carbamazepine epoxide has been researched along with Epilepsy in 87 studies
carbamazepine epoxide: metabolite of carbamazepine; RN given refers to unlabeled cpd
carbamazepine-10,11-epoxide : An epoxide and metabolite of carbamazepine.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind, randomized, parallel-group, placebo-controlled trial, we assessed the effect of add-on melatonin (6-9 mg/day for 14 days) on the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GRd) in 31 children with epilepsy receiving CBZ monotherapy, who were seizure free at least for the last 6 months." | 9.11 | Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. ( Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kalaivani, M; Kohli, K, 2004) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 7.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "The case of a patient who developed thrombocytopenia during treatment with carbamazepine (CBZ) is described." | 7.69 | Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report. ( Kimura, M; Maeoka, Y; Suzuki, N; Yoshino, K, 1995) |
| "We report the first comparison of Chewable and Regular Carbamazepine (CBZ) tablets in children with epilepsy." | 7.68 | The pharmacology of chewable versus regular carbamazepine in chronically treated children with epilepsy. ( al-Quadah, AK; Camfield, C; Camfield, P; Fraser, A; Hwang, P; Soldin, S, 1992) |
| "Simultaneous steady-state serum total and free (non-protein-bound) concentrations of carbamazepine and carbamazepine-10,11-epoxide were measured in 68 patients under the age of 21 years with epilepsy (44 males, 24 females; mean age, 11." | 7.67 | Total and free serum concentrations of carbamazepine and carbamazepine-10,11-epoxide in children with epilepsy. ( Agbato, OA; Brett, EM; Elyas, AA; Lascelles, PT; Patsalos, PN, 1986) |
| "Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs." | 7.67 | Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| " The bioavailability of CBZ from the two preparations was similar." | 6.67 | Treatment of epilepsy in mentally retarded patients with a slow-release carbamazepine preparation. ( Anttila, M; Heinonen, E; Kaski, M; Sivenius, J; Tuominen, J, 1991) |
| "The in-vitro dissolution profiles of two carbamazepine formulations (Tegretol and a generic carbamazepine) have been assessed and the bioavailability of carbamazepine compared in 12 epileptic children at steady-state." | 6.67 | Dissolution and relative bioavailability of two carbamazepine preparations for children with epilepsy. ( Aleksandrowicz, J; Bowmer, CJ; Cawood, A; Forsythe, WI; Hartley, R, 1991) |
| " Dosing was single blind." | 5.28 | Carbamazepine-10,11-epoxide in epilepsy. A pilot study. ( Almkvist, O; Bertilsson, L; Nilsson, BY; Svensson, JO; Tomson, T, 1990) |
| "In a double-blind, randomized, parallel-group, placebo-controlled trial, we assessed the effect of add-on melatonin (6-9 mg/day for 14 days) on the antioxidant enzymes glutathione peroxidase (GPx) and glutathione reductase (GRd) in 31 children with epilepsy receiving CBZ monotherapy, who were seizure free at least for the last 6 months." | 5.11 | Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. ( Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kalaivani, M; Kohli, K, 2004) |
| "Carbamazepine is one of the three most frequently prescribed antiepileptic drugs in pregnancy." | 3.83 | Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2016) |
