carbamazepine has been researched along with Complications, Pregnancy in 178 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 8.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| " In this review, the safety of the newer AED oxcarbazepine during pregnancy is assessed based on published pregnancy outcome data." | 8.82 | Safety of the newer antiepileptic drug oxcarbazepine during pregnancy. ( Montouris, G, 2005) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "To check for an association between carbamazepine (CBZ) use by the mother during pregnancy and congenital eye malformations (i." | 8.81 | Is there an association between maternal carbamazepine use during pregnancy and eye malformations in the child? ( Cornel, MC; Kroes, HY; Reefhuis, J, 2002) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 7.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "The aims of this study were to characterize the alterations in total and free carbamazepine (CBZ) and in total and free carbamazepine-epoxide (CBZ-EPO) clearances during pregnancy, to calculate the change in free fractions of CBZ and CBZ-EPO during pregnancy, and to determine whether seizure worsening is associated with a low ratio to nonpregnant baseline concentration of total or free CBZ or CBZ-EPO." | 7.80 | Carbamazepine clearance and seizure stability during pregnancy. ( Johnson, EL; Knight, B; Newman, ML; Newport, DJ; Pennell, PB; Ritchie, JC; Stowe, ZN, 2014) |
| "Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other malformations." | 7.78 | Is carbamazepine safe to take during pregnancy? ( Koren, G; Matlow, J, 2012) |
| "Thirteen pregnancies in ten women on oxcarbazepine (OXC) monotherapy and one pregnancy in a woman on OXC and topiramate therapy were retrospectively analyzed." | 7.75 | Seizure deterioration in women treated with oxcarbazepine during pregnancy. ( Hansen-Schwartz, J; Petrenaite, V; Sabers, A, 2009) |
| "We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy." | 7.73 | Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy. ( Christensen, J; Sabers, A; Sidenius, P, 2006) |
| " Preceding a planned pregnancy, the patient was switched to oxcarbazepine and tapered off both phenytoin and gabapentin." | 7.73 | Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006) |
| "To determine potential changes in the plasma concentrations of oxcarbazepine (OXC) and its metabolites during pregnancy and puerperium." | 7.73 | Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium. ( Atakli, D; Gatti, G; Mazzucchelli, I; Neve, AL; Onat, FY; Ozkara, C; Perucca, E; Specchio, LM, 2006) |
| "To report a case of transient cholestatic hepatitis occurring in an infant between the third and seventh weeks of life, most likely due to carbamazepine exposure during pregnancy and breast feeding." | 7.71 | Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breast feeding. ( Braegger, CP; Frey, B; Ghelfi, D, 2002) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 7.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "The purpose of the study was to assess whether there was an increased rate of congenital anomalies or significant developmental delay in infants of women with epilepsy who had been treated with carbamazepine during pregnancy." | 7.69 | Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. ( Cohen, E; Ornoy, A, 1996) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 7.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| "We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding." | 7.68 | Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. ( Frey, B; Musy, JP; Schubiger, G, 1990) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 7.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| " In case of breakthrough seizures or increased seizure frequency, dosage adjustment of both drugs may be required." | 5.36 | Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy. ( de Haan, GJ; Edelbroek, P; Lindhout, D; Sander, JW; Wegner, I, 2010) |
| "Pregnant women with epilepsy on one or more of the following AEDs: lamotrigine, carbamazepine, phenytoin or levetiracetam." | 5.27 | AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. ( Bagary, M; Coleman, J; D'Amico, M; Denny, E; Dodds, J; Eldridge, S; Greenhill, L; Hard, K; Kelso, A; Khan, KS; Marlin, N; McCorry, D; Middleton, L; Moss, N; Newton, S; Pirie, A; Pullen, A; Rikunenko, R; Roberts, T; Rogozińska, E; Thangaratinam, S; Weckesser, A, 2018) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 4.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| " Oxcarbazepine and lamotrigine were associated with increased occurrence of autism." | 4.95 | Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. ( Cogo, E; D'Souza, J; Finkelstein, Y; Hemmelgarn, BR; Hutton, B; Kealey, R; MacDonald, H; Reynen, E; Rios, P; Soobiah, C; Straus, SE; Thavorn, K; Tricco, AC; Veroniki, AA; Yazdi, F, 2017) |
| "The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5." | 4.90 | Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014) |
| "A systematic search was carried out of electronic databases, reference books and other sources for original research studies which examined the effects of commonly used mood stabilizers (sodium valproate, carbamazepine, lamotrigine and lithium carbonate) on pregnancy outcomes." | 4.86 | Mood stabilizers in pregnancy: a systematic review. ( Buist, A; Galbally, M; Roberts, M, 2010) |
| "To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy." | 4.86 | Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. ( de Jong-van den Berg, L; Dolk, H; Garne, E; Jentink, J; Loane, MA; Morris, JK; Wellesley, D, 2010) |
| " In this review, the safety of the newer AED oxcarbazepine during pregnancy is assessed based on published pregnancy outcome data." | 4.82 | Safety of the newer antiepileptic drug oxcarbazepine during pregnancy. ( Montouris, G, 2005) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "To check for an association between carbamazepine (CBZ) use by the mother during pregnancy and congenital eye malformations (i." | 4.81 | Is there an association between maternal carbamazepine use during pregnancy and eye malformations in the child? ( Cornel, MC; Kroes, HY; Reefhuis, J, 2002) |
