carbamazepine and Facial Pain studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Facial Pain: Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the relationship between the efficacy of carbamazepine (CBZ) and the presence of the trigger zone for diagnosis of trigeminal neuralgia (TN)."	7.72	Diagnostic significance of carbamazepine and trigger zones in trigeminal neuralgia. ( Fukuda, H; Kaneyama, K; Notani, K; Saitoh, T; Sato, J; Segami, N, 2004)
" These patients were often on carbamazepine treatment before the procedure, a regimen known to cause severe side effects and increase pre-existing symptoms in patients with multiple sclerosis."	7.67	Paroxysmal facial pain in disseminated sclerosis treated by retrogasserian glycerol injection. ( Håkanson, S; Linderoth, B, 1989)
"Facial allodynia was assessed using von Frey test."	5.56	LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA. ( da Silva Torres, IL; de Oliveira, CL; de Oliveira, FF; de Souza, A; de Souza, VS; Lopes, BC; Marques, LX; Medeiros, LF, 2020)
" There was moderate evidence for amitriptyline in patients with atypical facial pain."	5.12	Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. ( Ananth, A; Do, TM; Kattar, N; McCoul, ED; Unis, GD, 2021)
"The most effective long-term treatments for tension-type mid-facial pain and facial migraine were low-dose amitriptyline and low-dose amitriptyline and triptans, respectively."	3.80	Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2014)
"A 72-year-old Caucasian woman with paroxysmal atrial fibrillation had been taking warfarin therapy for 5 years with a stable international normalized ratio (INR)."	3.73	Effect of carbamazepine initiation and discontinuation on antithrombotic control in a patient receiving warfarin: case report and review of the literature. ( O'donnell, PJ; Parrish, RH; Pazdur, DE, 2006)
"To investigate the relationship between the efficacy of carbamazepine (CBZ) and the presence of the trigger zone for diagnosis of trigeminal neuralgia (TN)."	3.72	Diagnostic significance of carbamazepine and trigger zones in trigeminal neuralgia. ( Fukuda, H; Kaneyama, K; Notani, K; Saitoh, T; Sato, J; Segami, N, 2004)
"Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions."	3.69	Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994)
" These patients were often on carbamazepine treatment before the procedure, a regimen known to cause severe side effects and increase pre-existing symptoms in patients with multiple sclerosis."	3.67	Paroxysmal facial pain in disseminated sclerosis treated by retrogasserian glycerol injection. ( Håkanson, S; Linderoth, B, 1989)
"Trigeminal neuralgia is one of the most characteristic and difficult to treat neuropathic pain conditions in patients with multiple sclerosis."	2.61	Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. ( Di Stefano, G; Maarbjerg, S; Truini, A, 2019)
"Trigeminal neuralgia is one of the most common causes of facial pain."	2.55	Accommodation to Diagnosis of Trigeminal Neuralgia ( Bašić Kes, V; Zadro Matovina, L, 2017)
"Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy."	2.42	Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004)
"Diagnostic evaluation of patients with orofacial pain should include complete head and neck, dental, and neurologic examinations combined with radiologic imaging of the head and appropriate laboratory tests."	2.40	When is facial pain trigeminal neuralgia? ( Alvi, A; Kumar, GK; Vartanian, AJ, 1998)
"Trigeminal neuralgia and atypical facial pain are common conditions of facial pain."	2.39	Trigeminal neuralgia versus atypical facial pain. A review of the literature and case report. ( Gobetti, JP; Türp, JC, 1996)
