carbon monoxide has been researched along with Anemia, Sickle Cell in 50 studies
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Excerpt | Relevance | Reference |
---|---|---|
"Carbon monoxide (CO) production from heme catabolism is increased with hemolysis." | 7.81 | Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia. ( Goldrich, A; Lal, A; Marsh, A; Patterson, L, 2015) |
"In this study, the authors examined a possible role of measurements of end-tidal carbon monoxide (CO), corrected for inhaled CO (ETCOc), as a noninvasive screening tool for hemoglobinopathies and as an indicator for when transfusions would be required in patients receiving chronic transfusions." | 7.76 | Elevated exhaled carbon monoxide concentration in hemoglobinopathies and its relation to red blood cell transfusion therapy. ( Golden, DW; Hall, JY; Harmatz, P; James, EB; Schumacher, L; Simon, J; Stevenson, DK; Vichinsky, E; Vreman, HJ; Wong, RJ, 2010) |
"Carbon monoxide (CO) has anti-inflammatory properties." | 5.35 | Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. ( Beckman, JD; Belcher, JD; Chen, C; Gulbahce, E; Hebbel, RP; Nguyen, J; Nwaneri, MO; O'Sullivan, MG; Vercellotti, GM; Vineyard, JV, 2009) |
"Carbon monoxide (CO) production from heme catabolism is increased with hemolysis." | 3.81 | Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia. ( Goldrich, A; Lal, A; Marsh, A; Patterson, L, 2015) |
"In this study, the authors examined a possible role of measurements of end-tidal carbon monoxide (CO), corrected for inhaled CO (ETCOc), as a noninvasive screening tool for hemoglobinopathies and as an indicator for when transfusions would be required in patients receiving chronic transfusions." | 3.76 | Elevated exhaled carbon monoxide concentration in hemoglobinopathies and its relation to red blood cell transfusion therapy. ( Golden, DW; Hall, JY; Harmatz, P; James, EB; Schumacher, L; Simon, J; Stevenson, DK; Vichinsky, E; Vreman, HJ; Wong, RJ, 2010) |
"A hemolysis-linked subphenotype of sickle cell disease (SCD), characterized by pulmonary hypertension, stroke, priapism and leg ulcers, is associated with decreased nitric oxide bioavailability and vasculopathy." | 1.35 | Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I. ( Kato, GJ, 2008) |
"Carbon monoxide (CO) has anti-inflammatory properties." | 1.35 | Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. ( Beckman, JD; Belcher, JD; Chen, C; Gulbahce, E; Hebbel, RP; Nguyen, J; Nwaneri, MO; O'Sullivan, MG; Vercellotti, GM; Vineyard, JV, 2009) |
"Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have been reported." | 1.33 | Abnormal pulmonary function in adults with sickle cell anemia. ( Klings, ES; Nolan, VG; Steinberg, MH; Wyszynski, DF, 2006) |
"A young women with sickle cell anemia was admitted with a typical painful crisis, and was found to have a PCV of 39% with a reticulocyte count of 3." | 1.26 | Increased blood viscosity in a patient with sickle cell anemia. ( Charache, S; de la Monte, S; MacDonald, V, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 25 (50.00) | 18.7374 |