| " The terms used individually and in combination were oxcarbazepine, carbamazepine, epilepsy, and seizures." | 4.81 | Oxcarbazepine, an antiepileptic agent. ( Huff, NA; Kalis, MM, 2001) |
| "05) of an increased hazard of fetal malformation associated with exposure to valproate, carbamazepine, topiramate, zonisamide, and with conception after assisted fertilization, but a reduced hazard in the offspring of women who continued to smoke during pregnancy." | 4.31 | Specific fetal malformations following intrauterine exposure to antiseizure medication. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 3.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "Carbamazepine and topiramate both have established potentials for causing teratogenesis, and it is possible that replacement of carbamazepine with a less teratogenic AED, for example levetiracetam, might result in any subsequent depression that occurs in pregnancy being inappropriately attributed to the newly introduced agent." | 3.96 | Antiepileptic drugs and depression during pregnancy in women with epilepsy. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Horgan, D; Lander, CM; Mitchell, J; O'Brien, TJ; Vajda, FJE, 2020) |
| "Intrauterine exposure to anti-epileptic drugs, particularly carbamazepine, may be associated with an increased risk of foetal death during pregnancy." | 3.88 | Anti-epileptic drug exposure and risk of foetal death in utero. ( Eadie, MJ; Graham, J; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2018) |
| " This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age." | 3.88 | Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. ( Baldessarini, RJ; Patel, N; Viguera, AC, 2018) |
| "Carbamazepine is one of the three most frequently prescribed antiepileptic drugs in pregnancy." | 3.83 | Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2016) |
| "Maternal epilepsy treated with carbamazepine and migraine were found to be associated with higher risk of ventricular septal defect; panic disorders were associated with higher risk of hypoplastic left heart; type I diabetes mellitus was associated with higher risk of coarctation of the aorta; chronic hypertension was associated with higher risk of ventricular septal defect, common atrioventricular canal and common truncus; and paroxysmal supraventricular tachycardia was associated with higher risk of atrial septal defect secundum, common atrioventricular canal and ventricular septal defect." | 3.80 | Association of certain chronic maternal diseases with the risk of specific congenital heart defects: a population-based study. ( Czeizel, AE; Gerencsér, B; Szabó, I; Vereczkey, A, 2014) |
| "The aims of this study were to characterize the alterations in total and free carbamazepine (CBZ) and in total and free carbamazepine-epoxide (CBZ-EPO) clearances during pregnancy, to calculate the change in free fractions of CBZ and CBZ-EPO during pregnancy, and to determine whether seizure worsening is associated with a low ratio to nonpregnant baseline concentration of total or free CBZ or CBZ-EPO." | 3.80 | Carbamazepine clearance and seizure stability during pregnancy. ( Johnson, EL; Knight, B; Newman, ML; Newport, DJ; Pennell, PB; Ritchie, JC; Stowe, ZN, 2014) |
| "To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with carbamazepine, lamotrigine, phenobarbital, or valproate." | 3.79 | Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F, 2013) |
| "Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other malformations." | 3.78 | Is carbamazepine safe to take during pregnancy? ( Koren, G; Matlow, J, 2012) |
| "Based on epidemiological data it is advised to whenever possible avoid valproic acid during pregnancy." | 3.78 | Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. ( Boersma, C; de Jong-van den Berg, LT; Jentink, J; Postma, MJ, 2012) |
| "To determine the frequency of malformations among infants born to women who had taken lamotrigine or carbamazepine as part of polytherapy during the first trimester of pregnancy." | 3.77 | Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations. ( Hernandez-Diaz, S; Holmes, LB; Mittendorf, R; Shen, A; Smith, CR, 2011) |
| " To assess the impact of influencing AED prescribing practices on spina bifida and cleft palate we searched the literature for estimates of the association between valproic acid or carbamazepine use during pregnancy and these defects and summarized the associations using meta-analyses." | 3.77 | Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. ( Boulet, SL; Broussard, CS; Devine, OJ; Duwe, KN; Flak, AL; Gilboa, SM; Honein, MA; Moore, CA; Werler, MM, 2011) |
| "Valproic acid, which current guidelines suggest should be avoided in pregnancy, was most notable in terms of strength and breadth of its associations." | 3.77 | Use of antiepileptic medications in pregnancy in relation to risks of birth defects. ( Ahrens, KA; Anderka, MT; Bosco, JL; Gilboa, SM; Holmes, LB; Mitchell, AA; Werler, MM, 2011) |
| " The carbamazepine concentration in breast milk of one epilepsy maternal patient was assayed by high performance liquid chromatography, and the literature was reviewed to find the nursing evidence in the use of cabamazepine." | 3.76 | [A case report of monitoring on carbamazepine in breast feeding woman]. ( Wei, Y; Xiong, X; Yang, L; Zhai, SD; Zhao, M; Zhou, Y, 2010) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| "Thirteen pregnancies in ten women on oxcarbazepine (OXC) monotherapy and one pregnancy in a woman on OXC and topiramate therapy were retrospectively analyzed." | 3.75 | Seizure deterioration in women treated with oxcarbazepine during pregnancy. ( Hansen-Schwartz, J; Petrenaite, V; Sabers, A, 2009) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| " By contrast, offspring of rats exposed to carbamazepine (which at the dose used produced low plasma concentrations) or to generalized convulsive seizures showed no clear-cut evidence of dysplasias." | 3.74 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| " Preceding a planned pregnancy, the patient was switched to oxcarbazepine and tapered off both phenytoin and gabapentin." | 3.73 | Treatment with oxcarbazepine during pregnancy. ( Eisenschenk, S, 2006) |