"Atypical facial pain is a loose term used to encompass a wide range of facial pain syndromes including those of dental and ear, nose and throat (ENT) aetiology."	2.38	Facial pain: trigeminal neuralgia. ( Lee, KH, 1993)
"The therapy of chronic facial pain still poses an important challenge."	2.38	[Treatment concept of facial pain]. ( Bremerich, A; Cesteleyn, L; Claeys, T; Kovacs, B, 1992)
" This article reviews the indications, dosing regimens, and potential side effects of the drugs used for the treatment of trigeminal and glossopharyngeal neuralgia, posttherapeutic neuralgia, temporal arteritis, and migraine based on the clinical pharmacology of these drugs, so that the most appropriate treatment for each patient can be chosen on a sound, rational basis."	2.38	Clinical pharmacology of drugs used to treat head and face pain. ( Fromm, GH, 1990)
"Facial allodynia was assessed using von Frey test."	1.56	LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA. ( da Silva Torres, IL; de Oliveira, CL; de Oliveira, FF; de Souza, A; de Souza, VS; Lopes, BC; Marques, LX; Medeiros, LF, 2020)
"Trigeminal neuralgia is a rare cause of episodic unilateral facial pain and often in the initial presentation dental causes need to be eliminated, as it frequently presents in the lower trigeminal divisions."	1.42	Trigeminal neuralgia: unilateral episodic facial pain. ( Zakrzewska, JM, 2015)
"Initial relief of the typical paroxysmal facial pain was marked in 127 patients (98%) within a median interval of 3 weeks after treatment."	1.37	Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system: technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. ( Chang, CS; Chernov, M; Hayashi, M; Iseki, H; Ivanov, P; Izawa, M; Muragaki, Y; Nagai, M; Okada, Y; Taira, T; Takakura, K; Tamura, M; Tamura, N; Yomo, S, 2011)
"Air-puff thresholds (mechanical allodynia), pin prick responses (mechanical hyperalgesia), and spontaneous scratching behavior were examined 3 days before surgery and at 3, 7, 10, 14, 17, 21, 24, 30, and 40 days after surgery."	1.35	Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats. ( Ahn, DK; Bae, YC; Han, SR; Ju, JS; Kim, BC; Lee, MK; Lim, EJ; Yang, GY, 2009)
"None of the patients reported any facial pain before surgery or trauma."	1.31	Facial pain following sinonasal surgery or facial trauma. ( Jones, NS; Khan, OA; Majumdar, S, 2002)
"Trigeminal neuralgia or tic douloureux is characterized by paroxysmal episodes of facial pain in the distribution of the trigeminal nerve, although patients may have a variety of symptoms that mimic odontogenic pain."	1.29	Trigeminal neuralgia mimicking odontogenic pain. A report of two cases. ( Law, AS; Lilly, JP, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (9.76)	18.7374
1990's	10 (24.39)	18.2507
2000's	15 (36.59)	29.6817
2010's	10 (24.39)	24.3611
2020's	2 (4.88)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Orofacial Pain in Multiple Sclerosis[NCT06021561]				200 participants (Anticipated)	Observational	2023-09-04	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. The Laryngoscope, 2021, Volume: 131, Issue:6 Topics: Adult; Amitriptyline; Botulinum Toxins, Type A; Carbamazepine; Facial Nerve; Facial Pain; Female; Hu	2021
Accommodation to Diagnosis of Trigeminal Neuralgia Acta clinica Croatica, 2017, Volume: 56, Issue:1 Topics: Ablation Techniques; Analgesics, Non-Narcotic; Blinking; Carbamazepine; Facial Pain; Humans; Magneti	2017
