carbamazepine epoxide has been researched along with Epilepsy, Tonic-Clonic in 3 studies
carbamazepine epoxide: metabolite of carbamazepine; RN given refers to unlabeled cpd
carbamazepine-10,11-epoxide : An epoxide and metabolite of carbamazepine.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Fifty-two children between the age of 2 weeks and 15 years were treated with CBZ (mean dosage 17 mg/kg body weight) either as mono- (n = 36) or in polytherapy (n = 16)." | 2.67 | The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence. ( Hannak, D; Haug, C; Korinthenberg, R, 1994) |
| " Mean concentration values also differed significantly, which is explained by a somewhat reduced bioavailability (22% less) of the slow-release formulation." | 2.67 | Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations. ( Arvidsson, J; Eeg-Olofsson, O; Grahn, PA; Gylje, H; Larsson, C; Nilsson, HL; Norén, L; Tonnby, B, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korinthenberg, R | 1 |
| Haug, C | 1 |
| Hannak, D | 1 |
| Spina, E | 1 |
| Avenoso, A | 1 |
| Pollicino, AM | 1 |
| Caputi, AP | 1 |
| Fazio, A | 1 |
| Pisani, F | 1 |
| Eeg-Olofsson, O | 1 |
| Nilsson, HL | 1 |
| Tonnby, B | 1 |
| Arvidsson, J | 1 |
| Grahn, PA | 1 |
| Gylje, H | 1 |
| Larsson, C | 1 |
| Norén, L | 1 |
3 trials available for carbamazepine epoxide and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child Development; Child, Preschool; | 1994 |
Carbamazepine coadministration with fluoxetine or fluvoxamine.
Topics: Adult; Carbamazepine; Depression; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Pa | 1993 |
Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Circadian Rhythm; Delayed-Action Preparations; E | 1990 |