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carbamazepine and Coma

carbamazepine has been researched along with Coma in 38 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"A 15-year-old female subject presented comatose, in respiratory failure and shock, after the intentional ingestion of ∼280 extended-release 200-mg carbamazepine tablets with a peak serum concentration of 138 µg/mL (583."7.85Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. ( Agulnik, A; Bruccoleri, R; Burns, MM; Ebrahimi-Fakhari, D; Kelly, DP; Kohane, DS; Sahin, M; Yuskaitis, C, 2017)
"We report a rare case of severe hyponatremia with coma induced by the use of oxcarbazepine after one month of treatment, in pos-operatory of neurosurgery."7.72[Hyponatremic coma induced by oxcarbazepine: case report]. ( da Silva, JA; Holanda, MM; Quinino, SC, 2003)
"We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus."7.71[A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001)
"Carbamazepine (amizepine) is a widely used psychotropic agent."5.31Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide. ( Szymańska, B; Szymczak, WM; Topaciński, B; Winnicka, RI, 2002)
"However, hyponatremia is supposed to occur even more often than with CBZ."5.28Hyponatremic coma under oxcarbazepine therapy. ( Paulus, W; Steinhoff, BJ; Stodieck, SR; Stoll, KD, 1992)
"A 15-year-old female subject presented comatose, in respiratory failure and shock, after the intentional ingestion of ∼280 extended-release 200-mg carbamazepine tablets with a peak serum concentration of 138 µg/mL (583."3.85Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. ( Agulnik, A; Bruccoleri, R; Burns, MM; Ebrahimi-Fakhari, D; Kelly, DP; Kohane, DS; Sahin, M; Yuskaitis, C, 2017)
"We report a rare case of severe hyponatremia with coma induced by the use of oxcarbazepine after one month of treatment, in pos-operatory of neurosurgery."3.72[Hyponatremic coma induced by oxcarbazepine: case report]. ( da Silva, JA; Holanda, MM; Quinino, SC, 2003)
"We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus."3.71[A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001)
"The clinical effect of carbamazepine (CBZ) on neuromuscular transmission is described in two children who presented in coma with diffuse hypotonia and areflexia following CBZ overdose."3.70Neuromuscular transmission defect caused by carbamazepine. ( Berenson, F; Kaminski, HJ; Katirji, B; Zaidat, OO, 1999)
"Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death."3.70High-efficiency dialysis for carbamazepine overdose. ( Brophy, PD; Bunchman, TE; Kudelka, T; Maxvold, NJ; Schuerer, DJ, 2000)
" Flumazenil was efficient for leading out from coma in 86% of cases with poisoning only by benzodiazepines and 13% of cases with mixed intoxications mainly containing benzodiazepines and alcohol or carbamazepine."3.69[Suicidal poisoning with benzodiazepines]. ( Chodorowski, Z; Sein Anand, J, 1997)
"In a case of acute intoxication produced by carbamazepine overdose ataxia and cyclic coma were the salient features."3.67Carbamazepine poisoning: a case report. ( Manni, R; Maurelli, M; Sandrini, G; Savoldi, F; Tartara, A, 1986)
" Concurrently, we have noted a significant constant reduction of the half-life of CBZ from serum in the first group: 12."2.72Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. ( Amamou, M; Brahmi, N; Kouraichi, N; Thabet, H, 2006)
"Carbamazepine is known to produce the side effect of euphoria."1.48A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. ( Chen, YL; Li, JJ; Liu, CF; Wang, LJ; Xu, W; Zhao, Y, 2018)
"The incidences of convulsion, coma, and respiratory failure were 14 (35%), 10 (25%), and 3 (7."1.43Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series. ( Acikgoz, M; Alacam, A; Alacam, F; Guzel, A; Paksu, MS, 2016)
"Carbamazepine is an iminostilbene derivative structurally related to cyclic antidepressants which implies its potential cardiotxic properties, especially in acute poisoning."1.38Relationship of cardiovascular complications with level of consciousness in patients with acute carbamazepine intoxication. ( Gheshlaghi, F; Ghoreishi, A; Soh, EH; Yaraghi, A, 2012)
