Page last updated: 2024-10-24

carbamazepine and Exanthema

carbamazepine has been researched along with Exanthema in 59 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Exanthema: Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)."9.14A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder. ( Aleardi, M; Biederman, J; Doyle, R; Georgiopoulos, A; Hammerness, P; Joshi, G; Kotarski, M; Mick, E; Walls, S; Williams, C; Wozniak, J, 2010)
" Carbamazepine (CBZ) is widely used in MS to control pain."7.78Comparison of carbamazepine rash in multiple sclerosis and epilepsy. ( Alvestad, S; Brodtkorb, E; Espeset, K; Hovdal, H; Lydersen, S; Shirzadi, M, 2012)
"We describe the association of the HLA-B*1502 allele in 27 epilepsy patients (19 Malays, 8 Chinese) treated with carbamazepine (CBZ) at the UKM Medical Center (UKMMC), 6 with CBZ-Steven Johnson Syndrome (CBZ-SJS), 11 with CBZ-induced rash, 2 with suspected phenytoin-induced rash and 8 negative controls."7.77Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients. ( Jamal, R; Rani, ZZ; Ratnaningrum, S; Raymond, AA; Then, SM, 2011)
" Two patients presented severe febrile skin eruption following drug intake (carbamazepine or sulfazalazine), with hypereosinophilia and hepatitis."7.71[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases]. ( Catteau, B; Delcey, V; Devulder, B; Fauchais, AL; Hachulla, E; Hatron, PY; Launay, D; Legout, L; Michon-Pasturel, U; Queyrel, V, 2001)
"Detection of DRESS syndrome is dependent on the exclusion of a variety of diseases with similar manifestations and may be delayed in time."6.44Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. ( Baldaranov, I; Gancheva, T; Ganeva, M; Hristakieva, E; Lazarova, R; Troeva, J; Tzaneva, V; Vassilev, I, 2008)
"Carbamazepine is a widely used drug."6.43Carbamazepine-induced acute liver failure as part of the DRESS syndrome. ( Holt, AP; Mutimer, DJ; Naisbitt, DJ; Pirmohamed, M; Syn, WK, 2005)
"DRESS syndrome is a multisystem disorder that appears in the context of an adverse drug reaction, characterized by fever, rash and peripheral eosinophilia with involvement of other organs such as the liver."5.91DRESS syndrome secondary to carbamazepine. ( Almohalla-Álvarez, C; Alonso-Martín, C; García-Pajares, F; González López, A; Martín Guerra, JM; Miramontes-González, JP; Morejón Huerta, B; Moreta Rodríguez, M, 2023)
"Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies."5.35Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine. ( Goh, SG; Goh, TK; Pang, SM; Thirumoorthy, T, 2008)
"DRESS syndrome is well described in adults treated with aromatic anti-epileptic drugs, such as phenytoin, phenobarbital, and carbamazepine, but also with other drugs."5.32[Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure]. ( Bosdure, E; Boyer, M; Cano, A; Reynaud, R; Roquelaure, B; Sarles, J; Viard, L, 2004)
"Generalised acute exanthematic pustuloses are severe skin reactions that are induced by drugs."5.30[Generalized acute exanthematous pustulosis caused by carbamazepine]. ( Lachgar, T, 1999)
"The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)."5.14A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder. ( Aleardi, M; Biederman, J; Doyle, R; Georgiopoulos, A; Hammerness, P; Joshi, G; Kotarski, M; Mick, E; Walls, S; Williams, C; Wozniak, J, 2010)
"Oxcarbazepine and its primary metabolite have been effective in animal models of epilepsy that generally predict efficacy in generalized tonic-clonic seizures and partial seizures in humans."4.81Oxcarbazepine, an antiepileptic agent. ( Huff, NA; Kalis, MM, 2001)
"The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone."4.80Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998)
" Carbamazepine- or oxcarbazepine-induced maculopapular exanthema occurred earlier (median: one week) than that induced by other antiseizure medications (median: three weeks) (p=0."4.02Cutaneous adverse reactions associated with antiseizure medication: clinical characteristics and implications in epilepsy treatment. ( Bettinotti, MP; Braatz, VL; de Paola, L; Iglehart, B; Lohr, A; Rodrigues, M; Silvado, CES; Tensini, FS; Tensini, TS; Von Glehn, CQC, 2021)
