carbamazepine has been researched along with Epilepsy, Complex Partial in 82 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although there are very limited data in the literature, this case illustrates that a patient with a history of CPS can be treated with oxcarbazepine with no adverse effects during and after pregnancy." | 7.73 | Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006) |
| "A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation." | 7.71 | Carbamazepine- induced hypertension. ( Guberman, A; Jette, N; Veregin, T, 2002) |
| "We describe an adolescent epileptic patient who presented in nonconvulsive status epilepticus that appeared to be related to treatment with carbamazepine." | 7.68 | Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities. ( Callahan, DJ; Noetzel, MJ, 1992) |
| " for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC." | 6.67 | Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994) |
| "To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures." | 4.83 | A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. ( Chadwick, DW; Gamble, C; Marson, AG; Williamson, PR, 2006) |
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| "The aim of the present work was to assess serum melatonin levels and melatonin circadian rhythm in patients with diurnal and nocturnal complex partial epilepsy." | 3.73 | A comparison of the circadian rhythms and the levels of melatonin in patients with diurnal and nocturnal complex partial seizures. ( Arman, F; Erdoğan, F; Kula, M; Yalýn, O, 2006) |
| "Although there are very limited data in the literature, this case illustrates that a patient with a history of CPS can be treated with oxcarbazepine with no adverse effects during and after pregnancy." | 3.73 | Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006) |
| "A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation." | 3.71 | Carbamazepine- induced hypertension. ( Guberman, A; Jette, N; Veregin, T, 2002) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "A 32-year-old man with mental retardation and uncontrolled complex partial epilepsy receiving carbamazepine (CBZ) and divalproex sodium (VPA), developed frequent episodes of forced upward gaze after increase in the daily VPA dosage." | 3.69 | Oculogyric crisis induced by carbamazepine. ( Barkley, GL; Gorman, M, 1995) |
| "We describe an adolescent epileptic patient who presented in nonconvulsive status epilepticus that appeared to be related to treatment with carbamazepine." | 3.68 | Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities. ( Callahan, DJ; Noetzel, MJ, 1992) |
| "Gabapentin appears to increase human brain GABA levels." | 2.68 | The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. ( Behar, KL; Lamoureux, D; Mattson, RH; Petroff, OA; Rothman, DL, 1996) |
| "Vigabatrin appears to be a reasonable choice for single-drug therapy in the treatment of certain types of seizures." | 2.68 | Newer antiepileptic drugs as monotherapy: data on vigabatrin. ( Fisher, R; Kälviäinen, R; Regesta, G; Tanganelli, P, 1996) |
| " Results of outcome measures, including time to exit, completion rate, and mean time on monotherapy, showed no significant differences among dosage groups." | 2.68 | Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83. ( Abou-Khalil, B; Beydoun, A; Cantrell, D; Fischer, J; Garofalo, E; Greiner, M; Harden, C; Hayes, A; Labar, DR; Pierce, M; Ramsay, RE; Sackellares, JC; Uthman, BM, 1997) |
