Page last updated: 2024-10-16

carbon monoxide and Direct Hyperbilirubinemia, Neonatal

carbon monoxide has been researched along with Direct Hyperbilirubinemia, Neonatal in 11 studies

Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.

Research Excerpts

ExcerptRelevanceReference
"The predominant cause of elevated total/plasma bilirubin (TB) levels is from an increase in bilirubin production primarily because of ongoing hemolysis."9.12Neonatal hyperbilirubinemia management: Clinical assessment of bilirubin production. ( Bao, Y; Bhutani, VK; Chen, L; Du, L; Ma, X; Shen, X, 2021)
" Because the catabolism of heme produces equimolar amounts of carbon monoxide (CO) and bilirubin, measurements of end-tidal breath CO (corrected for ambient CO) or ETCOc can serve as an index of hemolysis as well as of bilirubin production from any cause."8.90End-tidal carbon monoxide and hemolysis. ( Stevenson, DK; Tidmarsh, GF; Wong, RJ, 2014)
"The predominant cause of elevated total/plasma bilirubin (TB) levels is from an increase in bilirubin production primarily because of ongoing hemolysis."5.12Neonatal hyperbilirubinemia management: Clinical assessment of bilirubin production. ( Bao, Y; Bhutani, VK; Chen, L; Du, L; Ma, X; Shen, X, 2021)
" Because the catabolism of heme produces equimolar amounts of carbon monoxide (CO) and bilirubin, measurements of end-tidal breath CO (corrected for ambient CO) or ETCOc can serve as an index of hemolysis as well as of bilirubin production from any cause."4.90End-tidal carbon monoxide and hemolysis. ( Stevenson, DK; Tidmarsh, GF; Wong, RJ, 2014)
"To establish a reference nomogram for end-tidal CO corrected for ambient CO (ETCOc) levels in term and late-preterm Chinese newborns and then assess its efficacy to identify hemolytic hyperbilirubinemia."4.12An End-Tidal Carbon Monoxide Nomogram for Term and Late-Preterm Chinese Newborns. ( Bao, Y; Du, L; He, Y; Ma, L; Sun, L; Wu, J; Xu, C; Zhang, H; Zhu, J, 2022)
"Increased bilirubin production due to hemolysis can lead to severe neonatal hyperbilirubinemia and, if left untreated, to bilirubin neurotoxicity."3.91Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane. ( Burgess, J; Iwatani, S; Kalish, F; Stevenson, DK; Wong, RJ, 2019)
"Hyperbilirubinemia risk was assessed by plotting TB values as a function of ETCOc."2.82Identification of neonatal haemolysis: an approach to predischarge management of neonatal hyperbilirubinemia. ( Aby, JL; Bhutani, VK; Castillo Cuadrado, ME; Srinivas, S; Stevenson, DK; Wong, RJ, 2016)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (54.55)24.3611
2020's5 (45.45)2.80

Authors

AuthorsStudies
Bao, Y2
Zhu, J1
Ma, L1
Zhang, H1
Sun, L1
Xu, C1
Wu, J1
He, Y1
Du, L2
Stevenson, DK7
Wong, RJ7
Ostrander, CR1
Maric, I1
Vreman, HJ2
Cohen, RS1
Elsaie, AL1
Taleb, M1
Nicosia, A1
Zangaladze, A1
Pease, ME1
Newton, K1
Schutzman, DL2
Ma, X1
Shen, X1
Chen, L1
Bhutani, VK3
Bahr, TM1
Shakib, JH1
Stipelman, CH1
Kawamoto, K1
Lauer, S1
Christensen, RD2
Maisels, MJ1
Castillo Cuadrado, ME2
Aby, JL2
Bogen, DL1
Watchko, JF1
Iwatani, S1
Burgess, J1
Kalish, F1
Tidmarsh, GF1
Srinivas, S1
He, CX1
Campbell, CM1
Zhao, H1
Kalish, FS1
Schulz, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on the Intelligent Follow-up Management Model of Neonatal Jaundice After Discharge Based on Early Multi-dimensional Indicators and Internet Communications[NCT05365984]2,500 participants (Anticipated)Interventional2022-05-31Not yet recruiting
End Tidal Carbon Monoxide (ETCO) : A Tool to Aid Identification of Neonatal Hemolysis[NCT05475223]350 participants (Anticipated)Interventional2022-07-29Not yet recruiting
Clinical Value of ETCOc in the Diagnosis and Treatment of ABO Hemolytic Disease of the Newborn[NCT05842109]112 participants (Anticipated)Observational2023-05-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for carbon monoxide and Direct Hyperbilirubinemia, Neonatal

