carbamazepine has been researched along with Disease Models, Animal in 249 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the anticonvulsant and neuroprotective effects of carbamazepine (CBZ), levetiracetam (LEV), and CBZ + LEV adjunctive treatment in convulsive status epilepticus (CSE) rat model." | 8.02 | Anticonvulsant and neuroprotective effects of carbamazepine-levetiracetam adjunctive treatment in convulsive status epilepticus rat model: Inhibition of cholinergic transmission. ( Abdulwahab, UF; Adedokun, KI; Adekomi, AD; Akanji, NO; Olayiwola, G; Osuntokun, OS, 2021) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 7.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "Carbamazepine (CBZ) with piperine, the active ingredient in black pepper, which is omnipresent in food and may be potentially used for epilepsy control owing to its anticonvulsant effects, can be coadministered to epileptic patients." | 7.91 | Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats. ( Cheng, Y; Hu, M; Ren, T; Xiao, M; Xu, H; Yan, X; Yang, M; Zhang, C; Zhang, Y; Zhao, J; Zuo, Z, 2019) |
| "To investigate the effect and mechanisms of carbamazepine (CBZ) on the onset and progression of amyotrophic lateral sclerosis (ALS) in SOD1-G93A mouse model." | 7.88 | Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. ( Chen, S; Le, WD; Zhang, JJ; Zhou, QM, 2018) |
| "BACKGROUND This study was proposed to compare the efficacy and safety of GTM-1, Rapamycin (Rap), and Carbamazepine (CBZ) in managing Alzheimer disease (AD)." | 7.85 | Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease. ( Che, H; Fu, P; Gao, Y; Pan, Y; Wang, L; Wang, R; Zhang, L, 2017) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 7.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "Lithium (LiCl) and carbamazepine (CBZ), the common mood stabilizers, are thought to be effective treatments for bipolar disorder." | 7.79 | Effects of lithium and carbamazepine on spatial learning and depressive behavior in a rat model of bipolar disorder induced by ouabain. ( Huang, AC; Huang, CL; Wang, CC; Wang, EN; Wang, YC, 2013) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 7.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "The present study evaluated the effectiveness of intraperitoneal (IP) injections and oral administration of carbamazepine (CBZ) in food on the frequency of spontaneous motor seizures in rats with kainate-induced epilepsy." | 7.74 | Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols. ( Clark, S; Dudek, FE; Grabenstatter, HL, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 7.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "The use of carbamazepine has been reported to be an effective treatment for severe depression." | 7.74 | Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? ( Akiyama, K; Araki, H; Gomita, Y; Kawasaki, H; Kitagawa, K; Kitamura, Y; Sendo, T; Shibata, K; Suemaru, K, 2008) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 7.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 7.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 7.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 7.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 7.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix." | 5.72 | The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 ( Bateman, JF; Blank, M; Crimeen-Irwin, B; Gooi, JH; Kung, LHW; Lamandé, SR; McGregor, NE; Poulton, IJ; Rowley, L; Sims, NA; Walker, EC, 2022) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 5.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "Facial allodynia was assessed using von Frey test." | 5.56 | LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA. ( da Silva Torres, IL; de Oliveira, CL; de Oliveira, FF; de Souza, A; de Souza, VS; Lopes, BC; Marques, LX; Medeiros, LF, 2020) |
| "Almost all seizure durations were >20 seconds." | 5.51 | Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy. ( Dudek, FE; Grabenstatter, HL, 2019) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Seizures were prevented in 50% and 75% of the animals by chronic CBZ and VPC, respectively." | 5.35 | Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. ( Nekrassov, V; Sitges, M, 2008) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 5.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "ADD and seizure severity were also measured in response to both threshold and suprathreshold kindling stimulation." | 5.31 | Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute carbamazepine. ( Gilbert, TH; Teskey, GC, 2001) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " As with carbamazepine (CBZ), these findings suggest clinical efficacy against generalized tonic-clonic and, to some extent, partial seizures." | 4.79 | Oxcarbazepine: mechanisms of action. ( Feldmann, KF; McLean, MJ; Olpe, HR; Portet, C; Schmutz, M; Wamil, AW, 1994) |
| " This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation. ( Bojar, H; Chmielewski, J; Florek-Łuszczki, M; Jankiewicz, K; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "This study evaluated the anticonvulsant and neuroprotective effects of carbamazepine (CBZ), levetiracetam (LEV), and CBZ + LEV adjunctive treatment in convulsive status epilepticus (CSE) rat model." | 4.02 | Anticonvulsant and neuroprotective effects of carbamazepine-levetiracetam adjunctive treatment in convulsive status epilepticus rat model: Inhibition of cholinergic transmission. ( Abdulwahab, UF; Adedokun, KI; Adekomi, AD; Akanji, NO; Olayiwola, G; Osuntokun, OS, 2021) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 3.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "Newly diagnosed rats with epilepsy were treated with carbamazepine (CBZ) during a 4-week baseline period to establish their baseline seizure rate in the presence of 50% adherence." | 3.91 | Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence. ( Hill, AC; Newell, TG; Thomson, KE; White, HS, 2019) |
| "Carbamazepine (CBZ) with piperine, the active ingredient in black pepper, which is omnipresent in food and may be potentially used for epilepsy control owing to its anticonvulsant effects, can be coadministered to epileptic patients." | 3.91 | Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats. ( Cheng, Y; Hu, M; Ren, T; Xiao, M; Xu, H; Yan, X; Yang, M; Zhang, C; Zhang, Y; Zhao, J; Zuo, Z, 2019) |
| " Acute amiodarone at the dose of 75 mg/kg significantly potentiated the anticonvulsive effect of carbamazepine, but not that of valproate, phenytoin or phenobarbital in the maximal electroshock-induced seizures in mice." | 3.88 | Amiodarone, a multi-channel blocker, enhances anticonvulsive effect of carbamazepine in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2018) |
| "To investigate the effect and mechanisms of carbamazepine (CBZ) on the onset and progression of amyotrophic lateral sclerosis (ALS) in SOD1-G93A mouse model." | 3.88 | Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. ( Chen, S; Le, WD; Zhang, JJ; Zhou, QM, 2018) |
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| "The results from this pilot investigation suggest that nonadherence to carbamazepine is associated with significant negative but reversible effects on seizure control in an animal model of epilepsy." | 3.85 | The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy. ( Glauser, TA; Modi, AC; Rausch, JR; Steve White, H; Thomson, KE, 2017) |
