carbon monoxide has been researched along with Blood Poisoning in 69 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Low-dose inhaled carbon monoxide (iCO) confers cytoprotection in preclinical models of sepsis and ARDS." | 9.27 | A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. ( Baron, RM; Barragan-Bradford, D; Berlin, DA; Bouthot, M; Choi, AM; Davies, JD; Dieffenbach, PB; Englert, JA; Finkelsztein, E; Fredenburgh, LE; Harris, RS; Hess, DR; Higuera, A; Hurwitz, S; Kone, MT; Kraft, BD; Lagambina, S; Malik, MJ; Maurer, R; Nakahira, K; Nuccio, PF; Oromendia, C; Perrella, MA; Peters, E; Piantadosi, CA; Porras, MAP; Schiffer, KT; Serhan, CN; Sullivan, AI; Thompson, BT; Welty-Wolf, KE; Winkler, T, 2018) |
| "There is ample evidence that nitric oxide, carbon monoxide, and H2S may exert cytoprotective effects in shock states due to their vasomotor, antioxidant, and anti-inflammatory properties as well as their potential to induce a hibernation-like metabolic state called 'suspended animation' resulting from inhibition of cytochrome-c-oxidase." | 8.85 | Applying gases for microcirculatory and cellular oxygenation in sepsis: effects of nitric oxide, carbon monoxide, and hydrogen sulfide. ( Baumgart, K; Radermacher, P; Wagner, F, 2009) |
| "Carbon monoxide (CO) can exert potent anti-inflammatory effects in animal and cell culture models of sepsis, despite well-known lethal effects at high concentration." | 8.84 | Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models. ( Choi, AM; Ryter, SW, 2007) |
| "BACKGROUND Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis." | 7.96 | Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture. ( Dong, J; Liu, X; Qin, H; Shao, M; Wang, H; Wu, F; Zhang, H; Zhang, J; Zhang, S; Zhang, W; Zhao, H; Zhao, Y; Zhao, Z, 2020) |
| "To investigate the protective effect of carbon monoxide release molecule-2 (CORM-2) on sepsis-induced myocardial dysfunction in rats." | 7.91 | [Effects of carbon monoxide release molecule-2 on sepsis-induced myocardial dysfunction in rats]. ( Qi, W; Wang, F; Wang, X; Xu, Y; Zhang, S, 2019) |
| "The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration." | 7.88 | The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. ( Aki, T; Nagano, S; Uemura, K; Unuma, K; Watanabe, R, 2018) |
| "Ex vivo preconditioning with carbon monoxide allowed mesenchymal stromal cells to be administered later after the onset of sepsis (6 hr), and yet maintain their therapeutic effect with increased survival." | 7.83 | Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. ( Baron, RM; Choi, AM; Colas, RA; Coronata, A; Dalli, J; Fredenburgh, LE; Ghanta, S; Hall, SR; Ith, B; Liu, X; Perrella, MA; Serhan, CN; Tsoyi, K, 2016) |
| "Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated." | 7.81 | Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015) |
| "Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet." | 7.81 | Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats. ( Chang, R; Huang, J; Huang, Z; Li, Y; Lin, J; Wang, P; Wu, H, 2015) |
| " Here we investigate whether exogenous carbon monoxide can protect cardiac function and improve survival against sepsis by interfering with mitochondrial energetic metabolism." | 7.80 | A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway. ( Cao, J; Liu, D; Qin, W; Qiu, X; Sun, B; Wang, X, 2014) |
| " Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear." | 7.80 | Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014) |
| " In this study, we assessed the role of CO donor, methylene chloride (MC), on modulation of lung inflammation during sepsis." | 7.76 | Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators. ( Dou, L; He, J; Pan, X; Pang, Q; Xu, W; Zeng, S; Zeng, Y, 2010) |
| "To study the inhibitive effect of exogenous carbon monoxide-releasing molecules 2 (CORM-2) on the activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in sepsis." | 7.76 | [Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on the activation of Janus kinase/signal transducer and activator of transcription pathway in sepsis]. ( Shi, GS; Sun, BW; Sun, Y; Zhang, P; Zou, XQ, 2010) |
