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carbamazepine and Drug Refractory Epilepsy

carbamazepine has been researched along with Drug Refractory Epilepsy in 33 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)."9.41Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023)
" The efficacy evaluation of NPs/KCZ was evaluated in a kainic acid (KA)-induced mice model of epilepsy with carbamazepine (CBZ) treatment."8.12Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. ( Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J, 2022)
"Epigenetics underlying refractory epilepsy is poorly understood."5.51Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population. ( Cui, L; Lv, Y; Shi, M; Wang, Z; Zheng, X, 2019)
"Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)."5.41Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023)
"In adults with focal seizures, adjunctive BRV treatment does not affect plasma concentrations of the evaluated AEDs but increases carbamazepine epoxide metabolite."5.30Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials. ( Moseley, BD; Otoul, C; Staelens, L; Stockis, A, 2019)
"The gene polymorphisms of ABCB1, EPHX1, and SCN1A were found to influence carbamazepine (CBZ) metabolism and resistance in epilepsy patients, but the relevance remains controversial."5.12ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients. ( Bai, ZF; Chen, XF; Chen, XL; Li, WX; Tang, JF; Wang, XY; Xiao, XH; Zhang, H; Zhang, ML; Zhang, SQ; Zhao, X; Zhao, YL, 2021)
" The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy."4.98Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018)
"The purpose of this study was to detect the changes of P-Glycoprotein (P-GP) expression in rat brain microvessel endothelial cell line RBE4 after the action of Tetramethylpyrazine (TMP) on Carbamazepine (CBZ), so as to clarify the potential mechanism of TMP combined with CBZ against intractable epilepsy drug resistance."4.31Study on the reversal of epileptic drug resistance by tetramethylpyrazine in combination with carbamazepine through modulation of P-Glycoprotein expression in rat brain microvessel endothelial cell. ( Deng, Y; Li, Y; Liu, J; Liu, W; Qian, X; Wang, J; Xiao, G; Yan, J; Ye, J; Zhong, N, 2023)
" The efficacy evaluation of NPs/KCZ was evaluated in a kainic acid (KA)-induced mice model of epilepsy with carbamazepine (CBZ) treatment."4.12Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. ( Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J, 2022)
" There were no notable differences in overall tolerability between subgroups, but the incidence of some adverse events (eg, dizziness, somnolence, nausea) differed between subgroups and/or between treatment periods."2.87Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine. ( Blum, D; Cheng, H; Grinnell, T; Harvey, JH; Pazdera, L; Sam, MC; Sperling, MR; Strom, LA, 2018)
"Data on epilepsy syndrome, duration, seizure types, concomitant and previous antiseizure medication (ASM) use, BRV dosing, efficacy, and side effects were recorded."1.72Retention of brivaracetam in adults with drug-resistant epilepsy at a single tertiary care center. ( Green, SF; Hare, N; Kassam, M; Koepp, MJ; Rajakulendran, S; Rugg-Gunn, F; Sander, JW, 2022)
"Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action."1.51Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y; Tani, H; Tateishi, Y, 2019)
"Epigenetics underlying refractory epilepsy is poorly understood."1.51Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population. ( Cui, L; Lv, Y; Shi, M; Wang, Z; Zheng, X, 2019)
"Conclusions Depressive disorders are common, underdiagnosed and undertreated in patients with refractory MTLE."1.48Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy. ( Cendes, F; de Oliveira Cardoso, TAM; Gonçalves, EB; Yasuda, CL, 2018)
"Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE])."1.46Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy. ( Aroni, S; Marrosu, F; Melis, M; Milioli, G; Muntoni, AL; Parrino, L; Pillolla, G; Pistis, M; Puligheddu, M; Sagheddu, C; Terzano, GM, 2017)
" Patients were switched because they experienced persistent seizures with OXC but were unable to tolerate increased OXC dosing due to adverse events."1.46Overnight switching from oxcarbazepine to eslicarbazepine acetate: an observational study. ( Höfler, J; Kalss, G; Kirschner, M; Kuchukhidze, G; Leitinger, M; Rohracher, A; Schmid, E; Steinhoff, BJ; Trinka, E; Wendling, AS, 2017)
"Seven (10."1.46Drug-resistant epilepsy in children with partial onset epilepsy treated with carbamazepine. ( Aungaroon, G; Holland, KD; Horn, PS; Imming, CM; Standridge, SM, 2017)
" We sought to determine whether there were regions in the dosage range of commonly used AEDs that were associated with superior efficacy in patients with refractory epilepsy."1.46Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. ( Castagna, CE; Miller, AB; Poolos, NP; Story, TJ; Williams, S, 2017)
"Adolescents with pharmacologically intractable epilepsy had lower lexical fluency scores than healthy peers, but did not differ from them on the dimensions of lexical breadth and lexical depth."1.43Lexicon before and after epilepsy surgery in adolescents. ( Braams, OB; Braun, KP; Chanturidze, M; Hendriks, MP; Jennekens-Schinkel, A; Meekes, J; van Nieuwenhuizen, O; van Rijen, PC, 2016)
"Daytime somnolence was reported by 28 patients, 15 on OXC (10%); 8 received oral modafinil for the same, while none discontinued this AED."1.43Behavioral effects and somnolence due to levetiracetam versus oxcarbazepine - a retrospective comparison study of North Indian patients with refractory epilepsy. ( Agarwal, P; Gupta, A; Poornima, S; Shukla, G, 2016)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's23 (69.70)24.3611
2020's10 (30.30)2.80