| "To determine potential changes in the plasma concentrations of oxcarbazepine (OXC) and its metabolites during pregnancy and puerperium." | 3.73 | Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium. ( Atakli, D; Gatti, G; Mazzucchelli, I; Neve, AL; Onat, FY; Ozkara, C; Perucca, E; Specchio, LM, 2006) |
| "We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy." | 3.73 | Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy. ( Christensen, J; Sabers, A; Sidenius, P, 2006) |
| "To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy." | 3.72 | Normal intelligence in children with prenatal exposure to carbamazepine. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V; Isoaho, M; Kaaja, E; Kantola-Sorsa, E; Kotila, M; Matila, R; Nylund, T, 2004) |
| "The purpose of this study was to determine if there are any correlations between carbamazepine serum levels of epileptic mothers during pregnancy and the brainstem auditory evoked potentials in their infants as an index of drug neurotoxicity in newborns exposed prenatally." | 3.71 | Effects of prenatal exposure to carbamazepine on brainstem auditory evoked potentials in infants of epileptic mothers. ( Belmont, A; Garza, S; Ibarra, J; López, V; Poblano, A; Rosas, Y; Sosa, J, 2002) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 3.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "To report a case of transient cholestatic hepatitis occurring in an infant between the third and seventh weeks of life, most likely due to carbamazepine exposure during pregnancy and breast feeding." | 3.71 | Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breast feeding. ( Braegger, CP; Frey, B; Ghelfi, D, 2002) |
| "Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine." | 3.70 | Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000) |
| "5 months of pregnancy then carbamazepine 400 mg LP x 2/day, raised to 600 mg LP x 2/day at the 25th week of gestation because of epileptic crisis." | 3.69 | [Carbamazepine and vigabatrin in epileptic pregnant woman and side effects in the newborn infant]. ( Aboulghit, H; Beust, M; Kayemba Kay'S, S; Mourtada, A; Voisin, M, 1997) |
| "The purpose of the study was to assess whether there was an increased rate of congenital anomalies or significant developmental delay in infants of women with epilepsy who had been treated with carbamazepine during pregnancy." | 3.69 | Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. ( Cohen, E; Ornoy, A, 1996) |
| "To compare pregnancy outcome prospectively after phenytoin and carbamazepine monotherapy with outcome in matched mother-child pairs exposed to nonteratogens to evaluate the relative fetal safety of these drugs." | 3.69 | Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. ( Ashby, P; Czuchta, D; Einarson, T; Gardner, HA; Gladstone, D; Gladstone, R; Nulman, I; Rovet, J; Scolnik, D; Weksberg, R, 1994) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 3.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| " The mother had taken clonazepam, a benzodiazepine, and carbamazepine during the entire pregnancy for epilepsy." | 3.69 | Paralytic ileus in a fetus-neonate after maternal intake of benzodiazepine. ( Haeusler, MC; Hoellwarth, ME; Holzer, P, 1995) |
| "We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding." | 3.68 | Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. ( Frey, B; Musy, JP; Schubiger, G, 1990) |
| "A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy." | 3.68 | Teratogenic effect of carbamazepine. ( Vestermark, S; Vestermark, V, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "The first case describes a 15-year-old boy who received valproic acid and carbamazepine for partial seizures." | 3.68 | Loss of seizure control associated with generic substitution of carbamazepine. ( Arazi, R; Hale, BC; Pickering, PR; Welty, TE, 1992) |
| " The mother had received carbamazepine therapy for epilepsy." | 3.67 | Persistent right umbilical vein--case report and review of literature. ( Bell, AD; Gerlis, LM; Variend, S, 1986) |
| "Neural tube, craniofacial, and other congenital abnormalities have been described in infants born to mothers with epilepsy who were treated with valproic acid (VPA) during pregnancy." | 3.67 | Congenital abnormalities in two sibs exposed to valproic acid in utero. ( Anderson, L; Chitayat, D; Farrell, K; Hall, JG, 1988) |
| "Serum concentrations of the main vitamin D metabolites and of calcium, phosphate, and alkaline phosphatase were determined in each of the three trimesters of pregnancy and in simultaneously obtained maternal and cord blood at delivery in 22 epileptic women treated with diphenylhydantoin or carbamazepine alone or with a combination with one other drug." | 3.67 | Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood. ( Aarskog, D; Aksnes, L; Markestad, T; Strandjord, RE; Ulstein, M, 1984) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 3.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| "Pregnancy was thus associated with increased microsomal oxidations of phenytoin and carbamazepine, without proportionate increases in the subsequent hydrolysis of carbamazepine-10,11-epoxide and in the O-glucuronidations of the earlier stage metabolites." | 2.68 | Effects of pregnancy on various pathways of human antiepileptic drug metabolism. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1997) |
| "Pharmacotherapy for mood disorders during pregnancy is often complicated by pregnancy-related pharmacokinetic changes and the need for dose adjustments." | 2.50 | Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring. ( Byatt, N; Deligiannidis, KM; Freeman, MP, 2014) |
| "Neural tube defects (NTDs), including spina bifida and anencephaly, are common congenital malformations that occur when the neural tube fails to achieve proper closure during early embryogenesis." | 2.42 | Pathobiology and genetics of neural tube defects. ( Finnell, RH; Gould, A; Spiegelstein, O, 2003) |