| "BACKGROUND This study was proposed to compare the efficacy and safety of GTM-1, Rapamycin (Rap), and Carbamazepine (CBZ) in managing Alzheimer disease (AD)." | 3.85 | Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease. ( Che, H; Fu, P; Gao, Y; Pan, Y; Wang, L; Wang, R; Zhang, L, 2017) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| "The aim of this study was to determine the effects of 2-methyl-6-(phenylethynyl)pyridine (MPEP - a selective antagonist for the glutamate metabotropic receptor subtype mGluR5) on the protective action of some novel antiepileptic drugs (lamotrigine, oxcarbazepine, pregabalin and topiramate) against maximal electroshock-induced seizures in mice." | 3.83 | Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Zolkowska, D, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| ") gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE)." | 3.83 | Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. ( Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E, 2016) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "The natural compounds carvacrol and thymol completely prevented seizures in the 6 Hz, 32 mA partial seizure model." | 3.80 | Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model. ( Baker, MT; Mishra, RK, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 3.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "These results demonstrate a behaviourally effective oral and chronic regimen for carbamazepine with mood stabilising-like activity in a standard model for mania-like behaviour and two standard models for depression-like behaviour." | 3.80 | Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. ( Agam, G; Belmaker, RH; Einat, H; Kara, NZ; Karpel, O; Toker, L, 2014) |
| " We tested the hypothesis that status epilepticus (SE) or exposure to phenytoin or phenobarbital affects brain expression of the metabolic enzyme CYP2E1." | 3.80 | Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. ( Boussadia, B; de Bock, F; Ghosh, C; Janigro, D; Marchi, N; Pascussi, JM; Plaud, C; Rousset, MC, 2014) |
| "Lithium (LiCl) and carbamazepine (CBZ), the common mood stabilizers, are thought to be effective treatments for bipolar disorder." | 3.79 | Effects of lithium and carbamazepine on spatial learning and depressive behavior in a rat model of bipolar disorder induced by ouabain. ( Huang, AC; Huang, CL; Wang, CC; Wang, EN; Wang, YC, 2013) |
| " Intracisternal strychnine in rats has been shown to result in localized trigeminal dynamic allodynia, thus representing a possible model of trigeminal neuralgia." | 3.79 | Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia. ( Lee, IO; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Whitehead, RA, 2013) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 3.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| "The aim of this work was to analyze the effect of oxcarbazepine (OXC) on sleep patterns, "head and body shakes" and monoamine neurotransmitters level in a model of kainic-induced seizures." | 3.77 | Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats. ( Alfaro-Rodríguez, A; Arch-Tirado, E; Ávila-Luna, A; Bueno-Nava, A; González-Piña, R; Uribe-Escamilla, R; Vargas-Sánchez, J, 2011) |
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| "Carbamazepine (Carba) is an anticonvulsant and psychotropic drug used widely for the treatment of intellectual disability and severe pains, but the incidence of hyponatremia is a common related occurrence." | 3.76 | Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression. ( de Bragança, AC; Magaldi, AJ; Moyses, ZP, 2010) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "The successful use of antiepileptic drugs to treat a wide range of nonepileptic disorders led us to evaluate the potential efficacy of carbamazepine (CBZ) in anxiety disorders." | 3.75 | Role of ventral hippocampal GABA(A) and NMDA receptors in the anxiolytic effect of carbamazepine in rats using the elevated plus maze test. ( Bina, P; Rezvanfard, M; Zarrindast, MR, 2009) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "The present study evaluated the effectiveness of intraperitoneal (IP) injections and oral administration of carbamazepine (CBZ) in food on the frequency of spontaneous motor seizures in rats with kainate-induced epilepsy." | 3.74 | Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols. ( Clark, S; Dudek, FE; Grabenstatter, HL, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 3.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "The use of carbamazepine has been reported to be an effective treatment for severe depression." | 3.74 | Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? ( Akiyama, K; Araki, H; Gomita, Y; Kawasaki, H; Kitagawa, K; Kitamura, Y; Sendo, T; Shibata, K; Suemaru, K, 2008) |
| "There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain." | 3.74 | The antinociceptive effects of anticonvulsants in a mouse visceral pain model. ( Boskovic, B; Milovanovic, S; Paranos, S; Prostran, MS; Stepanovic-Petrovic, RM; Tomic, MA; Ugresic, ND; Vuckovic, SM, 2008) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| " Following pilocarpine-induced status epilepticus interrupted after 4h, rats were continuously videorecorded for onset and recurrence of spontaneous convulsive seizures." | 3.73 | Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. ( Bentivoglio, M; Chakir, A; Fabene, PF; Ouazzani, R, 2006) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 3.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 3.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "The effect of oxcarbazepine was evaluated in two tests of depression (forced swimming and learned helplessness) and in the open-field test." | 3.70 | The effect of oxcarbazepine on behavioural despair and learned helplessness. ( Andreatini, R; Beijamini, V; Joca, SR; Skalisz, LL, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 3.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| " In a thromboplastin-induced thromboembolism model, administration of 30 mg/kg YM-75466 or 3 mg/kg warfarin significantly improved the lethality ratio." | 3.70 | Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. ( Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y, 1998) |
| "To investigate the relationships between carbamazepine (CBZ) concentrations in serum and the brain, and the anticonvulsive efficacy in kainic acid (KA) induced seizures in rats, adult Wistar rats (n=25) were intraperitoneally given 40 mg/kg CBZ, followed by 15 mg/kg KA (n=20) or saline (control, n=5)." | 3.70 | Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats. ( Wang, L; Wu, XR; Zhao, DY; Zuo, CH, 2000) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats." | 3.69 | Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "A major challenge in the treatment of bipolar depression is the tendency for antidepressant medications, particularly tricyclic antidepressants, to precipitate episodes of mania, or to increase cycle frequency or symptom intensity." | 2.44 | The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders. ( Bourin, M; Prica, C, 2007) |
| "Oxcarbazepine (OXC) was developed to provide a compound chemically similar enough to CBZ to mimic its efficacy and overall safety while improving its side-effect profile." | 2.40 | Oxcarbazepine. ( Tecoma, ES, 1999) |
