effects of morphine in different models of acute and chronic pain in mice.
Topics: Acute Pain; Analgesics; Animals; Behavior, Animal; Carbon Monoxide; Chronic Pain; Disease Models, An | 2013 |
Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure.
Topics: Animals; Apoptosis; Biomarkers; Carbon Monoxide; Disease Models, Animal; DNA Damage; Enzyme Activati | 2013 |
Role of the heme oxygenase/carbon monoxide pathway in the pathogenesis and prevention of hepatic encephalopathy.
Topics: Animals; Aquaporin 4; Brain; Carbon Monoxide; Diet; Disease Models, Animal; Gene Expression Regulati | 2013 |
Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet.
Topics: Adipocytes; Animals; Blood Glucose; Blotting, Western; Boranes; Carbon Monoxide; Carbonates; Diet, H | 2014 |
Carbon monoxide exposure improves immune function in lupus-prone mice.
Topics: Animals; Autoimmunity; Carbon Monoxide; CD11b Antigen; Disease Models, Animal; Enzyme Induction; Fem | 2013 |
The diagnostic value of serum ischemia-modified albumin levels in experimentally induced carbon monoxide poisoning and their correlation with poisoning severity.
Topics: Animals; Biomarkers; Biopsy, Needle; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; | 2013 |
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Disease Models, Animal; Female; Guaiacol; Heme Oxygen | 2013 |
Elevated carbon monoxide in the exhaled breath of mice during a systemic bacterial infection.
Topics: Animals; Borrelia; Borrelia Infections; Breath Tests; Carbon Dioxide; Carbon Monoxide; Chromatograph | 2013 |
Resveratrol induces hepatic mitochondrial biogenesis through the sequential activation of nitric oxide and carbon monoxide production.
Topics: Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Hep G2 Cells; Humans; Injections, In | 2014 |
cor, a novel carbon monoxide resistance gene, is essential for Mycobacterium tuberculosis pathogenesis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Carbon Monoxide; Disease Models, Animal; DNA Transpo | 2013 |
P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Arterial Pressure; Carbon Monoxide; Cell Proliferation; | 2014 |
Carbon monoxide promotes proliferation of uterine natural killer cells and remodeling of spiral arteries in pregnant hypertensive heme oxygenase-1 mutant mice.
Topics: Administration, Inhalation; Animals; Arteries; Blotting, Western; Carbon Monoxide; Disease Models, A | 2014 |
Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions.
Topics: Administration, Inhalation; Angioplasty, Balloon; Animals; Apoptosis; Autophagy; Carbon Monoxide; Ca | 2015 |
Upregulation of heat shock protein 32 with hemin alleviates acute heat-induced hepatic injury in mice.
Topics: Animals; Apoptosis; Carbon Monoxide; Disease Models, Animal; Heat-Shock Proteins; Heme Oxygenase (De | 2014 |
Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration.
Topics: Acetylation; Administration, Inhalation; Animals; Carbon Monoxide; Cell Movement; Chromatin Assembly | 2014 |
Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dapsone; Disease Models, Animal; Erythrocy | 2014 |
Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carbon Monoxide; Cell Line, Tumor; C | 2014 |
Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFlt-1 preeclampsia-like mouse model.
Topics: Adenoviridae; Animals; Carbon Monoxide; Disease Models, Animal; Female; Hypertension; Mice; Mothers; | 2014 |
Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.
Topics: Animals; Biomarkers; Carbon Monoxide; Cytokines; Disease Models, Animal; Dose-Response Relationship, | 2014 |
Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs.
Topics: Air Pollutants; Animals; Antimetabolites; Blotting, Western; Carbon Monoxide; Cystathionine gamma-Ly | 2015 |
Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion.
Topics: Air Pollutants; Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Enzyme Inhibitors; E | 2015 |
Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties.
Topics: Alkenes; Animals; Brain Injuries; Carbon Monoxide; Carbon Monoxide Poisoning; Disease Models, Animal | 2015 |
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Monoxide; Cytoskeletal Proteins; Disease Model | 2015 |
H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain.
Topics: Animals; Carbon Monoxide; Cytokines; Disease Models, Animal; Heme Oxygenase-1; Hydrogen; Male; Neura | 2015 |
[Therapeutic effect of hemin on gestational hypertension in rats and the mechanism].