| "Restless legs syndrome is a common complaint in pregnancy affecting up to one in every three women." | 2.38 | Restless legs syndrome in pregnancy. Case reports. ( McParland, P; Pearce, JM, 1990) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| " The mean dosage of AED for valproate was 498 mg/day and carbamazepine was 555 mg/day." | 1.39 | Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy. ( Begum, S; Sarma, SP; Thomas, SV, 2013) |
| " In case of breakthrough seizures or increased seizure frequency, dosage adjustment of both drugs may be required." | 1.36 | Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy. ( de Haan, GJ; Edelbroek, P; Lindhout, D; Sander, JW; Wegner, I, 2010) |
| " The number or dosage of AEDs were more often increased in pregnancies with seizures (OR: 3." | 1.33 | Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( , 2006) |
| "The incidence of birth defects in relation to specific AEDs was: valproate (16." | 1.32 | The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. ( Graham, J; Hitchcock, A; Lander, C; O'Brien, TJ; Vajda, FJ, 2003) |
| " However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups." | 1.32 | Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004) |
| " During this pregnancy the patient took a reduced dosage of carbamazepine." | 1.29 | Fetal malformations in an epileptic pregnant woman treated with carbamazepine. ( Caradonna, F; Caruso, G; Ceci, O; Clemente, R; Ferreri, R; Loizzi, P, 1996) |
| "Carbamazepine was the antiepileptic drug prescribed most frequently followed by valproic acid." | 1.28 | [The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy]. ( Bülau, P; Fröscher, W; Herrmann, R; Hildenbrand, G; Niesen, M; Penin, H, 1991) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice." | 1.26 | Teratogenic effects of anticonvulsants. ( Paulson, GW; Paulson, RB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (22.47) | 18.7374 |
| 1990's | 44 (24.72) | 18.2507 |
| 2000's | 45 (25.28) | 29.6817 |
| 2010's | 40 (22.47) | 24.3611 |
| 2020's | 9 (5.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bjørk, MH | 1 |
| Zoega, H | 1 |
| Leinonen, MK | 1 |
| Cohen, JM | 1 |
| Dreier, JW | 2 |
| Furu, K | 1 |
| Gilhus, NE | 1 |
| Gissler, M | 1 |
| Hálfdánarson, Ó | 1 |
| Igland, J | 1 |
| Sun, Y | 2 |
| Tomson, T | 7 |
| Alvestad, S | 1 |
| Christensen, J | 4 |
| Vajda, F | 4 |
| O'Brien, T | 1 |
| Graham, J | 4 |
| Hitchcock, A | 2 |
| Perucca, P | 1 |
| Lander, C | 2 |
| Eadie, M | 1 |
| Pekoz, MT | 1 |
| Aslan-Kara, K | 1 |
| Tekin, B | 1 |
| Gurses, C | 1 |
| Yeni, SN | 1 |
| Bozdemir, H | 1 |
| Keskin-Guler, S | 1 |
| Ataklı, D | 2 |
| Gul, G | 1 |
| Eren, F | 1 |
| Sarı, H | 1 |
| Gul, ZB | 1 |
| Ceyhan-Dirican, A | 1 |
| Genc, F | 1 |
| Bicer-Gomceli, Y | 1 |
| Ozkara, C | 2 |
| Delil, S | 1 |
| Atalar, AC | 1 |
| Bebek, N | 1 |
| Baykan, B | 1 |
| Bora, İ | 1 |
| Bican-Demir, A | 1 |
| Mısırlı, CH | 1 |
| Tutkavul, K | 1 |
| Velioglu, SK | 1 |
| Ilhan-Algin, D | 1 |
| Erdinc, O | 1 |
| Saygi, S | 1 |
| Tezer-Fılık, I | 1 |
| Apaydın-Dogan, E | 1 |
| Akyol, A | 1 |
| Kamisli, O | 1 |
| Yalcın, AD | 1 |
| Cakmak, G | 1 |
| Ersoy, A | 1 |
| Ustun-Ozek, S | 1 |
| Halac, G | 1 |
| Kutlu, G | 1 |
| Tantik-Pak, A | 1 |
| Yücel, SP | 1 |
| Keni, RR | 1 |
| Jose, M | 1 |
| A S, R | 1 |
| Baishya, J | 1 |
| Sankara Sarma, P | 1 |
| Thomas, SV | 3 |
| Söderberg Löfdal, K | 1 |
| Clark, CT | 1 |
| Daugaard, CA | 1 |
| Pedersen, L | 1 |
| Vajda, FJE | 3 |
| O'Brien, TJ | 4 |
| Graham, JE | 1 |
| Hitchcock, AA | 2 |
| Mitchell, J | 1 |
| Horgan, D | 1 |
| Lander, CM | 3 |
| Eadie, MJ | 7 |
| Kaplan, YC | 1 |
| Demir, O | 1 |
| Pariente, G | 1 |
| Leibson, T | 1 |
| Shulman, T | 1 |
| Adams-Webber, T | 1 |
| Barzilay, E | 1 |
| Nulman, I | 3 |
| Veroniki, AA | 1 |
| Rios, P | 1 |
| Cogo, E | 1 |
| Straus, SE | 1 |
| Finkelstein, Y | 1 |
| Kealey, R | 1 |
| Reynen, E | 1 |
| Soobiah, C | 1 |
| Thavorn, K | 1 |
| Hutton, B | 1 |
| Hemmelgarn, BR | 1 |
| Yazdi, F | 1 |
| D'Souza, J | 2 |
| MacDonald, H | 1 |
| Tricco, AC | 1 |
| Patel, N | 1 |
| Viguera, AC | 1 |
| Baldessarini, RJ | 1 |
| Battino, D | 4 |
| Bonizzoni, E | 2 |
| Craig, J | 2 |
| Lindhout, D | 6 |
| Perucca, E | 5 |
| Sabers, A | 4 |
| Thangaratinam, S | 1 |
| Marlin, N | 1 |
| Newton, S | 1 |
| Weckesser, A | 1 |
| Bagary, M | 1 |
| Greenhill, L | 1 |
| Rikunenko, R | 1 |
| D'Amico, M | 1 |
| Rogozińska, E | 1 |
| Kelso, A | 1 |
| Hard, K | 1 |
| Coleman, J | 1 |
| Moss, N | 1 |
| Roberts, T | 1 |
| Middleton, L | 1 |
| Dodds, J | 1 |
| Pullen, A | 1 |
| Eldridge, S | 1 |
| Pirie, A | 1 |
| Denny, E | 1 |
| McCorry, D | 1 |
| Khan, KS | 1 |
| Galappatthy, P | 1 |
| Liyanage, CK | 1 |
| Lucas, MN | 1 |
| Jayasekara, DTLM | 1 |
| Abhayaratna, SA | 1 |
| Weeraratne, C | 1 |
| De Abrew, K | 1 |
| Gunaratne, PS | 1 |
| Gamage, R | 1 |
| Wijeyaratne, CN | 1 |
| Barton, S | 1 |
| Nadebaum, C | 1 |
| Anderson, VA | 1 |
| Reutens, DC | 1 |
| Wood, AG | 1 |
| Cohen, MJ | 2 |
| Meador, KJ | 5 |
| May, R | 1 |
| Loblein, H | 1 |
| Conrad, T | 1 |
| Baker, GA | 5 |
| Bromley, RL | 2 |
| Clayton-Smith, J | 5 |
| Kalayjian, LA | 4 |
| Kanner, A | 2 |
| Liporace, JD | 3 |
| Pennell, PB | 4 |
| Privitera, M | 2 |
| Loring, DW | 4 |
| Richards, N | 1 |
| Reith, D | 1 |
| Stitely, M | 1 |
| Smith, A | 1 |
| Giménez, A | 1 |
| Pacchiarotti, I | 1 |
| Gil, J | 1 |
| Murru, A | 1 |
| Gomes, SP | 1 |
| Pinzón, JE | 1 |
| Anmella, G | 1 |
| Gómez-Ramiro, M | 1 |
| Verdolini, N | 1 |
| Valentí, M | 1 |
| Goikolea, JM | 1 |
| Vieta, E | 1 |
| Begum, S | 1 |
| Sarma, SP | 1 |
| Deligiannidis, KM | 1 |
| Byatt, N | 1 |
| Freeman, MP | 1 |
| Johnson, EL | 1 |
| Stowe, ZN | 1 |
| Ritchie, JC | 1 |
| Newport, DJ | 1 |
| Newman, ML | 1 |
| Knight, B | 1 |
| Vereczkey, A | 1 |
| Gerencsér, B | 1 |
| Czeizel, AE | 1 |
| Szabó, I | 1 |
| Bromley, R | 2 |
| Weston, J | 1 |
| Adab, N | 2 |
| Greenhalgh, J | 1 |
| Sanniti, A | 1 |
| McKay, AJ | 1 |
| Tudur Smith, C | 1 |
| Marson, AG | 1 |
| Briggs, M | 1 |
| Cheyne, CP | 1 |
| García-Fiñana, M | 1 |
| Gummery, A | 1 |
| Kneen, R | 1 |
| Mawer, G | 3 |
| Shallcross, R | 1 |
| Klein, P | 1 |
| Homberg, V | 1 |
| Kacirova, I | 1 |
| Grundmann, M | 1 |
| Brozmanova, H | 1 |
| Vanya, M | 1 |
| Devosa, I | 1 |
| Szok, D | 1 |
| Bártfai, G | 1 |
| Würtz, AM | 1 |
| Rytter, D | 1 |
| Vestergaard, CH | 1 |
| Vestergaard, M | 1 |
| Bech, BH | 1 |
| Harden, CL | 1 |