1990's | 3 (6.00) | 18.2507 |
2000's | 8 (16.00) | 29.6817 |
2010's | 13 (26.00) | 24.3611 |
2020's | 1 (2.00) | 2.80 |
Authors | Studies |
---|---|
van Vuren, AJ | 1 |
Minniti, CP | 1 |
Mendelsohn, L | 1 |
Baird, JH | 1 |
Kato, GJ | 2 |
van Beers, EJ | 1 |
Gomperts, E | 2 |
Belcher, JD | 5 |
Otterbein, LE | 3 |
Coates, TD | 1 |
Wood, J | 1 |
Skolnick, BE | 1 |
Levy, H | 2 |
Vercellotti, GM | 5 |
Abuchowski, A | 1 |
Chen, C | 4 |
Nguyen, J | 4 |
Abdulla, F | 2 |
Zhang, P | 1 |
Nguyen, H | 1 |
Nguyen, P | 1 |
Killeen, T | 1 |
Miescher, SM | 1 |
Brinkman, N | 1 |
Nath, KA | 1 |
Steer, CJ | 1 |
Tackett, AP | 1 |
Leavens, ELS | 1 |
Wiedenmann, A | 1 |
Perez, MN | 1 |
Baker, A | 1 |
Mayes, S | 1 |
Mullins, LL | 1 |
Wagener, TL | 1 |
Kiser, ZM | 1 |
Gallo, D | 1 |
Al-Khabori, M | 1 |
Al-Hashim, A | 1 |
Jabeen, Z | 1 |
Al-Farsi, K | 1 |
Al-Huneini, M | 1 |
Al-Riyami, A | 1 |
Al-Kemyani, N | 1 |
Daar, S | 1 |
Young, M | 1 |
Burhop, K | 1 |
Tran, P | 1 |
Araujo, JA | 1 |
Mekontso Dessap, A | 1 |
Contou, D | 1 |
Dandine-Roulland, C | 1 |
Hemery, F | 1 |
Habibi, A | 1 |
Charles-Nelson, A | 1 |
Galacteros, F | 1 |
Brun-Buisson, C | 1 |
Maitre, B | 1 |
Katsahian, S | 1 |
Lal, A | 1 |
Patterson, L | 1 |
Goldrich, A | 1 |
Marsh, A | 1 |
Lunt, A | 1 |
McGhee, E | 1 |
Robinson, P | 1 |
Rees, D | 2 |
Height, S | 1 |
Greenough, A | 3 |
Beckman, JD | 1 |
Vineyard, JV | 1 |
Nwaneri, MO | 1 |
O'Sullivan, MG | 1 |
Gulbahce, E | 1 |
Hebbel, RP | 1 |
Vandorpe, DH | 1 |
Xu, C | 1 |
Shmukler, BE | 1 |
Trudel, M | 1 |
Sachs, F | 1 |
Gottlieb, PA | 1 |
Brugnara, C | 1 |
Alper, SL | 1 |
James, EB | 1 |
Vreman, HJ | 1 |
Wong, RJ | 1 |
Stevenson, DK | 1 |
Vichinsky, E | 1 |
Schumacher, L | 1 |
Hall, JY | 1 |
Simon, J | 1 |
Golden, DW | 1 |
Harmatz, P | 1 |
SIRS, JA | 1 |
PURUGGANAN, HB | 1 |
MCELFRESH, AE | 1 |
Sylvester, KP | 2 |
Patey, RA | 1 |
Rafferty, GF | 1 |
Thein, SL | 3 |
Klings, ES | 1 |
Wyszynski, DF | 1 |
Nolan, VG | 1 |
Steinberg, MH | 1 |
Desai, SR | 1 |
Wells, AU | 1 |
Hansell, DM | 1 |
Awogbade, M | 1 |
O'Malley, GF | 1 |
Yallop, D | 1 |
Duncan, ER | 1 |
Norris, E | 1 |
Fuller, GW | 1 |
Thomas, N | 1 |
Walters, J | 1 |
Dick, MC | 1 |
Height, SE | 1 |
Rees, DC | 1 |
Adachi, K | 1 |
Kinney, TR | 1 |
Schwartz, E | 1 |
Asakura, T | 1 |
Charache, S | 1 |
de la Monte, S | 1 |
MacDonald, V | 1 |
Antonini, E | 3 |
Brunori, M | 3 |
Giardina, B | 3 |
Benedetti, PA | 3 |
Grassi, S | 3 |
Gualtieri, P | 1 |
Shapiro, DB | 1 |
Esquerra, RM | 1 |
Goldbeck, RA | 1 |
Ballas, SK | 2 |
Mohandas, N | 1 |
Kliger, DS | 1 |
Louderback, JG | 1 |
Aroutiounian, SK | 1 |
Kerr, WC | 1 |
Kim-Shapiro, DB | 1 |
Kiessling, K | 1 |
Roberts, N | 1 |
Gibson, JS | 1 |
Ellory, JC | 1 |
Beutler, E | 1 |
Bianchini, G | 2 |
Miller, GJ | 2 |
Serjeant, GR | 2 |
Saunders, MJ | 1 |
Richardson, C | 1 |
Gilson, RJ | 1 |
Milosz, A | 1 |
Settle, W | 1 |
Ogawa, E | 1 |
Hasegawa, M | 1 |
Fujise, H | 1 |
Kobayashi, K | 1 |
Solanki, DL | 1 |
McCurdy, PR | 2 |
Cuttitta, FF | 1 |
Schechter, GP | 1 |
Mozzarelli, A | 1 |
Hofrichter, J | 1 |
Eaton, WA | 1 |
Slovis, CM | 1 |
Talley, JD | 1 |