| " for 10 days) on the steady-state plasma concentrations of Oxcarbazepine (OXC), its active metabolite 10, 11-dihydro-10-hydroxy-carbazepine (MHD) and the corresponding diol (DHD) were studied in a randomized, double-blind cross-over placebo-controlled trial in 6 epileptic patients stabilized on a fixed dosage of OXC." | 2.67 | Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. ( Artesi, C; Di Perri, R; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Xiao, B, 1994) |
| " Fifty-two children between the age of 2 weeks and 15 years were treated with CBZ (mean dosage 17 mg/kg body weight) either as mono- (n = 36) or in polytherapy (n = 16)." | 2.67 | The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence. ( Hannak, D; Haug, C; Korinthenberg, R, 1994) |
| "Carbamazepine was also superior according to a composite score that combined scores for the control of seizures and for adverse effects (P less than 0." | 2.67 | A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. ( Collins, JF; Cramer, JA; Mattson, RH, 1992) |
| "In our case, improvement of hemiparesis and confusion occurred after about 2 weeks." | 1.43 | A case of complex partial seizure with reversible MRI abnormalities in the elderly. ( Enomoto, T; Hosaka, T; Hoshino, S; Ohkoshi, N; Shiraiwa, N; Tamaoka, A, 2016) |
| "Oxcarbazepine has been reported to precipitate myoclonic, generalised tonic-clonic, absence, and complex partial seizures, and carbamazepine to precipitate absences, myoclonic seizures and spasms." | 1.38 | Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures. ( Mikati, MA; Singh, P; Veerapandiyan, A, 2012) |
| " This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage." | 1.35 | Acetaminophen toxicity with concomitant use of carbamazepine. ( Ahmed, SN; Heino, A; Jickling, G, 2009) |
| "He also had endocardial cushion defect and first-degree A-V block, and underwent cardiac surgery at the age of 17 years." | 1.33 | [Postoperative complete atrioventricular block induced by carbamazepine in a patient with congenital heart disease]. ( Doi, H; Hattori, H; Kato, T; Kumada, T; Nakahata, T; Shiraishi, K; Yamanaka, Y, 2005) |
| "A 9-year-old girl with akinetic-rigid parkinsonism with tremor is described." | 1.33 | Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. ( Cantú-Martínez, L; Flores, Lde L; González, HC; Martínez, HR; Onofre-Castillo, J; Villarreal, HJ, 2006) |
| "To report a new form of reflex epilepsy in which the seizures are repeatedly and exclusively triggered by answering the telephone." | 1.32 | Telephone-induced seizures: a new type of reflex epilepsy. ( Alberto Tassinari, C; Bisulli, F; Cantalupo, G; de Haan, GJ; Gardella, E; Kasteleijn-Nolst Trenité, DG; Michelucci, R; Nichelli, P; Nobile, C; Tinuper, P; Zaniboni, A, 2004) |
| "We report the occurrence of a tic in a boy with Down's syndrome." | 1.31 | Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome. ( Boenigk, HE; Holtmann, M; Korn-Merker, E, 2000) |
| "Carbamazepine was the most commonly used AED in 71." | 1.31 | Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring. ( Chen, C; Guo, YC; Kwan, SY; Liu, LT; Shih, YH; Yen, DJ; Yiu, CH; Yu, HY, 2001) |
| "We studied six patients suffering from benign rolandic epilepsy of childhood with central temporal spikes who presented so-called 'extreme somatosensory evoked potentials (SEPs)' following peripheral somatosensory stimulation." | 1.30 | Influence of somatosensory input on paroxysmal activity in benign rolandic epilepsy with 'extreme somatosensory evoked potentials'. ( Bonato, C; Dalla Bernardina, B; Fiaschi, A; Manganotti, P; Marzi, CA; Miniussi, C; Santorum, E; Tinazzi, M; Zanette, G, 1998) |
| " CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7." | 1.29 | Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. ( Fazio, A; Perucca, E; Pisani, F; Spina, E; Tomson, T; Xiao, B, 1994) |
| " The dosage was increased when she developed generalized tonic-clonic seizures and she is currently maintained on a maximal dose of a controlled release formulation." | 1.29 | Case summary: Kate. ( Ebbing, A; Kirkham, FJ, 1994) |
| " With a view to better defining the drug's dose-response relationships in the presence of concomitant alternative antiepileptic drugs." | 1.29 | Plasma concentrations of vigabatrin in epileptic patients. ( López, E; Quintana, B; Rodriguez, I; Sánchez-Alcaraz, A, 1996) |
| "Carbamazepine was the antiepileptic drug prescribed most frequently followed by valproic acid." | 1.28 | [The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 46 (56.10) | 18.2507 |
| 2000's | 28 (34.15) | 29.6817 |
| 2010's | 8 (9.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shiraiwa, N | 1 |
| Hosaka, T | 1 |
| Enomoto, T | 1 |
| Hoshino, S | 1 |
| Tamaoka, A | 1 |
| Ohkoshi, N | 1 |
| Poole, NA | 1 |
| Macdonald, BK | 1 |
| Agrawal, N | 1 |
| Tiong, K | 1 |
| Falhammar, H | 1 |
| Crespo Pérez, L | 1 |
| Moreira Vicente, V | 1 |
| Cano Ruiz, A | 1 |
| Gobernado Serrano, JM | 1 |
| Cobo Ibañez, N | 1 |
| Milicua Salamero, JM | 1 |
| Fujiwara, A | 1 |
| Watanabe, Y | 1 |
| Takechi, K | 1 |
| Ishikawa, T | 1 |
| Kaida, Y | 1 |
| Akagi, M | 1 |
| Kamei, C | 1 |
| Jickling, G | 1 |
| Heino, A | 1 |
| Ahmed, SN | 1 |
| Miyahara, H | 1 |
| Sonoda, K | 1 |
| Okazaki, N | 1 |
| Sekiguchi, K | 1 |
| Kawano, T | 1 |
| Akiyoshi, K | 1 |
| Maeda, T | 1 |
| Izumi, T | 1 |
| Gube, M | 1 |
| Ell, W | 1 |
| Schiefer, J | 1 |
| Kraus, T | 1 |
| Kim, SE | 1 |
| Park, KM | 1 |
| Kim, SH | 1 |
| Kwon, OY | 1 |
| No, SK | 1 |
| Calabrò, RS | 1 |
| Ferlazzo, E | 1 |
| Bramanti, P | 1 |
| Specht, U | 2 |
| Thorbecke, R | 1 |
| Coban, I | 1 |
| Veerapandiyan, A | 1 |
| Singh, P | 1 |
| Mikati, MA | 2 |
| Jette, N | 1 |
| Veregin, T | 1 |
| Guberman, A | 1 |
| Yang, MT | 1 |
| Lee, WT | 1 |
| Chu, LW | 1 |
| Shen, YZ | 1 |
| Varon, D | 1 |
| Pritchard, PB | 1 |
| Wagner, MT | 1 |
| Topping, K | 1 |
| Michelucci, R | 1 |
| Gardella, E | 1 |
| de Haan, GJ | 1 |
| Bisulli, F | 1 |
| Zaniboni, A | 1 |
| Cantalupo, G | 1 |
| Alberto Tassinari, C | 1 |
| Tinuper, P | 1 |
| Nobile, C | 1 |
| Nichelli, P | 1 |
| Kasteleijn-Nolst Trenité, DG | 1 |
| Verrotti, A | 1 |
| Latini, G | 1 |
| Giannuzzi, R | 1 |
| Cutarella, R | 1 |
| Trotta, D | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Turazzini, M | 1 |
| Manganotti, P | 2 |
| Del Colle, R | 1 |
| Silvestri, M | 1 |
| Fiaschi, A | 2 |
| Ranta, A | 1 |
| Wooten, GF | 1 |
| Zacks, JM | 1 |
| Michelon, P | 1 |
| Vettel, JM | 1 |
| Ojemann, JG | 1 |
| Assencio-Ferreira, VJ | 1 |
| Mussi, ML | 1 |
| Guirado, VM | 1 |
| Veiga, JC | 1 |
| Kumada, T | 1 |
| Hattori, H | 1 |
| Doi, H | 1 |
| Shiraishi, K | 1 |
| Yamanaka, Y | 1 |
| Kato, T | 1 |
| Nakahata, T | 1 |
| Yalýn, O | 1 |
| Arman, F | 1 |
| Erdoğan, F | 1 |
| Kula, M | 1 |
| Gamble, C | 1 |
| Williamson, PR | 1 |
| Chadwick, DW | 1 |
| Marson, AG | 1 |
| Pushpal, D | 1 |
| Shamshul, HN | 1 |
| Eisenschenk, S | 1 |
| Martínez, HR | 1 |