"Increasing studies reported genetic susceptibility to drug hypersensitivity reactions, as exemplified by the HLA-A*31:01 and HLA-B*15:02 association with carbamazepine (CBZ)-induced hypersensitivity reactions, such as maculopapular exanthema (MPE), drug rash with eosinophilia and systemic symptoms (DRESS), and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)."3.80Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations. ( Chang, PY; Chang, WC; Chang, YG; Chen, DP; Chen, MJ; Chung, WH; Ho, HC; Hsiao, YH; Hsih, MS; Hui, RC; Hung, SI; Lin, JY; Wu, T; Wu, TL; Yang, CH, 2014)
"We enrolled 19 patients with epilepsy who had discontinued oxcarbazepine because of skin rash despite an initial good response and then became refractory to other antiepileptic drugs along with an individual with paroxysmal kinesigenic dyskinesia with a similar situation."3.80Human leukocyte antigen genotypes and trial of desensitization in patients with oxcarbazepine-induced skin rash: a pilot study. ( Kang, ES; Lee, B; Lee, J; Lee, M; Yu, HJ, 2014)
" Carbamazepine (CBZ) is widely used in MS to control pain."3.78Comparison of carbamazepine rash in multiple sclerosis and epilepsy. ( Alvestad, S; Brodtkorb, E; Espeset, K; Hovdal, H; Lydersen, S; Shirzadi, M, 2012)
"We describe the association of the HLA-B*1502 allele in 27 epilepsy patients (19 Malays, 8 Chinese) treated with carbamazepine (CBZ) at the UKM Medical Center (UKMMC), 6 with CBZ-Steven Johnson Syndrome (CBZ-SJS), 11 with CBZ-induced rash, 2 with suspected phenytoin-induced rash and 8 negative controls."3.77Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients. ( Jamal, R; Rani, ZZ; Ratnaningrum, S; Raymond, AA; Then, SM, 2011)
" All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)."3.77Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011)
"Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions."3.77HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. ( Alfirevic, A; Alhusaini, S; Bourgeois, S; Carrington, M; Cavalleri, GL; Chaila, E; Chinthapalli, K; de Bakker, PI; Delanty, N; Deloukas, P; Depondt, C; Farrell, JJ; Goldstein, DB; Heinzen, EL; Jia, X; Johnson, MR; Kasperavičiūtė, D; Marson, T; McCormack, M; Molokhia, M; O'Connor, GD; Pandolfo, M; Park, BK; Pichler, W; Pirmohamed, M; Radtke, RA; Shianna, KV; Sills, GJ; Sisodiya, SM; Walley, N, 2011)
"The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)."3.73Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. ( Chang, YT; Chen, GS; Chen, WC; Chen, WH; Chen, YT; Chung, WH; Fang, WH; Hsiao, PF; Hu, SL; Huang, YL; Hung, SI; Jee, SH; Lee, WR; Lin, JJ; Lou, YH; Shih, HY; Wei, CY; Wong, TW; Wu, MT, 2006)
" Two patients presented severe febrile skin eruption following drug intake (carbamazepine or sulfazalazine), with hypereosinophilia and hepatitis."3.71[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases]. ( Catteau, B; Delcey, V; Devulder, B; Fauchais, AL; Hachulla, E; Hatron, PY; Launay, D; Legout, L; Michon-Pasturel, U; Queyrel, V, 2001)
"We report two cases of concomitant rashes and blood dyscrasias in geriatric psychiatry patients receiving carbamazepine therapy for bipolar disorder."3.70Concomitant rash and blood dyscrasias in geriatric psychiatry patients treated with carbamazepine. ( Cates, M; Powers, R, 1998)
"The first patient was a 47-year-old man who developed fever, lymphadenopathy, influenza-like symptoms, facial edema, skin rash and diarrhea after 3 weeks of carbamazepine (CBZ) treatment."3.70Colitis may be part of the antiepileptic drug hypersensitivity syndrome. ( Dofferhoff, AS; Eland, IA; Stricker, BH; Vink, R; Zondervan, PE, 1999)
"Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period."2.69An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998)
"Oxcarbazepine is a new antiepileptic drug."2.52[Adverse effects of oxcarbazepine]. ( Fang, S; Gong, ZC, 2015)
