carbamazepine and Coma
carbamazepine has been researched along with Coma in 38 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 15-year-old female subject presented comatose, in respiratory failure and shock, after the intentional ingestion of ∼280 extended-release 200-mg carbamazepine tablets with a peak serum concentration of 138 µg/mL (583." | 7.85 | Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. ( Agulnik, A; Bruccoleri, R; Burns, MM; Ebrahimi-Fakhari, D; Kelly, DP; Kohane, DS; Sahin, M; Yuskaitis, C, 2017) |
| "We report a rare case of severe hyponatremia with coma induced by the use of oxcarbazepine after one month of treatment, in pos-operatory of neurosurgery." | 7.72 | [Hyponatremic coma induced by oxcarbazepine: case report]. ( da Silva, JA; Holanda, MM; Quinino, SC, 2003) |
| "We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus." | 7.71 | [A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001) |
| "Carbamazepine (amizepine) is a widely used psychotropic agent." | 5.31 | Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide. ( Szymańska, B; Szymczak, WM; Topaciński, B; Winnicka, RI, 2002) |
| "However, hyponatremia is supposed to occur even more often than with CBZ." | 5.28 | Hyponatremic coma under oxcarbazepine therapy. ( Paulus, W; Steinhoff, BJ; Stodieck, SR; Stoll, KD, 1992) |
| "A 15-year-old female subject presented comatose, in respiratory failure and shock, after the intentional ingestion of ∼280 extended-release 200-mg carbamazepine tablets with a peak serum concentration of 138 µg/mL (583." | 3.85 | Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. ( Agulnik, A; Bruccoleri, R; Burns, MM; Ebrahimi-Fakhari, D; Kelly, DP; Kohane, DS; Sahin, M; Yuskaitis, C, 2017) |
| "We report a rare case of severe hyponatremia with coma induced by the use of oxcarbazepine after one month of treatment, in pos-operatory of neurosurgery." | 3.72 | [Hyponatremic coma induced by oxcarbazepine: case report]. ( da Silva, JA; Holanda, MM; Quinino, SC, 2003) |
| "We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus." | 3.71 | [A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001) |
| "The clinical effect of carbamazepine (CBZ) on neuromuscular transmission is described in two children who presented in coma with diffuse hypotonia and areflexia following CBZ overdose." | 3.70 | Neuromuscular transmission defect caused by carbamazepine. ( Berenson, F; Kaminski, HJ; Katirji, B; Zaidat, OO, 1999) |
| "Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death." | 3.70 | High-efficiency dialysis for carbamazepine overdose. ( Brophy, PD; Bunchman, TE; Kudelka, T; Maxvold, NJ; Schuerer, DJ, 2000) |
| " Flumazenil was efficient for leading out from coma in 86% of cases with poisoning only by benzodiazepines and 13% of cases with mixed intoxications mainly containing benzodiazepines and alcohol or carbamazepine." | 3.69 | [Suicidal poisoning with benzodiazepines]. ( Chodorowski, Z; Sein Anand, J, 1997) |
| "In a case of acute intoxication produced by carbamazepine overdose ataxia and cyclic coma were the salient features." | 3.67 | Carbamazepine poisoning: a case report. ( Manni, R; Maurelli, M; Sandrini, G; Savoldi, F; Tartara, A, 1986) |
| " Concurrently, we have noted a significant constant reduction of the half-life of CBZ from serum in the first group: 12." | 2.72 | Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. ( Amamou, M; Brahmi, N; Kouraichi, N; Thabet, H, 2006) |
| "Carbamazepine is known to produce the side effect of euphoria." | 1.48 | A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. ( Chen, YL; Li, JJ; Liu, CF; Wang, LJ; Xu, W; Zhao, Y, 2018) |
| "The incidences of convulsion, coma, and respiratory failure were 14 (35%), 10 (25%), and 3 (7." | 1.43 | Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series. ( Acikgoz, M; Alacam, A; Alacam, F; Guzel, A; Paksu, MS, 2016) |