| Cantú-Martínez, L | 1 |
| González, HC | 1 |
| Flores, Lde L | 1 |
| Villarreal, HJ | 1 |
| Onofre-Castillo, J | 1 |
| Wurpts, G | 1 |
| Ott, H | 1 |
| Schlüter, A | 1 |
| Häusler, M | 1 |
| Novillo-López, ME | 1 |
| Rossi, JE | 1 |
| Dalmau, J | 1 |
| Masjuan, J | 1 |
| Enoki, H | 1 |
| Ohtahara, S | 1 |
| Gorman, M | 1 |
| Barkley, GL | 1 |
| Pisani, F | 3 |
| Xiao, B | 2 |
| Fazio, A | 3 |
| Spina, E | 2 |
| Perucca, E | 2 |
| Tomson, T | 1 |
| Silvestri, R | 1 |
| de Domenico, P | 1 |
| Mento, G | 1 |
| Laganà, A | 1 |
| di Perri, R | 2 |
| Oteri, G | 1 |
| Artesi, C | 1 |
| Korinthenberg, R | 1 |
| Haug, C | 1 |
| Hannak, D | 1 |
| Kirkham, FJ | 1 |
| Ebbing, A | 1 |
| Mayer, T | 1 |
| Lee, JW | 1 |
| Jubert, P | 1 |
| Almirall, J | 1 |
| Casanovas, A | 1 |
| Garcia, M | 1 |
| Helmstaedter, C | 1 |
| Wagner, G | 1 |
| Elger, CE | 1 |
| de Romanis, F | 1 |
| Sopranzi, N | 1 |
| Hosoda, N | 1 |
| Miura, H | 1 |
| Takanashi, S | 1 |
| Shirai, H | 1 |
| Sunaoshi, W | 1 |
| Abo, K | 1 |
| Abo, J | 1 |
| Avenoso, A | 1 |
| Pollicino, AM | 1 |
| Caputi, AP | 1 |
| Reynolds, EH | 1 |
| Heller, AJ | 1 |
| Chadwick, D | 1 |
| Johnson, T | 1 |
| Walls, MJ | 1 |
| Bowers, TC | 1 |
| Dilsaver, SC | 1 |
| Swann, AC | 1 |
| Monfort, JC | 1 |
| Sechi, G | 1 |
| Casu, AR | 1 |
| Rosati, G | 1 |
| Spanu, A | 1 |
| Deserra, F | 1 |
| Nuvoli, S | 1 |
| Deiana, GA | 1 |
| Madeddu, G | 1 |
| Scull, DA | 1 |
| Trimble, MR | 1 |
| Petroff, OA | 1 |
| Rothman, DL | 1 |
| Behar, KL | 1 |
| Lamoureux, D | 1 |
| Mattson, RH | 2 |
| Fisher, R | 1 |
| Kälviäinen, R | 1 |
| Tanganelli, P | 2 |
| Regesta, G | 2 |
| Temin, PA | 1 |
| Mukhin, KIu | 1 |
| Rodríguez Moreno, E | 1 |
| Acilona, V | 1 |
| Boza, F | 1 |
| Ortega, JE | 1 |
| Carballo, M | 1 |
| Palomino, A | 1 |
| Arenas, C | 1 |
| Sánchez-Alcaraz, A | 1 |
| Quintana, B | 1 |
| Rodriguez, I | 1 |
| López, E | 1 |
| Beydoun, A | 1 |
| Fischer, J | 1 |
| Labar, DR | 1 |
| Harden, C | 1 |
| Cantrell, D | 1 |
| Uthman, BM | 1 |
| Sackellares, JC | 1 |
| Abou-Khalil, B | 1 |
| Ramsay, RE | 1 |
| Hayes, A | 1 |
| Greiner, M | 1 |
| Garofalo, E | 1 |
| Pierce, M | 1 |
| Miniussi, C | 1 |
| Santorum, E | 1 |
| Tinazzi, M | 1 |
| Bonato, C | 1 |
| Marzi, CA | 1 |
| Dalla Bernardina, B | 1 |
| Zanette, G | 1 |
| Yu, H | 1 |
| Yen, D | 1 |
| Yiu, C | 1 |
| Chung, W | 1 |
| Lirng, J | 1 |
| Su, M | 1 |
| Batista, MS | 1 |
| Silva, DF | 1 |
| Ferraz, HB | 1 |
| de Andrade, LA | 1 |
| Ono, J | 1 |
| Ikeda, T | 1 |
| Imai, K | 1 |
| Mano, T | 1 |
| Matsuoka, T | 1 |
| Nagai, T | 1 |
| Okada, S | 1 |
| Mirza, WU | 1 |
| Rak, IW | 1 |
| Thadani, VM | 1 |
| Cereghino, JJ | 1 |
| Garnett, WR | 1 |
| Brown, LM | 1 |
| Zhang, Y | 1 |
| Belendiuk, GW | 1 |
| Trinka, E | 1 |
| Moroder, T | 1 |
| Nagler, M | 1 |
| Staffen, W | 1 |
| Löscher, W | 1 |
| Ladurner, G | 1 |
| Szabo, CP | 1 |
| Magnus, C | 1 |
| López, L | 1 |
| Thomson, A | 1 |
| Rabinowicz, AL | 1 |
| Gatzonis, S | 1 |
| Laiaki, A | 1 |
| Chioni, A | 1 |
| Siafakas, A | 1 |
| Zournas, C | 1 |
| Mantouvalos, V | 1 |
| Hamer, HM | 1 |
| Morris, HH | 1 |
| Maj, R | 1 |
| Fariello, RG | 1 |
| Pevarello, P | 1 |
| Varasi, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Romero, AS | 1 |
| Delgado, RG | 1 |
| Peña, MF | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| Holtmann, M | 1 |
| Korn-Merker, E | 1 |
| Boenigk, HE | 1 |
| Dodrill, CB | 1 |
| Arnett, JL | 1 |
| Deaton, R | 1 |
| Lenz, GT | 1 |
| Sommerville, KW | 1 |