Authors

AuthorsStudies
Green, SF1
Hare, N1
Kassam, M1
Rugg-Gunn, F1
Koepp, MJ2
Sander, JW2
Rajakulendran, S1
Wang, J2
Fu, J1
Sun, W1
Yin, X1
Lv, K1
Zhang, J1
Ziganshina, LE1
Abakumova, T1
Hoyle, CHV1
Qian, X1
Deng, Y1
Zhong, N1
Li, Y1
Yan, J1
Liu, W1
Ye, J1
Liu, J1
Xiao, G1
Zavala-Tecuapetla, C1
Orozco-Suarez, S1
Manjarrez, J1
Cuellar-Herrera, M1
Vega-Garcia, A1
Buzoianu-Anguiano, V1
Moseley, BD1
Otoul, C1
Staelens, L1
Stockis, A1
Yamamoto, A1
Saito, Y1
Oyama, Y1
Watanabe, Y1
Ikeda, A1
Takayama, R1
Ikeda, H1
Takeshita, S1
Takumi, I1
Itai, T1
Miyatake, S1
Matsumoto, N1
Koneval, Z1
Knox, KM1
Memon, A1
Zierath, DK1
White, HS1
Barker-Haliski, M1
Quon, RJ1
Meisenhelter, S1
Adamovich-Zeitlin, RH1
Song, Y1
Steimel, SA1
Camp, EJ1
Testorf, ME1
MacKenzie, TA1
Gross, RE1
Lega, BC1
Sperling, MR2
Kahana, MJ1
Jobst, BC1
Cho, SJ1
Park, E1
Baker, A1
Reid, AY1
Zhang, ML1
Chen, XL1
Bai, ZF1
Zhao, X1
Li, WX1
Wang, XY1
Zhang, H1
Chen, XF1
Zhang, SQ1
Tang, JF1
Xiao, XH1
Zhao, YL1
Puligheddu, M1
Melis, M1
Pillolla, G1
Milioli, G1
Parrino, L1
Terzano, GM1
Aroni, S1
Sagheddu, C1
Marrosu, F1
Pistis, M1
Muntoni, AL1
Shakir, S1
Ali, N1
Udin, Z1
Nazish, H1
Nabi, M1
Kheloufi, F1
Default, A1
Perrouty, B1
Blin, O1
Micallef, J1
Gonçalves, EB1
de Oliveira Cardoso, TAM1
Yasuda, CL1
Cendes, F1
Rosati, A1
Ilvento, L1
Lucenteforte, E1
Pugi, A1
Crescioli, G1
McGreevy, KS1
Virgili, G1
Mugelli, A1
De Masi, S1
Guerrini, R1
Pazdera, L1
Harvey, JH1
Sam, MC1
Strom, LA1
Blum, D1
Grinnell, T1
Cheng, H1
Zybina, A1
Anshakova, A1
Malinovskaya, J1
Melnikov, P1
Baklaushev, V1
Chekhonin, V1
Maksimenko, O1
Titov, S1
Balabanyan, V1
Kreuter, J1
Gelperina, S1
Abbasova, K1
Beckonert, NM1
Opitz, T1
Pitsch, J1
Soares da Silva, P1
Beck, H1
Xiao, F1
Caciagli, L1
Wandschneider, B1
Sidhu, M1
Winston, G1
Burdett, J1
Trimmel, K1
Hill, A1
Vollmar, C1
Vos, SB1
Ourselin, S1
Thompson, PJ1
Zhou, D1
Duncan, JS1
Huang, Q1
Yu, L1
Ma, M1
Qi, H1
Wu, Y1
Ishikawa, N1
Tateishi, Y1
Tani, H1
Kobayashi, Y1
Kobayashi, M1
Lv, Y1
Zheng, X1
Shi, M1
Wang, Z1
Cui, L1
Mateo-Carrasco, H1
Serrano-Castro, PJ1
Molina-Cuadrado, E1
Goodwin, M1
Nguyen, TV1
Kotecha, PN1
Meekes, J1
Chanturidze, M1
Braams, OB1
Braun, KP1
van Rijen, PC1
Hendriks, MP1
Jennekens-Schinkel, A1
van Nieuwenhuizen, O1
Klaft, ZJ1
Hollnagel, JO1
Salar, S1
Calişkan, G1
Schulz, SB1
Schneider, UC1
Horn, P1
Koch, A1
Holtkamp, M1
Gabriel, S1
Gerevich, Z1
Heinemann, U1
Cappaert, NL1
Werkman, TR1
Benito, N1
Witter, MP1
Baayen, JC1
Wadman, WJ1
Schmid, E1
Kuchukhidze, G1
Kirschner, M1
Leitinger, M1
Höfler, J1
Rohracher, A1
Kalss, G1
Wendling, AS1
Steinhoff, BJ1
Trinka, E1
Fallah, A1
Weil, AG1
Wang, S1
Lewis, E1
Baca, CB1
Mathern, GW1
Shukla, G1
Gupta, A1
Agarwal, P1
Poornima, S1
Aungaroon, G1
Holland, KD1
Horn, PS1
Standridge, SM1
Imming, CM1
Tarnutzer, AA1
Imbach, LL1
Poolos, NP1
Castagna, CE1
Williams, S1
Miller, AB1
Story, TJ1