ArticleYear
Neonatal hyperbilirubinemia management: Clinical assessment of bilirubin production.
    Seminars in perinatology, 2021, Volume: 45, Issue:1

    Topics: Bilirubin; Carbon Monoxide; Hemolysis; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Neonatal; Inf

2021
End-tidal carbon monoxide and hemolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:8

    Topics: Breath Tests; Carbon Monoxide; Hemolysis; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Tid

2014
End-tidal carbon monoxide and hemolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:8

    Topics: Breath Tests; Carbon Monoxide; Hemolysis; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Tid

2014
End-tidal carbon monoxide and hemolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:8

    Topics: Breath Tests; Carbon Monoxide; Hemolysis; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Tid

2014
End-tidal carbon monoxide and hemolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:8

    Topics: Breath Tests; Carbon Monoxide; Hemolysis; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Tid

2014
Neonatal hemolysis and risk of bilirubin-induced neurologic dysfunction.
    Seminars in fetal & neonatal medicine, 2015, Volume: 20, Issue:1

    Topics: Carbon Monoxide; Genetic Predisposition to Disease; Glucosephosphate Dehydrogenase Deficiency; Hemol

2015

Trials

1 trial available for carbon monoxide and Direct Hyperbilirubinemia, Neonatal

ArticleYear
Identification of neonatal haemolysis: an approach to predischarge management of neonatal hyperbilirubinemia.
    Acta paediatrica (Oslo, Norway : 1992), 2016, Volume: 105, Issue:5

    Topics: Algorithms; Bilirubin; Biomarkers; Carbon Monoxide; Clinical Decision-Making; Decision Support Techn

2016

Other Studies

7 other studies available for carbon monoxide and Direct Hyperbilirubinemia, Neonatal

ArticleYear
An End-Tidal Carbon Monoxide Nomogram for Term and Late-Preterm Chinese Newborns.
    The Journal of pediatrics, 2022, Volume: 250

    Topics: Bilirubin; Carbon Monoxide; China; Hemolysis; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Neonat

2022
Increased Carbon Monoxide Washout Rates in Newborn Infants.
    Neonatology, 2020, Volume: 117, Issue:1

    Topics: Bilirubin; Carbon Monoxide; Carboxyhemoglobin; Healthy Volunteers; Hemolysis; Humans; Hyperbilirubin

2020
Comparison of end-tidal carbon monoxide measurements with direct antiglobulin tests in the management of neonatal hyperbilirubinemia.
    Journal of perinatology : official journal of the California Perinatal Association, 2020, Volume: 40, Issue:10

    Topics: Bilirubin; Carbon Monoxide; Child; Coombs Test; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Neon

2020
Improvement Initiative: End-Tidal Carbon Monoxide Measurement in Newborns Receiving Phototherapy.
    The Journal of pediatrics, 2021, Volume: 238

    Topics: Blood Gas Monitoring, Transcutaneous; Carbon Monoxide; Diagnostic Tests, Routine; Feasibility Studie

2021
Identification of risk for neonatal haemolysis.
    Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:8

    Topics: Analysis of Variance; Bilirubin; Carbon Monoxide; Cohort Studies; Female; Gestational Age; Hemolysis

2018
Bilirubin Production Is Increased in Newborn Mice Exposed to Isoflurane.
    Neonatology, 2019, Volume: 115, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Bilirubin; Carbon Monoxide; Female; Heme Oxygena

2019
Effects of zinc deuteroporphyrin bis glycol on newborn mice after heme loading.
    Pediatric research, 2011, Volume: 70, Issue:5

    Topics: Animals; Animals, Newborn; Bilirubin; Blotting, Western; Carbon Monoxide; Chromatography, Gas; Deute

2011