| "Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects." | 7.75 | Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. ( Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Motterlini, R; Neviere, R, 2009) |
| "A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis." | 7.71 | Increased endogenous carbon monoxide production in severe sepsis. ( Boiteau, R; Burdin, M; Perrin, D; Tenaillon, A; Zegdi, R, 2002) |
| "Sepsis is is anabnormalhost immune responsecausedbyinfection." | 7.01 | Application and value of hydrogen sulfide modulated autophagy in sepsis. ( Liu, C; Sun, Y, 2023) |
| "Sepsis is a common and serious medical condition caused by hemorrhage, trauma, or abdominal surgery." | 6.45 | Carbon monoxide releasing molecules: new insights for anticoagulation strategy in sepsis. ( Chen, X; Sun, BW, 2009) |
| "Sepsis is characterized by a systemic response to severe infection." | 5.35 | Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008) |
| " Low-dose inhaled carbon monoxide (iCO) confers cytoprotection in preclinical models of sepsis and ARDS." | 5.27 | A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. ( Baron, RM; Barragan-Bradford, D; Berlin, DA; Bouthot, M; Choi, AM; Davies, JD; Dieffenbach, PB; Englert, JA; Finkelsztein, E; Fredenburgh, LE; Harris, RS; Hess, DR; Higuera, A; Hurwitz, S; Kone, MT; Kraft, BD; Lagambina, S; Malik, MJ; Maurer, R; Nakahira, K; Nuccio, PF; Oromendia, C; Perrella, MA; Peters, E; Piantadosi, CA; Porras, MAP; Schiffer, KT; Serhan, CN; Sullivan, AI; Thompson, BT; Welty-Wolf, KE; Winkler, T, 2018) |
| "Carbon monoxide derived from haem oxygenase (HO)-2 is predominantly involved in neuromodulation and in setting the smooth muscle membrane potential, while CO derived from HO-1 has anti-inflammatory and antioxidative properties, which protect gastrointestinal smooth muscle from damage caused by injury or inflammation." | 4.89 | Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics. ( Bharucha, A; Farrugia, G; Gibbons, SJ; Verhulst, PJ, 2013) |
| "There is ample evidence that nitric oxide, carbon monoxide, and H2S may exert cytoprotective effects in shock states due to their vasomotor, antioxidant, and anti-inflammatory properties as well as their potential to induce a hibernation-like metabolic state called 'suspended animation' resulting from inhibition of cytochrome-c-oxidase." | 4.85 | Applying gases for microcirculatory and cellular oxygenation in sepsis: effects of nitric oxide, carbon monoxide, and hydrogen sulfide. ( Baumgart, K; Radermacher, P; Wagner, F, 2009) |
| "Carbon monoxide (CO) can exert potent anti-inflammatory effects in animal and cell culture models of sepsis, despite well-known lethal effects at high concentration." | 4.84 | Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models. ( Choi, AM; Ryter, SW, 2007) |
| "Carboxyhemoglobin (COHb) is an index of endogenous carbon monoxide formation during the hem degradation process and could be used to confirm hemolysis in neonates." | 4.12 | Clinical Factors Influencing Endogenous Carbon Monoxide Production and Carboxyhemoglobin Levels in Neonates. ( Lozar Krivec, J; Lozar Manfreda, K; Paro-Panjan, D, 2022) |
| "BACKGROUND Carbon monoxide (CO) has anti-inflammatory effects and protects the intestinal mucosal barrier in sepsis." | 3.96 | Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture. ( Dong, J; Liu, X; Qin, H; Shao, M; Wang, H; Wu, F; Zhang, H; Zhang, J; Zhang, S; Zhang, W; Zhao, H; Zhao, Y; Zhao, Z, 2020) |
| "To investigate the protective effect of carbon monoxide release molecule-2 (CORM-2) on sepsis-induced myocardial dysfunction in rats." | 3.91 | [Effects of carbon monoxide release molecule-2 on sepsis-induced myocardial dysfunction in rats]. ( Qi, W; Wang, F; Wang, X; Xu, Y; Zhang, S, 2019) |
| "The present study aimed to investigate the effect of carbon monoxide (CO)‑releasing molecule‑2 (CORM‑2) on pancreatic function in sepsis‑model mice." | 3.91 | Protective effects of carbon monoxide releasing molecule‑2 on pancreatic function in septic mice. ( Liu, Y; Qin, W; Sun, B; Wang, X; Xu, X, 2019) |
