carbamazepine has been researched along with Genetic Predisposition in 89 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ABCB1 polymorphisms were previously demonstrated to be associated with the metabolism and resistance of carbamazepine (CBZ) in epilepsy, but the results still remained controversial." | 9.12 | Association of ABCB1 polymorphisms with carbamazepine metabolism and resistance in epilepsy: A meta-analysis. ( Fan, YX; He, GH; Huang, YH; Meng, JR; Meng, R; Wang, P; Yin, SJ; Zhang, Z; Zhou, T, 2021) |
| "This study aimed to investigate the prevalence and association of HLA-B*15:02 with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (CBZ-SJS/TEN) in the Indian population in Malaysia, which mostly originated from Southern India." | 8.90 | HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis. ( Khor, AH; Lim, KS; Ng, CC; Tan, CT; Wong, SM, 2014) |
| " The specific MHC molecules implicated in hypersensitivity have been identified; for example, HLA-B*5701 in abacavir-induced drug hypersensitivity and HLA-B*1502 in carbamazepine-induced Stevens-Johnson syndrome." | 8.88 | T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction. ( Chen, YT; Ko, TM, 2012) |
| "We constructed a Markov model in a hypothetical cohort of adult Asian patients with epilepsy in the United States being considered for carbamazepine to investigate the cost-effectiveness of two alternative strategies: (1) no HLA-B*1502 gene allele screening and using carbamazepine and (2) HLA-B*1502 gene allele screening and starting levetiracetam in the case of a positive screen." | 7.91 | Cost-effectiveness of screening for HLA-B*1502 prior to initiation of carbamazepine in epilepsy patients of Asian ancestry in the United States. ( Choi, H; Mohit, B, 2019) |
| "Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)." | 7.85 | Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype. ( Cavallari, LH; Kristin, E; Mahasirimongkol, S; Menaldi, SL; Prayuni, K; Sachrowardi, Q; Suyatna, FD; Wichukchinda, N; Yuliwulandari, R, 2017) |
| "Screening for the HLA-B*15:02 allele has been recommended to prevent carbamazepine (CBZ) - induced Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in individuals with Asian ancestry." | 7.83 | Validation of a novel real-time PCR assay for detection of HLA-B*15:02 allele for prevention of carbamazepine - Induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis in individuals of Asian ancestry. ( Chu, HC; Do, NT; Fernando, SL; Fulton, RB; Le, HT; Li, J; Nguyen, DV; Tran, TT; Vidal, C, 2016) |
| "Anticonvulsants such as carbamazepine and phenytoin are associated with adverse skin reactions ranging from maculopapular exanthems to more severe reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome and toxic epidermal necrolysis." | 7.80 | Presence of the HLA-A*3101 allele in a familial case of drug reaction with eosinophilia and systemic symptoms, secondary to carbamazepine. ( Anjum, N; Ardern-Jones, M; Cooper, HL; Polak, ME, 2014) |
| "This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China." | 7.79 | Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China. ( He, XJ; He, XL; Jian, LY; Miao, LY; Sun, XJ; Wu, Y; Xu, YY; Zhao, LM, 2013) |
| "Previous studies have demonstrated a strong association between carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (CBZ-induced SJS/TEN) and HLA-B*1502 in Chinese, and HLA-A*3101 but not HLA-B*1502 in Caucasians and Japanese." | 7.78 | Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502? ( Gao, MM; Liao, WP; Liu, XR; Min, FL; Qin, B; Shi, YW; Wang, Q; Zhou, JQ; Zou, X, 2012) |
| "Carbamazepine (CBZ), a frequently used anticonvulsant drug, is one of the most common causes of life-threatening cutaneous adverse drug reactions such as toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS)." | 7.77 | Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population. ( Chang, CC; Hussein, SH; Murad, S; Too, CL, 2011) |