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. The journal of headache and pain, 2019, Feb-19, Volume: 20, Issue:1 Topics: Carbamazepine; Decompression, Surgical; Facial Pain; Humans; Magnetic Resonance Imaging; Multiple Sc	2019
Reversible focal splenial lesions in facial pain patients treated with antiepileptic drugs: case report and review of the literature. Cephalalgia : an international journal of headache, 2009, Volume: 29, Issue:5 Topics: Adult; Analgesics; Anticonvulsants; Carbamazepine; Corpus Callosum; Facial Pain; Female; Humans; Mag	2009
The efficacy of anticonvulsants on orofacial pain: a systematic review. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 111, Issue:5 Topics: Amines; Anticonvulsants; Burning Mouth Syndrome; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Ac	2011
Management issues of neuropathic trigeminal pain from a medical perspective. Journal of orofacial pain, 2004,Fall, Volume: 18, Issue:4 Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C	2004
Facial pain: trigeminal neuralgia. Annals of the Academy of Medicine, Singapore, 1993, Volume: 22, Issue:2 Topics: Anesthetics, Local; Carbamazepine; Catheter Ablation; Craniotomy; Diagnosis, Differential; Facial Pa	1993
Trigeminal neuralgia versus atypical facial pain. A review of the literature and case report. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1996, Volume: 81, Issue:4 Topics: Aged; Analgesics, Non-Narcotic; Carbamazepine; Diagnosis, Differential; Facial Pain; Female; Humans;	1996
When is facial pain trigeminal neuralgia? Postgraduate medicine, 1998, Volume: 104, Issue:4 Topics: Analgesics, Non-Narcotic; Carbamazepine; Diagnosis, Differential; Facial Pain; Humans; Trigeminal Ne	1998
Trigeminal neuralgia--an update. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2000, Volume: 21, Issue:4 Topics: Acupuncture Analgesia; Anticonvulsants; Baclofen; Carbamazepine; Facial Pain; GABA Agonists; Homeopa	2000
[Treatment concept of facial pain]. Acta stomatologica Belgica, 1992, Volume: 89, Issue:1 Topics: Antipsychotic Agents; Carbamazepine; Facial Neuralgia; Facial Pain; Glycerol; Humans; Nerve Block; N	1992
Clinical pharmacology of drugs used to treat head and face pain. Neurologic clinics, 1990, Volume: 8, Issue:1 Topics: Baclofen; Carbamazepine; Facial Pain; Humans; Migraine Disorders; Phenytoin; Trigeminal Neuralgia	1990
Facial pain. 'Why does my face hurt, doctor?'. Postgraduate medicine, 1990, Volume: 87, Issue:1 Topics: Carbamazepine; Carotid Artery Diseases; Cranial Nerve Diseases; Diagnosis, Differential; Facial Pain	1990
[Facial pain]. Revue medicale de Liege, 1986, May-01, Volume: 41, Issue:9 Topics: Acyclovir; Adrenal Cortex Hormones; Adult; Baclofen; Calcium Channel Blockers; Carbamazepine; Cervic	1986

Article	Year
LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA. Neuroscience letters, 2020, 09-25, Volume: 736 Topics: Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Factor; Carbamazepine; Disease Models,	2020
[From facial pain to toxic epidermal necrolysis: a rare complication of carbamazepine usage]. Nederlands tijdschrift voor geneeskunde, 2017, Volume: 161 Topics: Anticonvulsants; Carbamazepine; Facial Pain; Female; Humans; Indonesia; Middle Aged; Netherlands; St	2017
Topical medications for the effective management of neuropathic orofacial pain. Journal of the American Dental Association (1939), 2013, Volume: 144, Issue:6 Topics: Administration, Topical; Amines; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Age	2013
Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain. The Journal of laryngology and otology, 2014, Volume: 128, Issue:6 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Pain; Facial Pain	2014