| "Trigeminal neuralgia is unilateral, lancinating, episodic pain that can be provoked by routine activities." | 1.72 | Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis. ( Ikutame, D; Iwasa, T; Matsuka, Y; Okura, K; Oshima, M; Raju, R; Raman, S; Waskitho, A, 2022) |
| "The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix." | 1.72 | The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 ( Bateman, JF; Blank, M; Crimeen-Irwin, B; Gooi, JH; Kung, LHW; Lamandé, SR; McGregor, NE; Poulton, IJ; Rowley, L; Sims, NA; Walker, EC, 2022) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| "The antiseizure drug, carbamazepine (CBZ), and the antiabsence drug, ethosuximide (ETX), were administered separately to determine if they selectively suppressed unilateral- versus bilateral-onset SWDs, respectively." | 1.62 | Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury. ( Barth, DS; Dudek, FE; Poulsen, DJ; Smith, ZZ; Tatum, S; Taylor, JA, 2021) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "The present study aims to evaluate the efficacy of selenium (Se) alone or combined with carbamazepine (CBZ) against the adverse effects induced by the chemoconvulsant pentylenetetrazole (PTZ) in the cortex of adult male rats." | 1.56 | Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy. ( Aboul Ezz, HS; Ali, MA; Mohammed, HS; Zedan, A, 2020) |
| "Five groups of each of 12 female rats were orally dosed daily for 8 weeks with either carbamazepine (CBZ) (60 mg/kg), eslicarbazepine (ESL) (80 mg/kg), valproic acid (VPA) (300 mg/kg), levetiracetam (LEV) (50 mg/kg) or saline (control (CTL))." | 1.56 | Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats. ( Andersen, NB; Diemar, SS; Ding, M; Eiken, P; Ellegaard, M; Jørgensen, NR; Sejling, AS, 2020) |
| "Facial allodynia was assessed using von Frey test." | 1.56 | LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA. ( da Silva Torres, IL; de Oliveira, CL; de Oliveira, FF; de Souza, A; de Souza, VS; Lopes, BC; Marques, LX; Medeiros, LF, 2020) |
| "Almost all seizure durations were >20 seconds." | 1.51 | Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy. ( Dudek, FE; Grabenstatter, HL, 2019) |
| "Electrically-induced tonic-clonic seizures were experimentally evoked in adult male albino Swiss mice." | 1.51 | New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. ( Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ, 2019) |
| "The severe sole effects of seizures on the cortical part of bone were reported in our previous study." | 1.48 | Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy. ( Boskey, AL; Evis, Z; Garip Ustaoglu, S; Ilbay, G; Severcan, F, 2018) |
| "This study evaluated the protective effects of CDDP alone and in combination with carbamazepine (CBZ) on kainic acid-induced TLE and cognitive impairment in rats." | 1.48 | Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats. ( Cao, B; Chen, M; Dang, X; Han, S; Jia, C; Jiao, H; Liu, Y; Niu, Q; Wei, L, 2018) |
| "This formulation reduced systemic exposure to carbamazepine over 1,000-fold relative to traditional analgesic dosing regimens." | 1.48 | Opiate-Free Pain Therapy Using Carbamazepine-Loaded Microparticles Provides Up to 2 Weeks of Pain Relief in a Neuropathic Pain Model. ( Dai, H; Doherty, C; Gulati, A; Holzhaus, K; Khalil, A; Mehta, N; Mercedes, G; Reynolds, FM; Tilley, DM, 2018) |
| "Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE])." | 1.46 | Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy. ( Aroni, S; Marrosu, F; Melis, M; Milioli, G; Muntoni, AL; Parrino, L; Pillolla, G; Pistis, M; Puligheddu, M; Sagheddu, C; Terzano, GM, 2017) |
| "Adequate control of seizures remains an unmet need in epilepsy." | 1.43 | Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols. ( Gunia-Krzyżak, A; Koczurkiewicz, P; Marona, H; Nitek, W; Pękala, E; Szkaradek, N; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E, 2016) |
| "Carbamazepine (CBZ) is an anticonvulsant drug, prescribed worldwide for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia, which has been frequently detected in aquatic environments." | 1.43 | Effects of carbamazepine on cortisol levels and behavioral responses to stress in the fish Jenynsia multidentata. ( Bistoni, Mde L; Calcagno, E; Durando, P; Franchioni, L; Valdés, ME, 2016) |
| " Type I isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to analyze the 3-drug combination." | 1.43 | Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model. ( Luszczki, JJ, 2016) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "Eslicarbazepine acetate is a recently approved antiepileptic drug that is rapidly metabolized to (S)-licarbazepine." | 1.42 | Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsy. ( Kim, TH; Petrou, S; Reid, CA, 2015) |
| " Testing of biological activity revealed limited potential for resistance to these agents, low toxicity, and highly effective in vivo activity, even with low dosing regimens." | 1.40 | Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines. ( Burda, WN; Fleeman, R; Manetsch, R; Shaw, LN; Van Horn, KS, 2014) |
| "Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32mA, 6Hz, 3s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the various drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10." | 1.40 | Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - a type II isobolographic analysis. ( Florek-Luszczki, M; Luszczki, JJ; Wlaz, A, 2014) |
| "Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a partial sleep-related epilepsy which can be caused by mutant neuronal nicotinic acetylcholine receptors (nAChR)." | 1.40 | Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy. ( Becchetti, A; Casari, G; Gullo, F; Lecchi, M; Manfredi, I; Wanke, E, 2014) |
| "Carbamazepine was used as a positive control." | 1.39 | The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. ( Andreatini, R; Biojone, C; Casarotto, PC; Correia, D; Guimarães, FS; Joca, SL; Martynhak, BJ; Pereira, M; Siba, IP; Tonelli, DA, 2013) |
| " Fluoxetine (FLX), an SSRI on chronic administration (10mg/kg, 21 days) restored the increase in SAB induced by 8-OHDPAT in mice which is in line with the findings earlier reported for rats." | 1.39 | Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway. ( Arora, T; Bhowmik, M; Khanam, R; Vohora, D, 2013) |
| "The selected neuropathic pain model was the spared nerve injury (SNI) model and the endpoints were burrowing and measures of paw posture in Sprague Dawley rats." | 1.39 | A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain. ( de Lannoy, IA; Dykstra, C; Higgins, GA; Lau, W; Lee, DK; Silenieks, LB; Thevarkunnel, S, 2013) |
| "Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments." | 1.39 | Neuroprotection in a novel mouse model of multiple sclerosis. ( Ahmed, Z; Baker, D; Baker, MD; Coffey, P; Giovannoni, G; Jackson, SJ; Lidster, K; Munro, P, 2013) |
| " Since rapamycin is also an immune suppressor, there is a concern that long-term use of rapamycin may bring severe unwanted side effects." | 1.39 | Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease. ( Le, W; Li, L; Li, T; Liu, H; Tang, Y; Yang, W; Zhang, S; Zhang, X, 2013) |
| " Additionally, the effects of acute and chronic administration of both statins on the adverse effect potential of three antiepileptic drugs were assessed in the chimney test (motor performance) and passive avoidance task (long-term memory)." | 1.38 | The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Stepien, KM; Tomaszewski, M, 2012) |
