carbamazepine has been researched along with Clerambault Syndrome in 52 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of carbamazepine-induced leukopenia with subsequent successful carbamazepine management is presented." | 7.67 | Successful treatment course with carbamazepine despite initial significant leukopenia: case report. ( Regan, WM, 1987) |
| " Under the treatment with carbamazepine panic attacks improved." | 3.69 | [Panic attacks with cycloleptic course--differential diagnostic considerations in differentiating panic disorder from epileptic anxiety attacks]. ( Assion, HJ; Heinemann, F, 1996) |
| "Carbamazepine is now used by many clinicians in the treatment of bipolar disorder (BD) refractory to standard treatments, including lithium and neuroleptics." | 3.67 | Long-term response to carbamazepine: a retrospective study. ( Cohen, BM; Frankenburg, FR; Lipinski, JF; Tohen, M, 1988) |
| "A case of carbamazepine-induced leukopenia with subsequent successful carbamazepine management is presented." | 3.67 | Successful treatment course with carbamazepine despite initial significant leukopenia: case report. ( Regan, WM, 1987) |
| "The carbamazepine studies were inconclusive." | 2.38 | Nonneuroleptic treatment of disruptive behavior in organic mental syndromes. ( Perry, PJ; Smith, DA, 1992) |
| "Two had organic catatonic disorder and the third organic depressive disorder." | 1.30 | The treatment of stupor associated with MRI evidence of cerebrovascular disease. ( Herzberg, J; Ranger, M; Spear, J, 1997) |
| "Treatment with carbamazepine, verapamil, and fluoxetine greatly improved the patient's symptoms." | 1.29 | Neurobehavioural dysfunction following mild traumatic brain injury in childhood: a case report with positive findings on positron emission tomography (PET). ( Bushnell, DL; Hines, ME; Manshadi, FF; Roberts, MA, 1995) |
| "Carbamazepine was added to her treatment regimen with good results." | 1.27 | Bipolar illness following traumatic brain injury: treatment with lithium and carbamazepine. ( Hemsath, RH; Stewart, JT, 1988) |
| "Carbamazepine was given to five patients with mixed frontal lobe disease and a variety of primary psychiatric disorders." | 1.27 | Carbamazepine in mixed frontal lobe and psychiatric disorders. ( McAllister, TW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (44.23) | 18.7374 |
| 1990's | 28 (53.85) | 18.2507 |
| 2000's | 1 (1.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kessler, H | 1 |
| Kraft, S | 1 |
| Stoudemire, A | 1 |
| Nelson, A | 1 |
| Houpt, JL | 1 |
| Folks, DG | 1 |
| King, LD | 1 |
| Dowdy, SB | 1 |
| Petrie, WM | 1 |
| Jack, RA | 1 |
| Koomen, JC | 1 |
| Swenson, BR | 1 |
| Edwards, P | 1 |
| Geschwind, N | 1 |
| Shader, RI | 1 |
| Bear, D | 1 |
| North, B | 1 |
| Levin, K | 1 |
| Chetham, D | 1 |
| Roberts, MA | 1 |
| Manshadi, FF | 1 |
| Bushnell, DL | 1 |
| Hines, ME | 1 |
| DasGupta, K | 1 |
| Jefferson, JW | 2 |
| Steckler, TL | 1 |
| Rivey, MP | 1 |
| Allington, DR | 1 |
| Stone, JD | 1 |
| Serfoss, ML | 1 |
| Prettyman, R | 1 |
| Schüler, P | 1 |
| Kalb, R | 1 |
| Tohen, M | 2 |
| Castillo, J | 1 |
| Pope, HG | 1 |
| Herbstein, J | 1 |
| Varney, NR | 1 |
| Garvey, MJ | 1 |
| Cook, BL | 1 |
| Campbell, DA | 1 |
| Roberts, RJ | 1 |
| Mas, F | 1 |
| Prichep, LS | 1 |
| Alper, K | 1 |
| Payne, SD | 1 |
| Huang, SC | 1 |
| Tsai, SJ | 1 |
| Heinemann, F | 1 |
| Assion, HJ | 1 |
| Dantendorfer, K | 1 |
| Amering, M | 1 |
| Prayer, D | 1 |
| Maierhofer, D | 1 |
| Schnider, P | 1 |
| Katschnig, H | 1 |
| Spear, J | 1 |
| Ranger, M | 1 |
| Herzberg, J | 1 |
| Hardy-Baylé, MC | 1 |
| Helmchen, H | 1 |
| Dalby, MA | 1 |
| Rodin, EA | 1 |
| Smith, DA | 1 |
| Perry, PJ | 1 |
| Hässler, F | 1 |
| Gierow, B | 1 |
| Terao, T | 1 |
| Lewin, J | 1 |
| Sumners, D | 1 |
| Goldstein, LH | 1 |
| Patel, V | 1 |
| Aspinall, P | 1 |
| Lishman, WA | 1 |
| Watts, D | 1 |
| Ryback, RS | 1 |
| Gardner, EA | 1 |
| McNamara, ME | 1 |
| Fogel, BS | 1 |
| Greenspan, D | 1 |