Trigeminal neuralgia: unilateral episodic facial pain. Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:2 Topics: Analgesics, Non-Narcotic; Carbamazepine; Facial Pain; Female; Humans; Magnetic Resonance Imaging; Mi	2015
Post-traumatic short-lasting unilateral headache with cranial autonomic symptoms (SUNA). Cephalalgia : an international journal of headache, 2008, Volume: 28, Issue:9 Topics: Accidents, Traffic; Adult; Amines; Carbamazepine; Conjunctiva; Cyclohexanecarboxylic Acids; Facial P	2008
Bilateral trigeminal neuralgia and charcot-marie-tooth disease: diagnosis and successful microsurgical treatment of bilateral neurovascular compression. Zentralblatt fur Neurochirurgie, 2008, Volume: 69, Issue:3 Topics: Adult; Analgesics, Non-Narcotic; Atrophy; Carbamazepine; Cerebral Revascularization; Charcot-Marie-T	2008
Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats. European journal of pain (London, England), 2009, Volume: 13, Issue:6 Topics: Agar; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Body Weight; Carbamazepine; Facial Pain;	2009
Pharmacological treatment of a patient with first-bite syndrome. Anaesthesia, 2009, Volume: 64, Issue:1 Topics: Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cranial Nerve Neoplasms; Drug Therapy, Combi	2009
[Clinical and therapeutic aspects of trigeminal neuralgia. Apropos of 27 cases treated at the General Hospital of Grand-Yoffin Dakar]. Odonto-stomatologie tropicale = Tropical dental journal, 2009, Volume: 32, Issue:126 Topics: Adult; Age Factors; Aged; Carbamazepine; Ethanol; Facial Nerve; Facial Pain; Female; Humans; Injecti	2009
Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2010, Volume: 109, Issue:3 Topics: Aged; Botulinum Toxins, Type A; Carbamazepine; Facial Pain; Female; Humans; Myofascial Pain Syndrome	2010
Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system: technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. Neurosurgical review, 2011, Volume: 34, Issue:4 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Carbamazepine; Cohort Studies	2011
Diagnostic significance of carbamazepine and trigger zones in trigeminal neuralgia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2004, Volume: 97, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Carbamazepine; Chi-Square Dist	2004
Clinical criteria for trigeminal neuralgia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2004, Volume: 97, Issue:5 Topics: Analgesics, Non-Narcotic; Carbamazepine; Diagnosis, Differential; Facial Pain; Headache; Humans; Tri	2004
Diagnostic challenges of neuropathic tooth pain. Journal (Canadian Dental Association), 2004, Volume: 70, Issue:8 Topics: Analgesics, Non-Narcotic; Carbamazepine; Diagnosis, Differential; Facial Pain; Female; Humans; Middl	2004
Pretrigeminal neuralgia. Headache, 2005, Volume: 45, Issue:3 Topics: Aged; Aged, 80 and over; Carbamazepine; Diagnosis, Differential; Facial Pain; Female; Humans; Tootha	2005
Effect of carbamazepine initiation and discontinuation on antithrombotic control in a patient receiving warfarin: case report and review of the literature. Pharmacotherapy, 2006, Volume: 26, Issue:11 Topics: Aged; Analgesics, Non-Narcotic; Anticoagulants; Atrial Fibrillation; Carbamazepine; Drug Interaction	2006
Trigeminal neuralgia mimicking odontogenic pain. A report of two cases. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1995, Volume: 80, Issue:1 Topics: Aged; Analgesics, Non-Narcotic; Carbamazepine; Diagnosis, Differential; Facial Pain; Female; Humans;	1995