| "The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration." | 3.88 | The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. ( Aki, T; Nagano, S; Uemura, K; Unuma, K; Watanabe, R, 2018) |
| "Ex vivo preconditioning with carbon monoxide allowed mesenchymal stromal cells to be administered later after the onset of sepsis (6 hr), and yet maintain their therapeutic effect with increased survival." | 3.83 | Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. ( Baron, RM; Choi, AM; Colas, RA; Coronata, A; Dalli, J; Fredenburgh, LE; Ghanta, S; Hall, SR; Ith, B; Liu, X; Perrella, MA; Serhan, CN; Tsoyi, K, 2016) |
| "Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet." | 3.81 | Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats. ( Chang, R; Huang, J; Huang, Z; Li, Y; Lin, J; Wang, P; Wu, H, 2015) |
| "Carbon monoxide (CO) released from CORM-2 has anti-inflammatory function, but the critical molecule mediating the inflammation inhibition has not been elucidated." | 3.81 | Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. ( Cao, W; Du, R; Liu, X; Qin, S; Xu, G; Yin, S, 2015) |
| " Carbon monoxide (CO), when administered at low physiologic doses, can modulate cell proliferation, apoptosis, and inflammation in pre-clinical tissue injury models, though its mechanism of action in sepsis remains unclear." | 3.80 | Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. ( Choi, AM; Chung, SW; Coronata, AA; Fredenburgh, LE; Lee, S; Lee, SJ; Nakahira, K; Perrella, MA; Ryter, SW, 2014) |
| "To investigate the possible mechanisms of exogenous carbon monoxide-releasing molecule II (CORM-2) intervention on hepatic energy metabolism in experimental sepsis." | 3.80 | Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice. ( Cao, J; Liang, F; Qin, WT; Qiu, XF; Sun, BW; Wang, X, 2014) |
| " Here we investigate whether exogenous carbon monoxide can protect cardiac function and improve survival against sepsis by interfering with mitochondrial energetic metabolism." | 3.80 | A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway. ( Cao, J; Liu, D; Qin, W; Qiu, X; Sun, B; Wang, X, 2014) |
| " In this study, we assessed the role of CO donor, methylene chloride (MC), on modulation of lung inflammation during sepsis." | 3.76 | Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators. ( Dou, L; He, J; Pan, X; Pang, Q; Xu, W; Zeng, S; Zeng, Y, 2010) |
| "To study the inhibitive effect of exogenous carbon monoxide-releasing molecules 2 (CORM-2) on the activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in sepsis." | 3.76 | [Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on the activation of Janus kinase/signal transducer and activator of transcription pathway in sepsis]. ( Shi, GS; Sun, BW; Sun, Y; Zhang, P; Zou, XQ, 2010) |
| "Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects." | 3.75 | Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. ( Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Motterlini, R; Neviere, R, 2009) |
| "A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis." | 3.71 | Increased endogenous carbon monoxide production in severe sepsis. ( Boiteau, R; Burdin, M; Perrin, D; Tenaillon, A; Zegdi, R, 2002) |
| "Sepsis is is anabnormalhost immune responsecausedbyinfection." | 3.01 | Application and value of hydrogen sulfide modulated autophagy in sepsis. ( Liu, C; Sun, Y, 2023) |
| "Although many diseases, including cancer, hematological diseases, hypertension, heart failure, inflammation, sepsis, neurodegeneration, and sleep disorders, have been linked to abnormal endogenous CO metabolism and functions, CO administration has therapeutic potential in inflammation, sepsis, lung injury, cardiovascular diseases, transplantation, and cancer." | 2.48 | Carbon monoxide: an unusual drug. ( Ascenzi, P; di Masi, A; Gullotta, F, 2012) |