"Carbamazepine (CBZ) is a commonly used antiepileptic agent."1.36Management of a severe carbamazepine overdose with continuous venovenous hemodiafiltration. ( Goktas, U; Kati, I; Yuce, HH, 2010)
"In anticipation of coma, she is electively intubated to safely enable gastrointestinal decontamination with nasogastric activated charcoal."1.33Toxicology case of the month: Carbamazepine overdose. ( Daly, FF; Little, M; Murray, L; Soderstrom, J, 2006)
"Carbamazepine (amizepine) is a widely used psychotropic agent."1.31Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide. ( Szymańska, B; Szymczak, WM; Topaciński, B; Winnicka, RI, 2002)
"hypoglycaemia."1.31Management of unexplained coma in children. ( Graham, CA, 2000)
"Unfortunately, the patient died from adult respiratory distress syndrome."1.31Continuous EEG monitoring in a patient with massive carbamazepine overdose. ( De Rubeis, DA; Young, GB, 2001)
"Carbamazepine (CBZ) has been successfully employed in a variety of neurological and psychiatric disorders."1.29Signs and symptoms of carbamazepine overdose. ( Schmidt, S; Schmitz-Buhl, M, 1995)
"However, hyponatremia is supposed to occur even more often than with CBZ."1.28Hyponatremic coma under oxcarbazepine therapy. ( Paulus, W; Steinhoff, BJ; Stodieck, SR; Stoll, KD, 1992)
" In this series chronic exposure to carbamazepine did not appear to increase the risk of coma or respiratory depression for a given toxic serum level and may add some protective effect."1.28Carbamazepine overdose: a prospective study of serum levels and toxicity. ( Cookson, E; Krenzelok, EP; Spiller, HA, 1990)
"Because of deep coma and cardiovascular symptoms, intensive care and hemoperfusion were employed."1.27Charcoal hemoperfusion for treatment of serious carbamazepine poisoning. ( Idvall, J; Nilsson, C; Sterner, G, 1984)
"Treatment of carbamazepine overdose consists of aggressive orogastric lavage followed by activated charcoal administration with catharsis."1.27Acute carbamazepine intoxication: clinical spectrum and management. ( May, DC, 1984)
"The clinical spectrum consisted of coma, respiratory depression, seizures, myoclonus, nystagmus, hyperreflexia, hyporeflexia, delayed gastric emptying with cyclic coma, ataxia, sinus tachycardia, and atrioventricular conduction delay."1.26Acute carbamazepine toxicity resulting from overdose. ( Peterson, RG; Rumack, BH; Sullivan, JB, 1981)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199011 (28.95)18.7374
1990's10 (26.32)18.2507
2000's11 (28.95)29.6817
2010's6 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agulnik, A1
Kelly, DP1
Bruccoleri, R1
Yuskaitis, C1
Ebrahimi-Fakhari, D1
Sahin, M1
Burns, MM1
Kohane, DS1
Xu, W1
Chen, YL1
Zhao, Y1
Wang, LJ1
Li, JJ1
Liu, CF1
Acikgoz, M1
Paksu, MS1
Guzel, A1
Alacam, A1
Alacam, F1
Goktas, U1
Kati, I1
Yuce, HH1
Quispe Gonzales, JO1
Gómez Giralda, B1
Ruiz-Zorrilla López, C1
Acosta Ochoa, MI1
Ampuero Anachuri, K1
Molina Miguel, A1
Gheshlaghi, F1
Yaraghi, A1
Soh, EH1
Ghoreishi, A1
Winnicka, RI1
Topaciński, B1
Szymczak, WM1
Szymańska, B1
Holanda, MM1
Quinino, SC1
da Silva, JA1
Brahmi, N3
Kouraichi, N2
Thabet, H3
Amamou, M3
Paliwal, V1
Garg, RK1
Kar, AM1
Singh, MK1
Soderstrom, J1
Murray, L1
Little, M1
Daly, FF1
Abderrazek, H1
Nilsson, C1
Sterner, G1
Idvall, J1
May, DC1
Hruby, K1
Lenz, K1
Druml, W1
Kleinberger, G1
Sullivan, JB1
Rumack, BH1
Peterson, RG1
Carod Artal, FJ1
Capablo Liesa, JL1
Usón Martín, M1
Marzo Sola, E1
Schmidt, S1
Schmitz-Buhl, M1
Sälke-Kellermann, A1
Baier, H1
Rambeck, B1
Boenigk, HE1
Wolf, P1
Baischer, W1
Wagner, A1
Seidler, D1
Musalek, M1
Laggner, A1
Feldman, R1
Burda, PR1
Glińska-Serwin, M1
Kotlarska, M1
Szajewski, J1
Chodorowski, Z1
Sein Anand, J1
Zagdoudi, I1
Hédhili, A1
Ben Salah, N1
Yacoub, M1
Zaidat, OO1
Kaminski, HJ1
Berenson, F1
Katirji, B1
Cordova, S1
Lee, R1
Schuerer, DJ1
Brophy, PD1
Maxvold, NJ1
Kudelka, T1
Bunchman, TE1
Graham, CA1
De Rubeis, DA1
Young, GB1
Ono, A1
Yano, T1
Sawaishi, Y1
Komatsu, K1
Takada, G1
Steinhoff, BJ1
Stoll, KD1
Stodieck, SR1
Paulus, W1
Spiller, HA1
Krenzelok, EP1
Cookson, E1
Wetzel, H1
Heuser, I1
Benkert, O1
Weaver, DF1
Camfield, P1
Fraser, A1
Tartara, A1
Manni, R1
Maurelli, M1
Sandrini, G1
Savoldi, F1
Lehtovaara, R1
Riddell, D1
Leonard, BE1
Sampson, D1
Harasymiv, I1
Hensley, WJ1
Petersen, JL1