| Sethi, NK | 1 |
| Petrenaite, V | 1 |
| Hansen-Schwartz, J | 1 |
| Browning, N | 1 |
| Combs-Cantrell, DT | 1 |
| Cohen, M | 1 |
| Zhao, M | 1 |
| Yang, L | 1 |
| Wei, Y | 1 |
| Xiong, X | 1 |
| Zhou, Y | 1 |
| Zhai, SD | 1 |
| Galbally, M | 1 |
| Roberts, M | 1 |
| Buist, A | 1 |
| Jentink, J | 2 |
| Dolk, H | 1 |
| Loane, MA | 1 |
| Morris, JK | 1 |
| Wellesley, D | 1 |
| Garne, E | 1 |
| de Jong-van den Berg, L | 1 |
| Wegner, I | 1 |
| Edelbroek, P | 1 |
| de Haan, GJ | 1 |
| Sander, JW | 2 |
| Iniesta, I | 1 |
| Cummings, C | 1 |
| Stewart, M | 1 |
| Stevenson, M | 1 |
| Morrow, J | 1 |
| Nelson, J | 1 |
| Holmes, LB | 3 |
| Mittendorf, R | 1 |
| Shen, A | 1 |
| Smith, CR | 1 |
| Hernandez-Diaz, S | 1 |
| Gilboa, SM | 2 |
| Broussard, CS | 1 |
| Devine, OJ | 1 |
| Duwe, KN | 1 |
| Flak, AL | 1 |
| Boulet, SL | 1 |
| Moore, CA | 1 |
| Werler, MM | 2 |
| Honein, MA | 1 |
| Ahrens, KA | 1 |
| Bosco, JL | 1 |
| Mitchell, AA | 1 |
| Anderka, MT | 1 |
| Staikou, C | 1 |
| Mani, A | 1 |
| Petropoulos, G | 1 |
| Matlow, J | 1 |
| Koren, G | 2 |
| Boersma, C | 1 |
| de Jong-van den Berg, LT | 1 |
| Postma, MJ | 1 |
| Bravo, A | 1 |
| Hernandez, D | 1 |
| Martinez-Villarreal, L | 1 |
| Elizondo, G | 1 |
| Esmer, C | 1 |
| Poblano, A | 1 |
| Belmont, A | 1 |
| Sosa, J | 1 |
| Ibarra, J | 1 |
| Rosas, Y | 1 |
| López, V | 1 |
| Garza, S | 1 |
| Kroes, HY | 1 |
| Reefhuis, J | 1 |
| Cornel, MC | 2 |
| Wester, U | 1 |
| Brandberg, G | 1 |
| Larsson, M | 1 |
| Lönnerholm, T | 1 |
| Annerén, G | 1 |
| Yerby, MS | 7 |
| Finnell, RH | 2 |
| Gould, A | 1 |
| Spiegelstein, O | 1 |
| Vajda, FJ | 1 |
| Deering, SH | 1 |
| Thompson, K | 1 |
| Taylor, J | 1 |
| Hueppchen, N | 1 |
| Miller, M | 1 |
| Zaninelli, R | 1 |
| Gaily, E | 1 |
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| Hiilesmaa, V | 1 |
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| Kotila, M | 1 |
| Nylund, T | 1 |
| Bardy, A | 1 |
| Kaaja, E | 1 |
| Granström, ML | 2 |
| Meischenguiser, R | 2 |
| D'Giano, CH | 2 |
| Ferraro, SM | 2 |
| Wide, K | 2 |
| Winbladh, B | 2 |
| Källén, B | 3 |
| Shorvon, SD | 1 |
| Saygan-Karamursel, B | 1 |
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| Fryer, A | 1 |
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| Specchio, LM | 1 |
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| Ulstein, M | 1 |
| Strandjord, RE | 1 |
| Aksnes, L | 1 |
| Aarskog, D | 1 |
| Friis, ML | 1 |
| Hiilesmaa, VK | 1 |
| Teramo, K | 1 |
| Bardy, AH | 1 |
| Schmidt, D | 1 |
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| Domínguez Chavez, FJ | 1 |
| Núñez Gutiérrez, J | 1 |
| Murasaki, M | 1 |
| Okamoto, K | 1 |
| Takahashi, A | 1 |
| Nagai, T | 1 |
| Butler, CD | 1 |
| Kuhnz, W | 2 |
| Jäger-Roman, E | 1 |
| Rating, D | 1 |
| Deichl, A | 1 |
| Kunze, J | 1 |
| Helge, H | 1 |
| Nau, H | 3 |
| Paulson, GW | 1 |
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| Haeusler, MC | 1 |
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| Caruso, G | 1 |
| Caradonna, F | 1 |
| Clemente, R | 1 |
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| Garza-Morales, S | 2 |
| Ibarra-Puig, JM | 1 |
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| Gilda Mayén-Molina, D | 1 |
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| Vähäkangas, K | 2 |
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| Morales-Garcia, A | 1 |
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| Kayemba Kay'S, S | 1 |
| Beust, M | 1 |
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| Al Bunyan, M | 1 |
| Abo-Talib, Z | 1 |
| Champel, V | 1 |
| Radal, M | 1 |
| Moulin-Vallez, M | 1 |
| Jonville-Béra, AP | 1 |
| Autret-Leca, E | 1 |
| Canger, R | 1 |
| Canevini, MP | 1 |
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| Palmieri, C | 1 |
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| Granata, T | 1 |
| Hassibi, P | 1 |
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| Pardi, G | 1 |
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| Bass, WT | 1 |
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| Werner, AL | 1 |
| Reagan, TJ | 1 |
| Chaudron, LH | 1 |
| Jefferson, JW | 1 |
| Ebbesen, F | 1 |
| Joergensen, A | 1 |
| Hoseth, E | 1 |
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| Holsteen, V | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| A Study of Divalproex Sodium in Children With Autism Spectrum Disorder and Epileptiform EEG[NCT01170325] | Phase 2 | 0 participants (Actual) | Interventional | 2010-06-30 | Withdrawn | ||
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| Prophylactic Use of Immediate Postpartum Sertraline to Prevent Postpartum Depression: A Double Blind Randomized Placebo Controlled Trial[NCT02235064] | 2 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Low recruitment, completion of funding cycle) | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Antidepressant Side-Effect Checklist (ASEC) was employed to detect any adverse reaction to treatment regimens (NCT02235064)
Timeframe: Discharge from hospital to 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 1 |
"Patients met with single psychiatrist (co-investigator), blinded to group assignment, who evaluated the patient using Edinburgh Postpartum Depression Screen, Hamilton Depression Rating Scale, Global Assessment of Functioning Scale, and clinical assessment~0 = No postpartum depression up to 12 weeks following discharge from hospital~1 = Postpartum depression up to 12 weeks following discharge from hospital" (NCT02235064)
Timeframe: Discharge from hospital to 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Participants (Count of Participants) |
|---|---|
| Sertraline | 0 |
| Placebo | 0 |
(NCT02235064)
Timeframe: 12 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 5301 |
| Placebo | 4734 |
(NCT02235064)
Timeframe: 4 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 3033 |
| Placebo | 2750 |
(NCT02235064)
Timeframe: 8 weeks postpartum
| Intervention | Grams (Mean) |
|---|---|
| Sertraline | 5301 |
| Placebo | 3685 |
29 reviews available for carbamazepine and Complications, Pregnancy
| Article | Year |
|---|---|
Psychotropic drug use in perinatal women with bipolar disorder.
