Page last updated: 2024-10-24

carbamazepine and Epilepsy, Complex Partial

carbamazepine has been researched along with Epilepsy, Complex Partial in 82 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)

Research Excerpts

ExcerptRelevanceReference
"Although there are very limited data in the literature, this case illustrates that a patient with a history of CPS can be treated with oxcarbazepine with no adverse effects during and after pregnancy."7.73Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006)
"A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation."7.71Carbamazepine- induced hypertension. ( Guberman, A; Jette, N; Veregin, T, 2002)
"We describe an adolescent epileptic patient who presented in nonconvulsive status epilepticus that appeared to be related to treatment with carbamazepine."7.68Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities. ( Callahan, DJ; Noetzel, MJ, 1992)
" for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC."6.67Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994)
"To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures."4.83A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. ( Chadwick, DW; Gamble, C; Marson, AG; Williamson, PR, 2006)
" Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats."3.76The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010)
"The aim of the present work was to assess serum melatonin levels and melatonin circadian rhythm in patients with diurnal and nocturnal complex partial epilepsy."3.73A comparison of the circadian rhythms and the levels of melatonin in patients with diurnal and nocturnal complex partial seizures. ( Arman, F; Erdoğan, F; Kula, M; Yalýn, O, 2006)
"Although there are very limited data in the literature, this case illustrates that a patient with a history of CPS can be treated with oxcarbazepine with no adverse effects during and after pregnancy."3.73Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006)
"A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation."3.71Carbamazepine- induced hypertension. ( Guberman, A; Jette, N; Veregin, T, 2002)
" The second patient complained of impotence after a rash while taking phenytoin and carbamazepine."3.70Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000)
"A 32-year-old man with mental retardation and uncontrolled complex partial epilepsy receiving carbamazepine (CBZ) and divalproex sodium (VPA), developed frequent episodes of forced upward gaze after increase in the daily VPA dosage."3.69Oculogyric crisis induced by carbamazepine. ( Barkley, GL; Gorman, M, 1995)
"We describe an adolescent epileptic patient who presented in nonconvulsive status epilepticus that appeared to be related to treatment with carbamazepine."3.68Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities. ( Callahan, DJ; Noetzel, MJ, 1992)
"Gabapentin appears to increase human brain GABA levels."2.68The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. ( Behar, KL; Lamoureux, D; Mattson, RH; Petroff, OA; Rothman, DL, 1996)
"Vigabatrin appears to be a reasonable choice for single-drug therapy in the treatment of certain types of seizures."2.68Newer antiepileptic drugs as monotherapy: data on vigabatrin. ( Fisher, R; Kälviäinen, R; Regesta, G; Tanganelli, P, 1996)
" Results of outcome measures, including time to exit, completion rate, and mean time on monotherapy, showed no significant differences among dosage groups."2.68Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83. ( Abou-Khalil, B; Beydoun, A; Cantrell, D; Fischer, J; Garofalo, E; Greiner, M; Harden, C; Hayes, A; Labar, DR; Pierce, M; Ramsay, RE; Sackellares, JC; Uthman, BM, 1997)
" for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC."2.67Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994)
" Fifty-two children between the age of 2 weeks and 15 years were treated with CBZ (mean dosage 17 mg/kg body weight) either as mono- (n = 36) or in polytherapy (n = 16)."2.67The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence. ( Hannak, D; Haug, C; Korinthenberg, R, 1994)