Trials

1 trial available for carbamazepine and Coma

ArticleYear
Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning.
    The American journal of emergency medicine, 2006, Volume: 24, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Charcoal; Coma; Dose-Response Relationship, Drug; Female; Hal

2006

Other Studies

37 other studies available for carbamazepine and Coma

ArticleYear
Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose.
    Pediatrics, 2017, Volume: 139, Issue:5

    Topics: Adolescent; Barbiturates; Carbamazepine; Coma; Combined Modality Therapy; Decontamination; Drug Over

2017
A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents.
    BioMed research international, 2018, Volume: 2018

    Topics: Adolescent; Carbamazepine; Child; Coma; Drug Overdose; Female; Humans; Male; Renal Dialysis; Respira

2018
Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Dec-02, Volume: 22

    Topics: Adolescent; Brain Injuries; Carbamazepine; Child; Child, Preschool; Coma; Female; Glasgow Coma Scale

2016
Management of a severe carbamazepine overdose with continuous venovenous hemodiafiltration.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Coma; Drug Overdose; Female; Hemodiafiltration; Humans;

2010
[Severe ethanol poisoning treated by haemodialysis].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:2

    Topics: Acidosis; Acute Disease; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Coma; Em

2011
Relationship of cardiovascular complications with level of consciousness in patients with acute carbamazepine intoxication.
    Medicinski arhiv, 2012, Volume: 66, Issue:1

    Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Carbamazepine; Coma; Electrocardiography; Female; Glas

2012
Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide.
    Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:6

    Topics: Adult; Analgesics, Non-Narcotic; Biotransformation; Carbamazepine; Central Nervous System Depressant

2002
[Hyponatremic coma induced by oxcarbazepine: case report].
    Arquivos de neuro-psiquiatria, 2003, Volume: 61, Issue:3B

    Topics: Anticonvulsants; Carbamazepine; Coma; Epilepsy; Female; Humans; Hyponatremia; Middle Aged; Oxcarbaze

2003
Oxcarbazepine induced hyponatremic coma.
    Neurology India, 2006, Volume: 54, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Child; Coma; Epilepsy, Tonic-Clonic; Humans; Hyponatremia; Male; Oxc

2006
Toxicology case of the month: Carbamazepine overdose.
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:11

    Topics: Adult; Anticonvulsants; Australia; Carbamazepine; Charcoal; Coma; Drug Overdose; Emergencies; Emerge

2006
Clinical experience with carbamazepine overdose: relationship between serum concentration and neurological severity.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:2

    Topics: Adult; Carbamazepine; Coma; Drug Overdose; Female; Humans; Male; Nervous System Diseases; Retrospect

2008
Charcoal hemoperfusion for treatment of serious carbamazepine poisoning.
    Acta medica Scandinavica, 1984, Volume: 216, Issue:1

    Topics: Adult; Carbamazepine; Charcoal; Coma; Heart Block; Hemoperfusion; Humans; Male; Metabolic Clearance

1984
Acute carbamazepine intoxication: clinical spectrum and management.
    Southern medical journal, 1984, Volume: 77, Issue:1

    Topics: Acute Disease; Adult; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Catharsis; Charcoal; Coma; Gastri

1984
[Experiences with acute carbamazepine poisoning].
    Der Nervenarzt, 1982, Volume: 53, Issue:7

    Topics: Acute Disease; Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Coma; Dose-Response Relati

1982
Acute carbamazepine toxicity resulting from overdose.
    Neurology, 1981, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Carbamazepine; Coma; Female; Humans; Infant; Male

1981
[Coma, opisthotonus and absence of vestibulo-ocular reflexes related to acute carbamazepine intoxication].
    Neurologia (Barcelona, Spain), 1995, Volume: 10, Issue:5

    Topics: Adolescent; Brain; Brain Diseases; Carbamazepine; Coma; Glasgow Coma Scale; Humans; Reflex, Vestibul

1995
Signs and symptoms of carbamazepine overdose.
    Journal of neurology, 1995, Volume: 242, Issue:3

    Topics: Adolescent; Adult; Carbamazepine; Cerebellar Diseases; Coma; Drug Overdose; Epilepsy; Female; Humans