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Drug Elimination Routes; Fe | 2020 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 2017 |
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Autistic Disorder; Bayes Theorem; Breast Feeding; Carbamazepine; Child; Epilepsy; F | 2017 |
Adverse outcomes during pregnancy and major congenital malformations in infants of patients with bipolar and schizoaffective disorders treated with antiepileptic drugs: A systematic review.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Female; Humans | 2019 |
Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring.
Topics: Antidepressive Agents; Carbamazepine; Drug Monitoring; Female; Humans; Lamotrigine; Mood Disorders; | 2014 |
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu | 2014 |
Is carbamazepine a human teratogen?
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Carbamazepine; Epilepsy; Female; Fet | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Epileptic disorders in pregnancy: an overview.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag | 2008 |
Mood stabilizers in pregnancy: a systematic review.
Topics: Abnormalities, Drug-Induced; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Carbamazepin | 2010 |
Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Europe; | 2010 |
Is there an association between maternal carbamazepine use during pregnancy and eye malformations in the child?
Topics: Carbamazepine; Databases as Topic; Epilepsy; Eye Abnormalities; Female; Humans; Incidence; Netherlan | 2002 |
Pathobiology and genetics of neural tube defects.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Genetic Predisposition to Dis | 2003 |
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Safety of the newer antiepileptic drug oxcarbazepine during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Female; Humans; Oxcarba | 2005 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
ACOG Practice Bulletin: Clinical management guidelines for obstetrician-gynecologists number 92, April 2008 (replaces practice bulletin number 87, November 2007). Use of psychiatric medications during pregnancy and lactation.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Bipolar Disorder; Breast Feed | 2008 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo | 1981 |
Mood stabilizers during breastfeeding: a review.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Cyclohexanecarbo | 2000 |
Oxcarbazepine, an antiepileptic agent.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; | 2001 |
The effects of lithium, valproic acid, and carbamazepine during pregnancy and lactation.
Topics: Adult; Anticonvulsants; Antimanic Agents; Carbamazepine; Female; Humans; Lactation; Lithium; Pregnan | 2001 |
Spina bifida in infants of women treated with carbamazepine during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Human | 1991 |
Restless legs syndrome in pregnancy. Case reports.
Topics: Carbamazepine; Female; Humans; Pregnancy; Pregnancy Complications; Restless Legs Syndrome | 1990 |
Epilepsy in women of childbearing age.
Topics: Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications | 1989 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Problems and management of the pregnant woman with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pr | 1987 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
5 trials available for carbamazepine and Complications, Pregnancy
| Article | Year |
|---|---|
AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies.
Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Monitoring; Epilepsy; Female; Humans; Lamo | 2018 |
Major malformations in offspring of women with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Logistic Mode | 2003 |
Evaluation of antiepileptic drugs in pregnancy in a Jordanian army hospital.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Clinical Protocols; Drug Monitor | 2005 |
In utero antiepileptic drug exposure: fetal death and malformations.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Cognition; Female; Fetal Death; | 2006 |
Effects of pregnancy on various pathways of human antiepileptic drug metabolism.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1997 |
144 other studies available for carbamazepine and Complications, Pregnancy
| Article | Year |
|---|---|
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies; | 2022 |
Specific fetal malformations following intrauterine exposure to antiseizure medication.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Carbamazepine; Female; Humans; Male; Pregna | 2023 |
Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lamotrigine; Preg | 2023 |
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam | 2020 |
[New recommendations for antiepileptic drug therapy: the last piece in the review of epilepsy care].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Pre | 2020 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
Antiepileptic drugs and depression during pregnancy in women with epilepsy.
Topics: Adult; Anticonvulsants; Australia; Carbamazepine; Depression; Epilepsy; Female; Humans; Levetiraceta | 2020 |
Anti-epileptic drug exposure and risk of foetal death in utero.
Topics: Adult; Anticonvulsants; Australia; Carbamazepine; Epilepsy; Female; Fetal Death; Humans; Pregnancy; | 2018 |
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Fol | 2018 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anticonvulsants; Body Height; Body Weight; Carbamazepine; | 2018 |
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Hu | 2018 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Developmental outcomes at age four following maternal antiepileptic drug use.
Topics: Adult; Anticonvulsants; Carbamazepine; Child Development; Child, Preschool; Cohort Studies; Epilepsy | 2019 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Com | 2013 |
Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; India; Pregna | 2013 |
Carbamazepine clearance and seizure stability during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; | 2014 |
Association of certain chronic maternal diseases with the risk of specific congenital heart defects: a population-based study.
Topics: Adult; Anticonvulsants; Aortic Coarctation; Carbamazepine; Case-Control Studies; Chronic Disease; Di | 2014 |
IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Development; Epilepsy; Female; Humans; Intellige | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
Valproate and pregnancy: think again.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
[Valproic acid responsible for low IQ].