| Yen, DJ | 1 |
| Chen, C | 1 |
| Shih, YH | 1 |
| Guo, YC | 1 |
| Liu, LT | 1 |
| Yu, HY | 1 |
| Kwan, SY | 1 |
| Yiu, CH | 1 |
| Cramer, J | 1 |
| Ryan, J | 1 |
| Chang, J | 1 |
| Sommerville, K | 1 |
| Robertson, WC | 1 |
| Doheny, HC | 1 |
| Whittington, MA | 1 |
| Jefferys, JG | 1 |
| Patsalos, PN | 1 |
| Li, S | 1 |
| Lü, B | 1 |
| Yang, X | 1 |
| Cramer, JA | 1 |
| Collins, JF | 1 |
| Rönnberg, J | 1 |
| Samuelsson, S | 1 |
| Söderfeldt, B | 1 |
| Gordon, MA | 1 |
| Callahan, DJ | 1 |
| Noetzel, MJ | 1 |
| Browne, TR | 1 |
| Feldman, RG | 1 |
| Burdette, D | 1 |
| Otis, J | 1 |
| Fröscher, W | 1 |
| Herrmann, R | 1 |
| Niesen, M | 1 |
| Bülau, P | 1 |
| Penin, H | 1 |
| Hildenbrand, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
5 reviews available for carbamazepine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine; | 2009 |
Medicolegal assessment of the ability to drive a motor vehicle in persons with epilepsy.
Topics: Accidents, Occupational; Accidents, Traffic; Anticonvulsants; Automobile Driving; Carbamazepine; Dec | 2010 |
A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Disease-Free Survival; Double-Blind Method; Epilepsies | 2006 |
[The epilepsy of eating].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Eating; Electroencephalography; Epilepsy, Complex Partia | 1996 |
Clinical and EEG findings in complex partial status epilepticus with tiagabine.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1999 |
17 trials available for carbamazepine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Factors associated with poor control in partial complex epilepsy.
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp | 2004 |
Serum levels of carbamazepine and cortical excitability by magnetic brain stimulation.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Electric Stimulation; Electromagnetic Fields; Epilepsy, | 2004 |
Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Over Studies; Depressive Disorder; Double-Blind Method; | 1994 |
The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child Development; Child, Preschool; | 1994 |
Propranolol in startle induced epileptic seizures.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clob | 1995 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; | 1994 |
Carbamazepine coadministration with fluoxetine or fluvoxamine.
Topics: Adult; Carbamazepine; Depression; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Pa | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Complex Partial; Epile | 1993 |
Cerebral and cerebellar diaschisis following carbamazepine therapy.
Topics: Adolescent; Adult; Blood Flow Velocity; Brain Damage, Chronic; Carbamazepine; Cerebrovascular Circul | 1995 |
The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response | 1996 |
Newer antiepileptic drugs as monotherapy: data on vigabatrin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies | 1996 |
Vigabatrin vs. carbamazepine monotherapy in newly diagnosed focal epilepsy: a randomized response conditional cross-over study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Over Studies; Epilepsy, Complex Parti | 1996 |
Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar | 1997 |
Six-month evaluation of Carbatrol (extended-release carbamazepine) in complex partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Epilepsy, Comp | 1998 |
Tiagabine versus phenytoin and carbamazepine as add-on therapies: effects on abilities, adjustment, and mood.