| "Carbamazepine is an iminostilbene derivative structurally related to cyclic antidepressants which implies its potential cardiotxic properties, especially in acute poisoning." | 1.38 | Relationship of cardiovascular complications with level of consciousness in patients with acute carbamazepine intoxication. ( Gheshlaghi, F; Ghoreishi, A; Soh, EH; Yaraghi, A, 2012) |
| "Carbamazepine (CBZ) is a commonly used antiepileptic agent." | 1.36 | Management of a severe carbamazepine overdose with continuous venovenous hemodiafiltration. ( Goktas, U; Kati, I; Yuce, HH, 2010) |
| "In anticipation of coma, she is electively intubated to safely enable gastrointestinal decontamination with nasogastric activated charcoal." | 1.33 | Toxicology case of the month: Carbamazepine overdose. ( Daly, FF; Little, M; Murray, L; Soderstrom, J, 2006) |
| "Carbamazepine (amizepine) is a widely used psychotropic agent." | 1.31 | Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide. ( Szymańska, B; Szymczak, WM; Topaciński, B; Winnicka, RI, 2002) |
| "hypoglycaemia." | 1.31 | Management of unexplained coma in children. ( Graham, CA, 2000) |
| "Unfortunately, the patient died from adult respiratory distress syndrome." | 1.31 | Continuous EEG monitoring in a patient with massive carbamazepine overdose. ( De Rubeis, DA; Young, GB, 2001) |
| "Carbamazepine (CBZ) has been successfully employed in a variety of neurological and psychiatric disorders." | 1.29 | Signs and symptoms of carbamazepine overdose. ( Schmidt, S; Schmitz-Buhl, M, 1995) |
| "However, hyponatremia is supposed to occur even more often than with CBZ." | 1.28 | Hyponatremic coma under oxcarbazepine therapy. ( Paulus, W; Steinhoff, BJ; Stodieck, SR; Stoll, KD, 1992) |
| " In this series chronic exposure to carbamazepine did not appear to increase the risk of coma or respiratory depression for a given toxic serum level and may add some protective effect." | 1.28 | Carbamazepine overdose: a prospective study of serum levels and toxicity. ( Cookson, E; Krenzelok, EP; Spiller, HA, 1990) |
| "Because of deep coma and cardiovascular symptoms, intensive care and hemoperfusion were employed." | 1.27 | Charcoal hemoperfusion for treatment of serious carbamazepine poisoning. ( Idvall, J; Nilsson, C; Sterner, G, 1984) |
| "Treatment of carbamazepine overdose consists of aggressive orogastric lavage followed by activated charcoal administration with catharsis." | 1.27 | Acute carbamazepine intoxication: clinical spectrum and management. ( May, DC, 1984) |
| "The clinical spectrum consisted of coma, respiratory depression, seizures, myoclonus, nystagmus, hyperreflexia, hyporeflexia, delayed gastric emptying with cyclic coma, ataxia, sinus tachycardia, and atrioventricular conduction delay." | 1.26 | Acute carbamazepine toxicity resulting from overdose. ( Peterson, RG; Rumack, BH; Sullivan, JB, 1981) |
Research
Studies (38)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.95) | 18.7374 |
| 1990's | 10 (26.32) | 18.2507 |
| 2000's | 11 (28.95) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Agulnik, A | 1 |
| Kelly, DP | 1 |
| Bruccoleri, R | 1 |
| Yuskaitis, C | 1 |
| Ebrahimi-Fakhari, D | 1 |
| Sahin, M | 1 |
| Burns, MM | 1 |
| Kohane, DS | 1 |
| Xu, W | 1 |
| Chen, YL | 1 |
| Zhao, Y | 1 |
| Wang, LJ | 1 |
| Li, JJ | 1 |
| Liu, CF | 1 |
| Acikgoz, M | 1 |
| Paksu, MS | 1 |
| Guzel, A | 1 |
| Alacam, A | 1 |
| Alacam, F | 1 |
| Goktas, U | 1 |
| Kati, I | 1 |
| Yuce, HH | 1 |
| Quispe Gonzales, JO | 1 |
| Gómez Giralda, B | 1 |
| Ruiz-Zorrilla López, C | 1 |
| Acosta Ochoa, MI | 1 |
| Ampuero Anachuri, K | 1 |
| Molina Miguel, A | 1 |
| Gheshlaghi, F | 1 |
| Yaraghi, A | 1 |
| Soh, EH | 1 |
| Ghoreishi, A | 1 |
| Winnicka, RI | 1 |
| Topaciński, B | 1 |
| Szymczak, WM | 1 |
| Szymańska, B | 1 |
| Holanda, MM | 1 |
| Quinino, SC | 1 |
| da Silva, JA | 1 |
| Brahmi, N | 3 |
| Kouraichi, N | 2 |
| Thabet, H | 3 |
| Amamou, M | 3 |
| Paliwal, V | 1 |
| Garg, RK | 1 |
| Kar, AM | 1 |
| Singh, MK | 1 |
| Soderstrom, J | 1 |
| Murray, L | 1 |
| Little, M | 1 |
| Daly, FF | 1 |
| Abderrazek, H | 1 |
| Nilsson, C | 1 |
| Sterner, G | 1 |
| Idvall, J | 1 |
| May, DC | 1 |
