carbamazepine has been researched along with Down Syndrome in 7 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Males have a younger age at onset." | 1.51 | Seizures in Down Syndrome: An Update. ( Fatema, K; Rahman, MM, 2019) |
| "Patients with trisomy 21 have an increased risk for stroke, which usually stems from cardiovascular defects." | 1.46 | Brain tuberculoma, an unusual cause of stroke in a child with trisomy 21: a case report. ( Hamed, AA; Hamid, FA; Ibrahim, SA; Kheir, AEM; Yousif, BM, 2017) |
| "We report the occurrence of a tic in a boy with Down's syndrome." | 1.31 | Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome. ( Boenigk, HE; Holtmann, M; Korn-Merker, E, 2000) |
| "These seizures were usually precipitated by auditory stimuli such as sudden loud noises." | 1.29 | Reflex seizures in Down syndrome. ( Louis, S; Pueschel, SM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, MM | 1 |
| Fatema, K | 1 |
| Kheir, AEM | 1 |
| Ibrahim, SA | 1 |
| Hamed, AA | 1 |
| Yousif, BM | 1 |
| Hamid, FA | 1 |
| The, T | 1 |
| Kolla, R | 1 |
| Dawkins, F | 1 |
| Trouth, AJ | 1 |
| Pueschel, SM | 1 |
| Louis, S | 1 |
| Vanstraelen, M | 1 |
| Tyrer, SP | 1 |
| Holtmann, M | 1 |
| Korn-Merker, E | 1 |
| Boenigk, HE | 1 |
| Cooper, SA | 1 |
| Collacott, RA | 1 |
1 review available for carbamazepine and Down Syndrome
| Article | Year |
|---|---|
Rapid cycling bipolar affective disorder in people with intellectual disability: a systematic review.
Topics: Antimanic Agents; Bipolar Disorder; Carbamazepine; Down Syndrome; Humans; Intellectual Disability; L | 1999 |
6 other studies available for carbamazepine and Down Syndrome
| Article | Year |
|---|---|
Seizures in Down Syndrome: An Update.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Down Syndrome; Epilepsies, Partial; Epileps | 2019 |
Brain tuberculoma, an unusual cause of stroke in a child with trisomy 21: a case report.
Topics: Anti-Inflammatory Agents; Antitubercular Agents; Carbamazepine; Child; Dexamethasone; Diagnosis, Dif | 2017 |
Pure red cell aplasia after 13 years of sodium valproate, and bone marrow suppression after 17 years of carbamazepine.
Topics: Adult; Anticonvulsants; Bone Marrow; Carbamazepine; Down Syndrome; Drug Administration Schedule; Fem | 2004 |
Reflex seizures in Down syndrome.
Topics: Acoustic Stimulation; Adult; Carbamazepine; Cerebral Cortex; Down Syndrome; Electroencephalography; | 1993 |
Carbamazepine-induced combined phonic and motor tic in a boy with Down's syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Down Syndrome; Epilepsy, Complex Partial; Humans; Male; Tics | 2000 |
Manic episodes in Down's syndrome: two case reports.
Topics: Adult; Bipolar Disorder; Carbamazepine; Down Syndrome; Humans; Lithium; Male; Middle Aged | 1991 |