Topics: Animals; Blood Pressure; Carbon Monoxide; Disease Models, Animal; Female; Heme Oxygenase (Decyclizin | 2015 |
Carbon Monoxide Releasing Molecule Accelerates Reendothelialization after Carotid Artery Balloon Injury in Rat.
Topics: Animals; Carbon Monoxide; Carotid Artery Injuries; Carotid Artery, Common; Cell Adhesion; Disease Mo | 2015 |
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1.
Topics: Acute-Phase Reaction; Animals; Apoptosis; Carbon Monoxide; Disease Models, Animal; Enzyme Inhibitors | 2015 |
Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus.
Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoantibodies; Carbon Monoxide; Cytokin | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blood Urea Nitrogen; Carbon Monoxide; Carrier Proteins; Cre | 2015 |
Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice.
Topics: Administration, Inhalation; Animals; Arterial Pressure; Carbon Monoxide; Cytokines; Disease Models, | 2015 |
Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Cytokines; Disease Models, Anim | 2015 |
A Functional Coupling Between Carbon Monoxide and Nitric Oxide Contributes to Increased Vasopressin Neuronal Activity in Heart Failure rats.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heart Failure; Heme Oxygenase-1; Inhibitory Postsy | 2016 |
Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Colitis; Dextran Sulfate; Disease Models, Animal | 2016 |
Heme Oxygenase-1 and Carbon Monoxide Promote Burkholderia pseudomallei Infection.
Topics: Animals; Blotting, Western; Burkholderia pseudomallei; Carbon Monoxide; Cytokines; Disease Models, A | 2016 |
Changes in expression and production of heme oxygenase-1 in rats with acute liver injury induced by lipopolysaccharide.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Monoxide; Caspase 3; Chemical and | 2016 |
Carbon monoxide treatment reduces microglial activation in the ischemic rat retina.
Topics: Animals; Blood Cells; Calcium-Binding Proteins; Carbon Monoxide; Disease Models, Animal; Female; Flu | 2016 |
Rapid CO breath test screening of drugs for protective effects on ribavirin-induced hemolysis in a rabbit model: a pilot study.
Topics: Anemia, Hemolytic; Animals; Antiviral Agents; Breath Tests; Carbon Monoxide; Disease Models, Animal; | 2016 |
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.
Topics: Animals; Biliverdine; Carbon Monoxide; Dengue; Dengue Virus; Disease Models, Animal; Diterpenes; Enz | 2016 |
Heme Oxygenase-1/Carbon Monoxide-regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-induced Acute Lung Injury in Rats and in Lipopolysaccharide-activated Macrophages.
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Disease Models, Animal; Endotoxins; Heme Oxygenase-1; L | 2016 |
Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain; Brain Injuries, Traumatic; Bromodeoxyuridine; C | 2016 |
Effects of multiple brief exposures to trauma-associated cues on traumatized resilient and vulnerable rats.
Topics: Animals; Anxiety; Arousal; Avoidance Learning; Carbon Monoxide; Conditioning, Psychological; Cues; D | 2016 |
Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats.
Topics: Androstanols; Animals; Blood Pressure; Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; | 2017 |
Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease.
Topics: Animals; Capillaries; Carbon Monoxide; Cell Line; Disease Models, Animal; Gene Expression Regulation | 2017 |
Carbon monoxide pollution aggravates ischemic heart failure through oxidative stress pathway.
Topics: Air Pollutants; Animals; Calcium; Carbon Monoxide; Coronary Vessels; Disease Models, Animal; Electro | 2017 |
Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Enzyme-Linked Immuno | 2017 |
CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Drug Stability; Erythrocytes; Hemoglobins; Male; M | 2008 |
HIF-1alpha subunit and vasoactive HIF-1-dependent genes are involved in carbon monoxide-induced cerebral hypoxic stress response.
Topics: Adrenomedullin; Animals; Blotting, Western; Brain; Carbon Monoxide; Cerebrovascular Circulation; Dis | 2008 |
Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blood Pressure; Carbon Monoxide; Cyclic GMP; Disease Models | 2008 |
Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Erythrocytes; Hemoglobins; Liver; Lung; Male; Rats | 2009 |
Carbon monoxide-saturated preservation solution protects lung grafts from ischemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Carbon Monoxide; Disease Models, Animal; Graft Rejection; Graft Survi | 2008 |
Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis.