| " Similar pharmacokinetic changes were observed in HL rats after oral administration of CBZ." | 1.38 | Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase. ( Kang, HE; Kim, SG; Kim, YW; Lee, I; Lee, MG; Lee, YS, 2012) |
| "ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures." | 1.38 | Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. ( Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A, 2012) |
| " The acute actions of these drugs are well known but the effects of long-term use on partially induced epileptiform characteristics are yet to be clarified." | 1.38 | Chronic application of topiramate and carbamazepine differentially affects the EEG and penicillin-induced epileptiform activity in rats. ( Abidin, İ; Aydin-Abidin, S; Cansu, A; Yildirim, M, 2012) |
| "Carbamazepine (CBZ) is a commonly used antiepileptic that is metabolized by CYP3A isoforms." | 1.38 | Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. ( Jang, HC; Lee, EK; Lee, YK; Moore, DD; Park, DJ; Park, YJ, 2012) |
| "Carbamazepine (CBZ) is a widely used antiepileptic agent." | 1.38 | Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury. ( Fukami, T; Higuchi, S; Nakajima, M; Takai, S; Tsuneyama, K; Yano, A; Yokoi, T, 2012) |
| "The percentage allodynia relief was only 60% for carbamazepine and 80% for pregabalin by single administration, whereas their co-administration relieved allodynia by 100%." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system." | 1.37 | Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. ( Arjun, M; Menon, N; Semwal, A; Sriram, D; Yogeeswari, P, 2011) |
| " To conclude, long term administration of topiramate impairs cognitive functions during experimental epilepsy while lamotrigine and oxcarbazepine are safer." | 1.37 | Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. ( Agarwal, NB; Agarwal, NK; Mediratta, PK; Sharma, KK, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], oxcarbazepine [OXC], pregabalin [PGB], and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis. ( Antkiewicz-Michaluk, L; Czuczwar, SJ; Luszczki, JJ; Raszewski, G, 2010) |
| "To characterize the anticonvulsant effects of pregabalin (PGB - a third-generation antiepileptic drug) in combination with carbamazepine (CBZ - a classical antiepileptic drug) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2010) |
| " Piperine (20 mg/kg orally) was administered along with curcumin to enhance the bioavailability of the latter up to 20-fold more." | 1.36 | Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. ( Jyothy, A; Munshi, A; Nehru, B; Sharma, V, 2010) |
| ", lamotrigine [LTG], oxcarbazepine [OXC] and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| " The isobolographic analysis for parallel and nonparallel dose-response effects was used in the mouse maximal electroshock seizure (MES) model for evaluation of pharmacodynamic interaction." | 1.35 | Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ, 2009) |
| "Seizures were prevented in 50% and 75% of the animals by chronic CBZ and VPC, respectively." | 1.35 | Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. ( Nekrassov, V; Sitges, M, 2008) |
| "Spinal cord ischemia was induced by infrarenal aortic crossclamp for 25 minutes in both groups." | 1.35 | Effects of carbamazepine on spinal cord ischemia. ( Bahadir Inan, M; Besalti, O; Elhan, AH; Erdemli, E; Eryilmaz, S; Kaya, B; Ozcinar, E; Ozyurda, U; Sirin, YS; Sirlak, M; Tasoz, R; Yazicioglu, L, 2008) |
| "Temporal lobe epilepsy is one of the most common types of epilepsy." | 1.35 | Effect of oxcarbazepine pretreatment on convulsive activity and brain damage induced by kainic acid administration in rats. ( Ayala-Guerrero, F; Campos-Sepúlveda, E; González-Maciel, A; Mexicano, G; Reynoso-Robles, R; Romero, RM, 2008) |
| "Bicuculline alone did not produce an intrinsic effect in the paw-pressure test." | 1.35 | GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia. ( Bosković, B; Kocev, N; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2008) |
| " However, these combinations were associated with significant pharmacokinetic interactions, in that LCZ increased brain TPM (94%), OXC (21%), FBM (46%), and LTG (8%) concentrations." | 1.33 | Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| " Brain AED concentrations were determined to ascertain any pharmacokinetic contribution to the observed antiseizure effect." | 1.33 | Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis. ( Andres, MM; Cioczek-Czuczwar, A; Czuczwar, P; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "Previous studies have demonstrated that pharmacokinetic behavior of several drugs such as paracetamol, theophylline, and aminoglycosides are significantly altered in patients with spinal cord injury." | 1.33 | The influence of experimental spinal cord injury on carbamazepine pharmacokinetics. ( Ansari, M; Karamousian, S; Reihani-Kermani, H, 2006) |
| "Carbamazepine (CBZ) is a commonly used antiepileptic drug known to block voltage-gated sodium channels." | 1.33 | Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse. ( Josephsson, A; Klason, T; Lavebratt, C; Ohman, I; Olson, L; Persson, AS; Schalling, M; Spenger, C; Trifunovski, A; Wang, FH, 2006) |
| "With pentylenetetrazol (PTZ) induced seizures pre-treated by CBZ, or SR-3, both CBZ and SR-3 were equally effective in providing seizure control and both were superior to the saline control." | 1.32 | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). ( Mostofsky, DI; Rabinovitz, S; Yehuda, S, 2004) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 1.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| "Carbamazepine (100 mg/kg) was weakly effective against all the responses." | 1.31 | Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain. ( Field, MJ; Gonzalez, MI; Hughes, J; Singh, L, 2000) |
| "ADD and seizure severity were also measured in response to both threshold and suprathreshold kindling stimulation." | 1.31 | Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute carbamazepine. ( Gilbert, TH; Teskey, GC, 2001) |
| " AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used." | 1.30 | AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997) |
| " For comparison of drug potencies, doses increasing seizure thresholds by 20 or 50% were calculated from dose-response curves." | 1.30 | Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models. ( Krupp, E; Löscher, W, 1998) |
| "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant." | 1.29 | Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993) |
| "Treatment of phenytoin responders and nonresponders with other primary antiepileptic drugs showed that valproate and phenobarbital induced much smaller increases in focal seizure threshold in phenytoin nonresponders than in responders, whereas carbamazepine induced about the same threshold increase in both groups." | 1.29 | Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993) |
| "D-Cycloserine (DCS) is a high-efficacy partial agonist at the strychnine-insensitive glycine modulatory site within the N-methyl-D-aspartate (NMDA)-receptor/ionophore complex." | 1.29 | Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. ( Czuczwar, SJ; Roliński, Z; Wlaź, P, 1996) |