"Carbamazepine was also superior according to a composite score that combined scores for the control of seizures and for adverse effects (P less than 0."2.67A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. ( Collins, JF; Cramer, JA; Mattson, RH, 1992)
"In our case, improvement of hemiparesis and confusion occurred after about 2 weeks."1.43A case of complex partial seizure with reversible MRI abnormalities in the elderly. ( Enomoto, T; Hosaka, T; Hoshino, S; Ohkoshi, N; Shiraiwa, N; Tamaoka, A, 2016)
"Oxcarbazepine has been reported to precipitate myoclonic, generalised tonic-clonic, absence, and complex partial seizures, and carbamazepine to precipitate absences, myoclonic seizures and spasms."1.38Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures. ( Mikati, MA; Singh, P; Veerapandiyan, A, 2012)
" This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage."1.35Acetaminophen toxicity with concomitant use of carbamazepine. ( Ahmed, SN; Heino, A; Jickling, G, 2009)
"He also had endocardial cushion defect and first-degree A-V block, and underwent cardiac surgery at the age of 17 years."1.33[Postoperative complete atrioventricular block induced by carbamazepine in a patient with congenital heart disease]. ( Doi, H; Hattori, H; Kato, T; Kumada, T; Nakahata, T; Shiraishi, K; Yamanaka, Y, 2005)
"A 9-year-old girl with akinetic-rigid parkinsonism with tremor is described."1.33Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. ( Cantú-Martínez, L; Flores, Lde L; González, HC; Martínez, HR; Onofre-Castillo, J; Villarreal, HJ, 2006)
"To report a new form of reflex epilepsy in which the seizures are repeatedly and exclusively triggered by answering the telephone."1.32Telephone-induced seizures: a new type of reflex epilepsy. ( Alberto Tassinari, C; Bisulli, F; Cantalupo, G; de Haan, GJ; Gardella, E; Kasteleijn-Nolst Trenité, DG; Michelucci, R; Nichelli, P; Nobile, C; Tinuper, P; Zaniboni, A, 2004)
"We report the occurrence of a tic in a boy with Down's syndrome."1.31Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome. ( Boenigk, HE; Holtmann, M; Korn-Merker, E, 2000)
"Carbamazepine was the most commonly used AED in 71."1.31Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring. ( Chen, C; Guo, YC; Kwan, SY; Liu, LT; Shih, YH; Yen, DJ; Yiu, CH; Yu, HY, 2001)
"We studied six patients suffering from benign rolandic epilepsy of childhood with central temporal spikes who presented so-called 'extreme somatosensory evoked potentials (SEPs)' following peripheral somatosensory stimulation."1.30Influence of somatosensory input on paroxysmal activity in benign rolandic epilepsy with 'extreme somatosensory evoked potentials'. ( Bonato, C; Dalla Bernardina, B; Fiaschi, A; Manganotti, P; Marzi, CA; Miniussi, C; Santorum, E; Tinazzi, M; Zanette, G, 1998)
" CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7."1.29Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. ( Fazio, A; Perucca, E; Pisani, F; Spina, E; Tomson, T; Xiao, B, 1994)
" The dosage was increased when she developed generalized tonic-clonic seizures and she is currently maintained on a maximal dose of a controlled release formulation."1.29Case summary: Kate. ( Ebbing, A; Kirkham, FJ, 1994)
" With a view to better defining the drug's dose-response relationships in the presence of concomitant alternative antiepileptic drugs."1.29Plasma concentrations of vigabatrin in epileptic patients. ( López, E; Quintana, B; Rodriguez, I; Sánchez-Alcaraz, A, 1996)
"Carbamazepine was the antiepileptic drug prescribed most frequently followed by valproic acid."1.28[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's46 (56.10)18.2507
2000's28 (34.15)29.6817
2010's8 (9.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shiraiwa, N1
Hosaka, T1
Enomoto, T1
Hoshino, S1
Tamaoka, A1
Ohkoshi, N1
Poole, NA1
Macdonald, BK1
Agrawal, N1
Tiong, K1
Falhammar, H1
Crespo Pérez, L1
Moreira Vicente, V1
Cano Ruiz, A1
Gobernado Serrano, JM1
Cobo Ibañez, N1
Milicua Salamero, JM1
Fujiwara, A1
Watanabe, Y1
Takechi, K1
Ishikawa, T1
Kaida, Y1
Akagi, M1
Kamei, C1
Jickling, G1
Heino, A1
Ahmed, SN1
Miyahara, H1
Sonoda, K1
Okazaki, N1