Pitts, RB | 1 |
Rodgers, GP | 1 |
Noguchi, CT | 1 |
Schechter, AN | 1 |
Pimstone, NR | 1 |
Bensinger, TA | 3 |
Gillette, PN | 1 |
Glader, BE | 1 |
Conrad, ME | 2 |
Moon, RB | 1 |
Nelson, MJ | 1 |
Richards, JH | 1 |
Powars, DF | 1 |
Bunn, HF | 2 |
McDonough, M | 1 |
Segel, GB | 1 |
Feig, SA | 1 |
Mentzer, WC | 1 |
McCaffrey, RP | 1 |
Wells, R | 1 |
Shohet, SB | 1 |
Nathan, DG | 1 |
Maisels, MJ | 1 |
Mahmood, L | 1 |
Engel, RR | 1 |
Rodkey, FL | 1 |
Krill, CE | 1 |
Lawson, WH | 1 |
Femi-Pearse, D | 1 |
Gazioglu, KM | 1 |
Yu, PN | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
End-Alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease[NCT01547793] | 106 participants (Actual) | Observational | 2012-01-26 | Completed | |||
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients With Sickle Cell Anemia[NCT00011648] | 986 participants (Actual) | Observational | 2008-02-19 | Completed | |||
Impact of E-cigarette Nicotine Concentration on Compensation, Cigarette Smoking, and Biomarkers of Exposure and Harm in Diverse Smokers[NCT05887947] | 48 participants (Anticipated) | Interventional | 2023-02-20 | Recruiting | |||
A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001] | Phase 2 | 0 participants (Actual) | Interventional | 2013-10-31 | Withdrawn (stopped due to Sangart ceased operations) | ||
Point-of-Care End-Tidal Carbon Monoxide Measurement to Screen for Sickle Cell Disease[NCT02530242] | 32 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
Aerobic Physical Fitness and Health-related Quality of Life in Children With Sickle Cell Disease.[NCT05995743] | 72 participants (Actual) | Observational | 2021-11-01 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Compare ETCO between subjects and controls (NCT02530242)
Timeframe: 1 hour
Intervention | ppm (Median) |
---|---|
End-tidal Carbon Monoxide Subjects | 4.35 |
End-tidal Carbon Monoxide Controls | .80 |
3 reviews available for carbon monoxide and Anemia, Sickle Cell
Article | Year |
---|---|
The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Clinical Trials as Topic; Disease Models, Animal; Hem | 2017 |
Renal degradation of hemoglobin.
Topics: Amino Acids; Anemia, Hemolytic; Anemia, Sickle Cell; Animals; Bilirubin; Carbon Isotopes; Carbon Mon | 1972 |
Hemolysis in sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Carbon Monoxide; Carbon Radioisotopes; Child; Chromium Radio | 1974 |
1 trial available for carbon monoxide and Anemia, Sickle Cell
46 other studies available for carbon monoxide and Anemia, Sickle Cell
Article | Year |
---|---|
SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update.
Topics: Anemia; Anemia, Sickle Cell; Animals; Blood Substitutes; Brain Ischemia; Carbon Monoxide; Carboxyhem | 2017 |
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.
Topics: Aldehydes; Anemia, Sickle Cell; Animals; Carbon Monoxide; Cytokines; Disease Models, Animal; Female; | 2018 |
Preliminary exploration of secondhand smoke exposure in youth with Sickle Cell Disease: biochemical verification, pulmonary functioning, and health care utilization.