| "To study the effects of delayed and missed doses (poor compliance) on the pharmacokinetics of carbamazepine (CBZ) and its main active metabolite carbamazepine-10,11-epoxide (CBZE) in Chinese epilepsy patients using Monte Carlo simulation." | 3.78 | The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation. ( Ding, JJ; Jiao, Z; Wang, Y; Zhang, YJ, 2012) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 3.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "The case of a patient who developed thrombocytopenia during treatment with carbamazepine (CBZ) is described." | 3.69 | Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report. ( Kimura, M; Maeoka, Y; Suzuki, N; Yoshino, K, 1995) |
| "The in vivo serum protein binding characteristics of carbamazepine and carbamazepine 10, 11-epoxide, which was the main metabolite of carbamazepine in plasma, were assessed in sera from 30 adult patients with epilepsy on carbamazepine monotherapy." | 3.69 | In vivo binding characteristics of carbamazepine and carbamazepine 10, 11-epoxide to serum proteins in monotherapy adult patients. ( Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Okamoto, T; Takeyama, M; Tsutsumi, K; Yasunaga, F, 1994) |
| "Carbamazepine (CBZ) used in the treatment of epilepsy, is metabolized in man to an active metabolite: carbamazepine 10-11 epoxide (CBZ-E)." | 3.68 | Distribution of carbamazepine and its epoxide in blood compartments in adolescent and adult epileptic patients. ( Bonneton, J; Genton, P; Mesdjian, E, 1992) |
| "We report the first comparison of Chewable and Regular Carbamazepine (CBZ) tablets in children with epilepsy." | 3.68 | The pharmacology of chewable versus regular carbamazepine in chronically treated children with epilepsy. ( al-Quadah, AK; Camfield, C; Camfield, P; Fraser, A; Hwang, P; Soldin, S, 1992) |
| "Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three." | 3.68 | Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990) |
| "Using an open substitution study design, conventional carbamazepine (Tegretol, CBZ-C and a chewable carbamazepine formulation (Tegretol Chewtabs, CBZ-CHEW) were compared in 12 patients with severe intractable epilepsy." | 3.68 | A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients. ( Patsalos, PN, 1990) |
| "A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy." | 3.67 | Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| "Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs." | 3.67 | Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| "A battery of psychometric tests was administered to 85 patients with epilepsy, of whom 26 were untreated, 40 received carbamazepine monotherapy and 19 took carbamazepine with another anticonvulsant." | 3.67 | Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients. ( Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, K; Williams, N, 1988) |
| "Simultaneous steady-state serum total and free (non-protein-bound) concentrations of carbamazepine and carbamazepine-10,11-epoxide were measured in 68 patients under the age of 21 years with epilepsy (44 males, 24 females; mean age, 11." | 3.67 | Total and free serum concentrations of carbamazepine and carbamazepine-10,11-epoxide in children with epilepsy. ( Agbato, OA; Brett, EM; Elyas, AA; Lascelles, PT; Patsalos, PN, 1986) |
| "For a period of 8 years, carbamazepine (CBZ) and its two major metabolites carbamazepine-10,11-epoxide (CBZE) and 10,11-dihydroxy-carbamazepine (CBZH) were monitored in plasma of black and white patients visiting outpatient epilepsy clinics." | 3.66 | Carbamazepine and its major metabolites in plasma: a summary of eight years of therapeutic drug monitoring. ( Aucamp, AK; Hundt, HK; Müller, FO; Potgieter, MA, 1983) |
