carbamazepine has been researched along with Hypothyroidism in 29 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation." | 7.85 | A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia. ( Hasebe, N; Kawamura, Y; Ota, H; Sato, N, 2017) |
| "OBJECTIVES - While carbamazepine (CBZ) decreases thyroid hormone concentrations it rarely causes hypothyroidism." | 7.74 | Carbamazepine and risk of hypothyroidism: a prospective study. ( Horacek, J; Simko, J, 2007) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 7.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| "Carbamazepine (CBZ) is a medication used commonly in epilepsy." | 5.62 | Carbamazepine drug effect simulating biochemical central hypothyroidism in a patient with Bardet-Biedl syndrome. ( Kishlyansky, D; Kline, G, 2021) |
| "Oxcarbazepine was developed to attempt to reduce the side effects that have traditionally been observed with antiepileptic drugs that induce the hepatic enzyme system." | 5.33 | Central hypothyroidism with oxcarbazepine therapy. ( Carney, P; Miller, J, 2006) |
| "This investigation evaluated the relationship between changes in thyroid indices and mood stability during lithium and carbamazepine prophylaxis for bipolar disorder." | 5.09 | Association between lower serum free T4 and greater mood instability and depression in lithium-maintained bipolar patients. ( Ali, SO; Bryan, AL; Denicoff, KD; Frye, MA; Leverich, GS; Luckenbaugh, D; Post, RM; Smith-Jackson, EE, 1999) |
| "Eight patients taking anticonvulsant medication and four patients with hypothalamic hypothyroidism were given thyroxine, 150-200 micrograms daily for 3 months, or placebo." | 5.07 | Thyroxine treatment increases circulating levels of insulin-like growth factor binding protein-1: a placebo-controlled study. ( Angervo, M; Leinonen, P; Seppälä, M; Tiihonen, M; Välimäki, M, 1993) |
| "We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation." | 3.85 | A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia. ( Hasebe, N; Kawamura, Y; Ota, H; Sato, N, 2017) |
| " Both administrations of CBZ caused a hypothyroidism in dams and fetuses whereas the decreases in serum thyroxine (T4) and triiodothyronine (T3) and increases in serum thyrotropin (TSH) levels were highly significant (LSD; P <0." | 3.85 | Maternal carbamazepine alters fetal neuroendocrine-cytokines axis. ( Ahmed, RG; El-Gareib, AW, 2017) |
| " In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism." | 3.80 | Transient hypothyroidism induced by anticonvulsant agents. ( Krysiak, R; Stojko, R, 2014) |
| "OBJECTIVES - While carbamazepine (CBZ) decreases thyroid hormone concentrations it rarely causes hypothyroidism." | 3.74 | Carbamazepine and risk of hypothyroidism: a prospective study. ( Horacek, J; Simko, J, 2007) |
| "Carbamazepine and valproic acid are effective antiepileptic drugs for treating many types of epilepsy." | 3.71 | Thyroid hormones in epileptic children receiving carbamazepine and valproic acid. ( Basciani, F; Chiarelli, F; Morgese, G; Morresi, S; Verrotti, A, 2001) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 3.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| " Addition of carbamazepine to lithium can counteract lithium-induced subclinical hypothyroidism, possibly improving prophylactic efficacy in recurrent affective disorders." | 3.69 | Six-year follow-up of thyroid function during lithium treatment. ( Bocchetta, A; Cherchi, A; Del Zompo, M; Derai, R; Loviselli, A; Mossa, P; Velluzzi, F, 1996) |
| "Two patients on long-term anti-epileptic treatment, one with both phenytoin and carbamazepine, the other with carbamazepine, developed clinical hypothyroidism." | 3.66 | Hypothyroidism induced by anti-epileptic therapy. ( Aanderud, S; Strandjord, RE, 1980) |