"Detection of DRESS syndrome is dependent on the exclusion of a variety of diseases with similar manifestations and may be delayed in time."2.44Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. ( Baldaranov, I; Gancheva, T; Ganeva, M; Hristakieva, E; Lazarova, R; Troeva, J; Tzaneva, V; Vassilev, I, 2008)
"Carbamazepine is a widely used drug."2.43Carbamazepine-induced acute liver failure as part of the DRESS syndrome. ( Holt, AP; Mutimer, DJ; Naisbitt, DJ; Pirmohamed, M; Syn, WK, 2005)
"DRESS syndrome is a multisystem disorder that appears in the context of an adverse drug reaction, characterized by fever, rash and peripheral eosinophilia with involvement of other organs such as the liver."1.91DRESS syndrome secondary to carbamazepine. ( Almohalla-Álvarez, C; Alonso-Martín, C; García-Pajares, F; González López, A; Martín Guerra, JM; Miramontes-González, JP; Morejón Huerta, B; Moreta Rodríguez, M, 2023)
"Lithium carbonate was associated with increased risks of rash (PT), drug interaction (PT), and tubulointerstitial diseases (SMQ)."1.72Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. ( Nabekura, T; Uwai, Y, 2022)
"Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs."1.51Hypersensitivity reactions to antiepileptic drugs in children. ( Atanasković-Marković, M; Ćirković Veličković, T; Gavrović-Jankulović, M; Janković, J; Nikolić, D; Škorić, D; Tmušić, V, 2019)
"We report a case of maculopapular skin rash due to LEV with cross-sensitivity with CBZ which has not been reported till date."1.51Cross-sensitivity of Levetiracetam and Carbamazepine Induced Skin Rash. ( Panda, S, 2019)
"Carbamazepine was and still used extensively in clinical practice in varied indications can cause adverse drug reaction shaving diverse clinical manifestations of variable severity."1.51DRESS Syndrome. ( Garg, S; Jain, P; Maheshwari, S; Sharma, VK, 2019)
"Eslicarbazepine is a new anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile."1.48Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. ( Custódio, P; Finelli, E; Leiria-Pinto, P; Porovska, O; Prates, S, 2018)
"Eslicarbazepine acetate (ESL) is an anticonvulsant drug approved for the treatment of focal epilepsies, and related to oxcarbazepine and carbamazepine (CBZ), which are also derivatives of the dibenzazepine family."1.46Eslicarbazepine acetate as a therapeutic option in a patient with carbamazepine-induced rash and HLA-A*31:01. ( Kay, L; Klein, KM; Reif, PS; Rosenow, F; Strzelczyk, A; Willems, LM; Zöllner, JP, 2017)
"DRESS syndrome is usually underdiagnosed and has a good response to systemic steroids."1.42[DRESS syndrome: Report of nine cases]. ( Barbosa-Moreno, LE; Guerrero-González, GA; Martínez-Villarreal, JD; Ocampo-Candiani, J; Ocampo-Garza, J; Ocampo-Garza, SS, 2015)
"The histopathology of DRESS syndrome highlights various associated inflammatory patterns in a single biopsy."1.42Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. ( Bastuji-Garin, S; Chosidow, O; de Feraudy, S; Delfau-Larue, MH; Duong, TA; Ortonne, N; Roujeau, JC; Valeyrie-Allanore, L; Wechsler, J; Wolkenstein, P, 2015)
"Because DRESS syndrome is potentially life threatening, it is especially important to diagnose it early."1.39Pediatrician! Do you know the symptoms of DRESS syndrome? A case report of a 4-year-old girl. ( Adamkiewicz-Drozynska, E; Irga, N; Jaworski, R; Kosiak, W; Zielinski, J, 2013)
"Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies."1.35Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine. ( Goh, SG; Goh, TK; Pang, SM; Thirumoorthy, T, 2008)
"DRESS syndrome is well described in adults treated with aromatic anti-epileptic drugs, such as phenytoin, phenobarbital, and carbamazepine, but also with other drugs."1.32[Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure]. ( Bosdure, E; Boyer, M; Cano, A; Reynaud, R; Roquelaure, B; Sarles, J; Viard, L, 2004)
"Generalised acute exanthematic pustuloses are severe skin reactions that are induced by drugs."1.30[Generalized acute exanthematous pustulosis caused by carbamazepine]. ( Lachgar, T, 1999)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.78)18.7374
1990's8 (13.56)18.2507
2000's13 (22.03)29.6817
2010's29 (49.15)24.3611
2020's5 (8.47)2.80