| "A case of severe hypersensitivity syndrome, triggered by carbamazepine in the presence of a concomitant active human herpes virus (HHV) 6 and 7 infection is described." | 7.75 | Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient. ( Barbi, E; Bartoli, F; Calligaris, L; Carrozzi, M; De Iudicibus, S; Decorti, G; Marchetti, F; Marino, S; Stocco, G; Ventura, A, 2009) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 7.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "The antiepileptic drug carbamazepine produces dose related anticonvulsant effects in genetically epilepsy-prone rats (GEPRs) and most other animal seizure models." | 7.69 | Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. ( Dailey, JW; Jobe, PC; Li, MY; Reith, ME; Yan, QS, 1997) |
| "Carbamazepine (CBZ) is an FDA-approved anticonvulsant that is widely used to treat epilepsy, bipolar disorder, trigeminal neuralgia and chronic pain." | 5.72 | Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome. ( Attapong, J; Chomean, S; Kaset, C; Nakkam, N; Tassaneeyakul, W, 2022) |
| "We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein." | 5.13 | Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey. ( Bebek, N; Cine, N; Gul, G; Ozgon, GO, 2008) |
| "ABCB1 polymorphisms were previously demonstrated to be associated with the metabolism and resistance of carbamazepine (CBZ) in epilepsy, but the results still remained controversial." | 5.12 | Association of ABCB1 polymorphisms with carbamazepine metabolism and resistance in epilepsy: A meta-analysis. ( Fan, YX; He, GH; Huang, YH; Meng, JR; Meng, R; Wang, P; Yin, SJ; Zhang, Z; Zhou, T, 2021) |
| "This study aimed to investigate the prevalence and association of HLA-B*15:02 with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (CBZ-SJS/TEN) in the Indian population in Malaysia, which mostly originated from Southern India." | 4.90 | HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis. ( Khor, AH; Lim, KS; Ng, CC; Tan, CT; Wong, SM, 2014) |
| " The specific MHC molecules implicated in hypersensitivity have been identified; for example, HLA-B*5701 in abacavir-induced drug hypersensitivity and HLA-B*1502 in carbamazepine-induced Stevens-Johnson syndrome." | 4.88 | T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction. ( Chen, YT; Ko, TM, 2012) |
| " A strong genetic association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown in Han Chinese patients." | 4.86 | Genetic predisposition of life-threatening antiepileptic-induced skin reactions. ( Chen, YT; Chung, WH; Hung, SI, 2010) |
| " The genetic associations can be drug specific, such as HLA-B*1502 being associated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), HLA-B*5701 with abacavir hypersensitivity and HLA-B*5801 with allopurinol-induced severe cutaneous adverse reactions." | 4.84 | Human leukocyte antigens and drug hypersensitivity. ( Chen, YT; Chung, WH; Hung, SI, 2007) |
| "This study revealed the higher risk of cardiac arrhythmias persists long term in people with epilepsy, especially among those using carbamazepine and valproic acid." | 4.31 | Epilepsy and long-term risk of arrhythmias. ( Cai, J; Feng, Z; Huang, P; Liu, P; Lu, J; Lu, Y; Tang, H; Wang, J; Yang, G; Yang, Y; Yu, Q; Yuan, H, 2023) |
| "Carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele." | 4.02 | Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model. ( Cavallari, LH; Hao, J; Kristin, E; Mahasirimongkol, S; Mitropoulou, C; Patrinos, GP; Prahasto, ID; Prayuni, K; Shin, JG; Snyder, SR; Suyatna, FD; Williams, MS; Yuliwulandari, R, 2021) |
| "We constructed a Markov model in a hypothetical cohort of adult Asian patients with epilepsy in the United States being considered for carbamazepine to investigate the cost-effectiveness of two alternative strategies: (1) no HLA-B*1502 gene allele screening and using carbamazepine and (2) HLA-B*1502 gene allele screening and starting levetiracetam in the case of a positive screen." | 3.91 | Cost-effectiveness of screening for HLA-B*1502 prior to initiation of carbamazepine in epilepsy patients of Asian ancestry in the United States. ( Choi, H; Mohit, B, 2019) |
| "Due to the significant risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the use of carbamazepine is not recommended in patients carrying the human leukocyte antigen B (HLA-B) *15:02 allele." | 3.88 | External quality assessment for laboratory testing of HLA-B*15:02 allele in relation to carbamazepine therapy. ( Han, Y; Li, J; Lin, G; Xie, J; Zhang, K, 2018) |
