carbon monoxide and Anemia studies

Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.

Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.

Research Excerpts

Excerpt	Relevance	Reference
"Low arginine, low nitric oxide production, and endothelial dysfunction are common in severe malaria."	8.84	Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. ( Granger, DL; Lopansri, BK; Mwaikambo, E; Weinberg, JB, 2008)
"Low arginine, low nitric oxide production, and endothelial dysfunction are common in severe malaria."	4.84	Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. ( Granger, DL; Lopansri, BK; Mwaikambo, E; Weinberg, JB, 2008)
" Alternative experimental strategies to reduce oxygen delivery, including breathing carbon monoxide (600 ppm in air) or severe anemia, can reverse neurological disease."	3.91	Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. ( Ast, T; Brepoels, K; Carmeliet, P; Galkin, A; Goldberger, O; Ichinose, F; Jain, IH; Marutani, E; Mootha, VK; Schleifer, G; Schoonjans, L; Stepanova, A; Wang, H; Wojtkiewicz, GR; Zapol, WM; Zazzeron, L, 2019)
"To evaluate the effect of breathing 50 ppm carbon monoxide (CO) on exercise capacity in persons with anemia, 10 nonsmoking subjects with chronic anemia (mean hemoglobin 8."	3.67	Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin. ( Aronow, WS; Petratis, M; Schlueter, WJ; Sketch, MH; Williams, MA, 1984)
" An increase of DLCO for 20% of predicted normal at decreasing apnea time (tA = 5 sec) resulted from an increased pulmonary capillary blood volume for 50--90% of the predicted value (at tA = 10 sec), whereas membrane diffusing capacity remained unchanged over the range of apnea times."	3.66	Effects of abnormal hemoglobin concentration in human blood on membrane diffusing capacity of the lung and on pulmonary capillary blood volume. ( Riepl, G, 1978)
"The rate of endogenous carbon monoxide production ( Vco), determined by the closed rebreathing system technique, was elevated above the normal range in four of five patients studied with ineffective erythropoiesis (four patients with primary refractory anemia, one with thalassemia)."	3.64	Carbon monoxide production associated with ineffective erythropoiesis. ( Coburn, RF; Goldwein, MI; Rother, ML; Shafer, BC; White, P; Williams, WJ, 1967)
"In the patients with interstitial pulmonary fibrosis, the influence of the reduced diffusing capacity of the alveolocapillary membrane on the extent of the diffusion disorder was in each case greater than the effects due to the anemia."	1.27	Effect of low hemoglobin levels on the diffusing capacity of the lungs for CO. Investigations in persons with healthy lungs and in patients with interstitial pulmonary fibrosis. ( Petermann, W, 1985)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (72.55)	18.7374
1990's	2 (3.92)	18.2507
2000's	5 (9.80)	29.6817
2010's	6 (11.76)	24.3611
2020's	1 (1.96)	2.80

Authors	Studies
Jain, IH	1
Zazzeron, L	1
Goldberger, O	1
Marutani, E	1
Wojtkiewicz, GR	1
Ast, T	1
Wang, H	1
Schleifer, G	1
Stepanova, A	1
Brepoels, K	1
Schoonjans, L	1
Carmeliet, P	1
Galkin, A	1
Ichinose, F	1
Zapol, WM	1
Mootha, VK	1
Bomholt, T	1
Larsson, S	1
Rix, M	1
Rytter, S	1
Feldt-Rasmussen, B	1
Hornum, M	1
Lundby, C	1
Abuchowski, A	1
Nitta, S	1
Kawai, K	1
Nagumo, Y	1
Ikeda, A	1
Kandori, S	1
Kojima, T	1
Nishiyama, H	1
Weinberg, JB	1
Lopansri, BK	1
Mwaikambo, E	1
Granger, DL	1
Franco, RS	1
Johnson, DC	1
Bruce, EN	1
Bruce, MC	1
Erupaka-Chada, K	1
Sato, Y	1
Mizuguchi, T	1
Shigenaga, S	1
Yoshikawa, E	1
Chujo, K	1
Minakuchi, J	1
Kawashima, S	1