| "Treatment with carbamazepine attenuated (P less than 0." | 1.28 | Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine. ( Browne, TR; Galpern, WR; Greenblatt, DJ; Miller, LG; Shader, RI; Szabo, GK, 1991) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " Subacute and chronic administration of imipramine (4 or 15 mg/kg) decreased immobility of rats in the behavioral despair model." | 1.27 | The effects of carbamazepine on two animal models of depression. ( Barros, HM; Leite, JR, 1987) |
| "Carbamazepine and phenytoin were ineffective or aggravated the seizures." | 1.27 | Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. ( Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| ", 1974), the problem of its low bioavailability in solid form and its short half-life in monkey were addressed." | 1.26 | Carbamazepine revisited in a monkey model. ( Congdon, WC; DuCharme, LL; Levy, RH; Lockard, JS; Patel, IH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (7.23) | 18.7374 |
| 1990's | 30 (12.05) | 18.2507 |
| 2000's | 64 (25.70) | 29.6817 |
| 2010's | 113 (45.38) | 24.3611 |
| 2020's | 24 (9.64) | 2.80 |
| Authors | Studies |
|---|---|
| Hallot, A | 1 |
| Brodin, R | 1 |
| Merlier, J | 1 |
| Brochard, J | 1 |
| Chambon, JP | 1 |
| Biziere, K | 1 |
| Xie, ZF | 1 |
| Chai, KY | 2 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 4 |
| Yogeeswari, P | 2 |
| Ragavendran, JV | 1 |
| Sriram, D | 2 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Guan, LP | 2 |
| Sui, X | 1 |
| Deng, XQ | 1 |
| Quan, YC | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Menon, N | 1 |
| Semwal, A | 1 |
| Arjun, M | 1 |
| Rajak, H | 1 |
| Singh Thakur, B | 1 |
| Singh, A | 1 |
| Raghuvanshi, K | 1 |
| Sah, AK | 1 |
| Veerasamy, R | 1 |
| Sharma, PC | 1 |
| Singh Pawar, R | 1 |
| Kharya, MD | 1 |
| Malik, S | 1 |
| Bahare, RS | 1 |
| Khan, SA | 1 |
| Van Horn, KS | 1 |
| Burda, WN | 1 |
| Fleeman, R | 1 |
| Shaw, LN | 1 |
| Manetsch, R | 2 |
| Wang, SB | 1 |
| Jin, P | 1 |
| Li, FN | 1 |
| Mishra, RK | 1 |
| Baker, MT | 1 |
| Kamiński, K | 3 |
| Rapacz, A | 4 |
| Łuszczki, JJ | 8 |
| Latacz, G | 2 |
| Obniska, J | 2 |
| Kieć-Kononowicz, K | 2 |
| Filipek, B | 2 |
| Zagaja, M | 3 |
| Andres-Mach, M | 3 |
| Tanaka, T | 1 |
| Yajima, N | 1 |
| Tanitame, A | 1 |
| Kiyoshi, T | 1 |
| Miura, Y | 1 |
| Edayadulla, N | 1 |
| Ramesh, P | 1 |
| Gunia-Krzyżak, A | 2 |
| Żesławska, E | 2 |
| Słoczyńska, K | 2 |
| Koczurkiewicz, P | 1 |
| Nitek, W | 2 |
| Żelaszczyk, D | 2 |
| Szkaradek, N | 1 |
| Waszkielewicz, AM | 2 |
| Pękala, E | 2 |
| Marona, H | 2 |
| Abram, M | 1 |
| Pańczyk, K | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Monastyrskyi, A | 1 |
| Brockmeyer, F | 1 |
| LaCrue, AN | 1 |
| Zhao, Y | 1 |
| Maher, SP | 1 |
| Maignan, JR | 1 |
| Padin-Irizarry, V | 1 |
| Sakhno, YI | 1 |
| Parvatkar, PT | 1 |
| Asakawa, AH | 1 |
| Huang, L | 1 |
| Casandra, D | 1 |
| Mashkouri, S | 1 |
| Kyle, DE | 1 |
| Raman, S | 1 |
| Waskitho, A | 1 |
| Raju, R | 1 |
| Iwasa, T | 1 |
| Ikutame, D | 1 |
| Okura, K | 1 |
| Oshima, M | 1 |
| Matsuka, Y | 1 |
| Blank, M | 1 |
| McGregor, NE | 1 |
| Rowley, L | 1 |
| Kung, LHW | 1 |
| Crimeen-Irwin, B | 1 |
| Poulton, IJ | 1 |
| Walker, EC | 1 |
| Gooi, JH | 1 |
| Lamandé, SR | 1 |
| Sims, NA | 1 |
| Bateman, JF | 1 |
| Borowicz-Reutt, K | 2 |
| Banach, M | 7 |
| Bernat, P | 1 |
| Kołodziejczyk, P | 2 |
| Tutka, P | 2 |
| Bojar, H | 1 |
| Jankiewicz, K | 1 |
| Florek-Łuszczki, M | 2 |
| Chmielewski, J | 2 |
| Skalicka-Woźniak, K | 1 |
| Boboc, IKS | 1 |
| Cojocaru, A | 1 |
| Nedelea, G | 1 |
| Catalin, B | 1 |
| Bogdan, M | 1 |
| Calina, D | 1 |
| Pan, RY | 1 |
| Chu, MT | 1 |
| Wang, CW | 1 |
| Lee, YS | 2 |
| Lemonnier, F | 1 |
| Michels, AW | 1 |
| Schutte, R | 1 |
| Ostrov, DA | 1 |
| Chen, CB | 1 |
| Phillips, EJ | 1 |
| Mallal, SA | 1 |
| Mockenhaupt, M | 1 |
| Bellón, T | 1 |
| Tassaneeyakul, W | 1 |
| White, KD | 1 |
| Roujeau, JC | 1 |
| Chung, WH | 1 |
| Hung, SI | 1 |
| Mohammed, HS | 1 |
| Aboul Ezz, HS | 1 |
| Zedan, A | 1 |
| Ali, MA | 1 |
| Zavala-Tecuapetla, C | 1 |
| Orozco-Suarez, S | 1 |
| Manjarrez, J | 1 |
| Cuellar-Herrera, M | 1 |
| Vega-Garcia, A | 1 |
| Buzoianu-Anguiano, V | 1 |
| Qushawy, M | 1 |
| Prabahar, K | 1 |
| Abd-Alhaseeb, M | 1 |
| Swidan, S | 1 |
| Nasr, A | 1 |
| Borowicz-Reutt, KK | 4 |
| Rudkowska, M | 1 |
| Diemar, SS | 1 |
| Sejling, AS | 1 |
| Eiken, P | 1 |
| Ellegaard, M | 1 |
| Ding, M | 1 |
| Andersen, NB | 1 |
| Jørgensen, NR | 1 |
| de Oliveira, CL | 1 |
| Medeiros, LF | 1 |
| de Souza, VS | 1 |
| Lopes, BC | 1 |
| de Oliveira, FF | 1 |
| Marques, LX | 1 |
| da Silva Torres, IL | 1 |
| de Souza, A | 1 |
| El-Sherbeeny, NA | 1 |
| Ibrahiem, AT | 1 |
| Ali, HS | 1 |
| Farag, NE | 1 |
| Toraih, EA | 1 |
| Zaitone, SA | 1 |
| Koneval, Z | 1 |
| Knox, KM | 1 |
| Memon, A | 1 |
| Zierath, DK | 1 |
| White, HS | 7 |
| Barker-Haliski, M | 1 |
| Łukawski, K | 1 |
| Raszewski, G | 3 |
| Czuczwar, SJ | 20 |
| Hamelin, S | 1 |
| Stupar, V | 1 |
| Mazière, L | 1 |
| Guo, J | 1 |
| Labriji, W | 1 |
| Liu, C | 1 |
| Bretagnolle, L | 1 |
| Parrot, S | 1 |
| Barbier, EL | 1 |
| Depaulis, A | 2 |
| Fauvelle, F | 1 |
| Ajaman, M | 1 |
| Naserzadeh, R | 1 |
| Ghorbanzadeh, B | 2 |
| Tatum, S | 1 |
| Smith, ZZ | 1 |
| Taylor, JA | 1 |
| Poulsen, DJ | 1 |
| Dudek, FE | 4 |
| Barth, DS | 1 |
| Bertram, EH | 1 |
| Edelbroek, P | 1 |
| Osuntokun, OS | 1 |
| Abdulwahab, UF | 1 |
| Akanji, NO | 1 |
| Adedokun, KI | 1 |
| Adekomi, AD | 1 |
| Olayiwola, G | 1 |
| Cho, SJ | 1 |
| Park, E | 1 |
| Baker, A | 1 |
| Reid, AY | 1 |
| Thomson, KE | 3 |
| Modi, AC | 1 |
| Glauser, TA | 1 |
| Rausch, JR | 1 |
| Steve White, H | 2 |
| Mante, PK | 1 |
| Adongo, DW | 1 |
| Woode, E | 1 |
| Valero, M | 1 |
| Averkin, RG | 2 |
| Fernandez-Lamo, I | 1 |
| Aguilar, J | 1 |
| Lopez-Pigozzi, D | 1 |
| Brotons-Mas, JR | 1 |
| Cid, E | 1 |
| Tamas, G | 1 |
| Menendez de la Prida, L | 2 |
| Puligheddu, M | 1 |
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| Pillolla, G | 1 |
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| Terzano, GM | 1 |
| Aroni, S | 1 |
| Sagheddu, C | 1 |
| Marrosu, F | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Garip Ustaoglu, S | 1 |
| Evis, Z | 1 |
| Ilbay, G | 1 |
| Boskey, AL | 1 |
| Severcan, F | 1 |
| Popławska, M | 1 |
| Jia, C | 1 |
| Han, S | 1 |
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| Zhou, QM | 1 |
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| Paulose, CS | 4 |
| Lee, IO | 1 |
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| Agam, G | 1 |
| Belmaker, RH | 2 |
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| Eun, JW | 1 |
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| Shen, Q | 1 |
| Park, SJ | 1 |
| Kim, HS | 1 |
| Shin, WC | 1 |
| Yang, HD | 1 |
| Jin, CY | 1 |
| You, JS | 1 |
| Kang, HJ | 1 |
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| Park, WS | 1 |
| Lee, JY | 1 |
| Nam, SW | 1 |
| Boussadia, B | 1 |
| Ghosh, C | 1 |
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| Pascussi, JM | 1 |
| de Bock, F | 1 |
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| Marchi, N | 1 |
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| Löscher, W | 6 |
| Kim, TH | 1 |
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| Höcht, C | 1 |
| Lazarowski, A | 1 |
| Gonzalez, NN | 1 |
| Mayer, MA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantitative MRI and GABA Spectroscopy to Localize the Epileptic Zone[NCT06057233] | 40 participants (Anticipated) | Observational | 2024-03-31 | Not yet recruiting | |||