1995
Acute encephalopathy with vigabatrin.
    Lancet (London, England), 1993, Jul-17, Volume: 342, Issue:8864

    Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Com

1993
[Carbamazepine poisoning: protracted course with development of intestinal atony and hepatic toxicity].
    Wiener klinische Wochenschrift, 1994, Volume: 106, Issue:1

    Topics: Adult; Bipolar Disorder; Carbamazepine; Chemical and Drug Induced Liver Injury; Coma; Drug Overdose;

1994
[Correlation of carbamazepine levels in blood with clinical poisoning states, evaluated with the help of the APACHE II system and the Matthew coma scale].
    Przeglad lekarski, 1997, Volume: 54, Issue:6

    Topics: Adult; APACHE; Carbamazepine; Coma; Female; Humans; Male; Severity of Illness Index

1997
[Suicidal poisoning with benzodiazepines].
    Przeglad lekarski, 1997, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Carbamazepine; Coma; Ethanol; Female; Flumazen

1997
[Acute self-induced poisoning with carbamazepine].
    Presse medicale (Paris, France : 1983), 1999, May-15, Volume: 28, Issue:18

    Topics: Acute Disease; Adult; Carbamazepine; Carbon; Coma; Female; Gastric Lavage; Humans; Hypotension; Male

1999
Neuromuscular transmission defect caused by carbamazepine.
    Muscle & nerve, 1999, Volume: 22, Issue:9

    Topics: Adolescent; Analgesics, Non-Narcotic; Carbamazepine; Coma; Electric Stimulation; Humans; Male; Neura

1999
Fixed, dilated pupils in the ICU: another recoverable cause.
    Anaesthesia and intensive care, 2000, Volume: 28, Issue:1

    Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Coma; Cyclohexanols

2000
High-efficiency dialysis for carbamazepine overdose.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Coma; Drug Overdose; Humans; Infant; Renal Dialysis; Seizures; Treat

2000
Management of unexplained coma in children.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2000, Volume: 7, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Coma; Emergencies; Humans; Infant; Male

2000
Continuous EEG monitoring in a patient with massive carbamazepine overdose.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2001, Volume: 18, Issue:2

    Topics: Adult; Brain; Carbamazepine; Coma; Drug Overdose; Electroencephalography; Epilepsy, Tonic-Clonic; Fa

2001
[A case of carbamazepine intoxication with alpha coma and status epilepticus].
    No to hattatsu = Brain and development, 2001, Volume: 33, Issue:6

    Topics: Adolescent; Carbamazepine; Charcoal; Coma; Electroencephalography; Female; Gastric Lavage; Humans; M

2001
Hyponatremic coma under oxcarbazepine therapy.
    Epilepsy research, 1992, Volume: 11, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Coma; Epilepsy; Female; Humans; Hyponatremia; Middle Aged; Oxcarbaze

1992
Carbamazepine overdose: a prospective study of serum levels and toxicity.
    Journal of toxicology. Clinical toxicology, 1990, Volume: 28, Issue:4

    Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Coma; Drug Overdose; Humans;

1990
Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788.
    The Journal of nervous and mental disease, 1987, Volume: 175, Issue:4

    Topics: Adult; Carbamazepine; Coma; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Femal

1987
Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes.
    Neurology, 1988, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Aggression; Ataxia; Carbamazepine; Chorea; Coma; Female; Hallucinations; Humans;

1988
Carbamazepine poisoning: a case report.
    Italian journal of neurological sciences, 1986, Volume: 7, Issue:1

    Topics: Adolescent; Ataxia; Carbamazepine; Coma; Dysarthria; Female; Hematuria; Humans; Myoclonus; Respirati

1986
[Therapy in traumatic epilepsy].
    Duodecim; laaketieteellinen aikakauskirja, 1971, Volume: 87, Issue:16

    Topics: Adult; Barbiturates; Bromides; Carbamazepine; Coma; Disabled Persons; Drug Resistance; Epilepsy, Pos

1971
Some properties of a coma producing material obtained from mammalian brain.
    Neuropharmacology, 1970, Volume: 9, Issue:3

    Topics: Amylases; Animals; Blood Pressure; Brain Chemistry; Carbamazepine; Cats; Cerebral Cortex; Chromatogr

1970
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
    Clinical chemistry, 1971, Volume: 17, Issue:5

    Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration;

1971
[Carbamazepine (Tegretol) poisoning. A case report].
    Ugeskrift for laeger, 1969, Jun-26, Volume: 131, Issue:26

    Topics: Adult; Carbamazepine; Coma; Dibenzazepines; Female; Humans; Respiratory Insufficiency; Suicide; Time

1969