| "Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)." | 3.85 | Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype. ( Cavallari, LH; Kristin, E; Mahasirimongkol, S; Menaldi, SL; Prayuni, K; Sachrowardi, Q; Suyatna, FD; Wichukchinda, N; Yuliwulandari, R, 2017) |
| "To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese and Thai)." | 3.85 | Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians. ( Chang, PY; Chang, WC; Chang, YC; Chen, CB; Chen, DP; Chen, MJ; Chen, YJ; Chiu, TM; Chu, CY; Chung, WH; Ho, HC; Hsiao, YH; Hsih, MS; Hsu, CK; Hsu, CN; Hui, RC; Hung, SI; Jorns, TP; Kao, PH; Kuo, KL; Kuo, TT; Lee, HE; Lin, CY; Lin, JY; Lin, YJ; Lu, CW; Ng, CY; Su, SC; Sukasem, C; Sun, PL; Tassaneeyakul, W; Weng, YC; Wu, CY; Wu, T; Wu, TL; Yang, CH; Yang, CS; Yang, CY, 2017) |
| "HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations." | 3.85 | A study of HLA-B*15:02 in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN. ( Chen, Q; Ji, X; Jiang, L; Li, L; Liu, Z; Ou, GJ; Su, PC; Wang, J; Yu, H, 2017) |
| "Screening for the HLA-B*15:02 allele has been recommended to prevent carbamazepine (CBZ) - induced Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in individuals with Asian ancestry." | 3.83 | Validation of a novel real-time PCR assay for detection of HLA-B*15:02 allele for prevention of carbamazepine - Induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis in individuals of Asian ancestry. ( Chu, HC; Do, NT; Fernando, SL; Fulton, RB; Le, HT; Li, J; Nguyen, DV; Tran, TT; Vidal, C, 2016) |
| "Previous studies have demonstrated a strong association between carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and HLA-B*1502 in Han Chinese." | 3.80 | Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China. ( He, XL; Hu, JS; Liu, ZS; Mao, B; Sun, D; Wu, GF; Wu, SH; Xiang, HH; Yu, CH, 2014) |
| "Anticonvulsants such as carbamazepine and phenytoin are associated with adverse skin reactions ranging from maculopapular exanthems to more severe reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome and toxic epidermal necrolysis." | 3.80 | Presence of the HLA-A*3101 allele in a familial case of drug reaction with eosinophilia and systemic symptoms, secondary to carbamazepine. ( Anjum, N; Ardern-Jones, M; Cooper, HL; Polak, ME, 2014) |
| "1249G>A GA genotype were significantly associated with carbamazepine/oxcarbamazepine (CBZ/OXC)-resistant epilepsy (p =0." | 3.80 | Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy. ( Hong, Z; Ma, CL; Wu, XY; Wu, ZY; Zheng, J; Zhong, MK, 2014) |
| "Carbamazepine (CBZ) is broadly used for the treatment of epilepsy, neuropathic pain and other neurological diseases, owing to its effectiveness and low price." | 3.79 | Cost minimization of HLA-B*1502 screening before prescribing carbamazepine in Thailand. ( Jitpimolmard, J; Jitpimolmard, S; Sawanyawisuth, K; Tiamkao, S, 2013) |
| "This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China." | 3.79 | Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China. ( He, XJ; He, XL; Jian, LY; Miao, LY; Sun, XJ; Wu, Y; Xu, YY; Zhao, LM, 2013) |
| "The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ)." | 3.79 | HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children. ( Amstutz, U; Carleton, BC; Castro-Pastrana, LI; Hayden, MR; Rieder, MJ; Ross, CJ; Shear, NH, 2013) |
| "Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT)." | 3.78 | Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. ( Dong, D; Finkelstein, EA; Sung, C, 2012) |
| "Previous studies have demonstrated a strong association between carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (CBZ-induced SJS/TEN) and HLA-B*1502 in Chinese, and HLA-A*3101 but not HLA-B*1502 in Caucasians and Japanese." | 3.78 | Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502? ( Gao, MM; Liao, WP; Liu, XR; Min, FL; Qin, B; Shi, YW; Wang, Q; Zhou, JQ; Zou, X, 2012) |
| "Carbamazepine (CBZ), a frequently used anticonvulsant drug, is one of the most common causes of life-threatening cutaneous adverse drug reactions such as toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS)." | 3.77 | Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population. ( Chang, CC; Hussein, SH; Murad, S; Too, CL, 2011) |
