Page last updated: 2024-10-24

carbazilquinone and Stomach Neoplasms

carbazilquinone has been researched along with Stomach Neoplasms in 19 studies

Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.

Stomach Neoplasms: Tumors or cancer of the STOMACH.

Research Excerpts

ExcerptRelevanceReference
" We determined the increase in antineoplastic activities of mitomycin C (MMC) and carboquone (CQ) against human tumor cells under conditions of in vitro hypoxia, with the following results."7.67Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro. ( Kusumoto, T; Maehara, Y; Sakaguchi, Y; Saku, M; Sugimachi, K, 1989)
"In 62 human gastric carcinomas, the expression of GST pi was immunohistochemically evaluated, and sensitivity to the anticancer drugs, cisplatin (CDDP), doxorubicin (DXR) aclacinomycin A (aclarubicin), (ACR), 5-fluorouracil (5-FU), mitomycin C (MMC) and carboquone (carbazilquinon) (CQ) was examined using the in vitro succinate dehydrogenase inhibition test."3.69Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin. ( Adachi, Y; Baba, H; Endo, K; Kuwano, M; Maehara, Y; Okuyama, T; Sugimachi, K, 1994)
" We determined the increase in antineoplastic activities of mitomycin C (MMC) and carboquone (CQ) against human tumor cells under conditions of in vitro hypoxia, with the following results."3.67Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro. ( Kusumoto, T; Maehara, Y; Sakaguchi, Y; Saku, M; Sugimachi, K, 1989)
"Fifty of 80 cases had advanced gastric cancer, 30 had pancreatic cancer or other cancers, such as colon cancer, and biliary tract cancer."2.66[Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy]. ( Baba, T; Furukohori, N; Itoh, T; Kawata, K; Kimura, T; Munakata, A; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y, 1988)
"Survival rate of stage III stomach cancer patients in Group B was higher than that in Group A, the difference being statistically significant between 20 and 24 months after surgery."2.66[Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer. Cooperative Study Group of Cancer Immunochemotherapy, Tokai Gastrointestinal On ( Ichihashi, H; Kondo, T; Nakazato, H, 1986)
"The in vitro drug sensitivity of gastric cancer tissues obtained from 40 patients with advanced cancer was compared in terms of the pathological classifications which were assigned according to the General Rules for the Gastric Cancer Study in Surgery and Pathology in Japan."1.28Relationship between tumor histopathology and in vitro sensitivity to antitumor drugs in gastric cancer. ( Anai, H; Kusumoto, H; Maehara, Y; Sugimachi, K; Takahashi, I; Yoshida, M, 1992)
"Etoposide was found to be most effective against gastric carcinoma in this test."1.28[Chemosensitivity test for gastric cancer by in vitro MTT assay]. ( Endo, Y; Kimura, H; Kinoshita, K; Miyazaki, I; Ninomiya, I; Ohyama, S; Sasaki, T; Tanaka, M; Tugawa, K; Yonemura, Y, 1991)
"A case of relapsed gastric cancer postoperatively presenting obstructive jaundice due to metastases in the hepatic portal and periaortic lymph nodes and multiple lung metastases was given OK-432 continuously i."1.27[A case of relapsed gastric cancer treated successfully by chemotherapy--lung metastasis and relapsed cancer in the hepatic portal system]. ( Kawahara, M; Matsuo, T; Nagamatsu, Y; Nakarai, I; Shinoda, A, 1986)
"In 8 cases of advanced and/or relapsed gastric cancer (7 cases advanced, 1 case relapsed), we undertook combination chemotherapy with systemic administration of cisplatin and celiac arterial infusion of carboquone intermittently under continuous administration of OK-432 i."1.27[Clinical study of combination chemotherapy using carboquone, cisplatin, UFT and OK-432 in 7 cases of advanced gastric cancers and a relapsed gastric cancer]. ( Horiuchi, M; Nakarai, I; Nasu, K; Shinoda, A, 1988)
"The Kuramochi cell line, derived from undifferentiated carcinoma, was less sensitive to Mitomycin C than the groups of gastric cancer cell line."1.26[Quantitative analysis on in vitro drug sensitivity of cultured human ovarian cancer cell lines (author's transl)]. ( Motoyama, T, 1982)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199013 (68.42)18.7374
1990's6 (31.58)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sakata, Y3
Yoshida, Y2
Komatsu, Y2
Sugawara, K2
Nishimura, S2
Kikuchi, K2
Motoyama, T1
Okuyama, T1
Maehara, Y5
Endo, K1
Baba, H1
Adachi, Y1
Kuwano, M1
Sugimachi, K5
Takenaka, T1
Maruyama, K1
Kinoshita, T1
Sasako, M1
Sano, T1
Katai, H1
Matsuno, Y1
Ogawa, M1
Kusumoto, H3
Yoshida, M1
Takahashi, I1
Anai, H3
Kondo, T3
Sakamoto, J1
Nakazato, H3
Ohyama, S1
Yonemura, Y1
Kinoshita, K1
Ninomiya, I1
Tugawa, K1
Kimura, H1
Miyazaki, I1
Tanaka, M1
Endo, Y1
Sasaki, T1
Nio, Y1
Imai, S1
Shiraishi, T1
Tsubono, M1
Morimoto, H1
Tseng, CC1
Tobe, T1
Kusumoto, T2
Sakaguchi, Y1
Saku, M1
Yagita, A1
Orima, I1
Okada, N1
Ootsuka, S1
Oda, T1
Takeuchi, N1
Hosaka, N1
Matsumoto, H1
Itoh, H1
Ono, M1
Nagamatsu, Y1
Nakarai, I2
Matsuo, T1
Kawahara, M1
Shinoda, A2
Munakata, A1
Baba, T1
Saitoh, S1
Itoh, T1
Tamura, Y1
Furukohori, N1
Suzuki, H1
Kimura, T1
Kawata, K1
Nasu, K1
Horiuchi, M1
Ichihashi, H2