| "Carbamazepine is a widely used anticonvulsive agent." | 2.76 | Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication. ( Breton, H; Demoly, P; Gelisse, P; Hillaire-Buys, D; Mathieu, O; Picot, MC, 2011) |
| "Plasma carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) concentrations were measured in 160 epileptic patients in order to determine the effect of factors such as age, daily dosing schedule, formulation, and combination with other antiepileptic drugs on these concentrations in relation to the daily dose." | 2.68 | Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults. ( Bonato, PS; Campos, GM; Lanchote, VL; Rodrigues, I, 1995) |
| "The in-vitro dissolution profiles of two carbamazepine formulations (Tegretol and a generic carbamazepine) have been assessed and the bioavailability of carbamazepine compared in 12 epileptic children at steady-state." | 2.67 | Dissolution and relative bioavailability of two carbamazepine preparations for children with epilepsy. ( Aleksandrowicz, J; Bowmer, CJ; Cawood, A; Forsythe, WI; Hartley, R, 1991) |
| "Felbamate is a novel antiepileptic drug that is now available in the United States." | 2.67 | Effect of felbamate on carbamazepine and its major metabolites. ( Graves, NM; Leppik, IE; Remmel, RP; Wagner, ML, 1993) |
| "01) in serum CBZ concentration were substantially less with CBZ-CR and were similar to those calculated during a 6 or 8 hourly dosage interval with conventional CBZ (fluctuation 33 +/- 3%, variation 42 +/- 5%)." | 2.67 | Monotherapy with conventional and controlled-release carbamazepine: a double-blind, double-dummy comparison in epileptic patients. ( Blacklaw, J; Brodie, MJ; Butler, E; Gillham, RA; McKee, PJ, 1991) |
| " The bioavailability of CBZ from the two preparations was similar." | 2.67 | Treatment of epilepsy in mentally retarded patients with a slow-release carbamazepine preparation. ( Anttila, M; Heinonen, E; Kaski, M; Sivenius, J; Tuominen, J, 1991) |
| " This appears to be the result of a pharmacodynamic interaction." | 1.30 | Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? ( Berry, DJ; Besag, FM; Newbery, JE; Pool, F; Subel, B, 1998) |
| " Carbamazepine and both metabolites showed significant differences in mean 4h post-dose plasma concentrations between day and night dosing (p less than 0." | 1.28 | Daily variations in steady-state plasma concentrations of carbamazepine and its metabolites in epileptic children. ( Forsythe, WI; Hartley, R; Lucock, MD; McLain, B; Ng, PC, 1991) |
| "007) and a significantly shorter plasma half-life (mean values +/- SD = 4." | 1.28 | Effect of phenobarbital on the pharmacokinetics of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine. ( Fazio, A; Martines, C; Pisani, F; Spina, E; Tomson, T; Trio, R, 1991) |
| " Dosing was single blind." | 1.28 | Carbamazepine-10,11-epoxide in epilepsy. A pilot study. ( Almkvist, O; Bertilsson, L; Nilsson, BY; Svensson, JO; Tomson, T, 1990) |
| " dosing schedule, total plasma levels of CBZ and CBZ-E fluctuated to a similar extent (average 34% and 29%, respectively)." | 1.27 | Free and total plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients: diurnal fluctuations and relationship with side effects. ( Albani, F; Ambrosetto, G; Baruzzi, A; Contin, M; Cortelli, P; Gobbi, G; Perucca, E; Procaccianti, G; Riva, R, 1984) |
| " Relatively large fluctuations were observed for both CBZ (mean, 57%; range, 32-100%) and EP (mean, 97%; range, 19-189%) during a dosage interval." | 1.27 | Fluctuations in salivary carbamazepine and carbamazepine-10,11-epoxide concentrations during the day in epileptic children. ( Aman, MG; Paxton, JW; Werry, JS, 1983) |