Topics: Actins; Administration, Inhalation; Animals; Bleomycin; Bone Development; Carbon Monoxide; Cell Deat | 2009 |
Low-dose inhaled carbon monoxide attenuates the remote intestinal inflammatory response elicited by hindlimb ischemia-reperfusion.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cytokines; Disease M | 2009 |
Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: preliminary investigation.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hair Cells, Auditory; Hearing Loss, Noise-Induced; | 2008 |
[Interaction between endogenous cystathionine synthase/hydrogen sulfide and heme oxygenase-1/carbon monoxide systems during myocardial ischemic-reperfusion: experiment with rats].
Topics: Animals; Carbon Monoxide; Cystathionine beta-Synthase; Disease Models, Animal; Heme Oxygenase (Decyc | 2008 |
Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Male; Membr | 2009 |
[Effect of thyroid hormone on the contents of NOS and CO in the penile corpus cavernosum of rats].
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hyperthyroidism; Hypothyroidism; Male; Nitric Oxid | 2009 |
Carbon monoxide prevents ventilator-induced lung injury via caveolin-1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Carbon Monoxide; C | 2009 |
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.
Topics: Active Transport, Cell Nucleus; Animals; Carbon Monoxide; Cells, Cultured; Cyclooxygenase 2; Cytokin | 2009 |
Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function.
Topics: Animals; Atrophy; Carbon Monoxide; Chronic Disease; Disease Models, Animal; Disease Progression; Dos | 2009 |
[Role of hydrogen sulfide/cystathionine-gamma-lyase system in acute lung injury induced by lipopolysaccharide in rats].
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Cystathionine gamma-Lyase; Disease Models, Animal; Heme | 2009 |
Low doses of carbon monoxide protect against experimental focal brain ischemia.
Topics: Analysis of Variance; Animals; Brain Edema; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Anim | 2009 |
Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.
Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Cell Degranulation; Cells, Cultured; Disease Mode | 2009 |
Role of heme oxygenase-1/carbon monoxide system in pulmonary ischemia-reperfusion injury.
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Enzyme Inhibitors; Female; Heme | 2009 |
Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo.
Topics: Analysis of Variance; Animals; Biliverdine; Carbon Monoxide; Cell Line, Tumor; Cell Proliferation; C | 2009 |
Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning.
Topics: Animals; Apoptosis; Carbon Monoxide; Carbon Monoxide Poisoning; Caspase 3; Disease Models, Animal; D | 2009 |
CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase.
Topics: Animals; Carbon Monoxide; Cell Adhesion; Cell Migration Assays, Leukocyte; Cell Movement; Cells, Cul | 2009 |
[Mechanism of endogenous carbon monoxide effect on hydrogen sulfide in guinea pigs with established allergic rhinitis].
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Guinea Pigs; Heme Oxygenase-1; Hydrogen Sulfide; I | 2009 |
Carbon monoxide pollution promotes cardiac remodeling and ventricular arrhythmia in healthy rats.
Topics: Air Pollutants; Air Pollution; Animals; Arrhythmias, Cardiac; Carbon Monoxide; Catalase; Disease Mod | 2010 |
Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1.
Topics: Angioplasty; Animals; Apoptosis; Arterial Occlusive Diseases; Carbon Monoxide; Cell Proliferation; C | 2010 |
Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antibodies; Carbon Monoxide; CD28 Ant | 2010 |
Disappearance of carbon monoxide from the blood: Comparison of the one-exponential and two-exponential elimination models for rat.
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Least-Squares Analysis; Male; M | 1981 |
The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model.
Topics: Animals; Arthritis, Experimental; Carbon Monoxide; Cartilage, Articular; Disease Models, Animal; Mal | 2010 |
Ex vivo application of carbon monoxide in UW solution prevents transplant-induced renal ischemia/reperfusion injury in pigs.
Topics: Animals; Blotting, Western; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Graft Surviv | 2010 |
Differential inhibition of mitochondrial respiratory complexes by inhalation of combustion smoke and carbon monoxide, in vivo, in the rat brain.