| "Carbamazepine (CBZ) is a medication used commonly in epilepsy." | 1.62 | Carbamazepine drug effect simulating biochemical central hypothyroidism in a patient with Bardet-Biedl syndrome. ( Kishlyansky, D; Kline, G, 2021) |
| "Carbamazepine (CBZ) is a commonly used antiepileptic that is metabolized by CYP3A isoforms." | 1.38 | Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. ( Jang, HC; Lee, EK; Lee, YK; Moore, DD; Park, DJ; Park, YJ, 2012) |
| "The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively." | 1.37 | Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011) |
| "Oxcarbazepine was developed to attempt to reduce the side effects that have traditionally been observed with antiepileptic drugs that induce the hepatic enzyme system." | 1.33 | Central hypothyroidism with oxcarbazepine therapy. ( Carney, P; Miller, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Kishlyansky, D | 1 |
| Kline, G | 1 |
| Ota, H | 1 |
| Kawamura, Y | 1 |
| Sato, N | 1 |
| Hasebe, N | 1 |
| Turan, MI | 1 |
| Cayir, A | 1 |
| Ozden, O | 1 |
| Tan, H | 1 |
| Krysiak, R | 1 |
| Stojko, R | 1 |
| Ahmed, RG | 1 |
| El-Gareib, AW | 1 |
| Visser, WE | 1 |
| de Rijke, YB | 1 |
| van Toor, H | 1 |
| Visser, TJ | 1 |
| Park, YJ | 1 |
| Lee, EK | 1 |
| Lee, YK | 1 |
| Park, DJ | 1 |
| Jang, HC | 1 |
| Moore, DD | 1 |
| Miller, J | 1 |
| Carney, P | 1 |
| Simko, J | 1 |
| Horacek, J | 1 |
| Hirfanoglu, T | 1 |
| Serdaroglu, A | 1 |
| Camurdan, O | 1 |
| Cansu, A | 1 |
| Bideci, A | 1 |
| Cinaz, P | 1 |
| Gucuyener, K | 1 |
| Joffe, RT | 1 |
| Roy-Byrne, PP | 1 |
| Udhe, TW | 1 |
| Post, RM | 3 |
| Maheshwari, MC | 1 |
| Kouchupillai, N | 1 |
| Jailkhani, BL | 1 |
| Gupta, SK | 1 |
| Aanderud, S | 2 |
| Myking, OL | 1 |
| Strandjord, RE | 2 |
| Tiihonen, M | 2 |
| Liewendahl, K | 1 |
| Waltimo, O | 1 |
| Ojala, M | 1 |
| Välimäki, M | 2 |
| Angervo, M | 1 |
| Leinonen, P | 1 |
| Seppälä, M | 1 |
| Del Zompo, M | 3 |
| Bocchetta, A | 4 |
| Loviselli, A | 4 |
| Martino, E | 2 |
| Ketter, TA | 1 |
| Gonzalez, IG | 1 |
| Martin Luquero, M | 1 |
| Marcos Martinez, L | 1 |
| Gargallo Fernandez, MA | 1 |
| Cherchi, A | 1 |
| Mossa, P | 2 |
| Velluzzi, F | 3 |
| Derai, R | 1 |
| Shimizu, E | 1 |
| Kodama, K | 1 |
| Sakamoto, T | 1 |
| Komatsu, N | 1 |
| Yamanouchi, N | 1 |
| Okada, S | 1 |
| Sato, T | 1 |
| Valle, J | 1 |
| Ayuso-Gutierrez, JL | 1 |
| Abril, A | 1 |
| Ayuso-Mateos, JL | 1 |
| Frye, MA | 1 |
| Denicoff, KD | 1 |
| Bryan, AL | 1 |
| Smith-Jackson, EE | 1 |
| Ali, SO | 1 |
| Luckenbaugh, D | 1 |
| Leverich, GS | 1 |
| Eirís-Puñal, J | 1 |
| Del Río-Garma, M | 1 |
| Del Río-Garma, MC | 1 |
| Lojo-Rocamonde, S | 1 |
| Novo-Rodríguez, I | 1 |
| Castro-Gago, M | 1 |
| Verrotti, A | 1 |
| Basciani, F | 1 |
| Morresi, S | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Dubovsky, SL | 1 |
| Mariotti, S | 1 |
| Zompo, MD | 1 |
| Bernardi, F | 1 |
| Burrai, C | 1 |
| Pedditzi, M | 1 |
| Bauer, MS | 1 |
| Whybrow, PC | 1 |
| Winokur, A | 1 |
| De Luca, F | 1 |
| Arrigo, T | 1 |
| Pandullo, E | 1 |
| Siracusano, MF | 1 |
| Benvenga, S | 1 |
| Trimarchi, F | 1 |
1 review available for carbamazepine and Hypothyroidism
| Article | Year |
|---|---|
Rapid cycling bipolar disease: new concepts and treatments.
Topics: Anticonvulsants; Bipolar Disorder; Calcium; Calcium Channel Blockers; Carbamazepine; Combined Modali | 2001 |
4 trials available for carbamazepine and Hypothyroidism
| Article | Year |
|---|---|
Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypot | 2007 |
Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial.
Topics: Adult; Age Distribution; Anticonvulsants; Carbamazepine; Comorbidity; Cross-Over Studies; Double-Bli | 1995 |
Thyroxine treatment increases circulating levels of insulin-like growth factor binding protein-1: a placebo-controlled study.