| "Steady state carbamazepine (CBZ) plasma concentrations were similar in 15 epileptics receiving monotherapy and in 24 patients taking CBZ in combination with one other anticonvulsant." | 1.27 | Carbamazepine 10, 11 epoxide concentrations in epileptics on carbamazepine alone and in combination with other anticonvulsants. ( Brodie, MJ; Forrest, G; Rapeport, WG, 1983) |
| " Daily fluctuations in serum levels of carbamazepine and carbamazepine-10,11-epoxide did not appear to be related to the dosage schedule, but some patients tended to have lower fluctuations when the carbamazepine was given more frequently." | 1.26 | CSF concentrations and serum protein binding of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients. ( Bakke, J; Gerna, M; Johannessen, SI; Morselli, PL; Strandjord, RE, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (35.63) | 18.7374 |
| 1990's | 44 (50.57) | 18.2507 |
| 2000's | 6 (6.90) | 29.6817 |
| 2010's | 6 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, GX | 1 |
| Shen, ML | 1 |
| Zhang, Z | 1 |
| Wang, P | 1 |
| Xie, CX | 1 |
| He, GH | 1 |
| Patsalos, PN | 4 |
| Zugman, M | 1 |
| Lake, C | 1 |
| James, A | 1 |
| Ratnaraj, N | 1 |
| Sander, JW | 1 |
| Kacirova, I | 1 |
| Grundmann, M | 1 |
| Brozmanova, H | 1 |
| Qu, L | 1 |
| Fan, Y | 1 |
| Wang, W | 1 |
| Ma, K | 1 |
| Yin, Z | 1 |
| Mathieu, O | 1 |
| Picot, MC | 1 |
| Gelisse, P | 1 |
| Breton, H | 1 |
| Demoly, P | 1 |
| Hillaire-Buys, D | 1 |
| Johannessen, SI | 1 |
| Gerna, M | 1 |
| Bakke, J | 1 |
| Strandjord, RE | 1 |
| Morselli, PL | 2 |
| Ding, JJ | 1 |
| Zhang, YJ | 1 |
| Jiao, Z | 1 |
| Wang, Y | 1 |
| Pieters, MS | 1 |
| van Steveninck, AF | 1 |
| Schoemaker, RC | 1 |
| Kroon, JM | 1 |
| van Gerven, JM | 1 |
| Cohen, AF | 1 |
| Gupta, M | 1 |
| Gupta, YK | 1 |
| Agarwal, S | 1 |
| Aneja, S | 1 |
| Kalaivani, M | 1 |
| Kohli, K | 1 |
| Nakajima, Y | 1 |
| Saito, Y | 1 |
| Shiseki, K | 1 |
| Fukushima-Uesaka, H | 1 |
| Hasegawa, R | 1 |
| Ozawa, S | 1 |
| Sugai, K | 1 |
| Katoh, M | 1 |
| Saitoh, O | 1 |
| Ohnuma, T | 1 |
| Kawai, M | 1 |
| Ohtsuki, T | 1 |
| Suzuki, C | 1 |
| Minami, N | 1 |
| Kimura, H | 1 |
| Goto, Y | 1 |
| Kamatani, N | 1 |
| Kaniwa, N | 1 |
| Sawada, J | 1 |
| Yoshida, T | 1 |
| Imai, K | 1 |
| Motohashi, S | 1 |
| Hamano, S | 1 |
| Sato, M | 1 |
| Meijer, JW | 3 |
| Binnie, CD | 1 |
| Debets, RM | 1 |
| van Parys, JA | 1 |
| de Beer-Pawlikowski, NK | 1 |
| Froescher, W | 1 |
| Eichelbaum, M | 1 |
| Niesen, M | 1 |
| Dietrich, K | 1 |
| Rausch, P | 1 |
| Levy, RH | 2 |
| Moreland, TA | 1 |
| Guyot, M | 1 |
| Brachet-Liermain, A | 1 |
| Loiseau, P | 1 |
| Schoeman, JF | 2 |
| Elyas, AA | 4 |
| Brett, EM | 4 |
| Lascelles, PT | 4 |
| Bourgeois, BF | 1 |
| Wad, N | 1 |
| Riva, R | 3 |
| Contin, M | 3 |
| Albani, F | 3 |
| Perucca, E | 4 |
| Ambrosetto, G | 2 |
| Gobbi, G | 1 |
| Cortelli, P | 1 |
| Procaccianti, G | 2 |
| Baruzzi, A | 3 |
| Paxton, JW | 2 |
| Aman, MG | 1 |
| Werry, JS | 1 |
| Hundt, HK | 1 |
| Aucamp, AK | 1 |
| Müller, FO | 1 |
| Potgieter, MA | 1 |
| Brodie, MJ | 5 |
| Forrest, G | 1 |
| Rapeport, WG | 2 |
| Kuhnz, W | 2 |
| Jäger-Roman, E | 1 |
| Rating, D | 1 |
| Deichl, A | 1 |
| Kunze, J | 1 |
| Helge, H | 1 |
| Nau, H | 3 |
| Steldinger, R | 1 |
| Sawchuk, RJ | 1 |
| Cartier, LL | 1 |
| MacKichan, JJ | 2 |
| Duffner, PK | 1 |
| Cohen, ME | 1 |
| Krag, B | 1 |
| Dam, M | 1 |
| Angelo, H | 1 |
| Christensen, JM | 1 |
| Liu, H | 4 |
| Delgado, MR | 3 |
| Lanchote, VL | 1 |
| Bonato, PS | 1 |
| Campos, GM | 1 |
| Rodrigues, I | 1 |