PECORA, L	1
FATI, S	1
VECCHIONE, C	1
RANKIN, J	1
McNEILL, RS	1
FORSTER, RE	1
ENGSTEDT, L	1
PERIC, B	1
TRIBUKAIT, B	1
SIRS, JA	1
PURUGGANAN, HB	1
MCELFRESH, AE	1
WALLER, HD	2
STAHL, W	2
LEE, GR	1
HAUT, A	1
CAINE, TH	1
CARTWRIGHT, GE	1
WINTROBE, MM	1
STOKES, GS	1
KORNER, PI	1
CARLOS, AG	1
SOARES, AD	1
PALMACARLOS, AG	1
PALMACARLOS, ML	1
DUCLASOARES, A	1
BEUTLER, E	1
BALUDA, M	1
DONNELL, GN	1
CAHILL, JM	1
JOUASSET-STRIEDER, D	1
BYRNE, JJ	1
HALLBERG, L	1
FLEISCHHACKER, HH	1
LINDSAY, CS	1
CROIZAT, P	1
REVOL, L	1
FAVRE-GILLY, J	1
Mitlyng, BL	1
Singh, JA	1
Furne, JK	1
Ruddy, J	1
Levitt, MD	1
Leifert, JA	1
Mulhausen, R	1
Astrup, P	1
Kjeldsen, K	1
White, P	1
Coburn, RF	3
Williams, WJ	1
Goldwein, MI	1
Rother, ML	1
Shafer, BC	1
Jones, MD	1
Traystman, RJ	1
Aronow, WS	1
Schlueter, WJ	1
Williams, MA	1
Petratis, M	1
Sketch, MH	1
Marrades, RM	1
Diaz, O	1
Roca, J	1
Campistol, JM	1
Torregrosa, JV	1
Barberà, JA	1
Cobos, A	1
Félez, MA	1
Rodriguez-Roisin, R	1
Hofbauer, KH	1
Jensen, BL	1
Kurtz, A	2
Sandner, P	1
Riepl, G	1
Goldbaum, LR	1
Ramirez, RG	1
Absalon, KB	1
Cavallin-Ståhl, E	2
Mercke, C	2
Lundh, B	2
Eckardt, KU	1
LeHir, M	1
Tan, CC	1
Ratcliffe, PJ	1
Kaissling, B	1
Johansson, MB	1
Wollmer, P	1
Petermann, W	1
Syvertsen, GR	1
Harris, JA	1
Lewis, SM	2
Verwilghen, RI	1
Pettit, JE	1
Williams, ED	1
Glass, HI	1
Szur, L	1
Wicks, CJ	1
Ramsey, JM	1
Lawson, WH	1
Hilpert, P	1
Brody, JS	1
Landaw, SA	1
Winchell, HS	1
Sundström, G	1
Liljedahl, SO	1
Reizenstein, P	1
Asén, P	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Assessment of Regional Lung Ventilation Distribution During Supraglottic and Subglottic Jet Ventilation by Electrical Impedance Tomography (EIT).[NCT03973294]				30 participants (Actual)	Interventional	2019-06-07	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. Current opinion in infectious diseases, 2008, Volume: 21, Issue:5 Topics: Anemia; Animals; Arginine; Biological Availability; Carbon Monoxide; Endothelium, Vascular; Humans;	2008
The measurement and importance of red cell survival. American journal of hematology, 2009, Volume: 84, Issue:2 Topics: Anemia; Animals; Biotinylation; Breath Tests; Carbon Monoxide; Chromium Isotopes; Chromium Radioisot	2009
Anaemia and cigarette smoking. International journal of laboratory hematology, 2008, Volume: 30, Issue:3 Topics: Anemia; Carbon Monoxide; Carboxyhemoglobin; Humans; Smoking	2008
Cerebral oxygenation of the fetus, newborn, and adult. Seminars in perinatology, 1984, Volume: 8, Issue:3 Topics: Adult; Age Factors; Anemia; Animals; Animals, Newborn; Brain; Carbon Dioxide; Carbon Monoxide; Cattl	1984
Endogenous carbon monoxide production. The New England journal of medicine, 1970, Jan-22, Volume: 282, Issue:4 Topics: Anemia; Animals; Bilirubin; Carbon Isotopes; Carbon Monoxide; Dogs; Erythrocytes; Glycine; Heme; Hem	1970

Article	Year
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell metabolism, 2019, 10-01, Volume: 30, Issue:4 Topics: Anemia; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Carbon Monoxide; Disease Model	2019
Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis. Hemodialysis international. International Symposium on Home Hemodialysis, 2020, Volume: 24, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Carbon Monoxide; Female; Humans; Male; Middle Ag	2020
SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update. Artificial organs, 2017, Volume: 41, Issue:4 Topics: Anemia; Anemia, Sickle Cell; Animals; Blood Substitutes; Brain Ischemia; Carbon Monoxide; Carboxyhem	2017