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationsh | 2016 |
Prenatal exposure to antiepileptic drugs and use of primary healthcare during childhood: a population-based cohort study in Denmark.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Denmark; Epilepsy; Femal | 2017 |
Seizure deterioration in women treated with oxcarbazepine during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Humans; Oxcarbazepine; Pregnancy; Pregnancy Complicat | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
[A case report of monitoring on carbamazepine in breast feeding woman].
Topics: Adult; Breast Feeding; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epileps | 2010 |
Carbamazepine in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 2010 |
Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Drug Thera | 2010 |
Carbamazepine in pregnancy: Levetiracetam and lamotrigine are better options.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Contraindications; Epilepsy; Female; Hu | 2011 |
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities; | 2011 |
Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Canada; Carbamazepine; Cohort Studies; Drug Therapy, C | 2011 |
Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States.
Topics: Anticonvulsants; Carbamazepine; Cleft Palate; Female; Humans; Pregnancy; Pregnancy Complications; Pr | 2011 |
Use of antiepileptic medications in pregnancy in relation to risks of birth defects.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hu | 2011 |
Perioperative management of a parturient with hyponatraemia due to carbamazepine therapy.
Topics: Adult; Anesthesia, Obstetrical; Anticonvulsants; Carbamazepine; Cesarean Section; Female; Humans; Hy | 2012 |
Is carbamazepine safe to take during pregnancy?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Neural Tube D | 2012 |
Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Epil | 2012 |
Severe consequences of carbamazepine exposure in utero.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant | 2011 |
Effects of prenatal exposure to carbamazepine on brainstem auditory evoked potentials in infants of epileptic mothers.
Topics: Adult; Anticonvulsants; Carbamazepine; Embryonic and Fetal Development; Epilepsy; Evoked Potentials, | 2002 |
Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Chondrodysplasia Punctata; Craniofacial Abnormalit | 2002 |
A pregnant woman with newly diagnosed epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Tolerance; Epilepsies, Partial; Epilepsy, Generalized; F | 2003 |
The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.
Topics: Abortion, Induced; Anticonvulsants; Australia; Carbamazepine; Cohort Studies; Congenital Abnormaliti | 2003 |
Anticonvulsant hypersensitivity reaction in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Female; Humans; Meningeal Neoplasms; Meningio | 2003 |
Major malformations in offspring of women with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Logistic Mode | 2003 |
Normal intelligence in children with prenatal exposure to carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu | 2004 |
Oxcarbazepine in pregnancy: clinical experience in Argentina.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Argentina; Carbamazepine; Drug Therapy, Combination; E | 2004 |
Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Child; Cohort Studies; Confoundi | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
Mega-dose carbamazepine complicating third trimester of pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Cardiotocography; Diagnosis, Differential; Female; Fetal Bloo | 2005 |
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child | 2006 |
Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Femal | 2006 |
Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Relations | 2006 |
Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland.
Topics: Adolescent; Adult; Anticonvulsants; Birth Rate; Carbamazepine; Cohort Studies; Epilepsy; Female; Fin | 2006 |
Treatment with oxcarbazepine during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy, Complex Partial; Female; Humans; Oxcarbazepine; Pre | 2006 |
Women on the verge.
Topics: Adult; Bipolar Disorder; Carbamazepine; Decision Making; Female; Humans; Pregnancy; Pregnancy Compli | 2006 |
The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Education, Special; Epilepsy; Female; Humans; Ment | 2006 |
Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy.
Topics: Analysis of Variance; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Res | 2006 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus | 2007 |
Transposition of the great arteries in a newborn whose mother was treated with carbamazepine during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Female; Humans; Infant, Newborn; Mal | 2007 |
Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood.
Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcifediol; C | 1984 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
[Treatment of pregnant epileptics with carbamazepine. Preliminary report].
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Co | 1984 |
Psychomotor status--a female case in the 34th week of pregnancy.
Topics: Adult; Carbamazepine; Clonazepam; Drugs, Chinese Herbal; Electroencephalography; Epilepsy; Epilepsy, | 1983 |
Carbamazepine, seizure disorders, and pregnancy.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complicat | 1983 |
Carbamazepine and carbamazepine-10,11- epoxide during pregnancy and postnatal period in epileptic mother and their nursed infants: pharmacokinetics and clinical effects.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; | 1983 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cleft Palate; Eyelid Diseases; | 1981 |
Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy.
Topics: Carbamazepine; Case-Control Studies; Child; Cognition; Developmental Disabilities; Female; Humans; I | 1994 |
Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenytoi | 1995 |
Diabetes insipidus.
Topics: Benzothiadiazines; Carbamazepine; Chlorpropamide; Clofibrate; Diabetes Insipidus; Diuretics; Female; | 1994 |
Lithium: the present and the future.
Topics: Acute Disease; Bipolar Disorder; Carbamazepine; Depressive Disorder; Drug Interactions; Female; Huma | 1995 |
Radial ray aplasia in utero: a prenatal finding associated with valproic acid exposure.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Carbamazepine; Epilepsy, Absence; Female; Huma | 1994 |
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther | 1993 |
[Diabetes insipidus during pregnancy: apropos of 2 case reports].
Topics: Adult; Carbamazepine; Deamino Arginine Vasopressin; Diabetes Insipidus; Female; Humans; Infant, Newb | 1994 |
Teratogenicity of antiepileptic drugs and drug specific malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug | 1993 |
Sporadic Pick's disease in a 28-year-old woman.
Topics: Adult; Atrophy; Carbamazepine; Dementia; Electroconvulsive Therapy; Female; Frontal Lobe; Haloperido | 1993 |
Practices of epilepsy during pregnancy: a survey of Canadian neurologists.
Topics: Anticonvulsants; Canada; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Neurolo | 1993 |
The 10,11-epoxide-10,11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, comedication, and relation to outcome of pregnancy.
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Carbamazepine; Cohort Studies; Dose-Response Relationsh | 1993 |
Paralytic ileus in a fetus-neonate after maternal intake of benzodiazepine.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Female; Fetal Diseases; Humans; Infant, | 1995 |
Fetal malformations in an epileptic pregnant woman treated with carbamazepine.
Topics: Abnormalities, Drug-Induced; Abortion, Eugenic; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Fem | 1996 |
[Epilepsy and pregnancy. Prospective study of 100 cases].