Topics: Animals; Brain; Carbon Monoxide; Disease Models, Animal; Electron Transport Chain Complex Proteins; | 2010 |
Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators.
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Cecum; Cytoprotection; Disease Models, Animal; Disulfir | 2010 |
VEGF promotes malaria-associated acute lung injury in mice.
Topics: Acute Lung Injury; Airway Obstruction; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Disease M | 2010 |
Protective effect of carbon monoxide inhalation on lung injury after hemorrhagic shock/resuscitation in rats.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Carbon Monoxide; Carboxyhemoglobin; Disease | 2010 |
[The anti-athetotic effects of heme-L-lysinate in a rabbit model of atherosclerosis].
Topics: Animals; Atherosclerosis; Carbon Monoxide; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, | 2010 |
Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Budesonide | 2010 |
Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation.
Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Carboxyhemoglobin; Cells, Cultured; Disease Model | 2010 |
Postconditioning of the lungs with inhaled carbon monoxide after cardiopulmonary bypass in pigs.
Topics: Administration, Inhalation; Animals; Apoptosis; Biopsy; Carbon Monoxide; Cardiopulmonary Bypass; Cas | 2011 |
Panhematin provides a therapeutic benefit in experimental pancreatitis.
Topics: Acute Disease; Animals; Arginine; Carbon Monoxide; Chemokine CXCL1; Cytokines; Disease Models, Anima | 2011 |
Investigation into the mechanism(s) of antithrombotic effects of carbon monoxide releasing molecule-3 (CORM-3).
Topics: Animals; Antithrombins; Blood Platelets; Carbon Monoxide; Disease Models, Animal; Humans; Male; Orga | 2011 |
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation.
Topics: Administration, Inhalation; Animals; Antioxidants; Autophagy; Carbon Monoxide; Cell Line, Tumor; Cyt | 2011 |
Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor.
Topics: Acetic Acid; Analgesics; Animals; Biliverdine; Carbon Monoxide; Cyclooxygenase 2 Inhibitors; Disease | 2011 |
An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis.
Topics: Animals; Blotting, Western; Carbon Monoxide; Cell Separation; Colitis; Cytokines; Disease Models, An | 2011 |
Sickle hemoglobin confers tolerance to Plasmodium infection.
Topics: Animals; Carbon Monoxide; CD8-Positive T-Lymphocytes; Chemokines; Crosses, Genetic; Disease Models, | 2011 |
Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Monoxide; Chemical | 2011 |
Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats.
Topics: Administration, Inhalation; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Monoxide; Caspase | 2011 |
Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model.
Topics: Animals; Apoptosis; Carbon Monoxide; Cardiotonic Agents; Caspase 3; Caspase 7; Cell Survival; Chemok | 2011 |
Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis.
Topics: Administration, Inhalation; Animals; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Fem | 2012 |
Relative importance of nitric oxide and carbon monoxide in regulating the ACTH response to immune and non-immune signals.
Topics: Adrenocorticotropic Hormone; Animals; Carbon Monoxide; Disease Models, Animal; Electric Stimulation; | 2001 |
Neither inhalative nor intravenous application of carbon monoxide modifies gastric mucosal oxygenation.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; Dogs; Female; Gastric | 2012 |
Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Cytokines; Disea | 2012 |
Inhalation of carbon monoxide reduces skeletal muscle injury after hind limb ischemia-reperfusion injury in mice.
Topics: Adenosine Triphosphate; Administration, Inhalation; Analysis of Variance; Animals; Blood Gas Analysi | 2012 |
Antithrombotic properties of water-soluble carbon monoxide-releasing molecules.
Topics: Animals; Arterial Occlusive Diseases; Blood Coagulation; Blood Gas Analysis; Blood Platelets; Blood | 2012 |
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.
Topics: Acetanilides; Action Potentials; Animals; Arrhythmias, Cardiac; Calcium Signaling; Carbon Monoxide; | 2012 |
Heme oxygenase 1-generated carbon monoxide and biliverdin attenuate the course of experimental necrotizing pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Ascites; Biliverdine; Carbon Monoxide; Deferoxamine; Disease Mode | 2013 |
Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN/LPS-induced acute liver injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Monoxide; Carboxyhemoglobin; Chemical and Drug Induced Live | 2013 |
Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes.