| "Twenty-four patients who had developed carbamazepine-induced SCAR (7 Stevens-Johnson syndrome (SJS), 17 drug hypersensitivity syndrome (HSS)), 50 carbamazepine-tolerant controls from the Korean Pharmacogenetic Adverse Drug Reaction Research Network and data of 485 Korean general population from a previously published study were recruited." | 3.77 | Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans. ( Chang, YS; Cho, SH; Jee, YK; Kang, HR; Kim, SH; Lee, KW; Lee, SM; Min, KU; Park, HW; Park, SH; Song, WJ, 2011) |
| "Carbamazepine (CBZ) has been reported as the most common culprit drug for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in several Asian countries including Thailand." | 3.76 | Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population. ( Aungaree, T; Auvichayapat, N; Chen, P; Chen, WH; Choonhakarn, C; Jantararoungtong, T; Khunarkornsiri, U; Konyoung, P; Kulkantrakorn, K; Lin, SY; Pavakul, K; Phonhiamhan, S; Piyatrakul, N; Pongpakdee, S; Tassaneeyakul, W; Tiamkao, S; Yodnopaglaw, P, 2010) |
| "A case of severe hypersensitivity syndrome, triggered by carbamazepine in the presence of a concomitant active human herpes virus (HHV) 6 and 7 infection is described." | 3.75 | Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient. ( Barbi, E; Bartoli, F; Calligaris, L; Carrozzi, M; De Iudicibus, S; Decorti, G; Marchetti, F; Marino, S; Stocco, G; Ventura, A, 2009) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 3.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)." | 3.74 | Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007) |
| "The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)." | 3.73 | Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. ( Chang, YT; Chen, GS; Chen, WC; Chen, WH; Chen, YT; Chung, WH; Fang, WH; Hsiao, PF; Hu, SL; Huang, YL; Hung, SI; Jee, SH; Lee, WR; Lin, JJ; Lou, YH; Shih, HY; Wei, CY; Wong, TW; Wu, MT, 2006) |
| "The antiepileptic drug carbamazepine produces dose related anticonvulsant effects in genetically epilepsy-prone rats (GEPRs) and most other animal seizure models." | 3.69 | Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. ( Dailey, JW; Jobe, PC; Li, MY; Reith, ME; Yan, QS, 1997) |
| "Carbamazepine (CBZ) is a wildly used anti-epileptic drug (AED)." | 2.72 | Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis. ( Hu, T; Liu, J; Tian, T; Zeng, X, 2021) |
| "Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs)." | 2.50 | HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review. ( Chen, CH; Chen, WL; Cheng, CY; Chung, WH; Deng, ST; Su, SC, 2014) |
| "However, the genetic susceptibility and the exact pathogenesis were not clear until the recent studies." | 2.46 | Genetic markers and danger signals in stevens-johnson syndrome and toxic epidermal necrolysis. ( Chung, WH; Hung, SI, 2010) |
| "Neural tube defects (NTDs), including spina bifida and anencephaly, are common congenital malformations that occur when the neural tube fails to achieve proper closure during early embryogenesis." | 2.42 | Pathobiology and genetics of neural tube defects. ( Finnell, RH; Gould, A; Spiegelstein, O, 2003) |
| "Carbamazepine (CBZ) is an FDA-approved anticonvulsant that is widely used to treat epilepsy, bipolar disorder, trigeminal neuralgia and chronic pain." | 1.72 | Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome. ( Attapong, J; Chomean, S; Kaset, C; Nakkam, N; Tassaneeyakul, W, 2022) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions." | 1.72 | Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications. ( Anderson, A; Baum, L; Chen, Z; Cherny, S; Ding, JH; Kwan, P; Liao, WP; Lim, KS; Mullan, KA; Ng, CC; Petrovski, S; Sham, PC; Shi, YW, 2022) |
| "Refractory seizures occurred in the early neonatal period with similar seizure type, including tonic features, apnea, and desaturation." | 1.46 | A Distinctive Ictal Amplitude-Integrated Electroencephalography Pattern in Newborns with Neonatal Epilepsy Associated with KCNQ2 Mutations. ( Brilstra, E; Cilio, MR; de Vries, LS; Mendes Ribeiro, J; Striano, P; Vilan, A; Weckhuysen, S; Weeke, LC, 2017) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very serious forms of drug-induced cutaneous adverse reaction." | 1.43 | HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs. ( Kim, DH; Kim, J; Kim, YJ; Lee, JH; Park, HJ; Park, JW; Park, KH, 2016) |