| Schnabel, R | 6 |
| Rambeck, B | 8 |
| May, T | 7 |
| Jürgens, U | 6 |
| Lahl, R | 3 |
| Kodama, Y | 3 |
| Kuranari, M | 3 |
| Tsutsumi, K | 3 |
| Okamoto, T | 1 |
| Kodama, H | 3 |
| Yasunaga, F | 1 |
| Fujii, I | 3 |
| Takeyama, M | 3 |
| Sinués, B | 1 |
| Gazulla, J | 1 |
| Bernal, ML | 1 |
| Lanuza, J | 1 |
| Fanlo, A | 1 |
| Saenz, MA | 1 |
| Barolome, M | 1 |
| May, TW | 1 |
| Dooley, JM | 1 |
| Camfield, PR | 1 |
| Camfield, CS | 1 |
| Gordon, KE | 1 |
| Fraser, AD | 1 |
| Delgado, M | 1 |
| Iannaccone, ST | 1 |
| Forman, LJ | 1 |
| Eggers, CM | 1 |
| Omtzigt, JG | 1 |
| Los, FJ | 1 |
| Lindhout, D | 2 |
| Wagner, ML | 1 |
| Remmel, RP | 1 |
| Graves, NM | 1 |
| Leppik, IE | 1 |
| Villagran, R | 2 |
| Kimura, M | 1 |
| Yoshino, K | 1 |
| Maeoka, Y | 1 |
| Suzuki, N | 1 |
| Fritsch, W | 1 |
| Leach, JP | 1 |
| Blacklaw, J | 3 |
| Jamieson, V | 1 |
| Jones, T | 1 |
| Richens, A | 1 |
| Svinarov, DA | 1 |
| Pippenger, CE | 1 |
| Pienimäki, P | 1 |
| Lampela, E | 1 |
| Hakkola, J | 1 |
| Arvela, P | 1 |
| Raunio, H | 1 |
| Vähäkangas, K | 1 |
| Bernus, I | 1 |
| Dickinson, RG | 1 |
| Hooper, WD | 1 |
| Eadie, MJ | 2 |
| Gidal, BE | 1 |
| Rutecki, P | 1 |
| Shaw, R | 1 |
| Maly, MM | 1 |
| Collins, DM | 1 |
| Pitterle, ME | 1 |
| Besag, FM | 1 |
| Berry, DJ | 1 |
| Pool, F | 1 |
| Newbery, JE | 1 |
| Subel, B | 1 |
| Miura, H | 2 |
| Minkova, GD | 1 |
| Getova, DP | 1 |
| McKauge, L | 1 |
| Tyrer, JH | 1 |
| Bonneton, J | 1 |
| Genton, P | 1 |
| Mesdjian, E | 1 |
| McKee, PJ | 2 |
| Butler, E | 3 |
| Gillham, RA | 3 |
| Meinardi, H | 1 |
| Camfield, P | 1 |
| Hwang, P | 1 |
| Camfield, C | 1 |
| Fraser, A | 1 |
| Soldin, S | 1 |
| al-Quadah, AK | 1 |
| Hartley, R | 3 |
| Aleksandrowicz, J | 1 |
| Bowmer, CJ | 2 |
| Cawood, A | 1 |
| Forsythe, WI | 3 |
| Sunaoshi, W | 1 |
| Takanashi, S | 1 |
| Shirai, H | 1 |
| Hosoda, N | 1 |
| Kaski, M | 1 |
| Heinonen, E | 1 |
| Sivenius, J | 1 |
| Tuominen, J | 1 |
| Anttila, M | 1 |
| McLain, B | 2 |
| Ng, PC | 2 |
| Lucock, MD | 2 |
| Spina, E | 2 |
| Martines, C | 1 |
| Fazio, A | 3 |
| Trio, R | 2 |
| Pisani, F | 3 |
| Tomson, T | 3 |
| Sälke-Treumann, A | 1 |
| Boenigk, HE | 1 |
| Ramsay, RE | 1 |
| McManus, DQ | 1 |
| Guterman, A | 1 |
| Briggle, TV | 1 |
| Vazquez, D | 1 |
| Perchalski, R | 1 |
| Yost, RA | 1 |
| Wong, P | 1 |
| Robbins, DK | 1 |
| Wedlund, PJ | 1 |
| Kuhn, R | 1 |
| Baumann, RJ | 1 |
| Chang, SL | 1 |
| Wang, RB | 1 |
| Liu, LT | 1 |
| Yiu, CH | 1 |
| Chang, TY | 1 |
| Amendola D'Agostino, AM | 1 |
| Ioculano, MP | 1 |
| Oteri, G | 2 |
| Almkvist, O | 1 |
| Nilsson, BY | 1 |
| Svensson, JO | 2 |
| Bertilsson, L | 1 |
| Muñoz, JJ | 1 |
| De Salamanca, RE | 1 |
| Diaz-Obregón, C | 1 |
| Timoneda, FL | 1 |
| Hilton-Brown, P | 1 |
| Williams, N | 1 |
| Wiedmann, K | 1 |
| Larkin, JG | 1 |
| Juergens, U | 1 |
| van Belle, G | 1 |
| Friel, PN | 1 |
| Agbato, OA | 2 |
| Russo, M | 1 |
| Pisani, B | 1 |
| Di Perri, R | 1 |
| Furlanut, M | 1 |
| Montanari, G | 1 |
| Bonin, P | 1 |
| Casara, GL | 1 |
| Santucci, M | 1 |
| Lamontanara, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva[NCT00395499] | 19 participants | Observational | 2001-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for carbamazepine epoxide and Epilepsy
| Article | Year |
|---|---|
Association between EPHX1 polymorphisms and carbamazepine metabolism in epilepsy: a meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Epoxide Hydrolases; Humans; Polymorphism, | 2019 |
Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy.
Topics: Brain Chemistry; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, | 1985 |
