carbamazepine epoxide has been researched along with Seizures in 8 studies
carbamazepine epoxide: metabolite of carbamazepine; RN given refers to unlabeled cpd
carbamazepine-10,11-epoxide : An epoxide and metabolite of carbamazepine.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Initial studies of the effect of chronic carbamazepine (CBZ) against cocaine-induced seizures indicated that there were genetic differences in both the time course for the development of the anticonvulsant effects of CBZ against cocaine-induced seizures and the persistence of these effects." | 7.68 | Genetic differences in the time course for the development and persistence of the anticonvulsant effects of carbamazepine against cocaine seizures. ( Frieman, M; Goldberg, SR; Marley, RJ; Shimosato, K, 1993) |
| "Fourteen animals with stable generalized kindled seizures received three doses of carbamazepine and its epoxide (12." | 7.67 | Effects of carbamazepine and its epoxide metabolite on amygdala-kindled seizures in rats. ( Albright, PS; Bruni, J, 1984) |
| "The effect of carbamazepine and its -10,11-epoxide on the development of amygdala-kindled seizures and on completed kindled seizures in the rat was evaluated." | 7.67 | Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development. ( Post, RM; Weiss, SR, 1987) |
| "In adults with focal seizures, adjunctive BRV treatment does not affect plasma concentrations of the evaluated AEDs but increases carbamazepine epoxide metabolite." | 5.30 | Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials. ( Moseley, BD; Otoul, C; Staelens, L; Stockis, A, 2019) |
| "Initial studies of the effect of chronic carbamazepine (CBZ) against cocaine-induced seizures indicated that there were genetic differences in both the time course for the development of the anticonvulsant effects of CBZ against cocaine-induced seizures and the persistence of these effects." | 3.68 | Genetic differences in the time course for the development and persistence of the anticonvulsant effects of carbamazepine against cocaine seizures. ( Frieman, M; Goldberg, SR; Marley, RJ; Shimosato, K, 1993) |
| "Fourteen animals with stable generalized kindled seizures received three doses of carbamazepine and its epoxide (12." | 3.67 | Effects of carbamazepine and its epoxide metabolite on amygdala-kindled seizures in rats. ( Albright, PS; Bruni, J, 1984) |
| "The effect of carbamazepine and its -10,11-epoxide on the development of amygdala-kindled seizures and on completed kindled seizures in the rat was evaluated." | 3.67 | Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development. ( Post, RM; Weiss, SR, 1987) |
| "Pharmacokinetic parameters, seizure control, effects on the behavioral state, and tolerability were considered." | 2.67 | A comparison of carbamazepine Divitabs and a normal carbamazepine preparation in psychiatric and oligophrenic patients. ( Doorschot, CH; Loonen, AJ; Nijdam, JR; van Bavel, LP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Moseley, BD | 1 |
| Otoul, C | 1 |
| Staelens, L | 1 |
| Stockis, A | 1 |
| Steinhoff, BJ | 1 |
| Bacher, M | 1 |
| Blickhan, M | 1 |
| Bernedo, V | 1 |
| Dietmann, D | 1 |
| Intravooth, T | 1 |
| Kornmeier, R | 1 |
| Kurth, C | 1 |
| Mahn, P | 1 |
| Schneider, M | 1 |
| Stockinger, J | 1 |
| Staack, AM | 1 |
| Bourgeois, BF | 1 |
| Wad, N | 1 |
| Albright, PS | 1 |
| Bruni, J | 1 |
| So, EL | 1 |
| Ruggles, KH | 1 |
| Cascino, GD | 1 |
| Ahmann, PA | 1 |
| Weatherford, KW | 1 |
| Marley, RJ | 1 |
| Shimosato, K | 1 |
| Frieman, M | 1 |
| Goldberg, SR | 1 |
| Nijdam, JR | 1 |
| Doorschot, CH | 1 |
| van Bavel, LP | 1 |
| Loonen, AJ | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
2 trials available for carbamazepine epoxide and Seizures
| Article | Year |
|---|---|
Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; | 2019 |
A comparison of carbamazepine Divitabs and a normal carbamazepine preparation in psychiatric and oligophrenic patients.
Topics: Adult; Aged; Behavior; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Female; Huma | 1992 |
6 other studies available for carbamazepine epoxide and Seizures
| Article | Year |
|---|---|
Is brivaracetam-induced elevation of carbamazepine-epoxide levels common and clinically relevant? - A case series.
Topics: Adult; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Pyrrolidinones; Seizur | 2020 |
Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice.
Topics: Animals; Brain; Carbamazepine; Drug Synergism; Female; Mice; Mice, Inbred ICR; Nervous System; Proad | 1984 |
Effects of carbamazepine and its epoxide metabolite on amygdala-kindled seizures in rats.
Topics: Amygdala; Animals; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Seizure exacerbation and status epilepticus related to carbamazepine-10,11-epoxide.
Topics: Adult; Age of Onset; Carbamazepine; Female; Humans; Male; Middle Aged; Phenytoin; Seizures; Status E | 1994 |
Genetic differences in the time course for the development and persistence of the anticonvulsant effects of carbamazepine against cocaine seizures.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cocaine; Diet; Male; Mice; Mice, Inbred BALB C; Mice | 1993 |
Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development.
Topics: Amygdala; Animals; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1987 |