| Schneier, HA | 1 |
| Kahn, D | 1 |
| Renshaw, PF | 1 |
| Ford, HE | 1 |
| Brotman, AW | 1 |
| Ruser, I | 1 |
| Laminack, L | 1 |
| Kessler, AJ | 1 |
| Barklage, NE | 1 |
| Foster, HG | 1 |
| Hillbrand, M | 1 |
| Chi, CC | 1 |
| Stewart, JT | 1 |
| Hemsath, RH | 1 |
| Degen, R | 1 |
| Degen, HE | 1 |
| Kuhlmann, HP | 1 |
| Gross, RA | 1 |
| Herridge, P | 1 |
| Müller, N | 1 |
| Günther, W | 1 |
| Horn, B | 1 |
| Laakmann, G | 1 |
| Kugler, J | 1 |
| Frankenburg, FR | 1 |
| Cohen, BM | 1 |
| Lipinski, JF | 1 |
| Bouvy, PF | 1 |
| van de Wetering, BJ | 1 |
| Meerwaldt, JD | 1 |
| Bruijn, JB | 1 |
| Leong, GB | 1 |
| Silva, JA | 1 |
| Patterson, JF | 1 |
| Regan, WM | 1 |
| Anton, RF | 1 |
| Waid, LR | 1 |
| Fossey, M | 1 |
| AuBuchon, P | 1 |
| Stone, JL | 1 |
| McDaniel, KD | 1 |
| Hughes, JR | 1 |
| Hermann, BP | 1 |
| Hofmann, WE | 1 |
| Przuntek, H | 1 |
| Mattes, JA | 1 |
| McAllister, TW | 1 |
| Myrstener, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression: A 42-Day, Single-Site, Forced-Titration, Parallel Group, Randomized, Double-Blind, Placebo Controlled Trial[NCT00621751] | 70 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Study physician's impression of change since study onset. Clinicians Global Impressions of Change (CGI) is a sensitive, standardized tool to assess psychopharmacologic treatment response completed by the study physician. The Global Improvement (GI) CGI subscale documented the clinician's impression of change. The GI uses a 7-point scale to assess beneficial and negative effects. Low GI values (1 -3) indicate improvement; higher values (4-7) represent worsening. (NCT00621751)
Timeframe: 42 days
| Intervention | units on a scale (Mean) |
|---|---|
| Carbamazepine | 3.1 |
| Placebo | 2.9 |
Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: 42 days
| Intervention | units on a scale (Mean) |
|---|---|
| Carbamazepine | 3.3 |
| Placebo | 3.1 |
Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: Day-42
| Intervention | score on a scale (Mean) |
|---|---|
| Carbamazepine | 3.1 |
| Placebo | 3.1 |
Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, the primary outcome was a composite measure of observer-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., observer-rated NPI-I/A Rasch construct scores). Mean day-42 observer-rated NPI-I/A Rasch construct scores were compared between placebo vs. carbamazepine using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: 42 days
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Carbamazepine | 37.7 |
| Placebo | 36.7 |
Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, a composite measure of participant-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., participant-rated NPI-I/A Rasch construct scores). Mean day-42 participant-rated NPI-I/A Rasch construct scores were compared between placebo vs. CBZ using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: Day 42
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Carbamazepine | 37.5 |
| Placebo | 36.4 |
Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Observer. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: 42-day
| Intervention | Participants (Count of Participants) |
|---|---|
| Carbamazepine | 20 |
| Placebo | 26 |
Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Participant. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: Day-42
| Intervention | Participants (Count of Participants) |
|---|---|
| Carbamazepine | 21 |
| Placebo | 16 |
5 reviews available for carbamazepine and Clerambault Syndrome
| Article | Year |
|---|---|
[Neuropsychiatric symptoms in Sotos syndrome. Case report and review of the literature].
Topics: Adult; Antipsychotic Agents; Brain; Carbamazepine; Chromosome Deletion; Citalopram; Compulsive Behav | 2008 |
Interictal schizophrenia-like psychoses in temporal lobe epilepsy.
Topics: Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Functional L | 1983 |
Treatment of mania in the medically ill.