Reviews

4 reviews available for carbamazepine and Drug Refractory Epilepsy

ArticleYear
Gabapentin monotherapy for epilepsy: A review.
    The International journal of risk & safety in medicine, 2023, Volume: 34, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Gabapentin;

2023
ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.
    Gene, 2021, Dec-30, Volume: 805

    Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor

2021
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
    Epilepsia, 2018, Volume: 59, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch

2018
Role of high-dose levetiracetam as add-on therapy for intractable epilepsy: case report and brief review of the literature.
    International journal of clinical pharmacy, 2015, Volume: 37, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Drug Synergism; Drug Therapy, Combin

2015

Trials

3 trials available for carbamazepine and Drug Refractory Epilepsy

ArticleYear
Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials.
    Epilepsy research, 2019, Volume: 158

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans;

2019
Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine.
    Epilepsia, 2018, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Resistant Epilepsy; Dr

2018
Effects of carbamazepine and lamotrigine on functional magnetic resonance imaging cognitive networks.
    Epilepsia, 2018, Volume: 59, Issue:7

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain; Carbamazepine; Cognition; Dose-Response Relationshi

2018

Other Studies

26 other studies available for carbamazepine and Drug Refractory Epilepsy

ArticleYear
Retention of brivaracetam in adults with drug-resistant epilepsy at a single tertiary care center.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Drug Therapy, Combination; Drug-Related Sid

2022
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
    Epilepsy research, 2022, Volume: 186

    Topics: Animals; Brain; Carbamazepine; Drug Resistant Epilepsy; Epilepsy; Kainic Acid; Ketoconazole; Mice; M