| " Genetic analysis of DHS patients has revealed a striking association between carbamazepine (CBZ)-induced severe bullous reactions, such as Steven-Johnson Syndrome, and toxic epidermal necrolysis in individuals from Southeast Asia who carry a specific HLA allele (HLA-B*1502)." | 1.37 | Severe bullous hypersensitivity reactions after exposure to carbamazepine in a Han-Chinese child with a positive HLA-B*1502 and negative in vitro toxicity assays: evidence for different pathophysiological mechanisms. ( Bend, JR; Elzagallaai, AA; Finkelstein, Y; Garcia-Bournissen, F; Koren, G; Rieder, MJ, 2011) |
| " On the other hand, we found a gene dosage effect for mouse Sp4 gene in the modulation of sensorimotor gating, a putative endophenotype for both schizophrenia and bipolar disorder." | 1.35 | Transcription factor SP4 is a susceptibility gene for bipolar disorder. ( Geyer, MA; Greenwood, TA; Guo, S; He, L; Kelsoe, JR; Tang, W; Zhou, X, 2009) |
| "The HLA-DRB and -DRQ genetic predisposition to SJS seemed to be distinct from that of TEN, but further work is needed for both conditions to identify the causal variants." | 1.34 | Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. ( Arbuckle, JB; Bowman, CE; Brunner, M; Burns, DK; Delrieu, O; Dix, LP; Pirmohamed, M; Stern, RS; Twomey, JA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.25) | 18.2507 |
| 2000's | 12 (13.48) | 29.6817 |
| 2010's | 63 (70.79) | 24.3611 |
| 2020's | 12 (13.48) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, CSM | 1 |
| Yap, DYH | 1 |
| Ip, P | 1 |
| Wong, WHS | 1 |
| Chua, GT | 1 |
| Yeung, CK | 1 |
| Chan, HHL | 1 |
| Kwok, JSY | 1 |
| Fan, YX | 1 |
| Zhang, Z | 1 |
| Meng, JR | 1 |
| Yin, SJ | 1 |
| Wang, P | 1 |
| Zhou, T | 1 |
| Huang, YH | 1 |
| Meng, R | 1 |
| He, GH | 1 |
| Mullan, KA | 1 |
| Anderson, A | 1 |
| Shi, YW | 2 |
| Ding, JH | 1 |
| Ng, CC | 2 |
| Chen, Z | 1 |
| Baum, L | 2 |
| Cherny, S | 1 |
| Petrovski, S | 1 |
| Sham, PC | 1 |
| Lim, KS | 2 |
| Liao, WP | 2 |
| Kwan, P | 2 |
| Min, F | 1 |
| Fan, C | 1 |
| Zeng, Y | 1 |
| He, N | 1 |
| Zeng, T | 1 |
| Qin, B | 2 |
| Shi, Y | 1 |
| Biswas, M | 1 |
| Ershadian, M | 1 |
| Shobana, J | 1 |
| Nguyen, AH | 1 |
| Sukasem, C | 2 |
| Chomean, S | 1 |
| Nakkam, N | 1 |
| Tassaneeyakul, W | 4 |
| Attapong, J | 1 |
| Kaset, C | 1 |
| Wang, J | 3 |
| Huang, P | 1 |
| Yu, Q | 1 |
| Lu, J | 1 |
| Liu, P | 1 |
| Yang, Y | 2 |
| Feng, Z | 1 |
| Cai, J | 2 |
| Yang, G | 1 |
| Yuan, H | 1 |
| Tang, H | 1 |
| Lu, Y | 1 |
| Shen, M | 1 |
| Lim, JME | 1 |
| Chia, C | 1 |
| Ren, EC | 1 |
| Zhao, T | 1 |
| Wang, TT | 1 |
| Jia, L | 1 |
| Wang, F | 1 |
| Bahatibieke, M | 1 |
| Liu, WL | 1 |
| Ji, Y | 1 |
| Sun, L | 1 |
| Sun, Y | 1 |
| Li, HJ | 1 |
| Yu, LH | 1 |
| Yuliwulandari, R | 2 |
| Shin, JG | 1 |
| Kristin, E | 2 |
| Suyatna, FD | 2 |
| Prahasto, ID | 1 |
| Prayuni, K | 2 |
| Mahasirimongkol, S | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions: a Multicenter Clinical Study[NCT03184597] | 4,000 participants (Anticipated) | Interventional | 2017-08-01 | Recruiting | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 reviews available for carbamazepine and Genetic Predisposition
| Article | Year |
|---|---|
Association of ABCB1 polymorphisms with carbamazepine metabolism and resistance in epilepsy: A meta-analysis.
Topics: Asian People; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Epilepsy; Genetic Predis | 2021 |
Associations of HLA genetic variants with carbamazepine-induced cutaneous adverse drug reactions: An updated meta-analysis.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Genetic Predisposition to Disease; Genotype; HLA-A | 2022 |
HLA-associated adverse drug reactions - scoping review.
Topics: Alleles; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Genetic Predisposition to D | 2021 |
Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis.