Sekiguchi, K1
Kawano, T1
Akiyoshi, K1
Maeda, T1
Izumi, T1
Gube, M1
Ell, W1
Schiefer, J1
Kraus, T1
Kim, SE1
Park, KM1
Kim, SH1
Kwon, OY1
No, SK1
Calabrò, RS1
Ferlazzo, E1
Bramanti, P1
Specht, U2
Thorbecke, R1
Coban, I1
Veerapandiyan, A1
Singh, P1
Mikati, MA2
Jette, N1
Veregin, T1
Guberman, A1
Yang, MT1
Lee, WT1
Chu, LW1
Shen, YZ1
Varon, D1
Pritchard, PB1
Wagner, MT1
Topping, K1
Michelucci, R1
Gardella, E1
de Haan, GJ1
Bisulli, F1
Zaniboni, A1
Cantalupo, G1
Alberto Tassinari, C1
Tinuper, P1
Nobile, C1
Nichelli, P1
Kasteleijn-Nolst Trenité, DG1
Verrotti, A1
Latini, G1
Giannuzzi, R1
Cutarella, R1
Trotta, D1
Morgese, G1
Chiarelli, F1
Turazzini, M1
Manganotti, P2
Del Colle, R1
Silvestri, M1
Fiaschi, A2
Ranta, A1
Wooten, GF1
Zacks, JM1
Michelon, P1
Vettel, JM1
Ojemann, JG1
Assencio-Ferreira, VJ1
Mussi, ML1
Guirado, VM1
Veiga, JC1
Kumada, T1
Hattori, H1
Doi, H1
Shiraishi, K1
Yamanaka, Y1
Kato, T1
Nakahata, T1
Yalýn, O1
Arman, F1
Erdoğan, F1
Kula, M1
Gamble, C1
Williamson, PR1
Chadwick, DW1
Marson, AG1
Pushpal, D1
Shamshul, HN1
Eisenschenk, S1
Martínez, HR1
Cantú-Martínez, L1
González, HC1
Flores, Lde L1
Villarreal, HJ1
Onofre-Castillo, J1
Wurpts, G1
Ott, H1
Schlüter, A1
Häusler, M1
Novillo-López, ME1
Rossi, JE1
Dalmau, J1
Masjuan, J1
Enoki, H1
Ohtahara, S1
Gorman, M1
Barkley, GL1
Pisani, F3
Xiao, B2
Fazio, A3
Spina, E2
Perucca, E2
Tomson, T1
Silvestri, R1
de Domenico, P1
Mento, G1
Laganà, A1
di Perri, R2
Oteri, G1
Artesi, C1
Korinthenberg, R1
Haug, C1
Hannak, D1
Kirkham, FJ1
Ebbing, A1
Mayer, T1
Lee, JW1
Jubert, P1
Almirall, J1
Casanovas, A1
Garcia, M1
Helmstaedter, C1
Wagner, G1
Elger, CE1
de Romanis, F1
Sopranzi, N1
Hosoda, N1
Miura, H1
Takanashi, S1
Shirai, H1
Sunaoshi, W1
Abo, K1
Abo, J1
Avenoso, A1
Pollicino, AM1
Caputi, AP1
Reynolds, EH1
Heller, AJ1
Chadwick, D1
Johnson, T1
Walls, MJ1
Bowers, TC1
Dilsaver, SC1
Swann, AC1
Monfort, JC1
Sechi, G1
Casu, AR1
Rosati, G1
Spanu, A1
Deserra, F1
Nuvoli, S1
Deiana, GA1
Madeddu, G1
Scull, DA1
Trimble, MR1
Petroff, OA1
Rothman, DL1
Behar, KL1
Lamoureux, D1
Mattson, RH2
Fisher, R1
Kälviäinen, R1
Tanganelli, P2
Regesta, G2
Temin, PA1
Mukhin, KIu1
Rodríguez Moreno, E1
Acilona, V1
Boza, F1
Ortega, JE1
Carballo, M1
Palomino, A1
Arenas, C1
Sánchez-Alcaraz, A1
Quintana, B1
Rodriguez, I1
López, E1
Beydoun, A1
Fischer, J1
Labar, DR1
Harden, C1
Cantrell, D1
Uthman, BM1
Sackellares, JC1
Abou-Khalil, B1
Ramsay, RE1
Hayes, A1
Greiner, M1
Garofalo, E1
Pierce, M1
Miniussi, C1
Santorum, E1
Tinazzi, M1
Bonato, C1
Marzi, CA1
Dalla Bernardina, B1
Zanette, G1
Yu, H1
Yen, D1
Yiu, C1
Chung, W1
Lirng, J1
Su, M1
Batista, MS1
Silva, DF1
Ferraz, HB1
de Andrade, LA1
Ono, J1
Ikeda, T1
Imai, K1
Mano, T1
Matsuoka, T1
Nagai, T1
Okada, S1
Mirza, WU1
Rak, IW1
Thadani, VM1
Cereghino, JJ1
Garnett, WR1
Brown, LM1
Zhang, Y1
Belendiuk, GW1
Trinka, E1
Moroder, T1
Nagler, M1
Staffen, W1
Löscher, W1
Ladurner, G1
Szabo, CP1
Magnus, C1
López, L1
Thomson, A1
Rabinowicz, AL1
Gatzonis, S1
Laiaki, A1
Chioni, A1
Siafakas, A1
Zournas, C1
Mantouvalos, V1
Hamer, HM1
Morris, HH1
Maj, R1
Fariello, RG1
Pevarello, P1
Varasi, M1
McArthur, RA1
Salvati, P1
Romero, AS1
Delgado, RG1
Peña, MF1
Husain, AM1
Carwile, ST1
Miller, PP1
Radtke, RA1
Holtmann, M1
Korn-Merker, E1
Boenigk, HE1
Dodrill, CB1
Arnett, JL1
Deaton, R1
Lenz, GT1
Sommerville, KW1
Yen, DJ1
Chen, C1
Shih, YH1
Guo, YC1
Liu, LT1
Yu, HY1
Kwan, SY1
Yiu, CH1
Cramer, J1
Ryan, J1
Chang, J1
Sommerville, K1
Robertson, WC1
Doheny, HC1
Whittington, MA1
Jefferys, JG1
Patsalos, PN1
Li, S1
Lü, B1
Yang, X1
Cramer, JA1
Collins, JF1
Rönnberg, J1
Samuelsson, S1
Söderfeldt, B1
Gordon, MA1
Callahan, DJ1
Noetzel, MJ1
Browne, TR1
Feldman, RG1
Burdette, D1
Otis, J1
Fröscher, W1
Herrmann, R1
Niesen, M1
Bülau, P1
Penin, H1
Hildenbrand, G1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197]Phase 4104 participants (Actual)Interventional2018-08-06Completed
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418]Phase 4122 participants (Actual)Interventional2006-02-28Terminated (stopped due to Insufficient enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Change From Baseline in Adverse Event Profile (AEP) Score

Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months

InterventionUnits on a scale (Mean)
VNS Therapy-6.0
Best Medical Practice-3.2

Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score

The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-2.2
Best Medical Practice0.5

Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-1.0
Best Medical Practice-0.2

Changes in Anti-epileptic Drugs (AEDs)

Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months

InterventionNumber of AEDs Taken (Median)
VNS Therapy0
Best Medical Practice0

Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months

The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-0.8
Best Medical Practice-0.3

Mean Percent Change in Seizure Frequency

Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months

InterventionPercent Change (Mean)
VNS Therapy-19.1
Best Medical Practice-1.0

Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment

QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months

Interventionunits on a scale (Mean)
VNS Therapy5.5
Best Medical Practice1.2

Response Rate

Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months

Interventionparticipants (Number)
VNS Therapy10
Best Medical Practice7

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

Interventionunits on a scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score < 403.30.5

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

InterventionUnits on a Scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score >= 403.30.7

Reviews

5 reviews available for carbamazepine and Epilepsy, Complex Partial

ArticleYear
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
    Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:10

    Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine;

2009
Medicolegal assessment of the ability to drive a motor vehicle in persons with epilepsy.
    Deutsches Arzteblatt international, 2010, Volume: 107, Issue:13

    Topics: Accidents, Occupational; Accidents, Traffic; Anticonvulsants; Automobile Driving; Carbamazepine; Dec

2010
A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy.
    Neurology, 2006, May-09, Volume: 66, Issue:9

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Disease-Free Survival; Double-Blind Method; Epilepsies

2006
[The epilepsy of eating].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1996, Volume: 96, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Eating; Electroencephalography; Epilepsy, Complex Partia

1996
Clinical and EEG findings in complex partial status epilepticus with tiagabine.
    Seizure, 1999, Volume: 8, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination;

1999

Trials

17 trials available for carbamazepine and Epilepsy, Complex Partial

ArticleYear
Factors associated with poor control in partial complex epilepsy.
    Journal of child neurology, 2004, Volume: 19, Issue:4

    Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp

2004
Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2004, Volume: 25, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Electric Stimulation; Electromagnetic Fields; Epilepsy,

2004
Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy.
    Acta neurologica Scandinavica, 1994, Volume: 90, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Depressive Disorder; Double-Blind Method;