Authors

AuthorsStudies
Lee, JW1
Lee, SR1
Kim, MJ1
Cho, S1
Youn, SW1
Yang, MS1
Kim, SH1
Kang, HR1
Kwon, O1
Min, F1
Fan, C1
Zeng, Y1
He, N1
Zeng, T1
Qin, B1
Shi, Y1
Moreta Rodríguez, M1
García-Pajares, F1
Almohalla-Álvarez, C1
Alonso-Martín, C1
González López, A1
Miramontes-González, JP1
Martín Guerra, JM1
Morejón Huerta, B1
Uwai, Y1
Nabekura, T1
Sanoria, A1
Arora, R1
Dokania, P1
Tensini, TS1
Von Glehn, CQC1
Bettinotti, MP1
Iglehart, B1
de Paola, L1
Lohr, A1
Rodrigues, M1
Tensini, FS1
Braatz, VL1
Silvado, CES1
Kay, L1
Willems, LM1
Zöllner, JP1
Reif, PS1
Klein, KM1
Rosenow, F1
Strzelczyk, A1
Marín, JA2
Ortega, MA1
Sánchez, IP1
Pacheco, JA1
Ros, MM1
Delsing, CE1
Puerto-Fuentes, A1
Ortiz-Martínez, YS1
Finelli, E1
Custódio, P1
Porovska, O1
Prates, S1
Leiria-Pinto, P1
Salloum, S1
Lane, A1
Atanasković-Marković, M1
Janković, J1
Tmušić, V1
Gavrović-Jankulović, M1
Ćirković Veličković, T1
Nikolić, D1
Škorić, D1
Jain, P1
Garg, S1
Sharma, VK1
Maheshwari, S1
Panda, S1
Irga, N1
Kosiak, W1
Jaworski, R1
Zielinski, J1
Adamkiewicz-Drozynska, E1
Hsiao, YH1
Hui, RC1
Wu, T1
Chang, WC1
Hsih, MS1
Yang, CH2
Ho, HC2
Chang, YG1
Chen, MJ1
Lin, JY1
Chen, DP1
Chang, PY1
Wu, TL1
Hung, SI4
Chung, WH4
Toh, DS1
Tan, LL1
Aw, DC1
Pang, SM2
Lim, SH1
Thirumoorthy, T2
Lee, HY1
Tay, YK1
Tan, SK1
Vasudevan, A1
Lateef, A1
Chong, YY1
Chan, YC1
Loke, C1
Chan, CL1
Koay, ES1
Ren, EC1
Lee, EJ1
Sung, C1
Lee, B1
Yu, HJ1
Kang, ES1
Lee, M1
Lee, J1
Ortonne, N1
Valeyrie-Allanore, L1
Bastuji-Garin, S1
Wechsler, J1
de Feraudy, S1
Duong, TA1
Delfau-Larue, MH1
Chosidow, O1
Wolkenstein, P1
Roujeau, JC1
Fang, S1
Gong, ZC1
Ocampo-Garza, J1
Ocampo-Garza, SS1
Martínez-Villarreal, JD1
Barbosa-Moreno, LE1
Guerrero-González, GA1
Ocampo-Candiani, J1
Goh, TK1
Goh, SG1
Chiou, CC1
Yang, LC1
Chang, YC1
Kuo, TT1
Hu, S1
Hong, HS1
Ganeva, M1
Gancheva, T1
Lazarova, R1
Troeva, J1
Baldaranov, I1
Vassilev, I1
Hristakieva, E1
Tzaneva, V1
Joshi, G1
Wozniak, J1
Mick, E1
Doyle, R1
Hammerness, P1
Georgiopoulos, A1
Kotarski, M1
Aleardi, M1
Williams, C1
Walls, S1
Biederman, J1
Maschio, M1
Dinapoli, L1
Vidiri, A1
Muti, P1
Ben Fredj, N1
Aouam, K2
Chaabane, A2
Toumi, A1
Ben Rhomdhane, F1
Boughattas, N1
Chakroun, M1
Wang, XQ1
Lang, SY1
Shi, XB1
Tian, HJ1
Wang, RF1
Yang, F1
Pereira de Silva, N1
Piquioni, P1
Kochen, S1
Saidon, P1