Topics: Animals; Autoantigens; Carbon Monoxide; CD8-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; | 2013 |
Inhalation of carbon monoxide following resuscitation ameliorates hemorrhagic shock-induced lung injury.
Topics: Acute Lung Injury; Animals; Apoptosis; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; G | 2013 |
Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice.
Topics: Animals; Caco-2 Cells; Carbon Monoxide; Disease Models, Animal; Enteritis; Humans; Ileitis; Inflamma | 2012 |
Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats.
Topics: Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Fe | 2013 |
Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance.
Topics: Animals; Bacterial Translocation; Blotting, Western; Carbon Monoxide; Colitis; Disease Models, Anima | 2013 |
A porcine model of the abdominal compartment syndrome.
Topics: Abdomen; Alanine Transaminase; Alkaline Phosphatase; Animals; Anuria; Carbon Monoxide; Compartment S | 2002 |
Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats.
Topics: Alkaline Phosphatase; Animals; Aorta, Thoracic; Calcinosis; Calcium; Carbon Monoxide; Cyclic GMP; Di | 2003 |
Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); L | 2003 |
Toxic gas protects rodent hearts.
Topics: Administration, Inhalation; Angioplasty, Balloon; Animals; Aorta; Carbon Monoxide; Disease Models, A | 2003 |
Effects of tin-protoporphyrin IX on blood flow in a rat tumor model.
Topics: Animals; Blood Flow Velocity; Carbon Monoxide; Carcinosarcoma; Disease Models, Animal; Enzyme Inhibi | 2003 |
[The effects of inhaled carbon monoxide on lung injury in rats caused by lipopolysaccharide].
Topics: Acute Disease; Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carbon Monoxide; D | 2003 |
Oxygen debt criteria quantify the effectiveness of early partial resuscitation after hypovolemic hemorrhagic shock.
Topics: Albumins; Animals; Blood Volume; Carbon Monoxide; Disease Models, Animal; Dogs; Fluid Therapy; Kidne | 2003 |
Physiologic responses of sheep to two different methods of papain exposure.
Topics: Administration, Inhalation; Aerosols; Animals; Bronchi; Carbon Monoxide; Diffusion; Disease Models, | 2003 |
Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.
Topics: Animals; Carbon Monoxide; Cardiotonic Agents; Cells, Cultured; Decanoic Acids; Disease Models, Anima | 2003 |
Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of recurrent febrile seizures.
Topics: Animals; Brain; Carbon Monoxide; Citrates; Cyclic GMP; Disease Models, Animal; Electrophoresis, Agar | 2004 |
Circulatory effects and kinetics following acute administration of carbon monoxide in a porcine model.
Topics: Animals; Blood Gas Analysis; Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; Cardiac O | 2004 |
Effects of inhaled carbon monoxide on acute lung injury in mice.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Cytokines; Disea | 2005 |
Carbon monoxide protects against the development of experimental necrotizing enterocolitis.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Carbon Monoxide; Cell Culture Tech | 2005 |
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.
Topics: Adenosine Triphosphate; Air; Animals; Carbon Monoxide; Cell Death; Cell Survival; Cytokines; Disease | 2005 |
"Therapeutic" carbon monoxide may be a reality soon.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Disease Models, Anim | 2005 |
Carbon monoxide and ileus: inhaled gas to prevent retained gas?
Topics: Abdomen; Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; Ileus; Postop | 2005 |
Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Carbon Monoxide; Disease Models, Animal; Male; Nicoti | 2005 |
The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model.
Topics: Animals; Bilirubin; Carbon Monoxide; Disease Models, Animal; Heme; Heme Oxygenase-1; Hyperbilirubine | 2006 |
Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Endothelin-1; Liver; Liver Circulation; Male; Mice | 2005 |
Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blood Coagulation; Carbon Monoxide; Carboxyhemoglobin; | 2005 |
Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Carboxyhemoglobin; Coronary Circulation; Cycli | 2006 |
Evaluation of the effects of a novel carbon monoxide releasing molecule (CORM-3) in an in vitro model of cardiovascular inflammation. 1. Histamine in allergy, inflammation, tissue growth and repair.
Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Disease Models, Animal; Endothelial Cells; Granul | 2006 |
Carbon monoxide orchestrates a protective response through PPARgamma.
Topics: Animals; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Early Growth Response Protein 1 | 2006 |
Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Antimetabolites; Carbon Monoxide; Disease Models, Animal; Glutathio | 2006 |
Central heme oxygenase-carbon monoxide pathway participates in the lipopolysaccharide-induced tolerance in rats.
Topics: Animals; Biliverdine; Body Temperature; Carbon Monoxide; Chlorides; Cyclic GMP; Disease Models, Anim | 2006 |
Carbon monoxide reverses established pulmonary hypertension.
Topics: Animals; Apoptosis; Carbon Monoxide; Cells, Cultured; Disease Models, Animal; Hemodynamics; Humans; | 2006 |
Effects of ambient particles and carbon monoxide on supraventricular arrhythmias in a rat model of myocardial infarction.
Topics: Air Pollutants; Animals; Arrhythmias, Cardiac; Carbon Monoxide; Disease Models, Animal; Male; Myocar | 2006 |
Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Blood Flow Velocity; Blood Pressure; Carbon Monoxide; Carboxyhe | 2007 |
[Protective effect of endogenous carbon monoxide on organs during septic shock in rat and its mechanisms].
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Heme Oxygenase-1; Liver; Lung; | 2007 |
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heme; Heme Oxygenase-1; Malaria, Cerebral; Mice; M | 2007 |
Heme moves to center stage in cerebral malaria.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heme; Heme Oxygenase-1; Malaria, Cerebral; Mice | 2007 |
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury.
Topics: Administration, Topical; Animals; Animals, Newborn; Bicuculline; Blood Pressure; Boranes; Bradykinin | 2007 |
The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow.
Topics: Alkynes; Animals; Aorta, Abdominal; Arteriovenous Shunt, Surgical; Carbon Monoxide; Cystathionine ga | 2007 |
Carbon monoxide can prevent acute lung injury observed after ischemia reperfusion of the lower extremities.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Bilirubin; Blood Pressure; Carbon Monoxide; Colo | 2007 |
Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cecum; Cell Adhesion; Cells, Cultured; Disease M | 2008 |
Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation.
Topics: Administration, Inhalation; Alanine Transaminase; Animals; Apoptosis Regulatory Proteins; Carbon Mon | 2008 |
[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns].
Topics: Animals; Burns; Carbon Monoxide; Cell Adhesion; Disease Models, Animal; Inflammation; Intercellular | 2007 |
Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Disease Models, Animal; Dose-Response Relationsh | 2008 |
Carbon monoxide has direct toxicity on the myocardium distinct from effects of hypoxia in an ex vivo rat heart model.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heart; Hypoxia; Rats; Reference Values | 2008 |
Inhaled CO in the treatment of acute lung injury.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; Humans; Mice; Respirat | 2008 |
[Molecular mechanism of inhibition of early pulmonary injury and inflammatory response by exogenous carbon monoxide: experiment with mice].
Topics: Animals; Blotting, Western; Burns; Carbon Monoxide; Cell Adhesion; Disease Models, Animal; Electroph | 2007 |
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1.
Topics: Airway Resistance; Animals; Antimetabolites; Blood Pressure; Carbon Monoxide; Disease Models, Animal | 2008 |
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease | 2008 |
Carbon monoxide enhances development of hypertension in Dahl rats.
Topics: Animals; Blood Pressure; Body Weight; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Fe | 1984 |
Atherosclerosis-related responses to cigarette smoking in the baboon.
Topics: Animals; Arteriosclerosis; Blood Glucose; Body Weight; Carbon Monoxide; Cholesterol; Cotinine; Diet; | 1980 |
Experimental diffuse alveolar damage in baboons.
Topics: Acute Disease; Animals; Carbon Monoxide; Disease Models, Animal; Male; Oleic Acid; Oleic Acids; Oxyg | 1982 |
In vivo lung lavage as an experimental model of the respiratory distress syndrome.
Topics: Animals; Blood Gas Analysis; Carbon Monoxide; Disease Models, Animal; Guinea Pigs; Lung; Respiratory | 1980 |
Morphology of cardiac muscle in septic shock. Observations with a porcine septic shock model.