Topics: Adolescent; Anemia, Sickle Cell; Carbon Monoxide; Child; Cotinine; Emergency Service, Hospital; Fema | 2019 |
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Antisickling Agents; Carbon Monoxide; Disease Mo | 2018 |
Validation of a noninvasive pulse CO-oximetry-based hemoglobin estimation in patients with sickle cell disease.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Hemoglobins; Humans; Oximetry; Prospective Studies; Reproducib | 2013 |
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Disease Models, Animal; Female; Guaiacol; Heme Oxygen | 2013 |
HO-1 and CO: fighters vs sickle cell disease?
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Female; Heme Oxygenase-1; Hemoglobins; Humans; Male; | 2013 |
Environmental influences on daily emergency admissions in sickle-cell disease patients.
Topics: Air Pollutants; Anemia, Sickle Cell; Carbon Monoxide; Emergency Service, Hospital; Humans; Multivari | 2014 |
Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.
Topics: Adolescent; Anemia, Sickle Cell; Bilirubin; Carbon Monoxide; Case-Control Studies; Child; Child, Pre | 2015 |
Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Blood Transfusion; Blood Volume; Blood Volume Determination; Capill | 2016 |
Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I.
Topics: Analgesics; Anemia, Sickle Cell; Apolipoprotein A-I; Carbon Monoxide; Clinical Trials as Topic; Cycl | 2008 |
Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease.
Topics: Administration, Inhalation; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Apoferritins; Ca | 2009 |
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anemia, Sickle Cell; Animals; Calcium; Calcium Cha | 2010 |
Elevated exhaled carbon monoxide concentration in hemoglobinopathies and its relation to red blood cell transfusion therapy.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Breath Tests; Carbon Monoxide; Child; Child, Preschool; Cros | 2010 |
The use of carbon monoxide to prevent sickle-cell formation.
Topics: Anemia; Anemia, Sickle Cell; Carbon Monoxide | 1963 |
FAILURE OF CARBONMONOXY SICKLE-CELL HAEMOGLOBIN TO ALTER THE SICKLE STATE.
Topics: Anemia; Anemia, Sickle Cell; Blood Gas Analysis; Carbon Monoxide; Child; Hemoglobin, Sickle; Hemoglo | 1964 |
Exhaled carbon monoxide levels in children with sickle cell disease.
Topics: Adolescent; Age Factors; Anemia, Sickle Cell; Bilirubin; Breath Tests; Carbon Monoxide; Case-Control | 2005 |
Abnormal pulmonary function in adults with sickle cell anemia.
Topics: Acute Disease; Adult; Aged; Anemia, Sickle Cell; Carbon Monoxide; Female; Humans; Logistic Models; L | 2006 |
Computed tomography and pulmonary function abnormalities in sickle cell disease.
Topics: Adolescent; Adult; Aged; Anemia, Sickle Cell; Biomarkers; Breath Tests; Carbon Monoxide; Female; Hem | 2006 |
Non-invasive carbon monoxide measurement is not accurate.
Topics: Anemia, Sickle Cell; Artifacts; Calibration; Carbon Monoxide; Carboxyhemoglobin; Emergency Service, | 2006 |
The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment.
Topics: Acute Disease; Adult; Air Pollutants; Air Pollution; Analysis of Variance; Anemia, Sickle Cell; Carb | 2007 |
Molecular stability and function of Hb C-Harlem.
Topics: Amino Acid Sequence; Anemia, Sickle Cell; Carbon Monoxide; Chemical Phenomena; Chemical Precipitatio | 1980 |
Increased blood viscosity in a patient with sickle cell anemia.
Topics: Acute Disease; Adult; Anemia, Sickle Cell; Blood Viscosity; Carbon Monoxide; Carbon Monoxide Poisoni | 1982 |
Kinetics of reactions within single erythrocytes: studies by microspectrophotometry.
Topics: Anemia, Sickle Cell; Animals; Binding Sites; Carbon Monoxide; Erythrocytes; Erythrocytes, Abnormal; | 1982 |
Carbon monoxide religation kinetics to hemoglobin S polymers following ligand photolysis.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Hemoglobin, Sickle; Humans; Kinetics; Ligands; Models, Theoret | 1995 |
Temperature and domain size dependence of sickle cell hemoglobin polymer melting in high concentration phosphate buffer.