McCormack, M1
Alfirevic, A1
Bourgeois, S1
Farrell, JJ1
Kasperavičiūtė, D1
Carrington, M1
Sills, GJ1
Marson, T1
Jia, X1
de Bakker, PI1
Chinthapalli, K1
Molokhia, M1
Johnson, MR1
O'Connor, GD1
Chaila, E1
Alhusaini, S1
Shianna, KV1
Radtke, RA1
Heinzen, EL1
Walley, N1
Pandolfo, M1
Pichler, W1
Park, BK1
Depondt, C1
Sisodiya, SM1
Goldstein, DB1
Deloukas, P1
Delanty, N1
Cavalleri, GL1
Pirmohamed, M2
Chauhan, A1
Anand, S1
Thomas, S1
Subramanya, HC1
Pradhan, G1
Shirzadi, M1
Alvestad, S1
Hovdal, H1
Espeset, K1
Lydersen, S1
Brodtkorb, E1
Daly, AK1
Then, SM1
Rani, ZZ1
Raymond, AA1
Ratnaningrum, S1
Jamal, R1
Yang, CY1
Dao, RL1
Lee, TJ1
Lu, CW1
Khaled, A1
Souissi, A1
Zeglaoui, F1
El Fekih, N1
Daghfous, R1
Fazaa, B1
Valencak, J1
Ortiz-Urda, S1
Heere-Ress, E1
Kunstfeld, R1
Base, W1
Marsden, D1
Libretto, SE1
Bosdure, E1
Cano, A1
Roquelaure, B1
Reynaud, R1
Boyer, M1
Viard, L1
Sarles, J1
Syn, WK1
Naisbitt, DJ1
Holt, AP1
Mutimer, DJ1
Jee, SH1
Chen, WC1
Chang, YT1
Lee, WR1
Hu, SL1
Wu, MT1
Chen, GS1
Wong, TW1
Hsiao, PF1
Chen, WH1
Shih, HY1
Fang, WH1
Wei, CY1
Lou, YH1
Huang, YL1
Lin, JJ1
Chen, YT1
Obermoser, G1
Zelger, B1
Balatsinou, C1
Milano, A1
Laterza, F1
Caldarella, MP1
Angelucci, D1
Vecchiet, J1
Zingariello, P1
Falasca, K1
Lapenna, D1
Neri, M1
Livingston, S1
Pauli, LL1
Berman, W1
Bel Hadj Ali, H1
Youssef, M1
Amri, M1
Boughattas, NA1
Zili, JE1
Alanko, K1
Madrigal Díez, V1
Alonso Palacio, J1
Arteaga Manjón-Cabeza, R1
Herranz Fernández, JL1
Cates, M1
Powers, R1
Gilliam, F1
Vazquez, B1
Sackellares, JC1
Chang, GY1
Messenheimer, J1
Nyberg, J1
Risner, ME1
Rudd, GD1
Schlienger, RG1
Shear, NH1
Lachgar, T1
Eland, IA1
Dofferhoff, AS1
Vink, R1
Zondervan, PE1
Stricker, BH1
Balasubramanian, S1
Shobhana, S1
Padmasani, LN1
Natarajan, M1
Rao, R1
Kalis, MM1
Huff, NA1
Queyrel, V1
Catteau, B1
Michon-Pasturel, U1
Fauchais, AL1
Delcey, V1
Launay, D1
Legout, L1
Hachulla, E1
Hatron, PY1
Devulder, B1
Lalla, M1
Virolainen, M1
Rasmussen, P1
Riishede, J1
Steen-Johnsen, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822]550 participants (Anticipated)Observational2022-02-18Recruiting
A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469]Phase 220 participants (Actual)Interventional2012-01-31Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for carbamazepine and Exanthema