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| OxCarbazepine as a Neuroprotective Agent in MS: A Phase 2a Trial[NCT02104661] | Phase 2 | 30 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
15 reviews available for carbamazepine and Disease Models, Animal
| Article | Year |
|---|---|
Targeting intracellular degradation pathways for treatment of liver disease caused by α1-antitrypsin deficiency.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Autophagy; Carbamazepine; Disease Mode | 2014 |
Modulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental models.
Topics: Animals; Anticonvulsants; Antioxidants; Carbamazepine; Disease Models, Animal; Enzymes; Fructose; Hu | 2013 |
[Rational combinations of antiepileptic drugs for refractory epilepsy].
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cl | 2011 |
[Characteristics and indications of oxcarbazepine].
Topics: Animals; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Disease Models, Animal; Dose-Resp | 2002 |
New pharmacological approaches for the treatment of alcoholism.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Carbamazepine; Depression; Disease Models, Ani | 2006 |
Plasticity of antiepileptic drug targets.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Carbamazepine; Disease Models, Animal; Drug De | 2007 |
The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders.
Topics: Affective Symptoms; Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Depressive Disorder; | 2007 |
Idiopathic megalencephaly-possible cause and treatment opportunities: from patient to lab.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Epilepsy; Humans; Kv1.1 Pota | 2008 |
Oxcarbazepine: mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Disease Models, Animal; | 1994 |
Clobazam, oxcarbazepine, tiagabine, topiramate, and other new antiepileptic drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Cl | 1995 |
[Anticonvulsants can aggravate idiopathic generalized epilepsy].
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy, Ab | 1998 |
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fru | 1999 |
Oxcarbazepine.
Topics: Adult; Animals; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; Controll | 1999 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Effects of different classes of antiepileptic drugs on brain-stem pathways.
Topics: Animals; Anticonvulsants; Baclofen; Brain Stem; Carbamazepine; Disease Models, Animal; Electroshock; | 1985 |
1 trial available for carbamazepine and Disease Models, Animal
| Article | Year |
|---|---|
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
233 other studies available for carbamazepine and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Female; Furans; Humans; Hydrazones; Hyp | 2011 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; | 2013 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 2013 |
Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines.
Topics: Animals; Anti-Bacterial Agents; Diamines; Disease Models, Animal; Hemolysis; Humans; Larva; Microbia | 2014 |
Synthesis and anticonvulsant activity of novel purine derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Motor Activity; Pentylenetetra | 2014 |
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model.
Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Perfor | 2014 |
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response R | 2015 |
Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Ele | 2015 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Drug Evalu | 2016 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1
Topics: Administration, Oral; Animals; Antimalarials; Cyclization; Disease Models, Animal; Ethers; Female; H | 2021 |
Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis.
Topics: Analgesics; Animals; Biopterins; Carbamazepine; Disease Models, Animal; Hyperalgesia; Neuralgia; ort | 2022 |
The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2
Topics: Animals; Carbamazepine; Collagen; Collagen Type I; Disease Models, Animal; Humans; Male; Mice; Mutat | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2023 |
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2023 |
Chronic Administration of Ion Channel Blockers Impact Microglia Morphology and Function in a Murine Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Carbamazepine; Di | 2023 |
Identification of drug-specific public TCR driving severe cutaneous adverse reactions.
Topics: Adoptive Transfer; Adult; Aged; Animals; Carbamazepine; Disease Models, Animal; Female; HLA-B15 Anti | 2019 |
Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrodes; Electroencephalography; | 2020 |
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling.
Topics: Animals; Anticonvulsants; Brain; Capillaries; Carbamazepine; Disease Models, Animal; Drug Resistant | 2020 |
Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Compounding; Epilepsy; Humans; | 2019 |
Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal | 2020 |
Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.
Topics: Animals; Anticonvulsants; Bone and Bones; Carbamazepine; Dibenzazepines; Disease Models, Animal; Epi | 2020 |
LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA.
Topics: Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Factor; Carbamazepine; Disease Models, | 2020 |
Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia.
Topics: Alloxan; Animals; Carbamazepine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mod | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; | 2020 |
In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrophoresis, Capillary; Epileps | 2021 |
Pharmacological evaluation of NO/cGMP/KATP channels pathway in the antidepressant-like effect of carbamazepine in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Carbamazepine; Cyclic GMP; Depression; Disease Mode | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Carbamazepine; Disease Models, Animal; Electroc | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Anticonvulsant and neuroprotective effects of carbamazepine-levetiracetam adjunctive treatment in convulsive status epilepticus rat model: Inhibition of cholinergic transmission.
Topics: Acetylcholine; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Hippocampus; Levetir | 2021 |
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista | 2021 |
The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response R | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra | 2017 |
Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Waves; CA1 Region, Hippocampal; Carbamazepine; Di | 2017 |
Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Disease Models, Animal; D | 2017 |
Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcium; Carbamaze | 2018 |
Amiodarone, a multi-channel blocker, enhances anticonvulsive effect of carbamazepine in the mouse maximal electroshock model.
Topics: Amiodarone; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2018 |
Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; CA3 Region, Hippo | 2018 |
Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analgesics, Non-Narcotic; Animals; Autophagy; Beclin-1; | 2018 |
Opiate-Free Pain Therapy Using Carbamazepine-Loaded Microparticles Provides Up to 2 Weeks of Pain Relief in a Neuropathic Pain Model.
