carbamazepine has been researched along with Depressive Disorder, Major in 22 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study has shown the beneficial effects of the herbal medicine called Free and Easy Wanderer Plus (FEWP) as adjunctive therapy with carbamazepine (CBZ) in the 12-week treatment of bipolar disorders (Zhang ZJ, Kang WH, Tan QR, Li Q, Gao CG, Zhang FG, et al." | 5.12 | The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) for mood disorders: double-blind, placebo-controlled studies. ( Kang, WH; Li, Q; Tan, QR; Zhang, ZJ, 2007) |
| " 2) Four groups (T1-T4) of remitted patients with bipolar disorders (20 in each group) were successfully maintained on mood stabilizers (lithium or carbamazepine) and classified by the duration of their episode-free period." | 5.10 | The influence of successful prophylactic drug treatment on cognitive dysfunction in bipolar disorders. ( Müller-Oerlinghausen, B; Wolf, T, 2002) |
| " Part 1 was an open-label pharmacokinetic assessment of a single 5-mg vilazodone dose with or without ketoconazole." | 2.79 | Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects. ( Boinpally, R; Gad, N; Gupta, S; Periclou, A, 2014) |
| "Although mania defines bipolar I disorder, depressive episodes and symptoms dominate the longitudinal course of, and disproportionately account for morbidity and mortality in, bipolar disorders." | 2.66 | Bipolar disorders. ( Berk, M; Brietzke, E; Goldstein, BI; Kessing, LV; López-Jaramillo, C; Majeed, A; Malhi, GS; Mansur, RB; McIntyre, RS; Nierenberg, AA; Rosenblat, JD; Vieta, E; Vinberg, M; Young, AH, 2020) |
| " This study was designed to evaluate the bidirectional carbamazepine-armodafinil pharmacokinetic drug-drug interaction." | 1.42 | Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults. ( Bond, M; Darwish, M; Hellriegel, ET; Robertson, P; Yang, R, 2015) |
| " LGI1 gene dosage was performed by real-time quantitative PCR (qPCR)." | 1.38 | LGI1 microdeletion in autosomal dominant lateral temporal epilepsy. ( Barozzi, C; Cubeddu, T; de Falco, A; de Falco, FA; Errichiello, L; Fanciulli, M; Michelucci, R; Nobile, C; Rampazzo, A; Rigon, L; Santulli, L; Striano, P; Striano, S; Tomasi, L; Uzzau, S, 2012) |
| "Citalopram is a chiral antidepressant drug." | 1.31 | Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study. ( Baumann, P; Brawand-Amey, M; Eap, CB; Steinacher, L; Vandel, P; Zullino, DF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 14 (63.64) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| McIntyre, RS | 1 |
| Berk, M | 1 |
| Brietzke, E | 1 |
| Goldstein, BI | 1 |
| López-Jaramillo, C | 1 |
| Kessing, LV | 1 |
| Malhi, GS | 1 |
| Nierenberg, AA | 1 |
| Rosenblat, JD | 1 |
| Majeed, A | 1 |
| Vieta, E | 1 |
| Vinberg, M | 1 |
| Young, AH | 1 |
| Mansur, RB | 1 |
| Boinpally, R | 1 |
| Gad, N | 1 |
| Gupta, S | 1 |
| Periclou, A | 1 |
| Darwish, M | 1 |
| Bond, M | 1 |
| Yang, R | 1 |
| Hellriegel, ET | 1 |
| Robertson, P | 1 |
| Bauer, M | 1 |
| Severus, E | 1 |
| Köhler, S | 1 |
| Whybrow, PC | 1 |
| Angst, J | 1 |
| Möller, HJ | 1 |
| Schüle, C | 1 |
| Baghai, TC | 1 |
| Eser, D | 1 |
| Nothdurfter, C | 1 |
| Rupprecht, R | 1 |
| Preskorn, SH | 1 |
| Vigo, DV | 1 |
| Baldessarini, RJ | 1 |
| Aggarwal, A | 1 |
| Jain, M | 1 |
| Garg, A | 1 |
| Jiloha, RC | 1 |
| Sánchez-Romero, A | 1 |
| Mayordomo-Aranda, A | 1 |
| García-Delgado, R | 1 |
| Durán-Quintana, JA | 1 |
| Smith, AK | 1 |
| Conneely, KN | 1 |
| Newport, DJ | 1 |
| Kilaru, V | 1 |
| Schroeder, JW | 1 |
| Pennell, PB | 1 |
| Knight, BT | 1 |
| Cubells, JC | 1 |
| Stowe, ZN | 1 |
| Brennan, PA | 1 |
| Fanciulli, M | 1 |
| Santulli, L | 1 |
| Errichiello, L | 1 |
| Barozzi, C | 1 |
| Tomasi, L | 1 |
| Rigon, L | 1 |
| Cubeddu, T | 1 |
| de Falco, A | 1 |
| Rampazzo, A | 1 |
| Michelucci, R | 1 |
| Uzzau, S | 1 |
| Striano, S | 1 |
| de Falco, FA | 1 |
| Striano, P | 1 |
| Nobile, C | 1 |
| Wolf, T | 1 |
| Müller-Oerlinghausen, B | 1 |
| Chidori, S | 1 |
| Nishimura, R | 1 |
| Ros, LT | 1 |
| Hantouche, EG | 1 |
| Akiskal, HS | 1 |
| Lancrenon, S | 1 |
| Chatenêt-Duchêne, L | 1 |
| Beitinger, PA | 1 |
| Kirmeier, T | 1 |
| Bronisch, T | 1 |
| Wetter, TC | 1 |
| Zhang, ZJ | 1 |
| Kang, WH | 1 |
| Li, Q | 1 |
| Tan, QR | 1 |
| Lutz, UC | 1 |
| Wiatr, G | 1 |
| Gaertner, HJ | 1 |
| Bartels, M | 1 |
| Ketter, TA | 2 |
| Kimbrell, TA | 2 |
| George, MS | 1 |
| Willis, MW | 1 |
| Benson, BE | 1 |
| Danielson, A | 1 |
| Frye, MA | 2 |
| Herscovitch, P | 1 |
| Post, RM | 2 |
| Perino, C | 1 |
| Rago, R | 1 |
| Cicolini, A | 1 |
| Torta, R | 1 |
| Monaco, F | 1 |
| Osuch, EA | 1 |
| Cora-Locatelli, G | 1 |
| Huggins, T | 1 |
| Callahan, AM | 1 |
| Steinacher, L | 1 |
| Vandel, P | 1 |
| Zullino, DF | 1 |
| Eap, CB | 1 |
| Brawand-Amey, M | 1 |
| Baumann, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for carbamazepine and Depressive Disorder, Major
| Article | Year |
|---|---|
Bipolar disorders.