Topics: Adult; Aged; Carbamazepine; Carrier Proteins; Female; Humans; Hypothyroidism; Insulin-Like Growth Fa | 1993 |
Association between lower serum free T4 and greater mood instability and depression in lithium-maintained bipolar patients.
Topics: Affect; Bipolar Disorder; Carbamazepine; Comorbidity; Double-Blind Method; Drug Therapy, Combination | 1999 |
24 other studies available for carbamazepine and Hypothyroidism
| Article | Year |
|---|---|
Carbamazepine drug effect simulating biochemical central hypothyroidism in a patient with Bardet-Biedl syndrome.
Topics: Adult; Bardet-Biedl Syndrome; Carbamazepine; Humans; Hypothyroidism; Male; Pharmaceutical Preparatio | 2021 |
A Carbamazepine-induced Brugada-type Electrocardiographic Pattern in a Patient with Schizophrenia.
Topics: Brugada Syndrome; Carbamazepine; Drug Therapy, Combination; Electrocardiography; Humans; Hypothyroid | 2017 |
An examination of the mutual effects of valproic acid, carbamazepine, and phenobarbital on 25-hydroxyvitamin D levels and thyroid function tests.
Topics: Anticonvulsants; Carbamazepine; Child; Female; Humans; Hypothyroidism; Male; Phenobarbital; Thyroid | 2014 |
Transient hypothyroidism induced by anticonvulsant agents.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm | 2014 |
Maternal carbamazepine alters fetal neuroendocrine-cytokines axis.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebellum; Cytokines; Female; Fetus; Growth Hormone; Hypot | 2017 |
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy, | 2011 |
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Constitutive Androstane Rece | 2012 |
Central hypothyroidism with oxcarbazepine therapy.
Topics: Adolescent; Anticonvulsants; Body Height; Carbamazepine; Child; Dose-Response Relationship, Drug; Fe | 2006 |
Carbamazepine and risk of hypothyroidism: a prospective study.
Topics: Adult; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Down-Regulation; Epilepsy; Humans; Hyp | 2007 |
Thyroid function and affective illness: a reappraisal.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Carbamazepine; Depressive Disorder; Electroconvu | 1984 |
Effect of carbamazepine & its combinations on thyroid functions in epileptics.
Topics: Adolescent; Adult; Carbamazepine; Child; Epilepsy; Female; Humans; Hypothyroidism; Male; Thyroid Hor | 1984 |
The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine.
Topics: Adult; Carbamazepine; Female; Humans; Hypothyroidism; Male; Middle Aged; Thyrotropin; Thyroxine; Thy | 1981 |
Hypothyroidism induced by anti-epileptic therapy.
Topics: Aged; Carbamazepine; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin | 1980 |
Thyroid function during carbamazepine.
Topics: Carbamazepine; Humans; Hypothyroidism; Mood Disorders; Thyroid Function Tests; Thyroid Hormones; Thy | 1994 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E | 1995 |
Six-year follow-up of thyroid function during lithium treatment.
Topics: Antibodies; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Drug Therapy, Combination; Female; | 1996 |
Recovery from neuroendocrinological abnormalities and frontal hypoperfusion after remission in a case with rapid cycling bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clonazepam; Dexamethasone; Drug Therapy, Combinati | 1997 |
Evaluation of thyroid function in lithium-naive bipolar patients.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Carbamazepine; Female; Humans; Hypothyroidism; Lithium; M | 1999 |
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyro | 1999 |
Thyroid hormones in epileptic children receiving carbamazepine and valproic acid.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Drug Interactions; Drug The | 2001 |
Ten-year follow-up of thyroid function in lithium patients.
Topics: Antimanic Agents; Autoantibodies; Carbamazepine; Confidence Intervals; Drug Therapy, Combination; Fe | 2001 |
The course of thyroid abnormalities during lithium treatment: a two-year follow-up study.
Topics: Adult; Antibodies; Antibody Formation; Carbamazepine; Female; Follow-Up Studies; Humans; Hypothyroid | 1992 |
Rapid cycling bipolar affective disorder. I. Association with grade I hypothyroidism.
Topics: Adult; Aged; Bipolar Disorder; Carbamazepine; Female; Humans; Hypothyroidism; Lithium; Lithium Carbo | 1990 |
Changes in thyroid function tests induced by 2 month carbamazepine treatment in L-thyroxine-substituted hypothyroid children.
Topics: Carbamazepine; Child; Child, Preschool; Congenital Hypothyroidism; Epilepsies, Partial; Female; Huma | 1986 |