Topics: Analgesics; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dosage Forms; Hyperalge | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |
Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene.
Topics: Animals; Carbamazepine; Chondrocytes; Codon, Nonsense; Collagen Type X; Disease Models, Animal; Endo | 2018 |
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; De | 2019 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2019 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Mo | 2019 |
Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electroencephalography; Epilepsy; M | 2019 |
Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Dentate Gyrus; Disease Models, Animal; Epileps | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 2019 |
Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Brain; Carbamazepine; Cytochrome P-450 Enzyme In | 2019 |
Effects of lithium and carbamazepine on spatial learning and depressive behavior in a rat model of bipolar disorder induced by ouabain.
Topics: Animals; Bipolar Disorder; Carbamazepine; Depression; Disease Models, Animal; Learning; Lithium; Mal | 2013 |
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2013 |
Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carbamazepine; Cerebral Cortex; Cyclic AMP Respons | 2013 |
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; C | 2013 |
Evaluation of a novel mouse model of intracisternal strychnine-induced trigeminal allodynia.
Topics: Analgesics, Non-Narcotic; Animals; Carbamazepine; Cerebrospinal Fluid; Cisterna Magna; Disease Model | 2013 |
A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain.
Topics: Animals; Behavior, Animal; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Biophysics; Carbamazepine; Disease Models, Animal; Dose | 2013 |
Liver: Carbamazepine accelerates liver regeneration in mice after acute injury.
Topics: Analgesics, Non-Narcotic; Animals; Carbamazepine; Chemical and Drug Induced Liver Injury; Disease Mo | 2013 |
Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - a type II isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Drug Combinatio | 2014 |
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Diseas | 2014 |
Neuroprotection in a novel mouse model of multiple sclerosis.
Topics: Animals; Anticonvulsants; Carbamazepine; Caspase 2; Disease Models, Animal; Evoked Potentials, Visua | 2013 |
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Ethosuximide; Female; F | 2013 |
P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2013 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Respons | 2014 |
Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Carbamates; Carbamazepine; Dis | 2014 |
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle | 2014 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Biophysics; Carbamazepine; Convulsants; Disease Models, Animal; Electric S | 2014 |
Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; C | 2014 |
Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice.
Topics: Administration, Oral; Affect; Animals; Bipolar Disorder; Carbamazepine; Depression; Disease Models, | 2014 |
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
Topics: Animals; Biomarkers; Carbamazepine; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease | 2015 |
A novel open-source drug-delivery system that allows for first-of-kind simulation of nonadherence to pharmacological interventions in animal disease models.
Topics: Animals; Anticonvulsants; Carbamazepine; Computers; Disease Models, Animal; Drug Delivery Systems; E | 2014 |
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Central Nervous | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsy.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Carbamazepine; Dibenzazepines; Disease Models, Animal; | 2015 |
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.
Topics: Animals; Anticonvulsants; Antitubercular Agents; Autophagy; Carbamazepine; Cell Line; Disease Models | 2015 |
Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carbamazepine; Cardiovirus Infections; Comorbid | 2015 |
New benzo[d]thiazol-2-yl-aminoacetamides as potential anticonvulsants: synthesis, activity and prediction of molecular properties.
Topics: Acetamides; Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Computer Simulation; Disease Mo | 2015 |
Ellagic acid enhances the antinociceptive action of carbamazepine in the acetic acid writhing test with mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carbamazepine; Disease | 2016 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Pathogenetic analyses of carbamazepine-induced liver injury in F344 rats focused on immune- and inflammation-related factors.
Topics: Animals; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2016 |
Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2016 |
Effects of carbamazepine on cortisol levels and behavioral responses to stress in the fish Jenynsia multidentata.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Disease Models, A | 2016 |
Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Co | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; C | 2016 |
Comparison of different osmotic therapies in a mouse model of traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Carbamazepine; Disease Models, Animal; Male; Maze Learning; Mice | 2017 |
Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbamazepine; Cyanobacteria; Dip | 2017 |
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Carbamazepine; Cells, Cultured; Disease Models, Ani | 2017 |
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Autophagy; Carbamazepine; Disease Models, Animal; Hippocampus; Male; Maz | 2017 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Di | 2009 |
Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine.
Topics: 4-Aminopyridine; Acoustic Stimulation; Animals; Anticonvulsants; Auditory Threshold; Carbamazepine; | 2008 |
Effects of carbamazepine on spinal cord ischemia.
Topics: Animals; Biopsy, Needle; Carbamazepine; Disease Models, Animal; Female; Immunohistochemistry; Male; | 2008 |
Synthesis of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzoxazoles; Carbamazepine; Disease Models, Animal; Ele | 2009 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Dis | 2010 |
Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri.
Topics: Animals; Anticonvulsants; Bacopa; Carbamazepine; Disease Models, Animal; Epilepsy; Ergolines; Hippoc | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Role of ventral hippocampal GABA(A) and NMDA receptors in the anxiolytic effect of carbamazepine in rats using the elevated plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbamazepine; Disease Models, Animal; GABA Agonists; GABA An | 2009 |
Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Dopamine Antago | 2010 |
Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.
Topics: Animals; Anticonvulsants; Behavioral Symptoms; Bicuculline; Carbamazepine; Cerebellum; Disease Model | 2010 |
Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; ga | 2010 |
Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A.
Topics: Animals; Anticonvulsants; Bacopa; Basal Ganglia; Behavior, Animal; Bicuculline; Binding, Competitive | 2010 |
Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Biological Availability; Carbamazepine; Catalase; C | 2010 |
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Autophagy; Carbamazepine; Cell Line; D | 2010 |
Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression.
Topics: Absorption; Animals; Anticonvulsants; Aquaporin 2; Carbamazepine; Diabetes Insipidus; Disease Models | 2010 |
Influence of carbamazepine on kindling grades in depressive and non-depressive rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Depression; Disease Models, Animal; Electric Stimulation; E | 2010 |
Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2010 |
Pharmacological interaction between oxcarbazepine and two COX inhibitors in a rat model of inflammatory hyperalgesia.
Topics: Animals; Carbamazepine; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Interactions; Hype | 2011 |
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Catalase; Cognition Disorders; Disease Models, Animal; Drug | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine.
Topics: Acoustic Stimulation; Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Carbamazepine; C | 2011 |
Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dopamine; Hippocampus; Homovanillic | 2011 |
Sulfobutyl ether(7) β-cyclodextrin (SBE(7) β-CD) carbamazepine complex: preparation, characterization, molecular modeling, and evaluation of in vivo anti-epileptic activity.
Topics: Administration, Oral; Animals; Anticonvulsants; beta-Cyclodextrins; Calorimetry, Differential Scanni | 2011 |
The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Carbamazepine; Disease Models, Animal; Drug Interacti | 2012 |
A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2012 |
Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase.
Topics: Analgesics, Non-Narcotic; Animals; Arabidopsis Proteins; Area Under Curve; Carbamazepine; Chromatogr | 2012 |
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultu | 2012 |
Chronic application of topiramate and carbamazepine differentially affects the EEG and penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroencephalography; Epil | 2012 |
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Constitutive Androstane Rece | 2012 |
A rat model for LGI1-related epilepsies.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus ae | 2012 |
Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury.