| "Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain major causes of morbidity and mortality in critical care medicine despite advances in therapeutic modalities." | 2.46 | Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine. ( Choi, AM; Ryter, SW, 2010) |
| "Sepsis is a common and serious medical condition caused by hemorrhage, trauma, or abdominal surgery." | 2.45 | Carbon monoxide releasing molecules: new insights for anticoagulation strategy in sepsis. ( Chen, X; Sun, BW, 2009) |
| "Inhaled carbon monoxide (CO) gas has therapeutic potential for patients with acute respiratory distress syndrome if a safe, evidence-based dosing strategy and a ventilator-compatible CO delivery system can be developed." | 1.42 | Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. ( Baron, RM; Choi, AM; Davies, JD; Fredenburgh, LE; Harris, RS; Hess, DR; Kraft, BD; Piantadosi, CA; Roggli, VL; Stenzler, A; Suliman, HB; Thompson, BT; Welty-Wolf, KE; Winkler, T; Wolf, MA, 2015) |
| "Sepsis is characterized by a systemic response to severe infection." | 1.35 | Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. ( Baron, RM; Chung, SW; Liu, X; Macias, AA; Perrella, MA, 2008) |
| "Sepsis was induced in male Sprague-Dawley rats by cecal ligation and puncture (CLP)." | 1.32 | Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats. ( Iwasashi, H; Kondo, N; Matsuno, S; Oikawa, M; Suzuki, M; Unno, M; Utiyama, T, 2003) |
| "The fact that wound sepsis is still prevalent is emphasized, and recent researches on bacterial inhibition under hyperbaric oxygen are described." | 1.24 | THE LISTER LECTURE, 1964: WOUND SEPSIS-FROM CARBOLIC ACID TO HYPERBARIC OXYGEN. ( ILLINGWORTH, C, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.45) | 18.7374 |
| 1990's | 2 (2.90) | 18.2507 |
| 2000's | 22 (31.88) | 29.6817 |
| 2010's | 39 (56.52) | 24.3611 |
| 2020's | 5 (7.25) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 2 |
| Liu, C | 1 |
| Zhang, S | 2 |
| Qi, W | 1 |
| Wang, F | 1 |
| Xu, Y | 1 |
| Wang, X | 9 |
| Zhuang, M | 2 |
| Song, M | 3 |
| Liu, D | 3 |
| Huang, J | 2 |
| Sun, B | 6 |
| Joe, Y | 4 |
| Chen, Y | 2 |
| Park, J | 1 |
| Kim, HJ | 4 |
| Rah, SY | 1 |
| Ryu, J | 1 |
| Cho, GJ | 2 |
| Choi, HS | 1 |
| Ryter, SW | 9 |
| Park, JW | 1 |
| Kim, UH | 1 |
| Chung, HT | 5 |
| Wang, H | 1 |
| Zhao, H | 1 |
| Qin, H | 1 |
| Zhang, J | 2 |
| Dong, J | 1 |
| Zhang, H | 1 |
| Liu, X | 4 |
| Zhao, Z | 1 |
| Zhao, Y | 1 |
| Shao, M | 1 |
| Wu, F | 1 |
| Zhang, W | 2 |
| Lozar Krivec, J | 1 |
| Lozar Manfreda, K | 1 |
| Paro-Panjan, D | 1 |
| Unuma, K | 1 |
| Aki, T | 1 |
| Nagano, S | 1 |
| Watanabe, R | 1 |
| Uemura, K | 1 |
| Fredenburgh, LE | 4 |
| Perrella, MA | 4 |
| Barragan-Bradford, D | 1 |
| Hess, DR | 2 |
| Peters, E | 1 |
| Welty-Wolf, KE | 4 |
| Kraft, BD | 2 |
| Harris, RS | 2 |
| Maurer, R | 1 |
| Nakahira, K | 3 |
| Oromendia, C | 1 |
| Davies, JD | 2 |
| Higuera, A | 1 |
| Schiffer, KT | 1 |
| Englert, JA | 1 |
| Dieffenbach, PB | 1 |
| Berlin, DA | 1 |
| Lagambina, S | 1 |
| Bouthot, M | 1 |
| Sullivan, AI | 1 |
| Nuccio, PF | 1 |
| Kone, MT | 1 |
| Malik, MJ | 1 |
| Porras, MAP | 1 |
| Finkelsztein, E | 1 |
| Winkler, T | 2 |
| Hurwitz, S | 1 |
| Serhan, CN | 2 |
| Piantadosi, CA | 4 |
| Baron, RM | 4 |
| Thompson, BT | 2 |
| Choi, AM | 9 |
| Liu, Y | 1 |
| Xu, X | 2 |
| Qin, W | 5 |
| Lee, S | 1 |
| Lee, SJ | 1 |
| Coronata, AA | 1 |
| Chung, SW | 2 |
| Gibbons, SJ | 1 |
| Verhulst, PJ | 1 |
| Bharucha, A | 1 |
| Farrugia, G | 1 |
| Kim, SK | 2 |
| Zheng, M | 1 |
| Yu, JK | 1 |
| Chang, KC | 3 |
| Kim, HK | 1 |
| Han, J | 1 |
| Lv, W | 1 |
| Liang, F | 2 |
| Cao, J | 3 |
| Qin, WT | 2 |
| Qiu, XF | 2 |
| Sun, BW | 5 |
| Qiu, X | 1 |
| Wegiel, B | 2 |
| Larsen, R | 1 |
| Gallo, D | 1 |
| Chin, BY | 2 |
| Harris, C | 1 |
| Mannam, P | 1 |
| Kaczmarek, E | 1 |
| Lee, PJ | 1 |
| Zuckerbraun, BS | 2 |
| Flavell, R | 1 |
| Soares, MP | 1 |
| Otterbein, LE | 3 |
| Shen, WC | 1 |
| Jamal Uddin, M | 1 |
| Oh Jeong, S | 1 |
| Pae, HO | 1 |
| Kim, SR | 1 |
| Ha, YM | 1 |
| Kim, YM | 1 |
| Park, EJ | 1 |
| Kim, JW | 1 |
| Park, SW | 1 |
| Qin, S | 1 |