2022
Study on the reversal of epileptic drug resistance by tetramethylpyrazine in combination with carbamazepine through modulation of P-Glycoprotein expression in rat brain microvessel endothelial cell.
    Cellular and molecular biology (Noisy-le-Grand, France), 2023, Nov-15, Volume: 69, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2023
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling.
    Brain research, 2020, 01-01, Volume: 1726

    Topics: Animals; Anticonvulsants; Brain; Capillaries; Carbamazepine; Disease Models, Animal; Drug Resistant

2020
Effect of total callosotomy on KCNQ2-related intractable epilepsy.
    Brain & development, 2020, Volume: 42, Issue:8

    Topics: Carbamazepine; Child; Corpus Callosum; Drug Resistant Epilepsy; Electroencephalography; Female; Huma

2020
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea;

2020
Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy.
    Epilepsia, 2021, Volume: 62, Issue:2

    Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Drug Resistant Epilepsy; Electrocorticography; Fem

2021
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
    Journal of neurotrauma, 2021, 11-15, Volume: 38, Issue:22

    Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista

2021
Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Disease Models, Animal; D

2017
Vitamin B
    African health sciences, 2017, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistant Epilepsy;

2017
Perampanel-associated self-harm ideation after dosage increase.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsie

2018
Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy.
    The Journal of international medical research, 2018, Volume: 46, Issue:2

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Carbamazepine; Clobazam; Depressive

2018
Nanoparticle-based delivery of carbamazepine: A promising approach for the treatment of refractory epilepsy.
    International journal of pharmaceutics, 2018, Aug-25, Volume: 547, Issue:1-2

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbamazep

2018
Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 06-13, Volume: 38, Issue:24

    Topics: Animals; Anticonvulsants; Biogenic Polyamines; Carbamazepine; Drug Resistance; Drug Resistant Epilep

2018
Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report.
    Medicine, 2019, Volume: 98, Issue:8

    Topics: Adult; Anticonvulsants; Ataxia; Carbamazepine; Disease Progression; Drug Resistant Epilepsy; Electro

2019
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 94

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dizziness; Drug Resistant Epile

2019
Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population.
    BMC neurology, 2019, Jun-04, Volume: 19, Issue:1

    Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; DNA Methylation; Drug Resistance; Drug Resistan

2019
Lexicon before and after epilepsy surgery in adolescents.
    Neuropsychology, 2016, Volume: 30, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Drug Resistant Epilepsy; Fem

2016
Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices.
    Epilepsia, 2016, Volume: 57, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Adult; Bicuculline; Carbamazepine; Drug Resistant Epilepsy; Elect

2016
Carbamazepine modulates the spatiotemporal activity in the dentate gyrus of rats and pharmacoresistant humans in vitro.
    Brain and behavior, 2016, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Carbamazepine; Dentate Gyrus; Drug Resistant Epilepsy;

2016
Overnight switching from oxcarbazepine to eslicarbazepine acetate: an observational study.
    Acta neurologica Scandinavica, 2017, Volume: 135, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Resistant Epilepsy; Drug Substitut

2017
Cost-utility analysis of competing treatment strategies for drug-resistant epilepsy in children with Tuberous Sclerosis Complex.
    Epilepsy & behavior : E&B, 2016, Volume: 63

    Topics: Anticonvulsants; Carbamazepine; Child; Cost-Benefit Analysis; Diet, Ketogenic; Drug Resistant Epilep

2016
Behavioral effects and somnolence due to levetiracetam versus oxcarbazepine - a retrospective comparison study of North Indian patients with refractory epilepsy.
    Epilepsy & behavior : E&B, 2016, Volume: 64, Issue:Pt A

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Disorders of Excessive Somnolence; Drug Re

2016
Drug-resistant epilepsy in children with partial onset epilepsy treated with carbamazepine.
    The International journal of neuroscience, 2017, Volume: 127, Issue:10

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistant Epilepsy; Epilep

2017
The intoxicated EEG.
    Seizure, 2017, Volume: 45

    Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Drug Overdose; Drug Resistant Epilepsy; Electroencepha

2017
Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy.
    Epilepsy & behavior : E&B, 2017, Volume: 69

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul

2017