Topics: Adolescent; Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; B | 2020 |
Anticonvulsants in the treatment of major depressive disorder: an overview.
Topics: Anticonvulsants; Antidepressive Agents; Carbamazepine; Clinical Trials as Topic; Depressive Disorder | 2009 |
[Mood disorder in childhood and adolescence].
Topics: Bipolar Disorder; Carbamazepine; Depressive Disorder, Major; Diagnostic and Statistical Manual of Me | 2003 |
5 trials available for carbamazepine and Depressive Disorder, Major
| Article | Year |
|---|---|
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.
Topics: Adolescent; Adult; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; Cytochrome P- | 2014 |
Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study.
Topics: Adult; Aged; Anticonvulsants; Antidepressive Agents, Tricyclic; Antimanic Agents; Biological Availab | 2009 |
The influence of successful prophylactic drug treatment on cognitive dysfunction in bipolar disorders.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Cognition Disorders; Depressive Disord | 2002 |
The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) for mood disorders: double-blind, placebo-controlled studies.
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Depressive Disorder, Majo | 2007 |
Post-dexamethasone cortisol correlates with severity of depression before and during carbamazepine treatment in women but not men.
Topics: Adult; Bipolar Disorder; Carbamazepine; Depressive Disorder, Major; Dexamethasone; Female; Humans; H | 2001 |
14 other studies available for carbamazepine and Depressive Disorder, Major
| Article | Year |
|---|---|
Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults.
Topics: Adult; Anticonvulsants; Benzhydryl Compounds; Bipolar Disorder; Carbamazepine; Cytochrome P-450 CYP3 | 2015 |
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders. part 2: maintenance treatment of major depressive disorder-update 2015.
Topics: Antidepressive Agents; Antipsychotic Agents; Biological Psychiatry; Carbamazepine; Depressive Disord | 2015 |
Practical application of therapeutic drug monitoring: a tale of two patients.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Dr | 2008 |
Carbamazepine for serotonin reuptake inhibitor nonresponder case of obsessive compulsive disorder.
Topics: Adult; Anticonvulsants; Carbamazepine; Citalopram; Depressive Disorder, Major; Humans; Male; Obsessi | 2009 |
Probable interaction between trazodone and carbamazepine.
Topics: Aged; Anticonvulsants; Antidepressive Agents, Second-Generation; Antimanic Agents; Carbamazepine; De | 2011 |
Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.
Topics: Anticonvulsants; Carbamazepine; CpG Islands; Depressive Disorder, Major; DNA Methylation; Drug Evalu | 2012 |
LGI1 microdeletion in autosomal dominant lateral temporal epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety; Carbamazepine; Depressive Disorder, Major; Electroencep | 2012 |
A case of "double" depression under outpatient treatment conditions.
Topics: Adult; Ambulatory Care; Anticonvulsants; Carbamazepine; Clonazepam; Depressive Disorder, Major; Diag | 2004 |
Mood stabilizer augmentation in apparently "unipolar" MDD: predictors of response in the naturalistic French national EPIDEP study.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Carbamazepine; De | 2005 |
Association of auditory hallucinations and anticonvulsant hypersensitivity syndrome with carbamazepine treatment. A case report.
Topics: Anticonvulsants; Carbamazepine; Depressive Disorder, Major; Drug Hypersensitivity; Hallucinations; H | 2006 |
Oxcarbazepine treatment during breast-feeding: a case report.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Child, Preschool; Depressiv | 2007 |
Baseline cerebral hypermetabolism associated with carbamazepine response, and hypometabolism with nimodipine response in mood disorders.
Topics: Adult; Antimanic Agents; Calcium Channel Blockers; Carbamazepine; Cerebral Cortex; Depressive Disord | 1999 |
Mood and behavioural disorders following traumatic brain injury: clinical evaluation and pharmacological management.
Topics: Adult; Antidepressive Agents; Brain Injuries; Brief Psychiatric Rating Scale; Carbamazepine; Citalop | 2001 |
Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Antimanic Agents; Carbamazepi | 2002 |