Topics: Bipolar Disorder; Carbamazepine; Comorbidity; Humans; Lithium; Metabolic Clearance Rate; Neurocognit | 1994 |
Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital.
Topics: Adult; Aged; Bipolar Disorder; Carbamazepine; Dose-Response Relationship, Drug; Drug Synergism; Drug | 1994 |
Nonneuroleptic treatment of disruptive behavior in organic mental syndromes.
Topics: Adrenergic beta-Antagonists; Antisocial Personality Disorder; Autistic Disorder; Carbamazepine; Deme | 1992 |
3 trials available for carbamazepine and Clerambault Syndrome
| Article | Year |
|---|---|
[Clinical and experimental control of optimal therapy in epilepsy].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Neurocognitive Disorder | 1990 |
Efficacy of carbamazepine in assaultive patients with frontal lobe dysfunction.
Topics: Adult; Affect; Aggression; Carbamazepine; Cognition Disorders; Electroencephalography; Frontal Lobe; | 1989 |
[Carbamazepine treatment of epileptic psychosis].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Depression; Dibenzazepi | 1968 |
44 other studies available for carbamazepine and Clerambault Syndrome
| Article | Year |
|---|---|
Carbamazepine treatment of selected affectively disordered inpatients.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Carbamazepine; Female; Humans; Lithium; Mal | 1982 |
Case 2: Behavioral changes with temporal lobe epilepsy: assessment and treatment.
Topics: Adult; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Female; Haloperidol; Humans; | 1980 |
Neurobehavioural dysfunction following mild traumatic brain injury in childhood: a case report with positive findings on positron emission tomography (PET).
Topics: Accidents, Traffic; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain Concussion; Bra | 1995 |
Alteration of carbamazepine pharmacokinetics in patients with traumatic brain injury.
Topics: Adult; Brain Damage, Chronic; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Ep | 1995 |
Lithium neurotoxicity at subtherapeutic serum levels.
Topics: Adult; Antipsychotic Agents; Ataxia; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, | 1994 |
[Anxiety attacks and epileptic seizures. Determining similarities based on a case report].
Topics: Adult; Arousal; Carbamazepine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; E | 1994 |
Concomitant use of valproate and carbamazepine in bipolar and schizoaffective disorders.
Topics: Adult; Bipolar Disorder; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1994 |
Identification of treatment-resistant depressives who respond favorably to carbamazepine.
Topics: Adult; Carbamazepine; Depressive Disorder; Dichotic Listening Tests; Epilepsies, Partial; Humans; Ma | 1993 |
Treatment resistant depression in a case of minor head injury: an electrophysiological hypothesis.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Carbamazepine; Cerebral Cortex; Depressive Disorder; | 1993 |
Carbamazepine and episodic dyscontrol.
Topics: Carbamazepine; Diagnosis, Differential; Epilepsy, Temporal Lobe; Humans; Neurocognitive Disorders; P | 1993 |
Hyponatremia and Stevens-Johnson syndrome in a patient receiving carbamazepine.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, | 1995 |
[Panic attacks with cycloleptic course--differential diagnostic considerations in differentiating panic disorder from epileptic anxiety attacks].
Topics: Anticonvulsants; Anxiety Disorders; Carbamazepine; Diagnosis, Differential; Epilepsy, Temporal Lobe; | 1996 |
Treatment of Koro and panic attacks after stroke.
Topics: Anticonvulsants; Carbamazepine; Cerebral Cortex; Cerebral Infarction; Clonazepam; Drug Therapy, Comb | 1996 |
The treatment of stupor associated with MRI evidence of cerebrovascular disease.
Topics: Aged; Anticonvulsants; Antidepressive Agents; Carbamazepine; Catatonia; Cerebrovascular Disorders; C | 1997 |
[Manic syndrome: diagnostic trends and principles of treatment].
Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Chl | 1998 |
[Psychiatric prognosis in epilepsies].
Topics: Affective Symptoms; Carbamazepine; Chronic Disease; Epilepsy; Humans; Intellectual Disability; Neuro | 1979 |
Behavioral effects of carbamazepine.
Topics: Adult; Behavior; Carbamazepine; Chemical Phenomena; Chemistry; Child; Epilepsy; Humans; Neurocogniti | 1975 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
[Rapid cycling syndromes in adolescence].
Topics: Adolescent; Affective Disorders, Psychotic; Carbamazepine; Contraceptives, Oral, Combined; Disorders | 1992 |
Episodic dyscontrol.
Topics: Carbamazepine; Humans; Mood Disorders; Neurocognitive Disorders | 1992 |
Successful treatment of episodic dyscontrol with carbamazepine.