| Du, R | 1 |
| Yin, S | 1 |
| Xu, G | 1 |
| Cao, W | 1 |
| Wolf, MA | 1 |
| Suliman, HB | 3 |
| Roggli, VL | 1 |
| Stenzler, A | 1 |
| Wang, P | 1 |
| Li, Y | 1 |
| Chang, R | 1 |
| Wu, H | 1 |
| Lin, J | 1 |
| Huang, Z | 1 |
| Uddin, MJ | 1 |
| Li, CS | 1 |
| Zhang, Q | 1 |
| Zhang, Y | 1 |
| Tsoyi, K | 2 |
| Hall, SR | 1 |
| Dalli, J | 1 |
| Colas, RA | 1 |
| Ghanta, S | 1 |
| Ith, B | 1 |
| Coronata, A | 1 |
| Tao, A | 1 |
| Lan, T | 1 |
| Cepinskas, G | 3 |
| Kao, R | 1 |
| Martin, CM | 1 |
| Rui, T | 1 |
| Buechler, C | 1 |
| Pohl, R | 1 |
| Aslanidis, C | 1 |
| Chen, X | 1 |
| Lancel, S | 1 |
| Hassoun, SM | 1 |
| Favory, R | 1 |
| Decoster, B | 1 |
| Motterlini, R | 1 |
| Neviere, R | 1 |
| Clemens, MG | 1 |
| Lee, TY | 1 |
| Lee, YS | 1 |
| Seo, HG | 1 |
| Lee, JH | 1 |
| Baumgart, K | 1 |
| Radermacher, P | 1 |
| Wagner, F | 1 |
| Mizuguchi, S | 1 |
| Stephen, J | 1 |
| Bihari, R | 1 |
| Markovic, N | 1 |
| Suehiro, S | 1 |
| Capretta, A | 1 |
| Potter, RF | 2 |
| Ghosh, S | 1 |
| Gal, J | 1 |
| Marczin, N | 1 |
| Siracusano, L | 1 |
| Girasole, V | 1 |
| Pang, Q | 1 |
| Dou, L | 1 |
| Pan, X | 1 |
| Zeng, S | 1 |
| He, J | 1 |
| Xu, W | 1 |
| Zeng, Y | 1 |
| Zhang, P | 1 |
| Zou, XQ | 1 |
| Shi, GS | 1 |
| Morimatsu, H | 1 |
| Takahashi, T | 1 |
| Matsusaki, T | 1 |
| Hayashi, M | 1 |
| Matsumi, J | 1 |
| Shimizu, H | 1 |
| Matsumi, M | 1 |
| Morita, K | 1 |
| Withers, CM | 2 |
| Bartz, RR | 2 |
| MacGarvey, NC | 2 |
| Fu, P | 2 |
| Sweeney, TE | 1 |
| Faller, S | 1 |
| Hoetzel, A | 3 |
| Gullotta, F | 1 |
| di Masi, A | 1 |
| Ascenzi, P | 1 |
| Morse, D | 1 |
| Rochette, L | 1 |
| Cottin, Y | 1 |
| Zeller, M | 1 |
| Vergely, C | 1 |
| Hanto, DW | 1 |
| Liu, DD | 1 |
| Gao, L | 1 |
| Szabo, G | 2 |
| Romics, L | 2 |
| Frendl, G | 2 |
| Iwasashi, H | 1 |
| Suzuki, M | 1 |
| Unno, M | 1 |
| Utiyama, T | 1 |
| Oikawa, M | 1 |
| Kondo, N | 1 |
| Matsuno, S | 1 |
| ILLINGWORTH, C | 1 |
| Doctor, A | 1 |
| Platt, R | 1 |
| Sheram, ML | 1 |
| Eischeid, A | 1 |
| McMahon, T | 1 |
| Maxey, T | 1 |
| Doherty, J | 1 |
| Axelrod, M | 1 |
| Kline, J | 1 |
| Gurka, M | 1 |
| Gow, A | 1 |
| Gaston, B | 1 |
| Akuta, T | 1 |
| Akaike, T | 1 |
| Schmidt, R | 2 |
| Scott, JR | 1 |
| Bilban, MH | 1 |
| Biswal, S | 1 |
| Remick, DG | 1 |
| Dolinay, T | 1 |
| Kaczorowski, DJ | 1 |
| Katada, K | 1 |
| Bihari, A | 1 |
| Macias, AA | 1 |
| Spapen, H | 1 |
| Rudinsky, BF | 1 |
| Lozon, M | 1 |
| Bell, A | 1 |
| Hipps, R | 1 |
| Meadow, WL | 1 |
| Downard, PJ | 1 |
| Wilson, MA | 1 |
| Spain, DA | 1 |
| Matheson, PJ | 1 |
| Siow, Y | 1 |
| Garrison, RN | 1 |
| Weisiger, RA | 1 |
| Zegdi, R | 1 |
| Perrin, D | 1 |
| Burdin, M | 1 |
| Boiteau, R | 1 |
| Tenaillon, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Value of ETCOc in the Diagnosis and Treatment of ABO Hemolytic Disease of the Newborn[NCT05842109] | 112 participants (Anticipated) | Observational | 2023-05-01 | Not yet recruiting | |||
| A Phase Ib Trial of Inhaled Carbon Monoxide for the Treatment of Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)[NCT04870125] | Phase 1 | 36 participants (Anticipated) | Interventional | 2023-12-06 | Recruiting | ||
| A Phase I Trial of Inhaled Carbon Monoxide for the Treatment of Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)[NCT02425579] | Phase 1 | 12 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| A Phase II Trial of Inhaled Carbon Monoxide for the Treatment of Acute Respiratory Distress Syndrome (ARDS)[NCT03799874] | Phase 2 | 32 participants (Anticipated) | Interventional | 2019-07-01 | Active, not recruiting | ||
| Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159] | Phase 2 | 140 participants (Actual) | Interventional | 2018-02-05 | Completed | ||
| A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001] | Phase 2 | 0 participants (Actual) | Interventional | 2013-10-31 | Withdrawn (stopped due to Sangart ceased operations) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Arm | 2.9 |
| Placebo Arm | 1.93 |
Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.
| Intervention | Days (Mean) |
|---|---|
| Treatment Arm | 11.5 |
| Placebo Arm | 11 |
In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Arm | 11 |
| Placebo Arm | 13 |
Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.
| Intervention | days (Mean) |
|---|---|
| Treatment Arm | 4.76 |
| Placebo Arm | 4.66 |
ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Arm | 6 |
| Placebo Arm | 10 |
PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization
| Intervention | Percent (Mean) |
|---|---|
| Treatment Arm | 63 |
| Placebo Arm | 58 |
Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.
| Intervention | hours (Mean) |
|---|---|
| HAT Treatment | 27 |
| Comparator | 53 |
Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization
| Intervention | Days (Mean) |
|---|---|
| Treatment Arm | 22 |
| Placebo Arm | 22.4 |
22 reviews available for carbon monoxide and Blood Poisoning
| Article | Year |
|---|---|
Application and value of hydrogen sulfide modulated autophagy in sepsis.
Topics: Autophagy; Carbon Monoxide; Humans; Hydrogen Sulfide; Nitric Oxide; Sepsis | 2023 |
Carbon monoxide in exhaled breath testing and therapeutics.
Topics: Acute Lung Injury; Anesthesia; Animals; Asthma; Biomarkers; Breath Tests; Carbon Monoxide; Cystic Fi | 2013 |
Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Gastrointestinal Diseases; Gastrointestinal Trac | 2013 |
Carbon monoxide in the treatment of sepsis.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Heme Oxygenase (Decyclizing); Humans; Inflammati | 2015 |
Pro-Resolving Molecules-New Approaches to Treat Sepsis?
Topics: Animals; Carbon Monoxide; Cytokines; Eicosanoids; Heme Oxygenase (Decyclizing); Humans; Oxidative St | 2017 |
Carbon monoxide releasing molecules: new insights for anticoagulation strategy in sepsis.
Topics: Anticoagulants; Blood Coagulation; Carbon Monoxide; Cell Adhesion Molecules; Cytokines; Humans; NF-k | 2009 |
Applying gases for microcirculatory and cellular oxygenation in sepsis: effects of nitric oxide, carbon monoxide, and hydrogen sulfide.
Topics: Animals; Carbon Monoxide; Hydrogen Sulfide; Microcirculation; Nitric Oxide; Nitric Oxide Synthase Ty | 2009 |
Carbon monoxide: endogenous mediator, potential diagnostic and therapeutic target.
Topics: Animals; Biomarkers; Carbon Monoxide; Cardiovascular Diseases; Exhalation; Gene Expression; Heme Oxy | 2010 |
Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Drug Design; E | 2010 |
Carbon monoxide in acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carbon Monoxide; Humans; Hyperoxia; Lung Trans | 2012 |
Carbon monoxide: an unusual drug.
Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Enzyme Induction; Heme Oxygenase-1; Humans; Infla | 2012 |
Carbon monoxide: mechanisms of action and potential clinical implications.
Topics: Animals; Carbon Monoxide; Cardiovascular Diseases; Endothelium, Vascular; Heme; Heme Oxygenase-1; Hu | 2013 |
The social network of carbon monoxide in medicine.
Topics: Carbon Monoxide; Heme Oxygenase-1; Humans; Immunity, Innate; Reperfusion Injury; Sepsis | 2013 |
Liver in sepsis and systemic inflammatory response syndrome.
Topics: Apoptosis; Carbon Monoxide; Cholestasis; Cytokines; Heat-Shock Proteins; Hemodynamics; Humans; Lipop | 2002 |
[Cellular and molecular changes of the liver in sepsis and in systemic inflammatory response syndrome (SIRS)].