15 trials available for carbamazepine epoxide and Epilepsy
| Article | Year |
|---|---|
Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Topics: Acridines; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Therapy, Combination; E | 2011 |
The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure L | 2003 |
Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Child; Child, Preschool; Double-Blind Method; Drug Int | 2004 |
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Haplotypes; Hum | 2005 |
Factors influencing plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic children and adults.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Chromatography, H | 1995 |
Influence of sex, age, weight, and carbamazepine dose on serum concentrations, concentration ratios, and level/dose ratios of carbamazepine and its metabolites.
Topics: Aging; Body Weight; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilep | 1994 |
Effect of felbamate on carbamazepine and its major metabolites.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; | 1993 |
Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites.
Topics: Acetamides; Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Double-Blind Method; Drug Int | 1996 |
Relationships between carbamazepine-diol, carbamazepine-epoxide, and carbamazepine total and free steady-state concentrations in epileptic patients: the influence of age, sex, and comedication.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug | 1996 |
The mechanism of the carbamazepine-valproate interaction in humans.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mi | 1997 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Admini | 2000 |
Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Intera | 2000 |
Dissolution and relative bioavailability of two carbamazepine preparations for children with epilepsy.
Topics: Adolescent; Biological Availability; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Random Al | 1991 |
Monotherapy with conventional and controlled-release carbamazepine: a double-blind, double-dummy comparison in epileptic patients.
Topics: Adult; Carbamazepine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule | 1991 |
Treatment of epilepsy in mentally retarded patients with a slow-release carbamazepine preparation.
Topics: Adolescent; Adult; Carbamazepine; Child; Delayed-Action Preparations; Double-Blind Method; Drug Admi | 1991 |
70 other studies available for carbamazepine epoxide and Epilepsy
| Article | Year |
|---|---|
Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.
Topics: Adult; Anticonvulsants; Benzodiazepines; Biological Availability; Blood-Brain Barrier; Carbamazepine | 2017 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationsh | 2016 |
Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilep | 2016 |
CSF concentrations and serum protein binding of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.
Topics: Adolescent; Adult; Blood Proteins; Carbamazepine; Epilepsy; Humans; Male; Protein Binding; Young Adu | 1976 |
The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation.
Topics: Anticonvulsants; Asian People; Carbamazepine; China; Computer Simulation; Dose-Response Relationship | 2012 |
Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Infant; Isox | 2006 |
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproi | 1984 |
Carbamazepine levels in breast milk.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoenzyme Techniques; Milk, Human; Spectrophotome | 1984 |
Carbamazepine/valproic acid interaction in man and rhesus monkey.
