carbetocin and Postoperative-Nausea-and-Vomiting

To compare the incidence of nausea, vomiting, and arterial hypotension between carbetocin and oxytocin to prevent haemorrhage after caesarean section (CS).. A randomized controlled trial in term pregnant women undergoing planned CS. Groups were randomized to carbetocin or oxytocin. Blood pressure (BP), heart rate, presence of nausea/vomitus, and need for vasopressors were evaluated throughout surgery. Preoperative and postoperative haemoglobin and haematocrit levels were compared.. Fifty-eight women were randomized (carbetocin. In planned CS, a possible clinical significant lower incidence of nausea after carbetocin was noted but this was not statistically significant. There were no differences regarding BP, heart rate, the need for vasopressor, and blood loss. The study was registered in the International Journal of Clinical Trials (ISRCTN 95504420, 2/2017).

Topics: Adult; Blood Pressure; Cesarean Section; Female; Heart Rate; Humans; Oxytocics; Oxytocin; Postoperative Nausea and Vomiting; Postpartum Hemorrhage; Pregnancy

The administration of oxytocic drugs during caesarean section is an important intervention to prevent uterine atony or treat established postpartum haemorrhage. Considerable past and current research has shown that these agents have a narrow therapeutic range. A detailed knowledge by anaesthetists of optimal doses and side effects is therefore required. Oxytocin remains the first line agent. In view of receptor desensitisation, second line agents may be required, namely ergot alkaloids and prostaglandins. This review examines the adverse haemodynamic and side effects, and methods for their limitation. An approach to dosing and choices of agent for the limitation of postpartum haemorrhage is suggested.

Topics: Adult; Cesarean Section; Ergonovine; Ergot Alkaloids; Female; Humans; Oxytocics; Oxytocin; Postoperative Nausea and Vomiting; Pregnancy; Prostaglandins; Uterine Diseases; Uterine Inertia