ArticleYear
[Adverse effects of oxcarbazepine].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2015, Volume: 17, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Exanthema; Humans; Hyponatremia; Oxcarbazepine

2015
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review.
    International journal of dermatology, 2008, Volume: 47, Issue:8

    Topics: Adult; Anticonvulsants; Biopsy, Needle; Carbamazepine; Drug Eruptions; Eosinophilia; Exanthema; Fema

2008
Using genome-wide association studies to identify genes important in serious adverse drug reactions.
    Annual review of pharmacology and toxicology, 2012, Volume: 52

    Topics: Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-4

2012
Carbamazepine-induced acute liver failure as part of the DRESS syndrome.
    International journal of clinical practice, 2005, Volume: 59, Issue:8

    Topics: Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury, Chronic; Drug Eruptio

2005
Antiepileptic drug hypersensitivity syndrome.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D

1998
Oxcarbazepine, an antiepileptic agent.
    Clinical therapeutics, 2001, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions;

2001

Trials

3 trials available for carbamazepine and Exanthema

ArticleYear
A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder.
    Journal of child and adolescent psychopharmacology, 2010, Volume: 20, Issue:1

    Topics: Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Body Weight; Carb

2010
An active-control trial of lamotrigine monotherapy for partial seizures.
    Neurology, 1998, Volume: 51, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E

1998
Facial pain treated with carbamazepin (Tegretol).
    Acta neurologica Scandinavica, 1970, Volume: 46, Issue:4

    Topics: Adult; Age Factors; Aged; Carbamazepine; Clinical Trials as Topic; Dibenzazepines; Exanthema; Facial

1970

Other Studies

50 other studies available for carbamazepine and Exanthema

ArticleYear
Skin manifestations and clinical features of drug reaction with eosinophilia and systemic symptoms: a retrospective multicentre study of 125 patients.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36, Issue:9

    Topics: Carbamazepine; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Retrospective Studie

2022
Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.
    International immunopharmacology, 2022, Volume: 109

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genetic Predisposition to Disease;

2022
DRESS syndrome secondary to carbamazepine.
    Revista espanola de enfermedades digestivas, 2023, Volume: 115, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Hypersensitivity Syndrome; Eosinophilia; Exant

2023
Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database.
    Die Pharmazie, 2022, 09-01, Volume: 77, Issue:7

    Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Drug

2022
Bilateral acute angle closure as presenting feature of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS).
    Indian journal of ophthalmology, 2019, Volume: 67, Issue:10

    Topics: Acute Disease; Adult; Anterior Eye Segment; Anticonvulsants; Carbamazepine; Drug Hypersensitivity Sy

2019
Cutaneous adverse reactions associated with antiseizure medication: clinical characteristics and implications in epilepsy treatment.
    Epileptic disorders : international epilepsy journal with videotape, 2021, Jun-01, Volume: 23, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Exanthema; Humans; Oxcarbazepine; Stevens-Johnson Syndrome

2021
Eslicarbazepine acetate as a therapeutic option in a patient with carbamazepine-induced rash and HLA-A*31:01.
    Seizure, 2017, Volume: 47

    Topics: Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Epilepsy, Frontal Lobe; Exanthema; Female; Ha

2017
[Drug rash with eosinophilia and systemic symptoms syndrome induced by carbamazepine: Case report].
    Biomedica : revista del Instituto Nacional de Salud, 2017, Jun-01, Volume: 37, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Eruptions; Eosinophilia; Exanthema; Fever; Humans; Male; Syndro

2017
[A woman with fever and a rash].
    Nederlands tijdschrift voor geneeskunde, 2017, Volume: 161

    Topics: Anticonvulsants; Carbamazepine; Eosinophilia; Exanthema; Female; Fever; Humans; Liver; Middle Aged

2017
Letter to the editor "Drug rash with eosinophilia and systemic symptoms syndrome induced by carbamazepine: Case report".
    Biomedica : revista del Instituto Nacional de Salud, 2017, 09-01, Volume: 37, Issue:3