Topics: Acute-Phase Proteins; Animals; Apoptosis; Carbon Monoxide; Cytokines; Heat-Shock Proteins; Humans; L | 2003 |
[Nitric oxide and its related compounds].
Topics: Asthma; Biomarkers; Carbon Monoxide; Chromatography, Gas; Chromatography, High Pressure Liquid; Clin | 2005 |
[Carbon monoxide--poison or potential therapeutic?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Atherosclerosis; Carbon Monoxide; | 2006 |
Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Humans; Lung Diseases; Oxidative Stress; Reperfu | 2007 |
Carbon monoxide in sepsis.
Topics: Anti-Inflammatory Agents; Apoptosis; Carbon Monoxide; Dose-Response Relationship, Drug; Forecasting; | 2007 |
Carbon monoxide: medicinal chemistry and biological effects.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Graft Rejection; Graft Survival; Heart Transplan | 2007 |
Liver perfusion in sepsis, septic shock, and multiorgan failure.
Topics: Animals; Carbon Monoxide; Endothelin-1; Humans; Liver; Liver Circulation; Microcirculation; Multiple | 2008 |
Carbon monoxide and sepsis: is a toxic gas good for your liver?
Topics: Carbon Monoxide; Humans; Liver; Sepsis | 2001 |
1 trial available for carbon monoxide and Blood Poisoning
| Article | Year |
|---|---|
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Topics: Administration, Inhalation; Adult; Aged; Biomarkers; Blood Gas Analysis; Carbon Monoxide; Carboxyhem | 2018 |
46 other studies available for carbon monoxide and Blood Poisoning
| Article | Year |
|---|---|
[Effects of carbon monoxide release molecule-2 on sepsis-induced myocardial dysfunction in rats].
Topics: Animals; Carbon Monoxide; Lipopolysaccharides; Male; Myocardium; Rats; Rats, Sprague-Dawley; Sepsis | 2019 |
Exogenous carbon monoxide suppresses LPS-Induced platelet SNAREs complex assembly and α-granule exocytosis via integrin αIIbβ3-Mediated PKCθ/Munc18a pathway.
Topics: Blood Platelets; Carbon Monoxide; Cytoplasmic Granules; Exocytosis; Gene Expression Regulation; Huma | 2020 |
Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Autophagosomes; Calcium; Carbon Monoxi | 2020 |
Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture.
Topics: Animals; Carbon Monoxide; Caspase 1; Cecum; Cytokines; Disease Models, Animal; Intestinal Mucosa; In | 2020 |
Clinical Factors Influencing Endogenous Carbon Monoxide Production and Carboxyhemoglobin Levels in Neonates.
Topics: Carbon Monoxide; Carboxyhemoglobin; Hemolysis; Humans; Infant, Newborn; Infant, Newborn, Diseases; O | 2022 |
The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide.
Topics: Actins; Animals; Carbon Monoxide; Cardiac Myosins; Cardiotonic Agents; Cell Line; Cytokines; Disease | 2018 |
Protective effects of carbon monoxide releasing molecule‑2 on pancreatic function in septic mice.
Topics: Animals; Biomarkers; Carbon Monoxide; Cytokines; Disease Models, Animal; Inflammation Mediators; Mic | 2019 |
Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carbon Monoxide; Cell Prolif | 2014 |
Resveratrol induces hepatic mitochondrial biogenesis through the sequential activation of nitric oxide and carbon monoxide production.
Topics: Animals; Antioxidants; Carbon Monoxide; Disease Models, Animal; Hep G2 Cells; Humans; Injections, In | 2014 |
Effect of carbon monoxide-releasing molecules II-liberated CO on suppressing inflammatory response in sepsis by interfering with nuclear factor kappa B activation.
Topics: Animals; Carbon Monoxide; Cell Adhesion; Human Umbilical Vein Endothelial Cells; Humans; Inflammatio | 2013 |
Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Carbon Monoxide; Cecum; F | 2014 |
A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway.
Topics: Adenosine Triphosphate; Animals; Carbon Monoxide; DNA-Binding Proteins; Energy Metabolism; Gene Expr | 2014 |
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Carbon Monoxide; Carrier Proteins; Cell | 2014 |
Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.
Topics: Animals; Biomarkers; Carbon Monoxide; Cytokines; Disease Models, Animal; Dose-Response Relationship, | 2014 |
IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production.
Topics: Animals; Carbon Monoxide; Cell Line; Gene Expression Regulation; Heme Oxygenase-1; Hydro-Lyases; Lip | 2016 |
Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.