Topics: Adaptation, Psychological; Adult; Affect; Anticonvulsants; Carbamazepine; Cognition; Double-Blind Me | 2000 |
The short-term impact of adjunctive tiagabine on health-related quality of life.
Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Female; Healt | 2001 |
A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.
Topics: Adolescent; Adult; Aged; Carbamazepine; Double-Blind Method; Epilepsy, Complex Partial; Epilepsy, To | 1992 |
60 other studies available for carbamazepine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
A case of complex partial seizure with reversible MRI abnormalities in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Consciousness Disorders; Diagnosis, Differential; Electroencep | 2016 |
Rapid onset of florid psychotic symptoms during video-EEG telemetry: undetected complex partial status?
Topics: Adult; Antipsychotic Agents; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Femal | 2009 |
Carbamazepine and falsely positive screening tests for Cushing's syndrome.
Topics: Adult; Anticonvulsants; Carbamazepine; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Epilepsy, | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Acetaminophen toxicity with concomitant use of carbamazepine.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anticonvulsants; Back Pain; Carbamazepine; Chemical | 2009 |
Ictal bradycardia in an infant following surgical treatment for hemimegalencephaly.
Topics: Anticonvulsants; Atrioventricular Block; Bradycardia; Carbamazepine; Electroencephalography; Epileps | 2010 |
Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Complex | 2010 |
Oxcarbazepine-related male infertility.
Topics: Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Humans; Infertility, Male; Male; Young Ad | 2010 |
Having witnesses present.
Topics: Accidents, Occupational; Accidents, Traffic; Anticonvulsants; Automobile Driving; Carbamazepine; Dec | 2010 |
Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures.
Topics: Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Infant; Oxcarbazepine; Sp | 2012 |
Carbamazepine- induced hypertension.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Humans; Hypertension; Male | 2002 |
Anti-epileptic drugs-induced de novo absence seizures.
Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Complex | 2003 |
Transient Kluver-Bucy syndrome following complex partial status epilepticus.
Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Functional | 2003 |
Telephone-induced seizures: a new type of reflex epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, | 2004 |
Hyponatremia due to an additive effect of carbamazepine and thiazide diuretics.
Topics: Anticonvulsants; Carbamazepine; Comorbidity; Diuretics; Drug Interactions; Epilepsy, Complex Partial | 2004 |
Functional reorganization of spatial transformations after a parietal lesion.
Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Combined Modality Therapy; Drug Therapy, Combi | 2004 |
[Transient lesion in the splenium of the corpus callosum in epileptic child with cerebral low grade glioma].
Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Corpus Callosum; Epilepsy, Complex Partial; | 2005 |
[Postoperative complete atrioventricular block induced by carbamazepine in a patient with congenital heart disease].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Cardiac Pacing, Artificial; Electrocardiography; Endocar | 2005 |
A comparison of the circadian rhythms and the levels of melatonin in patients with diurnal and nocturnal complex partial seizures.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Circadian Rhythm; Epilepsy, Complex Partial; Fema | 2006 |
Tiagabine withdrawal-emergent mania.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Drug | 2006 |
Treatment with oxcarbazepine during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Oxcarbazepine; Pre | 2006 |
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.
Topics: Anticonvulsants; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Benzothiazoles; Carbamazepine; | 2006 |
[DRESS syndrome after carbamazepine].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilepsy, Complex Partial; Fema | 2007 |
Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man.
Topics: Animals; Anticonvulsants; Autoantibodies; Autoimmune Diseases; Carbamazepine; Cell Line; Epilepsy, C | 2008 |
[Exacerbation of complex partial seizures by carbamazepine in a child with frontal lobe epilepsy].
Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Frontal | 1995 |
Oculogyric crisis induced by carbamazepine.
Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy, Complex Partial; Fixation, Ocular; Humans | 1995 |
Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy, Complex Partial; Female; Humans; | 1994 |
Epileptic seizures in subjects previously affected by disorders of arousal.