| Hruby, K | 1 |
| Lenz, K | 1 |
| Druml, W | 1 |
| Kleinberger, G | 1 |
| Sullivan, JB | 1 |
| Rumack, BH | 1 |
| Peterson, RG | 1 |
| Carod Artal, FJ | 1 |
| Capablo Liesa, JL | 1 |
| Usón Martín, M | 1 |
| Marzo Sola, E | 1 |
| Schmidt, S | 1 |
| Schmitz-Buhl, M | 1 |
| Sälke-Kellermann, A | 1 |
| Baier, H | 1 |
| Rambeck, B | 1 |
| Boenigk, HE | 1 |
| Wolf, P | 1 |
| Baischer, W | 1 |
| Wagner, A | 1 |
| Seidler, D | 1 |
| Musalek, M | 1 |
| Laggner, A | 1 |
| Feldman, R | 1 |
| Burda, PR | 1 |
| Glińska-Serwin, M | 1 |
| Kotlarska, M | 1 |
| Szajewski, J | 1 |
| Chodorowski, Z | 1 |
| Sein Anand, J | 1 |
| Zagdoudi, I | 1 |
| Hédhili, A | 1 |
| Ben Salah, N | 1 |
| Yacoub, M | 1 |
| Zaidat, OO | 1 |
| Kaminski, HJ | 1 |
| Berenson, F | 1 |
| Katirji, B | 1 |
| Cordova, S | 1 |
| Lee, R | 1 |
| Schuerer, DJ | 1 |
| Brophy, PD | 1 |
| Maxvold, NJ | 1 |
| Kudelka, T | 1 |
| Bunchman, TE | 1 |
| Graham, CA | 1 |
| De Rubeis, DA | 1 |
| Young, GB | 1 |
| Ono, A | 1 |
| Yano, T | 1 |
| Sawaishi, Y | 1 |
| Komatsu, K | 1 |
| Takada, G | 1 |
| Steinhoff, BJ | 1 |
| Stoll, KD | 1 |
| Stodieck, SR | 1 |
| Paulus, W | 1 |
| Spiller, HA | 1 |
| Krenzelok, EP | 1 |
| Cookson, E | 1 |
| Wetzel, H | 1 |
| Heuser, I | 1 |
| Benkert, O | 1 |
| Weaver, DF | 1 |
| Camfield, P | 1 |
| Fraser, A | 1 |
| Tartara, A | 1 |
| Manni, R | 1 |
| Maurelli, M | 1 |
| Sandrini, G | 1 |
| Savoldi, F | 1 |
| Lehtovaara, R | 1 |
| Riddell, D | 1 |
| Leonard, BE | 1 |
| Sampson, D | 1 |
| Harasymiv, I | 1 |
| Hensley, WJ | 1 |
| Petersen, JL | 1 |
Trials
1 trial available for carbamazepine and Coma
| Article | Year |
|---|---|
Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning.
Topics: Adult; Anticonvulsants; Carbamazepine; Charcoal; Coma; Dose-Response Relationship, Drug; Female; Hal | 2006 |
Other Studies
37 other studies available for carbamazepine and Coma
| Article | Year |
|---|---|
Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose.
Topics: Adolescent; Barbiturates; Carbamazepine; Coma; Combined Modality Therapy; Decontamination; Drug Over | 2017 |
A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents.
Topics: Adolescent; Carbamazepine; Child; Coma; Drug Overdose; Female; Humans; Male; Renal Dialysis; Respira | 2018 |
Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series.
Topics: Adolescent; Brain Injuries; Carbamazepine; Child; Child, Preschool; Coma; Female; Glasgow Coma Scale | 2016 |
Management of a severe carbamazepine overdose with continuous venovenous hemodiafiltration.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Coma; Drug Overdose; Female; Hemodiafiltration; Humans; | 2010 |
[Severe ethanol poisoning treated by haemodialysis].
Topics: Acidosis; Acute Disease; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Coma; Em | 2011 |
Relationship of cardiovascular complications with level of consciousness in patients with acute carbamazepine intoxication.
Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Carbamazepine; Coma; Electrocardiography; Female; Glas | 2012 |
Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide.
Topics: Adult; Analgesics, Non-Narcotic; Biotransformation; Carbamazepine; Central Nervous System Depressant | 2002 |
[Hyponatremic coma induced by oxcarbazepine: case report].
Topics: Anticonvulsants; Carbamazepine; Coma; Epilepsy; Female; Humans; Hyponatremia; Middle Aged; Oxcarbaze | 2003 |
Oxcarbazepine induced hyponatremic coma.
Topics: Anticonvulsants; Carbamazepine; Child; Coma; Epilepsy, Tonic-Clonic; Humans; Hyponatremia; Male; Oxc | 2006 |
Toxicology case of the month: Carbamazepine overdose.
Topics: Adult; Anticonvulsants; Australia; Carbamazepine; Charcoal; Coma; Drug Overdose; Emergencies; Emerge | 2006 |
Clinical experience with carbamazepine overdose: relationship between serum concentration and neurological severity.
Topics: Adult; Carbamazepine; Coma; Drug Overdose; Female; Humans; Male; Nervous System Diseases; Retrospect | 2008 |
Charcoal hemoperfusion for treatment of serious carbamazepine poisoning.