Diagnosis and treatment of persistent pain after trauma to the head and neck. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1994, Volume: 52, Issue:11 Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He	1994
SUNCT syndrome. Two cases in Argentina. Headache, 1998, Volume: 38, Issue:5 Topics: Aged; Analgesics, Non-Narcotic; Argentina; Carbamazepine; Drug Therapy, Combination; Facial Pain; Fe	1998
[Migraine and facial pain]. La Revue du praticien, 2001, Oct-15, Volume: 51, Issue:16 Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Carbamazepine; Child; Diagnosis, Differential; Dihydroe	2001
Facial pain following sinonasal surgery or facial trauma. Clinical otolaryngology and allied sciences, 2002, Volume: 27, Issue:3 Topics: Acetates; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexaneca	2002
Idiopathic trigeminal pain associated with gustatory stimuli. Pain, 1991, Volume: 44, Issue:2 Topics: Carbamazepine; Double-Blind Method; Facial Pain; Female; Humans; Middle Aged; Sucrose; Taste; Tongue	1991
[Follow-up of patients with atypical facial pain]. Deutsche zahnarztliche Zeitschrift, 1989, Volume: 44, Issue:12 Topics: Adolescent; Adult; Aged; Anesthetics, Local; Carbamazepine; Facial Pain; Female; Follow-Up Studies;	1989
Paroxysmal facial pain in disseminated sclerosis treated by retrogasserian glycerol injection. Acta neurologica Scandinavica, 1989, Volume: 80, Issue:4 Topics: Adult; Aged; Carbamazepine; Facial Pain; Female; Glycerol; Humans; Male; Middle Aged; Multiple Scler	1989
Intracranial tumors in patients with facial pain. Journal of neurosurgery, 1986, Volume: 64, Issue:6 Topics: Adult; Aged; Brain Neoplasms; Carbamazepine; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Squamo	1986

carbamazepine and Facial Pain

Research Excerpts

Research

Studies (41)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
de Oliveira, CL	1
Medeiros, LF	1
de Souza, VS	1
Lopes, BC	1
de Oliveira, FF	1
Marques, LX	1
da Silva Torres, IL	1
de Souza, A	1
Do, TM	1
Unis, GD	1
Kattar, N	1
Ananth, A	1
McCoul, ED	1
Bašić Kes, V	1
Zadro Matovina, L	1
Ahmadi, M	1
van Hoeven, L	1
Bokhoven, K	1
Di Stefano, G	1
Maarbjerg, S	1
Truini, A	1
Haribabu, PK	1
Eliav, E	2
Heir, GM	1
Amanat, D	1
Ebrahimi, H	1
Lavaee, F	1
Alipour, A	1
Agius, AM	1
Jones, NS	2
Muscat, R	1
Zakrzewska, JM	1
Jacob, S	1
Saha, A	1
Rajabally, Y	1
Tekkok, IH	1
Sumer, M	1
Ahn, DK	1
Lim, EJ	1
Kim, BC	1
Yang, GY	1
Lee, MK	1
Ju, JS	1
Han, SR	1
Bae, YC	1
Ruscheweyh, R	1
Marziniak, M	1
Evers, S	1
Phillips, TJ	1
Farquhar-Smith, WP	1
Dia Tine, S	1
Tamba, B	1
Gassama, BB	1
Niang, P	1
Dia, L	1
Kébé Ndèye, F	1
Badiane, S	1
Diallo, B	1
Ngeow, WC	1
Nair, R	1
Martin, WJ	1
Forouzanfar, T	1
Hayashi, M	1
Chernov, M	1
Tamura, N	1
Taira, T	1
Izawa, M	1
Yomo, S	1
Nagai, M	1
Chang, CS	1
Ivanov, P	1
Tamura, M	1
Muragaki, Y	1
Okada, Y	1
Iseki, H	1
Takakura, K	1
Sato, J	1
Saitoh, T	1
Notani, K	1
Fukuda, H	1
Kaneyama, K	1
Segami, N	1
Scrivani, SJ	1
Mehta, N	1
Mathews, ES	1
Maciewicz, R	1
Matwychuk, MJ	1
Watson, CP	1
Evans, RW	1
Graff-Radford, SB	1
Bassiur, JP	1
Parrish, RH	1
Pazdur, DE	1
O'donnell, PJ	1
Law, AS	1
Lilly, JP	1
Benoliel, R	2
Elishoov, H	1
Sharav, Y	2
Lee, KH	1
Türp, JC	2
Gobetti, JP	2
Raimondi, E	1
Gardella, L	1
Kumar, GK	1
Vartanian, AJ	1
Alvi, A	1
Autret, A	1
Mondon, K	1
Khan, OA	1
Majumdar, S	1
Cesteleyn, L	1
Bremerich, A	1
Claeys, T	1
Kovacs, B	1
Schnarch, A	1
Greenberg, L	1
Fromm, GH	1
Mandel, S	1
Rahn, R	1
Frenkel, G	1
Holtmann, W	1
Linderoth, B	1
Håkanson, S	1
Bullitt, E	1
Tew, JM	1
Boyd, J	1
Maertens de Noordhout, A	1
Schoenen, J	1