Topics: Animals; Carbon Monoxide; Cardiac Output; Disease Models, Animal; Muscle, Skeletal; Myocardium; Shoc | 1995 |
[Experimental techniques for developing new drugs acting on dementia (6)--Carbon monoxide-induced amnesia model in experimental animals].
Topics: Amnesia; Animals; Avoidance Learning; Brain; Carbon Monoxide; Catecholamines; Disease Models, Animal | 1994 |
Combined carbon monoxide and cyanide poisoning: a place for treatment.
Topics: Animals; Carbon Dioxide; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Cyanides; Di | 1995 |
Pathophysiologic correlations in lymphoid interstitial pneumonia.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Female; Linear Models; Lung Compliance; Lung Volum | 1994 |
In-vitro mechanisms of 1,2-dichloropropane nephrotoxicity using the renal cortical slice model.
Topics: Alanine Transaminase; Animals; Carbon Monoxide; Disease Models, Animal; gamma-Glutamyltransferase; G | 1993 |
Cholecystokinin-related peptides, after systemic or central administration, prevent carbon monoxide-induced amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Monoxide; Ceruletide; Disease Models, Animal; Injection | 1994 |
Amiodarone-induced pulmonary fibrosis in Fischer 344 rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Carbon Monoxide; Diffusion; Disease Models, Animal; Fem | 1996 |
L-arginine decreases infarct size in rats exposed to environmental tobacco smoke.
Topics: Animals; Aorta, Abdominal; Arginine; Blood Pressure; Carbon Monoxide; Disease Models, Animal; Endoth | 1996 |
Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets.
Topics: Animals; Blood Pressure; Brain; Carbon Monoxide; Carotid Artery, Internal; Disease Models, Animal; H | 1996 |
Pulmonary mechanical and immunologic dysfunction in a murine model of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Carbon Monoxide; Collagen; Cytokines; Disease Models, A | 1997 |
Mechanism of oxidative stress from low levels of carbon monoxide.
Topics: Air Pollutants; Animals; Arteriosclerosis; Blood Platelets; Carbon Monoxide; Cattle; Cells, Cultured | 1997 |
Carbon monoxide, a cyclic GMP-related messenger, involved in hypoxic bronchodilation in vivo.
Topics: Airway Resistance; Animals; Bronchi; Carbon Monoxide; Cyclic GMP; Disease Models, Animal; Guinea Pig | 1998 |
Blood volume determination by the carbon monoxide method using a new delivery system: accuracy in critically ill humans and precision in an animal model.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Animals; Blood Volume; Blood Volume Dete | 1999 |
Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Fem | 2000 |
Prenatal exposure model simulating CO inhalation in human cigarette smokers: sphingomyelin alterations in the rat sciatic nerve.
Topics: Administration, Inhalation; Air Pollutants; Animals; Brain; Carbon Monoxide; Carboxyhemoglobin; Dise | 2000 |
Inhibition of hypoxic pulmonary vasoconstriction by carbon monoxide in dogs.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Cyclooxygenase Inhibitors; Disease Models, Ani | 2001 |
[Combined effects of psychoemotional stress and carbon monoxide in experiments].
Topics: Affect; Air; Animals; Carbon Monoxide; Disease Models, Animal; Stress, Psychological; T-Lymphocytes | 2001 |
Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle.
Topics: Acetates; Amines; Amino Acids, Branched-Chain; Animals; Brain; Carbon Monoxide; Cells, Cultured; Cer | 2001 |
[Evidence of increased endogenous carbon monoxide production in asthma].
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Cell Line; Child; Child, Preschool; | 1999 |
[The expression and regulation of heme oxygenase-1 in asthmatic guinea pigs].
Topics: Animals; Asthma; Carbon Monoxide; Cyclic GMP; Disease Models, Animal; Gene Expression Regulation, En | 1999 |
Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.
Topics: Animals; Bleomycin; Blood Gas Analysis; Carbon Monoxide; Cricetinae; Disease Models, Animal; Lung; L | 1978 |
Cigarette smoking baboon model: demonstration of feasibility.