1994
The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence.
    Neuropediatrics, 1994, Volume: 25, Issue:4

    Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child Development; Child, Preschool;

1994
Propranolol in startle induced epileptic seizures.
    Journal of neurology, neurosurgery, and psychiatry, 1995, Volume: 58, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clob

1995
[Gamma-vinyl-GABA: first experiences in Italy. II].
    La Clinica terapeutica, 1994, Volume: 144, Issue:3

    Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug;

1994
Carbamazepine coadministration with fluoxetine or fluvoxamine.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:3

    Topics: Adult; Carbamazepine; Depression; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Pa

1993
Valproate versus carbamazepine for seizures.
    The New England journal of medicine, 1993, Jan-21, Volume: 328, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Complex Partial; Epile

1993
Cerebral and cerebellar diaschisis following carbamazepine therapy.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Blood Flow Velocity; Brain Damage, Chronic; Carbamazepine; Cerebrovascular Circul

1995
The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
    Annals of neurology, 1996, Volume: 39, Issue:1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response

1996
Newer antiepileptic drugs as monotherapy: data on vigabatrin.
    Neurology, 1996, Volume: 47, Issue:1 Suppl 1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies

1996
Vigabatrin vs. carbamazepine monotherapy in newly diagnosed focal epilepsy: a randomized response conditional cross-over study.
    Epilepsy research, 1996, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Over Studies; Epilepsy, Complex Parti

1996
Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83.
    Neurology, 1997, Volume: 49, Issue:3

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar

1997
Six-month evaluation of Carbatrol (extended-release carbamazepine) in complex partial seizures.
    Neurology, 1998, Volume: 51, Issue:6

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Epilepsy, Comp

1998
Tiagabine versus phenytoin and carbamazepine as add-on therapies: effects on abilities, adjustment, and mood.
    Epilepsy research, 2000, Volume: 42, Issue:2-3

    Topics: Adaptation, Psychological; Adult; Affect; Anticonvulsants; Carbamazepine; Cognition; Double-Blind Me

2000
The short-term impact of adjunctive tiagabine on health-related quality of life.
    Epilepsia, 2001, Volume: 42 Suppl 3

    Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Female; Healt

2001
A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.
    The New England journal of medicine, 1992, Sep-10, Volume: 327, Issue:11

    Topics: Adolescent; Adult; Aged; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Epilepsy, To

1992

Other Studies

60 other studies available for carbamazepine and Epilepsy, Complex Partial

ArticleYear
A case of complex partial seizure with reversible MRI abnormalities in the elderly.
    Rinsho shinkeigaku = Clinical neurology, 2016, 07-28, Volume: 56, Issue:7

    Topics: Aged; Anticonvulsants; Carbamazepine; Consciousness Disorders; Diagnosis, Differential; Electroencep

2016
Rapid onset of florid psychotic symptoms during video-EEG telemetry: undetected complex partial status?
    Epilepsia, 2009, Volume: 50, Issue:1

    Topics: Adult; Antipsychotic Agents; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Femal

2009
Carbamazepine and falsely positive screening tests for Cushing's syndrome.
    The New Zealand medical journal, 2009, Jan-23, Volume: 122, Issue:1288

    Topics: Adult; Anticonvulsants; Carbamazepine; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Epilepsy,

2009
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri

2010
Acetaminophen toxicity with concomitant use of carbamazepine.
    Epileptic disorders : international epilepsy journal with videotape, 2009, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anticonvulsants; Back Pain; Carbamazepine; Chemical

2009
Ictal bradycardia in an infant following surgical treatment for hemimegalencephaly.
    Pediatrics international : official journal of the Japan Pediatric Society, 2010, Volume: 52, Issue:1

    Topics: Anticonvulsants; Atrioventricular Block; Bradycardia; Carbamazepine; Electroencephalography; Epileps

2010
Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Complex

2010
Oxcarbazepine-related male infertility.
    Epilepsy & behavior : E&B, 2010, Volume: 19, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Humans; Infertility, Male; Male; Young Ad

2010
Having witnesses present.
    Deutsches Arzteblatt international, 2010, Volume: 107, Issue:43

    Topics: Accidents, Occupational; Accidents, Traffic; Anticonvulsants; Automobile Driving; Carbamazepine; Dec

2010
Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures.
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Infant; Oxcarbazepine; Sp