Impact of hemoglobin levels on hemoglobin-adjusted carbon monoxide diffusion capacity after chemotherapy for testicular cancer. Japanese journal of clinical oncology, 2019, Dec-27, Volume: 49, Issue:12 Topics: Adolescent; Adult; Anemia; Antibiotics, Antineoplastic; Bleomycin; Carbon Monoxide; Chemotherapy, Ad	2019
Correct diffusing capacity of lung for carbon monoxide and carbon monoxide transfer coefficient in considering respiratory function in patients with stable anorexia nervosa. Chest, 2010, Volume: 137, Issue:5 Topics: Anemia; Anorexia Nervosa; Carbon Monoxide; Hematocrit; Humans; Lung; Lung Volume Measurements; Organ	2010
A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:2 Topics: Adult; Anemia; Biomass; Carbon Monoxide; Carboxyhemoglobin; Cardiac Output; Cooking; Environmental E	2011
Shortened red blood cell lifespan is related to the dose of erythropoiesis-stimulating agents requirement in patients on hemodialysis. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2012, Volume: 16, Issue:6 Topics: Aged; Anemia; Carbon Monoxide; Case-Control Studies; Dose-Response Relationship, Drug; Erythrocyte A	2012
[Hypersideremic hypochromic anemia during carbon monoxide poisoning]. Le Sang, 1958, Volume: 29, Issue:6 Topics: Anemia; Anemia, Hypochromic; Anemia, Sideroblastic; Carbon Monoxide; Carbon Monoxide Poisoning; Gene	1958
The effect of anemia on the alveolar-capillary exchange of carbon monoxide in man. The Journal of clinical investigation, 1961, Volume: 40 Topics: Anemia; Capillaries; Carbon Monoxide; Cardiovascular System; Humans; Male	1961
[Hemoglobin content and blood volume of normal, anemic and polycythemic rats, determined by carbon monoxide and radiochromium]. Acta physiologica Scandinavica, 1960, Jul-15, Volume: 49 Topics: Anemia; Animals; Blood Volume; Carbon Monoxide; Hemoglobins; Polycythemia; Rats	1960
The use of carbon monoxide to prevent sickle-cell formation. Lancet (London, England), 1963, May-04, Volume: 1, Issue:7288 Topics: Anemia; Anemia, Sickle Cell; Carbon Monoxide	1963
FAILURE OF CARBONMONOXY SICKLE-CELL HAEMOGLOBIN TO ALTER THE SICKLE STATE. Lancet (London, England), 1964, Jan-11, Volume: 1, Issue:7324 Topics: Anemia; Anemia, Sickle Cell; Blood Gas Analysis; Carbon Monoxide; Child; Hemoglobin, Sickle; Hemoglo	1964
[THE TOTAL HEMOGLOBIN (HBT) CONTENT IN CHRONIC KIDNEY DISEASES (RESULTS WITH A NEW CO INHALATION METHOD)]. Medizinische Klinik, 1963, Dec-27, Volume: 58 Topics: Anemia; Carbon Monoxide; Glomerulonephritis; Hemoglobinometry; Hemoglobins; Humans; Kidney Diseases;	1963
THE CHROMATOGRAPHY OF HEMINS FROM NORMAL AND ABNORMAL HUMAN ERYTHROCYTES. Blood, 1964, Volume: 23 Topics: Acetone; Acid-Base Equilibrium; Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Carbon Monoxide; Chr	1964
EFFECT OF POSTHEMORRHAGIC ANEMIA ON THE RENAL CIRCULATION OF THE UNANESTHETIZED RABBIT. Circulation research, 1964, Volume: 14 Topics: Anemia; Animals; Blood Circulation; Blood Gas Analysis; Blood Viscosity; Blood Volume; Carbon Monoxi	1964
[THE VALUE OF TOTAL HEMOGLOBIN (HBT) DETERMINATION FOR THE EVALUATION OF THE COURSE OF HEMATOLOGIC DISEASES]. Deutsche medizinische Wochenschrift (1946), 1963, Dec-06, Volume: 88 Topics: Anemia; Anemia, Hypochromic; Anemia, Pernicious; Carbon Monoxide; Hematologic Diseases; Hemoglobinom	1963
[THE ENDOGENOUS PRODUCTION OF CARBON MONOXIDE AS AN INDEX OF HEMOGLOBIN CATABOLISM]. Jornal do medico, 1964, Jul-18, Volume: 54 Topics: Anemia; Carbon Monoxide; Hemoglobins; Leukemia; Metabolism; Polycythemia; Spherocytosis, Hereditary	1964