Topics: Adolescent; Adult; Arousal; Carbamazepine; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Female | 1995 |
Case summary: Kate.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Child, Preschoo | 1994 |
Persistent dystonia associated with carbamazepine therapy: a case report.
Topics: Adult; Carbamazepine; Dystonia; Epilepsy, Complex Partial; Female; Humans | 1994 |
Carbamazepine-induced acute renal failure.
Topics: Acute Kidney Injury; Carbamazepine; Epilepsy, Complex Partial; Humans; Kidney Tubular Necrosis, Acut | 1994 |
Differential effects of first antiepileptic drug application on cognition in lesional and non-lesional patients with epilepsy.
Topics: Attention; Brain Damage, Chronic; Carbamazepine; Cognition Disorders; Electroencephalography; Epilep | 1993 |
Skin rash caused by carbamazepine.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administr | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Carbamazepine; Data Interpretation, Statistical; Epilepsies, Partial; Epilepsy, Complex Partial; Hum | 1993 |
Catatonia associated with depression secondary to complex partial epilepsy.
Topics: Adult; Carbamazepine; Catatonia; Depressive Disorder; Epilepsy, Complex Partial; Female; Humans | 1993 |
Valproate versus carbamazepine for seizures.
Topics: Carbamazepine; Epilepsy, Complex Partial; Humans; Valproic Acid | 1993 |
Mania precipitated by carbamazepine withdrawal.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Drug Therapy, Combination; Electroencephalo | 1995 |
[Concurrence of short and long lasting episodes of nocturnal paroxysmal dystonia in an epileptic patient].
Topics: Adult; Anticonvulsants; Carbamazepine; Dystonia; Electroencephalography; Epilepsy, Complex Partial; | 1997 |
Plasma concentrations of vigabatrin in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1996 |
Influence of somatosensory input on paroxysmal activity in benign rolandic epilepsy with 'extreme somatosensory evoked potentials'.
Topics: Age of Onset; Anticonvulsants; Brain; Brain Mapping; Carbamazepine; Child; Electric Stimulation; Ele | 1998 |
Pilomotor seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Functiona | 1998 |
Complex partial seizures and aphasia as initial manifestations of non-ketotic hyperglycemia. Case report.
Topics: Anticonvulsants; Aphasia; Carbamazepine; Epilepsy, Complex Partial; Female; Glyburide; Humans; Hyper | 1998 |
Intracranial lipoma of the quadrigeminal region associated with complex partial seizures.
Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Child; Epilepsy, Complex Partial; Humans; Lipoma; M | 1998 |
Complex partial seizures in an adolescent psychiatric inpatient setting.
Topics: Adolescent; Antipsychotic Agents; Carbamazepine; Epilepsy, Complex Partial; Hospitalization; Hospita | 1999 |
Assessment of colour vision in epileptic patients exposed to single-drug therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Color Perception; Color Vision Defects; Dip | 1999 |
A case of fever following antiepileptic treatment.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epile | 1999 |
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Interaction between trazodone and carbamazepine.
Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Depressive Disorder; Epile | 1999 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Down Syndrome; Epilepsy, Complex Partial; Humans; Male; Tics | 2000 |
Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Complex Partial | 2001 |
Carbamazepine toxicity after influenza vaccination.
Topics: Adolescent; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Influenza Vaccines; Time Facto | 2002 |
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Levetiracetam; Male; Piracetam; | 2002 |
[Relationship between the effect of carbamazepine on SCE frequencies and folic acid in epileptic patients].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy, Complex Partial; Female; Folic Acid; Hu | 1999 |
Memory effects following carbamazepine monotherapy in patients with complex partial epilepsy.
Topics: Adult; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Male; Memory, Short-Term; Mental Re | 1992 |
Carbamazepine-associated thrombocytopenia.
Topics: Adult; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Thrombocytopenia | 1992 |
Prolonged absence status epilepticus associated with carbamazepine therapy, increased intracranial pressure, and transient MRI abnormalities.
Topics: Carbamazepine; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Complex Partial; Female; | 1992 |
A nineteen-year-old man with altered mental status.
Topics: Acetazolamide; Adult; Carbamazepine; Diagnosis, Differential; Drug Interactions; Electroencephalogra | 1992 |
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin | 1991 |