2012
Carbamazepine- induced hypertension.
    Neurology, 2002, Jul-23, Volume: 59, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Humans; Hypertension; Male

2002
Anti-epileptic drugs-induced de novo absence seizures.
    Brain & development, 2003, Volume: 25, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Complex

2003
Transient Kluver-Bucy syndrome following complex partial status epilepticus.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Functional

2003
Telephone-induced seizures: a new type of reflex epilepsy.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Epilepsy,

2004
Hyponatremia due to an additive effect of carbamazepine and thiazide diuretics.
    Epilepsia, 2004, Volume: 45, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Comorbidity; Diuretics; Drug Interactions; Epilepsy, Complex Partial

2004
Functional reorganization of spatial transformations after a parietal lesion.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Combined Modality Therapy; Drug Therapy, Combi

2004
[Transient lesion in the splenium of the corpus callosum in epileptic child with cerebral low grade glioma].
    Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:1

    Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Corpus Callosum; Epilepsy, Complex Partial;

2005
[Postoperative complete atrioventricular block induced by carbamazepine in a patient with congenital heart disease].
    No to hattatsu = Brain and development, 2005, Volume: 37, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Cardiac Pacing, Artificial; Electrocardiography; Endocar

2005
A comparison of the circadian rhythms and the levels of melatonin in patients with diurnal and nocturnal complex partial seizures.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Circadian Rhythm; Epilepsy, Complex Partial; Fema

2006
Tiagabine withdrawal-emergent mania.
    The Australian and New Zealand journal of psychiatry, 2006, Volume: 40, Issue:8

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Drug

2006
Treatment with oxcarbazepine during pregnancy.
    The neurologist, 2006, Volume: 12, Issue:5

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Oxcarbazepine; Pre

2006
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.
    Journal of child neurology, 2006, Volume: 21, Issue:12

    Topics: Anticonvulsants; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Benzothiazoles; Carbamazepine;

2006
[DRESS syndrome after carbamazepine].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2007, Volume: 58, Issue:11

    Topics: Anticonvulsants; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilepsy, Complex Partial; Fema

2007
Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man.
    Neurology, 2008, Feb-26, Volume: 70, Issue:9

    Topics: Animals; Anticonvulsants; Autoantibodies; Autoimmune Diseases; Carbamazepine; Cell Line; Epilepsy, C

2008
[Exacerbation of complex partial seizures by carbamazepine in a child with frontal lobe epilepsy].
    No to hattatsu = Brain and development, 1995, Volume: 27, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Frontal

1995
Oculogyric crisis induced by carbamazepine.
    Epilepsia, 1995, Volume: 36, Issue:11

    Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy, Complex Partial; Fixation, Ocular; Humans

1995
Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy.
    Epilepsy research, 1994, Volume: 19, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy, Complex Partial; Female; Humans;

1994
Epileptic seizures in subjects previously affected by disorders of arousal.
    Neurophysiologie clinique = Clinical neurophysiology, 1995, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Arousal; Carbamazepine; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Female

1995
Case summary: Kate.
    Seizure, 1994, Volume: 3 Suppl A

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Child, Preschoo

1994
Persistent dystonia associated with carbamazepine therapy: a case report.
    The New Zealand medical journal, 1994, Sep-14, Volume: 107, Issue:985

    Topics: Adult; Carbamazepine; Dystonia; Epilepsy, Complex Partial; Female; Humans

1994
Carbamazepine-induced acute renal failure.
    Nephron, 1994, Volume: 66, Issue:1

    Topics: Acute Kidney Injury; Carbamazepine; Epilepsy, Complex Partial; Humans; Kidney Tubular Necrosis, Acut

1994
Differential effects of first antiepileptic drug application on cognition in lesional and non-lesional patients with epilepsy.
    Seizure, 1993, Volume: 2, Issue:2

    Topics: Attention; Brain Damage, Chronic; Carbamazepine; Cognition Disorders; Electroencephalography; Epilep

1993
Skin rash caused by carbamazepine.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administr

1993
Valproate versus carbamazepine for seizures.
    The New England journal of medicine, 1993, Jan-21, Volume: 328, Issue:3

    Topics: Carbamazepine; Data Interpretation, Statistical; Epilepsies, Partial; Epilepsy, Complex Partial; Hum

1993
Catatonia associated with depression secondary to complex partial epilepsy.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:2