Topics: Adolescent; Aggression; Brain Damage, Chronic; Carbamazepine; Dose-Response Relationship, Drug; Head | 1992 |
The effect of anticonvulsants on cognitive functioning following a probable encephalitic illness.
Topics: Carbamazepine; Drug Therapy, Combination; Electroencephalography; Encephalitis; Epilepsy, Temporal L | 1992 |
Neuroleptic malignant syndrome in a case of acute post-traumatic psychosis.
Topics: Antipsychotic Agents; Carbamazepine; Diagnosis, Differential; Haloperidol; Humans; Middle Aged; Neur | 1991 |
Limbic system dysrhythmia: a diagnostic electroencephalogram procedure utilizing procaine activation.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Diagnosis, D | 1991 |
Anticonvulsant-responsive panic attacks with temporal lobe EEG abnormalities.
Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Clonazepam; Electroencepha | 1990 |
Decisions in psychopharmacologic treatment.
Topics: Algorithms; Carbamazepine; Cerebrovascular Disorders; Clinical Protocols; Decision Making; Depressiv | 1990 |
Selective response to carbamazepine in a case of organic mood disorder.
Topics: Aged; Carbamazepine; Depressive Disorder; Female; Humans; Neurocognitive Disorders; Phenobarbital; P | 1990 |
Possible synergistic anticonvulsant effect of propranolol and carbamazepine.
Topics: Adult; Carbamazepine; Drug Synergism; Epilepsy, Temporal Lobe; Female; Humans; Neurocognitive Disord | 1990 |
Carbamazapine for behavioral disorders.
Topics: Carbamazepine; Electroencephalography; Epilepsy; Humans; Intellectual Disability; Neurocognitive Dis | 1990 |
Mood disorders in the psychoneurologic borderland: three cases of responsiveness to carbamazepine.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Depressive Disorder; Drug Therapy, Combinat | 1989 |
Bipolar illness following traumatic brain injury: treatment with lithium and carbamazepine.
Topics: Adult; Bipolar Disorder; Brain Injuries; Carbamazepine; Female; Humans; Lithium; Lithium Carbonate; | 1988 |
[Rolandi epilepsy--a frequent seizure disorder in childhood. Symptomatology, electroencephalography, etiology, therapy, prognosis].
Topics: Adolescent; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, Par | 1988 |
A maniclike illness associated with right frontal arteriovenous malformation.
Topics: Adolescent; Bipolar Disorder; Carbamazepine; Female; Frontal Lobe; Humans; Intracranial Arteriovenou | 1988 |
Psychopathological changes in a patient with rhythmic midtemporal discharges after antiepileptic medication.
Topics: Adult; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Humans; Ma | 1988 |
Long-term response to carbamazepine: a retrospective study.
Topics: Adult; Bipolar Disorder; Carbamazepine; Drug Administration Schedule; Drug Therapy, Combination; Fem | 1988 |
A case of organic brain syndrome following head injury successfully treated with carbamazepine.
Topics: Adult; Brain Concussion; Carbamazepine; Humans; Male; Neurocognitive Disorders; Temporal Lobe | 1988 |
Carbamazepine use in assaultive patients.
Topics: Aggression; Carbamazepine; Humans; Neurocognitive Disorders; Pilot Projects | 1988 |
Carbamazepine for assaultive patients with organic brain disease.
Topics: Adult; Aged; Carbamazepine; Dangerous Behavior; Humans; Male; Middle Aged; Neurocognitive Disorders; | 1987 |
Successful treatment course with carbamazepine despite initial significant leukopenia: case report.
Topics: Aged; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; | 1987 |
Case report of carbamazepine treatment of organic brain syndrome with psychotic features.
Topics: Carbamazepine; Humans; Male; Middle Aged; Neurocognitive Disorders; Neuropsychological Tests | 1986 |
Episodic dyscontrol disorder and paroxysmal EEG abnormalities: successful treatment with carbamazepine.
Topics: Adult; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Follow-Up Studies; Humans; Ma | 1986 |
[Partial seizure status with complex symptomatology. Case report on the problem of diagnostic difficulties].
Topics: Adult; Carbamazepine; Diagnosis, Differential; Diazepam; Drug Therapy, Combination; Electroencephalo | 1986 |
Metoprolol for intermittent explosive disorder.
Topics: Adult; Aggression; Anger; Carbamazepine; Humans; Male; Metoprolol; Neurocognitive Disorders; Propran | 1985 |
Carbamazepine in mixed frontal lobe and psychiatric disorders.
Topics: Aged; Brain Diseases; Carbamazepine; Frontal Lobe; Humans; Male; Mental Disorders; Middle Aged; Neur | 1985 |