    Topics: Carbamazepine; Drug Eruptions; Eosinophilia; Exanthema; Humans

2017
Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction.
    European annals of allergy and clinical immunology, 2018, Volume: 50, Issue:5

    Topics: Allergens; Anticonvulsants; Carbamazepine; Dibenzazepines; Disease Progression; Drug Hypersensitivit

2018
Case 2: A 13-year-old Boy with a Perplexing Rash.
    Pediatrics in review, 2019, Volume: 40, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Drug Hypersensitivity Syndrome;

2019
Hypersensitivity reactions to antiepileptic drugs in children.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2019, Volume: 30, Issue:5

    Topics: Adolescent; Allergens; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Different

2019
DRESS Syndrome.
    The Journal of the Association of Physicians of India, 2019, Volume: 67, Issue:4

    Topics: Carbamazepine; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Fever; Humans

2019
Cross-sensitivity of Levetiracetam and Carbamazepine Induced Skin Rash.
    The Journal of the Association of Physicians of India, 2019, Volume: 67, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity Syndrome; Exanthema; Humans; Levetiracetam

2019
Pediatrician! Do you know the symptoms of DRESS syndrome? A case report of a 4-year-old girl.
    Pediatric emergency care, 2013, Volume: 29, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Diagnosis, Differential; Drug Hypersensitivity; Eo

2013
Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.
    Journal of dermatological science, 2014, Volume: 73, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; China; Cohort Stu

2014
Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.
    The pharmacogenomics journal, 2014, Volume: 14, Issue:4

    Topics: Adult; Alleles; Carbamazepine; Case-Control Studies; Exanthema; Genotype; HLA-B Antigens; Humans; Mi

2014
Human leukocyte antigen genotypes and trial of desensitization in patients with oxcarbazepine-induced skin rash: a pilot study.
    Pediatric neurology, 2014, Volume: 51, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Desensitization, Immunologic; D

2014
Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study.
    The British journal of dermatology, 2015, Volume: 173, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; B-Lymphocytes; Carba

2015
[DRESS syndrome: Report of nine cases].
    Revista medica de Chile, 2015, Volume: 143, Issue:5

    Topics: Adolescent; Adult; Aged; Carbamazepine; Dexamethasone; Drug Hypersensitivity Syndrome; Eosinophilia;

2015
Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine.
    Singapore medical journal, 2008, Volume: 49, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Exanthema; Female; Humans; Skin Diseases, Ves

2008
Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2008, Volume: 22, Issue:9

    Topics: Adolescent; Adult; Aged; Allopurinol; Carbamazepine; Eosinophilia; Exanthema; Female; Humans; Hydroc

2008
Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy.
    Journal of neurology, 2010, Volume: 257, Issue:11

    Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; C

2010
Hypersensitivity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol: a possible co-sensitization.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:2

    Topics: Adult; Allopurinol; Amoxicillin; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Drug Hyperse

2010
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Chi

2010
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:5

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility;

2011
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
    The New England journal of medicine, 2011, Mar-24, Volume: 364, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genome-Wide Association Study; Gen

2011
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
    The New England journal of medicine, 2011, Mar-24, Volume: 364, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genome-Wide Association Study; Gen

2011
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
    The New England journal of medicine, 2011, Mar-24, Volume: 364, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genome-Wide Association Study; Gen

2011
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
    The New England journal of medicine, 2011, Mar-24, Volume: 364, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Exanthema; Genome-Wide Association Study; Gen

2011
Carbamazepine induced DRESS syndrome.
    The Journal of the Association of Physicians of India, 2010, Volume: 58

    Topics: Adolescent; Anticonvulsants; Biopsy; Carbamazepine; Dermatitis, Exfoliative; Drug Eruptions; Drug Hy

2010
Comparison of carbamazepine rash in multiple sclerosis and epilepsy.
    Acta neurologica Scandinavica, 2012, Volume: 125, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Exanthema; Female; H

2012
Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients.
    Asian Pacific journal of allergy and immunology, 2011, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Alleles; Asian People; Carbamazepine; Child; Child, Preschool; Cohort Studies; Dr

