carbamazepine epoxide has been researched along with Epilepsies, Partial in 10 studies
carbamazepine epoxide: metabolite of carbamazepine; RN given refers to unlabeled cpd
carbamazepine-10,11-epoxide : An epoxide and metabolite of carbamazepine.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In adults with focal seizures, adjunctive BRV treatment does not affect plasma concentrations of the evaluated AEDs but increases carbamazepine epoxide metabolite." | 5.30 | Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials. ( Moseley, BD; Otoul, C; Staelens, L; Stockis, A, 2019) |
| "We studied the steady-state pharmacokinetic profile of topiramate (TPM) as a function of dose and the effects of comedication with carbamazepine (CBZ)." | 2.68 | Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy. ( Doose, DR; Kramer, LD; Nayak, RK; Sachdeo, RC; Sachdeo, SK; Walker, SA, 1996) |
| " Fifty-two children between the age of 2 weeks and 15 years were treated with CBZ (mean dosage 17 mg/kg body weight) either as mono- (n = 36) or in polytherapy (n = 16)." | 2.67 | The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence. ( Hannak, D; Haug, C; Korinthenberg, R, 1994) |
| "We evaluated the efficacy, development of adverse effects, and possible correlation between the plasma concentration of carbamazepine (CBZ) and its major metabolite, carbamazepine-10,11-epoxide (CBZ-E), in a group of epileptic patients in whom selective increases in CBZ doses were made." | 2.67 | Carbamazepine and its epoxide: an open study of efficacy and side effects after carbamazepine dose increment in refractory partial epilepsy. ( Baulac, M; Gimenez, F; Laplane, D; Longer, E; Semah, F; Thuillier, A, 1994) |
| " Mean concentration values also differed significantly, which is explained by a somewhat reduced bioavailability (22% less) of the slow-release formulation." | 2.67 | Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations. ( Arvidsson, J; Eeg-Olofsson, O; Grahn, PA; Gylje, H; Larsson, C; Nilsson, HL; Norén, L; Tonnby, B, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moseley, BD | 1 |
| Otoul, C | 1 |
| Staelens, L | 1 |
| Stockis, A | 1 |
| Steinhoff, BJ | 1 |
| Bacher, M | 1 |
| Blickhan, M | 1 |
| Bernedo, V | 1 |
| Dietmann, D | 1 |
| Intravooth, T | 1 |
| Kornmeier, R | 1 |
| Kurth, C | 1 |
| Mahn, P | 1 |
| Schneider, M | 1 |
| Stockinger, J | 1 |
| Staack, AM | 1 |
| Korinthenberg, R | 1 |
| Haug, C | 1 |
| Hannak, D | 1 |
| Semah, F | 1 |
| Gimenez, F | 1 |
| Longer, E | 1 |
| Laplane, D | 1 |
| Thuillier, A | 1 |
| Baulac, M | 1 |
| Gidal, BE | 1 |
| Spencer, NW | 1 |
| Maly, MM | 1 |
| Pitterle, ME | 1 |
| Sachdeo, RC | 1 |
| Sachdeo, SK | 1 |
| Walker, SA | 1 |
| Kramer, LD | 1 |
| Nayak, RK | 1 |
| Doose, DR | 1 |
| Miura, H | 1 |
| Eeg-Olofsson, O | 1 |
| Nilsson, HL | 1 |
| Tonnby, B | 1 |
| Arvidsson, J | 1 |
| Grahn, PA | 1 |
| Gylje, H | 1 |
| Larsson, C | 1 |
| Norén, L | 1 |
| Benetello, P | 1 |
| Furlanut, M | 1 |
| Perlotto, N | 1 |
| Rapeport, WG | 1 |
1 review available for carbamazepine epoxide and Epilepsies, Partial
| Article | Year |
|---|---|
Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy.
Topics: Brain Chemistry; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, | 1985 |
6 trials available for carbamazepine epoxide and Epilepsies, Partial
| Article | Year |
|---|---|
Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; | 2019 |
The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child Development; Child, Preschool; | 1994 |
Carbamazepine and its epoxide: an open study of efficacy and side effects after carbamazepine dose increment in refractory partial epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; Female; Huma | 1994 |
Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy.
Topics: Adult; Anticonvulsants; Biological Availability; Carbamazepine; Dose-Response Relationship, Drug; Dr | 1996 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Admini | 2000 |
Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Circadian Rhythm; Delayed-Action Preparations; E | 1990 |
3 other studies available for carbamazepine epoxide and Epilepsies, Partial
| Article | Year |
|---|---|
Is brivaracetam-induced elevation of carbamazepine-epoxide levels common and clinically relevant? - A case series.
Topics: Adult; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Pyrrolidinones; Seizur | 2020 |
Evaluation of carbamazepine and carbamazepine-epoxide protein binding in patients undergoing epilepsy surgery.
Topics: Adult; Blood Proteins; Carbamazepine; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; | 1996 |
Carbamazepine and carbamazepine-epoxide serum concentrations in some resistant cases of complex partial seizures.
Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsies, Partial; Female; Hum | 1989 |