Topics: Adolescent; Adult; Animals; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interaction | 1984 |
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Chromatography, High Pressure Liquid; Dr | 1984 |
Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epil | 1984 |
Carbamazepine-10,11-diol steady-state serum levels and renal excretion during carbamazepine therapy in adults and children.
Topics: Adult; Biotransformation; Carbamazepine; Child; Epilepsy; Female; Humans; Kinetics; Male | 1984 |
Free and total plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients: diurnal fluctuations and relationship with side effects.
Topics: Adult; Aged; Carbamazepine; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; Middle Aged | 1984 |
Fluctuations in salivary carbamazepine and carbamazepine-10,11-epoxide concentrations during the day in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; Saliva | 1983 |
Carbamazepine and its major metabolites in plasma: a summary of eight years of therapeutic drug monitoring.
Topics: Black People; Carbamazepine; Epilepsy; Humans; White People | 1983 |
Carbamazepine 10, 11 epoxide concentrations in epileptics on carbamazepine alone and in combination with other anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans | 1983 |
Carbamazepine and carbamazepine-10,11- epoxide during pregnancy and postnatal period in epileptic mother and their nursed infants: pharmacokinetics and clinical effects.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; | 1983 |
Protein binding of carbamazepine and its epoxide in maternal and fetal plasma at delivery: comparison to other anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Fatty Acids, | 1984 |
Carbamazepine determination in saliva of children: enzyme immunoassay (EMIT) versus high pressure liquid chromatography.
Topics: Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Epilepsy; Humans; Immu | 1982 |
Simultaneous liquid-chromatographic determination of carbamazepine and its epoxide metabolite in plasma.
Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Evaluation Studies as Topic; H | 1982 |
Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11-epoxide in epileptic patients.
Topics: Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Male; Protein Binding; Saliva | 1981 |
Influence of disulfiram on the serum concentration of carbamazepine in patients with epilepsy.
Topics: Adult; Carbamazepine; Disulfiram; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged | 1981 |
Simultaneous liquid chromatographic analysis for carbamazepine and carbamazepine 10,11-epoxide in plasma and saliva by use of double internal standardization.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Saliva | 1980 |
Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children.
Topics: Biotransformation; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dose-Response Relatio | 1995 |
Efficacy of carbamazepine with respect to distribution of carbamazepine and its metabolite 10,11-epoxide in cerebral tumours and paratumorous cortex.
Topics: Adolescent; Adult; Aged; Biopsy; Brain Neoplasms; Carbamazepine; Cerebral Cortex; Child; Epilepsy; F | 1994 |
In vivo binding characteristics of carbamazepine and carbamazepine 10, 11-epoxide to serum proteins in monotherapy adult patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Ag | 1994 |
Six mutagenicity assays in exposure biomonitoring of patients receiving carbamazepine for epilepsy or trigeminal neuralgia.
Topics: Adolescent; Adult; Aged; Biotransformation; Carbamazepine; Case-Control Studies; Cell Division; Chil | 1995 |
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dru | 1994 |
Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in serum, brain tumors and paratumorous cortex: a prospective study of 37 neurosurgically treated epileptic patients.
Topics: Adolescent; Adult; Aged; Biological Availability; Biopsy; Brain Neoplasms; Carbamazepine; Cerebral C | 1994 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuxim | 1993 |
Determination of total and free carbamazepine and the principal metabolites in serum by high-performance liquid chromatography with photodiode-array detection.
Topics: Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Humans; Spectrophotometry, Ult | 1993 |
The 10,11-epoxide-10,11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, comedication, and relation to outcome of pregnancy.
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Carbamazepine; Cohort Studies; Dose-Response Relationsh | 1993 |
In vivo binding characteristics of carbamazepine and carbamazepine-10,11-epoxide to serum proteins in paediatric patients with epilepsy.