Topics: Carbamazepine; Epilepsy; Epoxide Hydrolases; Epoxy Compounds; Genetic Predisposition to Disease; Hum | 2021 |
Association between the HLA-B alleles and carbamazepine-induced SJS/TEN: A meta-analysis.
Topics: Asian People; Carbamazepine; Genetic Predisposition to Disease; HLA-B Antigens; Humans; Stevens-John | 2017 |
A Drug Regimen for Progressive Familial Cholestasis Type 2.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; Benzothiepins; Biological Transport; Carba | 2018 |
Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
Topics: Adult; Anaplastic Lymphoma Kinase; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hyper | 2019 |
Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Autophagy; Carbamazepine; Disease Mode | 2014 |
HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.
Topics: Anticonvulsants; Asian People; Carbamazepine; Drug Hypersensitivity; Genetic Predisposition to Disea | 2014 |
[Future direction of pharmacogenomics: identification of genes associated with risk of adverse drug reactions using genome-wide association study].
Topics: Anticonvulsants; Carbamazepine; Dideoxynucleosides; Drug Eruptions; Genetic Predisposition to Diseas | 2014 |
HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.
Topics: Alleles; Allopurinol; Carbamazepine; Dideoxynucleosides; Drug Hypersensitivity Syndrome; Gene Expres | 2014 |
HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis.
Topics: Adolescent; Adult; Aged; Asian People; Carbamazepine; Epidermis; Female; Gene Frequency; Genetic Pre | 2014 |
Pharmacogenetics of hypersensitivity drug reactions.
Topics: Allopurinol; Anticonvulsants; Carbamazepine; Dideoxynucleosides; Drug Hypersensitivity; Enzyme Inhib | 2017 |
Genetic predisposition of life-threatening antiepileptic-induced skin reactions.
Topics: Anticonvulsants; Carbamazepine; Drug Labeling; Gene Frequency; Genetic Predisposition to Disease; HL | 2010 |
Genetic markers and danger signals in stevens-johnson syndrome and toxic epidermal necrolysis.
Topics: Allopurinol; Apoptosis; Biomarkers; Carbamazepine; Cytotoxicity, Immunologic; Genetic Predisposition | 2010 |
Using genome-wide association studies to identify genes important in serious adverse drug reactions.
Topics: Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 2012 |
T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Genetic Predisposition to Disease; HLA-B Anti | 2012 |
[Progress in genetic studies on severe cutaneous adverse reactions to anti-epileptic drugs].
Topics: Anticonvulsants; Asian People; Carbamazepine; China; Drug Eruptions; Genetic Predisposition to Disea | 2012 |
Pathobiology and genetics of neural tube defects.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Genetic Predisposition to Dis | 2003 |
Human leukocyte antigens and drug hypersensitivity.
Topics: Allopurinol; Carbamazepine; Dideoxynucleosides; Drug Eruptions; Drug Hypersensitivity; Genetic Predi | 2007 |
Case study: carbamazepine treatment of juvenile-onset bipolar disorder.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Carbamazepine; Child; Female; Genetic Predisposition | 1999 |
1 trial available for carbamazepine and Genetic Predisposition
| Article | Year |
|---|---|
Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor | 2008 |
67 other studies available for carbamazepine and Genetic Predisposition
| Article | Year |
|---|---|
HLA-B*15:11 status and carbamazepine-induced severe cutaneous adverse drug reactions in HLA-B*15:02 negative Chinese.
Topics: Anticonvulsants; Carbamazepine; China; Genetic Predisposition to Disease; HLA-B Antigens; HLA-B15 An | 2022 |
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti-seizure medications.
Topics: Anticonvulsants; Carbamazepine; DNA; Genetic Predisposition to Disease; HLA-B Antigens; HLA-B15 Anti | 2022 |
Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genetic Predisposition to Disease; | 2022 |
Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Dielectric Spectroscopy; Genetic Predisposition to | 2022 |
Epilepsy and long-term risk of arrhythmias.
Topics: Atrial Fibrillation; Carbamazepine; Epilepsy; Genetic Predisposition to Disease; Humans; Valproic Ac | 2023 |
CD39
Topics: Adenosine; Allergens; Antigens, CD; Apyrase; Carbamazepine; Case-Control Studies; Cells, Cultured; D | 2020 |
The Association Between HLA-A*03:01 and HLA-B*07:02 Alleles and Oxcarbazepine-induced Maculopapular Eruption in the Uighur Chinese Population.
Topics: Alleles; Anticonvulsants; Asian People; Carbamazepine; China; Genetic Predisposition to Disease; Gen | 2020 |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Femal | 2021 |
A novel TRPA1 variant is associated with carbamazepine-responsive cramp-fasciculation syndrome.