Topics: Adult; Carbamazepine; Charcoal; Coma; Heart Block; Hemoperfusion; Humans; Male; Metabolic Clearance | 1984 |
Acute carbamazepine intoxication: clinical spectrum and management.
Topics: Acute Disease; Adult; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Catharsis; Charcoal; Coma; Gastri | 1984 |
[Experiences with acute carbamazepine poisoning].
Topics: Acute Disease; Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Coma; Dose-Response Relati | 1982 |
Acute carbamazepine toxicity resulting from overdose.
Topics: Adolescent; Adult; Carbamazepine; Coma; Female; Humans; Infant; Male | 1981 |
[Coma, opisthotonus and absence of vestibulo-ocular reflexes related to acute carbamazepine intoxication].
Topics: Adolescent; Brain; Brain Diseases; Carbamazepine; Coma; Glasgow Coma Scale; Humans; Reflex, Vestibul | 1995 |
Signs and symptoms of carbamazepine overdose.
Topics: Adolescent; Adult; Carbamazepine; Cerebellar Diseases; Coma; Drug Overdose; Epilepsy; Female; Humans | 1995 |
Acute encephalopathy with vigabatrin.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Com | 1993 |
[Carbamazepine poisoning: protracted course with development of intestinal atony and hepatic toxicity].
Topics: Adult; Bipolar Disorder; Carbamazepine; Chemical and Drug Induced Liver Injury; Coma; Drug Overdose; | 1994 |
[Correlation of carbamazepine levels in blood with clinical poisoning states, evaluated with the help of the APACHE II system and the Matthew coma scale].
Topics: Adult; APACHE; Carbamazepine; Coma; Female; Humans; Male; Severity of Illness Index | 1997 |
[Suicidal poisoning with benzodiazepines].
Topics: Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Carbamazepine; Coma; Ethanol; Female; Flumazen | 1997 |
[Acute self-induced poisoning with carbamazepine].
Topics: Acute Disease; Adult; Carbamazepine; Carbon; Coma; Female; Gastric Lavage; Humans; Hypotension; Male | 1999 |
Neuromuscular transmission defect caused by carbamazepine.
Topics: Adolescent; Analgesics, Non-Narcotic; Carbamazepine; Coma; Electric Stimulation; Humans; Male; Neura | 1999 |
Fixed, dilated pupils in the ICU: another recoverable cause.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Coma; Cyclohexanols | 2000 |
High-efficiency dialysis for carbamazepine overdose.
Topics: Anticonvulsants; Carbamazepine; Coma; Drug Overdose; Humans; Infant; Renal Dialysis; Seizures; Treat | 2000 |
Management of unexplained coma in children.
Topics: Anticonvulsants; Carbamazepine; Coma; Emergencies; Humans; Infant; Male | 2000 |
Continuous EEG monitoring in a patient with massive carbamazepine overdose.
Topics: Adult; Brain; Carbamazepine; Coma; Drug Overdose; Electroencephalography; Epilepsy, Tonic-Clonic; Fa | 2001 |
[A case of carbamazepine intoxication with alpha coma and status epilepticus].
Topics: Adolescent; Carbamazepine; Charcoal; Coma; Electroencephalography; Female; Gastric Lavage; Humans; M | 2001 |
Hyponatremic coma under oxcarbazepine therapy.
Topics: Anticonvulsants; Carbamazepine; Coma; Epilepsy; Female; Humans; Hyponatremia; Middle Aged; Oxcarbaze | 1992 |
Carbamazepine overdose: a prospective study of serum levels and toxicity.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Coma; Drug Overdose; Humans; | 1990 |
Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788.
Topics: Adult; Carbamazepine; Coma; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Femal | 1987 |
Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes.
Topics: Adolescent; Adult; Aggression; Ataxia; Carbamazepine; Chorea; Coma; Female; Hallucinations; Humans; | 1988 |
Carbamazepine poisoning: a case report.
Topics: Adolescent; Ataxia; Carbamazepine; Coma; Dysarthria; Female; Hematuria; Humans; Myoclonus; Respirati | 1986 |
[Therapy in traumatic epilepsy].
Topics: Adult; Barbiturates; Bromides; Carbamazepine; Coma; Disabled Persons; Drug Resistance; Epilepsy, Pos | 1971 |
Some properties of a coma producing material obtained from mammalian brain.
Topics: Amylases; Animals; Blood Pressure; Brain Chemistry; Carbamazepine; Cats; Cerebral Cortex; Chromatogr | 1970 |
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration; | 1971 |
[Carbamazepine (Tegretol) poisoning. A case report].
Topics: Adult; Carbamazepine; Coma; Dibenzazepines; Female; Humans; Respiratory Insufficiency; Suicide; Time | 1969 |