[THE STUDY OF SERUM CO CONCENTRATION IN SOME HEMOPATHIES]. Sangre, 1964, Volume: 10 Topics: Anemia; Blood; Carbon Monoxide; Hematologic Diseases; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Hu	1964
A NEW METHOD FOR THE DETECTION OF GALACTOXEMIA AND ITS CARRIER STATE. The Journal of laboratory and clinical medicine, 1964, Volume: 64 Topics: Anemia; Biomedical Research; Blood Chemical Analysis; Carbon Monoxide; Carrier State; Citrates; Colo	1964
LUNG FUNCTION IN SHOCK. American journal of surgery, 1965, Volume: 110 Topics: Anemia; Animals; Blood Pressure; Blood Volume; Capillaries; Carbon Monoxide; Dogs; Endotoxins; Eryth	1965
Blood volume, hemolysis and regeneration of blood in pernicious anemia; studies based on the endogenous formation of carbon monoxide and determinations of the total amount of hemoglobin. Scandinavian journal of clinical and laboratory investigation, 1955, Volume: 7 Suppl. 16 Topics: Anemia; Anemia, Pernicious; Blood Volume; Carbon Monoxide; Erythrocytes; Hemoglobins; Hemolysis; Reg	1955
Coal-gas poisoning in patient suffering from pernicious anaemia. British medical journal, 1951, Feb-17, Volume: 1, Issue:4702 Topics: Anemia; Anemia, Pernicious; Carbon Monoxide; Coal; Gas Poisoning; Humans	1951
[Aplastic anemia caused by carbon monoxide poisoning]. Archives des maladies professionnelles de medecine du travail et de securite sociale, 1952, Volume: 13, Issue:2 Topics: Anemia; Anemia, Aplastic; Carbon Monoxide; Carbon Monoxide Poisoning; Tracheophyta	1952
Oxygen affinity of hemoglobin in patients with cardiovascular diseases, anemia, and cirrhosis of the liver. Scandinavian journal of clinical and laboratory investigation, 1967, Volume: 19, Issue:3 Topics: Anemia; Carbon Monoxide; Cardiovascular Diseases; Hemoglobins; Humans; Hydrogen-Ion Concentration; L	1967
Carbon monoxide production associated with ineffective erythropoiesis. The Journal of clinical investigation, 1967, Volume: 46, Issue:12 Topics: Adolescent; Adult; Aged; Anemia; Anemia, Sideroblastic; Bile Pigments; Bilirubin; Carbon Isotopes; C	1967
Aggravation of exercise performance in patients with anemia by 3% carboxyhemoglobin. Environmental research, 1984, Volume: 35, Issue:2 Topics: Aged; Anemia; Blood Pressure; Carbon Monoxide; Carboxyhemoglobin; Double-Blind Method; Female; Heart	1984
Adjustment of DLCO for hemoglobin concentration. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:1 Topics: Adult; Aged; Anemia; Carbon Monoxide; Erythropoietin; Female; Hemoglobins; Humans; Kidney Failure, C	1997
Tissue hypoxygenation activates the adrenomedullin system in vivo. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:2 Topics: Administration, Inhalation; Adrenomedullin; Anemia; Animals; Carbon Monoxide; Hypoxia; Male; Membran	2000
Effects of abnormal hemoglobin concentration in human blood on membrane diffusing capacity of the lung and on pulmonary capillary blood volume. Respiration; international review of thoracic diseases, 1978, Volume: 36, Issue:1 Topics: Anemia; Apnea; Capillaries; Carbon Monoxide; Hemoglobins; Humans; Male; Polycythemia; Pulmonary Circ	1978
What is the mechanism of carbon monoxide toxicity? Aviation, space, and environmental medicine, 1975, Volume: 46, Issue:10 Topics: Aerospace Medicine; Anemia; Animals; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin;	1975
Carbon monoxide production in patients with breast carcinoma. British journal of haematology, 1976, Volume: 32, Issue:2 Topics: Adult; Aged; Anemia; Breast Neoplasms; Carbon Monoxide; Erythrocyte Aging; Erythropoiesis; Female; H	1976