    Topics: Adult; Carbamazepine; Catatonia; Depressive Disorder; Epilepsy, Complex Partial; Female; Humans

1993
Valproate versus carbamazepine for seizures.
    The New England journal of medicine, 1993, Jan-21, Volume: 328, Issue:3

    Topics: Carbamazepine; Epilepsy, Complex Partial; Humans; Valproic Acid

1993
Mania precipitated by carbamazepine withdrawal.
    The British journal of psychiatry : the journal of mental science, 1995, Volume: 167, Issue:5

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Drug Therapy, Combination; Electroencephalo

1995
[Concurrence of short and long lasting episodes of nocturnal paroxysmal dystonia in an epileptic patient].
    Neurologia (Barcelona, Spain), 1997, Volume: 12, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Dystonia; Electroencephalography; Epilepsy, Complex Partial;

1997
Plasma concentrations of vigabatrin in epileptic patients.
    Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination;

1996
Influence of somatosensory input on paroxysmal activity in benign rolandic epilepsy with 'extreme somatosensory evoked potentials'.
    Brain : a journal of neurology, 1998, Volume: 121 ( Pt 4)

    Topics: Age of Onset; Anticonvulsants; Brain; Brain Mapping; Carbamazepine; Child; Electric Stimulation; Ele

1998
Pilomotor seizures.
    European neurology, 1998, Volume: 40, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Functiona

1998
Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia. Case report.
    Arquivos de neuro-psiquiatria, 1998, Volume: 56, Issue:2

    Topics: Anticonvulsants; Aphasia; Carbamazepine; Epilepsy, Complex Partial; Female; Glyburide; Humans; Hyper

1998
Intracranial lipoma of the quadrigeminal region associated with complex partial seizures.
    Pediatric radiology, 1998, Volume: 28, Issue:9

    Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Epilepsy, Complex Partial; Humans; Lipoma; M

1998
Complex partial seizures in an adolescent psychiatric inpatient setting.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:4

    Topics: Adolescent; Antipsychotic Agents; Carbamazepine; Epilepsy, Complex Partial; Hospitalization; Hospita

1999
Assessment of colour vision in epileptic patients exposed to single-drug therapy.
    European neurology, 1999, Volume: 41, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Color Perception; Color Vision Defects; Dip

1999
A case of fever following antiepileptic treatment.
    Seizure, 1999, Volume: 8, Issue:3

    Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epile

1999
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
    Seizure, 1999, Volume: 8, Issue:3

    Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens

1999
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba

1999
Interaction between trazodone and carbamazepine.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:12

    Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Depressive Disorder; Epile

1999
Improved sexual function in three men taking lamotrigine for epilepsy.
    Southern medical journal, 2000, Volume: 93, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial;

2000
Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome.
    Epileptic disorders : international epilepsy journal with videotape, 2000, Volume: 2, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Down Syndrome; Epilepsy, Complex Partial; Humans; Male; Tics

2000
Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring.
    Epilepsia, 2001, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial

2001
Carbamazepine toxicity after influenza vaccination.
    Pediatric neurology, 2002, Volume: 26, Issue:1

    Topics: Adolescent; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Influenza Vaccines; Time Facto

2002
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy.
    British journal of pharmacology, 2002, Volume: 135, Issue:6

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Levetiracetam; Male; Piracetam;

2002
[Relationship between the effect of carbamazepine on SCE frequencies and folic acid in epileptic patients].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1999, Volume: 24, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy, Complex Partial; Female; Folic Acid; Hu

1999
Memory effects following carbamazepine monotherapy in patients with complex partial epilepsy.
    Seizure, 1992, Volume: 1, Issue:4

    Topics: Adult; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Male; Memory, Short-Term; Mental Re

1992
Carbamazepine-associated thrombocytopenia.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:10

    Topics: Adult; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Thrombocytopenia

1992
Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities.
    Neurology, 1992, Volume: 42, Issue:11

    Topics: Carbamazepine; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Complex Partial; Female;

1992
A nineteen-year-old man with altered mental status.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:6

    Topics: Acetazolamide; Adult; Carbamazepine; Diagnosis, Differential; Drug Interactions; Electroencephalogra

1992
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
    Schweizer Archiv fur Neurologie und Psychiatrie (Zurich, Switzerland : 1985), 1991, Volume: 142, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin

1991