2011
Severe cutaneous adverse reactions to antiepileptic drugs in Asians.
    Neurology, 2011, Dec-06, Volume: 77, Issue:23

    Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Exanthema; Female; Follow-Up Studies; Humans; L

2011
[DRESS syndrome].
    La Tunisie medicale, 2012, Volume: 90, Issue:10

    Topics: Adolescent; Adult; Allopurinol; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti

2012
Carbamazepine-induced DRESS syndrome with recurrent fever and exanthema.
    International journal of dermatology, 2004, Volume: 43, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Eosinophilia; Exanthema; Female; Fever; Human

2004
Hypersensitivity to topiramate sprinkle capsules does not preclude the use of topiramate tablets.
    Paediatric drugs, 2004, Volume: 6, Issue:2

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepines; Capsules; Carbamazepine; Clobaza

2004
[Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2004, Volume: 11, Issue:9

    Topics: Acute Kidney Injury; Anticonvulsants; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Exanthema;

2004
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
    Pharmacogenetics and genomics, 2006, Volume: 16, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Hypersensitivity; Exanthema; Genetic Pred

2006
Fever, eosinophilia, and a rash.
    Journal of the American Academy of Dermatology, 2006, Volume: 54, Issue:5

    Topics: Adult; Antimanic Agents; Carbamazepine; Depressive Disorder; Diagnosis, Differential; Drug Eruptions

2006
Esophagitis and anticonvulsant hypersensitivity syndrome.
    Endoscopy, 2006, Volume: 38, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Deglutition Disorders; Drug Hypersensitivity; Endoscopy, Gastrointes

2006
Carbamazepine (Tegretol) in epilepsy. Nine year follow-up study with special emphasis on untoward reactions.
    Diseases of the nervous system, 1974, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Diplopia; Drug Overd

1974
Carbamazepine-induced DRESS and HHV6 primary infection: the importance of skin tests.
    Epilepsia, 2008, Volume: 49, Issue:9

    Topics: Adult; Anticonvulsants; Carbamazepine; Eosinophilia; Epilepsy; Exanthema; Exanthema Subitum; Hematol

2008
Patch testing in cutaneous reactions caused by carbamazepine.
    Contact dermatitis, 1993, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Carbamazepine; Dermatitis, Exfoliative; Drug Eruptions; Erythema Multiforme

1993
[Carbamazepine: serious intolerance in interstitial pneumonia, fever, exanthema and immunoglobulin deficiency].
    Anales espanoles de pediatria, 1993, Volume: 38, Issue:2

    Topics: Carbamazepine; Child, Preschool; Drug Hypersensitivity; Epilepsies, Partial; Exanthema; Female; Feve

1993
Concomitant rash and blood dyscrasias in geriatric psychiatry patients treated with carbamazepine.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:9

    Topics: Aged; Antimanic Agents; Bipolar Disorder; Carbamazepine; Exanthema; Female; Humans; Male; Paraprotei

1998
[Generalized acute exanthematous pustulosis caused by carbamazepine].
    Allergie et immunologie, 1999, Volume: 31, Issue:5

    Topics: Anticonvulsants; Antimanic Agents; Carbamazepine; Drug Eruptions; Exanthema; Female; Humans; Middle

1999
Colitis may be part of the antiepileptic drug hypersensitivity syndrome.
    Epilepsia, 1999, Volume: 40, Issue:12

    Topics: Adult; Anticonvulsants; Carbamazepine; Colitis; Drug Hypersensitivity; Epilepsies, Partial; Epilepsy

1999
Carbamazepine hypersensitivity syndrome.
    Indian pediatrics, 1999, Volume: 36, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Conjunctivitis, Allergic; Drug Eruptions; Drug Hypersens

1999
[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases].
    La Revue de medecine interne, 2001, Volume: 22, Issue:6

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants

2001
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
    International archives of allergy and applied immunology, 1974, Volume: 46, Issue:2

    Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt

1974
[Severe reactions with the use of carbamazepine (Tegretol)].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Sep-01, Volume: 90, Issue:17

    Topics: Carbamazepine; Child; Dibenzazepines; Eosinophilia; Exanthema; Female; Humans; Serum Sickness; Time

1970