Reviews

1 review available for carbazilquinone and Stomach Neoplasms

ArticleYear
A recent overview of chemotherapy for advanced stomach cancer in Japan.
    Antibiotics and chemotherapy, 1978, Volume: 24

    Topics: Antineoplastic Agents; Carbazilquinone; Chromomycins; Drug Therapy, Combination; Fluorouracil; Human

1978

Trials

5 trials available for carbazilquinone and Stomach Neoplasms

ArticleYear
A prospective study of surgery and adjuvant chemotherapy for primary gastric lymphoma stage II.
    British journal of cancer, 1997, Volume: 76, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Che

1997
Alternating immunochemotherapy of advanced gastric carcinoma: a randomized comparison of carbazilquinone and PSK to carbazilquinone in patients with curative gastric resection.
    Biotherapy (Dordrecht, Netherlands), 1991, Volume: 3, Issue:4

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Adult; Aged; Carbazilquinone; Combined Modality Therapy; Dru

1991
[Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Clinical Trials as Top

1988
[Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer--7-year survival--Cooperative Study Group for Cancer Immunochemotherapy, Tokai G
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:9

    Topics: Adjuvants, Immunologic; Administration, Oral; Azirines; Carbazilquinone; Clinical Trials as Topic; C

1987
[Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer. Cooperative Study Group of Cancer Immunochemotherapy, Tokai Gastrointestinal On
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:2

    Topics: Adjuvants, Immunologic; Aged; Azirines; Carbazilquinone; Colonic Neoplasms; Drug Administration Sche

1986

Other Studies

13 other studies available for carbazilquinone and Stomach Neoplasms

ArticleYear
[MQF-OK therapy in advanced terminal stomach cancer--with special reference to a comparison with MFC therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:1

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Cytara

1982
[Quantitative analysis on in vitro drug sensitivity of cultured human ovarian cancer cell lines (author's transl)].
    Nihon Sanka Fujinka Gakkai zasshi, 1982, Volume: 34, Issue:3

    Topics: Azirines; Carbazilquinone; Carcinoma; Cell Line; Cell Survival; Cystadenocarcinoma; Dose-Response Re

1982
Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin.
    Cancer, 1994, Aug-15, Volume: 74, Issue:4

    Topics: Aclarubicin; Animals; Carbazilquinone; Carcinoma; Cell Nucleus; CHO Cells; Cisplatin; Cricetinae; Cy

1994
[Combination chemotherapy of mitomycin-C, carboquone, 5-fluorouracil and OK-432 for inoperable gastric cancer (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1979, Oct-20, Volume: 14, Issue:6

    Topics: Aged; Antineoplastic Agents; Carbazilquinone; Drug Therapy, Combination; Female; Fluorouracil; Human

1979
Relationship between tumor histopathology and in vitro sensitivity to antitumor drugs in gastric cancer.
    Anti-cancer drugs, 1992, Volume: 3, Issue:1

    Topics: Aclarubicin; Adenocarcinoma; Antineoplastic Agents; Carbazilquinone; Cisplatin; Doxorubicin; Drug Sc

1992
[Chemosensitivity test for gastric cancer by in vitro MTT assay].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Antineoplastic Agents; Carbazilquinone; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Et

1991
Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph nodes of patients evaluated by DNA synthesis inhibition assay.
    Cancer, 1990, Mar-15, Volume: 65, Issue:6

    Topics: Breast Neoplasms; Carbazilquinone; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Doxorubicin; Drug

1990
Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1989, Volume: 21, Issue:3-4

    Topics: Azirines; Carbazilquinone; Carcinoma; Cells, Cultured; Colorectal Neoplasms; HeLa Cells; Humans; Hyp

1989
Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro.
    Journal of surgical oncology, 1989, Volume: 40, Issue:1

    Topics: Aclarubicin; Azirines; Carbazilquinone; Cell Survival; Colorectal Neoplasms; Drug Screening Assays,

1989
[A case report of patient with advanced stomach carcinoma of linitis plastica type responding to multi-immunotherapy and chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:1

    Topics: Adenocarcinoma, Scirrhous; Adult; Antineoplastic Combined Chemotherapy Protocols; Biological Product

1987
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1987, Volume: 13, Issue:3

    Topics: Aclarubicin; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Antineoplastic Age

1987
[A case of relapsed gastric cancer treated successfully by chemotherapy--lung metastasis and relapsed cancer in the hepatic portal system].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:12

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Humans; Liver

1986
[Clinical study of combination chemotherapy using carboquone, cisplatin, UFT and OK-432 in 7 cases of advanced gastric cancers and a relapsed gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:8 Pt 2

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carbazilquinone;

1988
chemdatabank.com