Topics: Alanine Transaminase; Alprostadil; Animals; Anticonvulsants; Aspartate Aminotransferases; Biomarkers | 2012 |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy.
Topics: Alleles; Angiotensin-Converting Enzyme Inhibitors; Animals; Anterior Temporal Lobectomy; Anticonvuls | 2012 |
Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2012 |
The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroence | 2012 |
Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2013 |
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice.
Topics: Animals; Autophagy; Biomarkers; Carbamazepine; Cells, Cultured; Chloroquine; Dietary Fats; Disease M | 2013 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Combination of carbamazepine and valproate in different dose proportions in maximal electroshock seizure model in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2002 |
A novel mechanism underlying drug resistance in chronic epilepsy.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Disease Models, Animal; Drug Resist | 2003 |
Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats.
Topics: Acute Disease; Analgesics; Animals; Carbamazepine; Chronic Disease; Constriction, Pathologic; Diabet | 2003 |
Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics--a comparative study.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2003 |
Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3).
Topics: alpha-Linolenic Acid; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Disease Models, | 2004 |
Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region.
Topics: 4-Aminopyridine; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2003 |
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis | 2004 |
The influence of gender on the aggravation of absence seizures by carbamazepine in the low-dose pentylenetetrazol rat model.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2004 |
Preclinical profile of combinations of some second-generation antiepileptic drugs: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2004 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Influence of ethanol on the threshold for electroshock-induced seizures and electrically-evoked hippocampal afterdischarges.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Synergism; Electric Stimulatio | 2005 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
A comprehensive electrographic and behavioral analysis of generalized tonic-clonic seizures of GEPR-9s.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Brain Mapping; Carbamazepine; Dise | 2005 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions | 2005 |
Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, | 2005 |
The effect of carbamazepine on injury-induced ectopic discharge in the lingual nerve.
Topics: Action Potentials; Animals; Anticonvulsants; Axons; Carbamazepine; Cranial Nerve Injuries; Disease M | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Dose-Respo | 2006 |
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbamazep | 2006 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response | 2006 |
The effects of alpha2-adrenoceptor agents on anti-hyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narco | 2006 |
The influence of experimental spinal cord injury on carbamazepine pharmacokinetics.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Carbamazepine; Chromatography, High Pressur | 2006 |
Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Carbamazepine; Cell Differentiat | 2006 |
Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat.
Topics: Animals; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Convulsants; Disease Models, Animal; | 2006 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; | 2007 |
Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Disease Models, Animal; Drug Interactions; Electro | 2007 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine.
Topics: Animals; Anticonvulsants; Antigens, CD; Axons; Carbamazepine; Cell Count; Disease Models, Animal; En | 2007 |
Effect of oxcarbazepine pretreatment on convulsive activity and brain damage induced by kainic acid administration in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Epilepsy; | 2008 |
Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
Topics: Administration, Oral; Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, A | 2007 |
The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Carbamazepine; Clonidine; Disease Models, Animal; Dos | 2007 |
Role of alpha2-adrenoceptors in the local peripheral antinociception by carbamazepine in a rat model of inflammatory mechanical hyperalgesia.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Ani | 2007 |
Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2008 |
Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors?
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Antidepressive Agents; Carbamazepine; Depression | 2008 |
Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Carbamazepine; Corpus Luteum; Disease Models, Animal; Dose-Resp | 2008 |
GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia.
Topics: Analgesics, Non-Narcotic; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Concanavalin A; Dise | 2008 |
The antinociceptive effects of anticonvulsants in a mouse visceral pain model.
Topics: Acetic Acid; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Cyclohex | 2008 |
Drug effects on afterdischarge and seizure threshold in lissencephalic ferrets: an epilepsy model for drug evaluation.
Topics: Animals; Carbamazepine; Disease Models, Animal; Drug Evaluation; Epilepsy; Female; Ferrets; Male; Th | 1983 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
[Pathogenesis of secondary contractures of the mimetic muscles].
Topics: Animals; Carbamazepine; Contracture; Disease Models, Animal; Facial Muscles; Facial Nerve; Geniculat | 1980 |
Prevention of neuronal cell death by anticonvulsants in experimental epilepsy (extended abstract).
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Cell Survival; Disease Models, Animal; gam | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; | 1995 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge | 1993 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Anim | 1993 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Cycloserine; Disease | 1996 |
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamazepine; Dioxolanes; Disease Mod | 1996 |
Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Carbamazepine; Cyclodextrins; Diseas | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1997 |
Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity.
Topics: Animals; Carbamazepine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Disease Models, | 1997 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models, | 1997 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1998 |
The effect of oxcarbazepine on behavioural despair and learned helplessness.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Depression; Disease Models, Animal; Helpl | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 1998 |
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anti | 1998 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine.
Topics: Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleat | 2000 |
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 2000 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2000 |
The antidepressive-like effect of oxcarbazepine: possible role of dopaminergic neurotransmission.
Topics: Animals; Antidepressive Agents; Apomorphine; Carbamazepine; Catalepsy; Disease Models, Animal; Dopam | 2000 |
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, An | 2000 |
Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzofurans; Ca | 2000 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute carbamazepine.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2001 |
Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder.
Topics: Administration, Oral; Animals; Anticonvulsants; Bipolar Disorder; Brain; Carbamazepine; Disease Mode | 2002 |
Carbamazepine revisited in a monkey model.
Topics: Animals; Biological Availability; Carbamazepine; Disease Models, Animal; Electroencephalography; Hap | 1979 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Acute anticonvulsant effects of diphenylhydantoin, phenobarbital, and carbamazepine: a combined electroclinical and serum level study in amygdaloid kindled cats and baboons.
Topics: Amygdala; Animals; Carbamazepine; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1976 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Reduction of frequency of seizures by carbamazepine during cobalt experimental epilepsy in the rat.
Topics: Animals; Carbamazepine; Cobalt; Disease Models, Animal; Epilepsy; Female; Rats; Rats, Inbred Strains | 1992 |
Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine.
Topics: Alprazolam; Animals; Anxiety; Carbamazepine; Cerebral Cortex; Disease Models, Animal; Drug Administr | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Effects of acute or chronic carbamazepine on experimentally-induced conflict in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Conditioning, Operant; Conflict, Psychological; D | 1990 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
The effects of carbamazepine on two animal models of depression.
Topics: Animals; Carbamazepine; Depressive Disorder; Disease Models, Animal; Haloperidol; Imipramine; Male; | 1987 |
Temporal lobe and petit mal antiepileptics differentially affect ventral lateral thalamic and motor cortex excitability patterns.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Epilepsy, Absence; Ethosuximide; Evoked Potent | 1988 |
Differences in antiepileptic drug efficacy in hippocampally kindled normal and microcephalic rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Elect | 1986 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Pharmacokinetic evaluation of anticonvulsants prior to efficacy testing exemplified by carbamazepine in epileptic monkey model.
Topics: Administration, Oral; Animals; Carbamazepine; Delayed-Action Preparations; Disease Models, Animal; D | 1974 |