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carbamazepine and Vitamin D Deficiency

carbamazepine has been researched along with Vitamin D Deficiency in 12 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)

Research Excerpts

ExcerptRelevanceReference
"To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls."7.88Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018)
" Under carbamazepine monotherapy, the patient presented hypoparathyroidism accompanied by severe hypocalcemia."3.91Familial congenital choanal atresia with GATA3 associated hypoparathyroidism-deafness-renal dysplasia syndrome unidentified on auditory brainstem response. ( Kita, M; Kuwata, Y; Usui, T, 2019)
"To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls."3.88Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018)
" The relationship between chronic use of carbamazepine and vitamin D levels has been studied, but no comprehensive review to inform practitioners and policymakers is currently available."2.72Impact of carbamazepine on vitamin D levels: A meta-analysis. ( Brennan, L; LoPinto-Khoury, C; Mintzer, S, 2021)
"Therefore, in children with a seizure disorder on long-term valproate therapy, 25-OH-Vit D levels should be monitored and appropriate supplementation implemented if levels are deficient."2.61Valproate decreases vitamin D levels in pediatric patients with epilepsy. ( Chen, F; Guo, H; Hu, Y; Jing, X; Li, G; Lu, XP; Sun, F; Sun, J; Wang, T; Wen, X; Xu, Z, 2019)
"For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0."1.40Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
LoPinto-Khoury, C1
Brennan, L1
Mintzer, S2
Sreedharan, M1
Devadathan, K1
Mohammed Kunju, PA1
Sasidharan, B1
Pillai, JP1
Vasumathy Amma, MA1
Muthubeevi, S1
Kita, M1
Kuwata, Y1
Usui, T1
Xu, Z1
Jing, X1
Li, G1
Sun, J1
Guo, H1
Hu, Y1
Sun, F1
Wen, X1
Chen, F1
Wang, T1
Lu, XP1
Awa, HD1
Chelo, D1
Kinkela, MN1
Ndombo, PO1
Baek, JH1
Seo, YH1
Kim, GH1
Kim, MK1
Eun, BL1
Rokan, Z1
Kealey, WD1
Boppana, P1
Toguri, J1
DeSantis, A1
Verrotti, A1
Matricardi, S1
Manco, R1
Chiarelli, F1
Rajantie, J1
Lamberg-Allardt, C1
Wilska, M1
Goraya, JS1
Gupta, PN1
Gupta, RK1
Bahadur, R1
Parmar, VR1
Varkey, K1
Raman, PT1
Bhaktaviziam, A1
Taori, GM1

Reviews

2 reviews available for carbamazepine and Vitamin D Deficiency

ArticleYear
Impact of carbamazepine on vitamin D levels: A meta-analysis.
    Epilepsy research, 2021, Volume: 178

    Topics: Carbamazepine; Epilepsy; Humans; Vitamin D; Vitamin D Deficiency; Vitamins

2021
Valproate decreases vitamin D levels in pediatric patients with epilepsy.
    Seizure, 2019, Volume: 71

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Valproic Acid

2019

Other Studies

10 other studies available for carbamazepine and Vitamin D Deficiency

ArticleYear
Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy.
    Indian pediatrics, 2018, Apr-15, Volume: 55, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sec

2018
Familial congenital choanal atresia with GATA3 associated hypoparathyroidism-deafness-renal dysplasia syndrome unidentified on auditory brainstem response.
    Auris, nasus, larynx, 2019, Volume: 46, Issue:5

    Topics: Adult; Anticonvulsants; Audiometry, Pure-Tone; Carbamazepine; Child; Choanal Atresia; Epilepsy; Evok

2019
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
    The Pan African medical journal, 2013, Volume: 14

    Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human

2013
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
    Yonsei medical journal, 2014, Volume: 55, Issue:2

    Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr

2014
Osteomalacia: a forgotten cause of fractures in the elderly.
    BMJ case reports, 2015, Feb-09, Volume: 2015

    Topics: Aged; Anticonvulsants; Carbamazepine; Delayed Diagnosis; Diet; Epilepsy; Femoral Neck Fractures; Hum

2015
Vitamin D levels and bone turnover in epilepsy patients taking carbamazepine or oxcarbazepine.
    Epilepsia, 2006, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone and Bones; Bone Res

2006
Bone metabolism and vitamin D levels in carbamazepine-treated patients.
    Epilepsia, 2006, Volume: 47, Issue:9

    Topics: Anticonvulsants; Bone and Bones; Bone Development; Bone Resorption; Carbamazepine; Dose-Response Rel

2006
Does carbamazepine treatment lead to a need of extra vitamin D in some mentally retarded children?
    Acta paediatrica Scandinavica, 1984, Volume: 73, Issue:3

    Topics: Adolescent; Adult; Alkaline Phosphatase; Calcifediol; Calcium; Carbamazepine; Child; Female; Humans;

1984
Anticonvulsant induced osteomalacia.
    Indian pediatrics, 2000, Volume: 37, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Male; Osteomalacia; Ph

2000
Osteomalacia due to phenytoin sodium. A case report with review of literature.
    Journal of the neurological sciences, 1973, Volume: 19, Issue:3

    Topics: Adult; Bone and Bones; Calcium; Carbamazepine; Clavicle; Deficiency Diseases; Female; Folic Acid; Hu

1973