Erythropoiesis and carbon monoxide production in Hodgkin's disease. British journal of haematology, 1976, Volume: 32, Issue:2 Topics: Adolescent; Adult; Aged; Anemia; Bone Marrow Examination; Carbon Monoxide; Erythrocyte Aging; Erythr	1976
Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels. The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 2 Topics: Anemia; Animals; Blood Pressure; Carbon Monoxide; Cell Hypoxia; Denervation; Erythropoietin; Hematoc	1992
Measurement of carboxyhaemoglobin by spectrophotometry and gas chromatography. Clinical physiology (Oxford, England), 1989, Volume: 9, Issue:6 Topics: Anemia; Carbon Monoxide; Carboxyhemoglobin; Chromatography, Gas; Humans; Reference Standards; Reprod	1989
Effect of low hemoglobin levels on the diffusing capacity of the lungs for CO. Investigations in persons with healthy lungs and in patients with interstitial pulmonary fibrosis. Respiration; international review of thoracic diseases, 1985, Volume: 47, Issue:1 Topics: Adult; Aged; Anemia; Carbon Monoxide; Female; Hemoglobins; Humans; Male; Middle Aged; Pulmonary Diff	1985
Erythropoietin production in dogs exposed to high altitude and carbon monoxide. The American journal of physiology, 1973, Volume: 225, Issue:2 Topics: Altitude; Anemia; Animals; Biological Assay; Carbon Monoxide; Dogs; Erythropoiesis; Erythropoietin;	1973
Dyserythropoiesis and dyserythropoietic anemias. Progress in hematology, 1973, Volume: 8 Topics: Anemia; Anemia, Aplastic; Anemia, Hypochromic; Antibodies; Blood Cell Count; Bone Marrow Cells; Carb	1973
Studies of splenic function in the myeloproliferative disorders and generalized malignant lymphomas. British journal of haematology, 1971, Volume: 20, Issue:6 Topics: Adolescent; Adult; Aged; Anemia; Anemia, Hemolytic, Autoimmune; Blood Platelets; Carbon Isotopes; Ca	1971
Carbon monoxide, tissue hypoxia, and sensory psychomotor response in hypoxaemic subjects. Clinical science, 1972, Volume: 42, Issue:5 Topics: Anemia; Arteries; Carbon Monoxide; Carbon Monoxide Poisoning; Depth Perception; Emphysema; Hematocri	1972
Effect of anemia, species, and temperature on CO kinetics with red blood cells. Journal of applied physiology, 1971, Volume: 31, Issue:3 Topics: Anemia; Anemia, Hypochromic; Anemia, Sickle Cell; Animals; Blood Volume; Capillary Permeability; Car	1971
[Variation of the carbon monoxide diffusing capacity of the lung with the hemoglobin concentration of the blood]. Respiration; international review of thoracic diseases, 1971, Volume: 28, Issue:6 Topics: Adult; Aged; Anemia; Capillary Resistance; Carbon Monoxide; Female; Hematocrit; Hemoglobinometry; He	1971
Effects of elevated carboxyhemoglobin on gas exchange in the lung. Annals of the New York Academy of Sciences, 1970, Oct-05, Volume: 174, Issue:1 Topics: Anemia; Carbon Monoxide; Carbon Monoxide Poisoning; Hemoglobins; Hydrogen-Ion Concentration; Hypoxia	1970
Endogenous production of 14CO: A method for calculation of RBC life-span in vivo. Blood, 1970, Volume: 36, Issue:5 Topics: Anemia; Anemia, Hypochromic; Animals; Carbon Isotopes; Carbon Monoxide; Erythrocyte Aging; Erythrocy	1970
[Simple COHb method in the hemolytic state]. Nordisk medicin, 1970, Nov-19, Volume: 84, Issue:47 Topics: Anemia; Anemia, Macrocytic; Carbon Monoxide; Hemoglobins; Humans	1970
Studies on trauma. 3. Plasma iron elimination rate. Acta chirurgica Scandinavica, 1969, Volume: 135, Issue:4 Topics: Anemia; Bilirubin; Blood Sedimentation; Bloodletting; Carbon Monoxide; Cortisone; Female; Hemoglobin	1969

carbon monoxide and Anemia

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