Topics: Adult; Anemia, Sickle Cell; Biophysical Phenomena; Biophysics; Biopolymers; Buffers; Carbon Monoxide | 1999 |
A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells.
Topics: Adult; Amino Acid Transport System ASC; Amino Acid Transport System L; Anemia, Sickle Cell; Biologic | 2000 |
The effect of carbon monoxide on red cell life span in sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Carbon Monoxide; Carboxyhemoglobin; Cell Biology; Cell Survi | 1975 |
Kinetics of the reaction with CO of human erythrocytes. Observations by single cell spectroscopy.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Densitometry; Erythrocytes; Hemoglobins; Humans; Kinetics; Pho | 1978 |
Interpretation of lung function tests in the sickle-cell haemoglobinopathies.
Topics: Adult; Age Factors; Anemia, Sickle Cell; Black People; Carbon Monoxide; Female; Hemoglobin C; Hemogl | 1978 |
Single cell observations of gas reactions and shape changes in normal and sickling erythrocytes.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Diffusion; Erythrocytes; Erythrocytes, Abnormal; Kinetics; Pho | 1978 |
A new approach to the treatment of sickle cell anemia.
Topics: Anemia, Sickle Cell; Binding Sites; Carbon Monoxide; Hemoglobin, Sickle; Humans; Ligands; Methylene | 1975 |
Erythrocyte sickling in sika deer (Cervus nippon).
Topics: Air; Anemia, Sickle Cell; Animals; Breeding; Carbon Dioxide; Carbon Monoxide; Cells, Cultured; Deer; | 1991 |
Hemolysis in sickle cell disease as measured by endogenous carbon monoxide production. A preliminary report.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Cell Survival; Erythrocytes; Hematology; Hemoglobin C Disease; | 1988 |
Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo.
Topics: Anemia, Sickle Cell; Biopolymers; Carbon Monoxide; Erythrocytes, Abnormal; Gels; Hemoglobin, Sickle; | 1987 |
Non relationship of climatologic factors and painful sickle cell anemia crisis.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Carbon Monoxide; Child; Climate; Cold Temperature; Computers | 1986 |
Irreversibly sickled erythrocytes in sickle cell anemia: a quantitative reappraisal.
Topics: Anemia, Sickle Cell; Carbon Monoxide; Erythrocyte Count; Erythrocytes; Humans; Oxygen | 1985 |
Intravascular hemolysis associated with intravenous urea infusions in normal individuals.
Topics: Adult; Anemia, Sickle Cell; Carbon Monoxide; Cell Membrane; Erythrocytes; Erythrocytes, Abnormal; He | 1973 |
13C magnetic resonance studies of hemoglobin carbamylation.
Topics: Adult; Amino Acid Sequence; Anemia, Sickle Cell; Binding Sites; Carbon Isotopes; Carbon Monoxide; Ca | 1974 |
Asymmetrical hemoglobin hybrids. An approach to the study of subunit interactions.
Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cya | 1974 |
Effects of urea and cyanate on sickling in vitro.
Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Blood Viscosity; Carbon Monoxide; Cyanates; Erythrocytes; | 1972 |
An assessment of lung volumes and gas transfer in sickle-cell anaemia.
Topics: Adult; Anemia, Sickle Cell; Anthropometry; Blood Volume; Body Height; Body Weight; Carbon Monoxide; | 1971 |
Effect of intravenous urea in invert sugar on heme catabolism in sickle-cell anemia.
Topics: Anemia, Sickle Cell; Bilirubin; Blood Urea Nitrogen; Carbon Monoxide; Erythrocyte Count; Female; Fru | 1971 |
Carboxyhemoglobin levels as an index of hemolysis.
Topics: Adolescent; Adult; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Carbon Mon | 1971 |
Effect of anemia, species, and temperature on CO kinetics with red blood cells.
Topics: Anemia; Anemia, Hypochromic; Anemia, Sickle Cell; Animals; Blood Volume; Capillary Permeability; Car | 1971 |
Pulmonary function studies in sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Volume; Capillary Permeability; Carbon Monoxide; Diffu | 1970 |