Topics: Anticonvulsants; Base Sequence; Carbamazepine; Codon, Nonsense; Exome Sequencing; Female; Genetic Pr | 2018 |
External quality assessment for laboratory testing of HLA-B*15:02 allele in relation to carbamazepine therapy.
Topics: Carbamazepine; Contraindications, Drug; Epilepsy; Genetic Predisposition to Disease; HLA-B15 Antigen | 2018 |
A novel multiplex polymerase chain reaction assay for detection of both HLA-A*31:01/HLA-B*15:02 alleles, which confer susceptibility to carbamazepine-induced severe cutaneous adverse reactions.
Topics: Alleles; Anticonvulsants; Base Sequence; Carbamazepine; Drug Hypersensitivity Syndrome; Gene Express | 2017 |
A Distinctive Ictal Amplitude-Integrated Electroencephalography Pattern in Newborns with Neonatal Epilepsy Associated with KCNQ2 Mutations.
Topics: Anticonvulsants; Brain; Brain Waves; Carbamazepine; DNA Mutational Analysis; Electroencephalography; | 2017 |
Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Fema | 2017 |
Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Allopurinol; Carbamazepine; China; DNA, Vir | 2018 |
Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population.
Topics: Adolescent; Adult; Aged; Alleles; Allergens; Anticonvulsants; Carbamazepine; Drug Hypersensitivity; | 2018 |
Response to Carbamazepine in KCNQ2 Related Early Infantile Epileptic Encephalopathy.
Topics: Carbamazepine; Electroencephalography; Exons; Genetic Predisposition to Disease; Humans; KCNQ2 Potas | 2019 |
HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions.
Topics: Acute Generalized Exanthematous Pustulosis; Alleles; Anticonvulsants; Carbamazepine; Epilepsy; Genet | 2019 |
HLA-B*57:01 confers genetic susceptibility to carbamazepine-induced SJS/TEN in Europeans.
Topics: Alleles; Carbamazepine; Female; Genetic Association Studies; Genetic Predisposition to Disease; HLA- | 2019 |
Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder.
Topics: Animals; Bipolar Disorder; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbamazepine; Cells, | 2019 |
Cost-effectiveness of screening for HLA-B*1502 prior to initiation of carbamazepine in epilepsy patients of Asian ancestry in the United States.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Genetic Predis | 2019 |
Development of a rapid and reliable single-tube multiplex real-time PCR method for
Topics: Alleles; Anticonvulsants; Asian People; Carbamazepine; Epilepsy; Female; Genetic Predisposition to D | 2019 |
HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Eruptions; Drug Hypersensi | 2013 |
Cost minimization of HLA-B*1502 screening before prescribing carbamazepine in Thailand.
Topics: Alleles; Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Genetic Predisposition to | 2013 |
Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor | 2013 |
Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Biomarkers; Carbamazepine; Case-Control Studies; Chin | 2013 |
Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore.
Topics: Adolescent; Alleles; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; | 2014 |
Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Child; | 2013 |
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; China; F | 2014 |
Presence of the HLA-A*3101 allele in a familial case of drug reaction with eosinophilia and systemic symptoms, secondary to carbamazepine.
Topics: Alleles; Anticonvulsants; Carbamazepine; Drug Eruptions; Eosinophilia; Genetic Predisposition to Dis | 2014 |
Carbamazepine-induced cutaneous reactions: a simple assay to identify patients carrying the HLA-A*31:01 allele.
Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Genetic Markers; Ge | 2014 |
Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Female; Genetic Association Studie | 2014 |
Association between HLA-B*15:02 allele and antiepileptic drug-induced severe cutaneous reactions in Hong Kong Chinese: a population-based study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Asian People; Carbamazepine; C | 2014 |
Research on Susceptible Genes and Immunological Pathogenesis of Cutaneous Adverse Drug Reactions in Chinese Hans.
Topics: Allopurinol; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvul | 2015 |
Genetic screening for human leukocyte antigen alleles prior to carbamazepine treatment.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Genetic Predisposition to Disease; Gen | 2015 |
Do HLA-A markers predict skin-reactions from aromatic antiepileptic drugs in a Norwegian population? A case control study.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cross Reactions; Epilepsy; Female; Gene | 2015 |
HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.
Topics: Adult; Aged; Alleles; Allopurinol; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studie | 2016 |
Analysis of catechol-O-methyltransferase gene mutation and identification of new pathogenic gene for paroxysmal kinesigenic dyskinesia.
