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carbamazepine and Developmental Disabilities

carbamazepine has been researched along with Developmental Disabilities in 20 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)

Research Excerpts

ExcerptRelevanceReference
"The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5."4.90Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014)
"The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine."3.76Growth hormone levels in children and adolescents with epilepsy. ( Al-Badani, AK; Aly, GS; El-Khayat, HA; Mamdouh, RM; Mohamed, EI; Tomoum, HY, 2010)
"Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom."3.75Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009)
"To compare pregnancy outcome prospectively after phenytoin and carbamazepine monotherapy with outcome in matched mother-child pairs exposed to nonteratogens to evaluate the relative fetal safety of these drugs."3.69Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. ( Ashby, P; Czuchta, D; Einarson, T; Gardner, HA; Gladstone, D; Gladstone, R; Nulman, I; Rovet, J; Scolnik, D; Weksberg, R, 1994)
"To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy."1.56Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020)
"For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0."1.40Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014)
"The paroxysmal dyskinesias are a heterogeneous group of movement disorders."1.35Oxcarbazepine use in paroxysmal kinesigenic dyskinesia: report on four patients. ( Chillag, KL; Deroos, ST, 2009)
"There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication."1.32A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003)
"Physicians treating epilepsy must be aware that CBZ can exacerbate seizures, and cause developmental regression in children."1.30Seizure exacerbation and developmental regression with carbamazepine. ( Nagarajan, L; Prasad, AN; Stefanelli, M, 1998)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (25.00)18.2507
2000's5 (25.00)29.6817
2010's9 (45.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Daugaard, CA1
Pedersen, L1
Sun, Y1
Dreier, JW1
Christensen, J1
Cherian, A1
Jabeen, SA1
Kandadai, RM1
Iype, T1
Moturi, P1
Reddy, M1
Kanikannan, MA1
Borgohain, R1
Padmanabhan, S1
Baek, JH1
Seo, YH1
Kim, GH1
Kim, MK1
Eun, BL1
Verrotti, A1
Scaparrotta, A1
Cofini, M1
Chiarelli, F1
Tiboni, GM1
Bromley, R1
Weston, J1
Adab, N2
Greenhalgh, J1
Sanniti, A1
McKay, AJ1
Tudur Smith, C1
Marson, AG1
Chillag, KL1
Deroos, ST1
Meador, KJ2
Baker, GA2
Browning, N1
Clayton-Smith, J3
Combs-Cantrell, DT1
Cohen, M1
Kalayjian, LA1
Kanner, A1
Liporace, JD1
Pennell, PB1
Privitera, M1
Loring, DW2
El-Khayat, HA1
Aly, GS1
Tomoum, HY1
Mamdouh, RM1
Al-Badani, AK1
Mohamed, EI1
Cummings, C1
Stewart, M1
Stevenson, M1
Morrow, J1
Nelson, J1
Blumkin, L1
Suls, A1
Deconinck, T1
De Jonghe, P1
Linder, I1
Kivity, S1
Dabby, R1
Leshinsky-Silver, E1
Lev, D1
Lerman-Sagie, T1
Verhoeven, WM1
Egger, JI1
Cohen-Snuijf, R1
Kant, SG1
de Leeuw, N1
Bromley, RL1
Mawer, GE1
Briggs, M1
Cheyne, C1
García-Fiñana, M1
Kneen, R1
Lucas, SB1
Shallcross, R1
Burton, KJ1
Allen, S1
Kini, U1
Vinten, J1
Fryer, A1
Piantino, JA1
Torres, A1
Scolnik, D1
Nulman, I1
Rovet, J1
Gladstone, D1
Czuchta, D1
Gardner, HA1
Gladstone, R1
Ashby, P1
Weksberg, R1
Einarson, T1
Jeret, JS1
Thompson, WO1
Prasad, AN1
Stefanelli, M1
Nagarajan, L1
Rosenberg, DR1
Crowner, S1
Thomas, C1
Gourash, L1

Reviews

3 reviews available for carbamazepine and Developmental Disabilities

ArticleYear
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
    Reproductive toxicology (Elmsford, N.Y.), 2014, Volume: 48

    Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili

2014
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
    The Cochrane database of systematic reviews, 2014, Oct-30, Issue:10

    Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu

2014
Psychosis and idiopathic precocious puberty in two 7-year-old boys.
    Child psychiatry and human development, 1992,Summer, Volume: 22, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Body Height; Carbamazepine; Child; Developmental Disa

1992

Other Studies

17 other studies available for carbamazepine and Developmental Disabilities

ArticleYear
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
    JAMA network open, 2020, 11-02, Volume: 3, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen

2020
Epilepsy with myoclonic absences in siblings.
    Brain & development, 2014, Volume: 36, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Electroencephalography; Epilepsie

2014
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
    Yonsei medical journal, 2014, Volume: 55, Issue:2

    Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr

2014
Oxcarbazepine use in paroxysmal kinesigenic dyskinesia: report on four patients.
    Pediatric neurology, 2009, Volume: 40, Issue:4

    Topics: Adolescent; Age of Onset; Anti-Dyskinesia Agents; Carbamazepine; Child; Developmental Disabilities;

2009
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
    The New England journal of medicine, 2009, Apr-16, Volume: 360, Issue:16

    Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose

2009
Growth hormone levels in children and adolescents with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:6

    Topics: Adolescent; Anthropometry; Body Weight; Carbamazepine; Chi-Square Distribution; Child; Developmental

2010
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
    Archives of disease in childhood, 2011, Volume: 96, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities;

2011
Neonatal seizures associated with a severe neonatal myoclonus like dyskinesia due to a familial KCNQ2 gene mutation.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Developmental Disabilities; Dyskinesias; Electroencephalograp

2012
Phelan-McDermid syndrome: clinical report of a 70-year-old woman.
    American journal of medical genetics. Part A, 2013, Volume: 161A, Issue:1

    Topics: Aged; Butyrophenones; Carbamazepine; Carrier Proteins; Choline Kinase; Chromosome Deletion; Chromoso

2013
The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.
    Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child Development Disorders, Per

2013
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
    Annals of tropical paediatrics, 2003, Volume: 23, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem

2003
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
    Archives of disease in childhood. Fetal and neonatal edition, 2006, Volume: 91, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child

2006
Myoclonic seizures in a patient with Charcot-Marie-tooth disease.
    Pediatric neurology, 2007, Volume: 36, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Charcot-Marie-Tooth Disease; Child; Developmental Disabilities; Drug

2007
Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy.
    JAMA, 1994, Mar-09, Volume: 271, Issue:10

    Topics: Carbamazepine; Case-Control Studies; Child; Cognition; Developmental Disabilities; Female; Humans; I

1994
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
    JAMA, 1994, Sep-21, Volume: 272, Issue:11

    Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp

1994
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
    JAMA, 1994, Sep-21, Volume: 272, Issue:11

    Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp

1994
Seizure exacerbation and developmental regression with carbamazepine.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1998, Volume: 25, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Devel

1998