carbamyl phosphate has been researched along with Deficiency Disease, Ornithine Carbamoyltransferase in 9 studies
Carbamyl Phosphate: The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
| Excerpt | Relevance | Reference |
|---|---|---|
| "3 kb of the 5' flanking region of the rat OTC gene fused to rat OTC cDNA on urinary orotic acid excretion in OTC-deficient spf-ash (sparse-fur with abnormal skin and hair) mice during overnight-starvation and nitrogen loading." | 3.69 | Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: analysis of OTC-deficient spf-ash mice with OTC transgene. ( Horiuchi, M; Kobayashi, K; Mori, K; Mori, M; Obara, T; Saheki, T; Shige, T; Suzuki, S; Yamamura, K, 1995) |
| "Metabolic observations during early stages of hyperammonemia in two infants with ornithine transcarbamylase deficiency suggest that plasma alpha-ketoglutarate concentration ([alpha-KG]) becomes subnormal before the development of hyperammonemic coma." | 3.66 | Plasma alpha-ketoglutarate in urea cycle enzymopathies and its role as a harbinger of hyperammonemic coma. ( Batshaw, ML; Brusilow, SW; Walser, M, 1980) |
| "OTC deficiency is an X-linked genetic disorder ranging from fatal in newborns to hyperammonemia and anorexia in adults." | 1.35 | Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. ( Guan, KL; Huang, W; Lei, Q; Lin, Y; Xiong, Y; Yao, J; Yu, W; Zhao, S, 2009) |
| "An unusual form of ornithine transcarbamylase deficiency was found in a male child who became unconscious at 8 months." | 1.27 | Immunological evidence for an ornithine transcarbamylase lesion resulting in the formation of enzyme with smaller protein subunits. ( Danks, DM; Hoogenraad, N; Luisa de Martinis, M, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kok, CY | 1 |
| Cunningham, SC | 1 |
| Kuchel, PW | 1 |
| Alexander, IE | 1 |
| Yu, W | 1 |
| Lin, Y | 1 |
| Yao, J | 1 |
| Huang, W | 1 |
| Lei, Q | 1 |
| Xiong, Y | 1 |
| Zhao, S | 1 |
| Guan, KL | 1 |
| Hoogenraad, N | 1 |
| Luisa de Martinis, M | 1 |
| Danks, DM | 1 |
| Spector, EB | 1 |
| Mazzocchi, RA | 1 |
| Batshaw, ML | 2 |
| Walser, M | 1 |
| Brusilow, SW | 1 |
| Nagata, N | 1 |
| Akaboshi, I | 1 |
| Yamamoto, J | 1 |
| Matsuda, I | 1 |
| Ohtsuka, H | 1 |
| Katsuki, T | 1 |
| Saheki, T | 1 |
| Mori, K | 1 |
| Kobayashi, K | 1 |
| Horiuchi, M | 1 |
| Shige, T | 1 |
| Obara, T | 1 |
| Suzuki, S | 1 |
| Mori, M | 1 |
| Yamamura, K | 1 |
| Rabier, D | 1 |
| Benoit, A | 1 |
| Petit, F | 1 |
| Chekoury, A | 1 |
| Bonnefont, JP | 1 |
| Saudubray, JM | 1 |
| Kamoun, P | 1 |
9 other studies available for carbamyl phosphate and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
Insights into Gene Therapy for Urea Cycle Defects by Mathematical Modeling.
Topics: Carbamyl Phosphate; Computer Simulation; Genetic Therapy; Humans; Models, Biological; Ornithine Carb | 2019 |
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.
Topics: Acetylation; Carbamyl Phosphate; Cell Line; Humans; Infant, Newborn; Kinetics; Lysine; Mutation; Orn | 2009 |
Immunological evidence for an ornithine transcarbamylase lesion resulting in the formation of enzyme with smaller protein subunits.
Topics: Carbamyl Phosphate; Humans; Immunologic Techniques; Infant; Kinetics; Liver; Macromolecular Substanc | 1983 |
The sparse fur mouse: an animal model for a human inborn error of metabolism of the urea cycle.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Disease Models, Animal; | 1983 |
Plasma alpha-ketoglutarate in urea cycle enzymopathies and its role as a harbinger of hyperammonemic coma.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinate Synthase; Argini | 1980 |
Ornithine transcarbamylase (OTC) in white blood cells.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Carbon Radioisotopes; Ca | 1980 |
Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: analysis of OTC-deficient spf-ash mice with OTC transgene.
Topics: Animals; Carbamyl Phosphate; Intestine, Small; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ni | 1995 |
Ornithine carbamoyltransferase deficiency. A new variant with subnormal enzyme activity.
Topics: Amino Acids; Carbamyl Phosphate; Humans; Hydrogen-Ion Concentration; Infant; Kinetics; Liver; Male; | 1989 |
The diagnosis of ornithine transcarbamylase deficiency.
Topics: Animals; Carbamyl Phosphate; Citrulline; Coma; Female; Humans; Infant; Infant, Newborn; Intellectual | 1985 |