Topics: Adolescent; Age of Onset; Anticonvulsants; Carbamazepine; Catechol O-Methyltransferase; Cell Cycle P | 2016 |
Carbamazepine induced Stevens-Johnson syndrome.
Topics: Adult; Asian People; Carbamazepine; Genetic Predisposition to Disease; HLA-B15 Antigen; Humans; Male | 2016 |
A study of HLA-B∗15:02 in a Sri Lankan population: Implications for pharmacogenomic testing.
Topics: Carbamazepine; Cohort Studies; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; H | 2016 |
Validation of a novel real-time PCR assay for detection of HLA-B*15:02 allele for prevention of carbamazepine - Induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis in individuals of Asian ancestry.
Topics: Alleles; Asian People; Carbamazepine; Genetic Predisposition to Disease; Genetic Testing; Genotype; | 2016 |
Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Carbamazepine; Child; Chi | 2017 |
A study of HLA-B*15:02 in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Blood Donors; Carbamazepine; China; Contraindications | 2017 |
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Genetic Predisposition t | 2008 |
Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient.
Topics: Anticonvulsants; Carbamazepine; Cells, Cultured; Child; Drug Hypersensitivity; Epoxide Hydrolases; F | 2009 |
Transcription factor SP4 is a susceptibility gene for bipolar disorder.
Topics: Adolescent; Adult; Animals; Antimanic Agents; Asian People; Bipolar Disorder; Carbamazepine; Case-Co | 2009 |
Prevention of severe cutaneous adverse drug reactions: the emerging value of pharmacogenetic screening.
Topics: Adult; Alleles; Allopurinol; Anticonvulsants; Asian People; Carbamazepine; China; Cyclosporine; Drug | 2010 |
Benign temporal lobe epilepsy.
Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Genetic Predisposit | 2010 |
Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population.
Topics: Adult; Aged; Anticonvulsants; Asian People; Carbamazepine; Child; Female; Genetic Markers; Genetic P | 2010 |
Predictive genotype.
Topics: Anticonvulsants; Carbamazepine; China; Drug Hypersensitivity; Ethnicity; Genetic Predisposition to D | 2010 |
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Asian People; Carbamazepine; C | 2011 |
Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2011 |
Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population.
Topics: Anticonvulsants; Asian People; Carbamazepine; Genetic Markers; Genetic Predisposition to Disease; HL | 2011 |
Severe bullous hypersensitivity reactions after exposure to carbamazepine in a Han-Chinese child with a positive HLA-B*1502 and negative in vitro toxicity assays: evidence for different pathophysiological mechanisms.
Topics: Anticonvulsants; Asian People; Blood Platelets; Carbamazepine; Case-Control Studies; Child; China; D | 2011 |
Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients.
Topics: Adult; Alleles; Anticonvulsants; Carbamazepine; China; Genetic Predisposition to Disease; Genotype; | 2011 |
HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain.
Topics: Adult; Aged; Alleles; Analgesics, Non-Narcotic; Carbamazepine; Case-Control Studies; Drug-Related Si | 2012 |
Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans.
Topics: Adult; Aged; Anticonvulsants; Asian People; Carbamazepine; Drug Eruptions; Epilepsy; Female; Gene Fr | 2011 |
Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.
Topics: Adult; Anticonvulsants; Biomarkers; Carbamazepine; Cell Separation; Cells, Cultured; Complementarity | 2011 |
Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502?
Topics: Adolescent; Adult; Alleles; Asian People; Carbamazepine; Child; China; Cohort Studies; Female; Genet | 2012 |
HLA-B*1502 screening in carbamazepine and lamotrigine candidates of Asian background.
Topics: Antimanic Agents; Asian People; Carbamazepine; Genetic Predisposition to Disease; Genetic Testing; H | 2012 |
Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Decision Making | 2012 |
A comprehensive electrographic and behavioral analysis of generalized tonic-clonic seizures of GEPR-9s.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Brain Mapping; Carbamazepine; Dise | 2005 |
[Paroxysmal kinesigenic dyskinesia (PKD) a rare motion disorder].
Topics: Adult; Carbamazepine; Chorea; Finland; Follow-Up Studies; Genetic Predisposition to Disease; Humans; | 2005 |
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Hypersensitivity; Exanthema; Genetic Pred | 2006 |
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Trans | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbamazepine; Child; Female; Genetic Predisposition to | 2007 |
Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Dru | 1997 |