Topics: Animals; Arteriosclerosis; Behavior, Animal; Carbon Monoxide; Cardiovascular System; Disease Models, | 1978 |
Atherogenesis in the White Carneau pigeon. Further studies of the role of carbon monoxide and dietary cholesterol.
Topics: Animals; Arteriosclerosis; Carbon Monoxide; Cholesterol, Dietary; Columbidae; Disease Models, Animal | 1979 |
Failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (Macaca fascicularis).
Topics: Animals; Aorta; Arteriosclerosis; Carbon Monoxide; Cholesterol, Dietary; Coronary Vessels; Disease M | 1976 |
Toxicity of mild prenatal carbon monoxide exposure.
Topics: Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Body Weight; Brain; Carbon Monoxide; Dise | 1977 |
Comparative studies concerning the suitability of European hamsters and Syrian golden hamsters for investigations on smoke exposure.
Topics: Animals; Carbon Monoxide; Carboxyhemoglobin; Cricetinae; Disease Models, Animal; Evaluation Studies | 1975 |
Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature.
Topics: Animals; Body Temperature; Carbon Monoxide; Cell Survival; Disease Models, Animal; Dizocilpine Malea | 1991 |
[Biochemical and histopathological studies on a mouse brain ischemic model induced by bilateral carotid artery occlusion: comparison with the carbon monoxide inhalation method and other ischemic or anoxic models].
Topics: Acetylcholine; Adenosine Triphosphate; Administration, Inhalation; Animals; Brain; Brain Ischemia; C | 1991 |
[Ontogenetic characteristics of the body response to chronic exposure to chemical substances].
Topics: Adaptation, Physiological; Administration, Inhalation; Age Factors; Animals; Carbon Monoxide; Diseas | 1991 |
The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine.
Topics: Administration, Inhalation; Animals; Carbon Monoxide; Disease Models, Animal; DNA; Dose-Response Rel | 1991 |
Increased carbon monoxide excretion in Bolivian squirrel monkeys with fasting hyperbilirubinemia.
Topics: Animals; Bilirubin; Bolivia; Brazil; Carbon Monoxide; Disease Models, Animal; Fasting; Gilbert Disea | 1990 |
Exacerbation of acute platelet thrombus formation in stenosed dog coronary arteries with smoke from a non-tobacco-burning cigarette.
Topics: Animals; Blood Platelets; Blood Pressure; Carbon Monoxide; Coronary Artery Disease; Coronary Circula | 1990 |
The pathophysiology of carbon monoxide poisoning and acute respiratory failure in a sheep model with smoke inhalation injury.
Topics: Acute Disease; Animals; Bronchi; Carbon Monoxide; Carbon Monoxide Poisoning; Disease Models, Animal; | 1990 |
Carbon monoxide (CO)-induced hypoxia in mice: evaluation as an experimental model of cerebral ischemia for drug screening.
Topics: Animals; Brain Ischemia; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; Drug Evaluation | 1989 |
Carbon monoxide excretion as an index of bilirubin production in rhesus monkeys.
Topics: Animals; Animals, Newborn; Bilirubin; Carbon Monoxide; Carboxyhemoglobin; Disease Models, Animal; He | 1989 |
Carbon monoxide exposure potentiates high-frequency auditory threshold shifts induced by noise.
Topics: Animals; Audiometry, Pure-Tone; Auditory Threshold; Carbon Monoxide; Disease Models, Animal; Hearing | 1987 |
Age and survival of an acute carbon monoxide intoxication: an animal model.
Topics: Aging; Animals; Body Temperature; Body Weight; Carbon Monoxide; Disease Models, Animal; Female; Hear | 1987 |
Cardiovascular status of female beagles exposed to air pollutants.
Topics: Air Pollution; Animals; Arteriosclerosis; Carbon Monoxide; Cardiovascular Diseases; Cardiovascular S | 1972 |
Experimental papain-induced emphysema in dogs.
Topics: Airway Resistance; Animals; Carbon Dioxide; Carbon Monoxide; Diffusion; Disease Models, Animal; Dogs | 1970 |
[Study of the microcirculation of the lung after an abrupt exclusion of the pulmonary flow].
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Animals; Carbon Dioxide; Carbon Monoxide; Disease Mode | 1970 |