Topics: Adolescent; Age Factors; Blood Proteins; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; H | 1993 |
Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum: analysis of autoptic specimens from 51 epileptic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autopsy; Brain Chemistry; Carbamazepine; Child; Child, P | 1993 |
Comparison of equations for predicting bound serum concentrations of carbamazepine and carbamazepine-10, 11-epoxide after polytherapy in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Blood Proteins; Carbamazepine; Child; C | 1995 |
Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hemiplegia; Humans; Thrombocytopenia | 1995 |
Lack of influence of histopathological changes on carbamazepine and carbamazepine-10, 11-epoxide concentrations in the brain cortex of epileptic patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Female; H | 1996 |
Pharmacokinetics of oxcarbazepine and carbamazepine in human placenta.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epilepsy; Fe | 1997 |
Effect of lamotrigine on carbamazepine epoxide/carbamazepine serum concentration ratios in adult patients with epilepsy.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; | 1997 |
Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction?
Topics: Anticonvulsants; Carbamazepine; Child; Diplopia; Dizziness; Dose-Response Relationship, Drug; Drug A | 1998 |
Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hospitalization; H | 1999 |
The epoxide of carbamazepine.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Biotransformation; Carbamazepine; Child; Child, Preschool; | 1979 |
Distribution of carbamazepine and its epoxide in blood compartments in adolescent and adult epileptic patients.
Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Carbamazepine; Chromatography, High Pressure Liquid; | 1992 |
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cognition; Drug Interactions; Epilepsy; Female; Humans; Male; Midd | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
The pharmacology of chewable versus regular carbamazepine in chronically treated children with epilepsy.
Topics: Carbamazepine; Child; Chronic Disease; Epilepsy; Female; Humans; Male; Tablets | 1992 |
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fema | 1991 |
Daily variations in steady-state plasma concentrations of carbamazepine and its metabolites in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Ma | 1991 |
Effect of phenobarbital on the pharmacokinetics of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine.
Topics: Adult; Biological Availability; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Age | 1991 |
Valproic acid-induced carbamazepine-10,11-epoxide toxicity in children and adolescents.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I | 1990 |
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
Topics: Adolescent; Blood Proteins; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Humans; Male | 1990 |
Carbamazepine drug interactions: the influence of concurrent drug therapy on serum concentrations of carbamazepine and its epoxide metabolite.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital | 1990 |
Factors influencing plasma level/dose ratios of carbamazepine and its major metabolites in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Epilepsy; Humans; Regression Analysis; Time Factors | 1990 |
No effect of thioridazine on plasma concentrations of carbamazepine and its active metabolite carbamazepine-10,11-epoxide.
Topics: Adult; Carbamazepine; Epilepsy; Female; Homeostasis; Humans; Male; Middle Aged; Thioridazine | 1990 |
A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients.
Topics: Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Male; Tablets | 1990 |
Carbamazepine-10,11-epoxide in epilepsy. A pilot study.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; | 1990 |
The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Chromatogra | 1990 |
Carbamazepine update.
Topics: Carbamazepine; Diuresis; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Trigeminal Neuralgia | 1989 |
Relationship of intraindividual dose to plasma concentration of carbamazepine: indication of dose-dependent induction of metabolism.
Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male | 1989 |
Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; | 1988 |
Serum concentrations of carbamazepine and its epoxide and diol metabolites in epileptic patients: the influence of dose and comedication.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination | 1987 |
Problem of spurious correlation in the evaluation of steady-state carbamazepine levels using metabolite data.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma | 1986 |
Factors influencing simultaneous concentrations of total and free carbamazepine and carbamazepine-10, 11-epoxide in serum of children with epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, | 1986 |
Total and free serum concentrations of carbamazepine and carbamazepine-10,11-epoxide in children with epilepsy.
Topics: Adolescent; Carbamazepine; Child; Epilepsy; Female; Humans; Male | 1986 |
Carbamazepine-viloxazine interaction in patients with epilepsy.
Topics: Adult; Carbamazepine; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Epilepsy; F | 1986 |
Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1985 |
Lateral gaze nystagmus in carbamazepine-treated epileptic patients: correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Nystagmus, Pathologic; Phenobarbital | 1985 |
Alpha 1-acid glycoprotein concentration and serum protein binding of carbamazepine and carbamazepine-10,11 epoxide in children with epilepsy.
Topics: Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Orosomucoid; Protein | 1985 |