Topics: Active Transport, Cell Nucleus; Animals; Ascorbic Acid; Carbon Monoxide; Cell Line; Cell Nucleus; Ch | 2015 |
Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carbon Monoxide; Cytokines; Female; Inflamm | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Anti-Bacterial Agents; Antioxidants; Carbon | 2015 |
Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blood Urea Nitrogen; Carbon Monoxide; Carrier Proteins; Cre | 2015 |
Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cells, Cultured; Cytokines; Disease Models, Anim | 2015 |
[Suppressive effect of exogenous carbon monoxide on abnormal platelet exocytosis and its molecular mechanism in sepsis].
Topics: Becaplermin; Blood Platelets; Carbon Monoxide; Exocytosis; Humans; Isoenzymes; Lipopolysaccharides; | 2016 |
Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2.
Topics: Animals; Carbon Monoxide; G-Protein-Coupled Receptor Kinase 2; Lipopolysaccharides; Mice; Mice, Inbr | 2016 |
Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.
Topics: Animals; Carbon Monoxide; Lipids; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mic | 2016 |
Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Enzyme-Linked Immuno | 2017 |
Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Male; Membr | 2009 |
What's new in Shock, May 2009?
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Humans; Sepsis; Shock | 2009 |
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.
Topics: Active Transport, Cell Nucleus; Animals; Carbon Monoxide; Cells, Cultured; Cyclooxygenase 2; Cytokin | 2009 |
CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase.
Topics: Animals; Carbon Monoxide; Cell Adhesion; Cell Migration Assays, Leukocyte; Cell Movement; Cells, Cul | 2009 |
Carbon monoxide and adiponectin in sepsis.
Topics: Adiponectin; Animals; Carbon Monoxide; Heme Oxygenase-1; Mice; Mice, Knockout; Sepsis | 2010 |
Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators.
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Cecum; Cytoprotection; Disease Models, Animal; Disulfir | 2010 |
[Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on the activation of Janus kinase/signal transducer and activator of transcription pathway in sepsis].
Topics: Animals; Carbon Monoxide; Cells, Cultured; Interleukin-1beta; Janus Kinase 1; Janus Kinase 3; Male; | 2010 |
An increase in exhaled CO concentration in systemic inflammation/sepsis.
Topics: Anesthesia; Biomarkers; Breath Tests; Carbon Monoxide; Critical Illness; Exhalation; Heme Oxygenase- | 2010 |
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.
Topics: Animals; Carbon Monoxide; Cytokines; Gene Expression Regulation; Heme Oxygenase-1; Hep G2 Cells; Hum | 2011 |
Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis.
Topics: Administration, Inhalation; Animals; Blotting, Western; Carbon Monoxide; Disease Models, Animal; Fem | 2012 |
Carbon monoxide, a modern "pharmakon" for sepsis.
Topics: Animals; Carbon Monoxide; Female; Heme Oxygenase-1; Male; Mitochondria; NF-E2-Related Factor 2; Seps | 2012 |
Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice.
Topics: Animals; Caco-2 Cells; Carbon Monoxide; Disease Models, Animal; Enteritis; Humans; Ileitis; Inflamma | 2012 |
Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); L | 2003 |
THE LISTER LECTURE, 1964: WOUND SEPSIS-FROM CARBOLIC ACID TO HYPERBARIC OXYGEN.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Asphyxia Neonatorum; Carbon Monoxide; Cerebrova | 1964 |
Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients.
Topics: Animals; Biological Assay; Carbon Monoxide; Copper; Erythrocytes; Fluorescent Dyes; Hemoglobins; Hum | 2005 |
Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic?
Topics: Atherosclerosis; Bilirubin; Biliverdine; Carbon Monoxide; Cytoprotection; Heme Oxygenase-1; Homeosta | 2007 |
Sepsis: redox mechanisms and therapeutic opportunities.
Topics: Animals; Carbon Monoxide; Humans; Oxidation-Reduction; Reactive Oxygen Species; Respiration, Artific | 2007 |
Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Monoxide; Cecum; Cell Adhesion; Cells, Cultured; Disease M | 2008 |
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.
Topics: Animals; Antimetabolites; Carbon Monoxide; Enterococcus faecalis; Escherichia coli; Escherichia coli | 2008 |
Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets.
Topics: Animals; Blood Pressure; Brain; Carbon Monoxide; Carotid Artery, Internal; Disease Models, Animal; H | 1996 |
Heme oxygenase-dependent carbon monoxide production is a hepatic adaptive response to sepsis.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Enzyme Induction; Heme Oxygenase (Decyclizing); Liver; Male; M | 1997 |
Increased endogenous carbon monoxide production in severe sepsis.
Topics: Aged; Analysis of Variance; APACHE; Breath Tests; Carbon Monoxide; Case-Control Studies; Comorbidity | 2002 |