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Birth Weight; Carbamazepine; Epilepsy; Female; Hum | 1996 |
Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child Development; Child, Preschool; Cr | 1996 |
Pharmacokinetics of oxcarbazepine and carbamazepine in human placenta.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epilepsy; Fe | 1997 |
[Pharmacokinetic variations in anticonvulsants in Mexican epileptic women during different stages of the postpartum period].
Topics: Animals; Anticonvulsants; Carbamazepine; Cricetinae; Epilepsy; Female; Humans; Milk, Human; Phenytoi | 1997 |
[Carbamazepine and vigabatrin in epileptic pregnant woman and side effects in the newborn infant].
Topics: Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Chlorine; Drug Therapy, Combination; Epilepsy; | 1997 |
Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Breast Feeding; Carbamazepine; Female; Fluoxetine; Humans; | 1998 |
Teratogenic effects of antiepileptic drugs: what do we advise patients?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Patient Advoc | 1997 |
Outcome of pregnancies in epileptic women: a study in Saudi Arabia.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Middle Aged; Pregnancy; | 1999 |
[Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Humans; Neural Tube Defects; Pregnancy | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
Radial microbrain form of micrencephaly: possible association with carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Infant, Newborn; Male; Microcephaly; Pregnancy; Preg | 1999 |
Body dimensions of infants exposed to antiepileptic drugs in utero: observations spanning 25 years.
Topics: Anticonvulsants; Birth Weight; Body Height; Carbamazepine; Drug Therapy, Combination; Embryonic and | 2000 |
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I | 2000 |
Population based, prospective study of the care of women with epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Death; Guidelin | 2000 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Antenatal carbamazepine use associated with d-TGA and ASD.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Heart Septal Defects, Atrial; Humans; Infan | 2002 |
Transplacental passage of oxcarbazepine and its metabolites in vivo.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Blood; Humans; Maternal-Fetal Exchang | 2001 |
Neonatal cholestatic hepatitis from carbamazepine exposure during pregnancy and breast feeding.
Topics: Breast Feeding; Carbamazepine; Chemical and Drug Induced Liver Injury; Cholestasis; Epilepsy; Female | 2002 |
Carbamazepine in two pregnancies.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Fetal Death; Humans; Maternal-F | 1979 |
[Neonatal abstinence syndrome in children whose mothers were treated for epilepsy during pregnancy].
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1978 |
Carbamazepine levels in pregnancy and lactation.
Topics: Adult; Carbamazepine; Epilepsy, Temporal Lobe; Female; Fetal Blood; Fetus; Humans; Lactation; Milk, | 1979 |
[Antiepileptics, pregnancy and breast feeding].
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Breast Feeding; Carbamazepine; Epilepsy; Female; Hum | 1976 |
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines; | 1976 |
Disposition of placentally transferred carbamazepine (Tegretol) in the newborn.
Topics: Carbamazepine; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Maternal-Fetal Exchan | 1975 |
Salivary concentrations of antiepileptic drugs, oestradiol and progesterone throughout pregnancy in epileptic women.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Osmolar Concentration; P | 1992 |
Transient hepatic dysfunction in an infant of an epileptic mother treated with carbamazepine during pregnancy and breastfeeding.
Topics: Adult; Breast Feeding; Carbamazepine; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Infant, N | 1992 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Course of pregnancy and fetal outcome following maternal exposure to carbamazepine and phenytoin: a prospective study.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Carbamazepine; Epilepsy; Female; Humans; Phenytoi | 1992 |
Loss of seizure control associated with generic substitution of carbamazepine.
Topics: Adolescent; Adult; Carbamazepine; Drugs, Generic; Female; Humans; Male; Pregnancy; Pregnancy Complic | 1992 |
Teratogenesis with carbamazepine.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complicat | 1991 |
[The course of pregnancy and teratogenicity of antiepileptic agents in 66 patients with epilepsy].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combin | 1991 |
Spina bifida in infants of women taking carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Comp | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Dopa-responsive dystonia: long-term treatment response and prognosis.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Depression; Dihydroxyphenylalanine; Disab | 1991 |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Central Nervous System; Child; Child De | 1991 |
Teratogenic effect of carbamazepine.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Facial Bones; Female; Humans; Infant, N | 1991 |
On the use of anticonvulsants for manic depression during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bipolar Disorder; Carbamazepine; Female; Humans; Infan | 1990 |
Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding.
Topics: Breast Feeding; Carbamazepine; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Inf | 1990 |
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch | 1990 |
Epilepsy in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Child; Epilepsy; Female; Humans; Pregnancy; Pregn | 1989 |
Epilepsy in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Co | 1989 |
Pregnancy and epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estrogens; Female; Hum | 1989 |
Teratogenic effects of carbamazepine.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Fetus; Humans; Pregnancy; Pregnancy Co | 1989 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
Restless leg syndrome in pregnancy.
Topics: Carbamazepine; Female; Humans; Pregnancy; Pregnancy Complications; Restless Legs Syndrome | 1988 |
Congenital abnormalities in two sibs exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1988 |
Prescribing lithium for pregnant women.
Topics: Adult; Bipolar Disorder; Carbamazepine; Female; Gestational Age; Haloperidol; Humans; Infant, Newbor | 1988 |
Carbamazepine, clonazepam use during pregnancy.
Topics: Abnormalities, Drug-Induced; Benzodiazepinones; Carbamazepine; Clonazepam; Epilepsy; Female; Humans; | 1986 |
Carbamazepine in pregnancy.
Topics: Carbamazepine; Female; Humans; Pregnancy; Pregnancy Complications; Psychotic Disorders | 1986 |
The effects of long-term anticonvulsant drug therapy on vitamin D metabolites and mineral homeostasis in pregnant epileptic women and their newborns.
Topics: Adolescent; Adult; Anticonvulsants; Calcifediol; Calcitriol; Carbamazepine; Dihydroxycholecalciferol | 1985 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Persistent right umbilical vein--case report and review of literature.
Topics: Abnormalities, Multiple; Carbamazepine; Ectromelia; Epilepsy; Female; Heart Septal Defects, Atrial; | 1986 |
Seizure disorders and pregnancy.
Topics: Carbamazepine; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Seizures | 1986 |
Finger- and toenail hypoplasia after carbamazepine monotherapy in late pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Nails, | 1985 |
Letter: Digital hypoplasia and anticonvulsants during pregnancy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Female; Fingers; Maternal-Fetal Exchange; Ph | 1974 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |